CN113583973A - High-lytic Klebsiella pneumoniae RDP-KP-20007 and application thereof - Google Patents
High-lytic Klebsiella pneumoniae RDP-KP-20007 and application thereof Download PDFInfo
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Abstract
The invention discloses a high-lytic Klebsiella pneumoniae RKP-KP-20007 and application thereof, wherein a host is Klebsiella pneumoniae, the head of the phage is icosahedron and is stereoscopically symmetrical through electron microscope observation, the head of the phage is 72.640nm, the tail of the phage is 177.797nm, the phage is of the order of tailed phage, and the preservation number is CGMCC No. 22495. The Klebsiella pneumoniae RKP-KP-20007 has strong lytic effect on Klebsiella pneumoniae in poultry breeding environment, can efficiently treat Klebsiella pneumoniae diseases caused by pathogenic bacteria in poultry breeding, can be used as a disinfectant, and provides a phage source for industrialized, large-scale and programmed production of phages and treatment of poultry breeding bacterial diseases caused by Klebsiella pneumoniae.
Description
Technical Field
The invention relates to the technical field of biology, in particular to a high-lytic Klebsiella pneumoniae and application thereof in Klebsiella pneumoniae infection in poultry breeding.
Background
Klebsiella pneumoniae, belonging to the genus Klebsiella of the family Enterobacteriaceae, is a common gram-negative bacterium, widely exists in various environments in nature, and is a very common food-borne pathogenic bacterium. Klebsiella pneumoniae mainly infects humans and animals, can cause high mortality, and causes significant economic loss to the breeding industry worldwide. Animal products contaminated with klebsiella pneumoniae (e.g., meat, egg, milk, etc.) transmit pathogens to humans through the food chain, thereby creating a health hazard to humans and animals. The traditional Chinese medicine composition can generate septicemia, pneumonia and urinary tract infection, can cause death of people and poultry in severe cases, is one of important conditioned pathogens and pathogens, and seriously harms public health.
The bacteriophage is a virus taking bacteria as a host, has no cell structure, must be copied and propagated depending on the host, is widely existed in the natural world, has strong specificity and self-lysis capability, has the functions of lysing the bacteria and controlling the growth of the bacteria, can adjust the growth and the decay of the bacteria in the natural world, takes the Klebsiella pneumoniae bacteriophage as a biological bactericide to prevent, treat and control the Klebsiella pneumoniae bacteriosis in the poultry breeding process, has the advantages of low pollution and high efficiency, and reduces the influence of artificial activities on the natural world to a certain extent. Therefore, the natural enemy phage of the bacteria is utilized to solve the biological control approach with wide prospect for the bacteria.
The invention provides a safe and reliable lytic Klebsiella pneumoniae phage for treating avian Klebsiella pneumoniae, expands a phage stock library and lays a foundation for developing antibiotic substitutes for treating Klebsiella pneumoniae, aiming at the order of comprehensive banning of corresponding countries and solving the problems of bacterial drug resistance and antibiotic abuse.
Disclosure of Invention
The invention aims to provide a high-lytic Klebsiella pneumoniae RDP-KP-20007 to replace antibiotics in the prevention and treatment of poultry breeding, and solve the problems of untimely treatment due to acute morbidity of poultry animals, ineffective medication due to drug resistance of pathogenic bacteria and the like.
In order to achieve the purpose, the invention adopts the following technical scheme:
a high-lytic Klebsiella pneumoniae RKP-KP-20007 has a icosahedron head, is three-dimensionally symmetrical, has a head length of 72.640nm and a tail length of 177.797nm, is a long-tailed phage of the order of tailed phage, and has no virulence genes and lysogenic genes. The phage is preserved in China general microbiological culture Collection center (CGMCC) at 6 months and 3 days in 2021, and the preservation addresses are as follows: no. 3 of Xilu No. 1 of Beijing, Chaoyang, and the preservation number is CGMCC No. 22495.
Preferably, the Klebsiella pneumoniae (Klebsiella pneumoniae phase) RDP-KP-20007 has an optimum temperature of 37 ℃ and a potency of 10^11 pfu/mL.
Preferably, the Klebsiella pneumoniae phage (Klebsiella pneumoniae phase) RDP-KP-20007 has strong lysis effect on Klebsiella pneumoniae in poultry breeding environment.
The second purpose of the invention is to provide the application of Klebsiella pneumoniae RDP-KP-20007 in preparing medicines for preventing and/or treating diseases caused by Klebsiella pneumoniae.
The third purpose of the invention is to provide the application of Klebsiella pneumoniae RDP-KP-20007 in preparing feed for preventing and/or treating diseases caused by Klebsiella pneumoniae.
The fourth purpose of the invention is to provide a sterilization composition for preventing and treating Klebsiella pneumoniae, which comprises an effective amount of Klebsiella pneumoniae (Klebsiella pneumoniae phase) RDP-KP-20007.
The fifth purpose of the invention is to provide the application of the Klebsiella pneumoniae phage, which is realized by using the Klebsiella pneumoniae phase RDP-KP-20007 as a potential therapeutic drug or health product for bacterial infection caused by Klebsiella pneumoniae.
The sixth purpose of the invention is to provide an additive for preventing and/or treating diseases caused by Klebsiella pneumoniae, the effective component of which comprises Klebsiella pneumoniae (Klebsiella pneumoniae phase) RDP-KP-20007 of the invention.
The seventh purpose of the invention is to provide a cleaning agent or disinfectant for poultry breeding environment, which comprises the Klebsiella pneumoniae phase RDP-KP-20007.
The invention has the beneficial effects that:
(1) the invention discovers and separates a pathogenic Klebsiella pneumoniae BK-20007, and separates a Klebsiella pneumoniae phage RDP-KP-20007 by taking the pathogenic Klebsiella pneumoniae BK-20007 as a host, wherein the phage RDP-KP-20007 has strong cracking effect on the pathogenic Klebsiella pneumoniae BK-20007 in a poultry breeding environment, and provides a phage source for the industrial production of phage for preventing and treating the pathogenic Klebsiella pneumoniae BK-20007 in the poultry breeding environment;
(2) the Klebsiella pneumoniae RDP-KP-20007 provided by the invention is a virulent phage test phage separated from nature and does not contain virulence genes or undesirable genes; the invention does not carry out any genetic modification on the test phage;
(3) the Klebsiella pneumoniae RDP-KP-20007 provided by the invention has an obvious lysis effect within 4 hours after the Klebsiella pneumoniae RDP-KP-20007 is added into the environment, has stronger lysis activity and shows good application prospect.
(4) The Klebsiella pneumoniae phage RDP-KP-20007 provided by the invention has good application prospect in prevention and control of pathogenic Klebsiella pneumoniae of poultry animals.
(5) The Klebsiella pneumoniae RDP-KP-20007 provided by the invention can be used as an effective component of various products applied to environmental disinfection.
(7) The Klebsiella pneumoniae RDP-KP-20007 can be used as an effective component of various products applied to environmental disinfection, such as water distribution systems, medical facilities, aquaculture facilities, public and private facilities or other environmental surfaces in the forms of liquid soaking, spraying, combined use with an aqueous carrier and the like for disinfection and decontamination, and can effectively control the growth and activity of target bacteria. The liquid soaking, spraying forms include but are not limited to detergents, disinfectants, detergents, etc.; the aqueous carrier includes but is not limited to phosphate buffer, LB medium, chloride free water, etc.
(6) The Klebsiella pneumoniae phage RDP-KP-20007 can effectively kill Klebsiella pneumoniae on the surface of the environment and prevent and treat the pollution of the Klebsiella pneumoniae during the preservation process of poultry, and can be used as an effective component of various products for protecting poultry food. The present invention includes, but is not limited to, the prevention of food spoilage caused by klebsiella pneumoniae infection by liquid immersion, spraying, use in combination with synthetic ingredients, and the like, and is particularly suitable for cooked or non-sterilizable foods. The liquid soaking and spraying forms comprise but are not limited to food degerming agents, food disinfectants, food preservatives and the like; synthetic components of the present invention include, but are not limited to, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, calcium propionate, and the like.
(7) The Klebsiella pneumoniae RDP-KP-20007 can be used for preparing a composition, a reagent or a kit; the kit can be applied to the rapid detection of Klebsiella pneumoniae, and comprises but is not limited to the detection of Klebsiella pneumoniae in a target sample in the form of test paper, a kit and the like, or the screening of target pathogenic bacteria in a clinical sample, so that the detection sensitivity can be effectively ensured;
(8) the Klebsiella pneumoniae phage RDP-KP-20007 can be used alone or in combination as a biological bactericide, a feed additive, or a therapeutic drug, a health product and a medical apparatus for bacterial infection caused by Klebsiella pneumoniae; the Klebsiella pneumoniae bacteriophage RDP-KP-20007 can be applied to treating or preventing infectious diseases caused by Klebsiella pneumoniae;
(9) the Klebsiella pneumoniae RDP-KP-20007 can be applied to industrial production, can be specifically amplified by host bacteria, can be highly purified by applying a standard virus purification method, and has excellent popularization prospect. According to the description of the invention and the common knowledge in the field, the Klebsiella pneumoniae RDP-KP-20007 or the composition thereof can be prepared into various products applied to the aspects of medical treatment, detection, disinfection, food protection and the like for industrial application by the technical personnel in the field. The product form can include, but is not limited to, the carrier carrying, the concentrated injection or the medicament soaking and the like, and the product is applied to the controlled host body surface, the oral part, the rectum, the inner pleura and other parts; as one embodiment, the carrier-borne form includes, but is not limited to, oral aqueous carriers, oral anhydrous carriers, cream formulations, and the like; concentrated injection forms include, but are not limited to, vaccine injections, pleural cavity injections, transvenous injections, etc.; dosage soaking forms include, but are not limited to, aerosols, rinses, and the like.
Drawings
The above and other features, properties and advantages of the present invention will become more apparent from the following description of the embodiments with reference to the accompanying drawings:
FIG. 1 is a plaque map of bacteriophage RDP-VP-21010 of the present invention;
FIG. 2 is an electron micrograph of bacteriophage RDP-VP-21010 according to the present invention;
FIG. 3 is a test chart of in vitro bacteriostasis test of the bacteriophage RDP-VP-21010 of the present invention.
Detailed Description
The invention is further illustrated with reference to the following figures and examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications can be made by persons skilled in the art without departing from the spirit of the invention. All falling within the scope of the present invention.
The method separates Klebsiella pneumoniae BK-20007 from diseased white-feather chickens in Qingdao, i.e. Mexico-farm, determines pathogenicity and drug resistance of the Klebsiella pneumoniae BK-20007 through experiments, separates a lytic Klebsiella pneumoniae phage RKP-KP-20007 from livers of the diseased chickens by taking the BK-20007 as a host, and determines genotypes of the RKP-KP-20007 through a whole genome sequence.
Example 1 isolation and identification of pathogenic Klebsiella pneumoniae BK-20007
Sampling the liver of chicken with Klebsiella pneumoniae bacterial disease, inoculating the liver to DHL culture medium by adopting a sterile operation method, and culturing for 18-24h at 37 ℃. The Klebsiella pneumoniae forms a light pink colony on a DHL agar plate, the large surface of the Klebsiella pneumoniae is raised, the Klebsiella pneumoniae is smooth and moist and is in a mucus shape, adjacent colonies are easy to fuse into a thick juice sample, and a long thread can be pulled out when an inoculating needle is used for picking.
And selecting light pink colonies, continuously streaking and purifying for three times, and performing biochemical identification. Culturing in a culture medium for transferring the Klebsiella pneumoniae from the DHL culture medium at 37 ℃ for 18-24h, producing acid on the inclined plane, producing acid and gas on the bottom layer and being negative in hydrogen sulfide. The biochemical identification shows that the test is positive in V-P test, positive in nitrate reduction test and negative in M.R, the test of Simmons citrate utilization is positive, the test of malonate is positive, the test of urease is positive, the test of lysine decarboxylase is positive, the test of ornithine decarboxylase is negative, and the test of glucose and lactose and the test of indigo substrate are negative.
Then, a single colony was inoculated into 5ml of LB broth liquid medium and cultured with shaking at 37 ℃ and 200rpm for 8 hours to obtain a uniform turbid bacterial suspension. Then, identifying through 16sRNA molecules to determine the Klebsiella pneumoniae, and naming one strain of Klebsiella pneumoniae as BK-20007; and the pathogenicity and drug resistance of BK-20007 are determined through experiments.
Example 2 isolation and identification of Klebsiella pneumoniae RKP-KP-20007
The liver sample for the experiment is collected from the sick chicken in the Qingdao, i.e. Memo-broiler farm in 2020 year and is used as a sample for phage separation.
(1) Isolation of phage RKP-KP-20007:
soaking liver 10 mg in 10ml LB broth overnight at 4 deg.C, centrifuging at 10000rpm for 5min, and filtering the supernatant with 0.22 μm microporous membrane for sterilization. 3ml of the filtrate and 3ml of the culture of the host bacterium in the logarithmic growth phase were taken and added together to 20ml of autoclaved LB broth, which was left to stand in an incubator at 37 ℃ overnight for the propagation of the phage which may be present. Taking 3ml of culture solution, centrifuging at 10000rpm for 5min, and filtering the supernatant with 0.22 μm microporous membrane for sterilization. The filtrate was assumed to contain phage. The culture medium is diluted with LB broth in a gradient manner, and is cultured with a host proliferation solution in logarithmic growth phase for 19-23h at 37 ℃. If the transparent plaques appear on the double-layer plate, the existence of the phage is proved, and if the plaques do not appear, the existence of no phage is proved, and the rescreening is needed.
(2) Purification of bacteriophages
The phage obtained by separation is not a kind of phage, so further purification is needed, bright, smooth and small plaques are picked from a double-plate with obvious single plaques, the plaques are placed in physiological saline, a pipetting gun is used for repeatedly blowing and beating, a 0.22 mu m microporous membrane is used for filtration and sterilization, LB broth is used for gradient dilution, and a gradient preparation double-plate capable of obtaining single plaques is selected. Repeating the steps for 4-5 times until the obtained plaques on the double-plate have the same size, shape and definition, and finishing the phage purification. The results are shown in FIG. 1, which show that the plaques are consistent in morphology, size and definition and are typical lytic phages.
(3) Determination of phage titer
Single plaques of the purified phage were picked and added to LB broth, together with the culture of the host bacterium in logarithmic growth phase, and cultured at 37 ℃ for 6 hours with shaking at 170 rpm. Increase of phageCentrifuging the culture solution 5ml at 10000rpm for 5min, and filtering the supernatant with 0.22 μm microporous membrane for sterilization. 10-fold gradient dilution to 10 with LB broth10Get 10 times8、109、1010Double-layer plates were prepared with 0.1ml of the dilution of the double dilution and 0.1ml of the host cell growth medium, and the titer of the phage was measured.
Wherein, the titer of the phage (pfu/mL) is the number of plaques multiplied by the dilution multiple multiplied by 10; the titer of the phage can reach 10 by determination11Pfu/mL. The phage has an optimum temperature of 37 deg.C and titer of 1011pfu/mL, the phage can be stored for a long time at-80 ℃, and the titer is maintained to be stable.
Example 3 morphological Observation of phages
Applying a phosphotungstic acid negative dyeing method: phage multiplication solution 20. mu.L (titer 10)11pfu/mL) was dropped on a paraffin plate, and a copper mesh was placed thereon for 10min and then removed to adsorb phages. Drying at room temperature for 2-3min, dyeing with 2% phosphotungstic acid water solution, sucking water after 2min, naturally drying for 5min, and observing phage morphology with a microscope.
As can be seen from the electron micrograph (FIG. 2), the phage RKP-KP-20007 has a icosahedron head, is three-dimensionally symmetrical, has a head length of 72.640nm and a tail length of 177.797nm, belongs to the long-tailed phage family of the order of tailed phage according to the latest classification and naming of the phage.
Example 4 phage genome sequencing
After enrichment culture of a single phage, centrifuging for 15 minutes at 8000g under the condition of 4 ℃, adding 10% PEG8000 and 0.5M NaCl, standing overnight, adding equal amount of chloroform, mixing uniformly, standing for layering, centrifuging for 10 minutes at 5000g, removing a chloroform layer and a PEG layer, adding restriction endonuclease for digestion treatment, suspending the phage under the condition of gradient density cesium chloride, dialyzing for 3 times by TM buffer solution at the later stage, and performing whole genome sequencing by Chimona genome biological sequencing company. The whole length of the phage genome is 1251bp, and has no virulence genes and lysogenic genes.
Example 5 optimal multiplicity of infection (MOI) assay
MOI means number of phages at initial infectionThe ratio of the amount to the number of host bacteria, 0.5ml of phage multiplication solution (titer 10)11pfu/mL) was diluted 10-fold in LB broth, and 0.1mL of the diluted solution and 0.1mL of the host cell growth solution (10 mL) were each diluted at an MOI of 1000, 100, 10, 1, 0.1, 0.01, and 0.001, respectively6fu/mL) was added to 5mL of LB broth, and cultured at 37 ℃ for 8 hours with shaking at 200 rpm. Centrifuging the culture solution at 10000rpm for 5min, and measuring the titer by double-layer plate method, wherein the combination with the highest titer is the optimal infection complex number. The results are shown in Table 1.
TABLE 1 optimal multiplicity of infection test results
As can be seen from Table 1, the optimal multiplicity of infection for bacteriophage RKP-KP-20007 is 0.01
Example 6 in vitro bacteriostatic experiments
The titer of the diluted solution of the phage is 108、107、106、105、104、103、102、101pfu/mL) and host bacterium proliferation solution (10)5fu/mL) was added to 100mL of LB broth, cultured at 37 ℃ under 180rmp, and 3mL of each was taken every 5min to determine the OD value. The negative control group was 100ml of LB broth; 2ml of host bacterium proliferation solution (10) was added to the positive control group5fu/mL). The total time is 16 h. The results are shown in FIG. 3.
As can be seen from FIG. 3, the titer of phage RKP-KP-20007 was 104And the inhibition of the host bacterium BK-20007 in vitro can reach 15h, has extremely high production value, and can be sterilized by a low-concentration phage preparation.
Example 7 phage lysis Spectroscopy assay
And (3) carrying out host spectrum determination by adopting a spotting method. Adding 0.1ml strain cultured to logarithmic phase into warm semisolid culture medium, mixing, pouring into prepared LB agar plate, solidifying, and collecting 0.01ml titer 1010Dripping fu/mL phage on the surface of the upper flat plate, drying, culturing in an incubator at 37 ℃ for 4-6 h, and observing lysis conditionThe method is described. The host ranges are shown in table 2.
TABLE 2 bacteriophage lysis Spectroscopy test results
| Klebsiella pneumonia number | Cracking property |
| BK-20001 | - |
| BK-20002 | + |
| BK-20003 | - |
| BK-20004 | - |
| BK-20005 | + |
| BK-20006 | - |
| BK-20007 | + |
| BK-20008 | - |
| BK-20009 | + |
| BK-20010 | + |
| BK-20011 | + |
| BK-20012 | - |
| BK-20013 | + |
| BK-20014 | - |
| BK-20015 | + |
| BK-20016 | + |
| BK-20017 | + |
| BK-20018 | + |
| BK-20019 | + |
| BK-20020 | + |
Note: -the phage do not lyse; + phage lysis
20 Klebsiella pneumoniae stored in a laboratory are selected, the cracking spectrum of RDP-KP-20007 is detected by a spot method, and the strains are separated and identified from livers and dejecta of broiler chickens and meat ducks which are ill in Shandong, Henan, Liaoning and the like in 2019-plus 2021. Serotypes, identified by the K antigen, are of the following types: k1, K2, K3, K5, K20, K54, K57. As can be seen from Table 2, the phage RKP-KP-20007 can lyse 65% of Klebsiella pneumoniae.
Example 8 phage 80 ℃ Hot air treatment experiment
Taking phage multiplication liquid (titer 10)11pfu/mL)1mL, treated in hot air at 80 ℃ for 10min, 20min and 30min, respectively, and the titer was determined. The results are shown in Table 3
TABLE 3 phage 80 ℃ Hot air treatment results
As can be seen from the data in Table 3, the phage RKP-KP-20007 can survive for 30min at 80 ℃ and the titer can reach 107pfu/mL。
Example 9 drug susceptibility of host bacterium BK-20007
The drug sensitivity of the host bacteria was determined by measuring the Minimum Inhibitory Concentration (MIC) of the drug by the broth dilution method. The results are shown in Table 4.
TABLE 4 drug sensitivity test results of host bacterium BK-20007
Note: r is drug resistance; i, intermediary degree; s: sensitivity of
As can be seen from Table 4, the host bacterium BK-20007 is resistant to 10 of 16 antibiotics and has strong resistance, and RKP-KP-20007 can solve the problem of resistance of BK-20007 to the above antibiotics.
It should be noted that the specific embodiments are merely representative examples of the present invention, and it is obvious that the technical solution of the present invention is not limited to the above examples, and many variations are possible. Those skilled in the art, having the benefit of this disclosure and the benefit of this written description, will appreciate that other embodiments can be devised which do not depart from the specific details disclosed herein.
Sequence listing
<110> Ray union (Qingdao) bioengineering Co., Ltd
<120> high-lytic Klebsiella pneumoniae RDP-KP-20007 and application thereof
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<170> SIPOSequenceListing 1.0
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tgcgaatgct tcgtcgttag cctgtacagt cgcaatgaag tcgcccggat tagggagaac 120
gttacgaata atgttggaat acgcacggct gtgaatattc tcaaagtaac tccactgaat 180
aagcatacct tccagctcag gacgagatac cagtttcaaa atagcatctt ccggagcacg 240
ggtgataatg gagtcggctt gggtttgcca agctaagttc agcagggtct tgtttttaat 300
atgctgaggc agattaggcc attgtttctt atcggcttcc agggagatct cagtctcaac 360
ccagaactgc gagcgttgca gtaacgccag ttcctctaga cgagggtagc gaacgtttac 420
atagtcggcg attcccaggt cttggcccag gaatagttta gactcagtgt gatcccattc 480
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acaaaaaatc caacctactt gcaaataaaa ttttgctttc ggttggatcg agcttaatta 600
cagagtacaa ccaccgctgg aacagccttg ttctgctgcc gaaccaccgt tatctacgtc 660
aaagtttgcg tagtagaggt tcttaatccc atatttagtg gagttaagga gatctttgat 720
aatctcagta cccggaatga tacctccagg atatttgtta aagtcgtagt acaggttggc 780
actaatggcc tgatccgtga acttctgcag aactgctaac cacttgatgt gctcagtacg 840
atcaatatcg aacgcatact tataggactg catggtgtcc caatcgtcta gacccggggc 900
tacggtgatt actttgttaa cgcccgaagt cttgatagtt actgcactgc gaggaggctc 960
tactgcgttg gtaacaccaa tcagtacaga gctagactca cccggcatac ttgcggtcag 1020
aacggagtta cgcataccat gagctttgat ctcttcacgg aggctctccc agtccatttc 1080
tagacctacg gaaaccaggt catccacagt cttcttgtaa gtatcgatta acagtgtacc 1140
atcagaagtg tgagtacggt ggaaccattc acatgggccg atctcttttg ccagacgtac 1200
agacgctttg tgaaggaaga acgatgcctt ctctgcctca cggtggatcc agttacgggc 1260
ttcttcgcct tcgaatgcca ggccttcagc ggccatcgct cctgcagcgt tcatcagtcc 1320
aatacctacg ttacgacggc gtaatgcagt gtacttcata gccgggaacg gatagtgctg 1380
aatctcgatg atagtatcaa cgaatttcaa caggatgtaa gagatcttct cccattcttc 1440
cagagttttg atacgaccta gggcgaatcc gcctaagttg cacagggata cttccccata 1500
ctctgaaaca tccattttat ccagttcttc gtctgtacgg tacagatcta ttacgtgagg 1560
gatagggaac gttggctgta cgatctcaac acaaaggttg gacatacgca ccggatcttt 1620
gtaacggctg ttgcggttca cttcaccagc gtccatagtg tacaggcggc ccgtttccat 1680
acgtacagtt ttccagaact caattagttc tgcggcagga atcactgagg ctacagggag 1740
aacttcaccc ttgaaaccac gtttggtaac gcccgctaga cgtttttcgg ctgcaatgta 1800
caggcgttca aattctgcta catcaccaga gtcgaatgct gcgtatactt ctggagcgta 1860
caggaagctc attagtgtga tgttctcttt acgcaggaag cgtttcagga gaatactgtt 1920
gaacttcagg ttgtagtcca tcttatcgat tttcttttca tcaggggaac ggttgctctt 1980
agcttccatt acctgaatga tttccggatc gaagaacgca gtgtaaacgg ttgcagaacc 2040
gccacgggac tgctgggtgt tagcttttac ggagcggtcg atgtgtcgat aatatggcag 2100
ttttccagag tgtgggaacg cgccttttcg caccggatca gcaattgatc tactctcaag 2160
atgatagccg atccctgctc gggcagcgac cattttgaag acgacgtgct ctgctgcgtc 2220
aatggagtcc agggtgtcag taccatcaac aagacagcaa gaagcgaagc ccctgtcagc 2280
gctccgaagg cccacgagcg gcggagttgg gacgttgatt ttctgtagcg acagcgcgtt 2340
ataaaggtcg attgcatcga gcatactcca gtgaggttga gaaagcattg ccattgccat 2400
gcccatgtag gcaaactgcg gagtttcata gatctcttcc gtataaatat tacgtctaga 2460
gtatttatcc atgaactgct tcagaccagc attagtgaac agttcgtcac ggctgtggtc 2520
gataacttcg tttagagctt caaactggtc gtcagagatc cagccgctca tatcttccca 2580
tgctcccagc tctaccatgt ggtcgtggaa gaaacgcaga gatggcgggg tgtaagaatc 2640
aaataggttc ttacgaagct gggctaaacg cagctctagg gcgaatcggt cgtaacgatg 2700
atcacgctcg atcattgatt cagcagactt aatgagcatt gtttgcagat cgtctgagtg 2760
tacatcacct ttcggtaggt tcttaactgc ggctaccgct accggagacc acggcacatc 2820
gcttcggata ccgatgtatt ttgcccagtc attcagcttc tgagccatga acggttcttt 2880
tgtaccgtca cgcttgataa cgtattcaat acgttgggtc attggtagct ccttttggaa 2940
gttgtcagga tttaaaagat attctacttt gttttcggcc attttgcaaa tgagatttta 3000
ccgacaaaaa cgggcaacct ctttcgaagc tgcccgtggg ttggtctact ttaataaaag 3060
tgtaattttt tcattcgact aactaactct ttagtaccga ggggttggtt aggaaactcg 3120
tttgctatct tgaaagcggc atggtgtcgc cgctcatcct caggatagtt agcattgtat 3180
ttattgactg ttgccaggga tactggatgc accttcgttt tacgggtgcg gaagttgttc 3240
agtgtaaata cgttgttcat acgcgctcct agagttagag gtcaggacgt tcgtcgtgag 3300
aagtgatacc ttcaccgaag cctacaaagc cccagttttc ttcagaggta ataccctcac 3360
cataaccaat gatcagttca gtaaccatat tagattccca tatcgttaaa gattgcctgg 3420
aatgctttgg attcagcgga acgcacgtta tcatgcaact ctactaagga gaatggcaca 3480
tgttcgtact gatcgtagat atccatgatc agttgcagac cagaatcgga tttaatgtct 3540
ttctgcgcta cgtcgccaca gattactaat ttgcaatcct gacctacgcg ggttagaata 3600
cacttcattg cttctacgga gatattttga gcttcgtcaa caattacata agaattgttg 3660
aaggtacgac cgcgtgcatg ttcgatagca aggtattgga ttgccttgcg ttcaaccagc 3720
ccctgataag aacgttcccc taaggcccat ttaaagccat cggcgattgg ttctaaccac 3780
ggtgccatct tctcgttcag atctcctggc agcatcccta gggatttacc aagaggttcg 3840
ttcggacgga ctaggatgaa cttctcgtac acagaaccag gcgttgctaa ctcttgagca 3900
gcgagaacag atgggataaa cgttttaccc gtacctgctt ctccgatacc aactgttacc 3960
gtaaagttac ggatagtgct gatatagtgt ttttgctcag cgttcttcgg cttgagttct 4020
tttgcggttg gttgaaaacg ctcccgtgct tcaaaatcaa cggggatgac gttttcgtga 4080
cgttcacgtt ttgcgctacc gttacggcgc gactccttac gacgtgctgc ttttctcatt 4140
gcgatctcct tagaggtcta cagagggtca aatttcgacc atgtttatca atttagaata 4200
ccagtatacc aagttttggc gtggattgca actgaaattt tctaggatga tatggaggac 4260
ggatcctttc ctttattcgc gcgatgcgcg ggcgcacacg aataatataa aatgagggag 4320
ataagcaaat aaaattttcc agtttttatt gttttgatga tccagatcaa gttactgttg 4380
attataataa aataaggttg acatagctgt gcctatttgg tataatatat gcctaactgg 4440
aggaatatat gaacgaatta gacctgattg ataatatcta tagtatcctt gataacgagg 4500
gtgaagaaga ccttatgttt aataatgcta ataaggcaag cgagcagttt cctacacaga 4560
gggacatgat agctggagag gtttctaaat atgtggtggc acaggagctt ccagcatacc 4620
tattgacggc gcataatagg ggggagatac acattcacga tatggactac cgcgcacaag 4680
ggtatactaa ctgctgcctg gtggatttag cggggatgtt taagaatgga actaaaattg 4740
gtggagcaga gattgaaact ccaaagtcta tctctactgc agctgcggta actgctcagg 4800
ttatcgccca ggtaagctca tgtcagtatg ggggtacgtc tatagatcgt attgacgagg 4860
tctttgcccc atatgtccgt aagtcctatg ataagcactt agctattggc cagcgttggc 4920
tgcacgatag taagaaggct gcggtatacg ctactgaaat gacggagaaa gaagtatatg 4980
atgcttgcca ggggctagag tatgaagtta acactctatt caactccaac ggtcagcagc 5040
cctttgtgac atttgggttt ggtctaggag aatcctggga ggcacgcatg ttgcagaaag 5100
ctatgctgga agttcgtata agaggcctag gtgcttcagg gcatactgct gtatttccta 5160
aacttatttt tgcagttaag gaaggactca ataagtcccc aagtgatcct aactacgata 5220
tcaaacagct ggcgctcatc tgcacttcta agagaatgta cccggattac gtgagctatg 5280
aaagagtatc ggctgttacg ggtgatttta agttccctat gggttgtcgg tctttccttt 5340
cggctattga atcgggagaa actgctgggc gcaacaacct aggagttgta tccattaacc 5400
tgccgctagt tgctgtagag tctgagggat gtttcgatag attctggaag ttgttggacg 5460
aatacattga taaagcgatg gctgcccacg attgggctat tgagcggttg aagcgtgtgc 5520
gtgctaaaca ggcaccaatt ctctatatgc atggagcctt tggggtaaga ttaaaagcca 5580
atgatcttgt atggcccatc tttgagggca gggcatcagt gtccttggga tatatcggta 5640
ttaacgagct gattgaggta atgtttgagg ataccgaccc tatgtctcca cctgcggttg 5700
aattttcagt acaggttctc aaccacatga aagatcgttg caacagaaaa gctgaggaaa 5760
ctaatcttgg gttcagtctt tatgctaccc cgagtgagtc cctgtgtaac agattcaaca 5820
ctaaaattgc cgaacagtat ccagagtatg actggctaac ggataaaggc tacctgacta 5880
atagtcacca cctggatgtc cgtacaaaag ttgcccctaa cgtgaagttt gattatgaag 5940
ctaattttac taccatcgcc aatgggggta atatatcctt tgtagaactt cctgagatgc 6000
gtaagtttat ctctgcacta gagtgggttg ttgactatgg attaagtaag tcccactaca 6060
taggggtcaa cattccagtt gatgaatgtg aggggtgtgg gtatttaggc gaatccgtat 6120
ccggagagca tggttttgta tgcccccaat gtgggtccgg gaatatctca gttacccgtc 6180
gtgtttgtgg gtacttaggt agtcctggta gtagaccctt taaccccggt aagcaacagg 6240
aagtaatgca acgggtcaag cacatgaatt tgaaataaat cacttgctaa acacctccgt 6300
ttttgatatg atagttgtaa ttgagaaacg gaggatttat gaaaatccat aaaactgatg 6360
aaaagcgtat ctactttatg atggactctg gagcatacgg atctatttcc cgagaagacg 6420
tggtaaaact tctgcgatgc cgtaaccact tgtggaaaga taaagtcgat cccagaacct 6480
ctgagtgctt gtccgaaaag gcggagcagt tgcggaaaga agaaatgaga aactatatgg 6540
agttactgta atgcgtagat tgattattgt aagtggtgct gggttgagcg cagatagcgg 6600
agtccccacg tttcgtaagg gtgctgtcac cccactgtgg gataaataca agctaactga 6660
agtgtgcaac atccaggcgt tcgataaggg gtttcattat ctggacgacc ctatgccccc 6720
gttggaagcc ctttctgagg gtactgatga cgagcctagt cgtaacctgt atgaactgac 6780
ccatgagttc tacaacatga ggcggcaaga gctaggtacg gtggagccta acattgctca 6840
cttgagaatt gctgagtggt atgaacgctt cccaggtcaa gtcgttaact tcaccactaa 6900
cgtggatgat ctgctagagc gtgctggcat tccccatgat gatgtgatcc atgctcatgg 6960
ctacctgacg gagataatgt atcgccgagg taaagatgtg atcgtggaag atatcgggta 7020
cactgcggtt gattaccgta agtatgagtg ggttaagcct gcaattacgt tcttcgggga 7080
aactgctccg tggtatatag ggcagatcaa cctgtttgat accctgacaa cccaggatct 7140
ggtaatcgtt gttggtgcca gtaaccaagt aatcaacttt aattgggaac tattcccggc 7200
ccatagtcga ggtactaagg tgtgggtggt aaacaacggt attaattacc tagagcagag 7260
tttgtatgaa gaacgtggga tccctgtctg gtatgatact gctgctaacg tgtttagcaa 7320
caaacatttc ataggtcaag ttgaggcttg gctggaggag aaaatttatg taccatcccg 7380
atgatatcct gttatggcct aacggtagtt ggtgttatcg cagtgatgta caagatatga 7440
gtcacctatc ggacgactat caggttttac gagcggactc tgagcagtgg cacgaattca 7500
ttcaaatggg agaagaatat gctggtcaat gaaaaggttg ttaatgaagg ggttgggcta 7560
gttccctggg ctgaaattcc tttggacgta aaagagtctc tactggacca tcttcgtgtg 7620
tggtgcgata atatggaggt atacttcgat tatgacaaca tgcaccttgg gctatgggtt 7680
cctatggacg aagatcaaga tgaagtccta gactggggcg atctgactga gatggggctg 7740
gtatttgcac taggctacgt gtgtctgctg cgtgagtcct atatcccggt tggggttaca 7800
ggtgtttcag caggtatttg ggtcggacgt aatgaagatt attatgctcc ggaaaatatt 7860
aacagttgga tccaggtgct gcgtcgcttc ggtttccaag ttgaagggtt gactaaatga 7920
gtattcctaa aatggaacgt atctcctggg cggatatccc caaggaattg attgatgtag 7980
cagagaatct gctgcgaacc gcgttgaggg acgaggagct ttgcttcatc atccagcatg 8040
acgtgtgtgt tggtttgtcc aaaggtagtt tggcccagga ttatgagatc ctctttgatt 8100
gggatgacct ctcggacttg gggctaatgg ttctggtgaa caacgttgtg ttccacccct 8160
ctaactttgc agcattccgg gaaccagggg caggtatttc tccggggttc ttggtagctg 8220
acgagccttg gacgtatgcc ccagagattc ttcgtgaggg caaacaaaat gcctcttcta 8280
actcaattaa tattatgggt tggaatgcct agttgaacac ttagaccagg ggattatcct 8340
ctggtctttt ctatgtttaa acccagttac ctaccacgta tttaaatatt ttacttgcaa 8400
tctcgccacg atttttatat aatatattca taggttgaga gaaatgatgt gagttacgaa 8460
actgacataa ttcctctcat tcacttccga gcatacagaa cagtccggct gctacatgct 8520
tggttgggtt tggcttattg gaaaattgat tccgaacgga attatagata attgatctag 8580
aatgcgggta agagaggttg gcatcgcgag gctctcagat atttgttcgt tagtcatgtg 8640
gagcaaatag caccgcggtc tgaaatgacc aagaagtgaa gctgtaagta gcaacgtacc 8700
tctgcgcaat agcgacgaat aggggtcaac cacatggagc ttagcggcga ttacatgctg 8760
tgtgggagtt gtgcgaagcg gccagttcta gcaatgagga agtgaccacc cctccatcta 8820
taaggaaatt tgttgagtca gtggactttt aagctgttct atccttgata gttcgagatc 8880
gctttattct tcaacatagg agaaaacgta atgttttcta ttctagaagg acacgcgggt 8940
ttttcccgcg atcccgcttc cggcaattgg aaggaagtga agacaactga ttaccttttt 9000
gcgaaggagt tttctcacga gcatccagaa ggtaagccag cctcaatgcc ctacaaattt 9060
aacgtagtgg atacggttga tccaaaaaat cttaatgaag cgtatgagct gatggttcag 9120
ctcactcaag atccacatct cgtagcagta cgaggtacat gcttagttgc agagaaggcc 9180
gtgcgtcgta aacgtactaa cttcaaaatc gaccataaga gcaatattat tgctatggac 9240
gtcgatggaa tctccgatac tggaggatgc gacaaatttg acatcgtggg gatgggacgt 9300
catgttatta agttattaaa tagcatcagc gaggacatgt tcccgcttaa cgcagggttt 9360
attgcccatg cgtcgtcttc ggctggaatt aagccaggga ttcgtatgca catgctatta 9420
gagagtaata ttcctgttac tcagggtcag ttaaagtttc tatttacgtc tctcaacgat 9480
agctctcggc agaagtatgg ttttgatatt gccgacttag cttattattc atccgtacag 9540
ctacactatt tcgctgaccc gattttccgg gatcagttta ccgatccgtt taaagcggag 9600
ggtaagccac gtctggttaa agttaatggc gctaggattg aactgcccag cactatgcca 9660
gattacgaag ccactcgcgg ggaatttaaa gaagaatttc tgtctttact caatcagatt 9720
aaaggcaagc gtgtggcctc tgagaaggtg gagcaaacta ttgcagagct ggaagaagca 9780
gacgatggcg tttatctgcg tattattcct aaactgtacc acagagcgct ggaagacggt 9840
gttgatttcg catggcttga gaaagagatt acctcggcct tatccgatta catcaacacg 9900
aaggataact cccgtagtct tcaggactat tttaacaacg ggcgtaagca ggcgttaaaa 9960
gcgtttgtga acaactcgat gcgagatatt ccggagtcga atgttaaagg cgtccctgta 10020
cacaagttga cctctgatag ccccgatggg atgaactatt tgaagatcaa ccgtccaccg 10080
ccggaaggtc atctaacgtt tattaaggcg tctctaggta ctggtaaaac caccgcagtg 10140
acaaagtggc tagaacgtga tcagctgaaa ggtaatttcc ttgcagttac gaacacacgt 10200
gccctagttt catctaatgc taagaagttt gaagccggac agtatgataa gtccgtagat 10260
atgttaaact tcaaacgcgg tgctattgat cgtatgtcca ccactattca ctcaatccac 10320
aagtttaaaa actttgttgg acagatcgat gttatcttta tcgatgagtg cgacgcagtt 10380
atgaatgacc tgttattcgc tccagttgtc aaacaacgtc gtgagtgtat ctcagttctt 10440
cgtgaaattc tgctatctgc aaaagtcgtt atcctgtctg acggggatat cagtgcggaa 10500
accattgagg catatggatc tctcatagat tttgacaagc cggtctctta ttataaacat 10560
catcgtaaga tgctctcgga tgctcaggcg tatgagttcc cggatgaatc tagtatttgg 10620
gttgccctcc aaacgtccct agagatggga gagaaatcta ttctggtgtc cgactgtggg 10680
ccggatgagt taaacgagaa aggcctgacg ttaagaagca atacaggtgc gattgttaaa 10740
gagattcact caaactctac atctgactta gatattcgtc gtattttaga ttatacaacg 10800
aatgagctaa ttgaacagca gattgattgt ctactgtgta gtccgtcggt aacgagtggt 10860
gttgacttca actacttcga caacgtattt gttattactc gtacagctaa ccaggcgcca 10920
aacatgcgct tccaggcaat caggcgcgac cgaggagcta agaatatctt ctatttcatc 10980
gataagtcca ccagcggatt ctctgcgggt tcggagcagt acaacattga tgagggttgg 11040
atggagttag cccagcaact ttacgttaaa cgtcgtgagc tagagtcccg taactttatc 11100
agcacattac gatactatct gctggatcaa ggggcaacta tcgatatctt cagcgaaagc 11160
tggggtaaga ttgatagctc agccgcagag tatactgctg aacgagtttc tgctattttg 11220
agcagtaccc cggattggtg tgcaccccgc catgcggacg catacgaagc caagctaatg 11280
ctagtcaagt atttccacct ggactctatt aagagtatta cacaggaaca tgcagagatg 11340
tggattagca agaaacctca caagcgggcg gagttcttcc ataaacttca agatatattc 11400
tggaaggata ttaagaagtg ttctaacgtg acgattagcc cctttattga agccctgaag 11460
aaacacaaga aggacttctt tattaggacg ggacagtctg ccaaccctaa gtatgcccgt 11520
atgtacttaa cccaaatggg tattaataag gaaatggaga cggaacagat cgtagactgg 11580
tatcgaacct actgctctat cgagggtatc tctgtaccgt atgagtttat gacggacgag 11640
gagaaggcgc tggccgatga agcgcaaaac gaacttggag tacgtaatga gcaagcgtga 11700
tgcccgctgg gagacaagga agtttcccaa acgcgatacg aaagcacgga aagccaaaga 11760
gatagagttg tgtagggtaa tacctattcg cctagcacag atgccaaata tttatgactg 11820
gctagaagct cagcgaaaga cacgcctttc tatacgcatc aacatggaac ttaacatggg 11880
gtacaagagt ctatctgaat tcatgcacgt tgctttcgac cctacgttct atgaaaatcg 11940
cgattgctta gaagctaaat ctgtattata atagtttcat aaattcgaga gaggataaag 12000
aacatggcaa tccgcaaaaa acttcatgcg aatagcatcc cggacgaaaa gtttaaggaa 12060
gcgattcagt ggctagaaga tggcaagacc aagaaaggcg cttgcgaaat cctcggagta 12120
gcatccaact ccacgatgga acgtttgatc gaggaatgga aagataacca gcgtgtttct 12180
gccgaaatgc gtaaaaagaa acgtggtact aaaatcgaag gggctgagct ggccaatgtt 12240
atcgattcgt atctgtctgg tgatagtttt gaggcaatcg ccgagcgctt ctaccgttcc 12300
gcaaacatga tccgaatggt tctgtctgct cacggtgctc tgctccgtgt taatggtgaa 12360
gtagacccac tcttccctcc tgcgattcca gaagaatcaa tgaaagaggt atttgaagta 12420
ggcgaacacg tttggatccc agggtaccag tgtattggtg aaattaagaa agctctggat 12480
aacccggtag gagcttaccg tatttacttg ctgtctgaat ccaaacagca gtatgttaac 12540
tacatgtatt gggatatagc ttctgtagaa catctggtag cacttggtgt tgatatcaag 12600
tctctgggtt tcaagtggag caaagaagac gtagctgaac tggttaataa tgctgtaaaa 12660
gcagccctaa aattagagaa gagaggcaaa ggtgaataaa tatcaactcc tgaacttatt 12720
ccagatctat tccgaaggtg ctacagctat ccgggatctg cactacgcag ttcccatgga 12780
cgaagcagaa gataacggct ggctcaccaa gtacgatcgt ggtttgctga agatgtatcg 12840
tttgtccccc aatggtttgg tagctgttaa ccaaatccta gaaaattctg tttgctttgc 12900
agctcagtaa cttgttataa tattctcata gtttgaaaca aaacttaaaa actcttttta 12960
acaataaata aggaagtaat aaatatgtct actccaactc aatggtctcc tgaactcgaa 13020
gctgaactga cttctgccta cgtcgccaaa atcgaactct tcccggaaga tgaacgtcct 13080
ggcgtttcca tggagatcgt agctgagatc gctaaagagc acggtgtttc tccgaacggc 13140
cttcgtatga agctgtccaa agctggcgta tacgtcaaga aagaagccgg taagtctacc 13200
actaaaactg gcggtgatgc tcctaaagct ggtggccgta cttctaagtc tgatgctcag 13260
gctgagctgc gcgctgcatt taacgacgct ggactggaag atggcttcct ggacgaatcg 13320
atcgtggaca aactgaccgg taaagctgcc tctcacctgg ctgaagctat ccgtaaaatc 13380
actaaataag agggtattgc aatgaataga gcacaagtcg tagctatctg tgaaaaacac 13440
ggtgagtttt gcatgcaata caccaaactg cgtaccaagg gggtaactta cctctacggt 13500
acgactgagt tcgatcctaa gcaagataaa tacctggccg agcgaatcgt ccgtgaaggc 13560
ctggaacccg ctgacaaaga tcatatcctg gtctttagcc gctctagcga taaattccgc 13620
tatattccga ttgcgaatat taagcgcatc accagcctca accaagaact tgatcgagct 13680
actccagtag gtcgttaaga cgcaatcagc cccttcgggg gctttttgtt tatctgagaa 13740
caataaaaat gaatcaaaac atttgtcagg attacgaagg acatattgat gatcagtccc 13800
acgttatctt tgaagatgaa gggcgacaga ttcgtatgac tgtctcggag tttaggggca 13860
atttatactt tggtttccga ttatggttac tagatattga agataactgg ttccctacta 13920
aatcaggctt ctcgttccct tacacgttag aaatgactag cacgctgttc agggcgttta 13980
ctaaaatact aagcaattca gaggttcttc atgaagttta ccgtgaatct caaaagaccc 14040
aagccagtga cgactaagtt gctggctttt tctttaaaat ctcaattgct tagtgtttta 14100
aaccttgata taatattctc atagtttgaa ggagatcttt atgaaagatc atgaaattgc 14160
tcagctagtt aataagctga ccgaagctgc taagacgtat gctcatactc agcaattaag 14220
agcacacatg tctaaaattg tcaaagaggc gctaaagaat gcgaaagata acacttgatg 14280
cgtacttcag tcccccactc cagggccaag agttaatcct aacatggatt gaaaaagaga 14340
agggcaaaaa tgtagttcgt actctcgaag ggtataagct cctaaacatg tggtacgaag 14400
gtactgagtt gcgctgcgaa ctatacagcc ctaagtctga acgaaacgtg ataacacttt 14460
tctattatct ttgccgagat ttcaattggg aaggaaagac caagacattg tgtgaccact 14520
acgaggttaa ataatgcaac acgttaaaga atttatcaag ctgtgccaag acgcgtacta 14580
caaaggcatg tcgattatct ccgatgaaga gtatgatgcc ttaatccgtc gttttccgtt 14640
agaagatgaa atcggcccca agggtgacat acctcacctg ttccgtatgt actccttaca 14700
gaaagtgtac ccaggccgcg gcgaggaagt acccttccag ggcattgaaa cgccgaagct 14760
cgatggttgt gctatttcac ttctgtatat cgacggaaaa ttcgtttctg cgttaactcg 14820
tggtaacggt attctaggga acgatgtaac tcataatgtg aagttactga acatacctaa 14880
gaagatctct caaaagaccc cggtgcagat tactggtgaa gtacacatca ccaaagaagt 14940
tgagaacatg cgtaacttcg cctctggtgc tattaacctg aaagattctg gagagttttt 15000
ctcccgtatt gcagaaggtg gcctgatgtt cacggcatat agtattcagt gtgaaactgg 15060
caaagttggc ctgaccgcta ctttctgtgg agatatgcat atcctccagg gtgatggttt 15120
tgttacctgt ctggatatct ccagtcgagt agattggttc ccaacggacg gcgtggtggt 15180
tcgtatggac ggcaacaatc agtttaacgc agcaggttgg actaacaagt tccctcgtgg 15240
tgcgtacgcc atcaaagaag acgatgaagg cgaggttact acgctagaac gggtagaatg 15300
gcaagttggg gcttccggta aggttactcc tgttggatac ttcaccccgg tagtcatcga 15360
cgacgctgtc atctcaaaag ctaccctgaa taacgttggc tatatcactg cccttgacct 15420
agaaatcggt tgccagattc gtgtaattcg tagtggtggg gttatccctc gcatcgtaga 15480
acgcgtttac gagtaacact tgattcaata gatacaccgt gatgattttt taaagtagtt 15540
attgacattt tcatcgccag ggtgtatact attatcattc agttgaggga aagaaatatt 15600
tggtgagaga ctgagctaaa ttctgaaaaa tttcgattgc ttagtcctga ttttcttgct 15660
ataatattta tataaattga tgaggaagaa aatcaatgaa aattgaaatt ccactgaatt 15720
gcccctcttg tggttcgaaa ctggacttag ttaacgatca gttgttctgc cgtaacaagt 15780
ctatgtgtcc agctcaaagc agtaaattaa tcgagaactt ctgctcaaaa atgaagttaa 15840
agggttttgg cccacagacg attgctaaac tggagatcac aaaagtttca gaactctttt 15900
tcctgactaa agaagattta gtcagagctg taggtgataa agtcgccacg aaacttgagc 15960
tagagttgga aactaagctg agacaagatg ttgactttgg ttcggttctt ggatctctta 16020
gtatccctct tatcggtgaa gttgctgcta agaaattatc ccagctttac aacgatttcc 16080
aatctgtgaa agcggaaggt aaagctggag aaaacttagc ttcgtggaag aatacaccgg 16140
caggacagga cgtaattaat ctaccatgga aattcagtgg ggcgcgggaa actcaagtta 16200
ccccggctac tgaatccaac ggagttgttc tttgcattac tggtaagctc aacgacttca 16260
aaaatcgtgc ggacgctacc aaatatctgg aaagtcttgg gtatacggtg aaaacctccg 16320
tgactaaggc tgtaaactac ttaatctgcg aagatgaaac caagattggt tcttcttcat 16380
acaaaaaagc acaatcgctg ggcatcgaag tcttgacgat taaaattcta ctggagaata 16440
aataaaaatg gctaaattaa cctggaacga agaaatcact gcatccctga ccgctaaagc 16500
taacgctctg aacgtgaccg ttatctctca ggaagctgtt gctaacatcg ctgctgaact 16560
ggctgctgaa actggtaaag aagttaccgc tcgttcggtt ggttctaaac tgcgtaaaga 16620
aggcttcgaa gtgcagaaag catccgacgt aaccaaatct ccgtggactc cgggtcagga 16680
agatgaactg gttgcattcc tgaacgatca tccgggtcag tatacctacg ctgaaatcgc 16740
tgctgctgta gttggtggtg cttataccgc taaacaagta cagggtaaaa tcctgagcct 16800
ggaactgact gccgctgtta agccgactga aaaggccgct gctgtacgta gctttagccc 16860
ggatcaggaa gctgctttca ttaacgccgt tgccagtggc gcatccgttg aagcaatcgc 16920
tgctcagttc gaacgtaccg ttaagcagat ccgtggtaaa gctctgagcc tgctgcgtga 16980
aggccgtatc gaagctatgc cggttcagga agtctctaat gctaaggcac gtgaagacgt 17040
tctggaaggt ctgaatatcg ccgacatgac cgttgctgag atcgcagaag caactggtaa 17100
atccgagcgt ggtgttaagt ctatgctgag ccgccgtggt atctctgcta aggatcacga 17160
tggtgttgct aagcgcgcta aacttgacgc taaatccgcc aagtaattga tttgacctga 17220
ggggagagga attttgttcc tctccccttt ttcgtttaag tagacgctaa cgcggcgtag 17280
agagtatctt atgtataacg tccaagcagt agttttgaaa atgctcctag cctccgatca 17340
aaagcaggtg gctctagaga cattctctag actgcgcaaa gatcacttca atgacgcatt 17400
taccgcgatc taccaagctg tccagaatta ttacaaaaag cataacggaa tgccttcgtt 17460
agatgctctg atgctagagt ctaacagaaa cgcaaggttg tctcaagcac taactgtttt 17520
agcaaacact cagattccag acgttgacat atcgcatgcg attcatgtcc tagagtcgga 17580
atacacacag gatctattcc tgaatctgct agaaactgat gtgttgcagg atattaccat 17640
actggatcag ggagaattac ttgatcgagt agcggctctg cacatgaagc tagaggaacg 17700
agtaacaacg actggtaagg tcttcaacgc cgatactatg cgtgttttta agagaaaaga 17760
agactcaatg ttaaatctta tctctctcgg catctcaaac gaatttgatg ctcaacttgg 17820
cggaattgcc agaaaagaaa cactgctact cggtggatgg cgtggtacag gtaaatcaat 17880
catctgttct aacattcaag tagcccagta ttacaacggg gatatcgccc catatttctc 17940
catcgaaatg ccagagaatg aggtctttag acgtaaccta gccattatgg ctggtgtttc 18000
agctaaggct atgcgcaatg actccttaca aggtattgaa ctcaacaaac ttgcgaagac 18060
tcgtgcaaaa atgttcgaag gcggtctgga agtatataac gattttgtat cacgttatac 18120
gctcaacgag atgagtgact tccatgacat ggagactatg ctaatgcagg aaagacccct 18180
gcacactccg atgatcatcg tgtatgatcc ggaacttagt acagcaacca tcgatgttga 18240
actaactaag ctaacctcca agtatgggga taaggtaaca atcgccctgc tagactatat 18300
caaccaggta cgtttgccgg atacgaagac attagatatg tatgattgga agcagcagat 18360
ggttgtgtcc tctacgttca agtctacgtg ccaaaagcat aacgttgctg gtgtagctcc 18420
ttaccagatt gaccaacagg gtaacgcccg tatggcaaga ggtattctcg attcctgtga 18480
tatggctgca aacctaaatg ctgctaaaca gaacgagggg catgacggtg caatcaagtt 18540
tgacttcgta aaaactcgta actccgaggg tatgacattc atgccgaaga tcaactggaa 18600
ctcattgcgt atggatcaga cttctgatct taaactagag gacattcgtc agatggaagc 18660
agagtttgtt atcccacttg aaagcgataa accgaaagac aaaccaaaaa ggaaaaaggc 18720
ttcggatgag gatactaatc ccaccggaga atcctcaaga gacttatgag tagaataacc 18780
gagcttttag atctcaaagg gattgaatac agagatacgg gtggggacat cctcatccgc 18840
tgtctcaatc ctgaccatga ggatgcacat ccaagtttac gtgttgaccc cgattcaggg 18900
gtttttcact gcctaagctg cggatttggt cgtggtatac caagcatctt tcattacttc 18960
aatgaagaac agtacaggac gtctcctaga ctcctgaaag ttcgcagaat gattagtgac 19020
ctccgaactg agggtcgcag tctagaaatt ccagaatcag ccatgatatt cgaccaggat 19080
tttcgtggta tcaaagcaga gactttcaaa aagtactttg cattccaaca aacagaggac 19140
tgggaaggtc gtgtagtgtt tcctattacg gatgccgtag ggagaaactt attcttctta 19200
ggccgtaata tggatagctc tgcccctccg aaatatatga ttagacccaa gaaggtctcc 19260
ccaccaatct tccctgttcg ctataatacc ccagccctaa tcctagtcga aggtatattc 19320
gacatgttga atctagaaga taaaggttgc cataacgttt cctgttgttt tggtactcac 19380
cagttctcgc tagataacat tgctgataaa ttcatgccgt tccaaatagc aggtacgact 19440
cacgtagtca tcatattgga caatgataag tccggtaacg aggcatctaa gaaattagcc 19500
aaattaatcc gtgataagac tagaattata ccaattatag gtaacttctt gcttccagag 19560
gacaaagacc ctggagacct agatgctgaa gaagtcgacc agctcatcag aaacgtagaa 19620
atcttgattg ctgaacatgt caagatttga tataataatt gggtaagttt gagaagaaac 19680
actgacgttt tacttgctta cctaatagga gaaatcaatg aaaattgcag ttgtagacaa 19740
atcaccgaat aacgtccgct atcagaaaca cttcgaactc tttgaccatg aagttgagac 19800
cttctttatg gctagtgaga aagtaaccgg gcgactgctc aagaaacata tcactatcgg 19860
aacaccggag aacccgttca atccggaaga ttttgattac gttattctgg taggtgcaga 19920
cccgttcctg aagtttgcag ctaaaaaggg catttccgat tactcaggta aacgtgttga 19980
gcatgatggg tatgctaact ggattgcaag tatcagtccg gcccagctcc actttaaacc 20040
ggaaatgaag cccgtatttg aggctaccgt agagagcatc cacgccattc tcaatggtcg 20100
tgaaaaacgc tctaaagcag gtgattatcg cccgattcag tgcccggatg aagccgaggc 20160
atacgtgaag atggtgtata ccatgtgtcc tggtatgatc gcatacgact ccgaaactag 20220
tgcgctgtac tgccgagatg gttacatgct agggatctca atctcccacc aagagtatca 20280
aggcgtgtat attgacgcag acgtcatcac cgaaaatacc gtctattact tacagaaact 20340
gttcgatagc ccggaacatg gtgttgtgtt ccataacttg aagtttgata tgcacttcta 20400
ctgctaccac ttaggtttat cctttgataa ggcagcagaa gagaaacgcc tccacgatac 20460
catgctgatg cactacgccc tggatgaacg acgtggtaca cacggtttga agtctttggc 20520
gatgaagtat accgatatgg gggactacga ttttgaactc gaccagttca aggagacgta 20580
ttgcaagacg cataagatca agaaagagga tttctcgtat gatctcattc cgtttgatat 20640
catgtggcct tacgcagcga aagataccga tgcaacactg cgtctatcca acttcttcct 20700
gccaaaagtc gaagctaacc ctcgactgaa gtctctgtac tacgatgtac tgatgccggg 20760
atgtgtattc ctacagcgca tggaagaccg tggtgtacca atctccaaag atcgtctgaa 20820
agaggctcag gttcagttaa tgactgcgct acagctcgca aaggctaagc tgtatgagta 20880
tccagaagtt cgtaagctag aagaagatca aggctcggtg tttaacgcag cctctgttgt 20940
ccagctccgt aagctcctgt tcgattatgt tgggttaacc ccgacgggta tcatgacaga 21000
tacgggtgca gattccactg gcgcagatgc cctgaaagaa ctttcagacc aacatccgat 21060
agctaagact ctgctagaga ttcgtaagat ctccaagctg ctctcgacgt atatcgagaa 21120
gatgctgatc agtatcgatg ctgacggctg cattcgtact ggattccata tccatatgac 21180
tacatccggt cgtctgagtt cgtctggtaa gctgaacctc cagcagttac ctcgtgatga 21240
gtctgttatt aagggttgta ttgttgcccc tatcggttat cgcattatcg catgggactt 21300
aacaactgct gagatctact atgccgctgt actgtctggt gacattaaca tgcagcaagt 21360
gtttatcaac atgcagaacg acccggaaaa ctactcggac ttccacggtt caattgcaca 21420
catggtattt gccctgccgt gtaaaccgac tgaggttaaa aagctgtatc cagcactgcg 21480
tcaggctgca aaagcgattt cgttcggtat tctttatggt tctggcccgg ctaaagtagc 21540
agcgtcagta aacgaagctc tcctagaaga gcacatgaag actggtaaac cgtatactga 21600
gtgtactact ggggatgcga aagagtacat cgaaacctac tttggccgat tccctcagct 21660
taagaaatgg atcgataaat ctcactctca aatccagact aacggcttca tttacagcca 21720
ctttggccgt aagcgtcgtc tgcacaacat taactccgaa gaccgtggtg tacagggtga 21780
agaactgcgt tctggtttca acgccatcat tcaatctgca tcttctgata gtctcctgct 21840
aggtgctatc gataccgata atgagattcg ctctcttggt ctgcaggacg aaatgaagat 21900
tatcatgctg gttcacgact ccgtggttgc cattgttcgt gaggatttag ttgatcagta 21960
taacgagatg ctaatccgta acattcaggt agaccgtggt atcagtatcc caggctgtcc 22020
gattggtatc gactctgact cagaagctgg cggttctcgt gattactcct gtggtaagat 22080
caagaaacag cgtccttctg ttgcttgcat tgaggacaag gagtttgagg agaaagtacg 22140
tagtattatc ggtatggagg acttcgatta cgctgctatt gcggctaacg atgaaaacca 22200
ccctgatcac gataagtacg ccaatattaa gttcttgccg gaaatcagca aagatattgt 22260
caacgttcgc agggttcttg gtgcttaact ttagcttacc agtatatgct ttaagggctt 22320
atgatgtact cttccaaggg ggggagtaca ttgttatcca gacgagattt acaaggtatg 22380
tgctggacaa tccaagcctt cctgggacat tctctcagcg aaggcttttt ctttatggtg 22440
agcgggaaaa tttaccttac aagctctatc ccttaaagaa acagttcaag tacttatctc 22500
agataataaa ctctggacta aagcatttca tcgactccac aggtaagata gtaacatgga 22560
aacctacgac ttattacaac attatcacgg aacgcgttag aggatcaact agaatcttca 22620
acggaaagta ccagtgttat gttaagaacg taccataccc tttcttactt agtgaacctg 22680
ccaactatat ttcgtacgcg ttggttcgcg gttcaccagt tatttttgac acgcacgaag 22740
aggagccaga aactcctaga cttagagtta agatatgaag atagttatat ctaataaaat 22800
ctattgtaaa cccagcaacg aactgtggga atacttatta aaacacactt cataccagat 22860
ctttaaacct ggggcgaagt atcctctaat gttccagaac tcaggatcgg taggtaaaga 22920
aatcaagtgg ttccctgtaa cccgattaga tctcctagaa tctttcgggc aaaaagtgac 22980
agaggtcgtg gataaacgta ctctggttcc tgtggatatt ccaaagccat cgtttaccct 23040
gagacccggg gatcagctcc ctatatatga agactgtaat gatacgtgca ttattaatgg 23100
taagccgggg ttcggtaaaa caatccttgc tcttgctatc gcccataaac ttgggcaaaa 23160
aacgttagtt atatgtacca acactaccat tcgagctatg tgggagaagg aggtacgcaa 23220
gttcttcggg attgagccag gagttattgg gtctggcaaa tttaatatcg attctcccat 23280
cgttattagt aatatacaga cagttaacaa acacggagcc gctttggcaa aagaattcgg 23340
caccgttatt gttgacgaag tgcatcactg tgttgccacc acgttcacca agtttctaga 23400
gcagtcctcg gcacgatata aaatcgggct atccggtacg ttaaaacgta aggatgggct 23460
acaggttatg tttaaggact attttggaac gaaagtgtat agtcctccgg taaataacac 23520
tctgccacct actatccata ggtttgcgct aaaaacgcag gtttctggaa atatgaatgt 23580
gccgtgggcg ataagagcta acgatgtgta ttcgcagcca gagtactttc aacaggttgt 23640
tgacttgtgc gaattatatt caatggcagg tcataaagtc ctatttgtgt ccgatcgtat 23700
agatctgatt gagagagtta cgaacgcttt ggaactcagg ggtgtgaaga cctacacgat 23760
taccggtgta acatcgctcg atgataggga gcaagtacag attgacgtga ccaatgacgg 23820
tccgtgtgta ttagcggctt cccaaagcat cttctcggag ggtgtgtcat taaatgcttt 23880
atcgtgttta gtgttaggct ctttaataaa taacgaatct ctaatcgaac agttggcagg 23940
ccgtgtccaa cgtatggcag atgataagtt agacccaatc ctcgtggatc tgaagctagg 24000
aggtgtagga ttcaagcagg cggcaggtag agaagcggta tatcgtctca atgggtggga 24060
agttcttgac tttaacgaga agaacatggt aaacttagat aaaattctgt ttgctaagaa 24120
ccccaaagtt tgatataata tttatattga attgagagac agatttacaa agaagagtta 24180
agcaaatagt taaaaatttc agttgctgag tcctcaaaaa tacgatataa tatctgtata 24240
aattaatggg aacagcaact gaatcttcgg aaagtccgaa gcagaaaaat aaaaaactta 24300
gttgctaaat tctctcaaaa tggtgtataa taatcatgtt gttttatgat tacgaaaaaa 24360
tttacatatt agcgcgaggt aactcatcgc tgattgtaca gattatcaga cgaatggttg 24420
aagatcccga agctcatgtg atgttaacgg gtagatcatt tatcttgaac gaagatacaa 24480
tcgtttataa taaacgaaag ctgtcagacc gacagttggc tgagtatcta ggacttttga 24540
gttttagaaa ctatgccgaa tatagcttct caaaggatac atcactggat atgcaatata 24600
ttcctccgtg ggttcctaga gcagttatcg agcaccaccc actaatcgca atcaacaagt 24660
caaaattgac atttatcgag gaaaaataaa tatggctact aaatcttggg gttctactac 24720
tggcggttct aacggcgaca aactggacta catgaagttc aacaacggta agaacgttgt 24780
acgtatcgtt tccggcgttc tcccgcgtta tgtgtactgg attcagaaca aagaaggtaa 24840
accggctccg ttcgagtgcc tgcgtttcga ccgtgagaaa gagcgtttca tccgtggagc 24900
atccgatccg gttcacgaca tgggcttcaa agatccggag aagaaagatg gtaaggctca 24960
gccgctgcgt cctaagaaaa actacctggc cgttgttatc gatcgtactg ataacaaact 25020
gaagctgatg gaagttaagg caaccatcct gaccggtatc cactccatca tggcccagct 25080
gaatctggaa gatccgggtg agatcgatat cactatctcc aaatctggta ctggtttcga 25140
tactaagtac gatgtacagc agatcgcagc tatgcagttc cagatggcta aaaatcagcc 25200
gggttctaaa gaggccgccc tgcatgaagc cgacgttgct ttgattggcg aggctctgta 25260
caacgaagcg gacgaattcg aaggcttcga aaaagtgcct aaactggatg ttacctaccc 25320
ggttccgtcc tatgacgagc agaagaaagc aatccaggca tggctggaag gtaagaaaga 25380
tgaggagggc gatgaatcta aaggtaatga aggttccgca aactccggta acatcgatca 25440
cgaagcagct tctgacctcg attaatccaa acaaggggag cttcggctcc cttttatttt 25500
gactatgaaa aacaagttat ttgagatgta ttctacttgt ccagaggatt tcgaacgatt 25560
cgtagcagct ttacgagaga cctataggta tgatcccacc actggtgtta tgtctagact 25620
aaagtcctcc ggaggcgcta gagctggctc aactgttgga tctgataatg gtaaaggcta 25680
tttacgctgc tcgttccaac gatcgttata cttagtgcat atcttgatat acgcactagt 25740
aacaggagaa atggtcgaga ctatagacca tcgcgactta gataagaaga ataatgcttg 25800
ggataacctg aggcccacca ataagtcagg taacgaaaag aatactaccc accgtgtaac 25860
atctaccaca ggtgttaaaa atgtgtattg gattgatgaa cgaaataaat tcagagtcca 25920
atttaaggta gaaggtaaaa caaaaacctt cggttactac accacgttgg aagaggccgc 25980
gcaagttgcg aagtccaaga gattggaact tcatggagag tttgctagat catgaaaatc 26040
cttttttcag cagatactca cattaagcta ggacagaaaa atgtacctag tgcctggcaa 26100
gagaatcgct tccttatgct aggagaacgt ttagataata tcttcggggc aaccggttgt 26160
gatcttcaca ttatcggtgg cgacctaatg gacgttgcag atccttcgtc tgaagaagtt 26220
gagctaatgt ttgccttcct agcaaaatta ggtcatccag gtattatcta cacaggtaat 26280
cacgaactta aaaccaagac tatttcctgc ctggatcact atgccgcagc catccacgat 26340
gctactaacg gactttggaa agtcgtcaaa gactacagat ctccagagtt cgatatcatc 26400
ccttacagca gccttcacaa agctagttgg aagcccagag tttcagacat ttgcttcacg 26460
catgtcagag gtgcaatccc gcctcatgtc gtaccagaaa tcgacctcga aagattcgtc 26520
gaacatgggt actccaaagt atttgcaggc gatctccaca gctacaagaa cagccaaaag 26580
atcggggacg ttgacctgct ctaccccgga tctccgctta caacttcgtt tcacagagaa 26640
aggacaaaag gaactaacgg agcttttatc atcgatacgg tcttgccaag agaccatgag 26700
cactaccttt cgtgggttga actgggagat cttccacagc tcatacgaaa aactattgaa 26760
gtcggcgagc caatggaagc cgatgcgtat gacagagtta tatacgaagt caccggcgac 26820
gtatcacaac tcaaaacgtt aaagaacagc gaactgttag ataagaagat caataaccgt 26880
gtcaccaaag atgctaagtt agatctagac gatatgtcac tgctacagga gctggatact 26940
tattttacaa acgtgcagaa actagacgaa gcgtctagaa ctcgcatatt aaagagagcc 27000
gctgagtatg tcgatagtaa ttaataaatt gacaatcagc cattttatgt cgtatgctga 27060
gaacgtggtg atcgagtttg ataatcaccg cgtaactcag ttaatcgggc gtaatgggct 27120
gggtaaatca acaattggta cagctctaga agagcttctt tataataaga actcacgcgg 27180
tatcaaaaag gacgacctgt ttaactggca tactggctcc aagtcctata cgctagaagg 27240
tcagttcacg aaagacggtg acgtgtataa cgtcaagaaa gttgtgaagt caaccgccaa 27300
agtaactctc actaaaaacg gtgaagatat cagcggacac accgcaaccc aaacgtataa 27360
gctgatagaa gaggtactcg cctgtgattt tacgacattt actaagctcg tatatcagtc 27420
agttggatcc agtctcgact tcctcaagac tacggatgct cagcgcaagg ctttcctcgt 27480
taacctgttc gaccaggaac aatataagga agtttctgaa cgtgttaaag cgggacgtaa 27540
agccgtctcg gcaaaactgt ccggattgga aggtagcctg cgaactgccc aatctatact 27600
ttcctcaaaa gcctcgcttg gcacacctca atcagagatc ccaatccctg ttttcgatga 27660
agagccacta gtcgaagaat taaccgaagc aaaagtcaag gtagcactgg ctcagaagca 27720
aaaagccagt attgcaaaac gtagctcttt ggacatggcc gtacaagctg ccgaaaaaac 27780
ttttgcacca ttcgaaaatt tacctgcgcc cacctcgaaa tctgaggaac tcctgagtgt 27840
tacgcgtaac ctaacggtcg tggcaactag agcggatgat ttgaagaaac gttactacga 27900
tttcaaaaat gcagcaggta aaactcagtg ttctgcgtgc ggaacccact tagacacctc 27960
cgccgctcaa gaggccatga gacgaactaa ggaggagtat gatccgctgt ataaagaacg 28020
tcaaaagctg gaagcagaag ttgaagaact taggaaggaa gatagggcgt ttaaggatta 28080
tatctctaag tttaacgctc tggaacaggc tcgcaaaaac ctcaaggaat ttgatgaggt 28140
caatggaacg caggatgaaa tcgtagatgc tagtggacta gctgaacgta tcaaagctat 28200
tgagtctagc attcgtcaag gcagatcttc ggtagaactt gcaagaaccc ataacgaatc 28260
agttgtacgt gaaaacgcga agtatgaagc taagcgtgaa cagattcaaa aggccgagca 28320
ggagtttgat aagattcaag ccgagttgtc cttagttgca gaagaagtag cggatctgga 28380
tatcttaatc accgggctga aagatctggt agggtataag ctagagcaca gcgtcaaggt 28440
atttgaagag atgatcaacc actatctctc tatcatgacc agcggtaaat ttgctctagg 28500
gtttgagttg gacgagacga agctacaggt tgtcatctac aatgatggta acagaacttc 28560
tatggtcaac tgctcaacag gtcagcagag ccgcatcaat atctccacgc tattagcaat 28620
tcgaatgttg ctttcaacaa ttagtaaggt taatatcaat ctgctcttcc ttgatgaagt 28680
tgtaagctat attgacccgg atggaattaa taccctcgta gaacttctac aggaagaaga 28740
tcagctgaat tcaatcatcg tatctcacgg gcatacgcat ccgtacgcac ataagattga 28800
ggttaaacaa gacgaagctg gcttatcaat tttggaggcc taatggccgt agatagtcgc 28860
gagaaaggaa aacgcgcgga ataccaaatc cgtgatatgc tgcgtaagta tacctccttg 28920
gactgggaac gtgttcctgg ttcaggagct tttggacagt cccactccct gaagggtgat 28980
gtgtatttac cacctagtgt aggtaaaatg agccaatact gttttgagat caaacactac 29040
gcagacgaga aatttaatag caatatccta aacgttggag aatcccaact agaaaaatgg 29100
tgggcccaag ccgcacgtga aggtgagcaa atgaacatga aacccgccct gatctttaag 29160
aaagatcgtg gtcaatggct tatcgctctg gatagtagcg accctatgat tgataacctc 29220
atgagtagag cacatttcat agtgaataaa cgtggaatgg aaattgttat cggtcttttt 29280
gagccgtggt taaacgcatg tgatatcgga gatttagtta aatgagtaaa tcctggggaa 29340
caatgaaacg tgaggcagaa caacgcctcg cctcacgccg taatcttatg attgttgacg 29400
gtacgaactt gggcttccgc ttcaagaaag atagtggcaa gcctattgca gcatcctttg 29460
caaacaccat caactctttg gcaaactcct atgacgcgaa gcatactatc gttctaggag 29520
ataaagggaa gagtatcttc cgtactaata ttttcccgga gtataaaggc aaccgagatg 29580
cgaaatacgc cgatcgctcc gaagcagaag tagaagcgga tcgccagttc ttcgagtact 29640
tagacgatgc gtttgatctt atcgcaagtc aattccctac tttccgaatc cgaggggtag 29700
aagcagatga tatggcggct ttcattattc aactgatagg ccaccactat gaccatatct 29760
ggctaatctc cacagacggt gactgggaca ctctgttagc tccgaatatc tcacgcttct 29820
cgtttactac tcgtaaagaa taccacgaga aagatatgtt cgacaaccat aacgtagaca 29880
ctgtggacca gttcatctca ttaaaagcca ttatgggcga tatgggtgat aatatccgag 29940
gtgtggaagg tatcggtgaa aaacgtggat acaatctaat ccgggaacat ggtagcgtgc 30000
tagatattat tgatgcgctg ccgctgccag gaactcaaaa attcgttcaa gcgctgaata 30060
aatcaggcga actcatggaa cgtaacctaa ccctagtaga tctcccaagt ttctgtggag 30120
aagcagttgc tgcagcagga caagatatct acgaccaatt tgttaaagac attatggctg 30180
ttgccacagg agaagtataa tgcgtattaa attatctcac cccgattgta aacctcacgt 30240
tggaagttcg gaagcagctg gtatggatct acgggcctac ttcggagatc gtgcttcaga 30300
cctactacgt gccatacctc ccggggagtc attgatgatt gataccggag ttgcggttga 30360
gatccccgaa ggctgggtag gaattgtggt tccgagaagt tctctaggga aacgtcggtt 30420
aatgattgcc aatacagtgg gggtgattga ctcggattac cgaggaacca tccagatgaa 30480
tctgttgaat atgagcaatg agactcagcc aattgataac ttcgagcgtc tgtgtcagtt 30540
ggtgatcgta ccccattata atcccaacga cattgaaatt gttgatagtc tgaccgacac 30600
tgatcgtggc gaaggtggct tcggaagttc tggtaagatg taaatagaaa aaccccagtc 30660
ggagcaatcc gctggggttt tgttttattc cactcctggg tcttctggca tttctacttc 30720
tggaatctcc acttttggca tttccagacg caggtcaatc caacgacctt ggggtatctc 30780
cataggttca ccagcgatga tattccctgt gttaatatca aatttacgag tgaacacctg 30840
tatgtttagc tccttctctt cttcattcca atccgattcc acgaagcaca acatattacc 30900
gttgtcatct cttggtaatt cgaatttcca gccttccgtg ttccagccta aactcccttt 30960
aatcgtatac ctgcctagtc cagtttttac agcaaataca ccttgagcct ctgcgttaca 31020
ccctacgtag cctcctacag tttccacacc tgtccagaag aacgaatcct ctttgctagg 31080
aatttctgcg atgagcttgg cgatagggga ggctttcttg acaaaaccgt taccgtctat 31140
agtaatacct gctataccgg actgaatatt aggcttgtta ccttcatggt atagggcaaa 31200
ccaaggtctt ggactagttc ctgagtctgc tctcagtgag cgaacaaata ccccaagtga 31260
cgtaccgccg ttccccgtgt tggaatcgaa gaatatctga gataaacggt attgagactg 31320
acgaaacgta gctatagtac ctaagcgtcc agtagtatta ccaggagtat ttttggttcc 31380
ggcgccagct tgttgtaatt gaacacctct accccactgg tcatttccgt ccgcggtatt 31440
attgacatct aaatctgcca aggcttcgga agtaacacca gcctcaggtg ctctagagct 31500
gatcaagttt ataactgtgt ccctacgagt cagaacattg ggctcatcaa cgtttgcggc 31560
ggtttgcttt aggttaccat cagatcgcat ttgtatttct gtagtagtag cactatcccc 31620
gttgggccta aaagctaaga accccgtagt ctgtccgcta ccattgttcc ctgaaataac 31680
cattgtgccg gtatcattag ctcgtatcct ggcgccaccc tgccatgaaa gaatatggtt 31740
cttagttgct gtgagaggga agactagatt accgttcgga gcaatttcta ctgaggccac 31800
agtatcttca gtacctgcag gacgtaggta aatagatctg ttattcagtg aaattattcc 31860
tccagtaggc cttgctgtaa gcgtaagata ctcacttcca gaatcaccgg ttactcgtaa 31920
agccttgagt ttagccaggc taatgccatc atcaatcacc tgcgccctat ttacatagat 31980
aacatcagta tcaaaacctg tagttctcca cgcaggggct gttccgtcca ctaaaggtcc 32040
agtaggtgga gtaacagata tggaaccaga taaaaatgcc atcttagggt ctctgaaact 32100
actacgagat ttgaggtata catcgtaagt tacgttgcta ccctctatag tggacttaag 32160
ccccaccata aatccattcg tgttggccgg acctattact cgatgactaa ggaagctgcc 32220
gatgttatcc gcagttacag aggttacagg accaggtagc gccagggata ctatctccat 32280
attgtatatg tcatccctgt tggctccatt acctgtagcg tagagcgcaa acaatacgtg 32340
aacgctggaa gactgatttg cggctattgt tatggacgca atcttagctt ctgccgagcc 32400
ggtcatcact cctagtggtg ttaccaggga cgttttacct gccaaattct gagctacctg 32460
ggcggatgct gccgcattag tttctgaagt cttagctgct gtctgggaat ttttactagc 32520
ggtttcagaa gccttagcat tggtttccga agttttagca gcagcggcgg atgctgccga 32580
tttagtagca gcatctagta attctgtagc agccagggaa ctaactgagt agcctagctg 32640
tacggtaaat tttgggtatt tacttaccct tgagttagct ccgtcaaggg cagtaacctg 32700
ttgtgcaata attcttgttg taatagccat tacgcggtta ctccgtcact gacgtacacg 32760
ctcccttcca taactctata agaggtagcg gtagctcctg ttcctctggt catgattaca 32820
tcatagtaac ctgcgaaccg aagtctagga ttatatttat ctcgttcttt acttgctttg 32880
ttaacgattg ttgtcacagt agccgctgtc aatcctagcg acgcctgacc ttgtgtagca 32940
tttactactg ttacgacgaa atctgctaat tttaccccag tggattccaa agagtcttta 33000
attgaagact taagggttac ccctgtcaga ttgacagggg tttccgttgc tgggtaagca 33060
gagtcatcga tatccatgaa ctgtagcatc agtccgtatg atacattttg atcaaggata 33120
atatcaacta ctctgttttc cgtgctcatt tgttacctta tatgaatgta cccgttagcc 33180
aggtctattt tcattgtgta cgtaccttcc gggttagaac tcagtgcggc agccctattg 33240
tataggatgt caacaccaat ttgcgccagg aacgcgttat ttgcaataat cttatccgca 33300
gtgatagagc cagaaacgat catatcaccg tgaacagtta gtgcaggagc tgtccatgct 33360
gagccattcc attgacgagt ccaggagttc tggggggaac ctgacttata ctgagtcagt 33420
acatcatact taactggcgg tccagcgaag gttgactgga agaacgatgc tgcttgagtg 33480
tcattccatg cagtcaggtt tgatatcggc tgggtgtaga accccggccc acgatcccct 33540
acggcgtcat actggttacg gacatatgac gttacgaagg ctcccttttc aatcttacac 33600
cttcctacaa cgttatttcc ctcagattgg ttaactgaga atctaacgga tatcctatct 33660
gaattagccg gcgtagtgaa ggtaaagctg ctcaaacctg cagtagtaga cgcaatagtc 33720
ttcagcactc ctccagtggt attgcttccc ttagcgtacc agaatacgtg acaacgaact 33780
tctacagcgt tatcagtctc gaaagacatc gtatatgtgg tgtttggagg aaggtaggtg 33840
aacatggagg cgggtccatc tgatgggagg gtatacgcat cggtaactcc tgtacctgca 33900
attatcctag cccttagtaa ctcatagttc ttacctatag atgagccatt accagcaact 33960
ccggtaattg agtctaacca agctttaaag tagaacaggt tctcgttaat actatccccg 34020
tctaggcgaa taggatctga ccaattacct ataatagcat tagtttctcc gttaaactcg 34080
gccttaacca tccatagagg gctacctgga ggagggctat ctgaccagcc agccggatta 34140
ctaccagaag gcctactagg agtgctagcc attacggcga acttcatact cacatagtta 34200
cctttagaac ctggcgtacc attagcccca ttctccccta ctgctctgat cgctgggccc 34260
caggatccgt tcacctgttg gcgcatatac agatcacctg aagtaaacgt actgtgccag 34320
ttagtagaac cgtccttaga ccactggacg tttacagaat taccagcagg accttgtgga 34380
ccttgaggac cggtatcccc tttgttaccc tgaggacctg tagcaccagt gttaccttga 34440
ggaccttgag gaccagtagc tccatctgcc ccatccatag acagatcttc aatagctata 34500
gctgctacat aagcgttacc aaaaggtgag gcactaccat tcatctggat aaatggtctt 34560
gccctaccgg tctcggttga ccctccatcc gttaccgtta caataccgct tactagcttc 34620
catccgtcag gatctttagc tggcgcagca aacgcagtag gccacgcagt attgacactg 34680
ccattcgcgt tctgacaatg taaaccaagg cgtagctgat actcaccctc agagttgttc 34740
acccatgcag taatgcggta gcgcattcct ttgcgagtag ggaaccagtt attagcctcc 34800
atagtgtccc tagaagcaca cactatagct ttagtatgtc cccccggttg tccgttggca 34860
atatccacca catcacgacc ccacgaccct ctgttacccg agtcaaagga ccccgtgaac 34920
actctgtcgt aaccaatccc aggcaggctc ttcttgagcg taaacctctt aataagtgtt 34980
ccatacttag gatgtgtagc tttatagtcc acccacccag aggtaatttc catcccgtta 35040
ggcatattgc taggagcata ataaccgctt gaacctatgt tgccgttaag attgctctta 35100
tcctccaccc caaaggtaca ctggctagta acgtctactg ttccatagaa cactttgaag 35160
ttaccagtgg tgccgtccca gttctgcaca aaaccgtagg agttacagga caagttcgcc 35220
gcttcgttag ttaggtatcc gactagggag tttatcccgt cttgaagtct aactattgta 35280
atagaatcag atattccgtc acacgttgcg gttactgtta cgtactccga gctcccaaac 35340
tgagcagaag ttatagtctt gttagtggcg gtgccaccta aagttatatt accccccgcc 35400
tggttcttag cagtccaggt tattgcagca gtggtattct gtctccagct atctatctta 35460
atagtaccgt tagacttcaa gttaccacta gtatcgaagc taaatgacag gctatcggat 35520
gttagagcaa aggctttagc attactaccg ttagcccctt gtggcccttg tggtccagta 35580
gcccctgtgt cccctttgtc ccctttgtta ccctgaggac cttgtggacc ttgtgaacca 35640
tcggcaccaa tagtatccag ttcatttcta atgaacgctg tagcgaagtc tccctcttcc 35700
agcttgatat tggaaacaac gttggttcca cctgggttgt tgttcagtga cacacggaca 35760
gataccctat cacatcctgc aggaacagtg aacgaccagc tagttctgcc agcagttgtt 35820
gacgctatcc aagagaatga tgaggtagta gtatttgctc ctgcctggat aaagaacacg 35880
tgcattctca tctccagagc actatccgtg tcgaacgaca tagtgtagcg cttacctgcg 35940
gtaactttag tgaagaacgt accatcacca ccactaggca tggtatatgc gtcagttgca 36000
ccagaacctg cagtaatgcg taagcgtagt tcgtcagggt ttttagctac aacagatcca 36060
ctaccactgg cacccgttat agacgcaatc catgctttgt tagcaaacaa gttgaggttg 36120
accgtctcac cgtccagacg aactggatct gaccaggttc cctgaagttg gttgctggag 36180
tcaaactcac ctttaaccat ccagagtgga gaaccttctg gaggcgaatc agaccagtta 36240
gccggagagt tcccggtagg tctagcaggt ttagttgcag ctacttggaa tctcagggag 36300
gtatatttac catcagcacc aacccgccca tcctcgccaa ctgcgcggat tgcagaagac 36360
cacacaccgt taacttgctg acgcatataa atgtcgccag tagtatagtt tgtgtgccaa 36420
tcgctcgcgt tgccggtttt agaccactga actcctactg aagcacctgc tggaccttgt 36480
ggtccctgtg gacccgtatc ccctttgtta ccttgcggac ctgtagcacc agtgttacct 36540
tgtggacctt gcggtcctgt agctccatcc gccccgtcca tggataggtc ttcgaagtgt 36600
atgccagcaa caagcatata ccctaatgaa gcgcccgagg ttttgttatc taactggaac 36660
cacggccatg caataccttc gtcattaaca cttagggtca actcttgatc gaagtatgcc 36720
caggaactat ttgatgctgg tccggtaagc acggttcttg aaggatatcc tctattacca 36780
tccttacgat gaacgataaa ccctactcta aagtgggctt cctccagtcc tattgggttg 36840
taccagaatc tgatacggac tttttgccca cctactactg gaatagtatt tctaccttct 36900
aggttatctc tagctgtgat gcgtaacgct ttagagatac cctggttggt tggaccggaa 36960
acaccctgta gagttcctgc ccacgagcct ttgttaccat tctcgaaggt attggtgata 37020
accatctcgt agctcttggc caagaatacc ttagttaccg caaaacgctt ggtaattgcc 37080
ccgtatttag gatgagtagc cttaacatcc acccaacctt cggtaacatc agttccgtcc 37140
gacataccag taacagagta gttcccattt gaagagttga tgctaggagt tacgttactt 37200
cttccacctt cagagaaagt gcactgacca gtaacatcgg tgcttccgta ccaaactctc 37260
atctgacctt tggcgttttc gtagctctgg caatatccgg agtagttagc aagtaccgta 37320
gctgcctcat tcgtcataac agcagttaat acgttctcac cgtcctgcaa acgaaccaca 37380
gtaatctggt cagataaacc atcgcaggtt gctgttactg taacccactt agaagtgccg 37440
aagttcgcag cggttagctg acggttatct ccggagttca tcagtgttac tgcagctccc 37500
ttatcgttta cagcactcca cgtgatccct gcagtggtat tctgttttaa tcccttgaac 37560
agaacagtag cggcagactt aatatccccc acagtgtcgt atacgaatga ctggtagtct 37620
gacgttaggg cgaagccttt agcattctct cccgcgttac ctttcggacc ttgtggacct 37680
tgtggacccg tagcaccagt atcccctttg ttaccctgtg gaccctggga gcctgtagca 37740
ccagtgtttc cttggggacc ttgcggacca gtagcaccgg tagccccatc cttccctcta 37800
gcgtcaaact cattaagaat ccacgcagta gggaaagcgc ctaactccac cttagcccga 37860
cttatgacgt tggttccgcc tgccgcattt acagagaatc tcagcgagat atagtctgta 37920
ttagcccctg tggtaatagt tagggagtgt ctccctgcct tgttagtctc caggtaatta 37980
tttctaacaa aggagttacc atctccatta tcaaactgaa gtacaaacaa ccgagcttta 38040
gtagcttcgt ccacttccca ggaaatcgta tacatagtgc tcttctgaac aggtatgaag 38100
tacgttccag ggccaaagta cggttgagta tacgcatcag tttcggcagc cccagcagtc 38160
actctgaatc ttagctgatc gtagttttta ctaatcgagg aaccgtttcc tttcgcactc 38220
tggatagagg ccatccactc tttaagtgac cagaagttct cacctacccc ggaggcatcg 38280
attcgtacag ggtcagacca agtaccaatg atagcgttag tatccccgtt aaacgttgct 38340
gttgccatcc aaagaggaga accgtcaggt ggagcatcaa accaatccgt aggtttatta 38400
cctgtaggtt tagcaggttt agtatccgaa atacggaaga tgatattggt gtagttacct 38460
ttcttaccat caggtccaat ttcacctttc tcaccgatag cacgaatcgc aggaccccaa 38520
acaccatcaa cgttctgacg catgaacagg tcgccggttt ggaagttatc gtgccagtta 38580
ctagcagagc tatccttaga ccactgaact agaactgatt tacctaccag gccgatacta 38640
tctgagtatt ctacctgata atcagtcttc tccccaccct cttccagttt gattttactc 38700
cacgtggttt ctacgttgag agtaagaatc gaagggcgta gggttaagta gttaatacct 38760
gccggaacta caaaagtgcg cttaacctta atcgatgttc cggtgttaag ttcttctatg 38820
aacgtggact gcggtgagtt cggagcagcc tgccagaaaa taatatctct ggtttggact 38880
tcgctcgccg catcaatatt gtaggttaga gtgtaacgct tacccggagt taccggatga 38940
gagaaggcac ttgcaccaac aaaaggagtc gcataacatc caggggatgc gttattagtt 39000
ccagaagtac gggtcagaga atgagttagc ttctcaatgt cgttctttga tgtaccagag 39060
tccgtaccag tcagcaatgc catccatttg cgaactgcga acaagttagg gttgatagta 39120
ccatccagac gaattgggtt agaccatgtg ccttgcagct gaccactagc gttcatcgta 39180
cctttagtca tccatagagg actaccaaca ggaggagcat cactccagct acctggactg 39240
ttaccagtag gtgtgccagg tttagtatct tgaacgataa acttcattga aatgtagtca 39300
ccgtcagtac catcttcgcc aactgcacga atagcaccgc cccaaactcc attaacctgc 39360
tgacgcatga aaatgtctcc agtttggaaa ccagcatgcc agttagtaga cccgtcctta 39420
gaccattgaa cgtttacaga gttaccagcc ggtccttgag caccagttgc accagtatca 39480
cccttgtccc ctttactacc ctgtggcccc tgcggacctg tagcaccagt attaccctga 39540
ggaccctgag cacctgttgc accatcggcc ccgtccattt ctagggcgaa catatgaata 39600
tccgtgatga aggcttcacc aaagttggta ttagtggcga tctgaataaa tggtctggct 39660
aaaccagtat gatttattac tactacagct tctgtgtagc cccacccagg ctcccctttc 39720
ctacggagga gtgcggtagg atagtccata gctccagtat cgctacgctt catgtggacg 39780
ccgatacgaa gatcagcacc aacgtttact gtattcgccc acccagcaat tttgaacttc 39840
tgacctttaa ctactggaaa gtagttagcc tcctccagag tatcgcggtt agaaactcta 39900
agtgccttag aaaacccagc agagataacc tcaacatcag tagaagcaat atctacgagc 39960
tgacctccag caccccacga gcctttactt ccattctcga aagaggtagt gatgatgcga 40020
tcataacctt ttgcaaggat agatttagta gttgccactc tgcgaaccac agcaccgtaa 40080
gtagggtgta ctgcacgtaa gtcaacccag ccgttgataa catcagtacc agccggcatg 40140
ccttttaagg tgtacttacc agcagcgttg atatccgcat cgaggttgtt cttctccata 40200
gtactgaagg tacattctgc agtgatctcc cgcgccccgt agaacacttt aaaatcacca 40260
gaaccagtac tgtagttttg gacataacca gcatagttcg aaagaacggt ggaaccctca 40320
ttagtcagga gccctactag agcattggaa ccgtcatcca gacgaacaat agtgatctga 40380
tccgtgattc catcacaaac ggctgtgact actacagact tcgatgtttt gaagttggca 40440
gcagtaaggg aagcccccga gttgctaaca ctagtcaggg taatattccc ccctttctcg 40500
tctctagcac tccatgttat gttagccgta gtgttctggc ggaaagcctg gaacaagata 40560
gttgcttcag atttcagctt accttctgca tcataggtga atgtctggcc tagagaggag 40620
atgctgaacc cttttgcatt atctcccttg gcaccttgtg ggccttggtt cccttgaacc 40680
ccctgtgggc cttgagcacc agttgcacca gtagcaccag ttgcgccctc ttcaccgata 40740
gtatcgaact cattacggat gaaggcggta gggaatactc cctcttcaag ttttaactta 40800
ccaatggtgt tctctttacc ggcttcgttc acagagaatc gtaatgagac tctgtctact 40860
cccgcaggga ctgcaaaagt atgagtagta aggcctggag taagcgaaga cgtattagtg 40920
aaaatactcg aagagttagc ccctgctttg attaaaaaca ggtgagtcct aacctctaca 40980
gcagtgtctg tctcaaagga gaaagtgtac tttttaccag tagtaactgg tatgaagtac 41040
gttccatttc cacctgaagg cacggtatac gcatcattgg tggaccctgc aacgattttt 41100
aacctcaaat cggtagggtt cttaacgata gaagccccgt taccattagt acctgtcaaa 41160
gatgctaacc actttttagt agacagtaag ttttgattaa ccgtatcacc atctatacga 41220
accggctctg accatgtacc tactagggca ttagtttgac cgttgaactc ggctttagcc 41280
atccataggg ggctaccctg cggaggtgcg tctgaccaac ctgaaggagt ctgacctgta 41340
ggagtagcag gtttctcatc agccacgcgg aatcgcagtc caatgtagtt acctttagac 41400
cccggagtac cattagtacc atcttccccg actgcacgga tcgctgaact ccagccaccg 41460
gtaccaacac gctgacgcat gaagatatca ccagtagtaa agtttgcatg ccagttagta 41520
gtaccatctt tagaccactg tacttctact gaaccacctg ccggaccttg aggaccttga 41580
ggaccagtag caccagtagc accagtagcc cctttctcgc cgtctactct gatcgggtct 41640
gaccaaccct caacagttag agcgttagta tcgccattga atctaccaga acacatccaa 41700
agaggggttc cagtcggtgg ggtacgactc caaccactag ggtcattgat attgcctggt 41760
ttcgtgggct tactagcact gatctggtaa atctgaacag tgtaatcacc gttagaacca 41820
tcagtaccac cagtacctgg gacaccagac cactgggatg cagctgagta gttggtaccg 41880
tctactagag caggaggact cttcttagga tccagagtac cctgcacaac gtacacgttc 41940
tgattctgag cagtgcggtt aggcgggaat gcggaccatc cagctggtgg ataaacttgg 42000
tcaagcgggc gacttggcag agatgtacca agtttataag caaatatagt ctgcttaccc 42060
tgcataccgg tttcaaggtc tacatcgcct ccaggagtac cgattacaac gttaccagaa 42120
atgcgaagag tatcaccgtc ccagcgcaca tactgagtgt tattaccgag gtcaaatttg 42180
gccttaccgt caacgttgtc aacacccatc cagacaccac ctgcgttatt accgtacttc 42240
ttaccctgag tgaagattgc cgggttatct ttaccggtca ggttagtaag aattacgtta 42300
gcagcattaa tatctttagt gataacttta ccatcgacgt ttacaatctt attaacaggg 42360
tcgaatgaaa tcggcgcttt accattttca tcgagtgtac caagaactac tgcacctgta 42420
gcagcatcga ctaagaaagt ctgctcccac tgtttggtgt tagagttcca aagtttaccc 42480
ttgatacctg cgtaggtcat ctctacaccg gtctcgttaa tgaatgcatt gtcgaaagtg 42540
gtgctctcgt ctataatata agtaacctcg ttagagttag ttatagactg agtatctggg 42600
ccccaagcaa ccgatagtac acggaagcgg tggcggattt tgtaagggaa gctagtgata 42660
gtaccagctt tagctgcacc cacgtttagc ttgttggcct tagtccatcc agtttttgca 42720
aactcatcgt tactaatata ctggatgata aattcacgaa cgttagcacc tgtaccacga 42780
gtccaatccc attccaggcg aacgtcaaaa cgctccatac catcttggat gtgggcggtt 42840
ttgaaacgca ggttagttgg ggcagacggt ggagtgaagt tgtaggtcag gttaaacagt 42900
gatggccagg tatcataccc agaaacatcc acagtaacac cgtctggcat agtgacaaca 42960
ccagataccc ggatattgta tctgccaact ggaacaccac caaagatgat ctgctcagtg 43020
attggaccac ggtagtactt agtccaggtg ctagagccct caggtttcat ttcgatggta 43080
acgtattcgg cctcaccaga aagctctacg acaaccatag gagcacccac acccacgtca 43140
acagattctg caaaagagga cactttggta atcttcggag cagttttcat cttgaagtta 43200
acggtgctag agaggttcat acctacttta gcagccatca gctctgcatc aaccatcgag 43260
tcatagaaag caccctgggc agagtaggta gcgccagcga ttagattgtt aattgtggca 43320
atgaatgtat caacgccggt aaagtcccta cgggtggtta ccccacccgt agttagccag 43380
aaagttctac caattacgtc gtaatcggaa aagattgagt gctgaatact cgcaatcgta 43440
tagccggtca cgatattctg cagtaccatt ttagctggtg ctatgtttga aatcatttag 43500
atatatgccc atgcaaccga cttctcgccc tttggtccct ccgcctgaat tcttggctga 43560
agtgctctgt aaatccccaa agtattcgag ttgttggcct tgtagtcgag cttattgtag 43620
cccaacaggt agctatagtt atataaactg gtgatcttcg cggatctaag cagtttatta 43680
gtgttgtccc ttatttcaag cgtgtagaaa atccctgaaa tcagcccctc ttcttgcagc 43740
ttatcccatc ctaactctaa gtcaggtcct acccattcag cagggtcagg agcaaggtta 43800
agcacccgga agttttccac catactaagg ttcttagctg agttcaaatc tacagaaatt 43860
gttactggag agctacgacg accgttaata tcaacggcgc ggatctcgaa aatagtcagg 43920
ccagcaggct cacccacgat atcttggaac attctaacgt taggtgtgaa agcagtctgc 43980
tgcacaatat aaggatccac acggtccgat ttacgtattg agtaatagac tacgttaggt 44040
gtcaagctag gaagccatga aagctctccg tttttgccaa catcacctac cattccacca 44100
ggtgtggggg tgtacttaaa gtctcttgga ggcaggacgt tattggatat ttcaggaacg 44160
gcctcgctac tgttatccac ctgcgttgag ttaataaata catcctcacc atactcctga 44220
agagttacgt ttatcttacc atcccttgtg ttctccacct catctactag gaagaacttc 44280
ttattccagc cataacgatc gtaggtgaat actacaggat cgttaggttc tataccaagg 44340
aatttgtaag gtaaagagaa actcagagag cgagagtaac gagacttctt aagctctcta 44400
tctgccaagc ttctagcagt gtagtagttg gttatgttag caaaagaaag ttgaagtttc 44460
ttgtcaactc cacgatcttc attcttaaac ttagaattat agaacgttat agagttggtt 44520
ttccagttca gggtaggatc aatcagagat acctgaactg agttgtactt attacggcct 44580
gtagtatctg agagatccag gtccccataa gtatctagga aattaagttc tagcggagtt 44640
tttgaatctt tctctacggt gatgcggaag atacctgata ggttatttaa cgccccctgg 44700
aaggattcta atagctcctg cacgtttttg aacacagagt tggagttatc caggattgtg 44760
ttcatttgca ttatttgtct gttttcggct gtccagctct cccatccaac gtatctccag 44820
aaaggttgcc aactagtttg ataagaggtg tcgataatgt ttaatagatc agcctctttt 44880
ctccagtcac caatcaccat tctgtctatc gggatacttg caccaaaggt agtggaggtt 44940
aggtagtcaa atgtttgcca cacaccattc tgactcgttt tatccatttt aacagaacca 45000
tctgcccggt atactttcac tttgcgtccg cttaattctg cggatacttc aggaatatca 45060
gttctgttct ccgtgatagt gaaacgtatg acagcgtatg cggtgtctaa taacttgtat 45120
ctagaatccc agtactccgg accattaccg ttctctcctt gaaggaagaa gttgttagca 45180
gcagcaatgt ctcttagtac cgtagctacc gtttggtctg gcttgccatg gaatgtccag 45240
attcgtatat ctccattacc gtcattatac ttgtattctt gaccatgcgt ggagagagat 45300
gttgatggga gtcctgtgga aattcttgcc atagtatctc ccgacaccct tttttgtcca 45360
aagcatgtac gagaggtact gtcagtttga tcagtacaga tcataggggc gtccccaaac 45420
tggaagtcta ggaatccttc aatctcaccc tcacagaacg cgtaaactac atacacaacg 45480
ttcggattgt ttctttctgt atccgcgaaa accggaatac caggaacttt ttgagtacca 45540
tatactacag gaataaactt ggccgcaagg ttgaagtcca ggtctacttc tttagtaaca 45600
gtctcgtaat actttttaag gctgtagctc ttggagagac cgaataattt cttcttagat 45660
tctagcttgt atcgttcttc ttttacttga tatttagcta ggaagttaac gctcttgttg 45720
gcgtggaaga atccgtagtc ctcttgatat tccggtcgtt tggcaccgtg agaaggtagt 45780
aattctccat ttacaatctc aagtcctcgg tgggaagcgt cgtctgtgaa gcgtccagca 45840
actcgctcaa aatcgtagaa ttcgttagaa cagttccaag ttataacaga agtaccaact 45900
ccggatactg tattactttc tttaatacca ccacccacaa tcttacccct aaagaagagt 45960
aatgggccgt tagtatctgg gtccactgga aggatttccc cattgtcgtc gatgatcgcc 46020
tgatatatag aaatagagcg atctaaaaat gatacaccac tttgcacgag cttaatgact 46080
tcgttggcat ccgtaccagt aacactgaag ctcaaactgc cgacggttaa cgtacggttt 46140
tgtttgtgac tgctaattgt tttaattttc cctgattgga agagtatacc accatagttg 46200
atatctctca tatagtccgt catataagca taaacagcat tattacccgt ggaccccggg 46260
agttcgatag agacaagata cgctaatcgt atcttgtcat tgttggcaag gtaggctttc 46320
gcagaaggaa ggatctgtct catagacttt ctctcagaac taggttaacc ccgtcatata 46380
caccatcaac tgtgatctct tcgctgaatg aatctccgtt cattaattta gtttggaaaa 46440
gaatcccatt gaaacgtggt ctctcggagc cgttggtagt gagcaacaga tcagggtata 46500
gattaagtgt ccatactcct gctacgtttt taaaagatgt aatcttatac acctttggat 46560
gtgtggttaa ctggaataaa tcaccgggct taggctctcc agatagggag ttcgtattgg 46620
tgataaccag tgtggagcct ttttgtccgg cggcaatgcg acagttgttc gcatcccctc 46680
ttactcggta agactcgtaa tgcgggagta taacgtcgag atagcctctg gtacgcttat 46740
actctagaat tgctgacgaa agtacagcat actcatcggg aaacatcata ggataactaa 46800
tgttaagacc ccaatactga gtggctgttt taacttcgtt aaccttgccg tttggtagct 46860
catctctgat catcggatcg ttatcgatca gcgtagctct gtcaaaccca aggccgttat 46920
actgaggatg tgtaaaggga tctggtaatc tcatgttttg ttttctcctc tcaatgttaa 46980
tattatagtc atatcaagaa aaattttcaa gataatttta taaattccaa aaagaaggga 47040
ggacaattac gtcctccctt tagtttagtt aattcaggtt ctttaagctc agcccttgtt 47100
cattcaaggc taactctaca gctgcctgga atgccgcagg gttttccaat gcgtactcca 47160
taaagctctt agcatccatt gcctggatat tcagatgaac cggtcttcca gcaccgccag 47220
aagaagtttc agaagctact ttatccgctg gagttacttt ggtaggcacc ataggagttg 47280
caacttccgt accatgttca cccatcttat aggagacacc tggataggta ttaccaccct 47340
ccgcacgagg aataaatccg ttagcactac ctataccttt atcacctcga acgtaagaca 47400
gctcacctgc gtttgcgccc atactaacgt ctacgttctt ctggcgctca cctaaggtca 47460
ggtaagaggc agtttcacct ccagaccctg ctatatcggt cattccagta gcactagacg 47520
cctgtgctag agatagagca cctgcaagtc cagccgcgat cataagagga atagagaacg 47580
gatacgggac agctgttgct gcctgcatta ccgctactgc tgtctggatg atgatttgct 47640
tcttggcaga ttcctgctga agtttaatct tctccgcttc catcttcttg atcttgttct 47700
tagactgctc agatttaccg tcacgcttct gctccgccgc gatagctgca tcaatagctg 47760
aaatctgctg gttagtaccg aagctgatca tctggctaac tgtctgcata cctaccgcaa 47820
ccatagatgt agtatctaga gatttctgag agaactgaat catggcgttg gctagattac 47880
ccatactttg agcagtagca gtagcttcag agtttaattc acttagtttg gagatagctg 47940
tgtcataaga cgccatttgg tttcccatat ctgcaaattt cttatcatct ccggctaatc 48000
ccgtagttgg ggtatagtct gcgcccaacg actgtcctac acctgcctgc atctgagcat 48060
tacgttgagc tgctaatgcc gccatttgcg cattagtttt tgctatctcg gcgttccatc 48120
gcatctgttc atcagcatta cctttagtaa actctttcat ttgtttgtag aattctagct 48180
gcaattccat cttttgcatc tcccctgcta gtgggtacag gctagttagg gtattctcaa 48240
atgcctcttt acgcatctca gcagtttttg cattacggtc aagctgctct ttccagattt 48300
ccctttcaat tgaagcgatg ttacgtctag actgctcggc ttccttctct ttgtcagcct 48360
gagtcttcag cagagctaac ctatctttct ctacttccag atttagttta aggttcgcca 48420
cgttatactg ggaatctgtc atagtacggt tagagagtag agctatctcc ctgtcaatac 48480
caactatctt atccttgtag aacttctcct tcttagtaga ttccatgccc tggtttttaa 48540
tcttgaactc ttcagtttca agaatagtta gttccttttg tagggctttg ttatccttat 48600
tcgtagccag tactgcctgc agagcagctt tcttggactg gagctgttgt agctctagtg 48660
ctctaccagc ttcttccgcc ttatccttat tacgagtaga tgcgtaaaca tctgctatac 48720
gtttttccac ttccagctta gatttggctt catcccctgc aatcttatgg tagttagtca 48780
tagccttata agcagtgttc atctccgtta cagaagagta cccaagattc agatccttag 48840
ttaactggtt agctttttca gtagagcccc cagccagggc ttccactgct ttaagagcat 48900
cccctagagc tgcggtagcc ttagccgccg tattagaatc ctgtgcgaag ttttggatat 48960
cattacccaa gtctccagca gttttcttaa tattgttgta ctctttgttt atggcaactg 49020
ccccacctag agcatccttg ttgaaggtgt aaatcccgtc acttgcttcg acgttctgcg 49080
atatattaag ctgattggct aggctagggt ttcccttctg agttttagcg agtgcattgt 49140
ctctagcgtc tctccatttc tggatggctc cagatgagtc ctccaattcc tgttgcaact 49200
tatacgcttc acgacgcata tccgcagttt cttgagtgaa cctcttgtta gcctcagaag 49260
ctcctaaagt gaaagagttt cctagaccct ggtagttggc attcacagca agtttagtag 49320
ccatatccat cttagattcg cgctctagga tatccttgtt aagagctgca agtctcttgc 49380
tggcctcttc cttggctttt atagcgtctt ctaatccttt ctgagatgct tcaaggttca 49440
ttaccacggc gttgttatct ttaacatcca tcttacctat cgattcctgc tgagcttctg 49500
ccgctgctga ggaaatggag gctttagagg agtaaaacgc tgcgtttata gatgcaatga 49560
caggtccaag atacttagcc gctgcctgct gaaccttacg tagtgcagag tccgcattcg 49620
cagcaaactg ttcccaagga gtagcacgaa gtgcatcatc aagatatccg aaacgcttag 49680
tagattctgc tacaactgcg tttgcatacg cttgctgttt ctggaatgag gatagactct 49740
gtatgttata agtcataccc gtgttagctg cgtttagttg tttaacatgt tcggcgaatg 49800
catcattcag acggatggtt acacccagtt cgtccagaag ttcgatttcc tgcttagaca 49860
cacccttaat tacacggttg agtgcatctg tcatgtcaac acctagagtg gctgcggctc 49920
tacgtgcaac tagagcaaac tcaccaatct gtttagaatc gaaaccatat gcggccgcag 49980
tagacgcctg gcgcatagcc tcctcgaagg atacggcata accagtagct tcctgcagtg 50040
cgattgctag cgattgaatt ggtgtacctg tcttagcacc tacaatagaa ccgaactgct 50100
caagacggtt tagctgatcc cccatcttta attgatcaaa agctgctttc agtacgtaga 50160
ggttggatgc caatgcacca tataaaagcg gcataggtcc agttaccata gctagagctg 50220
cgaagtttct tgtagcacca cgagcggacc ctgaggtatt acccagcgcc cttgatgctc 50280
ttcctgcggc gcctccagta cctgttaacg ttgagttcag cccgcctaaa ccagtattaa 50340
catcacgaac acccgcgttt agatctgtta atttgtcaga taccttgtcc gtactccgtg 50400
ccatatcagc catggtggta ttcattttgt tgcccatagc ttcaatggag gttacaatcc 50460
tgttcatttc cgccactaag gcacccatat tgaatgctgc agggttgccg cccccaccag 50520
cttgtcctag gcgtatacgt ttggctatta acttatctat cgcagcagca gaacgtatcg 50580
cagcagcttc aatagcgttg agctccggta ccactttctg gaagttatta atcattctcg 50640
tagacgacga ggttgattta gatgccatat cctgaaatcc cttggagaac ccgcgctcta 50700
gtatttgaga cgtggaggcc agtttagttt ccagagcatt taatgaggcc gttactgctt 50760
tgaattgggt aggtaattga agtacgcccc tgcctgcctg tatttttgac agagcggagt 50820
taacttgcac agcggcctta gccagctggg tgagtgacgg gatcatacct ctgatggagt 50880
tacccagtgg attcaggttt cccgtgcctc ccatagtggc aaaagctcta gatagatcat 50940
ttaggctttt ctcgataccg gttacagatc cttctaactg agcacgcaac tgcgtcattg 51000
aagtacctat ctttccaaca actgtaggta cagaagaaag atttgcgcct gctttaatgc 51060
tctgcagtgc ttttcctgct gccgtagcat ctacgttaag ctgttttaaa gcggctgtta 51120
ctttagagat atccgaagtg gaagctgagg tggctgttga tatctctgag attagcttgc 51180
tcagaccact tccggttcct acggttttca ttgaagcggc agctgtagcg gtagaggata 51240
ctaaagacgt aagggctgct ttaatcttag atatctcagc taccgaggta ttggctgcag 51300
tagctaaact agtattaatc ttctggattt cagttcccag actattcagt ttggtccctg 51360
gtgcaatatt tgctatagat ttactcgcta aatcagcttt tactgccaac tcaagaagta 51420
gtttgtttag cttgttcacc tcttcgccca tagaagatac agctacggaa atcccggacg 51480
cagccttact cagatgctct ccggcagccc ctaaggagtc ggctttcagc ccctgaagag 51540
acctgcctgc cagcacggct tgctccgcca ttctagctaa ttggttacct atcttttcca 51600
ccccagatac taggtggcta agatccgtac tagccttagc agcactagag ctaatagatt 51660
ctaacccggc ccctgccttc aaggtctgca acactttagc tactgaagag gcgtgtgcat 51720
ctaactcctg aagagcctta ttgacgcggt ttaagtctgc aactgaagaa gtagctgctg 51780
agtcaaaacc agaggccatc ttgttagcgg cggaagtcac cccgtttagg tttgcgttga 51840
tttttagtac ggatttagcc aagtcaacct cgaacgaggt aaacttgccg cttagcatgc 51900
cgatagatgc tgctaatgct gtaatgctgg tggtcgagga tagtttctcc agcgacttag 51960
cagtacgtga tacagatcgt tccagcgccg tgaaagaccc aggaagtttg cccaagcttg 52020
tatttagacc ctcggagctc tgagtagctc cgtctaaagc agcttcaaca tccctgattt 52080
gcttagcggc tttggatcca ccacgctgct tgatatctac aagtaattct cgtattagtc 52140
tatctgtcat gattttttcc aataaaaaag gcctagggca ttaaccctag gccaagcctc 52200
acgtggaacg cccgttggag gaaaatgtaa ctcactatct gctagaagac ttcattttag 52260
acttcttaat agctgcttca acacgtttgc gagaggctgc cacagcatgt gagtcgaata 52320
tgttgatgat ctggagtata agactcttct catctggatc ctcgactccg tagatatcga 52380
agaaaactag tagggcactt ttatccttgc ctaaataggt tggataatcc ccggggatat 52440
aattgtccga taagttgtta tatattgtta gagcggtctg tgcgatttca gggaagtcat 52500
ggatctctac gaaacgttta agtacctcgg ggttaggttc ctccccgagg gattcgcaca 52560
tcgtcagata ctgctcccgt gtaattttgg agtccccccc tttgacacat cgttctgcaa 52620
aggcatctat ttccttaagc agtaggttcc gattttgagc cacgaaaggt gtctaggtgg 52680
aagaccgtgc tattcatcca ggtctcaaag gcactggagt tacgcaccaa catcatcgcg 52740
ttgtcgatac taaattcgac cttatcttcc agacggtctt ctggaacttc gatcagcatt 52800
agcttctcaa catcagctac ggttagacct tcccagcctg caatagccac cttgacgaac 52860
tcttctgcga atttgtcgtc gttctgcact ttaacagcga taccattaac aaactggttc 52920
tcttgcgcgg cttccaggat tttcttggag agcttacggg agacgtagtt aactttcagt 52980
ttgaagtgtg gtaggccagg gtatgcaatg gtgatctgtt tggtatccag tgcaatatct 53040
tttaggttaa tactcatttg ttattctcca attagcttga ttcggacagg atctgattgt 53100
tcagtaggta ttacgtcata atcgatcttg tacacgtcgg ttaagtctag gcgttttgtg 53160
attcgagtgg aagggaaatc caccacaata tatttatttc tgatttgtac cggtaggcca 53220
atatcaggtt taatgttatg cgtagagtct atctgaagac tctttgcata gtacatcgat 53280
atcaaagcgg atgagttcaa ttcgttaacg attgcccttc tattattata aatcttattg 53340
atatcgaata aacttctgtc accccgccat tcacattgct gctggaatga cataccggct 53400
gacataagtc ctgggagcac tctcccattc gaagatacct gaggcaatga aaatggtagc 53460
acctcacctt ggtcaagcgt atagctgttg agtgggtggc ctacttcctc aaagtatccc 53520
gactcgatac caacgtttag caccgggaca ctcttatcta gagaaaagtc gcaggtggta 53580
gcaaaacagt tatcgaaacg taagctcgtg ttcttgttaa taatatatac ggagaacatt 53640
ttaggctcaa tattattact gaacaagggc atctgataca ttccgtctat ctctataaac 53700
cccatcaatt cgaaaaatag accttcgaga gcattgctag agaagttaag agttagagaa 53760
attgaagaag gagactgagc agttatcttc gaataggcgt agttactgcg tctgtgaatc 53820
gtcctacgat tcgctttaaa ctcttcgtag gacgttccag cagtgtaatc agacagggcg 53880
tcaaatccgt acgccctgcc atcgtactcg atgactactc tagactcccg cattagggag 53940
tatagcatta gttatcctta ttaaccgcct gaggcagcct taccgtcacc agtggagatc 54000
agcttagcaa ttgaagtttt agtatacttg gcagagaagc ccaggtaacc ttcatcacca 54060
gcatccatct gagatggaat agctttgaac tcgatagata cgcctagcac atcatcggtt 54120
tcgattgacg ggatattcag gttagcatgc ttagccacca gaacagctgc aggacgtgca 54180
gtatcgtact ccccgcctag gatgattgca acttcgaagt cattcacagc tttcagctcg 54240
gagaccagat ccttgtacaa ctgaatagag ccgttagcag catcattcat gtatgcagtc 54300
agagaaccag taagctcgaa ggagccagta aatgagccga tcggaacatc aacacgtgac 54360
atgatgttag gcgtcaggta cgttacgttg ttgttcatag tgaaggagcc accggtgatc 54420
gggatgttat aggtcttacc accaacagcg ttgttcttca gcttaaggat agtcagcttg 54480
ttcttgatat aagaaccttg aagtttagca tacagagcat cattaatccc aatggtgtta 54540
gggtcaaacg gctgtgcaga caaagtttcc agacgagtac cattacccga ccaggttaca 54600
cgaccaatgt cgtcgatatc cacgttaact tctgcctgcc caacctggca gttcttgatc 54660
acagaccaag cattgtcagt caggatgtag atatgcagca tggccagttc gtggtatgcg 54720
ttatccttga agttgacaac aaggttggta tcgttctgga agacaccagt agtgcccgct 54780
aggttcaggg tagcacctgt tgacaggccg tgccagagta ggtagtccgg gaggatctgt 54840
ttacctgcat cgtcatatgg caggatatag gtggagaagc tccactcggc agcgtttaac 54900
gaatcgttga agcgctggga tccacgagtc ggcttcggac cggcttcgtt taaagtaata 54960
tcagtggagt tactgtcctg accccaagag atgtcgtcct ggactaggat ctcctgagta 55020
ttggtcttag tgaaccccgt agtaacggtt gacacgaaga ttcgtgtatt acgtaatagt 55080
tgtacagaca tttaaatttc tcctgagctg taacttatct atccagcgct cttctcagag 55140
gcatataccg gactgttacg ttaacttgag caaaaccaaa cggggacagt ataccctcgt 55200
ctgtggacac cgacgtgatc tgcatgtcag tggcttcaga atcgatagtt gaaccatcag 55260
gtttcattat agtatattgt aaatttcctc cagtgtcaat agaggttttt acatccgcta 55320
tgagtttctc aagttgcatg ttaatatcat ccttttcttt atcatagata agaataggaa 55380
tttcaaggta aacccactgc tgtgcagacg gcaggtagtt tccagtttcg gtacccacat 55440
ggactgctat gtaagggaac tcattgatct gctcaaacga ataagtttgg cgggatacgt 55500
tcccatacat attagtgaag aactctgtgg gattactccc atccatgtcc ttcttcagtc 55560
gttccactag ggcatcagca atacttgttc tgtaattcat tatgtaccct gatttactct 55620
tatccggtat ctagaatgga taaggtctct tgcagcctta gcgattgcct cgccgatcag 55680
cttctgcggg ttcctagcgc cagggaaagg ccgtaaggaa agtccgcggt aggtagagac 55740
ggcaggattg aacacagaat aaggcttaag catatagtta tacgtgatgt tgagatcagg 55800
attctttgac cctgcgtctt ctcttaacag cacgtcttta attttcaagg agttagcgaa 55860
acgccccgtt ctaaatttaa ggggtgcccc agcttttttc atatccttga ctaagtattc 55920
ttttgctacg agttcaagta acgctctaag gtttgtgttt gagacgaaac gcccagaagc 55980
gccagaaata gcaccagcgt aaccgttgtc agcatctgaa gggtctccaa agttaacttc 56040
taccctaccg gtagatcgtt ttcttcctat tttggatttt ttaccagtga tactatttag 56100
aaggttatcg ataacaccaa cgtcaccttc caggttaagt gacgacgaga cagcttttaa 56160
aatagaggac gtccgaacat tcagtaaatc ctccgatacc ggcttggtaa atcggaagga 56220
taccttgcct atggtgccat ctttgtggtt atccatagtt tccgcactat ataccacggt 56280
gttcttggta gagtggctac caccactcat aatgtccagc tgttctttaa ctatctgtcg 56340
agctagatcg cccaacgcca ctacagcctc cgatatactt cgattatagt acggatgtgt 56400
tccggtacgc cagatttagt ggtattgaaa gtaacggttt ctccgccaaa tgtacgagac 56460
tcgcggtagt ccttcttgac ccaatgatca actaggaagc aggctgctag taccaagtca 56520
tcagggatag aggtaaagcc ggtctgagta aactctactt ccatataccc ctctggagga 56580
gagaatttca gcaagagcgt accatccggg tagttcttat attgcgactt atcgatctcc 56640
tgatcgttaa tcgtaatttt agtgatcgtg ctaggcacag gagaagacag gaagtacttt 56700
ttgcgtgctg gtttagtagg caaaacgtct acaacgctag cactgtcgtc aatacctaga 56760
agctgagtaa tcagagcatt agccgccttg attaacattg ggatatttga ctctaagtca 56820
ggacgtttaa ggcctccata tgttctccaa tcagaatctg tcatgaattg catattttac 56880
ccaataaaaa aggagagccg aagctctcct ttagtcggca gtatagccaa attaagcagc 56940
gtaagcacca gcaactacgc cgttctcgaa gaaacgcatc aggttcagac gctgagtaac 57000
gtagtacgca tcgcgctgac gttcagcctg acgctctttc tcaacagtga ttgcacgctg 57060
acgaggaacg atgaagttgt cacggtaaac aaccacacag aactcagcac ttgcagcctt 57120
agctgggaag aactcagaaa ccagtaccgg cagaccgtag atgcgaccaa cctgaccctg 57180
cagtttgata gcggtggtag cggtaacctg tgcaacgtcc tggaactctt catcttcgat 57240
cagatcgtaa taagcatcca tcgaaacaac cagagccagt ttgttcaggt ctagaccgtg 57300
gcggcccagc gaacgacgca gcttgtgaat ttctttagcg gtaactttaa cagaaccgtc 57360
agctttagca gtggtagcaa ccactttacc atcgtcttta gcgaactgga tcagaccttt 57420
cggagtacca gcagcaccag taccggtcag gaacgctttc tcgattgcga tagcgtgagc 57480
ttcaatcaga cgacgacgca tgatcggcag cagagtgaag atagcatctt cttctgtttc 57540
gtcggtcata tacgctttag cagccagttt gtaagtcttg aaggtgattt cagacagctt 57600
ggttttgtct tccgcaccaa cagtagcagg agtaccgtag gtagaggcgt caacccagct 57660
agcttcacca gcttccggct caaccatcat ggtcagcaat ttgctagaca tcggcagttc 57720
ttcgaacatg gtaccgataa tcagtttagc ctgaatgtca cgcaggatac gcagggagaa 57780
gatggtttcg tacgcttcgg tagaaacttc gatagaagaa gagccgttaa cagctttcag 57840
gtgggcttcg ccacgcttag taccgaatac atctttctgc attacgtagg acagaagaac 57900
cagtttctca acttcgtctt cgaaatcttc ctgcttacca aacattgctt tagcaacgcc 57960
atcagctacg aaagagcgac tattttcacg tgcggccagc agagatttga tttcttcctt 58020
cagaccggtg atttcttcct gctgtgcttc tacagcttta gcgaatacgc cagcggattc 58080
tttggacttc tcgtccatcg ctttaatcag ttctagagct ttgctcagat cttcctgagt 58140
tttaccagag gctttagcga ccaggtcttc catacgcttc agctctgcgg cttctttctc 58200
ggcagccatt ttacgggctt cttcagcttt ctgcgcagca gtaaggcctt tcagagaatc 58260
agccagttcg gtcaggccca gttcctgttt cagtttgtca atatcaagag gtgcagacat 58320
ttaaaatttc tccattatgc cttaatgcag cccagggccg cggcaagttt ttctatttca 58380
gaaagttgtt tttcttctaa agcaggctgg gcctgtgaag atttaatgaa agtcttacga 58440
atttccatgt aatcattatg gtttacagac ttcgaaaggc taaaagttga gtcttggttg 58500
cagggaaccg agactacaga gatctcgagt aactccagat ctttaataat gaacgtttca 58560
gtcatatcgt cccattcggc gtctttaata tagaagccta ccgagaacgt tttaagaacc 58620
tcatcacgta ttaatgagta aatctgtaga tcagcagcac ttacctcacc ctcaaccata 58680
agtccggact cggttggtac caggtctagg atcttaccaa ttgggcggct atggttatgg 58740
ccgaaaagca tgatcgggtt cttcataaaa ttcttgaggg cgttactggt agtccacgct 58800
tcggagagaa taacgtcgcc ggcgcggtct ttggtaatcg tgttagcata ccctttgatt 58860
tttaaaggag gattatcacc ctcaccgaca gctttaacag atttaatctc agcattaaga 58920
ttaatattct gcatcgtttg ctccaaacac tttcgtgttg ttcctcagtt ttcagatact 58980
attattacat accaaatcgc gaatgtcaaa agatatttga aaatcccaca cggtgtgtgg 59040
aattagtagg cagtcgaaat tggttacact gaaaatagtt atgcactagc atataaaaat 59100
ggggagccga agctccccag ttaacagata ttacacaggc tctgtaggaa ccttaacggt 59160
tactgttgca gtgtcggtct tattgccgtc agctgtttta acagtaatga ctacagtact 59220
atctgcagct aagtcagcgg gaacagttac cgtaccatcc gcatctacag tagctttggt 59280
agggtcagca gaagtgtaag ttacagactt attggtcgcg ttagctgggg ctacggtacc 59340
agtaagcttg ccggtcttac ctgcttcgat tgtaatcgtc ttaggtgaca tagtgacacc 59400
ggtaactgct accataacag gtttggttgc ttcttcatat gcttcctcaa actgtttcca 59460
ggttctacga ttagtcgcag cgtagccgta ctccttacgc agaagctggt aagtgagatt 59520
cgctttaaca gttgccatca cattgtgagg ctctggcagt ccgttaggga atagtgcttt 59580
taaagcgtta taatcaatca ttctttttcc tcgtctttat ttggtgcgcc accttcttgt 59640
ccacttactc cggtagctga tccagctacg ttggcaggga tgcgaatttt cttcatctgc 59700
tcgtcagcca gttcctcata accaagctct atacgacctt cgttaccagt aaggatacca 59760
ttgttgacta gtgcagttac gaatttagcc tctttctcct tgtcaggagt tagtgctact 59820
acgtctttag tattgggcgt tactttaaaa ccgaagaaga acgtaagaga gctacatact 59880
ttattgagca taggcacaat agtcatgtag tagaacagct caatgttcgg tcgaatattg 59940
gcgttgttac ccccatcgat caatagttgt gggactccga gagcgataca tacgtcttta 60000
ttaaaacgag cgatatcgtt ctcgaaatcg agatctttaa aggaggagat ttgggagtat 60060
ggcttagcct tcatcccgcc gtctagaatg agcacagttg attggccggt actagggtta 60120
tagtccagct gaagctcttc ttgtttacgt tcacggagct ttttatttag gatttcatct 60180
gtttctagaa taagaccgat aaccgtacca ttgtccagga atttctcctt gaactcaagc 60240
attttctcac gcttagtaag tgagttaatc acggtagcta cgcgtgactg acctgtgatc 60300
tgggagttaa taccactatt ctggccgtta tctttgatga agataatttc atcaacgcga 60360
tagtcgatca tattattaaa gacgaatttg ttaacgaatt ttttgtcatc tgcttttact 60420
tccattaggg cagcaggcag atggtacaga gacgaaccgt cccaatggat gtacgcacag 60480
ccttcgaata gaaggtcaga cactattagg cgtctaaaag tactggaatc catgtacggg 60540
ttagggcgaa cattaagcag cgtctcaaga gttttactcc tgatcgtgcc ataggttgtt 60600
attgttttat actgttcacc tacggtgtag gagcactcag cggcgctgtc aatcaccatg 60660
ttcgcggatc tattaaggat ctcaatagac gaataggctt tgccagtcgt gaatggcttg 60720
acgttagtac ggtgactaac atcctccaag tccctgatta tgcgttgtcc gcggtttagt 60780
ttagtaacta accagtcacg aatagccatt ataggaacct tgcgaatcct gatttctcag 60840
tcttgacgtc agtcggaagc cacttcgcaa agcctgatct ttcgccagtg ttgcttgtac 60900
gaggtgcctc tggattcata catctttcac gttgtctctc aacccaaatc ttctgtttgt 60960
tagctgaaaa caacggcggt tctttcgtat agaccttgtg cagggtctga tgatgaaaga 61020
cacataaggt gaccgtgtcc tctactagct catgccaata atgtttatag aacttatccc 61080
gattacttag gacgacttct gagtcagtga aatccagttg gaattcttta gcaaagtttt 61140
taactagtaa ggccacagtc gagtagtggt gtagctccag gttttcctgt gagtcacaaa 61200
tggcgcaaca ggtgcctctt ttgtactggg ctttgattcc atcacgcatt atggagattg 61260
catctctctt atattttaca ttggaagcca aagtgtttct cctcttagtt gggaaaatac 61320
tacttcgggt acagcaatta aatattcctc tcattcaccc tgatgtctat gagatctctc 61380
aaggtatgaa tatattataa ctgccacaca cgaaattgta aagtgaattt tataaagttg 61440
gaacggaatt tgtactcact actatccgtt ccaactcagc tcttatttgc cacgggaaat 61500
cgagtagatg ccgtaacgca gtgcatcaca taagtgagag ttggcatcat gacgaggttt 61560
ctctctggag agcttctcct ccccttcctg gaagtcccac ttgtagttct ggagtgcgtg 61620
aattaacgca gtgcatgagg cgtcgacgat aatcttgccc tgctggaata aagccgctag 61680
gcacgctagg ccatccagga cagatttctt agcaggagca gaagatattt catgctcgta 61740
tgccaaatcc tgtcggaact gtgcggctgc tgagtcaacg aagatacggt ctacgttata 61800
ccggtctata cagtgttgta tgtacatggc atgctgtgct gtagtcttct ctgcctgctg 61860
atattcctca aggatatagt aaacgtcctg atcatagtgg tacttaatgg taaggactgc 61920
tgttgggtct ctgtaaccaa cgtcgatacc tagaatggtt tcgaactcgt ggtctgctgc 61980
aaagaagtga cccatacctg caagatcctg tacatgctcg gaaacgctaa aggtatcgta 62040
gatctgacct tcgaatacgg agaagtccgc ctcatattcc tgtttgaaat agttcttaga 62100
tacagtctta cgtgcttctt cgatatctgc aagagatacg cgagggttat ctcggtatgt 62160
accgtggatt gatacccact gcggaagatc ttctcggaac ccctgctcgt agaaacgttt 62220
gaaccagtta ccaccacgag gagtagagat aaacagggct ttagagttag gtttgtccag 62280
tgtaggacgg agctggatat cgaaagcgtc accaccaacg tcggagattg ctgcttcgtc 62340
aaagataata aagtcatagg aacgaccaac cgcggagtca gcctgcgcag cagaagctag 62400
cttaaagagc gaaccgttag caagttcaat ttctttatct ttggcgttct cacgctcagt 62460
ttgaaggcca tatttcttaa tcagaccttt gatctgcgcc cacccgatgt ttgccaggga 62520
gtagttcgga gctactacga gcaccttaac gttaggctct aggagtttga ggaagcctag 62580
agtatatgca atgaacgact tgccaacacg acgggatacg catgctgtaa tgaaacggtg 62640
acgcgggtct tccagtgcat ttatgattgc gcactgcgga ccatttgggg tgatgccctc 62700
ggtggccagc aagccggaca ccgggaattt aaagaatcgt ttatcaacac caaaatccac 62760
cacgtcagtc gtattaatat aactacgtga gatttccatt acttaccagc ccccacaatg 62820
cgtgacagga gatccgtata gttagagtcg tgaccacctg ccaagttgat ctgagtatta 62880
gtctggtgta caggagcttt agcctgcttc accttctcat actcgatctg catcttcatc 62940
tcatccatct tcattttgtg catgagtttg aggatatcca taatatccat ctctgaaccc 63000
attccagttt cctccagttc ttccatcttc atggttagaa cagtgtctag aataccaaag 63060
aatttatcac ggttacggaa gccagattcc atgaagatat ccgtaaggta cgctttgacc 63120
tcaggtttac gcataatctc acggaattta ggctcttcca tgccaacagc taacgctgct 63180
ttcgcaacgt cgctgccaga ctccaggtag gcctcgataa ctagcatgcc ttccggagac 63240
attgcatctg gtacaattaa atcattgctc atattgcctc cttaggcaag cctttgcaca 63300
gcaatcctaa cctcaggaag aatcacgcgc atgttcataa tattgctcat ctcaacgtta 63360
acccaaacct caacactacc gtcagcccta gctatcagcc aatagataat ggcataatcg 63420
ccctgagtgg cagagttggt agtagtaggt gcccacatag ccttcatttg catggcgttg 63480
tgcccaggaa taaccccaca ctgggttacg gtcccgcgta taaagtggaa cggcacacac 63540
atgttaactg gaagacacat gatttgatgc acacgtttct ggaagtgatt tccgaaaatt 63600
ctcagcctac tatctacctc gctccactgg gtaagatctt ctagagggtt ataacatcca 63660
atccctgcag cagcaatcca ctcatcgttt ttccagtcta gagtgacgac gcaagcccca 63720
tttcgggagt tattaacccc taaccacaag gtagccaggt ggtgactagc attaccgcta 63780
gtacgtaggt tccctccaat atcagcagag ccggtaccgc ccactaggcg aagaggtcga 63840
gttgcttcgg accatactgg accccactgg tttccaattt ccggagggtt ggattttaca 63900
taccactgcg catcagatct aaaattgtaa actcctacag tggttacatg catctcactt 63960
atgttacctt gcccaaattc cgcaccatta tctggtcgag ttagaggctg attgaagtga 64020
acatatccat tattaccaac agtagggttg ccactaaatc tagcaacatt ggtcgcaata 64080
actcggatat ccggcctatt acctgggctg tagtttatat cgttctgatt tatgaacttc 64140
cacccagtgt tcattaggtt tataccgttt acaatgaact ctctagggct gattttaatc 64200
tcctggttgc gggagccaaa tacgttctct gcgtagaacc cctgcccatt gtatttcata 64260
ttagtaatat accagcgaac acgtttagga acacggaagt tattgtcacg gtaaatggca 64320
ttgttacccc aaccactacc agcattgttg ttatctgtgt tctcccaccc cataaagtta 64380
ttgggcggac cacggaaaaa acctgctttg tactgaacct cctgataaga ctcagtctgg 64440
atgttatgag cataaggacc accaacggga ttagacccct taccgtatct aggccccata 64500
tgtccgtaca tattacggtt gagagtctca ccacgcaaac atatactatt aactcctagg 64560
gtacgcatcc atgggtggcg catagcatca gcaccaatag taagtggtct attgggcgga 64620
gacacagaac cggctatatt gccactaaaa gcccccctat agagcaccca tccagcttta 64680
ataatagtct caaagttagg acgtatagga gctccaaccg gcggcccagg ccctctgtcc 64740
ccccattctg agttaacgcc ccaggtgtac atacacccag taccatctcg tagcttctcg 64800
ttaatagtac ctggcgtctc ttcgaaatag aaactaatat ccatgtgtaa gtctgcagaa 64860
gcacaaacgt tagtcttcat actagccata gtacctgcag aagcctggga accgacagta 64920
ttactaaagt aagcgttata cgctttagcg ccaacgccta gagaagtacc ataaatgaaa 64980
cgtctagtac catcctcaaa ctcaacctca gttaagacaa ccctgtcgta gtctgcggac 65040
agtacatgaa taatcctatc tggcattcta gtacaacgat accaatcacc accatcccag 65100
aggtctcttt cgtgagtttc caaaaccaca acgtgaggca tgtcactatg gaatatagta 65160
tcccaacctg gatttgtatg gttattgacg tctttattgt tgccagaggt gagagacaac 65220
acttttttgt cgcctatcct tcctgcgtaa aagcccataa aaacctcaaa atctcacttg 65280
ctaacaagtg acttttataa tataatatta ttataaatta aatcaaccgc caagtaaacc 65340
agatttttta aaaccatcta ggaggaccac tatggaagta gttataggag cacttgtttt 65400
actctcaatc gtactatttg tcattaccgt aaagcaaggt aagataatca aacggctaga 65460
acgcactaac ggggtgttgc aaaagtctta tgacaaccaa acccgtttgc tgcataaggc 65520
gcagttaaac ctgtctgaat gcaaggcaga actagaatca gcaaacaaaa tctacattac 65580
taagggtatg gtgtaaaaca tgactattgt attaattttc acaacattct ttttcctggc 65640
aacagtttgg ttcggtgtgc gggcacatga cctgcggaac gcggtagtag cggcagatct 65700
tcgtaacaaa agtctgcatc aagagatcct tcaaactcgg gcggaacgtc aagtagcgat 65760
ctcgaaacac caacgagtca tgaacggtct tcggaatgac ccgagcaacc cgtactacat 65820
ccctccagtg acaccgcagg tagcgagacg caagcagaat cgggggaact cgggaagttc 65880
tcggcagcta actaataatt cttcatcgaa ctcgggaagt tctcggagcg atgacgggtc 65940
gacggcggca atcatagcta caaccgcggc ggttgctaca tatagcgggt atgactcggg 66000
aagttcttac tgcgacagcg gcagtagcag tagtagcttt gattcgggat gttctttctg 66060
atgaaaccca ttcctctaga ggttctagag tcagtattct acgacccaga taccggggaa 66120
gctcattgcg acctcggtag tattaaacgg gttgacgatg gttttatata tgtacaccca 66180
aggctcgggc agttctccct ggcacgagtg ctgtggatgc ttgaaaccgg ggaagatccc 66240
ggagagttct atatagacca caaagatact gacccgttca acaacatttt cagtaatctg 66300
aggaaggcct caccctctca aaaccaacac aataaatcgt taaataagaa caatacctcc 66360
ggagttaagg gtgtgtactg gtgtactcgg gctaaaaagt ggagaggacg tatacttgta 66420
ggaggtaagt gtgtgtggag caagaatttt actgagttag aggacgccgc tcgggagatt 66480
tctcgggcaa gagcggagct acacggggag ttctccagag attcctaatt agcgctaaac 66540
ccaaaatctt gaaaattcat aaagttttac gtggggatgg gcttagaggg ttggggggtg 66600
gtatggtagt ctgaaaacgc ccctcctggt actactagca aacaaactat tagtacccta 66660
actatttcgc tagggtacta ttagctttct tatgatgcga tggctaacga ttgaatgaat 66720
tgttgcggct taactccata gtcgcttctt tcttcttcgg tcataccttc ccagcagtgg 66780
gttaaacgtt cgcaaagata ttgataatca ttatcatcgt ccagcgcttc atctatgaat 66840
gactcacccg caaggcgcac accaatagac agaatatcgt taattgcggt agcgtccatc 66900
gtttgaaggc cagcagcagc agcagcagcc aacacgcctt tattatcgtc tatcatggtg 66960
atagtagcgt tcgggtattc agctttaagc atttcgaaat aatgcgtttt atagatacca 67020
tctttcgaat agtacacctc tttataatca gcagcgccaa tatatcggtg caatacatcg 67080
cgggatagta tctgaatatt accaccgcgc cccgccctga tacgttgttt ccgtaggaaa 67140
tagtaatcac tttttcccat atagcgagcc gtaacaataa tgtttaatac agtgggatca 67200
ttaagcgatg cccgcatata ttcaaccaaa ggtaaaagag tatcggccat aattgcatca 67260
tgtacgcaag ccttttcccg gtacatgttt aaatctaagt tccctctatc atccatacac 67320
gggaacacgc gggcaaagga attaataaca gttccgtcta aatcccataa cttaattgcc 67380
ttaattgcca gtttattaaa agccattttc atttctccgg tttcggggtt gttggtaatt 67440
aatcaagcga gctatattat aactcgcttt gttaattatc agaagaataa agttaaggca 67500
tcggctaatt cagccggttt aatccgggta gctagtaccg ggacaattgc gagcggcggc 67560
gtatattcgc tagaagaata atccattaca tcgcctaaca gataagtatc atcataatca 67620
ttttcgctta cgacgataaa cataaggcca gcggcggtgg cgtcaatctc tacgatctcg 67680
cagatatcaa cctcataaag aatagaatcg ggcgcgacta attgcgacac aatgccggat 67740
tctttaaatt cagcggggcg cgggaggata gcggctagag cttttaaaac agtgtcgccg 67800
cccaccgtgt taactttctg atagctaaca tgcgggcgcc cttcgctatc gcgggtgata 67860
accagactgt tttctacgac gttggacgcg gtgaaagatt tacgattgtt atagatgaaa 67920
gtaagtttca tttgtttctc cagcttattt atttaggggt tatttattgc cggggtaatt 67980
gccccggctt ttttgttatg caaagaaaac gccgtcttta aagtcaatca aggtacgttg 68040
gccgttttca taggtgatta gatgagtctg tgaccagcta gacgcgccga tattgtaacc 68100
catatcgagg gaaccagcga cgccagcagt ataaacgccg ccgtagatgc taggcgtatg 68160
cgtatggccc gtgttcatct tgccgagctt acggaatcct ttcgggttgc cgcgagcgcc 68220
gttaatgccg ttgtgaccgt gggaaccgca ttcgatgccc gcgattttca tcgattcatc 68280
cgtggttagg aagatcgcag caaaatcgca gccagcaaca ttgcgcaggg cgtaatctag 68340
tacgttaaaa gtatcgtctt tgttttcgat tgcctcataa atcgcagcat tcaggcgata 68400
gtaaagatgg ccgttcgccg gatcttgctg aatgttagcc ttgctatcat ccagccagcg 68460
ggatagcgca agatcgtggt tggattcaac aatgaccgtt tgactgaact cacgttccat 68520
tgcttctagt acgcgccccg tatcgatcag gtcgtcaatt accttgtcac gtccggcggc 68580
atattgtttc gcaaggaaaa cgccactagc gcggttgtga tggttgcgtg acgtaaagtc 68640
atgcacatca tgcacaatct ggtaacgagg gcgcaggata tcgactagcg cggttccgct 68700
agggttgtat tcccagcttg ccgccgcgac agcgtgatcc agtttttcgg cgtgtatgtc 68760
accatattgc agcgcggcaa catgcccggt tacttcttcg ccaccgttaa cagtaaattt 68820
atggttaaga tcgtaaaaca tcccgctttc gtccatcgtc tcaagctggc gagcaaagaa 68880
gttaccgttg tcatcgatct ctaccagcaa agcgccatag ttatgcagcg cttcggcctt 68940
ctggcccgct ttttgctgaa tataattttt cagcgtagct gtgccagttg aatacatacg 69000
gcgcaccgtg tcgcccttca ttgccgggac actttcggcg gtgattttag cgtgaccaat 69060
agccagccct ttcaggccgt aggcggtcgc tgtttcacca aaaccggaca gcggaaaatc 69120
agcagtcggc agaatgttaa tttccgccat gaatgcaaaa cctgtttcac gattgcccaa 69180
aaacacgttt tcatcacaaa tgaaatttga gaaagcatta tcatatttca gttcatcgtt 69240
gccttgccca ttctggaaac cttttttgtt gtaggcatat ttgctcacta gcagggttgc 69300
gccgagatat ttcgcggcct cctgtaaagt tttccagaag ttagcatgag ggaaggtatt 69360
attctgaatc gacgttaaca gaaaacgctt acccggaatt accttccagc tttcgacgct 69420
agaattaagc tgaccagcgg caacggggcg ggaatcttcc accgcaacac gttgggccgc 69480
aggtttaaca ggcttgttat tatccagcca atcgcaaatt tcgctagaat gcttcgccgt 69540
cccgtaatgc tctttgctca attcgtcgca gatctccagc tttttagcgc gcagacgttt 69600
accccaaaaa ttgaggttat ttgcggcggt taaaatagct ttttgtttct caattgcaat 69660
gatcattata taaattctcc agttatggga tataggcaga attgccaaat ataacgcctt 69720
gttgctagtg gcgttataat ttgcgactct aaactattgc cgggataatg ctggcggata 69780
ttccaaaaac tacagctaga ataataaaga ttattgacca gcggcggcaa atattcgctt 69840
tcttaaacca gaagtcacgg cggaataaat ccatttgttc actgcctatt tccatgaaat 69900
tataataacc atagagacaa gcggcggcga aaaagccagc gataagaatt aaggattcag 69960
tagggaaaaa gatcatttta caacctcctt ttcttctacg ctgaaagcgt attccattac 70020
ccaaatttca cgggagggta attccaacat ttccggctta aatatttcgc ggttaattgc 70080
gataccgtaa tgatcattgt cggggttgac gtataaaacg acgaattccg ggactttgac 70140
actagggggc gtcataatcg cgtcattctg ataacctacg cggattaatt catccacaac 70200
ggttcccgtt aatttaataa cggagccttt aattaaagcc atttttattt ctccagttat 70260
gggggacaaa atatttaatt atgcgccccg ctagggaggc gcattataat tattctgccg 70320
actcttttac ttcatcctga acgccaacca tacgggcgat aacgtccagt tgatccagct 70380
tcatttgttc caaacttgcc agaccgtcgg catcttcgat caggccgtcg gcaatagcgt 70440
gctgagtgag aacgcgcaca tagtgagctt tacgcaggga ggaaccgccg ccgactttgc 70500
gcggcttatc ggacttctga taaacctttg cgctaaccag tttagaacgc actttaacat 70560
gcgattcagc accgacagcc tttgcaatgt caatcagacc ttgcgagttg gcaacctcca 70620
gaccttcgga tgcaataatg ccttcataca tagaaatcgc ggtagcggcg tttgtttcgt 70680
tccatgcgaa tttttcggtt ttagtagcag tcatgatata tctccagttt tatttaaggg 70740
gttaggccag aaagttagcc gctatatatt ctagctagaa tatatagcga aaactcttta 70800
ttttagtttt caatttaaag ctatttaaag cggcattgta tatatacgct gcctttaata 70860
attacgctat tacgtctatt tcacgctata gattcgtgtt aactcacaat tgccgttcaa 70920
agcatgatat aagtttcagc acataagttt aatttgcgca ccataacatt gcctgcgctg 70980
catggaatat acatcggaag tctaacatat ggggaagcat cccattattt accggggtta 71040
aacttattgg ctgttaagcg acagccagcc acttatcatc tttgcgaatg actttcacca 71100
cgtcgccgga atctacccgg acgctgtaaa gttttaaatc gctgtttttt gctttttccg 71160
tttcggcgta taccgcatta attttatcaa acgggatcat cgccgcccct ttgatatatc 71220
cgattttttc attttctccc ggcttactta cgtcgccagt aacgaaagga ataaaaacgg 71280
aatcaccgat cattggggtt ttaacgtttt gcatgtttct tactccagtt tagtttattg 71340
ggttatccgg ttaacactct gatattttag agtgttaaca gaaaactcaa ttacccttac 71400
tgagagaatc gacttttcca aatttttaaa gagcggtgtt gcttattgag attctataat 71460
aaagcgttat cggcagactg tcaagcgtta ttttgtaaag attttaaata agccatcatg 71520
ttatcccaaa tcatcggcaa gccttgctga cctccgcgct gataagagcg gtaacgccgc 71580
gccatatcgc gctgcatttt gaccagttcc gaacttgcca ttttgttcaa ttttgctgcc 71640
ggtttagatg atattgcaaa gcgtttcatg ttgtcaacct ttaattagtg gagtgtatga 71700
tttcttttag tttgcataat gatttgcccg tctttatgaa tgaaagctaa atctacgtcg 71760
tacacgttta gataagtctc tataaaatgt tcggcgtctg ctactgtgaa ctcgtttaca 71820
atctcgctac tcattacgtt ttcttttaac atgttttcgg tttccttatt aagtaaagaa 71880
gccaataacg ctttttatag aatcccaaat tgttaaagag cagtgtaggg cggggacaga 71940
ctatacttgt ttcggccttt cctttcgcgg tagtcggggc aatgttgccg cctcctgata 72000
cctgactact agtgaaacgc tttcgtgttt cccgtttcgt cttgccgccc tacgagataa 72060
ataataacac aatggcgttt agccgcaagc ggagaattgt aaagaagcgt aaagagaaaa 72120
caggcccacg atagatagga agccgcgcgc acgtgacaca atatttaaag aaagtcaacg 72180
aatattttta ctatttttct tcaaaagggg ttgacaaaat ctatttcaca cgaggtgagg 72240
agatcgcctc atacccggta tgattcatcg gcttttatct aaaaccgctt agaatcgatt 72300
ctagagcgtt ttagaccctg ttaataactt atacaaaaag caaaaatgaa atttaattag 72360
ttatccacta gacaaatgat tatttttatg aaaacgcaaa ataatgcttg cgtttatttt 72420
atgctgtact cctgttttcc gggcaagtta tccacagcac aaaaataact tgacaagctg 72480
agaagcggta taacgagata tccccagact tatccacagg ttatcctact gtatatttgt 72540
acagtatatt ccggcagcgg taatactcta atatacccct agaacgctct ataacgcatt 72600
ctaagcgctt taaatttaga agccatatta aaggccattg ctggaggggg cgcagaaaaa 72660
caaaaagccc gctcattata agcaggctta ttattagtta gctaactatt agcggaatac 72720
cgtttcaatt gtttcgccgc tagagcatac cgacccgcca cgataaaaca ggcgttcggt 72780
tttatatttg gttagcagat catagagatc cagatcatcg gaaagcgggt aagattcccc 72840
cagcgcggaa acggaaacag gtttacccgc taccagatca cggcaaatca gaatcagcaa 72900
aggccagcta atattgatag catcgccccg caatccgatt ttgagggtag cgacttcatc 72960
aatatgcctt gcattctggc ggctaacata ttggatcacg gtttccatcg ttttatagtg 73020
agccagaaaa tatttgttga catagatgta aatcataggt atacgacccc gctaaccttc 73080
caaccggatt ttaaaccttc ctcaacatga aacatggttt tctccaataa tggggggcgg 73140
ctagagattc agccgccggg aaggggattt tacagcttat cgcggaaagt atcaagccgg 73200
ttgtttagct ctttaatcgc gtcggcatgg atttcgtcat acgttgacac gatatccgcc 73260
agctcatcca tagttagcga actaacaata acggacgttt tcacctccag cttttccggg 73320
atcgggacgg ctggtggctc gtcgcttatg gcaaacgtac cggagcggag caggaaaaca 73380
gagataccgg tttctccctc ctcgcaatcg atttcatagc tgctatcacc gatggacaca 73440
tcaaaaccat agccatacgt gccaataata ggcaatggta tgcctattag ctcgtcgtga 73500
tccgggtagc aatcgcggcg gtgaatttgt tcggctaaat ccgggccgct ttctttagta 73560
acgaaaatag acaagctatt actactacta gtggcttgca agtattccca aacgcgggca 73620
agcgtcattt tctcgccttc aaaagtagcg tttaactttt ccataacatt ctccagttag 73680
ttagcagggt aattattata gcgccccatt atagaggcgc tagatataat tattctgcta 73740
cgtcgttttc aatcaggcta gaaagattga cgcctttcaa tacttcgtca atcatttcgc 73800
ctacattgaa actttgtacc agttccaaca tggcggcttg cattgcagcg tcagccgcaa 73860
tcaccgcttt gcggttgttc ggcgcatact ggctaaccgc gaaattcagc aggttagcaa 73920
ttaccacacg acctaccgcc gtgtcaacat aaccgcgaac cataaacggc gctttgctgg 73980
cggcgatgcc agaaactttt ttcaggacga tagaaccggc ttccagtttg gcagcgttta 74040
cggcagcgtt tttgttagcg gcaacgatag cggtagcagt agatttgata gtattcattt 74100
gtaaagctcc agtctcaaaa ttattagggt taactacatt ttcagtaaca gccggggcga 74160
cttcttctag ctcgccatca taacgataat ttccagtcct tgccccttct tcgatttcga 74220
tatcgaagaa gttacagggt aacaggatgc taccgtcctt gtcaagcaca aaaatcatca 74280
tttcgctaga aattcgtgct ggtggtagtt ccagatgatc gcacagattt ttaacccatg 74340
cgcgggcatc agtgaaagca agcagttcgc tttcatggta gcaaaaacgt cgtgacgctt 74400
gcttaccctc ggacgcttta tacaaataag cgtccgtagt agtagacact atcagatcaa 74460
taggctggct gtcaaccaaa tattgatcat cgtgataaat aacaatcgcc gcgccggggt 74520
tggctagagc gtagtcacgg caatgctcaa aggcatagcc ggatctactt tccatattcg 74580
agcggtaaac gcccaaaata tgaccaatag aggcgcactt actgccgtct aacaggttgc 74640
gagcgccacc gcgaaccatc ggcaaattag caacgggggt aaacttctgt aacattttct 74700
gttactcctt tgtttggctg agaatctatt atagcaagat tctccgcttt ttagcaagca 74760
aaattttttt atgcttgccg ggagatcaaa ctatagggaa atcggatttg cctgtctact 74820
actaaaaata gtagttgctt cccgctagag ttatgttatt attactactc caaatagagg 74880
ggatcgaaaa atggcttttt caatgttggc gctcggttta gtcggttcta tgatggtttt 74940
gggctttatc gctttttgcg gctatgccct ctatgatacc ttgttcaata aggaggcttt 75000
ttaatgagaa ctttgcgcgg tggtagtccc aaaagccgta gcaacaatac ttaccaattg 75060
aacgttattc gtgacggtca gaagaaaggc ggtgacggtg gcggtggcgg cggcggtgag 75120
tggggttttc gtgtcatcat ggttattatt atgaccctag tctttttgca gagctgccaa 75180
tgatacttac aatcctattt attagcgtgc tatatatttt gcccggcctg ctggcgctag 75240
aggtctggtc acgatcaccg gttgactccg agcgcgaatt agagcgcgaa aaagcaaagc 75300
gtgacggctg cccgttgcta tagggcggct tttcctccac cgcgtgaccc cttactaaaa 75360
tacctccccc aaaattaaat cgcttagagc gcgttctaga gcgcttaaaa tcgatatcag 75420
cagaaagtgt tgctgggaaa tactgtataa atatacagta ggataacctg ttgataagtc 75480
tgttgataac tcgctaccga tcgattgagg cgtcaaccta atttacaatt ttgtataact 75540
ctggggataa cttaaatgat agtgtttctc acttcctttc cgaaatgcaa atcattctca 75600
ttcgcattca gcttatcaaa cgagaataat tatcattcgc attcaacttc tcaaatgcga 75660
atcgttctca ttcgtatttg catttccgac ccccggccct tcctgcgctt atgtgcgaat 75720
ccgacaattt gtcaagcaaa atattacgtg aggctgctag ggtatgtgca aatccgatga 75780
aaatttattt ttaccgccct gggggcatgt gcaaatccga cactaatatg tgcaaatccg 75840
atgataattt ttagggggaa ggcgcgcagt ttgctgcagc gcagcggtgg gcgcgagttt 75900
gggtgagtat gtgcaaatcc gatgggtatt tttgggggag ggataaatgg ggttaattgg 75960
ggcaattcgg ggatgatggg ggcaaggggg cagataaggg aaaatattat gagttaaatg 76020
ggggtaaagg ggttgacaca gaaaaaattc ctgtggctct aaaaaacaag cgaactcacg 76080
gtgacacacc gtgtaaaaag gcttgaaatt tcaggagata ttttataatt gcagaatcga 76140
agattttgat ccacagctac cgttcgttag agataatgtg catatccgac aaccatttga 76200
gtatgtgcaa atccgatgat gatttttata tgtgcatatc cgatgatgat ttttatatgt 76260
gcatatccga ccatgttttg aaattccaga aaacctggaa atgcctaacg tattaaatat 76320
ggacgagcta gaatcagatt gtggattctc tagctgtgtg caaatccgat aatgtttgac 76380
gcttaaaact tgggcaaatg atgtgagttt gtgtgggaac ttcgtgagga ttttgtggag 76440
tgacgcttag gacttgggca gctagcgttt taatgtggga aatgtgtgag gacttcgtga 76500
gatgtgtgga acttcgtgga attgtgtgag tttctaggaa ttgctttccg aaaaagtggg 76560
ttggaaaata accgccctcc ccttaggtgt gtagaaataa ccgccctgta tagaaagatg 76620
actagagttc aaccctagag ccgcgaaacg atggtgtgta aggattacct acttttaaac 76680
gtgagtaatc gtgagttcat tcccacgttt ccctattttc tccttagttt tcagtaatta 76740
ataattcccc ttagggtttt aacgagctat cgcacacccc ggctagcgat actgtgcaga 76800
ttgatcaatt tttgtaattt cgcactaagt gtcttgagtc gggacagggc cctgacactt 76860
acgaaattga aaaatcaata tctgcacatc tctagcggat gtgttaacta tctatttaat 76920
ctaacttttt tatcttatag agttattcta acatacatct caaataatgt caagaatttt 76980
tacgggagtg tttgaaaaag tgtcacgggg tagatgttta ccccgtgaac tcgtagacta 77040
cagttgagaa cgtaggttct ctaactcagt gaggaaggca ggattcgttt gatcgaaatc 77100
cttaatgagg aggtgctgat caaaggagaa ttcatagtct tctccgtaca gcttaatgaa 77160
gagatctgga tgttcacgtt tcaacacaac atgcgctacg atactcgggg taatctcacc 77220
ttcttgctgg tggtaatcga atagctgtag agtttcatgt ctagtttctg gtttagctgg 77280
ttcttctttc ttgatgcccc aaggagtgac aaacttagga tcaccacctg ggaagacgga 77340
tgctcgcatc ttataggcgt aagagttaag atctgtcatc ttggatgttt gccatgctgc 77400
aaagatttca tgtttacctt cagatgctct gactggtaaa taatgatcag ggtagctggt 77460
taatgcacaa cggaatggat caccgttata gttaggggca tgagagccat aaagtgtatc 77520
atgttttagt ggttcatctt ctataatata gagctcttta atctgcggat aagagaacca 77580
ctgattgaaa accttaacag cgaagcgatg tgcgtatggt gacatcttga gaacgtgata 77640
cttcgcccct agatcatctt ttgccgattt accgtcttct gttactgcgt aacgtctaca 77700
gaacatctct acgagtctac gctcgttagt tgtgagagtt gagtatttac gctggtgcag 77760
ctcataaagc tcctctagca ttccctccag cttggttacc atttcttccg ggtacttcgg 77820
gaatggtttt tctactgcgt tcagtacagt gttagacgaa cttttacgtg atctttgtag 77880
tgcattttta aatctgctca ttttctttcc tcttatagtc cattggactc tttttatagc 77940
cacgggattg tggctcttaa cttacttcat tccacctagg atgtgagaac ggctctctac 78000
ctgtcaagcg atccatcatc ttccggtgct ctcgctctct gtgttcatta aacacctgaa 78060
gagcggcgaa actgtccact ggcgtgtacg gcacgccgtt aactttgagg atatcctcgc 78120
ctctgatctt gaatagcggg ttgtcctgct gggccttagc gtggcattca ctcaagtact 78180
ctgcgaaagg tttgccatct tcccgagtac acagggtacg aagaaggtag ctacaattct 78240
ctccaaccgg agtccatact tcatattttt cgttcattgt gttatcctct tacataaaaa 78300
aatcttcatc ggattcggct atttctttat aaaagccgtg atatgctgat gttgcttcgc 78360
taggtgctgc catgtcgaat aagcgtgctc tttgttttaa ttctgcttta ttttggcact 78420
gcctaatcat ttcttcgact tcttgctgca agcgtgcatc tacacgaacc accagctcac 78480
cttggtgaat cgacccagtt ctgaaggtta acatcgtgag atagcctggg tgctgtcgag 78540
actttttgag aaccacgtta gtatacgctg ttaactcatg tacaaatact gcacctggga 78600
acgcataagg agttagcttc ttacgagctt ttactgcctt aacatctatt aaatgaaaga 78660
agtctttcgg agtcttggat atgtcgtccg gtacttctac ttggaactga ttccagagga 78720
tacgtacttt gctttcagac atgccgtaga caatgtacgt ttcgttagct tcttcaaaat 78780
caactgtaca gaataacata tcctagccct cttacttgtt gtagaactca gtagcgcgat 78840
tccacctctg gatgctctcg acatgggctt gaccccagat atttctggag ttagtcaatg 78900
cagaaacatg cggctgaata agttcgaact taccaacggt agccccacta gtcagcagta 78960
acgaggttaa cgcttcgaac ttaacggtat cgctaccgga cagctcactt actgccttaa 79020
ccttgtcaat tatagagatc atcttagcct cttcacccac gaacgtaaag cgcaggttgc 79080
ggaagcggaa ggagatagct gctacactcg gcttgctaga gtccggggag tagttcggat 79140
ggaacttgat ctcggagact gattggtcag tcagatagtt ggtgctcgga ttattcaggg 79200
aatcgtattt catctttaac ctccaaaggc tttatcaatt tactggagtt attataccaa 79260
ataatggagt ctccgtcaat tgaaaatttg tgatagtatg ctggcacggt gtaacttcca 79320
taatccgtaa ctctagtaac catgcggtgt ctgcattttt ggcaaccatt gccctcaagg 79380
tggcttctag cggtttgcat gaagtaatcc tgatggtctg ggcaccatat ttccaccagc 79440
tgatttaagc tgtgaaactc tagcttctca tatccgaaga atactccatg agcgtctaga 79500
gcacggttaa taaagatgag gttcttagca tcttgcctga aatctggcct cagttgcttt 79560
atcttattat ggttgatcga accgtcgcgt ttaaggaact gattaatggg gaaggattta 79620
gcttcccata ctagttcttg atttatcttc tgtcttaatt cttccactac tcaaattcct 79680
ttttcaacct ctcgtatagg tctctggatt gcttccagtt aaggtatact ctattaggtt 79740
gattacctcc cccacgctga gtaagtataa aacactcttt cctaatcttt tcgatagtaa 79800
ctgctgattg atctacagga ttttctcccc gtaaatagtt gtctatagat ttcatttaat 79860
atccttaaac cacgaaaggc cagagcaatt agccctggcc tctttgttag gtgaacagat 79920
ccagaaactc ctctggataa tcggaaggat ctccaaagtc gatgtgatct gcgttgaccg 79980
ggtagccttc tttcgtcttg atgccctgaa gaacatgggc caacacgtca aagtctacac 80040
tgctgttatc acaacaggta gcccaggctt cctgacggtg gacgcatttg ccatccacca 80100
taacctcaac accgtagcca gtattccagc aaccgtattc gcaatccccg gaatcttctt 80160
ctaggaagtt taccacaacg cgtttcttag acatttgtca cctcttagtg aatagtaccg 80220
tcgatgcctt ccacatggat atcgattgcc attttcagca tcgactccga tttatcaaac 80280
tctttcttcg aagccaggag tgcttcacca cgagctttcc catactctgc aatagcattc 80340
agggtatgtt tcaggatatc gtcggcggat aagccctgag tttgccagtg gacttgagct 80400
gtggcgatgt tcaccataaa cttactcagc tcaacacgct cttcgtctaa cgcctgcatt 80460
acgtgggttt tgcagttata gaaggagttc agacaaatgt cttcttcggt cagaccttca 80520
accagaagca tcttctctac ttgcgccagg cgatcaagcc acggattttg gagcatcaaa 80580
tttttcactt gcatggtata agttcccgtc gttaattggt gcgaatgatt ttgcgttgcg 80640
ttcaggacgt tgtttagcga tccagcccat catcatctgt cgcggcagta caactgctgt 80700
gttctgcagc acttcgtaga tccagtagcg tgcgttctgg tacttaccga actcatacgc 80760
tttcttgaat aagccccaaa ccacgctaag ctctagcgtc tctgcatttg cagtctgtcg 80820
gaacggtatc actttggaac caatgagttc tttcagagcg gagttgatat cctgatgact 80880
gaacgtggtc tcatggaact cgttgaagaa acgatagtcc agagcgttat tagcgttaac 80940
aaacatctgg atgaacagat cgctgaactc ttggtgctca tgattgaaat attgatttaa 81000
aacttcagtt gatgcggcca tctttccacc cgttaattgc tacaagatac atctcgtaaa 81060
tgaatacagt gactggttga attgcttcca tgtagaacgt cgctgggacg ttatggaaga 81120
ctgaaaccac catggagagg aacaatgccc agcctaggaa acggctgggg agttctcgcc 81180
agacctggaa gttgcaatcc aggaagttat agattcgaag atgattaagc attggtcagt 81240
ctccagtaat agtgacgagt attaaactcg aaaggttcgt cggtgatctt agtatgcagc 81300
gtgatgatat ccggggagta ggactttgcc agatctttgc gaaccatcac agtgttaaac 81360
ggagcaccat cagcacgctg aaccacaatt gccaagccta gaggaggaag ctcacacaaa 81420
ggacgccatg aatccttttc cgcctgggtg atttttctct gaaggtttac gaatagctcg 81480
tactctttat cagacatttc cccaccgaag tcagagtaat ggtctagagc ttctaacaga 81540
atatcacgct ctttggagtt aagattcatt tttcttcctt cttaatggtg ttttcaatat 81600
catccagcaa tgctgtgcag ttatcatagt taactttgcc cctgccaaag attctcaaaa 81660
cacaggcgta gtacccggtt aacagaattg ccagaggata cagaggaacc agcattgctg 81720
ccttgatagt accttttaaa ccgaagccgt ggtacttccc agacaggtag ccaacaacta 81780
ccaggtaaag cgctgctaca attggtgaga tcatttctta atctccgtga tcaaccgcat 81840
tttggttgtc ttcgacatgg tggaatcttg gccgattatt tcttcgatct tcgctaggcg 81900
aactaagagt cgttcagccg cagcagagaa ttcatcagcg tctcgtactt gatccatcaa 81960
tttttcgtgg agtccgttat tggtcaatct catcctgcgg ttagcttccc gcagtattga 82020
tacccaaacc gccagacccg ttccagttac gagggctgcc atcaacagcc cggagagaat 82080
ttctagtacc attacttttt cttcgccttt tcacgtttca ggtcacgttc gaagctctca 82140
gcacgacgct cagcaacctg ctggtgttct ttggcccaac gcgcctcatt tttagcgagg 82200
ttgtaggccg cagcattttt gttagtacct tcgtacagag cacgaagtgc cgggagagac 82260
agtttagcaa gctgaccttc gaacccatcc atatccagca ggattaccag taccgcaacc 82320
atttcgtctt tggtcagggt gttagcttgt tcgtcagcag ttttaccagt ggtgtaagag 82380
atagtgttct tagccataat gatttccgtc cgtttcgtta atttatgcgt atattatacc 82440
gaaattctaa ctacttagca agtgaatttt taaacttttt taccaatcga tccggtaagc 82500
gtaaacttca gaatgaatgt gctcttctac cagcttcttg atctctggcc agttcttttg 82560
aacttcatcc agaacgtagt cgtttgaagc atcatcccac tcctcgggaa gtttcatgaa 82620
agagcctgcg tactccagta cgctctccag aacatcggtc aggtaaacta tttccccacg 82680
gttgcagtaa gcgtgttgat aatcccggcg atcttcatta aatggggagt cgctgaggta 82740
atcccccata tgaaggagtt catcggcgaa ctcctcaaat accttgacac gagcagacag 82800
cggtatgctt tcatcacgca tcagcaggtt aaaagaagca cgtgcagtgt taactgcgtg 82860
gcgaagggac tccatatttg cattcagttc gatcattgcg tttttcatat ttgcttcctc 82920
atcaatttat aaagctatta tacagaaaaa ttggctcgga agcaactgaa tttaaaatac 82980
aaatgctacg agcgcccaga ttccgcctac aattgctgca ccgattaatg cagctacgat 83040
cagaaggcca ataaacatct tggccatatc atttcccatt ccagtataca tggttactcc 83100
tcgattacca gtcttctcat gtagtcgttc caccctatac agaatggaga aataccccgg 83160
agtagttcgg tagactggtg ctgcttatag tggtcttctg cagccttagc cccgcgtttc 83220
ttctccgccc ttttattaaa ctcttccagc acaatacgtc cttctagagc ttctttagcg 83280
ataggatact caggccaatc ctcctctaga acgaggtagt ttggaaatcc tactttcccg 83340
tccgcctctc gacttttaga gatatgggat aggatgttgt tcagcctctg aatggaggtt 83400
gaatccagat atttttgggc atctttatgt ttgatgacac tataacgagc ttcaagtttc 83460
atgtgctacc tcaggctgtg aataaaaggt cttccattgg gcgatcttta tggatcgccc 83520
agaactcttc cggttcccag gtttcagtgt ccggggcaac cagaaccgag atattcgcgt 83580
catctgtaaa cacggagttg ccattgtcca gcattgcgac acatttctgc aactcgaaac 83640
caccagcaac tacgaatact tcaccttctt ccaaatcttt gaaaagtttc atgtttcacc 83700
tattaaataa tgtcagcgga accacaggga tcatcacgat ttgtggtgaa tgtgtataat 83760
tgacctagaa ccggcgacgc cacggtcatg cgaccgttaa aggtgccacc tgtgtccaga 83820
tagacacgat tcttccagcg aattgggaac gggacaccag tatggccatg aaacgtgtag 83880
tctactccta cgatttcagg aacatcgact gcgcactcct tggagaagct agagtagcga 83940
tcgaagtacg ggtgcttttc cccactacga tacagattaa acccaacttc ctggattaca 84000
tcacgatccc acagcagtac atccaaacga tgtagaactg gggcagattc gtgttcatac 84060
acaatgtcgt cccacactgg tacagttaca cccatacctt gagcctggta gcgcagaggg 84120
ataccagcat gaactacccc gtagcgcttg cctcggtgtt caaccgtcat catgtacggc 84180
atcttgctgt ccatgtcctc tgcaatacct ttcagggtgt ccgtatcgaa accttccgta 84240
atagtccagc taccaccatt atacatccag ttggcgtagt cgtcttggat catgaattca 84300
tcatggttcc cacgaacaga gcggaatttc gggttgtaca ggaacttcgc tagaacctgt 84360
aggttcttcg ggccacggtc gataagatcc cctacgcaga acacgtagtc acgaccttct 84420
tcatacccag caagtttcag ggcatccatc atcatatcgt actcgccatg aatatctcca 84480
atgaagaaga tattagcatt gtcgggtacg gtaactgttt catgaacgtt cattaatacc 84540
tcgtctataa atagtaacgt tttggcagcg agaagtctga gggctgctgc ctgtgatctc 84600
ttacatattc ccctcgataa gggtcgtata ttacgtattg cactagacct tcgggttccc 84660
aggcaatcag tatttcattg cctattcgtt taaatgcgta cccattctgc ttagcccaca 84720
gtatgcacga gtagtccaag ctcctggcat ctacttttat gccagaaaag cccctctcta 84780
cattgtaggt gatacccttt attaacttat cgagctgcat tttcttatta tagtaggcag 84840
cagctcgatt tttacgggcc atatcagaag accagtctct agagaatttt tgcattatgc 84900
acactccaca tcgtcgtgtt catagccata gttagtgcag gtgttagctt catcatcgtc 84960
cttacagaac gcaacgtagc agtctacaac ttcccagaac gcttcgttga tcaaagcatt 85020
ttggtgagtt agatctaatt catcccactc ttcttcgctc tggaagtccg tatgtacgtg 85080
agcatcacaa cctacagcgc ctagagatac gacaataact aactcgtcat ctaccatttc 85140
cacgtaagcc tctgcatact cccaggcggc ttcattaaca agctgagtct ttacttcggg 85200
gctgagagct tgccactctt cttttgtata ccccagatca acgaaggtag taccaactgc 85260
aaaaccatta ttcaggataa gatatgcttg cttagtcatt atgtgatcct ctctcaattc 85320
aatataaata ttatatcaaa attttaagcg tttagcaaat aataaaaaac cccggtctcg 85380
tattgagccg gggttaggta ttattcttct acgtagtcga taaagtcttg aatagcttta 85440
ctaactactg cagagcgaag cgtggcacca ctcagaatgt gatgtgcttc ttcacgtccg 85500
ttctccacat ccaccaggac tactgcgggt acagtgcgaa ggccgaactt acgtagggaa 85560
tctacgtcgt ccgtgcgttt ttcaacgggc aggttgaact cagcggtgag cttatcaaaa 85620
acaggttcaa actgcttaca aggggcacag ttagaacctt taaggaatac aatcttctta 85680
gacattatta atactctcca atagtgtttt cattgttttt acggttgcgg tatccaggtc 85740
tagcttttct ccgaaagctt ccattacagc ttcctgatac ggctttttca gacgaccctc 85800
aggtactgct acttttttaa catctcctgc cttgactttt gccaaaatag tggttaaagt 85860
tggcatggaa agtttctggc ccccaatgtt aacgccgagc agttcggtta gcgcattgtt 85920
aaggtcaatt cgggtcattt tcttaccgtt ggacataaca ccctccgatt tcttagcaat 85980
tttcttaaac tccggtgact cacgatcccg cagagctata tttaactcgt agggagctac 86040
tttaaaatgc tcgcacatct gagtgtagaa tctgtccgac attttgtatc tcctctctcg 86100
aatttataaa tatattatac gctaaatcga gcagaaagtc aattgaattt ttcattaatc 86160
gcagtacttg cctcgtctta cgaaaaatag tgtaatggga tagactgagt acatcaacac 86220
aggagaagta agggttagga tagacgtcac cccacctgcg tacattagcg gtataaatgc 86280
tagcgttata gctaggacta tcataccgaa caacaatgcc aaggacaatg agaagcaatt 86340
ctctagacct aaccagagcc agcaaaaccc tgtccctctc tttttctcac atggacagcg 86400
aaacacacca aaaataccaa atacgaaatg taggagccat ctagcaaccc tagctaagcg 86460
tgttctgcga aaataaatgg caccgcgtat taaaatccat gatgcggaaa agaatactat 86520
accaaattga aatatcttga gtagcattat agttactaaa cttgcaaaca taatcacctc 86580
ctatttgctt gctccataca aagaagggga gcctaaaagc tccccttaat gtcacagtaa 86640
ctctacgtgt ccgccgtcgt agacaccacg ttggatttca tcacggtagt cgccagagtt 86700
gttccaatcc gctccgaaac gaacggcgat gttcatttcg tttgcggcct ttttaaatgc 86760
accgacaata gcccaaaatg cttctaagtc gttccagtca atcttaccat tgatatacgg 86820
agcgaaatca atggcctttc ccgtaacgtg cttagacttg ctagggtctt ttaaaaatga 86880
ggtgccattg gcaatattct gggcgctctg ttgtacagta cgtttgccct gaatgatggt 86940
aaaatcgtgt ggtgagagtt ccagagcacg aatagccaga gccttaagtt taggatctac 87000
agtatcgagc tgctggagac tacggtttcc aaatctgaaa ctcatattga tctccctagt 87060
gatctctgcg gtgatgcgca gatttttgcc atatagtcat taaacatgct catgtcttcg 87120
tctaatagtg ggtatttctc ccacgcgacg gcaacatatc cagcgtagat gttattaagg 87180
ttaaaatatg ggcacgtgta cacatactcg aaatttgcac tcttgaacgg tggcaaaccc 87240
gttccagacc acttcgataa acctcgtttt tcccttgcat caattgcaaa gttcagaccg 87300
tctaaatgcg ctcggtagag catagacgtc ttgtcaactg ctttgtcgga tacatcggat 87360
ttatccaact gaacgttgct ttcccaagct aggatagttt ggtaatcatt tatagcctca 87420
ggcttgtatt tgaccacgaa gacggcatca gctcgagtct gtgagaatag gatcattgcc 87480
ttctctcgtg ccacatttgg aaactctagt gtgcgttgta ctttaacatc ttgtaggacc 87540
gccgaagtag agaaagtctt taagtacgac atgacttcac tcgtattagc tataaagagg 87600
tagataacta gaccaaccag taaggttagc aaacgtttaa gaagagaagc tggatccttc 87660
gcttcttgta gtaacagcga tatcaactgt ataaatttat ccattaagaa cctcctctaa 87720
ccatttataa ttataccctt tattggagga agttgcaata aaattttata gttattgctc 87780
ggatcatact ttgggacaaa tgtcaagtag aatttagata aagaaaaagg ccagagctaa 87840
aaaagccctg gcctacttag ttttattgac ccgcagcttt acgagcttct tgctctcggt 87900
gcgcagccat acgatctaca cgttcgttga tttctttgga ggtcagccaa atatccttac 87960
caccttctat catctcagtg atctcttcta gagagaagaa cgggtagtac aggtctagca 88020
tcatatcctc aaagaatgag ttgaactgat ctgcatagtg ctggatctcg ttcttgccct 88080
taccgtagtg cgcaccacga taagtatggc ccatcaacat aacgtaaggg tgcaccaacc 88140
agccgtggca ggctaggaag attgagcagg cagctgatgc tgatggccca accagatgcc 88200
caataacggt tccctggcag ttcatgataa ggttgcacaa ctgaactgct gtatcaacgt 88260
acccgccggg actattaata taaagattaa gagtgtctcc ctcttgcata gttgccagag 88320
tgactgatag gtcgcggtag tagtctacat cgactatcgg cccatcgaga tgatagtggt 88380
aaatattata ctctgcctta gtcgccacca gggaggcgaa gtaattagga gtcttattgc 88440
cacttttctg ctctacgtta ttaatttgtc ccatattgtt accttatata aagagaatcc 88500
tctcgtcgca aaacgcgttt acatttttac ggaaattttc cagtccgtca aagttatttg 88560
tgaccacatc atcaataaac tcaggtgcaa cacctctagc ggaggcatga gtagattgga 88620
tagcgtggat gttgttaggg gcgtgaactt taagaatact agagttctgc gcaccgggga 88680
agttccgaac tagagcggct tcattatcaa aacgaacatc agaaataata ctaatgtcag 88740
ctttggtagc agtgatacga tcgaccacaa tattcaacca caagttctca tccaccagag 88800
cgcgtcctaa ctccgtgcca acaaattcta gcattttacg aggggacgtg tataatgggt 88860
acagcggggt ctcgtgaccc tgataaaagt ctggagcagt cttagcaatc agcggatata 88920
gcgctgacgc ttcaaactga ggccaaacgt aggggaaatc ggcgtacttg tcgatcccaa 88980
aacgcttcca gacgttagca gtacgctcaa gggcttcctg agtcacccaa aaccactgct 89040
taatctcttt tgtcctgcgc tctgccagct tttctggcgt gactccaagg attacagccg 89100
cgagttcgta aactggagcc gcaaaactga atttactgat agaatactcc ggaccgagga 89160
cttcccaggc ccaaacctta gccatgtcag caaaggtgtc tttgcctgcg ccggcatcac 89220
caactaatcc taaaacgtat ttcattttgt ttccttattg aacggtttgc aacggtattc 89280
attaagtgac acgcgatagg tacacgttaa tgcagtcaga ttggcaatgt aggtgtagac 89340
ctgctcatta cacttgccca ttgtgatcca atcttggtaa ggtatgcgaa catacacttt 89400
cccttcttcg tttatgaact caaaattaaa cgggcaagtc tgtaggcttg ctggccacgg 89460
taggtgttgc ggctctatcc ccgttactgt gctacttggg tctggccgtt ctgcacaccc 89520
ggatgcgatg attgcagccg agagcaggag tccatatttc cagttacgca tgaaagtctc 89580
tcctggaact cattaacttt gtcttttgcc actttggtag caagtttagg tttagcggca 89640
accacgccct ctttggctct agctgcatcc agtttattaa tacgtccatc cagatcttcc 89700
tggttcttag ctaggttggt tatgtaggta gtggtgttgc gatctcgatt tcgaatctct 89760
gtttggagat taccaattgt cttttctagt tgttcattac ggtttgatag ggactgtaaa 89820
gaactggaca tatctgttag cttattggtg atgtagtagg caccaccgaa ggtgcctgct 89880
gcaattgcca gaaacagaat tgctccagtc ttaccgctcc atattcctga aagaaacttt 89940
agcatcgaag cccttagcaa ttaaccgatc acgatcagac gtagattcgg tctttggttc 90000
cccttgaccc agcacaccga agatatagga ttctaaggtc tggtgccagc gatacaggtt 90060
tggatcaatt tcctgccacg ggaaatcttc cgcatggaag ttgaaatcag ttttaacggt 90120
aatgttaacc gttgggtctg tcttagactt tgcagcatcc catgccatcg caatgggctt 90180
gttgaaggtc tctaggaacg cagaagccgt agcagttgcg ttacgcacgt aagcgtcaat 90240
cttttcgatt gtattagttt cccaacccaa acggacggat aagccctctt cttccatcag 90300
ttcgataact ttggcaggct cgaaggtctg gaagtgatag ccaatccagg tgttaccacc 90360
gttagggcgg tatgtatggt acccgtatag ccaacgcaaa gtaccacaaa ttaataccgg 90420
acgaatctct agggttccca cctggtagac cccaaactta ccgttcttca cagtctcaaa 90480
cagattggca tagaaaatga tctgttcgaa atctgccggt acattcacaa cctgcttaat 90540
ttcttcccgg tgccaaacgc gttctgcgtc gtacatggtg ccctgcaggt catatacatc 90600
tttaacttta gagataatac gcatctttgt tctcctctca tttataaaac cattatacaa 90660
cattttaagc gagagtgcaa gtaattttta aaaaagaaaa gcccaacacc tttcgatgtc 90720
gggcttgggt agttagcgat ttaacgggtg atgttccaca cagtaatcgt taaagatctt 90780
ggctcgcttg atgctatccg gtttatactt agcgaacggg cctttcaaag ctccctgtag 90840
gatgaaaata gccttacaca gtctgccgat agtcttgcgg ctcatacagc ggagttctac 90900
ggcatgctta ccattacgaa gctctaggat cttatcgaag gacttcagga cacccgatgc 90960
atctttggca ccgccttttg cgatgatggc ctcgatatct ttacgggtgg caaactttgc 91020
caggaactcg aaggctttag ctgacagcag cttagcagag tccagaccat gattgatacc 91080
aactgccatc cacgctgata ctgccaggat aaataaagta aacattttgc ttcctcagtt 91140
tgtctttgaa ttagttaatg gtcggcgacc aactcaccac ttcgttcatc gcgggcacga 91200
ctccggatag gaacaggaag gtgactccta taacggccct accgttatac gtgtggattc 91260
atgttacaca tcatccgagt cttctctact tcccgccgtg ctttgcgacg ttgccgccgt 91320
agcttgtatt cattttcaat gaccttatgg aaatgatcat taatgttatc ttccggcaac 91380
atcaaacgaa ttgttgccaa ctgctcgatc tgaacccgaa gatgggagtt aggcatacaa 91440
agctcttgca tctccacgaa cccggataat cctagcgcgg tcatagaggc tttagcgtat 91500
actttgtcct cttttagact taactcaacg gttatccggt agcgagagtc aaacacagta 91560
caccactccg agggtactgc cccggctctt gcccagactg aataaggggc ttcctcaaaa 91620
gcgcactctt cattaatcca gtctaggatc tcttgaagtt tggggtgaag attactcatc 91680
gctatcatcc tcgtcttcta cctgacgacc atagcggtcc agtgtcacag cgggcttgcc 91740
ataggttttg ttcgtgtaga tcttagtttc cccaaaacgg gtttcagatt tacgaaactt 91800
accagcttct ttagtaatcc cattcgttgt tacacgaacc cgcccgttat cagagatctc 91860
tactttgtta cgctctgcgg ccagagatac tccagagtac atcatactga atacgatgat 91920
tgctgcaatt gaacgcttac tcatagtctt caccttcgtt atcttgttca tccacttcac 91980
cttcgaggtc tggctcgcag tcccggcaga tttcctctat ttggttctcc gccctttcaa 92040
aagcaggaca ccaccaccca caattcacgc acctaaagat ctccatatct tccgcggtct 92100
gccagaagag atcctcgata acaccttcgt gaaggttata cccgttagcc accagctctt 92160
cttcgataac attgagagct tcagtttcgc ttacacagga accttgtaca tacccgtgca 92220
ttaacgggcg gataatgctt tcaatactta gtttgctcat gaagctctcc ctatcaattt 92280
atgtaactat tatatcgaaa aatcgcctac agtgcaactg aatttttcat ttatgaactc 92340
cagctacact taggacacgg gcaggacagt gcgtgtacgc acatcttgcc gttcttatct 92400
acaccagtac catgacattt ggtacatgct gcatgtaaac acactggtcg ttgctcttca 92460
actaacttct taataaacgg agcgctttca accattttac acaattcttc gtgagagtat 92520
ccaagacctg tactaatcat tttctacctc tgcgtttcgg agtgggccag gaattagtct 92580
tgccgtgagt aacctcctgg cgggagctac gtggcataaa gttattaccg atcggatgtt 92640
cgtgttccat ttcccgagcg taggattcta actctagaaa gctggcttgg gactctcgtt 92700
ccattctttc tagatcagtg aagctgggaa atccgccgat tccgccgtag ccaataagca 92760
ttattttcgg cacttcgaca ttacgttctt ccagtcgttt acgaacaagt tctattgctt 92820
cccgagcaat tttatcgtcc attgcgttcc tccttcggta agtaatcatg cagctctaca 92880
taagagatgt tctttctttc tttatactct ggcttaccat acataccatg cacttctact 92940
actttggcgc gacgaggatt attaaacata acattccccg gtatgactac tacatcacct 93000
atctccgggg agtatttcca ataactaggt actcggtaaa catatgttct gttactgttg 93060
gagaacttaa ttccaacgtg gcgagtagtt gaagccatga tataaagcct tagccgcctg 93120
ccgcggcatg ttaagttttt cagccagttc agaccagaag tctttgccac ttaccatgtt 93180
atatgctacg atgttcccat cgaaatcttt gagacgctcg gcctctgcct ctaaagctgg 93240
tcggttcttc tcaacttcga gctgaaactc gttcagacgc atgaaattac ttttgtcgcc 93300
tagaaaacgg acgtaggctc cggctacgcc atccaccgaa gatgcaccgc atttacaggt 93360
ctgcatcttg tggtcgacca attccagggt gtcacggcag cattttacga aatatacaac 93420
tttactcata atcattatat ccttcaactg taaaccagcg tttaacttgt gtgaagctca 93480
cccaaatacc ctcatttgcg tcgctccgta ctttgtaccc tgctctacta tcatgtagtt 93540
caacgaagta gagcttaccc ggagtgaagt attgaaactt gtgaccacca acaattttat 93600
actggaggcc aactccagga gtgaagcgta agagactagc tttcaccatg tttcttctcc 93660
aggcgttttt cacgcagttc ggcttttctc ttagctacac gttcacgcag tgtgccgtgt 93720
tccttctcat aacgcaggtg atgcctgttg aaatcacgct tcatacgaac gttataccag 93780
tactcttgac tagcaatgaa gatcgccggg cgggacagtc taggaacatc gtacagctcg 93840
aacatacgag ccatttcttt atactcggca tggttcataa cacgatcgcc tggagcaatc 93900
tgattatccc aaacccactt ttcgtgatcc caatccgtat agaacgctcg gatagtgcca 93960
ggagttacct cgatttcata ccacgctgtc ttagatacac gatcgtgata cagacctggg 94020
cgattaaata ccggattacg ttctttttct cgccaattat ggaacgtacc gtctagtgct 94080
tgctcaatag tgcgtcgtgt tgctttgccc cagatgtaga aagagtcaac aaggctagaa 94140
cgaaagactc ggataccacg taaagattgc ttattcatta tttgatcccc aatgcgagaa 94200
gatggttaga cagtctatca agtgcttcca gagcagcttt gttgttttct ctcaggttgc 94260
taatagtcgt ctggaggcta tcaataacaa agtcccgaac tgctaactcc gcagcgattg 94320
cggacttact attaagtcct tccgcggtca ttgcgttgac atgtcgggta taataaccgc 94380
cagcgaaatc cagttcgtca atagcacgtt cggcgtaatg caattcatta agttcattga 94440
gttcgttcat tgattactcc ttatccatca tttcgaggcg ttctttgacg tataccagcc 94500
tgttgtgttg ttctttagct aactctgcta atctgtagat atccgccact aactgcattg 94560
tatggtcgtc cataccttcg ggtgggagtg tatctgcata tgcagtacag atagcgataa 94620
actcttctgt gttttccatt gttactttca tcttggaaac ctctctcatc aatttataaa 94680
tctattatac ggcaaaattg gcatttttgc aagtgaattt ataaagaaaa agcccctcgc 94740
tcaaagagac aaggggcttt tgtttagagg tcaggaggtg cctcagtgtt cttttctaag 94800
gatttttgtg ctctcagaac aatctggttt atttgctcca gagagtcgaa ggaaagctgc 94860
aggccatgac cttcatcggt ggcttgtatg aataaaactc tcttagaggc gtctacgaag 94920
acttgaaatt cttgttccac tttactctcc aaaaataatt acagagcact ggttttctct 94980
ggctatacga gagatgtaac cgtttacgct atgcttaata gccaagctag gttcgtcaaa 95040
catgatgcag ctgaatcgac gacctatacg gtaggtttct agcatgctat acgttgtaat 95100
tttaacatga ggttgaagct cgttatactt cttctctagg cgtgccattt cacggacacc 95160
ggatgctacg tatactgctt gaataccttt aaatactgca aactcatagg ctgtattaat 95220
agcctcgaac gtcttgccag tagctcgtcc cggattgact gatagaggcc aacgaaggtc 95280
aagttctagg aacctgacca gttggttgcg atctatgtac atgctggctc cttaaaccaa 95340
acaatgcgaa aacctgtctc gtcctctaga gcctgtacga tttgctctag tgtcagaacc 95400
ttatcggatg aaaatgtcca gagaaactgt tggagttcat cccaagactc ggcctccata 95460
atcggaacac cgatttctcg gccgaagtag tcatcagtac cacggacgtc aatacgacca 95520
ccggcgtatc gtttagcaaa cactttgcga gttagttgtc ctccctctgc aaaacgatta 95580
ggctcggtta cttccgtata cggaataccc atacgaatgt accaattgtt ggagattggc 95640
cccataaaat tggtgctata agtgatcatg atcactcctt taaactggca aaccccagga 95700
gactcgaact cctactgcac ggttttggag accggcgtgc tgtccagtaa cactcgggga 95760
ataaaattag ctaccgtggt agacagatac tgtcttacca ttctgattca taacgtaggc 95820
tacctcatct tctttcagga agatatgctg atcaagacca gcaatagaga tgctcttctg 95880
cttaggatta aacccaacgc ttgaaccatc gtgaatttct tcgccaccgt taggtgacat 95940
tactttaact gttaacattt gcttctccta tagtttgcca tctctggccg ttaagtgacg 96000
tcctggctga tatagagtcg agttccaggc agacgtcggc accccggact acattggctc 96060
tagaacagca aataatttaa gagctaaaca tactaagacg tagcgcacgt acacgatcta 96120
cgcaggcttc catctcagct aagagtgaga acactagttc tgcatcaaag gctttcattg 96180
ttgtacctct caagtagtat cgataaaatg gccttaccgg ctcccagttc cttgtttaat 96240
tccccgtaac gtcaggggac ggtcatttta ccgaatttgg agcgactagg gggaatcgaa 96300
ccccactcag taccgcttgg aaggcggacg ctgtaacccg tacagttaat cgcgaagtct 96360
tgatgaggat ttattcctcg atcggaacgt tggggtcata gaatggcagt tgggacacag 96420
tatacgtaga ttttctgggg tacagttaga ggcgaccccg tcaatatggt ctacttccgt 96480
taatactgct ccgtctactg gatgcctctc atcccaacca caagattcgc acgccgtacc 96540
cctagtctcc cagagatact ttcgtacaaa ttcttttatc tgacacgctt ttcctgtgta 96600
gccaggctct tctccggcta accactttct tactttctct ttatgctgaa atccatgctg 96660
gcaggcatta ctacaatact tacccattgt attctttttc agcggcttaa ctatgccaca 96720
attaaggcaa gtgaactctg ccattatgtc tccccaaatt ggtgcccctt gatggaatcg 96780
aaccaccgaa ggctgattac aaatcagctg ttatgccatt taactaaaga ggcaagattg 96840
gtctccccta agtgatttga acacttgacc tgacgctccc aaggcgcccg ctctgccaga 96900
ctgagctaag gggaatttgt atagttatgg gagtaggact cgaacctacc atcacctgtg 96960
cggaattacg agaccattta tttacggaat cgaaccgtat ctcaacccaa gccaggccgg 97020
cttccccatc agtcgtgccc cgtaatttgg tacccactcc cggactcgaa ccgggaaccc 97080
tgaagtctta agcctcatgc ctctaccaga ttggaccaag tgggtgttaa tcgttatcca 97140
agtaggcttc tatagcctct agggcttcca gagtagagat attgaatctc tctttaagca 97200
ctgccaccag agtttcctga ttccaggaat atactgaatt aatgtagttc tcgatgaaat 97260
tagagtagcc gcccattatt aatatacctt gattaaagtg ttatcgatgg tgttcagaaa 97320
cttaactgct gcgtctcgat tggagaatgt ctccagcacg ataatgttat tttcaggatc 97380
accgttacgt actctgatct ggtacgagac aattacttcc cagcgaaacc ataaagctcg 97440
tgggttatac cgcaaaagaa ttttttgatt cattaggtaa gccctctcat taatttatga 97500
atctattgta taataaataa gagcgtttag caaatgaatt ttagaacttt cgggaaaatg 97560
ccaccctcag tcgatgccac tgctagagac gttataggca atctatctct agctgtctgc 97620
cccattgctt tcagtgattt ctgcacgcag aaactcttct tgactggagg actttaccac 97680
gtcaaacggc cggaaatcag tggcttgttt ctccgttcat tcatcaatcg tttgtccgag 97740
tttaatcgga gaaccaacta acgaactact ttggatttgg tgcaaccggt tcgattcgaa 97800
cgaacgaccc ctggactttc aaaccagtgc tctcacctcg ctgagctaca gttgcgaaat 97860
tcatgcctgc tcctttgaat caagaagtcc accccggtct ttgggtcttt gcagtacatc 97920
acgctgctct gatgtttggt agaccgcccg agactcgaac tcggaatccc cagattaaaa 97980
atctggtgcc ctaaccaatt gggctagcga tctataattg gagcatcatg aagtattcta 98040
aacttcctta gagggtttgc aagcctctgc ctagtcactc ggccaatgat gcattgttta 98100
attagggcgc accggagttc caccgattgc taacgcttca ctgcaaccta agtcgctgtt 98160
cttaccctaa tactgtatta ctgactagga ttttcaccta gacggagtta gcaccgtagc 98220
gtgtagcggc atacctctcc aaaccgggcc acatctttca atttcggtgg cagtattcct 98280
acgcgtgcct gagttaatta aataaccctt tcagtaaaat tggcgggaga ggtgagattc 98340
gaactcacta tcattcgctt aacaggcgac cgcctatacc acttactgct tctctcccaa 98400
atatatttaa caaccaaagc gctttcgtcc atttaagcta caaggccttt atgccgcctg 98460
ttgcgtacgc gggattcgaa cccggatctc tttgattgtc aaaattggtg ggggaagatg 98520
gagtcgaacc acccgagccg caatggcaac gattttacag accgctctgc taccacttac 98580
agaatattcc cccgtatttg aagaagctct cgtgagaacc tcttcaaata cctcgtcgaa 98640
acgagatatt tgctaactta ttgtgactag ggctgaccct tgtgtccgag gatacctcta 98700
gacggtcata tctcttagcc cagagagaat ttggcgcggc taacgggatt cgaacccgtg 98760
gctccgacgt gacaggccgg tatgttgacc gctgaacacc atagccgctt aatttgttat 98820
tccggttcgt actccatcag atcatctgac tcacatgtcg gacactccca atggcattca 98880
cttaactctc cgcaatcgga acaaatgtat aacttaactt cctcttccat ttgcatttgc 98940
ttttcctctt tcgtttcaat ataaatatta tactaaattt cagggtacta ggcaaatgaa 99000
ttttttcatt aatcgtcttc ttcgtcccat gagagggagt gcatgaagat cggtagaact 99060
gtaggctcta cgtcaagcga cgggtagaag taagttttac cttgagacag atcaatgaac 99120
gtaggagttc taccctcctg catgtgttca tcaaccttgt ctagggcgtc gtttaacagt 99180
tcgaagcagt cagtattcgc tccgcaaaca acgataaaat ccattaacga cccccgttcg 99240
ggaaaccgga ggcaagcagg aagcgaacaa catcttccag cgacgggcct tcgccatctt 99300
cttcttccag atggaaaggc agaatagcat actgcatgtc agctggtgct accggggtga 99360
aggtaggctc tgcgggagct tccgccataa atactgcggt tccgtcaacc aggcggtcga 99420
tagcttcgca aacctctagc tgctcttcga tcttggcctc acgttcgcgc atcagagaca 99480
gcatctcagt gcgatactct tcgatacggc ggtctagaga ctcgatgtta ttggacaggt 99540
tatcctgtac aatcatcagg cggactacag cagaatttcc attagttggt cgtgtaaaca 99600
tgatatttcc tcgattgatt attagataaa gtcgccggta gagactacca gtttaatgct 99660
tttacggaag acttcgttca taccgtcgtg aaccattact gtcccgacca tttttggaag 99720
atagacttcc acgtcaatag ttccgtaggg catagcgtgc tcgtcagtaa gtttagtaca 99780
taactccggc tgaagctcgc agttatagaa caccatccac tcatgatcgc catcccatcc 99840
gtcccagtta agaaccagtg cggattcaat acctgttgca gtaaccttcg acatttgcta 99900
actcctctca ttaatttatg taactattat acagtaaata agagcgttta gcaaataaat 99960
ttttgaatta tccgctccga agagcggtaa tccaggcttg cagctgttaa ttgcacttgg 100020
tttgaagttg tctaagacat taactgaagg ttgatagcct tcccgtttct gcaattaaca 100080
aatcccaact tgtttttaac gtggatgctt gggtattaaa ggaaccacta cgttacacac 100140
tagggccgat tgccggaacc tagtcactaa cgctagggca atgaccgtct aagtccctag 100200
attcgccatt tatactcctg gacggcatgg agtcgattcc ctagactttt actcagcatt 100260
gcgctaaaac ctgtaaaggt aaggatgggg tattcttacg aatctgggat catccccatc 100320
agaaattaca gcttctcgga cgtttgacgg ccctgaccga agtctcactg taaattggta 100380
cttgctgctg gtttcgaacc agctaccctc gccgtgtaaa gacgatgctc tcccgattga 100440
gctaagcaag tatttggtgg tcaatagtgg actcgaacca ctgtagtctc acgtatgaag 100500
cgagtgcata aaccatctct gccaactgac cttatttggt actccgaact ggactcgaac 100560
cagtgaccta acgattatcg gtcgtttgct ctaccaactg agctatcgaa gcattattgt 100620
tcttgctgac ggacgcagat ttcctcgtcc gggtgtattt gagctattct agcatcttcc 100680
tcagcttcct tgtacgtgtc atgaaaagcc ggtgcccaaa atacgatctc ttttgtgtgg 100740
gtattaatta gcataccttg atagcgaatc atagttacct caacgtttac cgtttcgtgg 100800
tgctcctgga cgtctagcag cctctgccat tcgtttcttg actttcgcaa tattttctgg 100860
tgtttgttct ggcttgtgta agcccgccac attacaccac tgatctccgt cccaggaggt 100920
gatcaataat actccactac ctaaaacacg ttctgtgaaa gtgattcgca tcatcttctc 100980
ctagaattgg atgctccggc aagattcgaa cttgcgatct ccagcttatg agactggcga 101040
ggacggcctc tcctctacgg tgcaattggc aggggcaaca agaatcgaac ttgtgaccta 101100
aggcttcaga gacctccgct ctacctactg agctataccc caattatgcg cactctgctg 101160
agtacaacgt tgtgtctagg gccagaacat aaatgcttgc atttatggga ggcagctaga 101220
agagggatgt gacccagagg gctaacctcg tcactctcag cagagatttt atggtacacc 101280
atcgaggaat cgaacctcaa ccatagagtt cgtagctcta tattctatcc attaaactaa 101340
tggtgcagta atctggaggg atatcttgga ttcgaaccaa gatagactcg atccacaatc 101400
gaggtcatta tccagttatg ataatatccc aaataagtct tggcttatat gtgttgccac 101460
atacaataca tctacctaat tcgtcaagaa cataattcgt ataggctacg agtggtggag 101520
ttgactgtat cgtgtagagc gttagcctat ggctttcttt tcgctcacca aatttgagca 101580
ccatcgaggg ctgatcagac ctccacaaat aaaatgtaca tcgcacacat tatctggtta 101640
gacatatcta gctgcaatcc ccgcaagaaa cacagcgcaa tgctcgactg taccgatgat 101700
gctcaaattt ggcggcccta agaaactctt cccactcaca actagttgat tacttctgga 101760
ttttagccca gaaaattctc tagaaagggg caaccgttac tcgtcgggcc attgtgaatg 101820
ggctggtctc tcagccccgg ttactacttg atccttacga tctgacggca accacgtgca 101880
gcgacccttc atatattgta tagtgctcag aaggtcatta gaagcactac aactttcgtt 101940
gtttggcgga aaacgtagga cttgaaccta cataccctta cggatacatc attagcagtg 102000
atgtgtggct accaatttca ccagttttcc agttatttgg cggaagaggg gagggtcgaa 102060
ctcccaaggc gctattaacg ctcggctatt ttcaagacag atcccgtcgc cagctatcgg 102120
gttgctcttc cattaaaata agatgatgcc tcgactacac cgggctgttc aaagccccgc 102180
caggattcga acctgttaaa acagtgtttc cgccagccgt aggtttcact gatcatcaaa 102240
tttggtgggg ctagggagac tcgaactccc acgcatttaa gctacggaat ctaaagccgt 102300
attgtctacc agttccagca tagccccatt tgtttggtgg agtcacagag attcgaactc 102360
tgctgctatc ctcggtgcaa gcgaggtgtc cactcctagc agaccctgac cccaataatt 102420
tgttaaggca attaatccgg tgagcgtaat accctgagca attagccatg caaggatacc 102480
cgctcttcac aaatacgata cactctacgc ttaccaggcg tttcggagag ccactccgct 102540
attcttgcaa agcccctctt ggggtttcta ctctgcaagc gtgttttttg gtgccgactc 102600
tgtatcagat taattcctta acaaactata taaatattat atcaatttgt taagcattta 102660
gcaactgaat ttttcagtaa atttggtact cccgacgggg ttcgaacccg tgttcccact 102720
gtgaaagagt ggtgtcctaa ccagcttaga cgacaggagc attttaaatt tggcaaggga 102780
aggaggagtt gaacctaccg atctcggagt caaaggccga tgccgtaacc acttggctat 102840
tccctttcaa tataaatatt atctcaaatt ctagagcatt tagcaattga atttttcaag 102900
tattttggta gtgacccggc aacgcaggtc actatgcaaa ctactcgccg tggtctacac 102960
gaatgagcgg acaaagtttg tccttcttat agattcgcat cttctggtag atattaccga 103020
agcggagctc ttcatcgcga gcattatact ctttctgtgc cctttcgaag gatttgctct 103080
cgttccaatc ttggatccga tcctctatct tagcgcaggc ccagccgatc ccagctatcg 103140
ccagcagaat cgctactagc gtagatagtc ctgctagact taaccctaca agcatgtacc 103200
agggagtaat tcccagctca aaggtgagac ccaagaacgt agataagata cttcccatcc 103260
ccaaggagaa gagtacagca atagcagtta cgccaatctg tagcaggaaa taccacactg 103320
agtgccaaaa taggctacac aaggtgactc tgttgtcgtt cagccggtag gtgaaagacg 103380
cggaagagaa attaagccac ttgtagaaaa aacctttacg tttaatattc agcatattta 103440
gcctattact tgagttgatt gattaggaaa acttgtagcg cgataatgaa tgcggcatag 103500
gagtcagagc ctttaccacc ttcgttctca ttaacttctt ttagtagggc ttcaaaagct 103560
gctttgtgac gctcatagtg ccctctgact gtcgggccag cagcctctaa catgcctaaa 103620
aacatatagt actgggtttg taattgagcg tccattagtc ctcccacacg attttaatcg 103680
agagaagacg atttacagga atgaccagca tagtctcaga ctgtttatta aggatttcca 103740
ggatatcccc atcacgatgg agcagacgtt taggactgat atctgttact gtggactcta 103800
ggacgatacc actgtcatcc acgaaggata cgattgcgtt tttagtagac attttagtct 103860
cctgttatga aattggtggg ccaggggaga ctctaactcc cactcgttgg cttatgaggc 103920
cactgcttta actttaagct accggcccaa ggagaagggc tatttctagc ccttagttat 103980
ttatactgct gcttcatctt ccggagtgcc ttccaccgga aggttcttca gtagtggtat 104040
ccgctaccgg agtgtcttca gttggagtat cttcagccgg ctccgggtct ttcacgaagc 104100
ctgcttcttc gtcggagatt acgtacagat cctgaatgtc ttcggtattg atcatacgag 104160
ctacgctacc gtctttatag aatacggttt tggtaccttc gttgcgggcc atatttgcat 104220
caataaccag ttccgtcaga acacctttct ttaaatattc gattttaaat gccatgttat 104280
cctctacttt ctctttgatt taaagaacta ttatacaaaa tttctgacaa aattgcaaga 104340
aaaattttgt agaattaatc tcagtctgcg ccctgcgggc ttttgcccgc tgcctacaca 104400
aaattacgtg cgggcagcga taaagtggta ctccctacag gattcgaacc tgtgacccac 104460
ggtttagaag accgttgctc tatcctctga gctaagagag cattaataaa gtttaagcgt 104520
ttttacaacc agatcgtgaa cctgttcaga ataccggcca acgctcttat gcagcgactc 104580
tttaaactct agagtacgcc tggcgattag ctgtttctgt tctggtgtca gattaggtgc 104640
tggacgttca tacggaggag tatgcacaga tgccaccatt attagacctt gatagaattt 104700
ttgagacgat cacattcagc ggcgaactga acgtttaggg ttttgattac gtccgtacac 104760
tgatctattt gtttgtctag ggctttgata agtcctagct tcaccatatc gtaacagggt 104820
ttcatctcga aagtgtaatc tcgagtcagc tccccacaca gatcaaacgt aagatctcca 104880
gcgcgtagtg taaagcgctg ttgcgtacca ccgctgatga tttgtttagc cttagtcagc 104940
tcactacgac gagagaccat agactgaata tcagagcgta tcttagttaa catacttaaa 105000
tcgttcatat agacctcgtc aattagtatc tttaagaact ctcgtaaaag ctcttaaaga 105060
taccgccagt aggtaggggc cttcccctgt ttaagctatg cggcccttct gtcagacgta 105120
tcttccagtt atagtcaagg tgactaatat aaaccccaca tagtttccac agcggggcac 105180
actccaaaca ggggcacttc tagcctgtgt aagggtgcta taaatagtgg ttatgctttc 105240
gctcggggtg actccggtca tgactccatt gtcacatgct tacacagggt atacgagctt 105300
ccgcggagct gtatactcaa ccgtgtccca cttaggtctc ggagcgaccg tttgtacgaa 105360
cggttatccg aatactcttt cccacttaga gtcaggcgag atcctacctc gccaaagttc 105420
atacgatcat cgtgccgtat ttaaggacta gctttggcac ttctggagag ccatcctcca 105480
cgcggtctgt taaaatcaca cctccgaatt ttcgatgtga agttttgata gcttgaaaaa 105540
cgactcctcg tggaggaaaa acttcactat ctaggctacc gcctaaagtt cttcttttga 105600
tttgggcata tatcaggtaa gggtagccaa atcagcatcc tagtccttcg tggtttagct 105660
gtttcgttcc cgcgagtctc ccaagtcttt tcctgggagg ggaggaggta ctccagcagc 105720
gagtggttcg ccaatagaac catcagttat ctagctcttt ccgaccgcag gacttgaacc 105780
tgcatcttcc ggcagttacg ccatgataat gcccattata ctaggacggc agtgttgcta 105840
cataagtgat ttcgacaccc cactatggtg gcaataacta gcaccagacg ctatacacat 105900
gtctccaatt tgcggcctag gcaggtcagt gtgggagcta tacgagtttc tcaggctcag 105960
ctccccacct ctccggcagg ccacgcacca tgcttcattc tggtagaaca ggttaaagtg 106020
agattccacc attttctata aatcaggaga agagtttacg agactccggg acagctcccg 106080
agttttacaa gagatctcta acctacgccc gtccaatacg ctccctggcc ggtatccgga 106140
ctggatgcac gaactttgtc aggtgatcac tcttaactca ccgattctat tcaacgaatc 106200
ttaatgctcg acgagtctta cattaaaaca agttcagcgt aatcggcccg ctgttctctc 106260
taatttatga aactattata tcaacttttt aagcattagg caactgagat tttaatttat 106320
agaacacatg gttgccaatt ttacttgttc ttttgaagtc cttgtctttt gtccagtaag 106380
gtttagtatc tttactgtga aagtacaaag ctcccttcgt cggatctact ggaagatcca 106440
tatagtaaac tagtctagct atctctttag cttgtttcca ctcttcgtct ttacgatcga 106500
gtttatgttt ctttttacca acccagctga actgccctgg ttgatagact actttacaat 106560
atgtggacgg gaattttcca tagttaacac gattttttgt tacttgtgca actgcggtca 106620
ttcctttaac tccttcccct ctagcttcaa agtacacatt tttagctatg cactctatct 106680
catgcgcatc aatctttgcc tgcgcatgga agctagtgag gatggagatc attagaatgg 106740
ctgctttcat tatttctcct ttactctttg attcaagaat aatagtatat caagaaatca 106800
gccatttagt caaatcaaat tttcaatttc gattcgatag ttttaataca gtacgcttct 106860
accagggcgt caaacaccgg atcatgtttc gacggataga ccccctcagg aatcaggttg 106920
taacgctcga ttacgtcgtg tgcgtagatt tcagcacaac gtaccaatgc tttccagtct 106980
cctccgagag cctcgaaata gtcacgcggg ttacgggcgc tagagatatc ccagaatttc 107040
cacggaacga ttgcaggatc agacggagag aagacgttag cctgagccgc cactgtttcg 107100
taaatagaca tatcgaactg tgggccatta ccgtagtggc gcagggaacg agtgtcgata 107160
ccttgctcat cgataattcc ttcgattacc tgttttgcct ctacgaacgg gcagatcaga 107220
tccatgaacg tatgcttgga taccggtgac tcatgagtcg ggttgcaaac cagaacagta 107280
gactctccgt ctttagcgtt cagggcttcg ataatggaca gcgacggagc actacccgca 107340
cgagcctcat tcatccagaa tgcaatagtt ccggcggaca ccttagcacc gagggccaac 107400
tgctgggcaa cgttaggggt gcctagaacg atatacgggt ctaacgatag atctttcatt 107460
agtacgaaag cgaaagacgg catagcgata aaggtgctct tgcagtctcc cggagttccc 107520
agagattcga tatcacaaac agagatccag cggtcttgta agttttgcat attgtttcct 107580
ttgttattaa agttgcttct agatgtgtta tcacatttag aagccacctc cggtggtggc 107640
ttagtcatat cttcggacac atcccagttt tcttccatag acggccagtc agccacccaa 107700
tcttcgagtt cttcgtagca cgaatccatc agttcccggg agttgaccct agagtaatcc 107760
agggccgact tatgtgtcgc tgcacgattg aaatcgtttt tagctacaaa atttcgcatt 107820
atgccttctt agcgggtttg cgtttttgat tacgaggctt atttgccttg cccgtaaatt 107880
taatacctac gccatagcac agagcgcgaa cattctcacg gctgtattcg caaccgaaga 107940
tattcggctt gacgctaccg aaacggccct gggtcttgcg caggacttct ttggtgtctg 108000
ccttatccgg cgtactccaa ccgacgatct tggagacata gccagaggta gaacccttag 108060
ttaccggctt cttacgacgc ggggccggtt tacctacagc tgatgctgct tgagtatcag 108120
ccggatgttt acgcagatga cgctccagac gtgctttgcg attcgcttca gttttgggaa 108180
aagttgcaac tttggtttct actgcttttt tagaggtctg cttagccatg atttatttcc 108240
tttgttttga ttggtttcgt taatttatga atctattata cgttactttt tagcgtttag 108300
caactgcgtt ttttcatttt catctacaag ctcatcgaag atgatgaact cgcacctgtt 108360
accgcccgat gtgcttcgct tgctcttccg agctgatgta ctggtacccg cctttgttgt 108420
acgctggggc ggtacagagt ttctttcgct caatttcttt aagagcggct cgttctcttt 108480
cagccatctc aggatccagg atttcccgtg cctgcggtct tggtggtaga cgcgtagagg 108540
gttccccgat tttgacgctt ccagaaacgc ggcgtagaga tcgagctggt actgtggtac 108600
gtttgggaac aaatccctca aatcttgatt gattatacat ggtttcacat atcctccgta 108660
tggtaagagt cggattgcgt ttctctattg aactccctaa ctctatgctt acctttaata 108720
atggaggaca aagtcgaggg ggacacgcca aattctctgg ccattgctcg tataccatgt 108780
atagggtctc tgggcttgta tctagctctg atttctgtta cttgctcaga agtaagttta 108840
gatcttccat gattttctcc taccttagat aacccgcaat caaaggcatg tatggtgttg 108900
gccgatgcag tagaccactc taagttatct ttatgtacgt gtgctttaat accgtctttg 108960
tgatttacct caggtaaacc cagggggtta ggtataaaag cctttgctac acatacatgt 109020
actcttagat tgtgcttctt gttattagca gatatacagg tataaatata ccctcctacc 109080
ccttcttgct tatgcaagat tttgtttctt ttgatggatt tgatatctcc actttcattt 109140
ataatgtagt gatcctcgaa tccgggtaga ggtacccaat tacatgtctt caagtattgc 109200
ctcctccatg cgaacattta gcaggttatc tgcagcctca ttaccttcta caccggagtg 109260
acccttaacc ttaacgaaag ttgggatctc attgtggttt agacgatact tcttgagttc 109320
gtcgataatc cacttccact ggtctaagtt cagaggtgta tcaccgtctg ccttcttcca 109380
gcctttacgt tcccaacccc aaacccagga ctcacaacca ttcttaacgt aggttgagtc 109440
caaatagatt gtcattggtc ggccagggtt tttgttagac catagcagag cctctaggac 109500
tgcttgaagc tccatctcgt tgttagttgt gttgcgtttg ggagcagact tggtgccgat 109560
ttgctcttcg ctggagttgt aaactaccat agcccaagca ccaacattgt ctacgccacg 109620
agtattaccg cggcaaccgc catcagtata aacatgaaac attatgcgtg cccccaggaa 109680
atggtaattg attcagtatc acgttggtca aacggatgat ttacttttac ttcatagccc 109740
gcgtccttta ggtcttccat aatctgagac cgtgcggaga taggcagacc attcaatgcg 109800
taagaatcta cttttgtttt acctgaagaa gctgacccat caatatttga tataatagat 109860
ctgcgagctg ctataactgc catatcgtta gaccttttgg ctttagctgc cattgctttt 109920
gcatcagtaa aagacatatt tatttcctct ctcaaattta tgaatctatt atattagaaa 109980
ttcacgtggt ttgcaaatga atttttaata taagtggccc gaaggccacc ttagttatag 110040
taatttagct ggaggaacta gtaaattact gttatagccc agcttggctg gagggttttc 110100
ttttggcggt ttaggggcaa actgacgcat tagtgcgtcc atgcccttgt actttaccat 110160
ccctaggata acgtctatgt gtaatcctga agattgaacc agaaacttca gctgagactc 110220
ctccctttcg gagaaggtta ttttagggcg tctgttaaat aatcccataa gtcctcacgc 110280
ggtgaacgga tacgcaatag ggtcatgaga cttatacccc acgattttaa agtcgtcctt 110340
agaaacccag gtgagtacgt cctctagggt ttttatttcc gggttgatct ctagacgagg 110400
ggccgggaaa ggtttgcggt cgaattgccc atgttccatg agaaccttgt actgattctc 110460
gtagatgtgc atatttacta tacgctggtt tgctctgatt gcccggttcc ctgtgatctg 110520
ggccataagc gcaagaaacg tgtagcattg gaccatgtta aaggcttgtc ccaataggaa 110580
gtcattggat ctctggaagg agtcgagata cagatttcca ttgagtagcg agaactggtg 110640
ggtatgcatg cacggtcgta agcatccttg atcaaattcg ccagggttcc agaaggtgag 110700
aatctctccg cggtcatcaa tgcctcgtcg taaattctca tagatcttat agagttggtc 110760
aaagtgggaa ccatccggtc gaagccacgt tctgccctgt actccataga ctctacccat 110820
atcgtcggtt ccctttctgt tagggttgac cagccacgcc tcgttttcgt tggcgttagc 110880
gttccacgta ttgcagccga tagcacggaa ttgctctgcg gaatcatatc ctcgcagata 110940
tccgataagc tccatgatgg cctgaagagc atacgcttta cgagttgtga taagtgggaa 111000
tttctttccg agtacatcat attcaaagtt tgaccctatt acggttaaac aacgaacccc 111060
cgttcgaggg ttctccagcc agacaccctc ttcgagaatg cgtttgcctt cattaatata 111120
gtgaatcaca gatagactcc ttccataaca aaacgatagc gctcattttc cccagaagct 111180
acatgagtta ctacagcatc cggaggagtg gacgtaagta tcgggtgctc cagatacata 111240
atgtggtcta ggcttggtac tgtacccgcc ctaggataaa tggtggagcg ataaatcgca 111300
tccagacagc ccatagttgc tagagtttct agcagagctt tcccgccgat gcagactacc 111360
tctacttcat tacagaagtc ccggattttg gaacccaagt gggtaataaa ccgcacgtta 111420
cggggaggat tttttatcag aaccggagcc ttagaaccta ctacgtacac catggatttc 111480
ttttccagtg cttttttcag tcggggaggt gccgttgtgt aggtattatg tcccaggata 111540
acaacctgat aggtatccag gattttgtag aactgttcta gttcctcggg gatggagccc 111600
cagggaagtt ccccgtaggc atccatcgta gccggattaa aaatcccgaa ggctccatca 111660
actcgcattg cgtataaagc tgtaatcatt acaggaactc tccaaattcg tcagacagat 111720
cgtccgggtt agcctgagag gttgcaccaa cacgatagtt ggtaatctgt gcttcttgcg 111780
gagctacttg ctggttcttg gtgttcagcc aacctttcat ccagccaata ggatcttcca 111840
taattaccgg gagatcttcc ggccacggaa tgttgattgc cataaatgct aggcgtgcgt 111900
tgtaatacag gtactctacc agcaaatcgg cgttcagacc aggaatatct tcgccttccg 111960
ggaaaatata atgcgcccaa ttaatttctg tctccagaat actgcgcagg atcttcggag 112020
cattagcctg agctgctgct acaacatggg gaggaaattc tccactctgg ataatacgca 112080
gaacttccat cgccataacg gtgtggagcg cttcgtcttt tgcgataagc tgtaggttct 112140
tagcgatacc tgtcagaata tcgttctccg ccagagcaaa ggtacatgca aatgaagcaa 112200
aaaacataat ggcttctaga gcgtatacag cgtagtagaa ctccagaatc ttctgctgta 112260
cttgttcagt aagtgctaag aagtctgcct cttcggtgta ttccagagta ccttccttct 112320
cagcgatttc cagattggct ctagcgtc 112348
Claims (10)
1. The high-lytic Klebsiella pneumoniae phage is characterized in that the phage is Klebsiella pneumoniae phage (Klebsiella pneumoniae phase) RDP-KP-20007, and the preservation number is CGMCC No. 22495.
2. The Klebsiella pneumoniae phage of claim 1, wherein the Klebsiella pneumoniae (Klebsiella pneumoniae phase) RDP-KP-20007 head is icosahedral and has a three-dimensional symmetry, the head is 72.640nm, the tail of the phage is 177.797nm, and the phage belongs to the family Chinophagidae of the order Chinophagales.
3. The Klebsiella pneumoniae phage of claim 1, wherein the Klebsiella pneumoniae (Klebsiella pneumoniae phase) RDP-KP-20007 has an optimum temperature of 37 ℃ and a titer of up to 10^11 pfu/mL.
4. The Klebsiella pneumoniae bacteriophage according to claim 1, wherein the Klebsiella pneumoniae (Klebsiella pneumoniae phase) RDP-KP-20007 has a strong lytic effect on Klebsiella pneumoniae in an avian breeding environment.
5. Use of the klebsiella pneumoniae RDP-KP-20007 according to any one of claims 1 to 4 in the preparation of a medicament for the prevention and or treatment of a disease caused by klebsiella pneumoniae.
6. Use of the klebsiella pneumoniae RDP-KP-20007 according to any one of claims 1 to 4 in the preparation of a feed for preventing and or treating diseases caused by klebsiella pneumoniae.
7. A fungicidal composition for controlling Klebsiella pneumoniae comprising an effective amount of Klebsiella pneumoniae (Klebsiella pneumoniae phase) RDP-KP-20007 according to claim 1.
8. Use of a Klebsiella pneumoniae phage according to any one of claims 1 to 4, wherein Klebsiella pneumoniae (Klebsiella pneumoniae phase) RDP-KP-20007 is used as a potential therapeutic drug or health product for bacterial infection caused by Klebsiella pneumoniae.
9. An additive for preventing and/or treating diseases caused by Klebsiella pneumoniae, wherein the effective component of the additive comprises Klebsiella pneumoniae (Klebsiella pneumoniae phase) RDP-KP-20007 according to claim 1.
10. A cleaning or disinfecting agent for an avian farming environment, comprising Klebsiella pneumoniae (Klebsiella pneumoniae phase) RDP-KP-20007 according to claim 1.
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Denomination of invention: A highly lytic Klebsiella pneumoniae phage RDP-KP-20007 and its application Effective date of registration: 20230628 Granted publication date: 20220802 Pledgee: Weihai commercial bank Limited by Share Ltd. Qingdao branch Pledgor: Rec Union (Qingdao) Bioengineering Co.,Ltd. Registration number: Y2023980046462 |