KR100419121B1 - A functional food Containing herbes composition for female menopausal disorder - Google Patents

Abstract

The present invention relates to a food having an improved function of female menopausal symptoms, and more particularly, the herbal composition comprising bamboo leaf, Angelica, Cheongung, Baekjak, Baekchul, Baekboknyeong, Red ginseng and soybean extract as main components is 17β-estra. By increasing the diol and adding the herbal composition to various palatable foods to produce a functional food having a function of improving female menopausal symptoms, there is an excellent effect on the improvement of female menopausal symptoms, there is no fear of drug abuse or side effects, doctors The present invention relates to a food having a function of improving women's menopausal symptoms that can relieve discomfort of menopausal women without prescription.

Description

A functional food containing herb composition for female menopausal disorder

The present invention relates to a food additive and a functional food containing the food additive having a function of improving the menopausal symptoms, and more specifically, bamboo leaf, Angelica, Cheongung, Baekjak, Baekchul, Baekbokyeong, red ginseng and soybean extract as main components. And it relates to a food additive and a functional food containing the food additive having a function to improve the menopausal symptoms of women.

Menopausal (climacteric) is a type of endocrine syndrome that refers to a transition period in which the gradual decline in ovarian function occurs and the physiological and sexual function decreases or disappears. (menopause) comes. During menopause, acute symptoms may occur due to hormonal changes such as decreased estrogen production, elevated follicular stimulating hormone (FSH) and luteininzing hormone (LH). In other words, early symptoms may include vasomotor symptom such as hot flush and night sweat, and psychological symptom such as anxiety, loss of concentration, and depression. The urogenital and epidermal symptoms that appear may be osteoporosis, cardiovascular and cerebrovascular diseases, and many years after menopause.

Hormone replacement therapy, treatment with nonsteroidal agents, and the like have been developed as treatments to improve menopausal symptoms in women, and among them, hormone replacement therapy is known as the most effective method. However, long-term use of the drug in accordance with the above therapy may cause endometrial cancer, breast cancer, hypertension, thrombosis, biliary tract stones, menstrual bleeding, and side effects such as ovarian overstimulation. There is a problem that can not be taken without prescription.

In order to overcome the problems caused by the therapy of these drugs, the development of women's menopausal symptoms improver, which is composed mainly of natural herbal medicine, has been tried, among which red ginseng is known to be useful for improving various menopausal symptoms. Korean Ginseng. 1990; 20p-24p)

In addition, Dangwi Paksan is known to be effective in women's menopausal symptoms, such as herbal medicines, which have been traditionally known as herbal medicine books. (The Ginseng Review. 1991; vol 18: 95p-97p).

In addition, Korean Patent Publication No. 2003-0023297 discloses a composition for improving menopausal syndrome containing soybean extract and red ginseng extract containing isoflavin, in particular, some of the present inventors red ginseng, isoflavones, Angelica peony Red ginseng complex products prepared with acid as the main ingredient have been suggested to be the most effective in patients with menopausal syndrome. (Korean Society for Menopause, Vol. 8 No. 1, 2002. 3. p46-p58)

On the other hand, the prior art based on the herbal medicine can reduce side effects than the therapy with drugs, but the medicinal effect to improve the menopausal symptoms of women is insignificant. Development of functional foods based on medicinal herbs such as red ginseng, Dangwijak Paksan or Isoflavones, which are known to be effective for the female menopausal symptoms so as to effectively improve female menopausal symptoms without fear of drug addiction or side effects while preventing imbalance. This is being tried.

By the way, Dangwi Paksan is known as an effective herbal composition for the female menopausal symptoms is a herbal composition consisting of medicinal herbs such as tangwik, Cheonggung, Baekjak, Baekbyeong and Baekbokryeong, or herbal medicines are published by the Korean Food Industry Association. Because it is not a herbal medicine that can be used as a food ingredient listed in, it can not be used as a food raw material, except that the tangwikjaksan composition except for taxa effect on women's menopausal symptoms, functional foods based on the tangwikjaksan acid composition is limited to development Only the Republic of Korea Patent Publication No. 2003-0033473 removes the tackiness that is too weak in the composition of Dongguk Paksan and extract the mixed extract of Baekjak, Danggui, safflower seed, Cheongung, Baekchul, Hwanggi, Bokryeong, deodeok, corn beard, Yulmu, health Only compositions for improving gynecological diseases are proposed as active ingredients.

Therefore, the present inventors have not only facilitated the development of functional foods but also improved the symptoms of female menopausal symptoms in Dongguk Paksan when the herbal medicines contained in Dongguk Paksan were replaced with the herbal medicine bamboo leaves that were used as food ingredients. The present invention was completed by confirming that it is effective through animal experiments.

Accordingly, an object of the present invention is to provide a functional food that replaces taxa with herbal medicines registered in the food industry and at the same time has a function to improve women's menopausal symptoms in order to apply the Dongguk Paksan to food.

It is another object of the present invention to provide a functional food additive that has a herbal extract composed of bamboo leaf, Angelica, Cheonggung, Baekjak, Baekchul, Baekbokryeong and Red Ginseng, and soybeans to improve female menopausal symptoms.

In addition, an object of the present invention is to provide a variety of functional foods containing herbal extracts composed of bamboo leaf, Angelica, Cheongung, Baekjak, Baekbyeong, Baekbokryeong and red ginseng and soybeans to show the improvement function of female menopausal symptoms.

In order to achieve the above object, the present invention provides a food additive to improve the female menopausal symptoms of the herbal extract consisting of bamboo leaf, Angelica, Cheongung, Baekjak, Baekchul and Baekbokryeong.

In another aspect, the present invention provides a food additive having an improvement function of female menopausal symptoms further comprising red ginseng and soybean extract in the bamboo leaf, Angelica, Cheongung, Baekjak, Baekchul, Baekbokryeong.

In addition, an object of the present invention is to provide a variety of functional foods containing a herbal extract consisting of bamboo leaf, Angelica, Cheongung, Baekjak, Baekchul, Baekbokryeong and red ginseng and soybean having an improvement of female menopausal symptoms.

Referring to the present invention in more detail as follows.

According to the present invention, the herbal medicine taxa contained in Dangguijak Paksan is used as a food raw material, so it is a herbal composition that replaces the Taxa with bamboo leaves so that the Takgui Paksan composition can be applied to foods. It is confirmed that the herbal composition consisting of a significant increase in the level of estradiol, a female hormone, and new functional food material is expected to improve the menopausal symptoms.

The present invention is characterized in that bamboo leaf, Angelica, Cheongung, Baekjak, Baekchul and Baekbokryeong are extracted by hot water, and the herbal extract prepared by spray-drying the herbal extract is added to food. In another aspect, the present invention can be added to the herbal medicine extract containing red ginseng and soybean in the herbal composition.

The method of preparing the herbal composition of the present invention is as follows.

The present invention is mixed with bamboo leaf, Angelica, Cheonggung, Baekjak, Baekchul and Baekbokryeong, and after adding purified water, hot water is extracted twice at 80 ° C. for 4 hours, concentrated with a reduced pressure concentrator, and spray-dried to dry the powder of the herbal extract. Get

The present invention can be obtained by further mixing and extracting red ginseng and soybean in the herbal composition to obtain a powder of the herbal extract.

In addition, the present invention can be prepared by mixing the bamboo leaf, Angelica, Cheonggung, Baekjak, Baekchul, Baekbokryeong and red ginseng by extracting, concentrating and spray drying together.

Although it is preferable that the compounding ratio of each component in the herbal composition which concerns on this invention is set variously according to their kind, For example, the following compounding ratios are preferable.

Preferred weight ratios of Angelica, Cheongung, Baekjak, Baekchul, and Baekbokryeong in the herbal composition of the present invention are 1: 0.5 to 1.5: 0.5 to 1.5: 1 to 2.5: 1 to 2: 1 to 2, more preferably 1 : 0.75 to 1.2: 0.75 to 1.2: 1 to 2.5: 1 to 1.5: 1 to 1.5, and most preferably 1: 0.75: 0.75: 1: 1: 1.

In the present invention, the weight ratio of red ginseng and soybean further contained in the composition is preferably 1: 1 to 3: 0.2 to 1, more preferably 1: 1 to 2.5: 0.3 to 0.8, and most preferably the weight ratio of bamboo leaves. Is 1: 1: 0.3. In addition, the soy extract preferably contains 25% by weight or more of isoflavones, and more preferably soy extract containing 30% by weight or more of isoflavones. The soybean extract used in the present invention was manufactured by Samzo Celltech Co., Ltd., and a soybean extract (Yuzenflavone ^? ) Containing 30% by weight of isoflavone was used.

In addition, the present invention can be prepared by the conventionally known method by adding the herbal extracts obtained in the conventional palatable food, and can be formulated in a general formulation, and other ingredients in addition to the above components, that is, fermentation Calcium lactate, vitamin D ₃ , wheat germ oil, soybean oil, white lead, α-tocopherol and the like can be appropriately selected and blended by those skilled in the art depending on the formulation.

In particular, the present invention can produce functional foods containing herbal extracts that are expected to improve menopausal symptoms up to a wide range of menopausal or postmenopausal women.

The herbal extract of the present invention is suitable for use in addition to foods as a result of the acute toxicity test.

In the present invention, the effective amount of the herbal extract expected to improve menopausal symptoms is 0.5g to 4.0g per day for adults (60kg body weight), preferably 1.5g to 3.0g per day, added to various palates The herbal extract of the present invention is suitable 5 to 45% by weight of the total weight, preferably 20 to 35% by weight of the total weight.

Hereinafter, the present invention will be described in detail by production examples and experimental examples.

Preparation Example 1 Preparation of Bamboo Leaf, Angelica, Cheongung, Baekjak, Baekchul and Baekbokryung Mixed Herbal Powders

Bamboo leaf 1000g, Angelica 750g, Cheonggung 750g, Baekjak 1000g, Baekchul 1000g, Baekbokryeong 1000g was mixed and once, 10 times the total weight of the herbal composition, 5 times added purified water and extracted twice at 80 ℃ for 4 hours. The combined extraction and cooling of the extracts once and twice were concentrated under reduced pressure at 60 ° C. for 20 minutes at 5,000 rpm, and the extract was concentrated under reduced pressure at 60 ° C. to prepare an extract of 40% water, dissolved in water at 30 ° Bx, and then spray dried. Was put in. At this time, spray drying the spray dryer so that the internal temperature is 185 ℃, the external temperature is 95 ℃, and selects the powder that passes 95% or more. Prepared.

<Comparative Example 1> Preparation of Angelica peony extract

Angelica 750g, Cheonggung 750g, Baekjak 1000g, Baekchul 1000g, Baekbokryeong 1000g, and Taxa 1000g were prepared in the same manner as in Preparation Example 1 to prepare Dongguk Paksan powder.

Experimental Example 1 Measurement and Comparison of 17β-estradiol Concentrations in Blood by Bamboo Leaf, Angelica, Cheongung, Baekjak, Baekchul and Baekbokryung Mixed Herbal Powders

Sprague Dawley female rats of 21 days of age were prepared in each group of 5 (average body weight 50g) and 5-6 months old rats in each group of 5 (average body weight 350g) was also prepared by the powder prepared according to Preparation Example 1 and Comparative Example 1 Powder prepared according to the oral administration was 30mg / kg body wt / day or 3 days. The concentration of 17β-estradiol in blood before and 3 days after the administration of the sample was measured, and the average value of the measurement results is shown in Table 1 below.

TABLE 1

sample 21-day-old mouse 6 month old mouse Pre dose (pg / ml) After administration (pg / ml) Pre dose (pg / ml) After administration (pg / ml) Comparative Example 1 5.20 ± 0.35 6.70 ± 0.69 6.51 ± 0.74 7.65 ± 0.55 Preparation Example 1 5.22 ± 0.31 6.74 ± 0.57 6.58 ± 0.81 7.74 ± 0.70

As a result of Table 1, Preparation Example 1, in which the sample containing the extract powder of bamboo leaf, Angelica, Cheongung, Baekjak, Baekchul and Baekbokryeong mixed herbal medicines, was used in Comparative Example 1 in which the sample containing the extract of Angelica sacrum was young. The levels of 17β-estradiol in the blood increased almost equal to or higher in both rats and aged rats.

Therefore, the extract powder of bamboo leaf, tangui, Cheonggung, Baekjak, Baekchul and Baekbokryeong mixed herbal medicines have a significant increase in female hormones equivalent to that of Dangguijak Paksan, so the herbal composition is effective in improving menopausal symptoms, and replaces Donggukakaksan. It can be seen that it can be developed as a food additive or functional food.

Preparation Example 2 Preparation of Bamboo Leaf, Angelica, Cheongung, Baekjak, Baekchul, Baekbokryeong, Red Ginseng, Soybean Mixed Herbal Powder

Bamboo ginseng 1000g, Angelica 750g, Cheongung 750g, Baekjakok 1000g, Baekchul 1000g, Baekbokyeong 1000g, Red ginseng were ground and mixed into powder, respectively, to prepare an extract with a water content of 40% as in Preparation Example 1, and then 30 ° Bx with water. After dissolving in a spray dried to prepare a powder. Then, after the mixture of (a Yuzen ^flavone? Product manufactured by Corporation three trillion seltek) 200g isoflavones to the powder a soybean extract containing 30% by weight, and the proportion of the powder passed through a 100mesh selected such that at least 95% jukyeop, Angelica , Cheonggung, Baekjak, Baekchul, Baekbokyeong, Red ginseng, soybean mixed herbal powder was prepared.

Comparative Example 2 Preparation of Red Ginseng and Soybean Mixture Powder

It was prepared as a red ginseng 1000g, (a Yuzen ^flavone? Manufacturing Co., Ltd. from the three trillion seltek) a soy isoflavone extract containing 30% by weight of 200g and Preparation Example 2 was prepared in the red ginseng, soybean mixed powder.

<Comparative Example 3> Preparation of powdered Angelica, Cheonggung, Baekjak, Baekchul, Baekbokryeong, Red Ginseng, and Soybean Mixed Herb Powder except Taxa

Angelica 750g, horoscope 750g, decursiva 1000g, baekchul 1000g, baekbokryeong 1000g, ginseng 1000g, (a Yuzen ^isoflavones? Product manufactured Ltd. three trillion seltek) Angelica, Cnidium like 200g and Preparation 2 of isoflavones a soybean extract containing 30 wt% , Baekjak, Baekchul, Baekbokyeong, red ginseng, soybean mixed herbal powder was prepared.

<Comparative Example 4> Preparation of Taeksa, Danggui, Cheongung, Baekjak, Baekchul, Baekbokryeong, Red Ginseng, Soybean Mixed Herbal Powder

200g of Taxa 1000g, Angelica 750g, Cheongung 750g, Baekjakok 1000g, Baekchul 1000g, Baekbokyeong 1000g, Red ginseng 1000g, 200g soybean extract containing 30% by weight of isoflavones (Yuzen Flavon ^? Manufactured by Samzo Celltech Co., Ltd.) as in Preparation Example 2 Taxa, Angelica, Cheonggung, Baekjak, Baekchul, Baekbokyeong, Red ginseng, soybean mixed herbal powder was prepared.

Experimental Example 2 Measurement and Comparison of 17β-estradiol Concentrations in Blood by Bamboo Leaf, Angelica, Cheongung, Earl, Extract, Baekbokryeong, Red Ginseng, Soybean Mixed Herbal Powder and Red Ginseng, Soybean Mixed Herbal Powder

Sprague Dawley female rats of 21 days of age were prepared in each group of 5 (average weight 50g) and 5-6 months old rats of each group of 5 (average weight 350g) was prepared and prepared according to Preparation Example 2 and Comparative Example 2 Powder prepared according to 30mg / kg body wt / day was administered orally for 3 days. The concentration of 17β-estradiol in blood before and 3 days after the administration of the sample was measured, and the average value of the measurement results is shown in Table 2 below.

TABLE 2

sample 21-year-old mouse 6 month old mouse Pre dose (pg / ml) After administration (pg / ml) Pre dose (pg / ml) After administration (pg / ml) Comparative Example 2 5.46 ± 0.81 7.71 ± 0.03 8.04 ± 0.07 10.79 ± 0.75 Preparation Example 2 5.17 ± 0.24 17.52 ± 0.83 8.14 ± 0.66 24.40 ± 0.70

As a result of Table 2, in Comparative Example 2 administered with a sample containing only red ginseng extract and soybean extract, the level of estradiol was slightly increased in both young and old rats, bamboo leaf, Angelica, Cheongung, Baekjak, Baekbyeong, Baekbokyeong, In Preparation Example 2 administered with a sample containing red ginseng and soybean extract, the levels of estradiol increased significantly in both young and old rats.

Therefore, the herbal composition containing bamboo leaf, Angelica, Cheongung, Baekjak, Baekchul and Baekbokryeong can not only replace Dangguijak Paksan, but bamboo leaf, Dongguk, Cheonggung, Baekak, Baekchul, Baekbokyeong, Red ginseng and soybean extract improve the menopausal symptoms. As effective for, it can be seen that it can be developed as a food additive or a functional food.

<Experimental Example 3> Blood of the mixed herbal powder except for bamboo leaf, Angelica, Cheongung, Baekjak, extract, Baekbokryeong, red ginseng, soybean mixed herbal powder and bamboo leaf, and mixed herbal powder mixed with talc instead of bamboo leaf And Comparison of 17β-estradiol Concentration

Sprague Dawley female rats of 21 days of age were prepared in each group of 5 (average weight 50g) and 5-6 months old rats in each group of 5 (average weight 350g) was also prepared by the powder prepared according to Preparation Example 2 and Comparative Example 3 And the powder prepared according to 4 was orally administered for 3 days at 30 mg / kg body wt / day. The concentration of 17β-estradiol in blood before and 3 days after the administration of the sample was measured, and the average value of the measurement results is shown in Table 3 below.

TABLE 3

sample 21-day-old mouse 6 month old mouse Pre dose (pg / ml) After administration (pg / ml) Pre dose (pg / ml) After administration (pg / ml) Comparative Example 3 5.39 ± 0.83 6.55 ± 0.43 6.25 ± 0.88 7.10 ± 0.41 Comparative Example 4 5.15 ± 0.24 10.18 ± 0.60 5.53 ± 0.92 9.52 ± 0.63 Preparation Example 2 5.18 ± 0.28 16.54 ± 0.65 5.84 ± 0.07 24.06 ± 0.01

As a result of Table 3, in Comparative Example 3 in which the sample without bamboo leaf or tack was added, the estradiol level was slightly increased in both young and old rats, and the sample containing tack was administered. In Comparative Example 4 and Preparation Example 2 administered with a sample containing the bamboo leaf as a component, the level of estradiol was significantly increased in both young and old rats, especially in Preparation Example 2 estradiol levels It can be seen that there is a significant increase.

Therefore, female hormone is increased compared to the case of not using the taxa (Comparative Example 4) or bamboo leaf (Manufacturing Example 2) (Comparative Example 3), and thus it can be seen that it is effective in improving female menopausal symptoms. In particular, the use of bamboo leaves (Manufacturing Example 2) increased female hormones more than that of taxa (Comparative Example 4), so that the effect of improving menopausal symptoms was equally or better even if bamboo shoots suitable for foods were used instead of foods not suitable for foods. It can be confirmed that, it can be seen that it can be developed as a food additive or functional food.

Experimental Example 5> Acute Toxicity Experiment

In order to determine whether the bamboo leaf, Angelica, cheongung, Baekjak, Baekchul, Baekbokryeong, Red ginseng, and soybean extract of the present invention are toxic to humans, acute toxicity test was conducted using the herbal powder prepared in Preparation Example 2, ICR mice (n = 10-14) and weight change and survival (72hr) were observed before and after administration. All of them survived within the given period (72hr), and no LD ₅₀ was observed even at 6g / kg bw.

Through the acute toxicity test, it is determined that the food containing the herbal composition of the present invention does not adversely affect the human body.

The herbal composition according to the present invention can be prepared directly by tablets, granules or soft capsules, and can also be added to various palates such as tea and beverages to produce functional foods with improvement in menopausal symptoms.

The following examples embody the invention, but the invention is not limited to these examples.

Example 1 Preparation of Beverage

20% by weight of the herbal extract powder prepared in Preparation Example 2, 0.00075% by weight of vitamin B ₁ hydrochloride, 0.00075% by weight of sodium vitamin B ₂ phosphate, 0.00045% by weight of vitamin B ₆ hydrochloride, 0.00005% by weight of folic acid, 0.003% by weight of nicotinamide, The mixture was filtered by mixing 0.095% by weight citric acid, 25.3% by weight sugar and 54.6% by weight purified water, and the mixture was sterilized and filled for 20 seconds at 90 ° C or higher, and then sterilized for 30 minutes at 85 ° C.

Example 2 Preparation of Tonic Formulation

20% by weight of the herbal extract powder prepared in Preparation Example 2, 0.003% by weight of vitamin B ₁ hydrochloride, 0.003% by weight of sodium vitamin B ₂ phosphate, 0.0035% by weight of vitamin B ₆ hydrochloride, 0.0005% by weight of folic acid, 0.03% by weight of nicotinamide, 46 wt% of saccharides and 33.96 wt% of purified water were mixed and filtered, and the mixture was sterilized and filled for 20 seconds at 90 ° C. or higher, and then sterilized at 85 ° C. for 30 minutes to prepare a tonic formulation.

Example 3 Preparation of Granules

The crude drug extract powder prepared in Preparation Example 2, 35% by weight of vitamin C, 0.3% by weight of glucose, 28% by weight of glucose, 28% by weight of dextrin, 8.7% by weight of 70% ethanol were kneaded together and passed through a granulation machine to prepare granules of 60mesh granules. It was.

Example 4 Preparation of Tablet

35% by weight of the spray dried powder prepared in Preparation Example 2, 8% by weight of whey calcium, 8% by weight of lactose powder, 8% by weight of separated soy protein powder, 8% by weight of pomegranate extract powder, 8% by weight of lactose, 8% by weight of crystalline cellulose %, 6% by weight of inositol, 3% by weight of sodium aluminate, 1.53% by weight of casein phosphopeptide, 1.5% by weight of L-tyrosine, 0.35% by weight of γ-orizanol, 0.05% by weight of vitamin D ₃ , vitamin B ₆ hydrochloride 0.07 Tablets were prepared with a tablet press by mixing weight percent, sucrose fatty acid ester 2 weight percent, coating agent and food coloring 2.5 weight percent.

Example 5 Preparation of Soft Capsule

30% by weight of the spray dried powder prepared in Preparation Example 2, 8% by weight of fermented calcium lactate, 40% by weight of wheat germ oil, 15% by weight of soybean oil, 4.05% by weight of lead, 4.05% by weight of α-tocopherol and 0.005% by weight of vitamin D3 After mixing, homogenizing and emulsifying, a film was formed with succinate gelatin, dried in a constant temperature and humidity room for 14 days, and then screened and packaged to prepare a soft capsule.

As described above, the present invention provides a functional food that replaces taxa with herbal medicines contained in the food industry and at the same time has a function of improving female menopausal symptoms so that the application of the Angelica japonic acid may be applied to foods. By manufacturing various functional foods containing bamboo leaf extract, Angelica, Cheongung, Count, Baekchul, Baekbokryeong and herbal extracts consisting of red ginseng and soybeans, there is no fear of drug abuse or side effects, and it is prescribed by a doctor even if you feel uncomfortable in your daily life. It can provide functional foods that can alleviate the inconvenience of menopausal women.

Claims (4)

Herbal extracts prepared by hot water extraction method of bamboo herbs, Cheongung, Baekjak, Baekchul, Baekbokryeong with weight ratios of 1: 0.5 ~ 1.5: 0.5 ~ 1.5: 1 ~ 2.5: 1 ~ 2: 1 ~ 2 A food additive for improving menopausal symptoms in women. According to claim 1, wherein the weight ratio of each of the soybean extract containing 25% by weight or more of red ginseng extract and isoflavone by the hot water extraction method to the bamboo leaves prepared by mixing the herbal extract Food additive for improvement of female menopausal symptom as an active ingredient. Functional food having an improvement activity of female menopausal symptoms characterized by containing 5 to 45% by weight of the food additive according to claim 1 or 2 relative to the total weight According to claim 3, wherein the food is a functional food having ameliorating activity of female menopausal symptoms, characterized in that selected from tablets, granules, soft capsules or liquid formulations