CN114869798B - Antiallergic formula with high retinol content, high retinol content cosmetic Huang Chunhua and preparation method thereof - Google Patents
Antiallergic formula with high retinol content, high retinol content cosmetic Huang Chunhua and preparation method thereof Download PDFInfo
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- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 title claims abstract description 319
- 239000011607 retinol Substances 0.000 title claims abstract description 161
- 229960003471 retinol Drugs 0.000 title claims abstract description 161
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 title claims abstract description 160
- 235000020944 retinol Nutrition 0.000 title claims abstract description 160
- 239000002537 cosmetic Substances 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 230000003266 anti-allergic effect Effects 0.000 title abstract description 70
- 230000000007 visual effect Effects 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 238000010438 heat treatment Methods 0.000 claims description 8
- 238000005086 pumping Methods 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 6
- 230000001804 emulsifying effect Effects 0.000 claims description 4
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- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 2
- 229940035437 1,3-propanediol Drugs 0.000 claims description 2
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims description 2
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims description 2
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- 235000010385 ascorbyl palmitate Nutrition 0.000 claims description 2
- VKIJBOMCWLTQBD-UHFFFAOYSA-N benzoic acid N-(2-hydroxyphenyl)propanamide Chemical compound C(C1=CC=CC=C1)(=O)O.C(CC)(=O)NC1=C(C=CC=C1)O VKIJBOMCWLTQBD-UHFFFAOYSA-N 0.000 claims description 2
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- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
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- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 abstract description 56
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 abstract description 28
- 229960000458 allantoin Drugs 0.000 abstract description 28
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 abstract description 27
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 abstract description 27
- 239000004533 oil dispersion Substances 0.000 abstract description 14
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- 239000004322 Butylated hydroxytoluene Substances 0.000 description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
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- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
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- 229940068977 polysorbate 20 Drugs 0.000 description 2
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- LVDXDNDMOQYDMZ-UHFFFAOYSA-N 2-[2-(2-phenylmethoxypropoxy)propoxy]propyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCC(C)OCC(C)OCC(C)OCc1ccccc1 LVDXDNDMOQYDMZ-UHFFFAOYSA-N 0.000 description 1
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- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
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- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
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- 239000008120 corn starch Substances 0.000 description 1
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- 238000011161 development Methods 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 230000006058 immune tolerance Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
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- 229940105132 myristate Drugs 0.000 description 1
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- 210000000929 nociceptor Anatomy 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229940095106 ppg-3 benzyl ether myristate Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
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- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- 239000001841 zingiber officinale Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The application relates to the technical field of cosmetics, in particular to an anti-allergic formula with high retinol content, a high-content visual Huang Chunhua cosmetic and a preparation method thereof. The antiallergic formula retinol is prepared by dispersing and coating retinol or water-soluble and coated retinol; the weight portions are as follows: oil dispersion encapsulates retinol: 0.5-2.5; or water-soluble encapsulated retinol: 0.5-3; the anti-allergic component comprises: a first anti-allergic component and a second anti-allergic component; the first anti-allergic component comprises dipotassium glycyrrhizinate: 0.05-0.25; allantoin: 0.05-0.25; the second anti-allergic component is SENS' FLOWERSD-SC,100 or
Description
Technical Field
The application relates to the technical field of cosmetics, in particular to an anti-allergic formula with high retinol content, a high-content visual Huang Chunhua cosmetic and a preparation method thereof.
Background
Social development has so far, from ancient rouge blush to the present cosmetics gradually become daily necessities of people, people never stop the pace of beauty pursuit, but are anti-aging, undoubtedly the permanent principal angle therein.
Currently, there are several major main streams of anti-aging cosmetics classified from functional substances, namely collagen, peptide, retinol, antioxidants and some plant extracts. Retinol inhibits tyrosinase, thereby inhibiting melanin production; can promote metabolism of cells, make aged cutin peel off more quickly, and make skin fine and smooth; can resist photoaging and avoid free radical damage caused by ultraviolet rays; meanwhile, the composition can act on fibroblasts and strengthen elastin fibers in human bodies, and has the anti-wrinkle effect. Because of the outstanding efficacy of retinol, in the anti-aging field, retinol always exists as a lever of the anti-aging world.
However, generally, highly active functional substances often have pain points that are difficult to overcome. Retinol has two recognized pain points, respectively:
1. stability of
The structure according to Huang Chunhua has more unsaturated bonds, can resist photoaging, and the structure and efficacy determine that the stability of retinol is not good. Thus, in terms of structure, more of the commercial retinol is present as a retinol modification, retinol ester, thereby improving the stability of retinol. Regarding the problem of light stability, the protection of retinol is mainly carried out in the market in a wrapping mode, and the wrapping modes can be divided into water-soluble wrapping modes, oil-soluble dispersing modes and the like according to different wrapping modes.
2. Irritation (irritation)
Since a large mechanism of action of retinol is the conversion of retinol to retinoic acid on the skin via a series of processes, the metabolism of keratinocytes is promoted, which is supposed to be highly irritating although the efficacy of retinol is good.
In order to reduce the irritation of retinol in the market at present, two general treatment methods exist, namely, firstly, the consumption of retinol is reduced (the common consumption of retinol is about 0.02 percent calculated by single retinol), but the method is likely to lead the added retinol to not reach the effective amount, thereby greatly reducing the efficacy of the product; second, long-term use of retinol products, and gradually increasing the amount of retinol, allows the skin to build up immune tolerance.
Disclosure of Invention
The embodiment of the application aims to provide an anti-allergic formula with high retinol content, a cosmetic with high retinol content and a preparation method thereof.
In a first aspect, the present application provides an anti-sensitization formulation comprising a high level of retinol, comprising retinol and an anti-sensitization component, wherein the retinol is selected from the group consisting of oil-dispersed encapsulated retinol and water-soluble encapsulated retinol; the weight portions are as follows: oil dispersion encapsulates retinol: 0.5-2.5; or water-soluble encapsulated retinol: 0.5-3;
the anti-allergic component comprises: a first anti-allergic component and a second anti-allergic component; the first anti-allergic component comprises dipotassium glycyrrhizinate: 0.05-0.25; allantoin: 0.05-0.25;
the second anti-allergic component is SENS' FLOWER SD-SC,100 or->At least one of them.
The scheme of the application aims at pain points of retinol, utilizes oil to disperse and wrap retinol or water-soluble wrapped retinol to overcome unstable short plates of retinol, and establishes a strong anti-sensitization system in a formula at the same time, so that retinol can be added into products with high content, and the irritation of the products is reduced. In the scheme of the application, when the retinol is coated by oil dispersion, the content of the retinol can reach 0.5 to 2.5; when water-soluble coated retinol is used, the content can be as high as 0.5-3.
In other embodiments of the application, the second anti-allergic component is selected from SENS' FLOWER SD-SC, in an amount ranging from 0 to 5, and is not zero.
In other embodiments of the application, the second anti-allergic component is selected100, the content of which is in the range of 0-0.5 and is not zero.
In other embodiments of the application, the second anti-allergic component is selectedThe content is in the range of 0-0.5 and is not zero.
In other embodiments of the application, the retinol is selected from water-soluble encapsulated retinol; the second anti-allergic component is selected from SENS 'FLOWER SD-SC, optionally SENS' FLOWER SD-SC, and its content is in the range of 0-5, and is not zero.
In other embodiments of the application, the retinol is selected from water-soluble encapsulated retinol; the content of the water-soluble wrapped retinol is more than or equal to 2.3; the second anti-allergic component is selected from SENS' FLOWER SD-SC andalternatively, SENS' FLOWER SD-SC, in an amount in the range of 0-5, is non-zero; />The content is in the range of 0-0.5 and is not zero.
In other embodiments of the application, the retinol is selected from the group consisting of oil dispersion coated retinol and the second anti-allergic component is selected from the group consisting of SENS 'FLOWER SD-SC, optionally SENS' FLOWER SD-SC, in an amount in the range of 0-5, and non-zero.
In other embodiments of the present application, the retinol is selected from oil-dispersed encapsulated retinol, wherein the content of the oil-dispersed encapsulated retinol is 2 or more; the second anti-allergic component is selected from SENS' FLOWER SD-SC and100, optionally, SENS' FLOWER SD-SC, in an amount in the range of 0-5, and other than zero; second antiallergic component selection->100, the content of which is in the range of 0-0.5 and is not zero.
In a second aspect, the present application provides a high-content visual Huang Chunhua cosmetic, the formulation of which is an anti-sensitization formulation incorporating any of the high-content retinol described above.
In a third aspect, the present application provides a method for preparing a high content visual Huang Chunhua cosmetic comprising:
the cosmetic comprises phase A, phase B and phase E; the weight portions are as follows:
the phase A comprises: dipotassium glycyrrhizinate: 0.05-0.25; allantoin: 0.05-0.25;
the phase B comprises: an oil phase component; optionally oil-dispersed encapsulated retinol; oil dispersion encapsulates retinol: 0.5-2.5;
the E phase comprises: SENS' FLOWER SD-SC:0-5;100：0-0.5；/>0-0.5, and SENS' FLOWER SD-SC,/L>100、/>At least one of the three is not zero; optionally water-soluble encapsulation of retinol; water-soluble encapsulation of retinol: 0.5-3;
when phase E includes water-soluble encapsulated retinol, phase B does not include oil dispersed encapsulated retinol; when the phase B contains oil-dispersed encapsulated retinol, the phase E does not contain water-soluble encapsulated retinol;
the preparation method comprises the following steps:
adding phase A into a water phase pot, heating to 70-90 ℃, and preserving heat;
adding phase B into oil phase pot, heating to 70-90deg.C, and keeping the temperature;
pumping the water phase into an emulsifying pot, pumping into an oil phase, and homogenizing;
cooling to 35-50deg.C, and adding phase E.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present application more apparent, the technical solutions in the embodiments of the present application will be clearly and completely described below, and it is apparent that the described embodiments are some embodiments of the present application, but not all embodiments.
Accordingly, the following detailed description of the embodiments of the application is not intended to limit the scope of the application, as claimed, but is merely representative of selected embodiments of the application. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
Some embodiments of the present application provide an anti-sensitization formulation with high levels of retinol, comprising retinol and an anti-sensitization component, wherein the retinol is selected from the group consisting of oil-dispersed encapsulated retinol and water-soluble encapsulated retinol; the weight portions are as follows: oil dispersion encapsulates retinol: 0.5-2.5; or water-soluble encapsulated retinol: 0.5-3.
Further, the anti-allergic component includes: a first anti-allergic component and a second anti-allergic component; the first anti-allergic component comprises dipotassium glycyrrhizinate: 0.05-0.25; allantoin: 0.05-0.25.
Further, the second anti-allergic component comprises SENS' FLOWER SD-SC,100 orAt least one of them.
Further alternatively, in some embodiments of the present application, in the above-described high retinol content antiallergic formulation, the components are as follows: comprising oil dispersion encapsulation of retinol: 0.6-2.4; further alternatively, in some embodiments of the present application, in the above-described high retinol content antiallergic formulation, the components are as follows: comprising oil dispersion encapsulation of retinol: 0.7-2.3; further alternatively, in some embodiments of the present application, in the above-described high retinol content antiallergic formulation, the components are as follows: comprising oil dispersion encapsulation of retinol: 0.8-2.2.
Illustratively, in an anti-sensitization formulation with high retinol content, the anti-sensitization formulation comprises the following components in parts by mass: comprising oil dispersion encapsulation of retinol: 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1 or 2.2.
Further alternatively, in some embodiments of the present application, in the above-described high retinol content antiallergic formulation, the components are as follows: comprising water-soluble encapsulated retinol: 0.6-2.9; further alternatively, in some embodiments of the present application, in the above-described high retinol content antiallergic formulation, the components are as follows: comprising water-soluble encapsulated retinol: 0.7-2.8; further alternatively, in some embodiments of the present application, in the above-described high retinol content antiallergic formulation, the components are as follows: comprising water-soluble encapsulated retinol: 0.8-2.7.
Illustratively, in an anti-sensitization formulation with high retinol content, the anti-sensitization formulation comprises the following components in parts by mass: comprising water-soluble encapsulated retinol: 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5 or 2.6.
The above oil dispersion coated Retinol is commercially available, and for example, multisal Retinol is selected, and its composition includes silica, PPG-3 benzyl ether myristate, retinol, polysorbate-20, polyethyleneimine-10, butylated hydroxytoluene, butylated hydroxyanisole, laurate, corn (ZEA MAYS) starch, hydrolyzed corn starch octenyl succinate, and Retinol content of 10wt%.
It should also be noted that the above water-soluble encapsulated Retinol is commercially available, for example, anallerg- -Retinol-10C is selected from the group consisting of Retinol, water, polysorbate-20, caprylic/capric triglyceride, glycerol, lauroyl arginine ethyl ester hydrochloride, polyglyceryl-10 myristate, butylated hydroxytoluene, butylated hydroxyanisole; the retinol content was 9.5wt%.
Further, in some embodiments of the application, the second anti-allergic component described above is selected from SENS' FLOWER SD-SC, which is present in an amount ranging from 0 to 5 and is not zero.
Further alternatively, in some embodiments of the application, the second anti-allergic component described above in the high retinol content anti-allergic formulation is selected from the group consisting of SENS' FLOWER SD-SC, in an amount ranging from 0.01 to 4.99; further alternatively, the second anti-allergic component is selected from SENS' FLOWER SD-SC, and the content thereof is in the range of 0.1-4.9; further alternatively, the second antiallergic component described above is selected from SENS' FLOWER SD-SC, and its content is in the range of 1-4.
Illustratively, in an anti-sensitization formulation with high retinol content, the anti-sensitization formulation comprises the following components in parts by mass: the second anti-allergic component is SENS' FLOWER SD-SC, and the content is as follows: 0.5, 1.1, 1.5, 1.8, 2.0, 2.5, 3.0, 3.5, 4.0 or 4.5.
The SENS' FLOWER SD-SC is commercially available and generally comprises the following components: water, 1, 3-propanediol, CROCUS SATIVUS (CROCUS SATIVUS) flower extract.
Further, in some embodiments of the application, the second anti-allergic component described above is selected in an anti-allergic formulation having a high retinol content100, the content of which is in the range of 0-0.5 and is not zero.
Further alternatively, the second anti-allergic component described above is selected100, the content of which is in the range of 0.01-0.49; further alternatively, the second anti-allergic component mentioned above is selected from->100, the content of which is in the range of 0.02-0.48. Further alternatively, the second anti-allergic component mentioned above is selected from->100, the content of which is in the range of 0.03-0.47.
Illustratively, in an anti-sensitization formulation with high retinol content, the anti-sensitization formulation comprises the following components in parts by mass: selection of a second anti-allergic component100, the content of which is: 0.1, 0.2, 0.3, 0.4 or 0.5.
The above-mentioned100 is commercially available and generally comprises the following components: bisabolol, ginger (ZINGIBER OFFICINALE) root extract.
Further, in some embodiments of the application, the second anti-allergic component described above is selected in an anti-allergic formulation having a high retinol contentThe content is in the range of 0-0.5 and is not zero.
Further alternatively, the second anti-allergic component described above is selectedThe content is in the range of 0.01-0.49; further alternatively, the second anti-allergic component mentioned above is selected from->The content is in the range of 0.02-0.48. Further alternatively, the second anti-allergic component mentioned above is selected from->The content is in the range of 0.03-0.47.
Illustratively, in an anti-sensitization formulation with high retinol content, the anti-sensitization formulation comprises the following components in parts by mass: selection of a second anti-allergic componentThe content of the components is as follows: 0.1, 0.2, 0.3, 0.4 or 0.5.
The above-mentionedCan be purchased commercially and generally comprises the ingredientsThe method comprises the following steps: butanediol, 1, 2-pentanediol, hydroxyphenyl propionamide benzoic acid, ascorbyl palmitate.
Further, in some embodiments of the application, the retinol is selected from water-soluble encapsulated retinol; selection of a second anti-allergic componentAlternatively, SENS' FLOWER SD-SC is present in an amount in the range of 0-5 and is non-zero.
In some embodiments of the application, the retinol is selected from water-soluble encapsulated retinol; the second anti-allergic component is selected from SENS 'FLOWER SD-SC, optionally SENS' FLOWER SD-SC, and its content is in the range of 0-5, and is not zero.
In some embodiments of the application, the retinol is selected from water-soluble encapsulated retinol; the content of the water-soluble wrapped retinol is more than or equal to 2.3; the second anti-allergic component is selected from SENS' FLOWER SD-SC andalternatively, SENS' FLOWER SD-SC, in an amount in the range of 0-5, is non-zero; />The content is in the range of 0-0.5 and is not zero.
In some embodiments of the application, the retinol is selected from the group consisting of oil dispersion coated retinol and the second anti-allergic component is selected from the group consisting of SENS 'FLOWER SD-SC, optionally SENS' FLOWER SD-SC, in an amount in the range of 0-5, and non-zero.
In some embodiments of the application, the retinol is selected from oil-dispersed coated retinol having a content of 2 or more; the second anti-allergic component is selected from SENS' FLOWER SD-SC and100, optionally, SENS' FLOWER SD-SC, in an amount in the range of 0-5, and other than zero; second antiallergic component selection->100, the content of which is in the range of 0-0.5 and is not zero.
Some embodiments of the present application provide a high-content visual Huang Chunhua cosmetic, in which the formulation of the cosmetic is formulated with the high-retinol anti-sensitization formulation provided in any of the previous embodiments.
Some embodiments of the present application provide a method for preparing a high content visual Huang Chunhua cosmetic comprising:
the cosmetic comprises phase A, phase B and phase E; the weight portions are as follows:
the phase A comprises: dipotassium glycyrrhizinate: 0.05-0.25; allantoin: 0.05-0.25;
the phase B comprises: an oil phase component; optionally oil-dispersed encapsulated retinol; oil dispersion encapsulates retinol: 0.5-2.5;
the E phase comprises: SENS' FLOWER SD-SC:0-5;100：0-0.5；/>0-0.5, and SENS' FLOWER SD-SC,/L>100、/>At least one of the three is not zero; optionally water-soluble encapsulation of retinol; water-soluble encapsulation of retinol: 0.5-3;
when phase E includes water-soluble encapsulated retinol, phase B does not include oil dispersed encapsulated retinol; when the phase B contains oil-dispersed encapsulated retinol, the phase E does not contain water-soluble encapsulated retinol;
the preparation method comprises the following steps:
adding phase A into a water phase pot, heating to 70-90 ℃, and preserving heat;
adding phase B into oil phase pot, heating to 70-90deg.C, and keeping the temperature;
pumping the water phase into an emulsifying pot, pumping into an oil phase, and homogenizing;
cooling to 35-50deg.C, and adding phase E.
The features and capabilities of the present application are described in further detail below in connection with the examples.
A cosmetic with high content and view Huang Chunhua is provided, and the formula composition is shown in table 1:
TABLE 1
The preparation method comprises the following steps:
1. adding phase A in table 1 into water phase pot, stirring, heating to 70-90deg.C, and maintaining for 10-30min.
2. Adding phase B in Table 1 into oil phase pot, stirring, heating to 70-90deg.C, and maintaining for 10-30min.
3. Pumping the water phase into emulsifying pot, pumping into oil phase, stirring, homogenizing for 3-8min, adding phase C in table 1, and homogenizing for 1-3min.
4. Cooling to 60-70deg.C, adding phase D in table 1, cooling to 35-50deg.C, adding phase E and phase F in table 1, and stirring for 15min.
Patch test:
1. materials and methods
(1) Test article: example sample
(2) Negative control: no encapsulated retinol samples were added.
(3) The subject: 30 people
(4) The patch method comprises the following steps: placing 0.020-0.025ml of the test substance into a patch device, applying the low sensitization tape to the inner side of the arm of the subject, removing the test substance after 24 hours, and observing skin reaction after 0.5 hours, 24 hours and 48 hours respectively. The results were recorded according to the skin reaction grading standard in the skin reaction grading experiment of the seventh chapter of human body patch of the 2015 edition of the technical Specification for cosmetic safety.
2. Grading of adverse skin reactions
TABLE 2
The anti-sensitization formula is built up for the cosmetics in table 1 below, the preparation method is as described above, and the experimental test method is as described above.
Comparative example 1
An anti-allergy formula:
in phase A, dipotassium glycyrrhizinate 0.15%, allantoin 0.15%
In phase B, multisal Retinol is 1%
In 3.E phase, anallerg- -Retinol-10C 0%, SENS' FLOWER SD-SC0%,100 0％，/>0％
blank formula:
in phase A, dipotassium glycyrrhizinate 0.15%, allantoin 0.15%
In phase B, multisal Retinol is 0%
In 3.E phase, anallerg- -Retinol-10C 0%, SENS' FLOWER SD-SC0%,100 0％，/>0％
patch test data:
TABLE 3 Table 3
Comparative example 2
An anti-allergy formula:
in phase A, dipotassium glycyrrhizinate 0.15%, allantoin 0.15%
In phase B, multisal Retinol is 0%
In 3.E phase, anallerg- -Retinol-10C 1.1%, SENS' FLOWER SD-SC0%,100 0％，/>0％
blank formula:
in phase A, dipotassium glycyrrhizinate 0.15%, allantoin 0.15%
In phase B, multisal Retinol is 0%
In 3.E phase, anallerg- -Retinol-10C 0%, SENS' FLOWER SD-SC0%,100 0％，/>0％
patch test data:
example 1
An anti-allergy formula:
in phase A, dipotassium glycyrrhizinate 0.15%, allantoin 0.15%
In phase B, multisal Retinol is 1%
In 3.E phase, anallerg- -Retinol-10C 0%, SENS' FLOWER SD-SC 1%,100 0％，/>0％
blank formula:
in phase A, dipotassium glycyrrhizinate 0.15%, allantoin 0.15%
In phase B, multisal Retinol is 0%
In 3.E phase, anallerg- -Retinol-10C 0%, SENS' FLOWER SD-SC 1%,100 0％，/>0％
patch test data:
example 2
An anti-allergy formula:
in phase A, dipotassium glycyrrhizinate 0.15%, allantoin 0.15%
In phase B, multisal Retinol is 0%
In 3.E phase, anallerg- -Retinol-10C 1.1%, SENS' FLOWER SD-SC 1%,100 0％，/>0％
blank formula:
in phase A, dipotassium glycyrrhizinate 0.15%, allantoin 0.15%
In phase B, multisal Retinol is 0%
In 3.E phase, anallerg- -Retinol-10C 0%, SENS' FLOWER SD-SC 1%,100 0％，/>0％
patch test data:
example 3
An anti-allergy formula:
in phase A, dipotassium glycyrrhizinate 0.15%, allantoin 0.15%
In phase B, multisal Retinol is 2%
In 3.E phase, anallerg- -Retinol-10C 0%, SENS' FLOWER SD-SC 1%,100 0％，/>0％
blank formula:
in phase A, dipotassium glycyrrhizinate 0.15%, allantoin 0.15%
In phase B, multisal Retinol is 0%
In 3.E phase, anallerg- -Retinol-10C 0%, SENS' FLOWER SD-SC 1%,100 0％，/>0％
patch test data:
example 4
An anti-allergy formula:
in phase A, dipotassium glycyrrhizinate 0.15%, allantoin 0.15%
In phase B, multisal Retinol is 0%
In 3.E phase, anallerg- -Retinol-10C 2.3%, SENS' FLOWER SD-SC 1%,100 0％，/>0.2％
blank formula:
in phase A, dipotassium glycyrrhizinate 0.15%, allantoin 0.15%
In phase B, multisal Retinol is 0%
In 3.E phase, anallerg- -Retinol-10C 0%, SENS' FLOWER SD-SC 1%,100 0％，/>0.2％
patch test data:
example 5
An anti-allergy formula:
in phase A, dipotassium glycyrrhizinate 0.15%, allantoin 0.15%
In phase B, multisal Retinol is 2.5%
In 3.E phase, anallerg- -Retinol-10C 0%, SENS' FLOWER SD-SC 1%,100 0％，/>0％
blank formula:
in phase A, dipotassium glycyrrhizinate 0.15%, allantoin 0.15%
In phase B, multisal Retinol is 0%
In 3.E phase, anallerg- -Retinol-10C 0%, SENS' FLOWER SD-SC 1%,100 0％，/>0％
patch test data:
example 6
The formula comprises the following components:
in phase A, dipotassium glycyrrhizinate 0.2% and allantoin 0.2%
In phase B, multisal Retinol is 0%
In 3.E phase, anallerg- -Retinol-10C 3%, SENS' FLOWER SD-SC 2%,100 0％，/>0.2％
blank formula:
in phase A, dipotassium glycyrrhizinate 0.2% and allantoin 0.2%
In phase B, multisal Retinol is 0%
In 3.E phase, anallerg- -Retinol-10C 0%, SENS' FLOWER SD-SC 2%,100 0％，/>0.2％
patch test data:
example 7
An anti-allergy formula:
in phase A, dipotassium glycyrrhizinate 0.15%, allantoin 0.15%
In phase B, multisal Retinol is 2.5%
In 3.E phase, anallerg- -Retinol-10C 0%, SENS' FLOWER SD-SC 1%,100 0.3％，/>0％
blank formula:
in phase A, dipotassium glycyrrhizinate 0.15%, allantoin 0.15%
In phase B, multisal Retinol is 0%
In 3.E phase, anallerg- -Retinol-10C 0%, SENS' FLOWER SD-SC 1%,100 0.3％，/>0％
patch test data:
as can be seen from the comparison results of comparative examples 1 and 2, the conventional anti-allergic system cannot inhibit the irritation of retinol, and the analysis reasons are that dipotassium glycyrrhizinate and allantoin have a single matching target point because the action mechanisms of dipotassium glycyrrhizinate and allantoin are both used for inhibiting skin inflammation so as to inhibit allergy.
As is clear from the comparison between the results of example 1 and example 2, dipotassium glycyrrhizinate, allantoin and SENS 'FLOWER SD-SC can well inhibit the irritation of retinol, and the analysis is that SENS' FLOWER SD-SC can act against pain receptors (TRPV 1) in addition to the anti-inflammatory mechanism, thereby reducing our pain and itch feeling, and thus can well inhibit the irritation of retinol. However, it can be seen from example 2 that the water soluble encapsulated retinol is more irritating than the oil dispersed encapsulated retinol.
As can be seen from a comparison of examples 2, 4, 6, the addition ofFurther suppresses the feeling of pain and itching, and can well suppress the irritation of high-concentration water-soluble coated retinol.
As can be seen from examples 1,3 and 5, the combination of dipotassium glycyrrhizinate, allantoin and SENS' FLOWER SD-SC can meet the irritation of oil-dispersed coated retinol with low concentration to high concentration, and only the dosage of retinol with particularly high concentration is required to be compounded to a small extent100。
To sum up: anti-allergic systems that simply inhibit inflammation are generally not very resistant to retinol irritation, whereas licorice in the present applicationDipotassium acid, allantoin and SENS' FLOWER SD-SC anti-sensitization system can meet anti-sensitization requirements of retinol formulations and even high-content retinol formulations, if retinol is continuously added, the system can be added appropriately for cost consideration100 or->Thereby achieving better anti-allergic effect.
The above description is only of the preferred embodiments of the present application and is not intended to limit the present application, but various modifications and variations can be made to the present application by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application should be included in the protection scope of the present application.
Claims (2)
1.A high content visual Huang Chunhua cosmetic, comprising, in mass percent:
wherein, in the raw material with the serial number of 20, the retinol content is 10 weight percent;
the retinol content in the raw material with the serial number of 34 is 9.5 weight percent;
the content of the raw material SENS' FLOWER SD-SC with the number 29 is not 0;
wherein the SENS' FLOWER SD-SC comprises the following components: water, 1, 3-propanediol, crocus sativus flower extract;
the SymCalmin ® Comprises the following components: butanediol, 1, 2-pentanediol, hydroxyphenyl propionamide benzoic acid, ascorbyl palmitate;
the SymRelief ® 100 comprises the following components: bisabolol, ginger root extract;
when the content of the raw material with the number 20 is 0, the content of the raw material with the number 34 is not 0; or alternatively
When the content of the raw material with the number 20 is not 0, the content of the raw material with the number 34 is 0.
2. A process for preparing a cosmetic having a high content of Huang Chunhua as claimed in claim 1, characterized in that,
the preparation method comprises the following steps:
adding phase A into water phase pot, stirring, heating to 70-90deg.C, and maintaining for 10-30min;
adding phase B into oil phase pot, stirring, heating to 70-90deg.C, and maintaining for 10-30min;
pumping the water phase into an emulsifying pot, pumping into an oil phase, stirring, homogenizing for 3-8min, adding phase C, and homogenizing for 1-3min;
cooling to 60-70deg.C, adding phase D, cooling to 35-50deg.C, adding phase E and phase F, and stirring for 15min.
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| JP2022190755A JP2023169857A (en) | 2022-05-17 | 2022-11-29 | Anti-allergic composition with high retinol content, cosmetics with high retinol content, and production methods therefor |
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| CN101095651A (en) * | 2006-06-27 | 2008-01-02 | 日本乐敦制药株式会社 | External composition for skin |
| CN107468621A (en) * | 2017-09-27 | 2017-12-15 | 杭州梵琳科技有限公司 | Shu Min facial treatment milk and preparation method thereof |
| CN110403831A (en) * | 2019-07-26 | 2019-11-05 | 李和伟 | A kind of functionality antiallergic barrier ink-jet ink and its preparation method and application |
| CN112915043A (en) * | 2021-02-07 | 2021-06-08 | 深圳市护家科技有限公司 | Method for wrapping and stabilizing retinoid and application thereof |
| CN113616543A (en) * | 2021-09-14 | 2021-11-09 | 上海友仁生物科技有限公司 | Preparation method of wrapped retinol essence |
| CN113893193A (en) * | 2021-10-20 | 2022-01-07 | 广州市涵美化妆品有限公司 | Instant repair composition, essence and preparation method thereof |
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2022
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- 2022-11-29 JP JP2022190755A patent/JP2023169857A/en active Pending
Patent Citations (7)
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|---|---|---|---|---|
| CN1638725A (en) * | 2002-03-04 | 2005-07-13 | 宝洁公司 | Stable personal care compositions containing a retinoid |
| CN101095651A (en) * | 2006-06-27 | 2008-01-02 | 日本乐敦制药株式会社 | External composition for skin |
| CN107468621A (en) * | 2017-09-27 | 2017-12-15 | 杭州梵琳科技有限公司 | Shu Min facial treatment milk and preparation method thereof |
| CN110403831A (en) * | 2019-07-26 | 2019-11-05 | 李和伟 | A kind of functionality antiallergic barrier ink-jet ink and its preparation method and application |
| CN112915043A (en) * | 2021-02-07 | 2021-06-08 | 深圳市护家科技有限公司 | Method for wrapping and stabilizing retinoid and application thereof |
| CN113616543A (en) * | 2021-09-14 | 2021-11-09 | 上海友仁生物科技有限公司 | Preparation method of wrapped retinol essence |
| CN113893193A (en) * | 2021-10-20 | 2022-01-07 | 广州市涵美化妆品有限公司 | Instant repair composition, essence and preparation method thereof |
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