CN113619218A - Taxus chinensis filler containing paclitaxel inner core and preparation and application of cloth - Google Patents
Taxus chinensis filler containing paclitaxel inner core and preparation and application of cloth Download PDFInfo
- Publication number
- CN113619218A CN113619218A CN202110916658.7A CN202110916658A CN113619218A CN 113619218 A CN113619218 A CN 113619218A CN 202110916658 A CN202110916658 A CN 202110916658A CN 113619218 A CN113619218 A CN 113619218A
- Authority
- CN
- China
- Prior art keywords
- layer
- paclitaxel
- inner core
- core filler
- cloth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000004744 fabric Substances 0.000 title claims abstract description 66
- 229930012538 Paclitaxel Natural products 0.000 title claims abstract description 65
- 229960001592 paclitaxel Drugs 0.000 title claims abstract description 65
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title claims abstract description 65
- 239000000945 filler Substances 0.000 title claims abstract description 59
- 241001149649 Taxus wallichiana var. chinensis Species 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 238000011049 filling Methods 0.000 claims abstract description 32
- 238000000034 method Methods 0.000 claims abstract description 15
- 239000010410 layer Substances 0.000 claims description 108
- 239000002344 surface layer Substances 0.000 claims description 46
- 230000003014 reinforcing effect Effects 0.000 claims description 30
- 239000000284 extract Substances 0.000 claims description 29
- 239000000463 material Substances 0.000 claims description 25
- 238000001035 drying Methods 0.000 claims description 21
- 239000012790 adhesive layer Substances 0.000 claims description 17
- 238000010298 pulverizing process Methods 0.000 claims description 16
- 229920000742 Cotton Polymers 0.000 claims description 15
- 238000004140 cleaning Methods 0.000 claims description 14
- 238000004806 packaging method and process Methods 0.000 claims description 14
- 239000002131 composite material Substances 0.000 claims description 9
- 241000522652 Ormosia <angiosperm> Species 0.000 claims description 7
- 229920000297 Rayon Polymers 0.000 claims description 7
- 210000002615 epidermis Anatomy 0.000 claims description 7
- 239000003292 glue Substances 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- 238000012805 post-processing Methods 0.000 claims description 7
- 238000007789 sealing Methods 0.000 claims description 7
- 238000001694 spray drying Methods 0.000 claims description 7
- 230000001954 sterilising effect Effects 0.000 claims description 7
- 238000000194 supercritical-fluid extraction Methods 0.000 claims description 7
- 238000012360 testing method Methods 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 2
- 230000001093 anti-cancer Effects 0.000 abstract description 6
- 230000035699 permeability Effects 0.000 abstract description 6
- 230000002265 prevention Effects 0.000 abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 4
- 206010028980 Neoplasm Diseases 0.000 abstract description 3
- 201000011510 cancer Diseases 0.000 abstract description 3
- 238000009413 insulation Methods 0.000 abstract description 3
- 230000002035 prolonged effect Effects 0.000 abstract description 3
- 238000004321 preservation Methods 0.000 abstract description 2
- 229920002521 macromolecule Polymers 0.000 description 5
- 239000009526 Fructus Akebiae Substances 0.000 description 4
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 4
- 206010006187 Breast cancer Diseases 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 125000002456 taxol group Chemical group 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 241001116500 Taxus Species 0.000 description 1
- 241001530121 Trollius Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 210000001099 axilla Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229930002995 diterpene alkaloid Natural products 0.000 description 1
- -1 diterpene alkaloid compound Chemical class 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 208000014829 head and neck neoplasm Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B5/00—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
- B32B5/02—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by structural features of a fibrous or filamentary layer
- B32B5/08—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by structural features of a fibrous or filamentary layer the fibres or filaments of a layer being of different substances, e.g. conjugate fibres, mixture of different fibres
-
- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41B—SHIRTS; UNDERWEAR; BABY LINEN; HANDKERCHIEFS
- A41B17/00—Selection of special materials for underwear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B3/00—Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shape; Layered products comprising a layer having particular features of form
- B32B3/02—Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shape; Layered products comprising a layer having particular features of form characterised by features of form at particular places, e.g. in edge regions
- B32B3/08—Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shape; Layered products comprising a layer having particular features of form characterised by features of form at particular places, e.g. in edge regions characterised by added members at particular parts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B33/00—Layered products characterised by particular properties or particular surface features, e.g. particular surface coatings; Layered products designed for particular purposes not covered by another single class
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B5/00—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
- B32B5/02—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by structural features of a fibrous or filamentary layer
- B32B5/06—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by structural features of a fibrous or filamentary layer characterised by a fibrous or filamentary layer mechanically connected, e.g. by needling to another layer, e.g. of fibres, of paper
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
- B32B7/04—Interconnection of layers
- B32B7/12—Interconnection of layers using interposed adhesives or interposed materials with bonding properties
-
- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41B—SHIRTS; UNDERWEAR; BABY LINEN; HANDKERCHIEFS
- A41B2400/00—Functions or special features of shirts, underwear, baby linen or handkerchiefs not provided for in other groups of this subclass
- A41B2400/22—Breathability, i.e. being vapour permeable and waterproof
-
- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41B—SHIRTS; UNDERWEAR; BABY LINEN; HANDKERCHIEFS
- A41B2400/00—Functions or special features of shirts, underwear, baby linen or handkerchiefs not provided for in other groups of this subclass
- A41B2400/32—Therapeutic use
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2262/00—Composition or structural features of fibres which form a fibrous or filamentary layer or are present as additives
- B32B2262/04—Cellulosic plastic fibres, e.g. rayon
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2262/00—Composition or structural features of fibres which form a fibrous or filamentary layer or are present as additives
- B32B2262/06—Vegetal fibres
- B32B2262/062—Cellulose fibres, e.g. cotton
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/20—Properties of the layers or laminate having particular electrical or magnetic properties, e.g. piezoelectric
- B32B2307/206—Insulating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/30—Properties of the layers or laminate having particular thermal properties
- B32B2307/304—Insulating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/50—Properties of the layers or laminate having particular mechanical properties
- B32B2307/51—Elastic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/50—Properties of the layers or laminate having particular mechanical properties
- B32B2307/554—Wear resistance
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/724—Permeability to gases, adsorption
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Materials Engineering (AREA)
- Textile Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a taxus chinensis inner core filler containing paclitaxel and a preparation application of a cloth, and relates to the technical field of preparation and application of the cloth. This preparation of chinese yew contains taxol inner core filler and cloth is used, including basic unit and back up coat, it pastes the layer to fix being provided with between basic unit and the back up coat, the back up coat is kept away from to paste the fixed filling layer that is provided with in layer one side, the filling layer is kept away from fixed first surface course that is provided with in back up coat one side. The invention provides a taxus chinensis containing paclitaxel inner core filler and a preparation application of a fabric, the paclitaxel inner core filler fabric prepared by the method not only has the functions of prevention and cancer resistance, but also has better elasticity and better wear resistance, the service life of the fabric is greatly prolonged, and the fabric also has the advantages of water resistance, moisture permeability, air permeability, insulation, heat preservation and the like, and has the characteristics of degradability, more convenient use and better anticancer effect.
Description
Technical Field
The invention relates to the technical field of preparation and application of cloth, in particular to a taxus chinensis filler containing a paclitaxel inner core and preparation and application of the cloth.
Background
Taxus genus: the plants are evergreen trees or shrubs, and are female and male heteroplants and cross-pollinated. The globeflower is small, grows in the axilla of the leaf singly and opens in early spring. The staminate flower is head-shaped inflorescence with handle and scale at base, has 6-14 stamens and shield shape, and each stamen has 4-9 anthers; the female ball flower has a top-born ovule, the base part of which is supported by a disk-shaped ovule, and the lower part of which is provided with a plurality of bracts. The seeds are nut-shaped and spherical, are born in red fleshy pseudoseed coats and mature in the same year.
The fruits, branches and leaves of the taxus chinensis are rich in paclitaxel, protein, mineral substances such as calcium, phosphorus, iron and the like and various vitamins, and are natural antioxidant and anti-aging plants.
Paclitaxel, a natural anticancer drug with the molecular formula of C47H51NO14, has been widely used clinically for the treatment of breast cancer, ovarian cancer, and some head and neck and lung cancers. Paclitaxel is taken as diterpene alkaloid compound with anticancer activity, has novel and complex chemical structure, wide and remarkable biological activity, completely new and unique action mechanism and scarce natural resources, is greatly favored by phytologists, chemists, pharmacologists and molecular biologists, and becomes an anticancer star which draws attention in the next half of the 20 th century and research focus.
Although various fabrics on the market have various excellent characteristics such as softness, wear resistance, water resistance, air permeability and the like, the fabrics generally have no characteristics of prevention and cancer resistance, and based on the characteristics, the preparation and application of the taxus chinensis containing paclitaxel inner core filler and the fabrics are provided.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides a preparation application of a taxus chinensis filler containing a paclitaxel inner core and a cloth, and solves the problem that the existing cloth has no prevention and anticancer functions.
(II) technical scheme
In order to achieve the purpose, the invention is realized by the following technical scheme: paclitaxel inner core filler cloth, including basic unit and back up coat, the fixed layer of pasting that is provided with between basic unit and the back up coat, the back up coat is kept away from and is pasted the fixed filling layer that is provided with in layer one side, the filling layer is kept away from fixed being provided with first surface course in back up coat one side, first surface course is kept away from the fixed second surface course that is provided with in filling layer one side.
Preferably, the adhesive layer is uniformly coated on the upper surface and the lower surface of the base layer, the reinforcing layer and the first surface layer are respectively connected on the upper surface and the lower surface of the filling layer in a needling composite mode, and the first surface layer and the second surface layer are manufactured in a composite mode.
Preferably, the material of the sticking layer is PU micropore glue.
Preferably, the first surface layer is made of a high-molecular waterproof breathable material.
Preferably, the second facing is made of 70% cotton plus 30% modal and viscose.
Preferably, the base layer is made of 100% pure cotton.
The preparation method of the paclitaxel inner core filler cloth is characterized by comprising the following steps: the method comprises the following steps:
s1, cleaning and crushing
Cleaning Taxus chinensis, pulverizing branches, stems, leaves, epidermis and roots of Taxus chinensis, and pulverizing to average particle diameter of less than 30 μm;
s2, standing and drying
Testing by a drying method, and drying until the moisture content is less than 5%;
s3, purifying
Performing supercritical extraction on the dried ormosia garment obtained in the step S2, and performing spray drying on the extract to obtain a paclitaxel extract with the purity of more than 99%;
s4. packaging
Filling the paclitaxel extract obtained in S3 into the filling layer and sealing;
s5, post-processing
And sterilizing and packaging the cloth finished product.
Preferably, the pulverization in step S6 is implemented by crushing the solid by overcoming the internal cohesive force of the solid through a mechanical or fluid power method.
Preferably, the filler in step S4 includes Chinese medicinal materials in addition to the paclitaxel extract.
(III) advantageous effects
The invention provides a preparation method and application of a taxol-containing inner core filler and a cloth. The method has the following beneficial effects:
1. the invention provides a preparation application of a taxus chinensis containing paclitaxel inner core filler and a cloth, wherein a filling layer is arranged between a reinforcing layer and a first surface layer of the paclitaxel inner core filler cloth, and paclitaxel extract and traditional Chinese medicines are filled in the filling layer, so that the cloth has strong prevention and anticancer capabilities, and can play a good role in preventing breast cancer when being made into female underwear for use.
2. The invention provides a taxus chinensis containing taxol core filler and a preparation application of a fabric, wherein the surface of the taxol core filler fabric is prepared by compounding a high-molecular waterproof breathable material and a second surface layer, so that the fabric has the advantages of water resistance, moisture permeability, breathability, insulation, warmth retention and the like.
3. The invention provides a preparation application of a taxus chinensis containing paclitaxel inner core filler and a cloth, wherein a base layer of the cloth is made of pure cotton, the elasticity is good, and a reinforcing layer is arranged on the surface of the base layer, so that the mechanical capacity of the paclitaxel inner core filler cloth can be effectively improved, the wear resistance of the paclitaxel inner core filler cloth is enhanced, the service life of the paclitaxel inner core filler cloth is prolonged, and the paclitaxel inner core filler cloth is more reliable to use.
4. The invention provides a taxus chinensis containing paclitaxel inner core filler and a preparation application of a fabric, the paclitaxel inner core filler fabric prepared by the method not only has the functions of prevention and cancer resistance, but also has better elasticity and better wear resistance, the service life of the fabric is greatly prolonged, and the fabric also has the advantages of water resistance, moisture permeability, air permeability, insulation, heat preservation and the like, and has the characteristics of degradability, more convenient use and better anticancer effect.
Drawings
FIG. 1 is a schematic front sectional view of the present invention.
Wherein, 1, a base layer; 2. a bonding layer; 3. a reinforcement layer; 4. a filling layer; 5. a first facing; 6. a second facing.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
as shown in fig. 1, an embodiment of the present invention provides a paclitaxel inner core filler fabric, which includes a base layer 1 and a reinforcing layer 2, an adhesive layer 2 is fixedly disposed between the base layer 1 and the reinforcing layer 3, a filler layer 4 is fixedly disposed on a side of the reinforcing layer 3 away from the adhesive layer 2, a first surface layer 5 is fixedly disposed on a side of the filler layer 4 away from the reinforcing layer 3, and a second surface layer 6 is fixedly disposed on a side of the first surface layer 5 away from the filler layer 4.
The adhesive layer 2 is uniformly coated on the upper surface and the lower surface of the base layer 1, the reinforcing layer 3 and the first surface layer 5 are respectively connected on the upper surface and the lower surface of the filling layer 4 through needling, and the first surface layer 5 and the second surface layer 6 are manufactured in a composite mode.
The material of the sticking layer 2 is PU micropore glue.
The first surface layer 5 is made of macromolecule waterproof and breathable material.
The second facing 6 was made of 70% cotton plus 30% modal and viscose.
The base layer 1 is made of 100% pure cotton.
The preparation method of the paclitaxel inner core filler cloth is characterized by comprising the following steps: the method comprises the following steps:
s1, cleaning and crushing
Cleaning Taxus chinensis, pulverizing branches, stems, leaves, epidermis and roots of Taxus chinensis, and pulverizing to average particle diameter of less than 30 μm;
s2, standing and drying
Testing by a drying method, and drying until the moisture content is less than 5%;
s3, purifying
Performing supercritical extraction on the dried ormosia garment obtained in the step S2, and performing spray drying on the extract to obtain a paclitaxel extract with the purity of more than 99%;
s4. packaging
Filling the paclitaxel extract obtained in S3 into the filling layer 4 and sealing;
s5, post-processing
And sterilizing and packaging the cloth finished product.
The cloth product contains 2kg of paclitaxel extract per square meter.
Example 2:
as shown in fig. 1, an embodiment of the present invention provides a paclitaxel inner core filler fabric, which includes a base layer 1 and a reinforcing layer 2, an adhesive layer 2 is fixedly disposed between the base layer 1 and the reinforcing layer 3, a filler layer 4 is fixedly disposed on a side of the reinforcing layer 3 away from the adhesive layer 2, a first surface layer 5 is fixedly disposed on a side of the filler layer 4 away from the reinforcing layer 3, and a second surface layer 6 is fixedly disposed on a side of the first surface layer 5 away from the filler layer 4.
The adhesive layer 2 is uniformly coated on the upper surface and the lower surface of the base layer 1, the reinforcing layer 3 and the first surface layer 5 are respectively connected on the upper surface and the lower surface of the filling layer 4 through needling, and the first surface layer 5 and the second surface layer 6 are manufactured in a composite mode.
The material of the sticking layer 2 is PU micropore glue.
The first surface layer 5 is made of macromolecule waterproof and breathable material.
The second facing 6 was made of 70% cotton plus 30% modal and viscose.
The base layer 1 is made of 100% pure cotton.
The preparation method of the paclitaxel inner core filler cloth is characterized by comprising the following steps: the method comprises the following steps:
s1, cleaning and crushing
Cleaning Taxus chinensis, pulverizing branches, stems, leaves, epidermis and roots of Taxus chinensis, and pulverizing to average particle diameter of less than 30 μm;
s2, standing and drying
Testing by a drying method, and drying until the moisture content is less than 5%;
s3, purifying
Performing supercritical extraction on the dried ormosia garment obtained in the step S2, and performing spray drying on the extract to obtain a paclitaxel extract with the purity of more than 99%;
s4. packaging
Filling the paclitaxel extract obtained in S3 into the filling layer 4 and sealing;
s5, post-processing
And sterilizing and packaging the cloth finished product.
Each square meter of the finished fabric product contains 2kg of paclitaxel extract and Chinese medicinal materials.
Wherein the Chinese medicinal materials include one or more of fructus Akebiae, radix Paeoniae alba, bupleuri radix, radix Angelicae sinensis, Ecliptae herba, fructus Mussaendae and herba Taraxaci.
Example 3:
as shown in fig. 1, an embodiment of the present invention provides a paclitaxel inner core filler fabric, which includes a base layer 1 and a reinforcing layer 2, an adhesive layer 2 is fixedly disposed between the base layer 1 and the reinforcing layer 3, a filler layer 4 is fixedly disposed on a side of the reinforcing layer 3 away from the adhesive layer 2, a first surface layer 5 is fixedly disposed on a side of the filler layer 4 away from the reinforcing layer 3, and a second surface layer 6 is fixedly disposed on a side of the first surface layer 5 away from the filler layer 4.
The adhesive layer 2 is uniformly coated on the upper surface and the lower surface of the base layer 1, the reinforcing layer 3 and the first surface layer 5 are respectively connected on the upper surface and the lower surface of the filling layer 4 through needling, and the first surface layer 5 and the second surface layer 6 are manufactured in a composite mode.
The material of the sticking layer 2 is PU micropore glue.
The first surface layer 5 is made of macromolecule waterproof and breathable material.
The second facing 6 was made of 70% cotton plus 30% modal and viscose.
The base layer 1 is made of 100% pure cotton.
The preparation method of the paclitaxel inner core filler cloth is characterized by comprising the following steps: the method comprises the following steps:
s1, cleaning and crushing
Cleaning Taxus chinensis, pulverizing branches, stems, leaves, epidermis and roots of Taxus chinensis, and pulverizing to average particle diameter of less than 30 μm;
s2, standing and drying
Testing by a drying method, and drying until the moisture content is less than 5%;
s3, purifying
Performing supercritical extraction on the dried ormosia garment obtained in the step S2, and performing spray drying on the extract to obtain a paclitaxel extract with the purity of more than 99%;
s4. packaging
Filling the paclitaxel extract obtained in S3 into the filling layer 4 and sealing;
s5, post-processing
And sterilizing and packaging the cloth finished product.
The cloth product contains paclitaxel extract 2kg and Chinese medicinal materials 4kg per square meter.
Wherein the Chinese medicinal materials include one or more of fructus Akebiae, radix Paeoniae alba, bupleuri radix, radix Angelicae sinensis, Ecliptae herba, fructus Mussaendae and herba Taraxaci.
Example 4:
as shown in fig. 1, an embodiment of the present invention provides a paclitaxel inner core filler fabric, which includes a base layer 1 and a reinforcing layer 2, an adhesive layer 2 is fixedly disposed between the base layer 1 and the reinforcing layer 3, a filler layer 4 is fixedly disposed on a side of the reinforcing layer 3 away from the adhesive layer 2, a first surface layer 5 is fixedly disposed on a side of the filler layer 4 away from the reinforcing layer 3, and a second surface layer 6 is fixedly disposed on a side of the first surface layer 5 away from the filler layer 4.
The adhesive layer 2 is uniformly coated on the upper surface and the lower surface of the base layer 1, the reinforcing layer 3 and the first surface layer 5 are respectively connected on the upper surface and the lower surface of the filling layer 4 through needling, and the first surface layer 5 and the second surface layer 6 are manufactured in a composite mode.
The material of the sticking layer 2 is PU micropore glue.
The first surface layer 5 is made of macromolecule waterproof and breathable material.
The second facing 6 was made of 70% cotton plus 30% modal and viscose.
The base layer 1 is made of 100% pure cotton.
The preparation method of the paclitaxel inner core filler cloth is characterized by comprising the following steps: the method comprises the following steps:
s1, cleaning and crushing
Cleaning Taxus chinensis, pulverizing branches, stems, leaves, epidermis and roots of Taxus chinensis, and pulverizing to average particle diameter of less than 30 μm;
s2, standing and drying
Testing by a drying method, and drying until the moisture content is less than 5%;
s3, purifying
Performing supercritical extraction on the dried ormosia garment obtained in the step S2, and performing spray drying on the extract to obtain a paclitaxel extract with the purity of more than 99%;
s4. packaging
Filling the paclitaxel extract obtained in S3 into the filling layer 4 and sealing;
s5, post-processing
And sterilizing and packaging the cloth finished product.
The cloth product contains paclitaxel extract 2kg and Chinese medicinal materials 1kg per square meter.
Wherein the Chinese medicinal materials include one or more of fructus Akebiae, radix Paeoniae alba, bupleuri radix, radix Angelicae sinensis, Ecliptae herba, fructus Mussaendae and herba Taraxaci.
Example 5:
as shown in fig. 1, an embodiment of the present invention provides a paclitaxel inner core filler fabric, which includes a base layer 1 and a reinforcing layer 2, an adhesive layer 2 is fixedly disposed between the base layer 1 and the reinforcing layer 3, a filler layer 4 is fixedly disposed on a side of the reinforcing layer 3 away from the adhesive layer 2, a first surface layer 5 is fixedly disposed on a side of the filler layer 4 away from the reinforcing layer 3, and a second surface layer 6 is fixedly disposed on a side of the first surface layer 5 away from the filler layer 4.
The adhesive layer 2 is uniformly coated on the upper surface and the lower surface of the base layer 1, the reinforcing layer 3 and the first surface layer 5 are respectively connected on the upper surface and the lower surface of the filling layer 4 through needling, and the first surface layer 5 and the second surface layer 6 are manufactured in a composite mode.
The material of the sticking layer 2 is PU micropore glue.
The first surface layer 5 is made of macromolecule waterproof and breathable material.
The second facing 6 was made of 70% cotton plus 30% modal and viscose.
The base layer 1 is made of 100% pure cotton.
The preparation method of the paclitaxel inner core filler cloth is characterized by comprising the following steps: the method comprises the following steps:
s1, cleaning and crushing
Cleaning Taxus chinensis, pulverizing branches, stems, leaves, epidermis and roots of Taxus chinensis, and pulverizing to average particle diameter of less than 30 μm;
s2, standing and drying
Testing by a drying method, and drying until the moisture content is less than 5%;
s3, purifying
Performing supercritical extraction on the dried ormosia garment obtained in the step S2, and performing spray drying on the extract to obtain a paclitaxel extract with the purity of more than 99%;
s4. packaging
Filling the paclitaxel extract obtained in S3 into the filling layer 4 and sealing;
s5, post-processing
And sterilizing and packaging the cloth finished product.
The cloth product contains paclitaxel extract 1kg and Chinese medicinal materials 2kg per square meter.
Wherein the Chinese medicinal materials include one or more of fructus Akebiae, radix Paeoniae alba, bupleuri radix, radix Angelicae sinensis, Ecliptae herba, fructus Mussaendae and herba Taraxaci.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (9)
1. Paclitaxel inner core filler cloth, including basic unit (1) and back up coat (3), its characterized in that: it pastes layer (2) to fix being provided with between basic unit (1) and back up coat (3), back up coat (3) are kept away from and are pasted layer (2) one side and fixedly be provided with filling layer (4), reinforcing layer (3) one side is kept away from in filling layer (4) and fixedly be provided with first surface course (5), filling layer (4) one side is kept away from in first surface course (5) and fixedly be provided with second surface course (6).
2. The paclitaxel inner core filler cloth according to claim 1, wherein: the adhesive layer (2) is specifically uniformly coated on the upper surface and the lower surface of the base layer (1), the reinforcing layer (3) and the first surface layer (5) are respectively connected on the upper surface and the lower surface of the filling layer (4) in a needling composite mode, and the first surface layer (5) and the second surface layer (6) are specifically made in a composite mode.
3. The paclitaxel inner core filler cloth according to claim 1, wherein: the material of the sticking layer (2) is PU micropore glue.
4. The paclitaxel inner core filler cloth according to claim 1, wherein: the first surface layer (5) is made of a high-molecular waterproof breathable material.
5. The paclitaxel inner core filler cloth according to claim 1, wherein: the second surface layer (6) is made of 70% of cotton, 30% of modal and viscose.
6. The paclitaxel inner core filler cloth according to claim 1, wherein: the base layer (1) is made of 100% pure cotton.
7. The preparation method of the paclitaxel inner core filler cloth is characterized by comprising the following steps: the method comprises the following steps:
s1, cleaning and crushing
Cleaning Taxus chinensis, pulverizing branches, stems, leaves, epidermis and roots of Taxus chinensis, and pulverizing to average particle diameter of less than 30 μm;
s2, standing and drying
Testing by a drying method, and drying until the moisture content is less than 5%;
s3, purifying
Performing supercritical extraction on the dried ormosia garment obtained in the step S2, and performing spray drying on the extract to obtain a paclitaxel extract with the purity of more than 99%;
s4. packaging
Filling the paclitaxel extract obtained in the step S3 into the filling layer (4) and sealing;
s5, post-processing
And sterilizing and packaging the cloth finished product.
8. The method of preparing a paclitaxel inner core filler cloth according to claim 7, wherein the method comprises the following steps: the pulverization in the step S6 is to overcome the internal cohesive force of the solid by mechanical or fluid power to break the solid.
9. The method of preparing a paclitaxel inner core filler cloth according to claim 7, wherein the method comprises the following steps: the filler in step S4 includes Chinese medicinal materials in addition to the paclitaxel extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110916658.7A CN113619218A (en) | 2021-08-11 | 2021-08-11 | Taxus chinensis filler containing paclitaxel inner core and preparation and application of cloth |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110916658.7A CN113619218A (en) | 2021-08-11 | 2021-08-11 | Taxus chinensis filler containing paclitaxel inner core and preparation and application of cloth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113619218A true CN113619218A (en) | 2021-11-09 |
Family
ID=78384232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110916658.7A Pending CN113619218A (en) | 2021-08-11 | 2021-08-11 | Taxus chinensis filler containing paclitaxel inner core and preparation and application of cloth |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113619218A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204414686U (en) * | 2015-01-22 | 2015-06-24 | 王小珠 | A kind of anticancer fabric |
| CN109605874A (en) * | 2019-01-26 | 2019-04-12 | 江西大晟节能新材股份有限公司 | A kind of novel composite non-woven fabric and its needle pierce preparation method |
| CN111298113A (en) * | 2019-12-05 | 2020-06-19 | 田大伟 | Paclitaxel medicine package and preparation method and application thereof |
-
2021
- 2021-08-11 CN CN202110916658.7A patent/CN113619218A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204414686U (en) * | 2015-01-22 | 2015-06-24 | 王小珠 | A kind of anticancer fabric |
| CN109605874A (en) * | 2019-01-26 | 2019-04-12 | 江西大晟节能新材股份有限公司 | A kind of novel composite non-woven fabric and its needle pierce preparation method |
| CN111298113A (en) * | 2019-12-05 | 2020-06-19 | 田大伟 | Paclitaxel medicine package and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103815076B (en) | Anoectochilus roxburghii health maintenance white tea and preparation method thereof | |
| CN101554198B (en) | Loquat flower tea | |
| CN102415459B (en) | Lily and orange peel tea | |
| CN102550758B (en) | A kind of Ampelopsis grossedentata processing technique | |
| TW200538049A (en) | Compositions for herbal teas enriched with dried plant extracts | |
| CN104886292A (en) | Lily tea and a preparation method thereof | |
| CN102422915A (en) | Mulberry black tea with addition of ordinary black tea and its preparation method | |
| CN102217689A (en) | Preparation method of radix puerariae-rosa roxburghii tratt tea | |
| CN103461914B (en) | A kind of Hyperglycemic health care purple sweet potato cake and production method thereof | |
| CN109329499A (en) | A kind of notoginseng puer tea and preparation method thereof | |
| CN107233599B (en) | Air purifying agent capable of quickly removing metal pollutants in air | |
| CN102422948A (en) | Blood pressure-lowering healthcare tea paste and its preparation method | |
| CN113619218A (en) | Taxus chinensis filler containing paclitaxel inner core and preparation and application of cloth | |
| CN108041596A (en) | A kind of arithoke relieving alcoholism and protecting liver piece and preparation method thereof | |
| CN103976066A (en) | Processing method of pistacia chinensis bunge green tea | |
| CN101438827B (en) | Eaglewood leaf health-care food and preparation method thereof | |
| CN101796990B (en) | Preparation method of pittosporum tobira tea | |
| CN107996761A (en) | A kind of rhizoma Gastrodiae white tea cake and its processing technology | |
| CN104095123A (en) | Cool and refreshing type health-care tea with hippophae rhamnosides leaves and preparation method thereof | |
| CN106035800A (en) | Tea bag of tea capable of moistening skin and beautifying faces | |
| CN101785826A (en) | Thunberg fritillary flower micropowder preparation method | |
| CN111298113A (en) | Paclitaxel medicine package and preparation method and application thereof | |
| Teoh et al. | Genus: Calanthe to Cyrtosia | |
| CN108064989A (en) | A kind of green tea tea bag of lowering blood-fat and reducing weight | |
| CN103271196A (en) | Atractylodes leaf tea and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20211109 |