CN113616543A - Preparation method of wrapped retinol essence - Google Patents
Preparation method of wrapped retinol essence Download PDFInfo
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- CN113616543A CN113616543A CN202111075697.5A CN202111075697A CN113616543A CN 113616543 A CN113616543 A CN 113616543A CN 202111075697 A CN202111075697 A CN 202111075697A CN 113616543 A CN113616543 A CN 113616543A
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- retinol
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- essence
- wrapped
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- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 title claims abstract description 230
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 title claims abstract description 115
- 229960003471 retinol Drugs 0.000 title claims abstract description 115
- 235000020944 retinol Nutrition 0.000 title claims abstract description 115
- 239000011607 retinol Substances 0.000 title claims abstract description 115
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 41
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 claims abstract description 38
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims abstract description 23
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 23
- 229920006037 cross link polymer Polymers 0.000 claims abstract description 22
- 229940108325 retinyl palmitate Drugs 0.000 claims abstract description 19
- 235000019172 retinyl palmitate Nutrition 0.000 claims abstract description 19
- 239000011769 retinyl palmitate Substances 0.000 claims abstract description 19
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229930003799 tocopherol Natural products 0.000 claims abstract description 17
- 239000011732 tocopherol Substances 0.000 claims abstract description 17
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 15
- 235000010445 lecithin Nutrition 0.000 claims abstract description 15
- 239000000787 lecithin Substances 0.000 claims abstract description 15
- 229940067606 lecithin Drugs 0.000 claims abstract description 15
- 229960001295 tocopherol Drugs 0.000 claims abstract description 15
- 235000010384 tocopherol Nutrition 0.000 claims abstract description 15
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims abstract description 15
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims abstract description 14
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims abstract description 13
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims abstract description 13
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000000230 xanthan gum Substances 0.000 claims abstract description 13
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 13
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 13
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 13
- 239000004480 active ingredient Substances 0.000 claims abstract description 5
- 239000002537 cosmetic Substances 0.000 claims abstract description 5
- 239000011159 matrix material Substances 0.000 claims abstract description 5
- 238000002156 mixing Methods 0.000 claims abstract description 5
- 238000003756 stirring Methods 0.000 claims description 31
- 210000002966 serum Anatomy 0.000 claims description 17
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 16
- 238000001514 detection method Methods 0.000 claims description 12
- 238000004806 packaging method and process Methods 0.000 claims description 12
- 239000002994 raw material Substances 0.000 claims description 11
- XPFCZYUVICHKDS-UHFFFAOYSA-N 3-methylbutane-1,3-diol Chemical compound CC(C)(O)CCO XPFCZYUVICHKDS-UHFFFAOYSA-N 0.000 claims description 10
- 238000001816 cooling Methods 0.000 claims description 8
- 239000000839 emulsion Substances 0.000 claims description 8
- 238000011049 filling Methods 0.000 claims description 8
- 229940051250 hexylene glycol Drugs 0.000 claims description 8
- 230000007246 mechanism Effects 0.000 claims description 8
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical group CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 8
- 238000005303 weighing Methods 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 230000008569 process Effects 0.000 claims description 5
- 239000000047 product Substances 0.000 claims description 5
- 229930003427 Vitamin E Natural products 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 4
- 239000003974 emollient agent Substances 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 4
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 230000000813 microbial effect Effects 0.000 claims description 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 4
- 238000004321 preservation Methods 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 239000003381 stabilizer Substances 0.000 claims description 4
- 239000002562 thickening agent Substances 0.000 claims description 4
- 150000003626 triacylglycerols Chemical class 0.000 claims description 4
- 239000011709 vitamin E Substances 0.000 claims description 4
- 235000019165 vitamin E Nutrition 0.000 claims description 4
- 229940046009 vitamin E Drugs 0.000 claims description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 229940043375 1,5-pentanediol Drugs 0.000 claims description 2
- 239000000413 hydrolysate Substances 0.000 claims description 2
- 239000004909 Moisturizer Substances 0.000 claims 1
- 230000002421 anti-septic effect Effects 0.000 claims 1
- 229940064004 antiseptic throat preparations Drugs 0.000 claims 1
- 230000001333 moisturizer Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 10
- 230000007794 irritation Effects 0.000 abstract description 10
- 230000003647 oxidation Effects 0.000 abstract description 5
- 238000007254 oxidation reaction Methods 0.000 abstract description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract description 3
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract description 3
- -1 isopentyl glycol Chemical compound 0.000 abstract description 3
- 235000011187 glycerol Nutrition 0.000 abstract 2
- 239000003755 preservative agent Substances 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 3
- 229940015975 1,2-hexanediol Drugs 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 235000019149 tocopherols Nutrition 0.000 description 2
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a preparation method of a wrapped retinol essence, wherein the wrapped retinol essence is prepared by mixing a component A and a component B, the component A is a cosmetic matrix of the wrapped retinol essence, the component A comprises water, glycerol, alkanol acrylate cross-linked polymer, hexanediol, pentanediol, isopentyl glycol, xanthan gum and dipotassium glycyrrhizinate, the component B is an active ingredient of the wrapped retinol essence, the component B comprises lecithin, triglyceride, retinol palmitate, retinol and tocopherol, and the weight ratio is as follows: 3-8% of glycerin and 0.1-1% of alkanol acrylate cross-linked polymer. The preparation method of the wrapped retinol essence provided by the invention mainly has the advantages that the preparation process is simple, the irritation is low, the activity ratio and the transdermal rate are high, the wrapped retinol can resist oxidation and high temperature, the stability of the formula is greatly improved, and the compatibility is good.
Description
Technical Field
The invention relates to the technical field of skin care product preparation, in particular to a preparation method of a wrapped retinol essence.
Background
The retinol essence is thought to possibly help the skin to be kept in a younger state, help the generation of collagen in the skin to be increased, and enable the skin to look fresh and bright, the retinol essence used in the current market still has the defects in the using process, the irritation is large, a user is easy to have symptoms such as allergic peeling and the like, sensitive muscles need to be used carefully, the stability is poor, the retinol in the formula is easy to be oxidized, the activity is lost, the permeability is poor, the transdermal absorbability of the retinol in the common visual formula is poor, and the formula efficacy is also reduced, so that a preparation method for wrapping the retinol essence is provided.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a preparation method of wrapped retinol essence.
In order to achieve the purpose, the invention adopts the following technical scheme:
the wrapping retinol essence is prepared by mixing a component A and a component B, wherein the component A is a cosmetic matrix of the wrapping retinol essence, the component A comprises water, glycerol, alkanol acrylate cross-linked polymer, hexanediol, pentanediol, isoprene glycol, xanthan gum and dipotassium glycyrrhizinate, the component B is an active ingredient of the wrapping retinol essence, the component B comprises lecithin, triglyceride, retinol palmitate, retinol and tocopherol, and the weight ratio of the components B is as follows: 3-8% of glycerol, 0.1-1% of alkanol acrylate cross-linked polymer, 0.5-2% of hexanediol, 0.5-5% of pentanediol, 1-5% of isoprene glycol, 0.05-0.2% of xanthan gum, 0.02-0.2% of dipotassium glycyrrhizinate, 0.1-5% of lecithin, 0.1-5% of triglyceride, 0.1-3% of retinol palmitate, 0.1-3% of retinol, 0.05-1% of tocopherol and the balance of water.
As a further aspect of the invention, the alkanol acrylate cross-linked polymer is a film former that acts as a stabilizer and thickener in the encapsulated retinol serum, which is embodied as a (ester) acrylate/C10-30 alkanol acrylate cross-linked polymer.
As a further aspect of the present invention, the hexylene glycol and the pentylene glycol function as a moisturizing agent and a novel preservative in the encapsulated retinol serum, and the hexylene glycol is embodied as 1, 2-hexylene glycol, and the pentylene glycol is embodied as 1, 2-pentylene glycol.
As a further aspect of the invention, the triglyceride acts as an emollient and a solvent in the encapsulated retinol serum, and is embodied as caprylic/capric triglyceride.
As a further aspect of the invention, the tocopherol is a hydrolysate of vitamin E.
A preparation method of wrapped retinol essence comprises the following steps:
s1, weighing the corresponding parts of the component A, namely water, glycerol, alkanol acrylate cross-linked polymer, hexanediol, pentanediol, isoprene glycol, xanthan gum and dipotassium glycyrrhizinate according to the parts by weight, putting the weighed component A into a stirring mechanism, heating to 70-80 ℃, stirring, cooling to 40-50 ℃ after stirring until no particles exist, and preparing a transparent viscous liquid-shaped component A;
s2, weighing corresponding parts of B component lecithin, triglyceride, retinol palmitate, retinol and tocopherol raw materials according to the weight parts, then putting the weighed B component raw materials into a stirring mechanism, stirring at the temperature of 25-45 ℃, keeping the pressure at 0.5-2 MPa, homogenizing at high speed, observing the mixed microstructure of the B phase, and ensuring that the grain size of the B phase is uniform and has no obvious difference, thus preparing the B phase component;
s3, adding the prepared phase B component into the phase A component to fuse the phase A component and the phase B component, and stirring the phase A component and the phase B component to homogenize the phase A component and the phase B component;
s4, stirring the component A and the component B until the components A and B are uniform and granular, keeping the temperature at 40-50 ℃ for 30min, and obtaining the emulsion wrapped retinol essence after the temperature is kept;
s5, immediately cooling the prepared emulsion wrapped retinol essence to 35 ℃ after the heat preservation time is reached, then detecting the viscosity, density, pH value and appearance of the prepared wrapped retinol essence, and discharging after the detection is qualified;
s6, carrying out microbial detection on the packaged retinol essence of the discharged material, taking out the liquid after the detection is qualified, flowing into a packaging container through a pipeline according to a certain flow speed and flow, wherein the movement of fluid in the pipeline in the flowing-in process depends on the pressure difference between an inflow end and an outflow end, the pressure of the inflow end is necessarily higher than that of the outflow end, filling the packaged retinol essence, and after the filling is finished, packaging the packaged retinol essence by adopting a demand packaging mode to obtain a packaged retinol essence finished product.
As a further aspect of the invention, the agitation involved in said step S1 is 600 rpm.
As a further scheme of the invention, the stirring and homogenizing in the step S3 are carried out at 45rpm, 3000rpm and 5-10 min.
Compared with the prior art, the invention has the beneficial effects that: the preparation method of the retinol-coated essence provided by the invention is mainly characterized by simple preparation process and low raw material cost, the irritation of retinol is reduced by coating retinol in advance, and the retinol palmitate with low irritation is coated and converted into retinol in vivo, so that the activity ratio is improved, the retinol and the retinol palmitate are pretreated, so that the oxidation resistance and high temperature resistance of the coated retinol are improved, the stability of the formula is greatly improved, the retinol-coated lecithin has good compatibility with the skin cuticle, the skin penetration rate is higher, and the using effect is good.
In summary, the preparation method of the wrapped retinol essence is simple in preparation process, low in irritation, high in activity ratio and transdermal rate, and capable of improving the oxidation resistance and high temperature resistance of the wrapped retinol, so that the stability of the formula is greatly improved, and the compatibility is good.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1
A wrapped retinol essence is prepared by mixing a component A and a component B, wherein the component A is a cosmetic matrix of the wrapped retinol essence, the component A comprises water, glycerol, alkanol acrylate cross-linked polymer, hexanediol, pentanediol, isopentyl glycol, xanthan gum and dipotassium glycyrrhizinate, the component B is an active ingredient of the wrapped retinol essence, and the component B comprises lecithin, triglyceride, retinol palmitate, retinol and tocopherol, and is prepared by the following weight ratio: 3% of glycerol, 0.1% of alkanol acrylate cross-linked polymer, 0.5% of hexanediol, 0.5% of pentanediol, 1% of isoprene glycol, 0.05% of xanthan gum, 0.02% of dipotassium glycyrrhizinate, 0.1% of lecithin, 0.1% of triglyceride, 0.1% of retinol palmitate, 0.1% of retinol, 0.05% of tocopherol and the balance of water.
The alkanol acrylate cross-linked polymer is a film forming agent which acts as a stabilizer and a thickener in the encapsulated retinol serum, and is embodied as an acrylic acid/C10-30 alkanol acrylate cross-linked polymer.
The hexylene glycol and the pentanediol act as a humectant and a novel preservative in the wrapped retinol essence, and the hexylene glycol is embodied as 1, 2-hexanediol, and the pentanediol is embodied as 1, 2-pentanediol.
Triglycerides act as emollients and solvents in the encapsulated retinol serum and are embodied as caprylic/capric triglyceride.
Tocopherols are hydrolysates of vitamin E.
A preparation method of wrapped retinol essence comprises the following steps:
s1, weighing the corresponding parts of the component A water, the glycerol, the alkanol acrylate cross-linked polymer, the hexanediol, the pentanediol, the isoprene glycol, the xanthan gum and the dipotassium glycyrrhizinate according to the parts by weight, then putting the weighed component A into a stirring mechanism, heating to 70 ℃, stirring at 600rpm, cooling to 40 ℃ after stirring until no particles exist, and preparing the transparent viscous liquid-shaped component A;
s2, weighing corresponding parts of B component lecithin, triglyceride, retinol palmitate, retinol and tocopherol raw materials according to the weight parts, then putting the weighed B component raw materials into a stirring mechanism, stirring at 25 ℃, keeping the pressure at 0.5MPa, homogenizing at high speed, observing the mixed microstructure of the B phase, ensuring that the particle size of the B phase is uniform and has no clear difference, and preparing the B phase component at the moment, thereby wrapping the retinol and the retinol palmitate, reducing irritation, and improving the activity proportion and the transdermal rate;
s3, adding the prepared phase B component into the phase A component to fuse the phase A component and the phase B component, stirring the phase A component and the phase B component at 45rpm, and homogenizing at 3000rpm for 5 min;
s4, stirring the component A and the component B until the components A and B are uniform and granular, preserving the heat at 40 ℃ for 30min to obtain emulsion wrapped retinol essence;
s5, immediately cooling the prepared emulsion wrapped retinol essence to 35 ℃ after the heat preservation time is reached, then detecting the viscosity, density, pH value and appearance of the prepared wrapped retinol essence, and discharging after the detection is qualified;
s6, carrying out microbial detection on the packaged retinol essence of the discharged material, taking out the liquid after the detection is qualified, flowing into a packaging container through a pipeline according to a certain flow speed and flow, wherein the movement of fluid in the pipeline in the flowing-in process depends on the pressure difference between an inflow end and an outflow end, the pressure of the inflow end is necessarily higher than that of the outflow end, filling the packaged retinol essence, and after the filling is finished, packaging the packaged retinol essence by adopting a demand packaging mode to obtain a packaged retinol essence finished product.
Example 2
A wrapped retinol essence is prepared by mixing a component A and a component B, wherein the component A is a cosmetic matrix of the wrapped retinol essence, the component A comprises water, glycerol, alkanol acrylate cross-linked polymer, hexanediol, pentanediol, isopentyl glycol, xanthan gum and dipotassium glycyrrhizinate, the component B is an active ingredient of the wrapped retinol essence, and the component B comprises lecithin, triglyceride, retinol palmitate, retinol and tocopherol, and is prepared by the following weight ratio: 8% of glycerol, 1% of alkanol acrylate cross-linked polymer, 2% of hexanediol, 5% of pentanediol, 5% of isoprene glycol, 0.2% of xanthan gum, 0.2% of dipotassium glycyrrhizinate, 5% of lecithin, 5% of triglyceride, 3% of retinol palmitate, 3% of retinol, 1% of tocopherol and the balance of water.
The alkanol acrylate cross-linked polymer is a film forming agent which acts as a stabilizer and a thickener in the encapsulated retinol serum, and is embodied as an acrylic acid/C10-30 alkanol acrylate cross-linked polymer.
The hexylene glycol and the pentanediol act as a humectant and a novel preservative in the wrapped retinol essence, and the hexylene glycol is embodied as 1, 2-hexanediol, and the pentanediol is embodied as 1, 2-pentanediol.
Triglycerides act as emollients and solvents in the encapsulated retinol serum and are embodied as caprylic/capric triglyceride.
Tocopherols are hydrolysates of vitamin E.
A preparation method of wrapped retinol essence comprises the following steps:
s1, weighing the corresponding parts of the component A water, the glycerol, the alkanol acrylate cross-linked polymer, the hexanediol, the pentanediol, the isoprene glycol, the xanthan gum and the dipotassium glycyrrhizinate according to the parts by weight, then putting the weighed component A into a stirring mechanism, heating to 80 ℃, stirring at 600rpm, cooling to 50 ℃ after stirring until no particles exist, and then preparing the transparent viscous liquid-shaped component A;
s2, weighing corresponding parts of B component lecithin, triglyceride, retinol palmitate, retinol and tocopherol raw materials according to the parts by weight, then putting the weighed B component raw materials into a stirring mechanism, stirring at 45 ℃, keeping the pressure at 2Mpa, homogenizing at high speed, observing the mixed microstructure of the B phase, ensuring that the particle size of the B phase is uniform and has no clear difference, and preparing the B phase component at the moment, thereby wrapping the retinol and the retinol palmitate, reducing the irritation, and improving the activity proportion and the transdermal rate;
s3, adding the prepared phase B component into the phase A component to fuse the phase A component and the phase B component, stirring the phase A component and the phase B component at 45rpm, and homogenizing at 3000rpm for 10 min;
s4, stirring the component A and the component B until the components A and B are uniform and granular, keeping the temperature at 50 ℃ for 30min, and obtaining the wrapping retinol essence in an emulsion state after the temperature is kept;
s5, immediately cooling the prepared emulsion wrapped retinol essence to 35 ℃ after the heat preservation time is reached, then detecting the viscosity, density, pH value and appearance of the prepared wrapped retinol essence, and discharging after the detection is qualified;
s6, carrying out microbial detection on the packaged retinol essence of the discharged material, taking out the liquid after the detection is qualified, flowing into a packaging container through a pipeline according to a certain flow speed and flow, wherein the movement of fluid in the pipeline in the flowing-in process depends on the pressure difference between an inflow end and an outflow end, the pressure of the inflow end is necessarily higher than that of the outflow end, filling the packaged retinol essence, and after the filling is finished, packaging the packaged retinol essence by adopting a demand packaging mode to obtain a packaged retinol essence finished product.
The formulation of the encapsulated retinol serum referred to in the above examples is shown in table 1 below:
table 1: raw material proportioning table for wrapped retinol essence
The embodiment shows that the preparation method of the retinol-coated essence provided by the invention mainly has the advantages that the preparation process is simple, the cost of raw materials is low, the irritation of the retinol is reduced by coating the retinol in advance, the retinol palmitate with low irritation is coated at the same time, the retinol is converted into the retinol in vivo, the activity ratio is improved, the retinol and the retinol palmitate are pre-treated, the oxidation resistance and high temperature resistance of the coated retinol are improved, the stability of the formula is greatly improved, the retinol-coated lecithin has good compatibility with the skin cuticle, the skin penetration rate is higher, and the using effect is good.
In conclusion, the preparation method of the retinol-coated essence is simple in preparation process, low in irritation, high in activity ratio and transdermal rate, and capable of improving the oxidation resistance and high temperature resistance of the coated retinol, so that the stability of the formula is greatly improved, and the compatibility is good.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be able to cover the technical scope of the present invention and the equivalent alternatives or modifications according to the technical solution and the inventive concept of the present invention within the technical scope of the present invention.
Claims (8)
1. The wrapped retinol essence is characterized in that the wrapped retinol essence is prepared by mixing a component A and a component B, wherein the component A is a cosmetic matrix of the wrapped retinol essence, the component A comprises water, glycerol, alkanol acrylate cross-linked polymer, hexanediol, pentanediol, isoprene glycol, xanthan gum and dipotassium glycyrrhizinate, the component B is an active ingredient of the wrapped retinol essence, the component B comprises lecithin, triglyceride, retinol palmitate, retinol and tocopherol, and the wrapped retinol essence comprises the following components in parts by weight: 3-8% of glycerol, 0.1-1% of alkanol acrylate cross-linked polymer, 0.5-2% of hexanediol, 0.5-5% of pentanediol, 1-5% of isoprene glycol, 0.05-0.2% of xanthan gum, 0.02-0.2% of dipotassium glycyrrhizinate, 0.1-5% of lecithin, 0.1-5% of triglyceride, 0.1-3% of retinol palmitate, 0.1-3% of retinol, 0.05-1% of tocopherol and the balance of water.
2. The encapsulated retinol serum in accordance with claim 1, wherein the cross-linked polymer of alkanol acrylate is a film forming agent, which acts as a stabilizer and a thickener in the encapsulated retinol serum, which is embodied as acrylic acid/C10-30 alkanol acrylate cross-linked polymer.
3. The encapsulated retinol serum in accordance with claim 1, wherein said hexylene glycol and pentylene glycol function as moisturizer and novel antiseptics in the encapsulated retinol serum, and said hexylene glycol is embodied by 1, 2-hexylene glycol, and said pentylene glycol is embodied by 1, 2-pentylene glycol.
4. The encapsulated retinol serum in accordance with claim 1, wherein the triglycerides act as emollients and solvents in the encapsulated retinol serum, and are embodied as caprylic/capric triglycerides.
5. The encapsulated retinol serum in accordance with claim 1, wherein the tocopherol is a hydrolysate of vitamin E.
6. The preparation method of the wrapped retinol essence as claimed in claim 1, which comprises the following steps:
s1, weighing the corresponding parts of the component A, namely water, glycerol, alkanol acrylate cross-linked polymer, hexanediol, pentanediol, isoprene glycol, xanthan gum and dipotassium glycyrrhizinate according to the parts by weight, putting the weighed component A into a stirring mechanism, heating to 70-80 ℃, stirring, cooling to 40-50 ℃ after stirring until no particles exist, and preparing a transparent viscous liquid-shaped component A;
s2, weighing corresponding parts of B component lecithin, triglyceride, retinol palmitate, retinol and tocopherol raw materials according to the weight parts, then putting the weighed B component raw materials into a stirring mechanism, stirring at the temperature of 25-45 ℃, keeping the pressure at 0.5-2 MPa, homogenizing at high speed, observing the mixed microstructure of the B phase, and ensuring that the grain size of the B phase is uniform and has no obvious difference, thus preparing the B phase component;
s3, adding the prepared phase B component into the phase A component to fuse the phase A component and the phase B component, and stirring the phase A component and the phase B component to homogenize the phase A component and the phase B component;
s4, stirring the component A and the component B until the components A and B are uniform and granular, keeping the temperature at 40-50 ℃ for 30min, and obtaining the emulsion wrapped retinol essence after the temperature is kept;
s5, immediately cooling the prepared emulsion wrapped retinol essence to 35 ℃ after the heat preservation time is reached, then detecting the viscosity, density, pH value and appearance of the prepared wrapped retinol essence, and discharging after the detection is qualified;
s6, carrying out microbial detection on the packaged retinol essence of the discharged material, taking out the liquid after the detection is qualified, flowing into a packaging container through a pipeline according to a certain flow speed and flow, wherein the movement of fluid in the pipeline in the flowing-in process depends on the pressure difference between an inflow end and an outflow end, the pressure of the inflow end is necessarily higher than that of the outflow end, filling the packaged retinol essence, and after the filling is finished, packaging the packaged retinol essence by adopting a demand packaging mode to obtain a packaged retinol essence finished product.
7. The wrapped retinol serum in accordance with claim 6, wherein the stirring in step S1 is 600 rpm.
8. The wrapped retinol serum in accordance with claim 6, wherein the stirring and homogenizing in step S3 is 45rpm, 3000rpm, and the homogenizing time is 5-10 min.
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| CN114869798A (en) * | 2022-05-17 | 2022-08-09 | 广东丸美生物技术股份有限公司 | Anti-allergy formula with high content of retinol, high content of retinol cosmetics and preparation method thereof |
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| CN112915043A (en) * | 2021-02-07 | 2021-06-08 | 深圳市护家科技有限公司 | Method for wrapping and stabilizing retinoid and application thereof |
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