CN113615836A - Cathay hickory oil composition with function of reducing blood pressure and preparation method thereof - Google Patents
Cathay hickory oil composition with function of reducing blood pressure and preparation method thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of functional health food preparation, and particularly relates to a pecan oil composition with a function of reducing blood pressure and a preparation method thereof. The health-care tea uses the pecan oil, the eucommia bark extract, the ginkgo extract, the pseudo-ginseng extract and the soybean lecithin as main raw materials, has the function of reducing blood pressure by utilizing the comprehensive action of various components, and is non-toxic and harmless to human bodies. The invention has rich nutrition, no bitter taste and convenient taking, and conforms to the regulations of the national food sanitation law. The pecan oil composition can be used independently by patients with mild symptoms, can be used together with other antihypertensive drugs for treating severe diseases, can greatly reduce the use amount of common antihypertensive western medicines, has obvious treatment effect, and can remarkably slow down or eliminate other complications.
Description
Technical Field
The invention belongs to the technical field of functional health food preparation, and particularly relates to a pecan oil composition with a function of reducing blood pressure and a preparation method thereof.
Background
Hypertension is the most important risk factor for cardiovascular diseases, often causes complications of heart, brain, kidney and other organs, and seriously harms human health. In 2010, the number of hypertension patients in China has exceeded 2 billion, and continues to increase at 1 million per year. Moreover, hypertension is no longer a 'patent' for the middle-aged and elderly, and the prevalence rate of hypertension in people under 30 years old has reached 10%, with the rising trend being far higher than that of the elderly. Cardiovascular diseases become the first cause of death for residents in China, and statistics show that 50% of 300 million cardiovascular patients who die every year in China are related to hypertension. Therefore, the understanding of hypertension is improved, and the Chinese medicinal composition has extremely important significance for early prevention and timely treatment.
The modern medicine for treating hypertension generally comprises the following steps: dietotherapy, tea therapy, health care, traditional Chinese medicine and finally western medicines. In order to control blood pressure, various methods other than taking medicines have been proposed. In dietetic china, it is common practice to prevent or ameliorate certain diseases through the use of food intake. The pecan oil is extracted from fruits of wild woody plants of the oil family, and is one of four woody plant oils in the world. The dual functions of food therapy of Chinese hickory oil are actually superior to olive oil, and besides the fatty acid compositions, the grease characteristics and the nutritional ingredients of the two types of grease are similar, the tea oil also contains tea polyphenol and camelliaside (tea saponin, or called tea saponin) which are specific physiological active substances and are not contained in the olive oil. The content of monounsaturated fatty acid exceeds that of olive oil and reaches 80 percent; tea oil is rich in vitamin E, twice as high as olive oil. Tea oil is collected and carried as medicinal oil in the Chinese pharmacopoeia (1995 edition), and has good effect for oral administration and external application because the tea oil is rich in various nutritional ingredients. It can be taken frequently to inhibit aging, and has good effects in preventing chronic pharyngitis and hypertension, arteriosclerosis, and cardiovascular system diseases.
The phytosterol is a natural active substance which can effectively reduce cholesterol, can inhibit the absorption of human body to cholesterol, and has the functions of reducing cholesterol and preventing cardiovascular diseases. The human body can not synthesize the phytosterol and must obtain the phytosterol from the diet, and the edible oil is an important channel for people to take the phytosterol from the diet. Since the pecan oil has low content of phytosterol and has no obvious effect on reducing cholesterol, Chinese patent application (CN101869152A) discloses a preparation method of refined health-care pecan oil with the phytosterol and the pecan oil compatible, although the method can lead the total content of the sterol in the pecan oil to be 10000-15000 mg/L. However, the health care product prepared by adopting the single pecan oil does not have obvious effect of reducing the blood pressure, so that the composition which takes the pecan oil as the main component and has better function of reducing the blood pressure is necessary.
Disclosure of Invention
The invention aims to solve the problems in the prior art and provides a pecan oil composition which takes natural botanical drugs as raw materials and has the function of reducing blood pressure and a simple preparation method.
The purpose of the invention can be realized by the following technical scheme:
the pecan oil composition with the function of reducing blood pressure comprises the following raw materials in parts by weight: 50-95 parts of hickory oil, 1-10 parts of eucommia ulmoides extract, 2-20 parts of ginkgo extract, 1-10 parts of pseudo-ginseng extract, 2-8 parts of soybean lecithin and 0.5-3 parts of auxiliary material.
In the pecan oil composition with the function of reducing blood pressure, the auxiliary materials are mixed according to a mass ratio of 1: (0.5-2) sucrose fatty acid ester and vitamin E mixture.
The invention develops a pecan oil composition with the function of reducing blood pressure by taking natural plant medicines as raw materials and simple preparation method based on the functions of preventing cardiovascular diseases and improving myocardial functions of pecan oil and matching with various functions of tonifying liver and kidney, strengthening bones and muscles, reducing blood pressure and the like of eucommia ulmoides, wherein the adopted eucommia ulmoides extract is obtained by chemically extracting dried bark of eucommia ulmoides in the family of eucommia ulmoides, and the ginkgo extract is used for assisting in treating symptoms such as coronary heart disease, angina pectoris, chest distress, shortness of breath and the like, and the pseudo-ginseng extract has obvious blood fat regulating effect and immunoregulation effect, has obvious compound synergism and has good blood pressure reducing effect.
In the pecan oil composition with the function of reducing blood pressure, the pecan oil contains phytosterol with the content of not less than 10000mg/L and unsaturated fatty acid with the content of not less than 80%.
In the pecan oil composition with the function of reducing blood pressure, the total flavone of the ginkgo extract is not less than 15 percent, and the lactone is not less than 3 percent.
In the pecan oil composition with the function of reducing blood pressure, the total saponins of the panax notoginseng extract accounts for 10-80 percent.
The invention also provides a preparation method of the pecan oil composition with the function of reducing blood pressure, which comprises the following steps:
s1, drying the hickory oil seeds, removing shells, crushing, moistening, steaming, frying, squeezing to obtain a crude hickory oil product, refining to obtain edible hickory oil, and adding phytosterol to obtain the hickory oil;
s2, preparing raw materials;
s3, homogenizing and mixing the hickory oil, the eucommia ulmoides extract, the ginkgo extract, the pseudo-ginseng extract, the soybean lecithin and auxiliary materials to obtain a thick mixture;
s4, pressing the thick mixture to obtain the pecan oil composition.
Preferably, in step S1, fresh pecan oil seeds are dried, the pecan oil seeds are shelled, then the pecan oil seeds are processed into powder by a pulverizer, the powder is wet by steam or water spray and then is subjected to wet steaming and frying, a tea oil crude product is obtained by squeezing by a screw press, then the tea oil crude product is subjected to a refining process to obtain edible tea oil, and the tea oil is added with phytosterol until the sterol content in the tea oil is detected to be higher than 10000mg/L, so that the pecan oil is obtained.
Preferably, the refining step includes deacidification, washing with water, and purification of a smell.
In the preparation method of the pecan oil composition with the function of reducing blood pressure, the water content of the dried pecan oil seeds in the step S1 is 5-6%.
In the preparation method of the pecan oil composition with the function of reducing blood pressure, the steaming and frying temperature of the step S1 is 130-.
In the preparation method of the pecan oil composition with the function of reducing blood pressure, the temperature of the homogenized material in the step S3 is 30-70 ℃, and the pressure is 15-25 Mpa. The invention carries out homogeneous mixing at 30-70 ℃, is beneficial to mixing all the components, has not very high temperature and can also ensure the chemical stability of all the components. Under 15-25MPa, the raw material is easy to be homogenized quickly, so that all components of the raw material are formed into a uniform and single-phase mixture from a dispersed and non-uniform multi-phase mixture, and the average particle size of the raw material is reduced after the raw material is homogenized under high pressure, so that the stability, the absorptivity and the functionality of the raw material are greatly improved.
In the above preparation method of the pecan oil composition having the function of lowering blood pressure, the pecan oil composition prepared by the pressing method of step S4 is a capsule.
Preferably, the method for preparing the capsule by the compression method comprises the following steps:
firstly, according to the formula of a capsule wall material, putting gelatin into distilled water for soaking to swell, adding other materials together after the gelatin is dissolved, and stirring and mixing uniformly;
secondly, taking out the prepared capsule wall glue solution, coating the capsule wall glue solution on the surface of a flat plate to ensure that the thickness is uniform, and then heating the capsule wall glue solution at the temperature of about 90 ℃ to evaporate the water on the surface to form a soft film with certain toughness and certain elasticity;
thirdly, pressing the soft capsules; when in small-batch production, the mixture is manually pressed by a pill pressing die; in mass production, an automatic rotary bag rolling machine is often adopted for production.
Compared with the prior art, the invention has the following beneficial effects:
1. the invention selects natural plant medicines as raw materials, utilizes the comprehensive effect of various components to ensure that the traditional Chinese medicine composition has the function of reducing blood pressure and is non-toxic and harmless to human bodies.
2. The invention has rich nutrition, no bitter taste and convenient taking, and conforms to the regulations of the national food sanitation law.
3. The pecan oil composition can be used independently by patients with mild symptoms, can be used together with other antihypertensive drugs for treating severe diseases, can greatly reduce the use amount of common antihypertensive western medicines, has obvious treatment effect, and can remarkably slow down or eliminate other complications.
Detailed Description
The following are specific examples of the present invention and further describe the technical solutions of the present invention, but the present invention is not limited to these examples.
Examples 1 to 4:
s1, drying fresh pecan oil seeds, controlling the water content to be 5-6%, shelling, crushing, moistening, steaming and frying at 135 ℃, controlling the water content to be 3-4%, squeezing to obtain a pecan oil crude product, deacidifying, washing with water, and deodorizing to obtain edible pecan oil, detecting the content of unsaturated fatty acids in the tea oil to be not less than 80%, and the content of sterols to be not less than 1000mg/L, adding phytosterol, and stirring uniformly until the content of sterols in the tea oil to be higher than 10000mg/L to obtain the pecan oil;
s2, preparing raw materials according to the table 1;
s3, homogenizing and mixing hickory oil, eucommia ulmoides extracts, ginkgo extracts, pseudo-ginseng extracts, soybean lecithin and auxiliary materials at 50 ℃ and 20MPa to obtain a thick mixture;
s4, pressing the thick mixture to obtain the pecan oil composition.
Application example 1:
10 male SHR rats of 10 weeks old were bred for 20 days, and then the blood pressure basic value and body weight were measured to prepare the compound hickory oil of example 1 at a dose of 0.5 g/kg-1The low dose was administered continuously for 4 weeks, and at 1, 2, 3, 4 weeks, each group of rats was weighed and then measured for Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Blood Pressure (MBP), and Heart Rate (HR).
Application example 2:
10 male SHR rats of 10 weeks old were bred for 20 days, and the blood pressure and body weight were measured to obtain compound hickory oil of example 1 at a dose of 1.0 g/kg-1The medium dose was administered continuously for 4 weeks. At 1, 2, 3, 4 weeks of administration, each group of rats was weighed and then measured for Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Blood Pressure (MBP) and Heart Rate (HR).
Application example 3:
10 male SHR rats of 10 weeks old were bred for 20 days, and the blood pressure and body weight were measured to obtain compound hickory oil of example 1 at a dose of 2.0 g/kg-1High doses were administered continuously for 4 weeks. At 1, 2, 3, 4 weeks of administration, each group of rats was weighed and then measured for Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Blood Pressure (MBP) and Heart Rate (HR).
Application comparative example 1:
the preparation method of the 2 percent sucrose fatty ester solution comprises the following steps: 20g of sucrose fatty acid ester (Mitsubishi corporation, 0Z10940A) was added to 1000ml of 98 ℃ distilled water, and the mixture was stirred and homogenized by a homogenizer, cooled, and stored at 4 ℃.
10 male SHR rats of 10 weeks old were bred for 20 days, and then a 2% sucrose fatty ester solution (10 mL. kg.) was prepared by measuring the blood pressure basal value and body weight-1) Administration was continued for 4 weeks. At 1, 2, 3, 4 weeks of administration, each group of rats was weighed and then measured for Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Blood Pressure (MBP) and Heart Rate (HR).
Application comparative example 2:
the preparation method of the 2 percent sucrose fatty ester solution comprises the following steps: 20g of sucrose fatty acid ester (Mitsubishi corporation, 0Z10940A) was added to 1000ml of 98 ℃ distilled water, and the mixture was stirred and homogenized by a homogenizer, cooled, and stored at 4 ℃.
10 male Wistar rats aged 10 weeks were bred for 20 days, and then the blood pressure basal value and body weight were measured to prepare a 2% sucrose fatty ester solution (10 mL. kg.)-1) Administration was continued for 4 weeks. At 1, 2, 3, 4 weeks of administration, each group of rats was weighed and then measured for Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Blood Pressure (MBP) and Heart Rate (HR).
Data processing: statistical analysis was performed using SPSS13.0 software, with the remaining data being averaged. + -. standard deviationThe test results are shown, evaluated by the application of t-test to the metrology data.
Table 1: EXAMPLES 1-4 blending ratio of raw materials of Carya cathayensis oil composition
Table 2: using examples 1-3, using comparative examples 1-2 rats varied in body weight over different dosing periods (g, n-10,)
table 3: using examples 1-3, using comparative examples 1-2 rats the Systolic Blood Pressure (SBP) was varied at different dosing periods (mmHg, n-10,)
table 4: using examples 1-3, using comparative examples 1-2, the variation of diastolic pressure (DBP) in rats at different dosing stages (mmHg, n-10,)
table 5: use examples 1-3, use comparative examples 1-2 averaging of rats at different dosing stagesVariation in pressure (MBP) (mmHg, n10,)
table 6: using example 1, using comparative examples 1-2 rats varied in Heart Rate (HR) over different dosing periods (bpm, n-10,)
as can be seen from table 2, the weight before administration of SHR rats of the application comparative example 1 was significantly higher than that of the application comparative example 2, and the weight of the rats of the application comparative example 1 was significantly lower than that of the rats of the application comparative example 2 from the beginning of 3 weeks of administration; compared with application comparative example 1, 0.5, 1.0, 2.0 g.kg were given-1After 4 weeks, the weight average of rats in the administration group was not significantly changed in the rats of examples 1 to 3.
As can be seen from Table 3, compared with the application comparative example 2, the SHR rat using the application comparative example 1 has significantly higher systolic pressure before and after administration than the rat using the application comparative example 2; compared with application comparative example 1, 0.5, 1.0, 2.0 g.kg were given-14 weeks later, high dose group (2.0 g.kg) of rats treated with compound hickory oil-1) The systolic pressure of rats is remarkably reduced at 2, 3 and 4 weeks of administration, and the medium dose group (1.0 g.kg)-1) The rats showed significant reduction in systolic blood pressure at 2 and 4 weeks of administration, and the low dose group (0.5 g.kg)-1) The systolic blood pressure was significantly reduced in rats at 2 weeks of administration.
As can be seen from Table 4, in comparison with comparative example 2, which is applied, it should be noted thatThe post-and pre-administration diastolic pressures of the SHR rats of comparative example 1 were significantly higher than the systolic pressure of the SHR rats of comparative example 2; compared with application comparative example 1, 0.5, 1.0, 2.0 g.kg were given-14 weeks later, high dose group (2.0 g.kg) of rats treated with compound hickory oil-1) The diastolic pressure of rats was significantly reduced at 2, 3 and 4 weeks after administration, and the medium dose group (1.0 g. kg)-1) The diastolic pressure of the rats is obviously reduced at 2 and 4 weeks of administration, and the low dose group (0.5 g.kg)-1) The diastolic pressure was significantly reduced in rats at 2 weeks of administration.
As can be seen from Table 5, compared with the use of comparative example 2, the average pressure before and after administration of the SHR rat using comparative example 1 was significantly higher than the systolic pressure of the rat using comparative example 2; compared with application comparative example 1, 0.5, 1.0, 2.0 g.kg were given-14 weeks later, high dose group (2.0 g.kg) of rats treated with compound hickory oil-1) The average pressure of rats is remarkably reduced at 2, 3 and 4 weeks of administration, and the medium dose group (1.0 g.kg)-1) The average pressure of rats is obviously reduced at 2 and 4 weeks of administration, and the low dose group (0.5 g.kg)-1) The mean pressure in rats was significantly reduced at 2 weeks of administration.
As can be seen from Table 6, compared with the application comparative example 2, the heart rate before and after administration of the SHR rat using the application comparative example 1 is significantly higher than the systolic pressure of the rat using the application comparative example 2; compared with application comparative example 1, 0.5, 1.0, 2.0 g.kg were given-1After 4 weeks, the heart rate times of rats of each administration group have no obvious change.
The above results preliminarily show that the blood pressure of the SHR rats using comparative example 1 is significantly higher than that of the normal Wistar rats and increases with the increase of the week age; the compound hickory oil can obviously inhibit the increase of the blood pressure of SHR rats, and the action way of the compound hickory oil is probably to inhibit the increase of the blood pressure by softening blood vessels. The compound hickory oil of the invention can inhibit the blood pressure rise of SHR rats.
The technical scope of the invention claimed by the embodiments of the present application is not exhaustive, and new technical solutions formed by equivalent replacement of single or multiple technical features in the technical solutions of the embodiments are also within the scope of the invention claimed by the present application; in all the embodiments of the present invention, which are listed or not listed, each parameter in the same embodiment only represents an example (i.e., a feasible embodiment) of the technical solution, and there is no strict matching and limiting relationship between the parameters, wherein the parameters may be replaced with each other without departing from the axiom and the requirements of the present invention, unless otherwise specified. The technical means disclosed by the scheme of the invention are not limited to the technical means disclosed by the technical means, and the technical scheme also comprises the technical scheme formed by any combination of the technical characteristics. While the foregoing is directed to embodiments of the present invention, it will be appreciated by those skilled in the art that various changes may be made in the embodiments without departing from the principles of the invention, and that such changes and modifications are intended to be included within the scope of the invention.
The specific embodiments described herein are merely illustrative of the spirit of the invention. Various modifications or additions may be made to the described embodiments or alternatives may be employed by those skilled in the art without departing from the spirit or ambit of the invention as defined in the appended claims.
Claims (10)
1. The pecan oil composition with the function of reducing blood pressure is characterized by comprising the following raw materials in parts by weight: 50-95 parts of hickory oil, 1-10 parts of eucommia ulmoides extract, 2-20 parts of ginkgo extract, 1-10 parts of pseudo-ginseng extract, 2-8 parts of soybean lecithin and 0.5-3 parts of auxiliary material.
2. The pecan oil composition with the function of reducing blood pressure as claimed in claim 1, wherein the auxiliary materials comprise, by mass, 1: (0.5-2) sucrose fatty acid ester and vitamin E mixture.
3. The pecan oil composition having the function of lowering blood pressure as claimed in claim 1, wherein the pecan oil contains phytosterol in an amount of not less than 10000mg/L and unsaturated fatty acid in an amount of not less than 80%.
4. The pecan oil composition with the function of reducing blood pressure as claimed in claim 1, wherein the ginkgo biloba extract total flavonoids is not less than 15% and the lactones are not less than 3%.
5. The pecan oil composition with the function of reducing blood pressure as claimed in claim 1, wherein the total saponins of panax notoginseng extract is 10-80%.
6. A method for preparing the pecan oil composition with the function of reducing blood pressure according to claim 1, which comprises the following steps:
s1, drying the hickory oil seeds, removing shells, crushing, moistening, steaming, frying, squeezing to obtain a crude hickory oil product, refining to obtain edible hickory oil, and adding phytosterol to obtain the hickory oil;
s2, preparing raw materials;
s3, homogenizing and mixing the hickory oil, the eucommia ulmoides extract, the ginkgo extract, the pseudo-ginseng extract, the soybean lecithin and auxiliary materials to obtain a thick mixture;
s4, pressing the thick mixture to obtain the pecan oil composition.
7. The method for preparing the pecan oil composition with the function of reducing blood pressure as claimed in claim 6, wherein the water content of the pecan oil seeds dried in the step S1 is 5% -6%.
8. The method as claimed in claim 6, wherein the temperature of the step S1 is 130-140 ℃, and the water content of the walnut oil seeds after the step S1 is 3-4%.
9. The method for preparing the pecan oil composition with the function of reducing blood pressure according to claim 6, wherein the temperature of the homogenized material in the step S3 is 30-70 ℃, and the pressure is 15-25 MPa.
10. The method for preparing the pecan oil composition with the function of reducing blood pressure as claimed in claim 6, wherein the pecan oil composition prepared by the pressing method of step S4 is in the form of capsule.
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102318829A (en) * | 2011-08-17 | 2012-01-18 | 中国林业科学研究院亚热带林业研究所 | Compound camellia oil health product with function of blood pressure decreasing, and preparation method thereof |
CN103392834A (en) * | 2013-08-14 | 2013-11-20 | 山东三星玉米产业科技有限公司 | Nutrition blend oil applicable to middle aged and elderly people and preparation method thereof |
CN103845396A (en) * | 2014-03-05 | 2014-06-11 | 浙江大学 | Hickory sterol extractive and preparation method and application thereof |
CN105176666A (en) * | 2015-10-13 | 2015-12-23 | 汉中福来特野生核桃油有限公司 | Production process of wild pecan oil |
-
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- 2021-06-24 CN CN202110705572.XA patent/CN113615836A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102318829A (en) * | 2011-08-17 | 2012-01-18 | 中国林业科学研究院亚热带林业研究所 | Compound camellia oil health product with function of blood pressure decreasing, and preparation method thereof |
CN103392834A (en) * | 2013-08-14 | 2013-11-20 | 山东三星玉米产业科技有限公司 | Nutrition blend oil applicable to middle aged and elderly people and preparation method thereof |
CN103845396A (en) * | 2014-03-05 | 2014-06-11 | 浙江大学 | Hickory sterol extractive and preparation method and application thereof |
CN105176666A (en) * | 2015-10-13 | 2015-12-23 | 汉中福来特野生核桃油有限公司 | Production process of wild pecan oil |
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Application publication date: 20211109 |