CN113633622A - Herba lysimachiae capsule and preparation method thereof - Google Patents

Herba lysimachiae capsule and preparation method thereof Download PDF

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Publication number
CN113633622A
CN113633622A CN202110958340.5A CN202110958340A CN113633622A CN 113633622 A CN113633622 A CN 113633622A CN 202110958340 A CN202110958340 A CN 202110958340A CN 113633622 A CN113633622 A CN 113633622A
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capsule
herba lysimachiae
bag ring
christinae
powder
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CN113633622B (en
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丁京伟
列建乐
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Zhejiang Jingning Oujiang Capsule Co ltd
Zhejiang Wecome Pharmaceutical Co ltd
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Zhejiang Jingning Oujiang Capsule Co ltd
Zhejiang Wecome Pharmaceutical Co ltd
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
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    • A61J3/07Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/077Manufacturing capsule shells
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/4833Encapsulating processes; Filling of capsules
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
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    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract

The invention discloses a herba Lysimachiae Christinae capsule and a preparation method thereof, belonging to the field of capsules, wherein the herba Lysimachiae Christinae capsule comprises hollow capsules and powder in the herba Lysimachiae Christinae capsule, the powder in the herba Lysimachiae Christinae capsule is prepared by decocting herba Lysimachiae Christinae medicinal material with water for K times, then combining and filtering decoctions for K times, concentrating the filtrate into clear paste, drying under reduced pressure to obtain dry paste, and crushing the dry paste to obtain the herba Lysimachiae Christinae capsule; the hollow capsule comprises a capsule shell, a leakage-proof part and a feed inlet, wherein the capsule shell is provided with a pair of end parts, at least one telescopic part and a middle part; the lysimachia christinae hance capsule powder prepared by the scheme is brown powder, is slightly bitter and astringent in taste, clears away dampness and heat, treats stranguria and reduces swelling, is used for treating hot stranguria caused by sand, unsmooth urine and pain, jaundice and dark urine, carbuncle and furuncle, venomous snake bite, hepatobiliary calculus and lithangiuria, and is mainly orally taken.

Description

Herba lysimachiae capsule and preparation method thereof
Technical Field
The invention relates to the field of capsules, in particular to a lysimachia christinae hance capsule and a preparation method thereof.
Background
The encapsulated medicine is generally a powder or granules which is irritating to the esophagus and gastric mucosa, or a medicine which is bad in taste, easy to volatilize, easy to be decomposed by saliva in the oral cavity, and easy to be inhaled into the trachea. The medicines are filled into capsules, so that the medicine property of the medicines is protected from being damaged, and the digestive organs and the respiratory tract are protected. Removal of the capsule shell may result in loss of the drug, waste of the drug, and reduced efficacy. In addition, some drugs need to be dissolved and absorbed in the intestine, and the capsule protects the drug from gastric acid.
However, the existing capsule for containing the lysimachia christinae hance capsule powder is usually not convenient for a consumer to swallow because the capsule is poured into the 'body' part for containing, and then the 'cap' part is covered, so that the inside of the integrated capsule has a larger redundant space, the powder is in an unfilled state in the capsule, and the capsule has a larger volume due to more space waste; and the capsule volume cannot be adjusted according to the powder containing amount.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a lysimachia christinae hance capsule, wherein the lysimachia christinae hance capsule powder in the capsule is brown powder, is slightly bitter and astringent in taste, clears away heat and dampness, treats stranguria and reduces swelling, is used for treating heat stranguria, stranguria caused by sand, unsmooth urination and pain, jaundice and dark urine, carbuncle swelling and furuncle, venomous snake bite, hepatobiliary calculus and lithangiuria, and is mainly orally taken;
the second purpose is to provide a preparation method of the lysimachia christinae hance capsule.
In order to solve the above problems, the present invention adopts the following technical solutions.
A preparation method of herba Lysimachiae Christinae capsule comprises the following steps: the first step is as follows: preparing the desmodium capsule powder: weighing herba Lysimachiae Christinae medicinal materials with appropriate weight, decocting with water for K times, mixing the decoctions for K times, filtering, concentrating the filtrate to obtain fluid extract, drying under reduced pressure to obtain dry extract, pulverizing and mixing to obtain herba Lysimachiae Christinae dry extract powder, adding starch and magnesium stearate, and mixing to obtain herba Lysimachiae Christinae capsule powder; the second step is that: filling the desmodium capsule powder in the first step into the hollow capsule to obtain the desmodium capsule.
Further, the K is more than 1, M times of water is added into the lysimachia christinae hance for the first time, the lysimachia christinae hance is decocted for 1-3 hours, N times of water is added into the lysimachia christinae hance for each later time, the time of decoction is 1-3 hours, and the temperature is controlled to be 95-100 ℃.
Further, K is 3.
Further, the clear paste is obtained by combining double-effect concentration and scraper concentration, the relative density of the double-effect concentration of the clear paste is 1.15-1.25, the decompression temperature is 60-80 ℃, further, the temperature is 60 ℃, and the clear paste is stirred and circulated until the clear paste is uniform and all clear paste passes through a 100-mesh sieve during concentration; the relative density of the clear paste scraper plate concentration is 1.30-1.35, the decompression temperature is 60-80 ℃, and further, the temperature is 80 ℃.
Further, the second-effect concentration is performed until the mixture is uniform and passes through a 100-mesh sieve.
Further, the M is 12, the N is 10, and the decocting time is 1 hour.
A herba Lysimachiae Christinae capsule comprises hollow capsule and herba Lysimachiae Christinae powder in capsule, wherein the herba Lysimachiae Christinae powder in capsule is herba Lysimachiae Christinae capsule powder; the herba Lysimachiae capsule powder comprises magnesium stearate, starch and herba Lysimachiae dry extract powder.
Further, the longhairy antenoron herb dry paste powder is prepared by weighing longhairy antenoron herb with proper weight, adding water, decocting for K times, then combining the decoctions for K times, filtering, concentrating the filtrate into clear paste, drying under reduced pressure to obtain dry paste, and crushing and mixing to obtain the longhairy antenoron herb dry paste powder; the mass fraction of the magnesium stearate is 0.3-0.8%.
Further, the hollow capsule comprises a capsule shell, a leakage-proof part and a feed inlet; the capsule shell is provided with a pair of end parts, at least one telescopic part and a middle part, the end parts, the telescopic parts and the middle part are arranged along the direction far away from the central limit of the capsule shell by taking the center of the capsule shell as a limit; the feed port is arranged on the middle part and is communicated with the inside of the capsule shell and the outside; the leakage-proof part is connected to the outer wall of the capsule shell; the telescopic part is stretched, when the end parts positioned at the two sides of the capsule shell are deviated, the leakage-proof part is opened, and the feed inlet is exposed; the telescopic part is compressed, when the end parts at two sides of the capsule shell are close to each other, the leakage-proof part is closed, and the feed inlet is covered.
Further, the leakage-proof component comprises a first bag ring, a second bag ring and a locking fastener; the first bag ring is positioned at the inner side of the second bag ring; two telescopic parts are arranged on the capsule shell and are respectively arranged at two sides of the middle part; the first bag ring and the second bag ring are respectively connected to a pair of telescopic parts, a first connecting point and a second connecting point are formed on the telescopic parts, and the first connecting point and the second connecting point are both positioned on one side of the telescopic parts close to the end parts; when the telescopic part is compressed to the shortest, the first bag ring and the second bag ring are close to each other to cover the feed port, and the lock catch piece is used for clamping the first bag ring and the second bag ring; the telescopic part extends to lock the fastener for unlocking, and the first bag ring and the second bag ring are far away from each other to expose the feed port; the inner diameters of the first bag ring and the second bag ring are larger than the maximum outer diameter of the telescopic part after compression.
Furthermore, the locking fastener comprises a first convex part and a second convex part, the first convex part is integrally formed on the inner wall of the first bag ring, the second convex part is integrally formed on the inner wall of the second bag ring, and the distance between the first connecting point and the first convex part is greater than the distance between the second connecting point and the second convex part.
Further, the number of the first convex portions is set to be at least two.
Further, the inner diameter of the first bag ring is gradually increased along the direction close to the second bag ring.
Further, the leakage-proof part comprises a third bag ring and a secondary locking piece; one telescopic part is arranged on the capsule shell; the third bag ring is fixedly connected with the telescopic part, a third connecting point is formed between the third bag ring and the telescopic part, and the third connecting point is far away from the middle part; the secondary locking piece is arranged on one side, far away from the third connecting point, of the third bag ring and used for clamping the third bag ring and the capsule shell after the telescopic part is compressed.
Further, the length of the third bag ring is larger than the maximum length of the telescopic part after being stretched.
Further, the secondary locking member includes a third protrusion and a third recess; the third convex part and the inner side wall of the third bag ring are integrally formed and are far away from a third connecting point; the third concave part is formed by the connection part of the end part and the middle part; the third convex portion mates with the third concave portion.
Compared with the prior art, the invention has the advantages that:
the lysimachia christinae hance capsule powder prepared by the scheme is brown powder, slightly bitter and astringent in taste, capable of clearing away heat and dampness, treating stranguria and reducing swelling, and is used for treating heat stranguria, sand stranguria, unsmooth urination, jaundice and dark urine, carbuncle and furuncle, venomous snake bite, hepatobiliary calculus and lithangiuria.
Two, the hollow capsule of this scheme is through setting up the pars contractilis on the capsule body, and cooperation bag circle (first bag circle, second bag circle and third bag circle) sets up, and it makes things convenient for the feeding to expose the feed inlet after the pars contractilis elongates, utilizes the bag circle to shield the feed inlet again after the feeding finishes, has the protection once more of bag circle, prevents effectively that powder from spilling, especially has under two circumstances at the pars contractilis, and the protecting effect is better.
The hollow capsule of this scheme can also fill the biggest volume after the powder to the capsule body simultaneously and restrict after the location of capsule circle, and satisfies the volume that reduces the capsule body as far as after the powder weight for the capsule volume of producing is less, and the patient of being convenient for swallows, solves the current capsule volume too big and difficult problem of swallowing that causes.
The hollow capsule of this scheme can select the joint position through setting up more to first convex part or third concave part quantity to be convenient for adjust the inner space size according to the powder weight.
Fifthly, the hollow capsule telescopic parts can be arranged into one or two parts, and have various selectivity.
Sixthly, the hollow capsule inner space of this scheme compares and reduces greatly in current capsule, and the inside air holding capacity of capsule reduces, and the influence that the material caused the powder in the air reduces, and medicinal effect improves, and the shelf life also can be longer.
Drawings
FIG. 1 is a schematic cross-sectional view of an empty capsule of the present invention in a fully compressed state with two telescoping sections;
FIG. 2 is a schematic view of the structure at A in FIG. 1;
FIG. 3 is a schematic perspective view of the state of FIG. 1;
FIG. 4 is a schematic structural view of the empty capsule of the present invention in a semi-compressed state with two telescoping parts;
FIG. 5 is a perspective view of the state of FIG. 4;
FIG. 6 is a schematic view of the empty capsule of the present invention in a decompressed state with two bellows;
FIG. 7 is a perspective view of the FIG. 6 state;
FIG. 8 is a schematic perspective view of a hollow capsule of the present invention in a fully compressed state with a bellows;
FIG. 9 is a schematic view of the structure at B in FIG. 8;
FIG. 10 is a schematic perspective view showing the asymmetric end portions of the upper and lower sides of the state of FIG. 8;
fig. 11 is a schematic perspective view of the upper and lower end portions of the state of fig. 8 being symmetrical.
The reference numbers in the figures illustrate:
1 capsule shell, 1-1 end part, 1-2 telescopic part and 1-3 middle part;
2 leakage-proof parts, 21 a first bag ring, 211 a first convex part, 22 a second bag ring, 221 a second convex part, 23 a third bag ring, 231 a third convex part and 232 a third concave part; 2a first connection point, 2b second connection point, 2c third connection point;
3, feeding ports.
Detailed Description
The drawings in the embodiments of the invention will be combined; the technical scheme in the embodiment of the invention is clearly and completely described; obviously; the described embodiments are only some of the embodiments of the invention; but not all embodiments, are based on the embodiments of the invention; all other embodiments obtained by a person skilled in the art without making any inventive step; all fall within the scope of protection of the present invention.
Example 1:
1. pretreatment of traditional Chinese medicinal materials
Removing impurities, rush-washing with drinking water in a medicine washing pool, cutting into sections of less than or equal to 10cm, placing in a drying oven for drying, controlling the thickness to be 4-5 cm, controlling the drying temperature to be below 80 ℃ (controlling the temperature to be 70-80 ℃ optimally), and drying until the water content of the lysimachia christinae hance is less than or equal to 13.0%.
2. Post-treatment of Chinese medicinal materials
Decocting: decocting the processed herba Lysimachiae medicinal materials with water for three times, adding 12 times of water for decocting for 1 hour for the first time, adding 10 times of water for decocting for 1 hour for the second time and the third time respectively, keeping a slightly boiling state, controlling the temperature at 95-100 ℃, and filtering;
and (3) secondary concentration: carrying out secondary concentration on the filtrate to obtain clear paste with the relative density of 1.15-1.25 (60 ℃);
concentrating by a scraper: and pumping the double-effect concentrated solution into a scraper concentrator, and concentrating the double-effect concentrated solution into clear paste with the relative density of 1.30-1.35 (80 ℃). In the second-effect concentration, the mixture is beaten and circulated until the mixture is uniform and all the mixture passes through a 100-mesh sieve.
And (3) drying under reduced pressure: spreading the herba Lysimachiae fluid extract into stainless steel tray. The weight of each plate of the materials is about 3kg, the materials are put into an oven, and the door of the oven is tightly closed. Drying under reduced pressure at a temperature below 60 ℃ (30-60 ℃) until the water content is not over 8.0%;
crushing and mixing: pulverizing the dried herba Lysimachiae Christinae dry extract in a pulverizer, and sieving with 80 mesh sieve; then putting the crushed longhairy antenoron herb dry paste powder into a column type hopper mixer, wherein the mixing speed is 8r/min, the mixing time is 30min, and the mixed longhairy antenoron herb dry paste powder is contained in a container after the mixing time meets the requirement;
total mixing: loading the herba Lysimachiae Christinae dry extract powder, starch and magnesium stearate into a fixed hopper mixer, and mixing at a mixing speed (rotation speed of 10 r/min) for 15 min; and (4) obtaining the herba lysimachiae capsule powder after the total mixing time meets the requirement, filling the herba lysimachiae capsule powder into a material transfer barrel, and covering and sealing the barrel.
3. Filling in
Preparing hollow capsules, removing the outer package of the hollow capsules, taking the lysimachia christinae hance capsule powder, adjusting a filling machine polishing machine, wherein the filling amount of each capsule is 0.4 g/capsule (+ -9.0%), and the filling amount and other quality conditions must be checked every 15-20 minutes.
Example 2:
referring to fig. 1-7, the hollow capsule for holding the lysimachia christinae capsule powder comprises a capsule housing 1, a leakage-proof member 2 and a feed inlet 3; the capsule shell 1 is provided with a pair of end parts 1-1, two telescopic parts 1-2 and a middle part 1-3, the center of the capsule shell 1 is taken as a limit, and the end parts 1-1, the telescopic parts 1-2 and the middle part 1-3 are arranged along the direction far away from the center limit of the capsule shell 1; the feed port 3 is arranged on the middle part 1-3 and is communicated with the inside of the capsule shell 1 and the outside; the leakage-proof part 2 is connected with the outer wall of the capsule shell 1; the telescopic part 1-2 is stretched, when the end parts 1-1 at the two sides of the capsule shell 1 are deviated, the leakage-proof part 2 is opened, and the feed port 3 is exposed; the telescopic parts 1-2 are compressed, when the end parts 1-1 at the two sides of the capsule shell 1 are close to each other, the leakage-proof parts 2 are closed, and the feed inlet 3 is covered.
As shown in fig. 2 to 3, the leakage preventing member 2 includes a first bag ring 21, a second bag ring 22, and a locking member; and the first bag ring 21 is positioned inside the second bag ring 22; two telescopic parts 1-2 on the capsule shell 1 are arranged and are respectively arranged at two sides of the middle part 1-3; the first bag ring 21 and the second bag ring 22 are respectively connected to the pair of telescopic parts 1-2, a first connection point 2a and a second connection point 2b are formed on the telescopic parts 1-2, and the first connection point 2a and the second connection point 2b are both positioned on one side of the telescopic parts 1-2 close to the end part 1-1; when the telescopic part 1-2 is compressed to the shortest, the first bag ring 21 and the second bag ring 22 are close to each other to cover the feed port 3, and the first bag ring 21 and the second bag ring 22 are clamped by the locking fastener; the telescopic part 1-2 is extended to unlock the lock catch, and the first bag ring 21 and the second bag ring 22 are far away from the exposed feed port 3; the inner diameters of the first bag ring 21 and the second bag ring 22 are larger than the maximum outer diameter of the telescopic part 1-2 after compression.
As shown in fig. 2-3, the locking member includes a first protrusion 211 integrally formed on the inner wall of the first bag ring 21 and a second protrusion 221 integrally formed on the inner wall of the second bag ring 22, and the distance between the first connection point 2a and the first protrusion 211 is greater than the distance between the second connection point 2b and the second protrusion 221, so as to form a snap-fit connection.
During charging, the telescopic parts 1-2 are extended towards two outer sides, the first bag ring 21 and the second bag ring 22 are separated from each other, the feed port 3 is exposed for feeding, and after the feeding is finished, the bag is compressed in the opposite direction, fig. 1, 4 and 6 show that in one opening process of the feed port 3, the first bag ring 21 and the second bag ring 22 are close to each other, and the second bag ring 22 extends to the inner side of the first bag ring 21 until the first convex part 211 crosses the second convex part 221 to be clamped, it should be noted that the thickness sum of the first convex part 211 and the second convex part 221 is larger than the distance between the first bag ring 21 and the second bag ring 22, especially the inner diameter of the first bag ring 21 is gradually increased along the direction close to the second bag ring 22, so that the clamping is firmer due to the fact that the second convex part 221 is turned over the first convex part 211 along the inner wall of the first bag ring 21, the number of the first convex parts 211 can be set to be at least two, and the second convex parts 221 are turned over different first convex parts, the space inside the capsule housing 1 is changed to facilitate filling with different doses of powder, it being noted that the feed opening 3 must be covered otherwise a leaking situation may occur.
Example 3:
referring to fig. 8 to 11, unlike embodiment 2, one expansion and contraction part 1 to 2 is provided on the capsule housing 1.
As shown in fig. 8, the leakage preventing member 2 includes a third bag ring 23 and a secondary latch; the third bag ring 23 is fixedly connected with the telescopic part 1-2, a third connecting point 2c is formed between the third bag ring and the telescopic part 1-2, and the third connecting point 2c is far away from the middle part 1-3; the secondary locking piece is arranged on one side of the third bag ring 23 far away from the third connecting point 2c and used for clamping the third bag ring 23 and the capsule shell 1 after the telescopic part 1-2 is compressed; the length of the third bag ring 23 is larger than the maximum length of the expansion part 1-2 after expansion, so that the third bag ring 23 can conveniently close the feed opening 3 on the middle part 1-3.
As shown in fig. 9, the secondary locking member includes a third protrusion 231 and a third recess 232; the third convex portion 231 is integrally formed with the inner side wall of the third bag ring 23, and is away from the third connection point 2 c; the third recess 232 is formed by the junction of the end portion 1-1 and the middle portion 1-3; the third convex portion 231 matches the third concave portion 232.
When the materials are charged, the telescopic part 1-2 is stretched, the third bag ring 23 moves along with the telescopic part to expose the covered feed port 3, after the materials are charged into the feed port 3, the telescopic part 1-2 is compressed, the third bag ring 23 returns to close the feed port 3, and the third convex part 231 is clamped into the third concave part 232 to form a position which is not easy to be separated, a plurality of third concave parts 232 can be arranged on the end part 1-1 or the middle part 1-3, the internal space of the capsule shell 1 after clamping can be changed, so that the different quantities of the lysimachia christinae hance capsule powder can be conveniently filled, it needs to be noted that as long as the position of the third concave part 232 enables the bag ring 23 to cover the feed port 3, and the internal space of the capsule shell 1 is adjusted according to the quantities, the air containing quantity of the internal space can be greatly reduced, thereby reducing the influence of the substances in the air on the lysimachia christinae hance capsule powder, the medicinal effect is improved, and the shelf life is longer.
The above; but are merely preferred embodiments of the invention; the scope of the invention is not limited thereto; any person skilled in the art is within the technical scope of the present disclosure; the technical scheme and the improved concept of the invention are equally replaced or changed; are intended to be covered by the scope of the present invention.

Claims (10)

1. A preparation method of a herba Lysimachiae capsule is characterized in that: the method comprises the following steps:
the first step is as follows: preparing the desmodium capsule powder: weighing herba Lysimachiae Christinae medicinal materials with appropriate weight, decocting with water for K times, mixing the decoctions for K times, filtering, concentrating the filtrate to obtain fluid extract, drying under reduced pressure to obtain dry extract, pulverizing and mixing to obtain herba Lysimachiae Christinae dry extract powder, adding starch and magnesium stearate, and mixing to obtain herba Lysimachiae Christinae capsule powder;
the second step is that: filling the desmodium capsule powder in the first step into the hollow capsule to obtain the desmodium capsule.
2. The method for preparing herba Lysimachiae Christinae capsule as claimed in claim 1, wherein the capsule is prepared by the following steps: and K is more than 1, M times of water is added into the lysimachia christinae hance for the first time, the lysimachia christinae hance is decocted for 1-3 hours, N times of water is added into the lysimachia christinae hance for each later time, the time of decoction is 1-3 hours, and the temperature is controlled to be 95-100 ℃.
3. The method for preparing herba Lysimachiae Christinae capsule as claimed in claim 2, wherein: the K is 3, the M is 12, the N is 10, and the decocting time is 1 hour.
4. The method for preparing herba Lysimachiae Christinae capsule as claimed in claim 1, wherein the capsule is prepared by the following steps: the clear paste is obtained by combining double-effect concentration and scraper concentration, the relative density of the double-effect concentration of the clear paste is 1.15-1.25, the reduced pressure temperature is 60-80 ℃, and the clear paste is stirred and circulated until the clear paste is uniform in concentration and all clear paste passes through a 100-mesh sieve; the relative density of the clear paste scraper plate concentration is 1.30-1.35, and the decompression temperature is 60-80 ℃.
5. A herba Lysimachiae Christinae capsule is characterized in that: prepared by the preparation method of any one of claims 1 to 4, which comprises the powder in an empty capsule and a herba lysimachiae capsule; the herba Lysimachiae Christinae capsule powder comprises magnesium stearate, starch and herba Lysimachiae Christinae dry extract powder;
the herba Lysimachiae Christinae dry extract powder is prepared by weighing herba Lysimachiae Christinae medicinal materials with appropriate weight, decocting with water for K times, mixing the decoctions for K times, filtering, concentrating the filtrate to fluid extract, drying under reduced pressure to obtain dry extract, pulverizing and mixing to obtain herba Lysimachiae Christinae dry extract powder; the mass fraction of the magnesium stearate is 0.3-0.8%.
6. A herba lysimachiae capsule according to claim 1, wherein: the hollow capsule comprises a capsule shell (1), a leakage-proof part (2) and a feed inlet (3);
the capsule shell (1) is provided with a pair of end parts (1-1), at least one telescopic part (1-2) and a middle part (1-3), the center of the capsule shell (1) is taken as a limit, and the end parts (1-1), the telescopic parts (1-2) and the middle part (1-3) are arranged along the direction far away from the center limit of the capsule shell (1);
the feed port (3) is arranged on the middle part (1-3) and is communicated with the inside and the outside of the capsule shell (1);
the leakage-proof part (2) is connected to the outer wall of the capsule shell (1);
the telescopic part (1-2) is stretched, when the end parts (1-1) at the two sides of the capsule shell (1) are deviated, the leakage-proof part (2) is opened, and the feed port (3) is exposed; the telescopic parts (1-2) are compressed, when the end parts (1-1) positioned at the two sides of the capsule shell (1) are close to each other, the leakage-proof parts (2) are closed, and the feed inlet (3) is covered.
7. A herba Lysimachiae capsule according to claim 6, wherein: the leakage-proof part (2) comprises a first bag ring (21), a second bag ring (22) and a locking piece; the first bag ring (21) is positioned at the inner side of the second bag ring (22); two telescopic parts (1-2) on the capsule shell (1) are arranged and are respectively arranged at two sides of the middle part (1-3);
the first bag ring (21) and the second bag ring (22) are respectively connected to a pair of telescopic parts (1-2), a first connecting point (2 a) and a second connecting point (2 b) are formed on the telescopic parts (1-2), and the first connecting point (2 a) and the second connecting point (2 b) are both positioned on one side, close to the end part (1-1), of the telescopic parts (1-2);
when the telescopic part (1-2) is compressed to the shortest, the first bag ring (21) and the second bag ring (22) are close to each other to cover the feed port (3), and the first bag ring (21) and the second bag ring (22) are clamped by the locking fastener; the telescopic part (1-2) is extended to lock the lock piece for unlocking, and the first bag ring (21) and the second bag ring (22) are far away from each other to expose the feed port (3);
the inner diameters of the first bag ring (21) and the second bag ring (22) are larger than the maximum outer diameter of the telescopic part (1-2) after compression.
8. A herba Lysimachiae capsule according to claim 7, wherein: the fastener comprises a first convex part (211) integrally formed on the inner wall of the first bag ring (21) and a second convex part (221) integrally formed on the inner wall of the second bag ring (22), and the distance between the first connecting point (2 a) and the first convex part (211) is larger than the distance between the second connecting point (2 b) and the second convex part (221).
9. A herba Lysimachiae capsule according to claim 6, wherein: the leakage-proof part (2) comprises a third bag ring (23) and a secondary locking piece;
one telescopic part (1-2) on the capsule shell (1) is arranged; the third bag ring (23) is fixedly connected with the telescopic part (1-2), a third connecting point (2 c) is formed between the third bag ring and the telescopic part (1-2), and the third connecting point (2 c) is far away from the middle part (1-3);
the secondary locking piece is arranged on one side, far away from the third connecting point (2 c), of the third bag ring (23) and used for clamping the third bag ring (23) and the capsule shell (1) after the telescopic part (1-2) is compressed.
10. A herba lysimachiae capsule according to claim 9, wherein: the secondary locking member includes a third convex portion (231) and a third concave portion (232);
the third convex part (231) and the inner side wall of the third bag ring (23) are integrally formed and are far away from a third connecting point (2 c);
the third recess (232) is formed by the connection of the end portion (1-1) and the middle portion (1-3); the third convex portion (231) is matched with the third concave portion (232).
CN202110958340.5A 2021-08-20 2021-08-20 Herba lysimachiae capsule and preparation method thereof Active CN113633622B (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1478515A (en) * 2003-06-06 2004-03-03 广西万通制药有限公司 Desmodium preparation for treating urinary calculus, infection and cholelithiasis cholecy stolithiasis and chole cystitis and its production method
CN209500315U (en) * 2018-05-23 2019-10-18 晟源康生物科技有限公司 Ganoderma lucidum mycelium capsule structure

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1478515A (en) * 2003-06-06 2004-03-03 广西万通制药有限公司 Desmodium preparation for treating urinary calculus, infection and cholelithiasis cholecy stolithiasis and chole cystitis and its production method
CN209500315U (en) * 2018-05-23 2019-10-18 晟源康生物科技有限公司 Ganoderma lucidum mycelium capsule structure

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