KR101863593B1 - Novel Salmonella specific bacteriophage SP1 and antibacterial composition comprising the same - Google Patents

Novel Salmonella specific bacteriophage SP1 and antibacterial composition comprising the same Download PDF

Info

Publication number
KR101863593B1
KR101863593B1 KR1020160176983A KR20160176983A KR101863593B1 KR 101863593 B1 KR101863593 B1 KR 101863593B1 KR 1020160176983 A KR1020160176983 A KR 1020160176983A KR 20160176983 A KR20160176983 A KR 20160176983A KR 101863593 B1 KR101863593 B1 KR 101863593B1
Authority
KR
South Korea
Prior art keywords
bacteriophage
salmonella
present
composition
feed
Prior art date
Application number
KR1020160176983A
Other languages
Korean (ko)
Inventor
김영주
연영은
김선진
한범구
김현일
박철세
Original Assignee
주식회사 옵티팜
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 옵티팜 filed Critical 주식회사 옵티팜
Priority to KR1020160176983A priority Critical patent/KR101863593B1/en
Application granted granted Critical
Publication of KR101863593B1 publication Critical patent/KR101863593B1/en

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/195—Antibiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/3571—Microorganisms; Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/381—Microorganisms
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00031—Uses of virus other than therapeutic or vaccine, e.g. disinfectant
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Husbandry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Mycology (AREA)
  • Physiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)

Abstract

The present invention relates to: a novel bacteriophage SP1 having a specific killing ability to salmonella and, specifically, salmonella pullorum; an antibiosis composition, a feed additive composition, a feed, a disinfectant or a cleaning agent, and a pharmacological composition for prevention or treatment of an infectious disease due to the salmonella, including the bacteriophage; and a prevention method or a treatment method of an infectious disease due to the salmonella, including a step of injecting the bacteriophage into a subject. According to the present invention, the preventive method or treatment method of the infectious disease due to the salmonella using the bacteriophage SP1 provides very high specificity about salmonella in comparison with a chemical matter such as an existing antibiotic, and the bacteriophage SP1 has excellent bacteriolytic activity since the bacteriophage SP1 is increased in bacteria infected by the salmonella. Also, the bacteriophage SP1 is resistant to physiochemical stimulation. Moreover, according to the present invention, the bacteriophage SP1 does not infect other hosts except germs, such as a person, other animals, or plants and can solve a problem of a wide host range, and a remaining problem of the antibiotic in food, and a problem of bacteria resistant to the antibiotic due to abuse of the antibiotic. Therefore, according to the present invention, the bacteriophage SP1 can be variously used in fields of antibiosis composition, feed additive composition, feed, disinfectant or cleaning agent, and a composition for the prevention or treatment of infectious disease due to the salmonella, specifically, salmonella pullorum.

Description

신규한 살모넬라균 특이 박테리오파지 SP1 및 이를 포함하는 항균 조성물{Novel Salmonella specific bacteriophage SP1 and antibacterial composition comprising the same}A novel Salmonella-specific bacteriophage SP1 and an antimicrobial composition containing the Salmonella specific bacteriophage SP1 and an antibacterial composition comprising the same,

본 발명은 살모넬라균, 특히 살모넬라 플로럼(Salmonella Pullorum)에 특이적인 사멸능을 갖는 신규 박테리오파지 SP1, 상기 박테리오파지를 포함하는 살모넬라균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 및 상기 박테리오파지를 개체에 투여하는 단계를 포함하는 살모넬라균에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다. The present invention relates to a novel bacteriophage SP1 having saliva-specific ability to Salmonella , particularly Salmonella Pullorum, a pharmaceutical composition for preventing or treating infectious diseases caused by salmonella including the bacteriophage, an antibiotic composition, A feed, a disinfectant or a cleansing agent, and a method for preventing or treating an infectious disease caused by Salmonella comprising the step of administering the bacteriophage to a subject.

살모넬라 (Salmonella)는 장내세균과에 속하는 그람음성의 통성 혐기성 세균으로, 아포를 형성하지 않는 간균이다. 살모넬라균은 사람 뿐만 아니라 돼지, 소, 닭 등을 비롯한 다양한 가축에 감염되어 질병을 유발하는데, 사람에게 감염되어 식중독을 유발하고 동물에게 있어서는 다양한 살모넬라증 (Salmonellosis)을 유발하는 병원성 미생물이다. 살모넬라 엔테리카 (Salmonella enterica)는 혈청학적 구분에 의해 장티푸스를 일으키는 살모넬라 타이피 (Salmonella Typhi), 쥐티푸스의 원인균인 살모넬라 티피뮤리움 (Salmonella Typhimurium), 장염균인 살모넬라 엔테리티디스 (Salmonella Enteriditis), 가금티푸스의 원인균인 살모넬라 갈리나룸 (Salmonella Gallinarum), 추백리 원인균인 살모넬라 플로럼(Salmonella Pullorum) 등의 혈청종을 포함한다. 살모넬라균은 혈청형에 따라 인간뿐만 아니라 가축에게도 질병을 일으킬 수 있는 인수공통 감염원을 포함한다. 살모넬라 티피뮤리움과 살모넬라 엔테리티디스는 인수공통 감염원으로 사람에게 있어서는 식중독의 원인이 되며, 소, 닭, 돼지 등의 가축에 있어서는 살모넬라증 (salmonellosis)을 일으켜 급성 또는 만성 장염과 패혈증, 더 나아가 폐렴, 관절염, 유산 등을 발생시킨다. 살모넬라 갈리나룸과 살모넬라 플로럼은 가금 특이적 감염균으로 가금티푸스와 추백리를 일으켜 가금류의 대량 폐사를 유발할 수 있다. 살모넬라 플로럼은 성계에서는 감염되어도 임상 증상이 없으나 부화된 후대 병아리에게 난계대 전염되어 추백리를 일으키며, 생후 1-2주령에서 가장 높은 폐사율이 나타난다. 주로 회백색의 설사 증세를 보이면서 항문을 막아 배분 곤란을 일으켜 복부가 팽창하고, 그로 인한 패혈증으로 폐사한다. 추백리와 같은 경우 상업화된 예방책이 없으며, 감염된 개체의 색출 및 도태를 통해서만 질병의 예방이 가능하다. Salmonella (Salmonella) is a facultative anaerobic bacteria belonging to gram-negative enteric bacteria and a bacillus which does not form a spore. Salmonella is a pathogenic microorganism that infects humans as well as humans, including pigs, cows, and chickens, causing disease, causing food poisoning in humans, and causing various forms of salmonellosis in animals. Salmonella Entebbe Rica (Salmonella enterica) is serologically by the segment that causes typhoid Salmonella tie blood (Salmonella Typhi), Salmonella typhimurium (Salmonella Typhimurium) the cause of rat typhus, jangyeomgyun of Salmonella Entebbe utility disk (Salmonella Enteriditis), poultry include serum, such as species of Salmonella cause of typhus Galina room (Salmonella Gallinarum), the causative agents chubaekri Salmonella flow column (Salmonella Pullorum). Salmonella contains common infectious agents that can cause disease not only in humans but also in livestock, depending on the serotype. Salmonella typhimurium and Salmonella enteritoridis are common infectious diseases and cause food poisoning in humans. In animals such as cattle, chickens and pigs, salmonellosis is caused by acute or chronic enteritis, sepsis, and even pneumonia, Arthritis, and lactic acid. Salmonella Galina room and Salmonella florum are poultry-specific infectious agents that cause poultry typhus and mullet to cause massive deaths of poultry. Salmonella fl rum has no clinical symptoms even when infected in the sex system, but it is transmitted to the hatching chick after hatching, causing the mulberry tree and the highest mortality at 1-2 weeks of age. Mainly grayish white diarrhea with symptoms of obstructing the anus to cause difficulty to expand the abdomen, resulting in sepsis due to death. There are no commercialized preventive measures such as shingae, and disease can be prevented only through detection and culling of infected individuals.

현재 살모넬라 감염증을 예방 및 치료하기 위해 항생제를 주로 사용하고 있으나 살모넬라는 동물에 감염 시 세포내에 침투하여 증식하고 감염하는 경우가 많아 항생제나 약제, 기타 생균제가 침투하여 작용하기는 어려우며, 최근 많은 분야에서 항생제 내성에 대한 문제가 발생되고 있어 이에 대한 원인을 항생제 오남용으로 규명하고 항생제를 충분히 사용하지 못하게 되었다. 이에 따라 산업동물의 배합 사료 내에 성장촉진제로 사용하는 항생제를 금지하기 시작하였고, 유럽연합에서는 2006년부터, 우리나라에서는 2011년 하반기부터 항생제 사용을 규제하기 시작하였다. 또한 항생제가 없는 안전한 먹거리에 대한 소비자의 요구가 증대되고 있어 점차 항생제 사용이 줄어들고 있다. 세균을 제어하는 항생제의 사용이 줄어듦에 따라 세균성 질병의 발생이 증가하고 있어 항생제를 사용하지 않고 세균성 질병을 제어하는 방법에 대한 요구가 늘어나고 있다. 이러한 연구 중 하나가 자연계에 존재하는 세균을 특이적이고 효과적으로 사멸하는 박테리오파지를 이용하는 방법이다. Currently, antibiotics are mainly used for the prevention and treatment of Salmonella infectious diseases. However, Salmonella is infected and penetrates into cells when infected with an animal. Therefore, it is difficult for antibiotics, medicines and other probiotics to penetrate and act, There is a problem about antibiotic resistance, so the reason for this is due to abuse of antibiotics and the use of antibiotics is not enough. As a result, antibiotics used as growth promoters in industrial animal feeds began to be banned. In the EU, in 2006, Korea began regulating the use of antibiotics in the second half of 2011. Consumer demand for safe food without antibiotics is also increasing, and the use of antibiotics is gradually diminishing. As the use of antibiotics to control bacteria decreases, the incidence of bacterial diseases is increasing, and there is a growing demand for methods to control bacterial diseases without the use of antibiotics. One of these studies is the use of bacteriophages that specifically and effectively kill bacteria in the natural world.

박테리오파지(bacteriophage)는 특정 세균을 감염시켜 감염된 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스를 의미한다. 박테리오파지는 박테리아에 감염(infection)한 후 박테리아 세포 내부에서 증식을 하고, 증식 후 자손 박테리오파지들이 박테리아 밖으로 나올 때 숙주인 박테리아의 세포벽을 파괴하는 방식으로 박테리아를 사멸시키는 능력을 갖고 있다. 박테리오파지의 박테리아 감염 방식은 매우 특이성이 높아서 특정 박테리아에 감염할 수 있는 박테리오파지의 종류는 일부로 한정된다. 즉, 특정 박테리오파지는 특정 범주의 박테리아에만 감염할 수 있고 이로 인하여 특정 박테리오파지는 특정 박테리아만을 사멸시키며 다른 박테리아에는 영향을 주지 않는다. 따라서 최근 세균성 질환의 대처 방안으로 박테리오파지(bacteriophage)의 활용이 크게 주목을 받고 있다. 특히 2000년 이후에 항생제 내성균의 증가로 인하여 기존 항생제의 한계성이 나타나고, 기존 항생제의 대체 물질로의 개발 가능성이 부각되면서 다시 박테리오파지가 항-박테리아제로 주목을 받고 있다.Bacteriophages are bacterial-specific viruses that infect certain bacteria and inhibit and inhibit the growth of infected bacteria. Bacteriophages have the ability to kill bacteria by infecting bacteria, multiplying inside bacterial cells, and destroying the cell walls of the host bacteria when the progeny bacteriophages come out of the bacteria after proliferation. The bacteriophage infection method of bacteriophage is highly specific, so the type of bacteriophage that can infect a specific bacterium is limited to some. That is, certain bacteriophages can infect only a specific category of bacteria, which causes certain bacteriophages to kill only certain bacteria and not other bacteria. Recently, the use of bacteriophage has attracted much attention as a countermeasure against bacterial diseases. Especially, since 2000, the limit of existing antibiotics has appeared due to the increase of antibiotic resistant bacteria, and bacteriophage is attracting attention as an anti - bacterial agent again with the possibility of development as a substitute for existing antibiotics.

그러나 현재까지 양계 산업에 막대한 경제적 피해를 일으키고, 사람까지도 감염시킬 수 있는 살모넬라균에 의한 감염증을 예방 또는 치료하기 위한 신규한 박테리오파지에 대한 연구는 여전히 부족한 실정이다. 따라서 살모넬라균에 특이적인 용균활성을 갖는 박테리오파지 및 이의 응용에 대한 기술 개발이 필요하다. However, research on new bacteriophage to prevent or treat infectious diseases caused by Salmonella which can cause infectious damage to the poultry industry and infect human beings is still insufficient. Therefore, it is necessary to develop a technology for bacteriophage having a lytic activity specific to Salmonella and its application.

이에 본 발명자들은 살모넬라균에 특이적인 용균활성을 갖는 박테리오파지를 분리하고 분리된 박테리오파지의 형태적 및 유전적 특성을 분석하여 상기 박테리오파지가 살모넬라균, 특히 살모넬라 플로럼을 선택적으로 사멸시킬 수 있음을 확인함으로써 본 발명을 완성하였다.Accordingly, the present inventors isolated bacteriophage having a lytic activity specific to Salmonella and analyzed the morphological and genetic characteristics of the isolated bacteriophage to confirm that the bacteriophage can selectively kill Salmonella, especially Salmonella florum Thus completing the present invention.

본 발명의 목적은 살모넬라균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 SP1을 제공하는 것이다.An object of the present invention is to provide a bacteriophage SP1 consisting of the nucleotide sequence shown in SEQ ID NO: 1, which has a killing activity specific to Salmonella.

본 발명의 또 다른 목적은 상기 박테리오파지 SP1을 포함하는, 살모넬라균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물을 제공하는 것이다.It is still another object of the present invention to provide a pharmaceutical composition for preventing or treating infectious diseases caused by Salmonella, which comprises the bacteriophage SP1.

본 발명의 또 다른 목적은 상기 박테리오파지 SP1을 포함하는, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제를 제공하는 것이다.Yet another object of the present invention is to provide an antibiotic composition, a composition for feed addition, a feed, a disinfectant or a detergent comprising the bacteriophage SP1.

본 발명의 또 다른 목적은 상기 박테리오파지 SP1을 개체에 투여하는 단계를 포함하는, 살모넬라균에 의한 감염성 질병의 예방 또는 치료 방법을 제공하는 것이다.Yet another object of the present invention is to provide a method for preventing or treating an infectious disease caused by Salmonella, comprising the step of administering the bacteriophage SP1 to a subject.

상기 목적을 달성하기 위하여, 본 발명은 살모넬라균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 SP1을 제공한다.In order to accomplish the above object, the present invention provides a bacteriophage SP1 having the nucleotide sequence shown in SEQ ID NO: 1, which has a killing activity specific to Salmonella.

또한, 본 발명은 상기 박테리오파지 SP1을 포함하는, 살모넬라균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물을 제공한다.The present invention also provides a pharmaceutical composition for preventing or treating an infectious disease caused by Salmonella comprising the bacteriophage SP1.

또한, 본 발명은 상기 박테리오파지 SP1을 포함하는, 항생용 조성물을 제공한다.The present invention also provides an antibiotic composition comprising the bacteriophage SP1.

또한, 본 발명은 상기 박테리오파지 SP1을 포함하는, 사료 첨가용 조성물을 제공한다.Further, the present invention provides a composition for feed addition comprising the bacteriophage SP1.

또한, 본 발명은 상기 박테리오파지 SP1을 포함하는, 소독제를 제공한다.The present invention also provides a disinfectant comprising the bacteriophage SP1.

또한, 본 발명은 상기 박테리오파지 SP1을 포함하는, 세척제를 제공한다.The present invention also provides a cleaning agent comprising the bacteriophage SP1.

또한, 본 발명은 상기 박테리오파지 SP1을 개체에 투여하는 단계를 포함하는, 살모넬라균에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.The present invention also provides a method for preventing or treating an infectious disease caused by Salmonella, comprising the step of administering the bacteriophage SP1 to a subject.

본 발명의 박테리오파지 SP1을 이용한 살모넬라균에 의한 감염성 질병의 예방 또는 치료 방법은 기존의 항생제 등의 화학물질에 비해 살모넬라균에 대한 특이성이 매우 높고, 상기 박테리오파지 SP1은 살모넬라균에 감염하여 살모넬라균 내에서 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 SP1은 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 SP1은 살모넬라균, 특히 살모넬라 플로럼에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.The method for preventing or treating infectious diseases caused by Salmonella using the bacteriophage SP1 of the present invention has a high specificity to Salmonella than the conventional chemicals such as antibiotics and the bacteriophage SP1 infects Salmonella It has an advantage that it is excellent in lytic activity and strong against physicochemical stimulation by proliferation. In addition, since the bacteriophage SP1 of the present invention is not infected to any host other than a bacterium such as a human, an animal, or a plant, it can solve problems of antibiotic resistant bacteria caused by misuse of antibiotics, residual antibiotics in food, have. Accordingly, the bacteriophage SP1 of the present invention can be used variously in the fields of prevention or treatment of infectious diseases caused by Salmonella, especially Salmonella florum, compositions for antibiosis, composition for feed addition, feed, disinfectant, or detergent.

도 1은 박테리오파지 SP1의 살모넬라 플로럼에 대한 용균반 형성 활성을 확인한 결과를 나타낸 도이다.
도 2는 박테리오파지 SP1의 전체 유전자를 분석한 결과를 나타낸 도이다.
도 3은 전자 현미경을 통해 박테리오파지 SP1의 형태학적 특성을 확인한 결과를 나타낸 도이다.
도 4는 박테리오파지 SP1의 단백질 패턴을 SDS-PAGE를 통해 확인한 결과를 나타낸 도이다.
도 5는 박테리오파지 SP1의 pH 안정성을 확인한 결과를 나타낸 도이다.
도 6은 박테리오파지 SP1의 열 안정성을 확인한 결과를 나타낸 도이다.Brief Description of the Drawings Fig. 1 is a graph showing the result of confirming the dissolution activity of bacteriophage SP1 in Salmonella fl rum.
FIG. 2 is a diagram showing the result of analyzing the entire gene of bacteriophage SP1.
FIG. 3 is a diagram showing the result of confirming morphological characteristics of bacteriophage SP1 through an electron microscope.
FIG. 4 shows the result of SDS-PAGE analysis of the protein pattern of bacteriophage SP1.
5 shows the results of confirming the pH stability of bacteriophage SP1.
6 is a diagram showing the result of confirming the thermal stability of bacteriophage SP1.

이하, 본 발명에 대해 상세히 설명한다.Hereinafter, the present invention will be described in detail.

본 발명은 살모넬라균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 SP1을 제공한다.The present invention provides a bacteriophage SP1 consisting of the nucleotide sequence shown in SEQ ID NO: 1, which has a killing activity specific to Salmonella.

본 발명에서, 용어 “박테리오파지(bacteriophage)”는 특정 세균에 감염하여 당해 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스로, 단일 혹은 이중 사슬의 DNA 또는 RNA를 유전 물질로 포함하는 바이러스를 의미한다.In the present invention, the term " bacteriophage " means a bacterium-specific virus that infects a specific bacterium and inhibits and inhibits the growth of the bacterium, and includes a single or double-stranded DNA or RNA as a genetic material .

본 발명에서, 상기 살모넬라균은 살모넬라 플로럼(Salmonella Pullorum), 살모넬라 엔테리티디스(Salmonella Enteritidis) 및 살모넬라 갈리나륨(Salmonella Gallinarum)으로 구성된 군으로부터 선택된 1종 이상 일 수 있으며, 바람직하게는 살모넬라 플로럼(Salmonella Pullorum)이다. In the present invention, the Salmonella may be at least one selected from the group consisting of Salmonella Pullorum, Salmonella Enteritidis and Salmonella Gallinarum, and preferably Salmonella Florum ( Salmonella Pullorum).

본 발명의 박테리오파지 SP1은 살모넬라균, 특히 살모넬라 플로럼에 대해 용균활성이 탁월하다. 상기 박테리오파지 SP1은 180-200 nm의 크기로, 정이십면체의 머리를 가지며 수축성의 꼬리를 가지는 형태인 마이오비리데(Myoviridae)에 속하며, 단백질 패턴 분석 결과 70 kDa, 66 kDa, 48 kDa, 37 kDa, 34kDa, 23 kDa, 그리고 18 kDa 크기의 단백질을 포함하고, 전체 염기서열 분석 결과 156,585 bp의 크기를 가지며, GC 함량이 44.7%, 전체 ORFs의 수는 201개임을 확인하였다. 또한 상기 박테리오파지 SP1은 열 및 pH에 대한 안정성이 우수한 특성을 가지고 있다.The bacteriophage SP1 of the present invention is excellent in lytic activity against Salmonella, especially Salmonella florum. The bacteriophage SP1 belongs to Myoviridae, which is 180-200 nm in size and has a truncated conformational tail and has a contractile tail. As a result of protein pattern analysis, 70 kDa, 66 kDa, 48 kDa and 37 kDa , 34 kDa, 23 kDa, and 18 kDa, and the total nucleotide sequence was 156,585 bp. The GC content was 44.7% and the total number of ORFs was 201. In addition, the bacteriophage SP1 has excellent stability against heat and pH.

박테리오파지 SP1은 서열번호 1로 표시되는 염기서열을 전체 유전자의 전체 또는 일부로서 포함할 수 있다. 또한, 본 발명의 박테리오파지 SP1은 서열번호 1로 표시되는 염기서열, 및 상기 염기서열의 기능적 동등물로 이루어질 수 있다. 상기 기능적 동등물이란 염기서열의 변형, 치환의 결과, 상기 서열번호 1로 표시되는 염기서열과 적어도 70% 이상, 바람직하게는 80% 이상, 더욱 바람직하게는 90% 이상, 더더욱 바람직하게는 95% 이상의 서열 상동성을 갖는 것으로, 서열번호 1로 표시되는 염기서열과 실질적으로 동질의 생리활성을 나타내는 서열을 의미한다.Bacteriophage SP1 may contain the nucleotide sequence shown in SEQ ID NO: 1 as whole or a part of the entire gene. In addition, the bacteriophage SP1 of the present invention may be composed of the nucleotide sequence shown in SEQ ID NO: 1 and the functional equivalent of the nucleotide sequence. The functional equivalent means at least 70% or more, preferably 80% or more, more preferably 90% or more, still more preferably 95% or more of the nucleotide sequence shown in SEQ ID NO: 1 as a result of modification or substitution of the nucleotide sequence. Or more and having substantially the same physiological activity as the nucleotide sequence shown in SEQ ID NO: 1.

상기와 같은 살모넬라균 특이적 용균활성, 내산성, 내염기성 및 내열성은 본 발명의 박테리오파지 SP1을 살모넬라균에 의한 감염성 질병의 예방 및 치료용 조성물, 및 상기 박테리오파지 SP1을 유효성분으로 포함하는 다양한 제품에 적용함에 있어, 다양한 온도 및 pH 범위의 적용이 가능하게 한다.The salmonella-specific lytic activity, acid resistance, alkali basicity and heat resistance of the present invention are applicable to compositions for preventing and treating infectious diseases caused by Salmonella bacteria and various products containing the bacteriophage SP1 as an active ingredient This makes it possible to apply various temperature and pH ranges.

본 발명의 박테리오파지 SP1은 도축장 및 양계장 부근의 하수로부터 시료를 채취하여 분리한 박테리오파지로서, 본 발명자는 박테리오파지 SP1로 명명하고 2016년 9월 30일에 한국미생물보존센터 (Korean Culture Center of Microorganisms, 서울, 한국)에 기탁하여, 기탁번호 KFCC 11690P를 부여받았다.The bacteriophage SP1 of the present invention is a bacteriophage obtained by collecting a sample from sewage near a slaughterhouse and a poultry farm, and named the bacteriophage SP1. On September 30, 2016, the Korean Culture Center of Microorganisms (Seoul, Korea) and received the deposit number KFCC 11690P.

또한, 본 발명은 상기 박테리오파지 SP1을 포함하는, 살모넬라균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물을 제공한다.The present invention also provides a pharmaceutical composition for preventing or treating an infectious disease caused by Salmonella comprising the bacteriophage SP1.

본 발명에서, 상기 살모넬라균은 살모넬라 플로럼(Salmonella Pullorum), 살모넬라 엔테리티디스(Salmonella Enteritidis) 및 살모넬라 갈리나륨(Salmonella Gallinarum)으로 구성된 군으로부터 선택된 1종 이상 일 수 있으며, 바람직하게는 살모넬라 플로럼(Salmonella Pullorum)이다. In the present invention, the Salmonella may be at least one selected from the group consisting of Salmonella Pullorum, Salmonella Enteritidis and Salmonella Gallinarum, and preferably Salmonella Florum ( Salmonella Pullorum).

본 발명의 박테리오파지 SP1은 살모넬라균에 특이적인 사멸능을 가지므로, 상기 균들에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물에 사용될 수 있다. 본 발명의 박테리오파지 SP1은 살모넬라균 중에서도 살모넬라 플로럼에 더욱 특이적이므로, 본 발명은 살모넬라 플로럼 감염에 의한 감염성 질병의 예방 또는 치료에 이용될 수 있으나, 이에 제한되는 것은 아니다.The bacteriophage SP1 of the present invention has an ability to kill Salmonella sp., And thus can be used in a pharmaceutical composition for preventing or treating infectious diseases caused by the above-mentioned fungi. Since the bacteriophage SP1 of the present invention is more specific to Salmonella flum among Salmonella, the present invention can be used for prevention or treatment of infectious diseases caused by Salmonella florum infection, but the present invention is not limited thereto.

본 발명에서, 살모넬라균에 의한 감염성 질병은 유행성 또는 급성으로 발병하는 전염성 질환을 통칭하는 개념으로, 살모넬라증 외에, 식중독, 장염, 폐렴, 패혈증 추백리 및 가금티푸스 등을 포함하나, 이에 제한되는 것은 아니다.In the present invention, infectious diseases caused by Salmonella include not only salmonellosis, but also food poisoning, enteritis, pneumonia, septicemia, poultry typhus, and the like, including but not limited to infectious diseases that occur epidemically or acutely.

상기 살모넬라증은 살모넬라균 감염에 의해 발열, 두통, 설사, 구토 등을 수반하는 증상을 총칭하는 것으로, 살모넬라증은 장티푸스와 같은 증세를 나타내는 패혈증형과 식중독 증세를 나타내는 급성위장염형으로 대별되며, 장염, 식중독, 급성 균혈증 등이 포함된다.Salmonellosis is a general term referring to symptoms accompanied by fever, headache, diarrhea, and vomiting due to Salmonella infection. Salmonellosis is classified into septicemia, which is similar to typhoid fever, and acute gastroenteritis, which is a food poisoning symptom. , Acute bacteremia, and the like.

바람직하게, 상기 살모넬라 플로럼에 의한 감염성 질병은 추백리일 수 있으나, 이에 제한되는 것은 아니다.Preferably, the infectious disease caused by the Salmonella fl rum can be, but is not limited to, shrapnel.

바람직하게, 상기 살모넬라 엔테리티디스에 의한 감염성 질병은 살모넬라증, 식중독, 장염, 폐렴 또는 패혈증일 수 있으나, 이에 제한되는 것은 아니다.Preferably, the infectious disease caused by Salmonella enteritidis may be, but is not limited to, salmonellosis, food poisoning, enteritis, pneumonia or sepsis.

바람직하게, 상기 살모넬라 갈리나륨에 의한 감염성 질병은 가금티푸스일 수 있으나, 이에 제한되는 것은 아니다.Preferably, the infectious disease caused by the Salmonella gallinarum may be poultry typhus, but is not limited thereto.

본 발명의 약학적 조성물은 1 × 103 내지 1 × 1010 PFU/mL의 박테리오파지를 포함하며, 바람직하게는 1 × 106 내지 1 × 109 PFU/mL의 박테리오파지를 포함한다. 본 발명에 사용된 용어, “PFU (plaque forming unit)”는 박테리오파지가 플라크를 형성하는 것을 수치화한 단위이다.The pharmaceutical composition of the present invention contains bacteriophage of 1 × 10 3 to 1 × 10 10 PFU / mL, preferably 1 × 10 6 to 1 × 10 9 PFU / mL of bacteriophage. As used herein, the term " PFU (plaque forming unit) " is a unit that quantifies the formation of a plaque by a bacteriophage.

본 발명의 용어 “예방”이란 조성물의 투여로 질병을 억제시키거나 발병을 지연시키는 모든 행위를 의미한다.The term " prophylactic " of the present invention means any action that inhibits the disease or delay the onset of the disease by administration of the composition.

본 발명의 용어 “치료”란 조성물의 투여로 상기 질병의 증세가 호전되거나 상기 질병의 억제 또는 경감 및 이롭게 변경되는 모든 행위를 의미한다.The term " treatment " of the present invention means all the acts of improving the symptom of the disease or inhibiting or alleviating and beneficially altering the disease upon administration of the composition.

본 발명의 약학적 조성물은 약학적으로 허용 가능한 담체를 추가로 포함할 수 있다.The pharmaceutical composition of the present invention may further comprise a pharmaceutically acceptable carrier.

본 발명에서 용어, “약학적으로 허용 가능한 담체”란 생물체를 자극하지 않고 투여 화합물의 생물학적 활성 및 특성을 저해하지 않는 담체 또는 희석제를 의미한다. 액상 용액으로 제제화되는 조성물에 있어서 허용되는 약제학적 담체로는, 멸균 및 생체에 적합한 것으로서, 식염수, 멸균수, 링거액, 완충 식염수, 알부민 주사용액, 덱스트로오스 용액, 말토 덱스트린 용액, 글리세롤, 에탄올 및 이들 성분 중 1 성분 이상을 혼합하여 사용할 수 있으며, 필요에 따라 항산화제, 완충액, 정균제 등 다른 통상의 첨가제를 첨가할 수 있다. 또한 희석제, 분산제, 계면활성제, 결합제 및 윤활제를 부가적으로 첨가하여 수용액, 현탁액, 유탁액 등과 같은 주사용 제형, 환약, 캡슐, 과립 또는 정제로 제제화할 수 있다.As used herein, the term " pharmaceutically acceptable carrier " means a carrier or diluent that does not irritate the organism and does not interfere with the biological activity and properties of the administered compound. Examples of the pharmaceutical carrier which is acceptable for the composition to be formulated into a liquid solution include sterilized and sterile water, sterile water, Ringer's solution, buffered saline, albumin injection solution, dextrose solution, maltodextrin solution, glycerol, One or more of these components may be mixed and used. If necessary, other conventional additives such as an antioxidant, a buffer, and a bacteriostatic agent may be added. In addition, diluents, dispersants, surfactants, binders, and lubricants may be additionally added to formulate into injectable solutions, pills, capsules, granules or tablets such as aqueous solutions, suspensions, emulsions and the like.

본 발명의 약학적 조성물은 질환 부위에의 도포 또는 분무하는 방법으로 이용할 수 있으며, 그 밖에 비강 분무, 경구 투여 또는 비경구 투여를 통해 투여할 수도 있으며, 비경구 투여의 경우 정맥 내 투여, 복강 내 투여, 근육 내 투여, 피하 투여 또는 국부 투여를 이용하여 투여할 수도 있다.The pharmaceutical composition of the present invention can be used as a method of applying or spraying on a diseased site, or may be administered through nasal spray, oral administration or parenteral administration. In the case of parenteral administration, intravenous administration, intraperitoneal administration Administration, intramuscular, subcutaneous or local administration.

상기 비강 분무의 경우 일정량의 박테리오파지 SP1을 물에 희석하여 분무기나 분무 시스템을 통해 비강으로 흡수 되도록 할 수 있다. 상기 비강 분무를 위한 비강 분무제 또는 호흡기용 제형으로는 에어로졸제 등을 들 수 있다.In the case of the nasal spray, a certain amount of bacteriophage SP1 can be diluted in water and absorbed into the nasal cavity through a sprayer or spray system. Examples of the nasal spray agent for the nasal spray or the aerosol agent for the respiratory system are mentioned.

상기 비강 분무제 또는 호흡기용 제형은, 수분산된 농축물 또는 습윤 분말을 분산시키기 위한 추진제 및/또는 기타 첨가제를 추가로 포함할 수 있다.The nasal spray or respiratory formulation may further comprise a propellant and / or other additives for dispersing the water-dispersed concentrate or wet powder.

본 발명의 약학적 조성물의 적합한 도포, 분무 및 투여량은 제제화 방법, 투여 방식, 대상이 되는 동물 및 환자의 연령, 체중, 성, 질병 증상의 정도, 음식, 투여시간, 투여 경로, 배설 속도 및 반응 감응성과 같은 요인들에 의해 다양하며, 보통으로 숙련된 의사나 수의사는 목적하는 치료에 효과적인 투여량을 용이하게 결정 및 처방할 수 있다.The appropriate application, spray and dose of the pharmaceutical composition of the present invention may vary depending on factors such as formulation method, administration method, age, body weight, sex, disease symptom level, food, administration time, administration route, Response sensitivities, and the ordinarily skilled physician or veterinarian can readily determine and prescribe dosages effective for the desired treatment.

본 발명의 약학적 조성물을 유효성분으로 포함하는 경구 투여용 제형으로는, 예를 들어 정제, 트로키제, 로렌지, 수용성 또는 유성현탁액, 조제분말 또는 과립, 에멀젼, 하드 또는 소프트 캡슐, 시럽 또는 엘릭시르제로 제제화할 수 있다. 정제 및 캡슐 등의 제형으로 제제화하기 위해, 락토오스, 사카로오스, 솔비톨, 만니톨, 전분, 아밀로펙틴, 셀룰로오스 또는 젤라틴과 같은 결합제, 디칼슘 포스페이트와 같은 부형제, 옥수수 전분 또는 고구마 전분과 같은 붕괴제, 스테아르산 마그네슘, 스테아르산 칼슘, 스테아릴푸마르산 나트륨 또는 폴리에틸렌글리콜 왁스와 같은 윤활유를 포함할 수 있으며, 캡슐 제형의 경우 상기 언급한 물질 외에도 지방유와 같은 액체 담체를 더 함유할 수 있다.Examples of formulations for oral administration comprising the pharmaceutical composition of the present invention as an active ingredient include tablets, troches, lozenges, aqueous or oily suspensions, prepared powders or granules, emulsions, hard or soft capsules, syrups or elixirs It can be formulated into a zero. A binder such as lactose, saccharose, sorbitol, mannitol, starch, amylopectin, cellulose or gelatin, an excipient such as dicalcium phosphate, a disintegrating agent such as corn starch or sweet potato starch, a disintegrant such as magnesium stearate , Calcium stearate, sodium stearyl fumarate or polyethylene glycol wax. In the case of a capsule formulation, in addition to the above-mentioned materials, a liquid carrier such as a fatty oil may be further contained.

본 발명의 약학적 조성물을 유효성분으로 포함하는 비경구 투여용 제형으로는, 피하주사, 정맥주사 또는 근육 내 주사 등의 주사용 형태, 좌제 주입방식 또는 호흡기를 통하여 흡입이 가능하도록 하는 에어로졸제 등 스프레이용으로 제제화할 수 있다. 주사용 제형으로 제제화하기 위해서는 본 발명의 조성물을 안정제 또는 완충제와 함께 물에서 혼합하여 용액 또는 현탁액으로 제조하고, 이를 앰플 또는 바이알의 단위 투여용으로 제제화할 수 있다. 에어로졸제 등의 스프레이용으로 제형화하는 경우, 수분산된 농축물 또는 습윤 분말이 분산되도록 추진제 등이 첨가제와 함께 배합될 수 있다.Examples of the formulations for parenteral administration containing the pharmaceutical composition of the present invention as an active ingredient include injection forms such as subcutaneous injection, intravenous injection or intramuscular injection, aerosol formulations such as a suppository injection method or a respiratory apparatus It can be formulated for spraying. For formulation into injectable formulations, the compositions of the present invention may be formulated as solutions or suspensions in water with stabilizers or buffers in water, and formulated for unitary administration of ampoules or vials. When formulated for spraying, such as an aerosol formulation, a propellant or the like may be formulated with the additive such that the water-dispersed concentrate or wet powder is dispersed.

또한, 본 발명은 상기 박테리오파지 SP1을 포함하는, 항생용 조성물을 제공한다. The present invention also provides an antibiotic composition comprising the bacteriophage SP1.

본 발명에서, 용어 “항생용 조성물”은 약제 형태로 개체에 제공되어 균을 사멸시킬 수 있는 제제를 의미하며, 방부제, 살균제, 항생제 및 항균제를 총칭하는 것이다. In the present invention, the term " antibiotic composition " means a preparation which can be given to an individual in the form of a drug to kill the bacterium, and collectively refers to preservatives, bactericides, antibiotics and antibacterial agents.

본 발명의 박테리오파지 SP1은 기존 항생제에 비하여 살모넬라균에 대한 특이성이 매우 높으므로, 유익균은 죽이지 않고, 특정 병원균만 사멸시킬 수 있고, 약물 내성 내지 저항성을 유도하지 않아, 기존의 항생물질에 비하여 제품수명(life cycling)이 긴 신규 항생제로서 이용될 수 있다.The bacteriophage SP1 of the present invention has a higher specificity for Salmonella than the existing antibiotics. Therefore, it does not kill beneficial bacteria, can kill only specific pathogens, does not induce drug resistance or resistance, (life cycling) can be used as a new antibiotic.

또한, 본 발명은 상기 박테리오파지 SP1을 포함하는, 사료 첨가용 조성물을 제공한다.Further, the present invention provides a composition for feed addition comprising the bacteriophage SP1.

축산, 수산업에서 사용되는 사료 첨가용 항생제는 질병의 예방 목적으로 사용되고 있는데, 예방 목적의 항생제 투여는 내성균 발생 가능성을 높이고 가축에 잔류하는 항생제가 사람에게 전달될 수 있어서 문제이다. 항생제가 육류를 통해 인체에 흡수되면 항생제 내성을 유발해 질병의 확산을 부를 수도 있다. 또한, 사료에 섞어 먹이는 항생제의 종류가 많고 이는 다제 내성균 발생 확률이 높아지는 문제점이 있기 때문에 좀 더 자연 친화적이면서도 기존의 항생제의 사용에서 발생한 문제를 해결할 새로운 사료 첨가용 항생물질로서 본 발명의 상기 박테리오파지 SP1을 이용할 수 있다.Antibiotics for feed additive used in animal husbandry and fisheries are used for the prevention of diseases. The administration of antibiotics for prevention is problematic because it increases the possibility of producing resistant bacteria and antibiotics remaining in the livestock can be delivered to humans. If antibiotics are absorbed into the body through meat, they may cause antibiotic resistance and spread the disease. In addition, since there are many types of antibiotics to be mixed with feed, there is a problem that the probability of occurrence of multidrug-resistant bacteria increases. Therefore, antibiotics for new feed addition, which is more environmentally friendly and solves the problem caused by the use of existing antibiotics, Can be used.

또한, 본 발명은 상기 사료 첨가용 조성물을 포함하는 사료를 제공할 수 있으며, 본 발명의 사료는 박테리오파지를 사료 첨가제 형태로 따로 제조하여 사료에 혼합시키거나, 사료 제조 시 직접 첨가시켜 제조할 수 있다. 본 발명의 사료 내 박테리오파지는 액상 또는 건조상태일 수 있으며, 바람직하게는 건조된 분말형태이다. 건조방법은 통풍건조, 자연건조, 분무건조 및 동결건조가 가능하지만, 이에 제한되는 것은 아니다. 본 발명의 박테리오파지는 분말형태로 사료 중량의 0.05 내지 10 중량%, 바람직하게는 0.1 내지 2 중량%의 성분비로 혼합될 수 있다. 또한, 상기 사료는 본 발명의 박테리오파지 외에 사료의 보존성을 높일 수 있는 통상의 첨가제들을 추가로 포함할 수 있다.In addition, the present invention can provide a feed comprising the feed composition, and the feed of the present invention can be prepared by separately preparing bacteriophage as a feed additive and mixing the feed into the feed, . The bacteriophage in the feed of the present invention may be in a liquid or dry state, preferably in the form of a dried powder. Drying methods include, but are not limited to, air drying, natural drying, spray drying and freeze drying. The bacteriophage of the present invention may be mixed in powder form in a composition ratio of 0.05 to 10% by weight, preferably 0.1 to 2% by weight of the feed weight. In addition to the bacteriophages of the present invention, the feed may further include conventional additives that can enhance the preservability of the feed.

본 발명의 사료 첨가용 조성물에는 비병원성의 다른 미생물이 추가로 첨가될 수 있다. 첨가될 수 있는 미생물로는 단백질 분해 효소, 지질 분해 효소 및 당 전환 효소를 생산할 수 있는 바실러스 서브틸리스(Bacillus subtilis)와 같은 고초균, 소의 위와 같은 혐기적 조건에서 생리적 활성 및 유기물 분해능이 있는 락토바실러스 균주(Lactobacillus sp.), 가축의 체중을 증가시키며 우유의 산유량을 늘리고 사료의 소화 흡수율을 높이는 효과를 보여주는 아스퍼질러스 오리자에(Aspergillus oryzae)와 같은 사상균 및 사카로미세스 세레비지에(Saccharomyces cerevisiae)와 같은 효모로 구성된 군으로부터 선택될 수 있다.In the composition for feed addition of the present invention, microorganisms other than non-pathogenic microorganisms may be further added. Examples of microorganisms that can be added include lactobacilli such as Bacillus subtilis capable of producing proteolytic enzymes, lipolytic enzymes and glycosyltransferases, lactobacilli having physiological activity and organic resolution at anaerobic conditions such as bovine, ( Lactobacillus sp.), Filamentous fungi such as Aspergillus oryzae , which increase the body weight of livestock and increase the milk yield of milk and increase digestion rate of feed, and Saccharomyces cerevisiae ). ≪ / RTI >

본 발명의 박테리오파지 SP1을 포함하는 사료에는 식물성으로는 곡물류, 근과류, 식품가공 부산물류, 조류, 섬유질류, 제약 부산물류, 유지류, 전분류, 박류, 곡물부산물류 등이 있으며, 동물성으로는 단백질류, 무기물류, 유지류, 광물성류, 단세포 단백질, 동물성 플랑크톤류, 남은 음식물 등이 있으며 이에 제한되는 것은 아니다.Examples of the feedstuffs containing bacteriophage SP1 of the present invention include cereals, muscle roots, food processing buses, algae, fibers, pharmaceutical buses, oils, fats, But are not limited to, proteins, mineralogy, oils, mineralogy, unicellular proteins, zooplankton, and remnants.

본 발명의 사료 첨가용 조성물에는 품질 저하를 방지하기 위하여 첨가하는 결착제, 유화제, 보존제 등이 포함될 수 있고, 효용 증대를 위하여 사료에 첨가하는 아미노산제, 비타민제, 효소제, 생균제, 향미제, 비단백태질소화합물, 규산염제, 완충제, 착색제, 추출제, 올리고당 등이 포함될 수 있으며, 그 외에도 사료 혼합제 등을 추가로 포함할 수 있다.The composition for feed addition of the present invention may contain a binder, an emulsifying agent, a preservative, etc. added to prevent deterioration of quality. An amino acid, a vitamin, an enzyme, a probiotic, a flavoring agent, A nitrogen compound, a silicate, a buffer, a coloring agent, an extracting agent, an oligosaccharide, etc., and may further include a feed mixture.

또한, 본 발명은 박테리오파지 SP1을 포함하는, 음용수 첨가제를 제공한다.The present invention also provides a drinking water additive comprising bacteriophage SP1.

본 발명의 음용수 첨가제는 상기 박테리오파지 SP1 또는 이를 포함하는 조성물을 음용수 첨가제 형태로 따로 제조하여 사료 또는 음용수에 혼합하는 방식으로 사용되거나, 음용수 제조 시 직접 첨가하는 방식으로 사용할 수 있다. 상기와 같이 음용수에 혼합하여 공급함으로써 지속적으로 살모넬라균의 숫자를 감소시킬 수 있는 효과가 있다.The additive for drinking water of the present invention can be used either in a form in which the bacteriophage SP1 or a composition containing the same is separately prepared in the form of a drinkable water additive, mixed with feed or drinking water, or directly added in the production of drinking water. As a result, the number of salmonella bacteria can be continuously reduced by mixing and supplying the drinking water.

본 발명에서 음용수는 특별히 제한되지 아니하며, 당해 기술 분야에서 통상적으로 사용되는 음용수를 사용할 수 있다.In the present invention, the drinking water is not particularly limited, and drinking water commonly used in the art can be used.

또한, 본 발명은 상기 박테리오파지 SP1을 포함하는, 소독제를 제공한다.The present invention also provides a disinfectant comprising the bacteriophage SP1.

살모넬라균, 예컨대 살모넬라 플로럼, 살모넬라 엔테리티디스 및 살모넬라 갈리나륨에 특이적 사멸능을 갖는 본 발명의 박테리오파지 SP1을 포함하는 소독제는 병원감염을 막기 위한 병원 및 보건용의 소독제로 유용하게 사용될 수 있고 일반 생활 소독제, 식품 및 조리 장소 및 설비의 소독제, 양계장, 축사 등의 건물, 축체, 음수, 깔짚, 난좌, 운반차량, 식기 등의 각종 생육 용품의 소독 등에 사용될 수 있다.Disinfectants containing the bacteriophage SP1 of the present invention having a specific killing ability against Salmonella such as Salmonella florum, Salmonella entericididis and Salmonella gallinarium can be usefully used as a disinfectant for hospital and public health to prevent hospital infection Disinfection of general living disinfectants, disinfectants for food and cooking places and facilities, buildings such as poultry houses, housing, and disinfection of various kinds of growing equipment such as bottles, water bottles, litter, stairs, transportation vehicles and tableware.

또한, 본 발명은 상기 박테리오파지 SP1을 포함하는, 세척제를 제공한다.The present invention also provides a cleaning agent comprising the bacteriophage SP1.

본 발명의 박테리오파지 SP1은 살모넬라균, 예컨대 살모넬라 플로럼, 살모넬라 엔테리티디스 및 살모넬라 갈리나륨에 특이적 사멸능을 가지므로, 상기 살모넬라균에 노출되었거나 노출될 가능성이 있는 가축의 피부 표면 또는 신체 각 부위 등을 세척하는 용도로도 사용될 수 있다.The bacteriophage SP1 of the present invention has a specific killing power against Salmonella, such as Salmonella florum, Salmonella enteritidis and Salmonella gallinarium, so that the skin surface or body parts And the like.

또한, 본 발명은 상기 박테리오파지 SP1을 개체에 투여하는 단계를 포함하는, 살모넬라균에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.The present invention also provides a method for preventing or treating an infectious disease caused by Salmonella, comprising the step of administering the bacteriophage SP1 to a subject.

상기 살모넬라균은 살모넬라 플로럼(Salmonella Pullorum), 살모넬라 엔테리티디스(Salmonella Enteritidis) 및 살모넬라 갈리나륨(Salmonella Gallinarum)으로 구성된 군으로부터 선택된 1종 이상 일 수 있으며, 바람직하게는 살모넬라 플로럼(Salmonella Pullorum)이다. The Salmonella may be at least one selected from the group consisting of Salmonella Pullorum, Salmonella Enteritidis and Salmonella Gallinarum, preferably Salmonella Pullorum, to be.

본 발명의 방법은 살모넬라균에 의한 감염성 질병, 예컨대 유행성 또는 급성으로 발병하는 전염성 질환으로, 살모넬라증 외에 식중독, 장염, 폐렴, 패혈증 추백리 및 가금티푸스가 발생한 개체 또는 발생 위험이 있는 개체에 박테리오파지 SP1을 투여하는 단계를 포함한다. The method of the present invention can be used to treat infectious diseases caused by Salmonella, for example, epidemic or acute infectious diseases. In addition to salmonellosis, bacteriophage SP1 is administered to individuals suffering from food poisoning, enteritis, pneumonia, septic shingae and poultry typhus, .

본 발명에서, 용어 "개체"는 살모넬라균에 의한 감염성 질병이 발병될 수 있는 모든 개체를 의미하는 것으로 인간을 포함한 포유동물, 가축류 또는 가금류를 포함하나, 이에 제한되는 것은 아니다. 예를 들어, 본 발명의 박테리오파지 SP1은 추백리의 원인인 살모넬라 플로럼에 특이적 사멸능을 가지는바, 바람직하게는 가금류에 투여될 수 있다. In the present invention, the term "individual " means any individual to which an infectious disease caused by Salmonella can be developed, including, but not limited to, mammals including humans, livestock or poultry. For example, the bacteriophage SP1 of the present invention has a specific killing capacity for Salmonella flumrum, which is the cause of mulberry root, and can be preferably administered to poultry.

상기 용어 "가축류"는 인간에 의하여 순화, 개량되어 사람과 함께 공동생활을 하는 유용한 동물을 지칭하는 개념으로, 예를 들어, 돼지, 소, 닭, 말, 오리 또는 개 등을 포함하나, 이에 제한되는 것은 아니다.The term " livestock animal "is intended to refer to useful animals that are refined and improved by humans to co-live with humans, including, for example, pigs, cows, chickens, horses, ducks or dogs, It is not.

상기 용어 "가금류"는, 가축 중 조류에 속하는 동물을 총칭하여 이르는 개념으로, 예를 들어, 닭, 오리, 꿩, 메추리, 타조, 거위 또는 칠면조 등을 포함하나, 이에 제한되는 것은 아니다.The term "poultry" includes, but is not limited to, chicken, duck, pheasant, queen, ostrich, goose or turkey.

본 발명의 방법에서 상기 박테리오파지 SP1 또는 조성물은 약학적 제제의 형태로 개체에 투여되거나, 가축의 사료 또는 음용수에 혼합하여 이를 섭식시키는 방법을 통해 투여될 수 있다.In the method of the present invention, the bacteriophage SP1 or composition may be administered to a subject in the form of a pharmaceutical preparation, or mixed with feed or drinking water of a livestock and fed to the subject.

본 발명의 방법에서 상기 박테리오파지 SP1 또는 조성물의 투여 경로는 목적 조직에 도달할 수 있는 한 경구 또는 비경구의 다양한 경로를 통하여 투여될 수 있으며, 구체적으로, 구강, 직장, 국소, 정맥 내, 복강 내, 근육 내, 동맥 내, 경피, 비측 내, 흡입 등을 통해 통상적인 방식으로 투여될 수 있다.In the method of the present invention, the administration route of the bacteriophage SP1 or the composition can be administered through various routes of oral or parenteral administration as long as it can reach the target tissues. Specifically, oral administration, rectal administration, topical administration, intravenous, Intravenous, intramuscular, intraarterial, transdermal, intranasal, inhalation, and the like.

본 발명의 방법에 투여되는 상기 박테리오파지 SP1의 적합한 총 1일 사용량은 올바른 의학적 판단범위 내에서 처치의에 의해 결정될 수 있다는 것은 당업자에게 자명한 일이다. 특정 개체에 대한 구체적인 치료적 유효량은 달성하고자 하는 반응의 종류와 정도, 환자의 연령, 체중, 일반 건강 상태, 성별 및 식이, 투여시간, 투여 경로 및 조성물의 분비율, 치료기간, 구체적 조성물과 함께 사용되거나 동시 사용되는 약물을 비롯한 다양한 인자와 의약 분야에 잘 알려진 유사 인자에 따라 다르게 적용하는 것이 바람직하다.It is obvious to those skilled in the art that the appropriate total daily dose of the bacteriophage SP1 administered to the method of the present invention can be determined by treatment within the scope of sound medical judgment. The specific therapeutically effective amount for a particular individual will depend upon the type and extent of the response to be achieved, the age, weight, general health, sex and diet of the patient, the time of administration, the route of administration and the fraction of the route of administration, It is preferable to apply differently depending on various factors including drugs used or co-used and similar factors well known in the medical field.

본 명세서에서 달리 정의되지 않은 용어들은 본 발명이 속하는 기술분야에서 통상적으로 사용되는 의미를 갖는 것이다.Terms not otherwise defined herein have meanings as commonly used in the art to which the present invention belongs.

이하, 본 발명을 실시예, 제제예에 의해 상세히 설명한다. 단, 하기 실시예, 제제예는 본 발명을 예시하는 것일 뿐 본 발명의 내용이 하기 실시예, 제제예에 한정되는 것은 아니다.Hereinafter, the present invention will be described in detail with reference to Examples and Preparation Examples. However, the following examples and preparative examples are merely illustrative of the present invention, and the content of the present invention is not limited to the following examples and preparative examples.

실시예Example 1:  One: 신규한New 박테리오파지의 분리 및 배양 Isolation and culture of bacteriophage

1.1 박테리오파지의 스크리닝 및 단일 박테리오파지의 분리1.1 Screening of bacteriophages and isolation of single bacteriophages

살모넬라 플로럼에 특이적인 박테리오파지를 스크리닝 및 분리하기 위해서 용균반 분석을 수행하였다. 시료는 박테리오파지가 존재할 것으로 예상되는 도축장 및 양계장 부근의 하수로부터 시료를 채취하였으며, 박테리오파지 분리에 사용된 살모넬라 플로럼은 (주)옵티팜에서 채취한 야외 시료로부터 분리 동정된 것을 사용하였다.Sputum analysis was performed to screen and isolate bacteriophages specific to Salmonella fl rum. Samples were taken from the slaughterhouse and the sewage near the poultry house where the bacteriophage was expected to be present. Salmonella flum, which was used for bacteriophage isolation, was isolated from outdoor samples collected from Opti Farm.

구체적으로, 채취한 시료를 균질화 한 후 살모넬라 플로럼과 함께 35℃에서 24시간 동안 진탕배양 하였다. 상기 배양액을 4,000 rpm으로 20분간 원심분리한 후, 상등액을 공극(pore) 크기가 0.45 μm인 필터를 이용하여 여과하여 시료 여과액을 얻었다. Specifically, the collected samples were homogenized and cultured with Salmonella flour for 24 hours at 35 ° C. The culture solution was centrifuged at 4,000 rpm for 20 minutes, and the supernatant was filtered using a filter having a pore size of 0.45 μm to obtain a sample filtrate.

전배양된 살모넬라 플로럼 150 μL를 취해서 멸균된 튜브에 넣고 3-5 mL의 LB 탑 아가(top agar) [LB 배지(트립톤 10 g/L, 효모 추출물(yeast extract) 5 g/L, NaCl 10 g/L) + 0.6% 아가)]를 첨가하여 잘 혼합한 후 미리 만들어 둔 2% LB 아가 플레이트에 중층하였다. 이를 실온에서 30분간 방치한 후 상기 시료 여과액을 각각 10 μL씩 점적하고, 다시 실온에서 30분간 방치한 후 35℃에서 24시간 동안 배양하여 박테리오파지의 유무를 확인하였다. 150 μL of the pre-cultured Salmonella platelum was placed in a sterilized tube and seeded into 3-5 mL of LB top agar (LB medium (10 g / L of tryptone, 5 g / L of yeast extract, 10 g / L) + 0.6% agar] was added and mixed well. The mixture was then layered on 2% LB agar plates previously prepared. After incubation at room temperature for 30 minutes, 10 μL of the sample filtrate was added dropwise, and the mixture was allowed to stand at room temperature for 30 minutes and then incubated at 35 ° C. for 24 hours to confirm presence or absence of bacteriophages.

박테리오파지의 존재를 확인한 시료로부터 박테리오파지를 순수 분리하기 위해서 소프트 아가 오버레이(soft agar overlay)법을 이용하였다. 박테리오파지가 존재하는 것으로 확인된 시료를 식염수로 적절히 희석하여 각 희석단의 시료 희석액 100 μL를 취하고, 대상 세균(살모넬라 플로럼) 배양액 150 μL에 혼합한 후 0.7% LB 탑 아가 3 mL을 첨가하여 잘 혼합한 뒤, 미리 만들어 둔 2% LB 아가 플레이트에 중층하여 방치한 후 35℃에서 24시간 배양하였다. 배양한 각 플레이트에서 형성된 용균반을 확인한 후, 이를 선택하여 400 μL의 SM 완충액 (NaCl 5.8 g/L; MgSO47H2O 2 g/L; 1M Tris-HCl (pH 7.5) 50 mL)에 현탁하고, 실온에서 4시간 동안 방치하였다. 상기 박테리오파지액 100 μL를 0.6% LB 탑 아가와 세균 배양액 500 μL와 혼합한 뒤 150 mm 지름의 LB 플레이트에 분주하여 중층한 후 완전히 용균이 일어날 때까지 35℃에서 배양하였다. 배양이 종료된 후, LB 플레이트에 15 mL의 SM 완충액을 가하고 실온에서 4시간 동안 천천히 교반하면서 박테리오파지 용액을 회수한 후 4,000 rpm으로 20분간 원심분리하여 상등액만 취하고 이를 0.45 μm 필터로 여과하여 최종 박테리오파지 용액을 회수하였다. 이렇게 얻어진 최종 박테리오파지의 용균반을 확인한 결과를 도 1에 나타내었다.A soft agar overlay method was used to isolate the bacteriophage from the sample which confirmed the existence of the bacteriophage. The sample which has been confirmed to be present in bacteriophage is diluted appropriately with saline, 100 μL of sample dilution of each dilution stage is taken, mixed with 150 μL of the bacterial (Salmonella fl rum) culture, and then 3 mL of 0.7% LB topa After mixing, the mixture was allowed to stand in a 2% LB agar plate which had been previously prepared, followed by incubation at 35 ° C for 24 hours. After incubation, the supernatant was added to 400 μL of SM buffer (NaCl 5.8 g / L; MgSO 4 7H 2 O 2 g / L; 1M Tris-HCl (pH 7.5) And allowed to stand at room temperature for 4 hours. 100 .mu.L of the bacteriophage solution was mixed with 500 .mu.L of a 0.6% LB top agar and bacterial culture, and then the mixture was divided into 150-mm-diameter LB plates and cultured at 35.degree. C. until complete lysis. After completion of the incubation, 15 mL of SM buffer was added to the LB plate, and the bacteriophage solution was recovered while slowly stirring at room temperature for 4 hours. Then, the supernatant was centrifuged at 4,000 rpm for 20 minutes to filter out the supernatant. The solution was recovered. FIG. 1 shows the result of checking the thus obtained final bacteria bacterium.

도 1에 나타낸 바와 같이, 2-3 mm의 크기를 가지는 용균반을 확인함으로써, 상기 박테리오파지가 살모넬라 플로럼에 특이적인 용균능을 갖는 박테리오파지임을 확인하였다.As shown in Fig. 1, the bacteriophage was found to be a bacteriophage having a solubilizing capacity specific to Salmonella florum, by confirming a frying pan having a size of 2-3 mm.

1.2 박테리오파지의 대량 배양 및 정제1.2 Bulk culture and purification of bacteriophages

상기 실시예 1.1에서 확인한 살모넬라 플로럼 특이적 박테리오파지를 대량 배양하기 위하여, 1.1에서 회수한 최종 박테리오파지 배양액을 1.0×107 PFU/mL로 희석한 후 전배양된 살모넬라 플로럼 1.0×1010 CFU/mL과 혼합하고 MOI (Multiplicity of infection)를 0.001이 되도록 하여 35℃에서 120 rpm으로 9시간 동안 배양하였다. 배양이 종료된 후 배양액 전량을 6,000 rpm으로 30분간 원심분리하여 상등액을 수득하였고, 이를 0.22 μm 필터로 여과하여 최종 박테리오파지 배양액을 회수하였다. 분리된 박테리오파지를 "박테리오파지 SP1(Bacteriophage SP1)"로 명명하고, 2016년 9월 30일에 한국미생물보존센터 (Korean Culture Center of Microorganisms, 서울, 한국)에 기탁하고, 수탁번호 KFCC11690P를 부여받았다.In order to mass-culture the Salmonella florum-specific bacteriophage identified in Example 1.1 above, the final bacteriophage culture recovered at 1.1 was diluted to 1.0 x 10 7 PFU / mL, and the pre-cultured salmonella flas was treated with 1.0 × 10 10 CFU / mL And the mixture was incubated at 35 DEG C and 120 rpm for 9 hours so that the multiplicity of infection (MOI) was 0.001. After completion of the culture, the whole culture was centrifuged at 6,000 rpm for 30 minutes to obtain a supernatant, which was then filtered with a 0.22 μm filter to recover the final bacteriophage culture. Separated bacteriophages were named "Bacteriophage SP1" and deposited on September 30, 2016 in the Korean Culture Center of Microorganisms (Seoul, Korea), and received the accession number KFCC11690P.

실시예Example 2: 박테리오파지 SP1의 전체 유전자 분석 2: Whole gene analysis of bacteriophage SP1

박테리오파지 SP1의 전체 유전자를 분석하기 위해, 박테리오파지 SP1 배양액에 20 mM EDTA, 50 μg/mL의 프로테나아제 K, 0.5% (w/v) SDS를 가한 후, 50℃에서 1시간 동안 정치하였다. 동량의 페놀-클로로포름-이소프로필 알코올 (25:24:1)과 혼합한 후 실온에서 12,000 rpm으로 10분간 원심분리하여 상등액을 회수하였다. 회수된 상등액을 동일 부피의 페놀-클로로포름-이소프로필 알코올 (25:24:1)과 혼합하여 실온에서 12,000 rpm으로 10분간 원심분리한 후 상등액을 회수하고, 상기 상등액에 3M 소듐 아세테이트를 전체 부피의 10%(v/v)가 되도록 가한 후 혼합하였다. 여기에 2배 부피의 차가운 95% 에탄올을 가하여 혼합한 뒤 -20℃에서 1시간 동안 정치하였다. 반응이 끝난 후 0℃에서 10분간 12,000 rpm으로 원심분리하여 침전물을 획득하였고, 차가운 70% 에탄올로 2회 세척한 뒤 에탄올을 완전히 제거하여 DNA 펠렛을 회수하였다. 회수한 펠렛을 최종 부피가 50 μL이 되도록 TE 완충액 (Tris-EDTA, pH8.0)에 용해시킨 후 DNA 농도를 측정하였다. 전체 유전자 분석을 위해 PacBioRSII를 이용하여 유전자 시퀀싱을 시행하였다 (마크로젠, 한국). 시퀀싱 결과로 얻은 박테리오파지 SP1 유전자의 유전자 맵을 도 2에 나타내었다.To analyze the entire gene of bacteriophage SP1, 20 mM EDTA, 50 μg / mL proteinase K and 0.5% (w / v) SDS were added to the bacteriophage SP1 culture and left at 50 ° C. for 1 hour. The mixture was mixed with an equal amount of phenol-chloroform-isopropyl alcohol (25: 24: 1) and centrifuged at 12,000 rpm for 10 minutes at room temperature to recover the supernatant. The recovered supernatant was mixed with an equal volume of phenol-chloroform-isopropyl alcohol (25: 24: 1) and centrifuged at 12,000 rpm for 10 minutes at room temperature. The supernatant was recovered and 3M sodium acetate was added to the supernatant in a total volume 10% (v / v). The mixture was mixed with 2 volumes of cold 95% ethanol, and the mixture was allowed to stand at -20 DEG C for 1 hour. After the reaction was completed, the precipitate was collected by centrifugation at 12,000 rpm for 10 minutes at 0 ° C., washed twice with cold 70% ethanol, and then the ethanol was completely removed to recover the DNA pellet. The recovered pellet was dissolved in TE buffer (Tris-EDTA, pH 8.0) to a final volume of 50 μL, and the DNA concentration was measured. Gene sequencing was performed using PacBioRSII for whole gene analysis (Macrogen, Korea). The gene map of the bacteriophage SP1 gene obtained as a result of the sequencing is shown in Fig.

도 2에 나타낸 바와 같이, 박테리오파지 SP1의 전체 유전자의 크기는 156,585 bp이며, GC 함량이 44.7%, 전체 ORFs의 수는 201개임을 확인하였다. 분석한 박테리오파지 SP1의 전체 유전자 서열을 서열번호 1로 나타내었다. As shown in FIG. 2, it was confirmed that the size of the entire gene of bacteriophage SP1 was 156,585 bp, GC content was 44.7%, and the total number of ORFs was 201. The entire gene sequence of the analyzed bacteriophage SP1 is shown in SEQ ID NO: 1.

실시예Example 3: 박테리오파지 SP1의 형태학적 특성 3: Morphological characteristics of bacteriophage SP1

박테리오파지 SP1의 형태학적 특성을 알아보기 위해, 배양액을 2.5% 파라포름알데히드-글루타르알데히드(paraformaldehyde-glutaraldehyde)(4℃, phosphate buffer, pH 7.2) 고정액에서 2시간 동안 전고정하고, 완충액(0.1M phosphate buffer, pH 7.2)으로 10분씩 3회 세척한 후, 1% OsO4(25℃, 0.1M phosphate buffer, pH 7.2)에서 2시간 동안 후고정하였다. 고정이 끝난 시료는 동일 완충용액으로 수회 세척한 후, 에탄올 농도 상승순으로 탈수하였으며, 프로필렌 옥사이드로 치환하여 Epon-812로 포매한 다음, 60℃ 오븐에서 중합반응시켰다. 포매된 조직은 Ultramicrotome(ULTRACUT E, Leica)으로 초박절편을 제작한 후, 아세트산 우라닐과 시트르산 납으로 이중 염색하였다. 그 후 투과전자현미경 (CM 20, Philips)으로 100kV에서 120,000~250,000배 사이로 관찰하였다. 그 결과를 도 3에 나타내었다.To determine the morphological characteristics of bacteriophage SP1, the culture was pre-fixed in 2.5% paraformaldehyde-glutaraldehyde (4 ° C, phosphate buffer, pH 7.2) fixative for 2 hours, phosphate buffer, pH 7.2) for 10 min, and then fixed in 1% OsO4 (25 ° C, 0.1 M phosphate buffer, pH 7.2) for 2 h. The immobilized samples were washed several times with the same buffer solution, dehydrated in the order of rising ethanol concentration, substituted with propylene oxide, embedded in Epon-812, and polymerized in an oven at 60 ° C. The embedded tissue was stained with ultramicrotome (ULTRACUT E, Leica) and then double stained with uranyl acetic acid and lead citrate. Thereafter, transmission electron microscope (CM 20, Philips) was observed at 100 kV from 120,000 to 250,000 times. The results are shown in Fig.

도 3에 나타낸 바와 같이, 박테리오파지 SP1은 180-200 nm의 크기로, 정이십면체의 머리를 가지며 수축성의 꼬리를 가지는 형태인 마이오비리데(Myoviridae)에 속함을 확인하였다.As shown in Fig. 3, bacteriophage SP1 was found to belong to Myoviridae, which is 180-200 nm in size, and has a conical twin-headed head and a contractile tail.

실시예Example 4: 박테리오파지 SP1의 단백질 패턴 분석 4: Protein pattern analysis of bacteriophage SP1

박테리오파지 SP1의 단백질 패턴을 분석하기 위해, 1.0×1010 PFU/mL로 준비된 박테리오파지 SP1 40 μL를 10 μL의 5X 로딩 완충액과 혼합하고, 10분간 끓인 다음 12.3% SDS-PAGE를 수행하였다. SDS-PAGE 수행 후 단백질 전기영동 결과를 도 4에 나타내었다.To analyze the protein pattern of bacteriophage SP1, 40 μL of bacteriophage SP1 prepared at 1.0 × 10 10 PFU / mL was mixed with 10 μL of 5X loading buffer, boiled for 10 minutes, and subjected to 12.3% SDS-PAGE. The results of SDS-PAGE and protein electrophoresis are shown in FIG.

도 4에 나타낸 바와 같이, 박테리오파지 SP1은 70 kDa, 66 kDa, 48 kDa, 37 kDa, 34kDa, 23 kDa, 그리고 18 kDa 크기의 주요 단백질을 가지는 것을 확인하였다.As shown in Fig. 4, bacteriophage SP1 has major proteins of 70 kDa, 66 kDa, 48 kDa, 37 kDa, 34 kDa, 23 kDa and 18 kDa in size.

실시예Example 5: 박테리오파지 SP1의 다양한 세균에 대한 감염성 조사 5: Investigation of infectivity of various bacterium of bacteriophage SP1

박테리오파지 SP1의 다양한 세균에 대한 감염성을 조사하였다. Infection of bacteriophage SP1 against various bacteria was investigated.

우선, 박테리오파지 SP1의 살모넬라 플로럼에 대한 용균 활성을 확인하기 위하여, ㈜옵티팜에서 분리하여 보유하고 있는 살모넬라 플로럼 균주를 대상으로 소프트 아가 오버레이법을 수행하였다. 그 결과를 표 1에 나타내었다.First, in order to confirm the lytic activity of Salmonella fl rum of bacteriophage SP1, a soft agar overlay method was carried out on Salmonella flum strains isolated from OptiParm. The results are shown in Table 1.

대상 세균명Target bacteria name 대상 세균수Number of target bacteria 용균 활성이 확인된 수Number of confirmed lytic activity 용균 활성이 확인되지 않은 수Number of unconfirmed lytic activities Salmonella Pullorum Salmonella Pullorum 9 균주9 strains 9 균주9 strains 0 균주0 strains

상기 표 1에 나타낸 바와 같이, 본 발명의 박테리오파지 SP1은 살모넬라 플로럼 9 균주 모두에 대해 감수성이 있는 것을 확인하였으며, 이를 통해 살모넬라 플로럼에 대한 용균활성이 탁월함을 확인하였다.As shown in Table 1, the bacteriophage SP1 of the present invention was found to be susceptible to all 9 strains of Salmonella fl rum, and it was confirmed that the lytic activity of Salmonella fl rum was excellent.

또한, 박테리오파지 SP1이 다양한 세균에 대해서 용균활성을 나타내는지 확인하기 위하여 ㈜옵티팜에서 분리하여 보유하고 있는 균주와 미생물 자원센터 등에서 분양받은 균주를 대상으로 소프트 아가 오버레이법을 통해서 감염성을 확인하였다. 그 결과를 표 2에 나타내었다.In order to confirm whether bacteriophage SP1 exhibits lytic activity against various bacteria, the strains isolated from OptiParm Co., Ltd. and purchased from the microorganism resource center were infected with the virus through the soft agar overlay method. The results are shown in Table 2.

Figure 112016126379302-pat00001
Figure 112016126379302-pat00001

(+: 용균활성 있음, +/-; 약한 용균활성 있음, -; 용균활성 없음)(+: With lytic activity, +/-; with weak lytic activity, -; no lytic activity)

표 2에 나타낸 바와 같이, 본 발명의 박테리오파지 SP1은 살모넬라 플로럼 외에도 살모넬라 갈리나륨 및 살모넬라 엔테리티디스에도 약한 용균활성을 가지는 것을 확인하였다. 그러나, 박테리오파지 SP1은 Escherichia coli, Bacillus cereus, Lactobacillus plantarum 등 살모넬라균이 아닌 다른 속의 세균에 대해서는 용균활성이 없는 것을 확인하였다.As shown in Table 2, the bacteriophage SP1 of the present invention was found to have weak lytic activity in salmonella gallinarium and salmonella enteritidis in addition to salmonella florum. However, bacteriophage SP1 was found to have no lytic activity for bacteria other than Salmonella such as Escherichia coli, Bacillus cereus, and Lactobacillus plantarum .

따라서, 본 발명의 박테리오파지 SP1은 살모넬라균에 특이적으로 용균활성을 나타내는 박테리오파지임을 확인하였다.Therefore, it was confirmed that the bacteriophage SP1 of the present invention is a bacteriophage exhibiting a lytic activity specifically for Salmonella.

실시예Example 6: 박테리오파지 SP1의 pH 안정성 조사 6: Investigation of pH stability of bacteriophage SP1

박테리오파지 SP1의 pH에 대한 안정성을 확인하기 위하여, 다양한 pH 범위(pH 2, 3, 4, 5, 6, 7, 8, 9, 10, 11)에서 박테리오파지의 수를 측정하였다. 소듐 아세테이트 완충액, 소듐 포스페이트 완충액, Tris-HCl을 이용하여 각각의 pH에 맞게 조제한 후 990 μL로 분주하여 준비하였다. 박테리오파지 SP1 배양액을 2.0×108 PFU/mL가 되도록 준비한 다음 배양액을 10 μL씩 취하여 pH에 맞게 조제한 각각의 완충액에 첨가하여 2시간 동안 상온에서 방치하였다. 방치 후 각 반응액을 단계희석하여 소프트 아가 오버레이법에 의해 타이터(titer) 측정을 수행한 결과를 도 5에 나타내었다.The number of bacteriophages was measured in various pH ranges (pH 2, 3, 4, 5, 6, 7, 8, 9, 10, 11) in order to confirm the pH stability of bacteriophage SP1. Sodium acetate buffer, sodium phosphate buffer, and Tris-HCl, and the mixture was divided into 990 μL. The bacteriophage SP1 culture medium was prepared to have a concentration of 2.0 × 10 8 PFU / mL. Then, 10 μL of the culture solution was added to each buffer prepared for pH, and the mixture was allowed to stand at room temperature for 2 hours. After allowing to stand, each reaction solution was diluted stepwise, and a titer measurement was performed by soft agar overlay method. The result is shown in FIG.

도 5에 나타낸 바와 같이, 본 발명의 박테리오파지 SP1은 pH 4-10의 범위에서 2시간 동안 안정한 것을 확인하였다. 이를 통해 박테리오파지 SP1은 pH 안정성이 우수한 박테리오파지임을 알 수 있다.As shown in FIG. 5, it was confirmed that the bacteriophage SP1 of the present invention was stable for 2 hours in the range of pH 4-10. This indicates that bacteriophage SP1 is a bacteriophage having excellent pH stability.

실시예Example 7: 박테리오파지 SP1의 열 안정성 조사 7: Investigation of thermal stability of bacteriophage SP1

박테리오파지 SP1의 열 안정성을 확인하기 위하여, 40℃, 50℃, 60℃, 및 70℃ 등 다양한 온도 범위에서 일정 시간 방치 후 박테리오파지의 수를 측정하였다. 보다 구체적으로, 박테리오파지 SP1 배양액을 1.0×108 PFU/mL가 되도록 희석한 후 배양액 5 mL을 멸균된 튜브에 분주하고 30분, 1시간 및 2시간 동안 각 온도에서 방치하였다. 방치 후 각 반응액을 단계희석하여 소프트 아가 오버레이법에 의한 타이터 측정을 수행한 결과를 도 6에 나타내었다.In order to confirm the thermal stability of bacteriophage SP1, the number of bacteriophages was measured after standing at various temperature ranges such as 40 ° C, 50 ° C, 60 ° C and 70 ° C for a certain time. More specifically, the bacteriophage SP1 culture solution was diluted to 1.0 × 10 8 PFU / mL, and 5 mL of the culture solution was dispensed into a sterilized tube and allowed to stand at each temperature for 30 minutes, 1 hour, and 2 hours. After allowing to stand, each reaction solution was diluted stepwise, and the result of performing a tester measurement by soft agar overlay method is shown in FIG.

6에 나타낸 바와 같이, 본 발명의 박테리오파지 SP1은 40-70℃의 범위에서 안정한 것을 확인하였다. 이를 통해 박테리오파지 SP1은 내열성이 우수한 박테리오파지임을 알 수 있다. 6, it was confirmed that the bacteriophage SP1 of the present invention was stable in the range of 40-70 ° C. As a result, bacteriophage SP1 is a thermophilic bacteriophage.

상기 실험으로부터 박테리오파지 SP1은 살모넬라균에 대한 특이성이 매우 높고, 살모넬라균에 감염하여 균 내에서 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있음을 확인하였다. 또한 본 발명의 박테리오파지 SP1은 사람, 동물, 식물 등 세균외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 SP1은 살모넬라균에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.From the above experiments, it was confirmed that bacteriophage SP1 is highly specific for Salmonella, and has an advantage of being excellent in lytic activity and strong against physicochemical stimulation by proliferation in bacteria by infection with Salmonella. In addition, since the bacteriophage SP1 of the present invention is not infected to any host other than a bacterium such as a human, an animal, or a plant, it can solve problems of antibiotic resistant bacteria caused by misuse of antibiotics, residual antibiotics in food, have. Accordingly, the bacteriophage SP1 of the present invention can be variously used in the field of preventing or treating infectious diseases caused by Salmonella, antibiotic composition, composition for feed addition, feed, disinfectant, or detergent.

비록 본 발명이 상기에 언급된 바람직한 실시예로서 설명되었으나, 발명의 요지와 범위로부터 벗어남이 없이 다양한 수정이나 변형을 하는 것이 가능하다. 또한 첨부된 청구 범위는 본 발명의 요지에 속하는 이러한 수정이나 변형을 포함한다.Although the present invention has been described in terms of the preferred embodiments mentioned above, it is possible to make various modifications and variations without departing from the spirit and scope of the invention. It is also to be understood that the appended claims are intended to cover such modifications and changes as fall within the scope of the invention.

이하 본 발명의 박테리오파지 SP1을 포함하는 감염성 질병의 예방 또는 치료용 약학적 조성물의 제제예를 설명하나, 본 발명을 한정하고자 함이 아니고 단지 이를 구체적으로 설명하고자 함이다.Hereinafter, formulation examples of pharmaceutical compositions for the prevention or treatment of infectious diseases including bacteriophage SP1 of the present invention will be described, but the present invention is not to be construed as being limited thereto, but is specifically explained.

제제예Formulation example 1: 의약품의 제조 1: Manufacture of medicines

1.1 주사제의 제조1.1 Manufacture of Injection

박테리오파지 SP1 1 × 106 PFU/mLBacteriophage SP1 1 x 10 6 PFU / mL

주사용 멸균 증류수 적량Sterile sterilized water for injection

pH 조절제 적량pH adjuster

통상의 주사제의 제조방법에 따라 1 앰플당(2 mL) 상기의 성분 함량으 로 제조한다.(2 mL) per 1 ampoule according to the usual injection preparation method.

1.2 1.2 액제의Liquid 제조 Produce

박테리오파지 SP1 1 × 106 PFU/mLBacteriophage SP1 1 x 10 6 PFU / mL

설탕 20 g20 g of sugar

이성화당 20 g20 g per isomer

레몬향 적량Lemon incense quantity

정제수를 가하여 전체 1,000 mL로 맞추었다. 통상의 액제의 제조방법에 따라 상기의 성분을 혼합한 다음, 갈색병에 충전하고 멸균시켜 액제를 제조한다.Purified water was added and the total volume was adjusted to 1,000 mL. The above components are mixed according to a usual method for producing a liquid agent, and then filled in a brown bottle and sterilized to prepare a liquid agent.

1.3 정제의 제조1.3 Manufacture of tablets

박테리오파지 SP1 1 × 106 PFU/mLBacteriophage SP1 1 x 10 6 PFU / mL

옥수수전분 100 mgCorn starch 100 mg

유당 100 mgLactose 100 mg

스테아린산 마그네슘 2 mgMagnesium stearate 2 mg

상기의 성분들을 혼합한 후 통상의 정제의 제조방법에 따라서 타정하여 정제를 제조한다.After mixing the above components, tablets are prepared by tableting according to the usual preparation method of tablets.

한국미생물보존센터(국내)Korea Microorganism Conservation Center (Domestic) KFCC11690PKFCC11690P 2016093020160930

SEQUENCE LISTING <110> Optipharm.CO.,LTD <120> Novel Salmonella specific bacteriophage SP1 and antibacterial composition comprising the same <130> 30 <160> 1 <170> PatentIn version 3.2 <210> 1 <211> 156585 <212> DNA <213> bacteriophage <400> 1 gttgtggtaa atatattaca gtctatagga gaactgatca tggcgaagac acaaaagaaa 60 attgaaaaca ctcaaaccat tcaagaaatc actgcacagg aagaaaataa acttcccagt 120 tatctgcaac gcgtggtgga taacgtgcct cagggcggcg acggcggtat tgtctacgct 180 ggtgactacg gttgggtgtg tgaatataaa gacggctcta aggagcttct agaggaactc 240 accggacttg ccggaacttt gcgccgttat gggttagata aattcggtaa acctatgaaa 300 ccaggtactg tggtatcaac cgatattaca gttgaagttc ttcttttgct tgatatcaat 360 gatcttaaga cacttgcgga acccctgggt atcgacgcga ctgaccgtaa tgaaataatc 420 tcgcaattga ctgaaaaact gcagattaaa taatcccagt gtataactgc tgattataat 480 tcaatatggc tatcgttgac gaaagcaatt tgatggagta cgctctaaga cattatatca 540 cccctggtgt ctcaagagat gatttgatgg tagacattca gcgaatttcg ctaattaatc 600 aatcattgaa aagatttgtg ccagggaaaa gtcctcgcgt acttatcaat caattgatta 660 ttcttttcaa tacctttgaa accgaagccg tgtgccgaat gttggtgttg aaaacggata 720 agaaccaaca tcctcgtctt aaagcagcgc tgttgacgtt aggagtttgg cgagatgatt 780 tatgttccgg ttcatacgaa ccagataatg agctgatgat ggctctgaac aacgatttgg 840 atgagtggag gaaaccatgc caacaatcac agtattagtc gcaccggaag ttgtccgcaa 900 caaacccgaa accgaacgca atcatgtcgt gacgggtgtt gcaaagggtt ggcaaaagac 960 cagcctcaac caagatcctg acgagatcct gaccgaatgt aaaggtcttg acgctctgct 1020 caccaagagc aatttacaag cggacggtgt caccaaagtg gatcccacca agcctatcgg 1080 ctttcaagta tcttatgaaa tccacgatcc gaatgccatt ttaaccaccg gacttgtgat 1140 tactccagct acagccagcg gagagatcgg acaatttgtt gaattgctag cgacggtatc 1200 ccctgccaat gccacatatc aaggcgttaa ttggtattct ggtgatatta cgaaagctgt 1260 acatgtcggt ggtggtaaat tcaaattgct ggcttcagga actgtaacgg tttatggtgt 1320 cacggttgaa gggaatcaca cagattctac ggttattaca gttgcaggcg ctctatcgct 1380 gtcgactgat ttacctgcca ccaaagacgt aacttctgga caagacggaa cctttagtgt 1440 tgttgctgcg ggcggtacaa ctccatacac ttatgtgtgg catttctctg atactcctgg 1500 gggtgctggg tcagttatcg atgctggcac taatgccacc gccgccactg ctaacctggt 1560 tatcacagca gttgaagccg caaatgaagg cgaatattgg tgtgtggttt ctgatgcaga 1620 tggccattct gtcacgtcta ctcgttgtga aatggctgtg gtgtaattta tgaagagctt 1680 ccaggatttc cttgaagact cttctgctcc ggcaaccacg accgccgatg tggggaaacc 1740 cgaaggcggt atggtcaagg agcctgtcaa aaaaccaaaa gatcttgaag aagagtctga 1800 ttttaaaaag atctttggca acattttcaa agatttggat ttatccaagg cgcgaaaatg 1860 gaatttcagg acaggccaat acgacgatta aagaggcttc ggcctctttt tcatttccag 1920 cattgggtgt ataatggacc cgttccccat gagcggaacc taactgagga tataccaaat 1980 gcaatctatg atcaaacgta aaatagaaat ctctatgaat gcccatgtcg atatgatcca 2040 gcagcttgtg gcagatgcgt atgagataca aaaggaacgt cagattaggg gagtgataga 2100 ccctatttgc tccggcaaca tgctctacta cagaatgctc cgccagaccg gacatacagc 2160 cgctctgaag aaactacttt ctaaaaagtt tcaggtcgaa aacgacgcat atgtgtttgg 2220 cgtcttccat acttctcgtg aacgtgatgc attcttctat ccttcccgca accctcagac 2280 gggcgaagaa ttacttatcc ctgatgtcga caagaaagag agcacgacga caatcaccca 2340 tttcatgggg accaggatcg ataaggctaa cataatcgtg ttctctgaca ctctacatga 2400 tgtaaaacgt ttagccgctg cccgtgaaat gttgcaggat gctcggacca gtctcacaaa 2460 tttgacttta gtagtgtttc tgggctagat atctgtgtgg ggagagaact ccccattttg 2520 aatcggaggt gatttatgtt acgttgcaaa agaggttcca actcctttaa gttgggcatg 2580 ctgactggag taacgttcat gattgcttta gacagccttg tgggactgct ttccctacct 2640 gattttagga tggaacgatt catattgtta gttctatttg gcggcgtctc tattatctgt 2700 accctgaaag catataaaaa gatttgacct gattacacac agcaattttg atttgagacc 2760 ctatatcatg ctcccattac tcaatgttcc aaaagaacgt atgacgccgg atagtgaagg 2820 caagacccat tacaacatat acagtcgaag ccgcacagaa ctaggcagat ccctttccca 2880 ttttgcatac catcccatgg atactgttga tggtaatttc aactcaatag aaggctactg 2940 gtattggcta aaatatcgcc acgacgactt gcgtagtctt tatgggaacg acgccaagca 3000 atttggacaa accctggcca agtcacgcat cgttgtattg tcccctgatg atcccaaatt 3060 taaaagagac attatcgcag cgacgagtca aaaattgctg acaatgccat ccaagttgag 3120 attccaattg gctcacagcc gtcttcccct gattcacgct tatgaacatc aggggaaata 3180 cagttttcaa aactctatgg attttatcat acagcatatt aaccgcttcc gtctagaagg 3240 atatttgaaa tgaattttct aaaaactatc ttcaacacat catatgaact cagccagcgc 3300 gatcctaatc gttctcctgt gtttgtatat tgcaaactcg tggaagagtc ttgtgaacta 3360 tcagatgtgc tttatggaat cgctgcatcc gaacccctga acggtgaagt ggcggacgtt 3420 atcatctcgg ctctggatct attatatgtt gtggattatc aacaagttca acaacatggg 3480 tctatgacca aagaagaaat ctttgactcc atgttgtttg ctttggctac agccaatcac 3540 acaactgatc tcagccaaca tacgttggag gattattggt tctgcagtgg tgttgaaact 3600 atagacaaat atcttgcgat ggttaatcat tacaaaggcc gcatcactcg tttactgaac 3660 caacctcaac gttcggaaga taatatggtg gacctggttt caaatctgat acgcaatact 3720 gccaaattgg cgtgtgggta taatcaaaac catatcaaca cgatcgttaa agtagaacat 3780 gccatagaac acaaagttga aaagtggcgc actaaatttg gtctataagc caaccccata 3840 cataatcttg tgtgtttacc attgacggga taggccgatg tccaacaaaa ttgatattga 3900 acgcaaatac aaaaagctca ctcacataga gcatatccta cttcgcccag agcgtcatct 3960 gggcagtatt cgttcgtctg tggggacggt gtgggtgtat gacccaacca aagacaaagt 4020 catctttcgt gacaactttg agtactcccc tgcgctgatc aaacagtttg atgaaatcat 4080 caccaactgt gttgaccaca gcaagacccc tgagggtaaa ggcttgacgg aaatcaccgt 4140 cacggtctcc cctatgaacg gtcaaatcat cgtttccgac aacgggggta tccctgtggt 4200 caagcatggc gtcaccaatg agtggctccc tgagatgttg tttggctcgc tctatgcggg 4260 cagcaacttc aacgatgagg acgaggagta caacaaccag aagtccggcg gccagaacgg 4320 tgaaggggct tcgctcgtca acgtgttctc aaagtggttc cgcgttgcta ccagtgacgg 4380 caagaagtct tatactcagc tgtttgaaga caacatgagc aagaagtcca atccggtcat 4440 cggcaataca ccgaaagagt tcggcaccac tattgcctgg atccctgatt atgcgcgcct 4500 gggtgttaag gggcttgacc agaacaacct gctcatgatt taccgtcgtg cattcgaagt 4560 ggcggcatgc aacccgcgcc tgaaggttgt tctcaacggc aagcaaatcc gcattgatcg 4620 atttggtcat ttcgttgatt acttctacgc tggctcggct gttgatgaaa cggatgattg 4680 gtctgttgct atcactccct catctggtgc gttcatgcat gcatcatacg tgaactcaat 4740 cgccacgcac atcggtggac ctcacgttga ttatgttgct gaccagatcg tggcggcgat 4800 acgccctcag ctggttaaga agttcaagac cgaactgaag ccagcgatga tcaagaacca 4860 catgtcattg ttcatcgccg ccgacatcaa caaccctcgc tttgacagcc agaccaagga 4920 gcgcatgacg actcctgtga gccagtttgg tacgtcctac aagcccagcg ataaactgat 4980 tcgcaaggcg cttgagttcg tgacagcagg gctgagtaaa gaactggctt cattacgcaa 5040 tgaacaagaa gatgccgaat ttgaaaaggc gaagaaggat atcagcaaac gggattatcg 5100 tgagattgag aagtattatc cggcgaccgc cagaggcgac cgcagtgggt gttcgctgct 5160 actgacagaa ggtgatagcg catccaaccc tatcctgaac gctcgtgaca ccaagaaaat 5220 tggtttgttc ccgcttcgtg gtaagtttat caactgcttg aacgccccgc gctcaaaagt 5280 gatggcgaac gaagaattca agaatttatg caccattcac ggcggtgctg tgccaggcca 5340 gccgcttgat atcagtcgct atccacagac cgtcgtggca acagacgcgg atgacgacgg 5400 cattcacatc cgtgggttgt taataactct gtattgtacg ttctggcctg aatacgttcg 5460 tcagggtagg ctgaagctcc ttcgtacccc atacatgcgc gtgtggtgtg gtaatataat 5520 gcatgaattc atgaacaatg ccgaatatga ggagttcctg aagacacctg acgccaagaa 5580 gatcacgaag aagaaatatc tgaaaggtct tggcggtaac agcactgaag acttcaagcg 5640 tattctaaac aacctggatg cgtatactac gacggtcacg ctggacgatg gatacaagca 5700 gtcactgaag aatggcttcg gtgatgaggc cgccgattac cgcaaaacct ggtttagcga 5760 cgtttgcctg tttgaaaccg aggatgaata agatggttgc caagagcatt actgtaacgg 5820 actttgtcaa cactgaccac aaggagtttt ccgtggtcaa cagcatccgt caaatccctc 5880 agctgattga cagcctgaag ccaagccagc gcaagatcct cttcgctgct cttgaataca 5940 acaaggagga gattgttgac cgccttggca tgttcgccgc cgctcgcacg aattacaaat 6000 ccggtggtga gaacatgagc ggtacgatcg tgaacatggc tcaggggttc ccaggtacga 6060 ataacatccc atactttgac cgcgacggac agtttggttc aatcatgggg cgcgaagcgt 6120 cttccgctcg ttatatttca gtggcagtgt ctgaagttat ccgtaaaatc ttccgaaagg 6180 aggacgatgg gatattggaa tacaattatc ttggggaaga gaaactggag ccgaaattct 6240 ttttacccat cctgcccatg tttctcgtga atggtatcaa tggtatcgga tcgggttatg 6300 ccaccgacac cccatgtcac tgcgttaagt ccgtgctcag tgccctgaga gcacttctcc 6360 gtggcgaaga cccgaaggac ttaaaaccgt actggaatgg tttcaaagga gagacaggct 6420 atactgagga aggaagagca tacagtcgtg gattgttcac ccgcgttaat gcaaccactt 6480 tgaacatcac cgaggttcct attggttggt tctctaaaac ctatgagacc aaagtgctgt 6540 tgcccctgta caaggcggga gtcctcactg agtacgccaa cgatacgacc gaagatggtt 6600 gggatatcac tgttgtattc aagcggggtg aattgtctaa gttgaatgac gaacaggttg 6660 aacaaatgtt ccgcctctac tcagctaata agcccgtgtg gacagcttgg gatgaagatg 6720 gtgttattca ccgttacgat ggttggaaag atatgttgct tccatttttc aattatcgcc 6780 tgagtcgcta tgaagataga cgtcagtatc ttatcaagga attgaccgac aaaatacacc 6840 gtttgaacaa tcgtgccata ttcattgggt gggctgtcgt tacagatatg cgccggagcc 6900 tcacggaact gaaagcgtta ttccagacag actatcctga ttttgatggc gatctcgatg 6960 atttattcaa gatgtcttta tcatcaatta cactagatgc ccgtgaacgt ttgttgaacc 7020 agataaagaa tttagaagtt caacgagaag aattaaataa taagcaagac atcgatcttt 7080 atactgaaga tttagatgat cttgaaaagg cattgggcct ataaatctgg agggtgaatt 7140 ccctccaaac aagcgagggg ttcaccatgt ttgtatattt ccgcagtctc tcattgctgg 7200 ctttcttcta ttggttgttc gatatcttat gccctcgttt tattaaagat gaagttgctt 7260 ttgtcaatca tgaaggtcaa caagatttat ggatacctct ttgcgctctt tctgatgtaa 7320 ccgaatcgga tgaagtgggt atggttggca ccatgcgttc atttaattta tttggattcg 7380 cattattccc taagttaatt ggagaattac acccatacaa tcctgatgaa gaagtggagg 7440 cgtgatatgt caaaattatt gactccaaaa ttattatcaa tgggtggttc catatatttt 7500 cattgtcctg gatgtaatat gcttcatcct tatcgcattt cagggcaaat gcctggccca 7560 atatggcaat ggaatcacga tctcgaatca ccgactttca ctcctagtct gttggtgaat 7620 cattctgatc caaataaccg ttgccattta tttttgacag atggtaaatt acaattcctc 7680 ggagattgtt tccacgaatt aaagaatcaa accgtggaga tggtcgatat tcctgaacct 7740 gaaatatgga tagattagat tatgaaatta cttggatatt ttcgttcttt acctactgga 7800 tctcctaatg ggtgtcaatt atactctgaa gtgaaagggg acgtgaacga cactcacatc 7860 gccttgtatg ctcgtgatat acctgaccct accaagtttg atcggcgtgt tgtggctgct 7920 gccaacaaat atggtgatgt gatcgttgta agcgcccgac atcacgacaa attgatgaac 7980 acgcaactca aacgattgaa ggaagcaggt attatcgaaa ccacccacac tcgtgaacaa 8040 gggtttattg ataactatgg gcaatggatg tcccgtgaag aggccgctgt ggtcgcccgt 8100 gaagccggac aaactaatca ggtccgtttg aagaacactc ctttcaaaaa actcttttcc 8160 gaagacctct attgaataaa ttggcggtat aattgccgcc taaccccata atgagacaaa 8220 taacatggca aatgaaattg gtgatattgc ccagttccgt gctatttcac gccgcctgaa 8280 atcgtatgga ctcgtcatcg aagaaataga tgaagatgtt cagggtgtat tggaagggat 8340 gtttgggagt accgttggaa cggaattatt tgaactttta aagatggcag ctgataacca 8400 atttgttgaa tatatttctg aacacgctat tgatggcctg aataaatgaa cgagttatat 8460 gaatttgaac gcgtgtatga gtccgcttca gtttcaggat acatgaaacg attatatcaa 8520 gaaatctgtg ttcgtttgat gatgcgagga atatctgtca attgtgttat ggcacagaca 8580 gacagtttta ttatgacact cactgaccat cgccagaata tgtgtatcat ccaggttagc 8640 tgtgtcaaca acgaaattat acaatggaga cgttacgcat gaccacatat gttatcacaa 8700 acggcgattt actgaaagcc gctacgagtt ttaatctcat caatgctttc gctcatggcg 8760 caaattgttg gtctgtgatg ggcgcaggta tcgccaacca tgttcgattg gatttcccag 8820 aaatttaccg cgccgaccaa ttagatgaac gtggtccgga acaacgtttg gggaacatgt 8880 cctatgcgtt tgatcatgac actggtgtct ggggattcaa tttgtatact cagttctacc 8940 ctggtcctaa cgcacgcatg ccttccatta tcagttcagt tcagattatg tttgaacaag 9000 ttcacgatat cattgaggca aaaactgacg aaacagtcta tgtcggttta cccgccatcg 9060 gctgtggtat cggtggtttg aaactgtttc atgtagtgag ccagattaat aaaatcgcgg 9120 atactatctt cgaagatacc aggcgtcgtg tagtacccgt cttttatatc cgacagggtg 9180 acgggtttga acaagattta caagaacttt cccagatggt ggactacgga atctctgtcg 9240 tcgctagtga agaagatatc atcgaagagg aaggtattgg atgaagcgtg aaataacaga 9300 agagatgctc gccaaagccg ttcttcatcc caaggtgcgt tttgcattta tccctacacg 9360 tttacacgat ggaaattggg tatggctgga gcattacgtt cgcgctccta tcggcctata 9420 tgcccaactc cgttatggcg gcgaagtcga gttaaaacaa tatcgcgtcg gcgggggatt 9480 aggcgggttg gatgacgggg aatatttccc acatcgaaat ttcgccatga acgataattc 9540 atatttcaaa gtcgagtatg ccaccgcttg tgggacatat cctttgaaac tccttttaga 9600 gaaagcaggg gaaactgatg tataaatcta atttcttggc cgtcgctgat agcgaaactc 9660 tcggtcgttg ggatgatgct gtcatgttgt cttgggcaca gactatcgcc gacctgacca 9720 agcgttatac ccttcagcag cttgttgaag agcgcacgac atttatcaaa ctgaatgtca 9780 aagaacagat tgaacttggc cgtgtgaaag accagggcac tgtggaatgg tggctgggta 9840 caggtaaacg caacccgtgc gacgccgccc gagctatcag tctatatccg accgacaagg 9900 atatttctat tttcgaattg gccgatgaaa ttcgcaaggg atgccatcgc cttgggatcg 9960 acccgcgctc ggttgactgg tgtgatagga atctgtttga cctccgcaag gctcagcaca 10020 tcattgaggt gacgtgtaag caagattcca acgaaccttg ggactatcac cacacatttg 10080 acatcgtaag ctggctgaag ggtgttgggc agcaggatcg atatgctggt atcaaggcgt 10140 gggaactgga aggcatgatc tatcatgacc ctcgttatga tgcggcgctt gactggctac 10200 gcattcagaa aaccatggaa gacctgatgg ggctgaaggt agaaggatga atctttcctt 10260 gttttcatgg ttgtttacaa tcatagtttt cttcatagtc tgtgttcaat attttggagg 10320 ttcttaaatg ttctttcaaa ttgtcggggt gatcacgacc attgtttttg ttgtcataac 10380 gctttggata ttgtattttt catttatcca tccgattttt caggctctca gtattacgcg 10440 ttggctcaca gcgtgttctt tgaaatccgg aagcgaatgt ccttctttat cgtccaaatg 10500 gaaattcttc aaatgggcgt atgaagtcgg aggagtccga acaaccagat attcaaataa 10560 tgtaggggaa tggtttagca tcggcaattg gcgtttgtac gaatctgaag acaaataagc 10620 cccgaaaggg gcttttctat ttgtataatg tattatcatt gtaccatcat atctttatgg 10680 cacacaacaa atgaaagagc aagaaattat ccagcattgt attcgcttag gaacattaaa 10740 acctctctat caggctttgc gtttcaatgc cattaaattc aaacctttac caagaactat 10800 cgcaacgttc tttgccatgc gttctgttgg aaaaacgatt ttctttgagc atgacattta 10860 tttttataca aagattaatg gcgaagattt agataaaatg attttcgtga acgacgataa 10920 aaatatgaag ataaaagtgg aaaacgaatt gcgcaggata aatgattctt taagaggaat 10980 attttaatgg aaattgttgt ctcaatatct gattgtgatt ttgtataccg tgttcttcaa 11040 ggggatgctc cattgccgga gaataatcaa gaagtgacgt tgttctggtc tggtggggtg 11100 gatagcacat acatgttgat ttggttgtta tcgaaaggat attcagttca tactgtgtat 11160 tgccacctcg aaaataataa atttaaatct aaacgcgaaa attgggcgag gaataaaata 11220 cacaactgga ttaataaaaa tgccccactt ctcatgtatc gttggacaca tcatcaagaa 11280 cctatcagta gcatcaacgt cccgaacggt ggttttcgcg cttgtttagc acaagccccg 11340 atatggttat taaacacgca atttaaaggc agtggcttgc cttccacgta tatcttggca 11400 tatgttaacg gcgatgacgc aatacactgg atacccgcct ttaataaagt tattgaagga 11460 tacaacatga tgaccagaga cggggaaaga tctattgaaa ttttatatcc attgattagt 11520 ctcaagaaat cttggttcta tcatcacatg tccccaatac atgacttaat gacatggtgt 11580 gaattgccaa ttttgaaaaa gaattgtgat tgtcctgcgt gtgttcgaca tcgccatgag 11640 ttatcataga gatgaaacgt tcagttgttg taaatgacat cacgagattg ataaatctta 11700 tcaaagacgt cttcccacaa caggtggatg ttgagtatgt tgggaagaac ggaaagtgct 11760 atcaggttgc tctggttctg aagcatgtgt atcctcaagc agagatccat tatagccaga 11820 ttgaaggtca tgtgtatact ctgattgacg gacattacta cgacatcgaa ggcatccact 11880 tcagtgtccc accagacacg tgtttgctcg aacataatag aggtcacaaa ccgcatcgtt 11940 ggcataaagg gtttgtgaac gtgccgattt tagaatggct gaggaaacca taatggcggg 12000 aattgtaaag caccttggtg acactcatct tgggcataag aaggtcttta aaccgcgtgg 12060 atttgataca caggaagcgc atgacgctgc ggttatcgac acgatcttcc aggggctgaa 12120 gtctcgggac gtccttgaac tggctggtga tatatgcttc atcggggctg aagggttcat 12180 tcgcctgatg cgggagggtg ccaagcgaaa cattgatgag tttaagcgac accccgtccc 12240 cgatgactgg cgtccgaact ttatcatcag ggtggcacag ggcaaccacg acagctttaa 12300 gatgctgttg tctttgtata tggacggctg gattagctcc ttcggcgcta tgtacgaacg 12360 tgacacgcct gttggccgtg tgttgacaac acatgttcct tatcaattag accgttgggt 12420 gtataatatc catggtcatc ttcacgaaaa tattcgcgaa gagcgcgaat acctgaactg 12480 cagttgggaa caattcaagc gtcctgtaac cctggctgag ttgttataca caaatttagg 12540 aattgtgcta tgagaatatt ctttcctggt cagaaagtac ccgaagaaat agaaaaggtc 12600 gagttatttg gttataaaag cggtgatccg ttcctgcgat tttcttcacc atgtatcgta 12660 aagcgcaata atgaaggata ttatgtgcgc ccaatcattc tcatgggttc tgtcatgaca 12720 ctgagagctg aaacggattc ggttgttatt actggaagtc ccaacatacc caatggaaag 12780 actacgctaa attgcaagcc tatcctgtcg tcttggatgt taattggatt tctatctgta 12840 gtcctgtctt atcgttacct tactgacttg gggatcttat gaaaaagcca agaatcacag 12900 gacatcaact ctgcgtcctt ttaggaatgt taaattttga aaagggtgaa gccagacgcc 12960 tttgtcattg gtatttcaat ccgaagtctt ggacgaatga aaagggcaag acagtatgga 13020 cattccatac ccctccgatt gctggtgggt ttcgttctgt aaaaggtgat ccgtgggata 13080 cacgttcagg gcaatcatta ttatctaaag gtctgatcga acctgcgttt acaatggttc 13140 atgacaactc tgaagaatat aaacattggc cgaagtctga agtaacattc taccgcctga 13200 ctgaacttgg tcaagcttgt actgaataat aatttatttt attgaagaag gggaaggtat 13260 actttccctt aatttattgg gagagataaa catgatttca ttaaaagaaa tgtacgaacg 13320 cctcgaagaa ctgaaatcta aagaacgtct gtattcagaa gagaacgcag aaatgtcaga 13380 tcttatcgaa aaaattgcgt tgcgtgaaaa gtatcttcaa cgttatatca atcatccacc 13440 tcatatggtt gagcgcatgt ctacaattct cgaattggac aacagcggtg taacaagcaa 13500 agacctgatt gtcaaagagg ttcattccat ggtgtccctc ggtcagatct ttggccgcgc 13560 cgaccaggat gacatgatct ttttacttga aaaggctctg ataaaataat ggctatcaaa 13620 ccacgtatga tgtttgctca tatgcgatca gctgcagcat atggtgtaac cagttatgct 13680 cggcgtctgc aagtcggttg tgttatcgta aaccctgaaa ctgatcagcc tgtggctatc 13740 ggatggaacg gaacgcctcc tggcatgccg aatgtttgtg agatggaaca acacgggcaa 13800 attgttacaa acccgtgtgt cattcatgcg gaggaaaatg ctctaatgcg tatccccgaa 13860 aatgcagatg atttcacagg gttggttatg tttgtgacac atagcccatg ccctgattgc 13920 actcagaaga tcatcgacaa cggcaagatc gataaagtat attatcaaga gccatatcgt 13980 atcatggatg gaatcaaaag attgatgaac tccggaattg aagtttaccg gatggtgggc 14040 gatatggcaa tccttaaaca cgttttcgac gatcaaggcg aagtcggata cgaacaaatc 14100 ttatccaacc cagacaaagt aaggaattaa aatgcgttat gtagaccgca tgctcggcga 14160 aaatgaacat gtcatcgctt tcacccgccc gacttggtgg agcggttttt ggatttatgt 14220 tctggttatt ttaacgatta tcccaacatt tggattcagc ttgttatttc tgataccaac 14280 aattttaaat gtgttgacaa ctgaattcgc agtcaccaac aagcgcgtta ttgtcaaacg 14340 gggatttatt cgtcgtgatg ctgatgaact ccgtcttggt aaagtagaaa ccattaaggt 14400 ggaccagtct attacaggcc gtatcttgaa gttttcgacc atcagtgtta ttggtacggg 14460 cggtactcgc ctgttggcta caggttgtgc taaagggaac gaattccgtc aaaaaattta 14520 tgatcatctg ggtgactaaa tgattactgc aggatacacc gtcgatttgt attgtgagtg 14580 tgttgaatgc aaatcttgta attgggcttg ggaagaacat caccccagat gtgggatgaa 14640 gtcttatgct ggtgaatctt ggggagactg tgctagacaa gcccgtgctg atggatggat 14700 gatatgcagg gacaaacaaa cttgctttgc ccctggacat ccaaggaaat cagggtaata 14760 acaaaccatc atcttccgat tgcgttggtt gtttattagc agtttccttc ttcatttgct 14820 ctttcaacgc attaatcctt tgagcgcggc gtcgatcttc catttcgact tcgcgctttt 14880 tcttagaacg aagagcaaat tgttttttaa cttctgggtc ttcacctggc accaaatgtt 14940 cttctgtcca gataatgaat ttccaaccta cctttgcgca atgttcttta gttgctgtcc 15000 actttgcctg atttaccaac caagtgcgca ttgaattatt gaatgttgat tccttcatcg 15060 ttttagtttt gcgaggttct ttaatctggt ctttgggttt tatttcaata agagtaattt 15120 gtaattcatc ggaatcctgc cgacgagtcc aaaccttcaa atccatgaaa taacgatggg 15180 cgcggccatc aaccggagat atgtaaggga ttacagtttc ttctgaagac caatagacga 15240 tagcaggatt catatcacaa aatttaaagg cgacaagttc tagcgaagaa cgaaatacta 15300 ttttgttcac gtcgccttta tatttcttgg gatttacggg aacatacttc ccctgcaaat 15360 acatagccat attctagtcc taaatagtgt catcactcta ttctaattaa agggcttcag 15420 accatggcga atttcaagtc gaccatcgat aagatcaaag ttctgaacac aaaaggcttg 15480 gccaagtctc agaagcaatt ggtctatcca ttagacataa cagggggtaa aaccctcggc 15540 cattatgttc tattcaacat caaccgaata tctggttctt catatggaga caccacaacc 15600 caaaccgtcg aaaatccgat acaaaatcca ttgggtaaga ctcctgtggt ttacggctct 15660 aaatcgggtt ctattagcaa atatgcttgg gcgcgtcatg tccgctctaa cgagtcaatt 15720 gtgttgtgta tgcccgaatc cattacaacc aactatggcg ttggctggaa cggctccgag 15780 ttgggattag caggtatggg tgcccaattc ttatcacgcg ccgcccaaga tatgagtcaa 15840 ttcaaacttg gggatgcttt gaatgttggg aaagaaatgg ggagatttgc ggcaacaaag 15900 gccattcaat ctgcttcgga agcaattcct ttcttgccga caattaatgc tcatgataca 15960 ttagaattgt ttacaggtac gatgaccaac ccgtatgtgg aaatgatttt ccaaggggtg 16020 cgcaaccgag aaatcccgtt cacattcaaa ttcactccaa gatcgcaaaa agaggcgaaa 16080 atggtgcggg agattatccg tttattcaaa atgcacatgt atccagaata caaatacaac 16140 aagaattcca gcgcattcta tcttcatcca tccacgtttg atatcacgtt catggtccag 16200 ggagaacgca acaaatggtt gcatcggata tcgacttgcg tcctatcaaa tatgtttgtc 16260 aacgagacgc ctgactcttc atatgctgta cacaaagatg acagcatcgt gtcgacacaa 16320 atcgacatga cgtttataga actagaaccg ttgcacaaag gccgctttga taccgaaggc 16380 gacagcttct aaggagaaga tgccatgaaa tattttgaga aatttccact cgtatggcat 16440 caactaattg gtgtcaaaga ggatgaccaa gtcctgttgc agaacttaac acgacgggtt 16500 atggttgtta agaaaattag ggacatagaa gggcttctcc tgccgtatac tgtttttgat 16560 ggggaaaccc caaggtcttt tgccgaacgc gtctacggtt ccttcgagct gttttggatc 16620 ccatgtctta tcaatggtat catggacatc gtagaggact ggccgaaacc ggagcgccgt 16680 atcattgaag aactgactgc tcgatacggc cttgacggaa tgtgggatgt gaaatactat 16740 gttgacgaat tcggtcatga aacagatcct agagcaatac gtttagcata tggccttggt 16800 tctatggatg attccacgat tatcaccaac tatggtctga caggtattac atatcatgat 16860 gatgctataa acaaaaacga agccaaacgg aatattcagg ttctagaccc agattatgtt 16920 tcttcctttg ttaatcagct ggaacaggag ctgaccaaat gatcgaaaat aaagaatccc 16980 aggacggaat tttaactccg tccacaacat ttgatttgaa atatatggcg atattaccac 17040 acacgcctga aggcggtact cccaagcctt atgacctttc atcgttgttt caagaattca 17100 acgtatatca ggatcttggt ctggaaggga atgcttcacc gtcgctgaca gctaatattc 17160 tgatcaaaga aggctgggat atattggata caatgccaat cctcggaggt gaggaagtag 17220 tggtatcgtt caaatcgcct gcagcttctg attacactac gctttcattg cgagtcagtc 17280 gggtagggag agttgctgat gaatcgaact cttcttcgaa aaaggcattc tggttacact 17340 tggtaacaac agacgcgtat cgagatagca tgttgcgtaa atctcttgga ttaagcggtt 17400 cttattctga gatggcagct aagatctttg agcaactgaa ttcacgcacc aaatttgaag 17460 acatagatcc ttcatatggg atacaagaaa ggttcgctac ccctctttgg cctgtactcc 17520 gctccataga ttatatggcc agccgtgcat atgacgaatt attcatgcca ttcgttttct 17580 atgaagactt tacgggttat cacttcaaaa gcatgacgac gttgttcaac cagggcaacc 17640 agtctatgac tgctgaagag aagcaagagg cttctattga aaagaaattc ttccgagacc 17700 ctcaagacgc gccgttgatg caggataaca atttcaactc agaacgtttc atgcggacta 17760 tcatcaaggc tgaaaagaaa ctggcgcgtg atcagtacat ggcgaattat cgggatatct 17820 tggcagtgaa cgagcgcgtg tatgacttta gtacaaaatc cacgacagcg acccaacgca 17880 tttattcaga atggtttgac agcacggctc accttgatcc gttcccgtta ttctcggatc 17940 aatttgatcg tgaaaatgtt cgttatatcg aggcacaacc agatggagct gaacaaatag 18000 attatgctcg ccgcgtaata gaattcagtc tagcatctac ggttatgcgt ttgctcgtgg 18060 tcggcgataa ccgcctgaac gttggtcagg tttattatat tgaagacttg tctaaccgcc 18120 ctaaatctaa tgaaaacatt gccgagttaa gtaagttatc atcaggccac tatattgtca 18180 caaagatacg ccataagatt tcacgcctga caaatgatta tcaatgcgtc gccgagattg 18240 ccaaagacag tatgatccag aaggtattac cacctcagac tggacaaact gtggcttcta 18300 acccaacccc gacgccaaca gagaaaggac aagcccagaa ggtctgagag gtgacaaatg 18360 gcagataaca atcaaccgac accagggcag caggacatcg tcaaggtctt ggataaaatc 18420 aaaaaggaaa tgatggagcg caagcaattg cgcgcccaat ccgagacgaa taagcagctc 18480 gctgatgtca acaaacaact gcaatctctg aagacaagac aggcgtctaa tcaggagcag 18540 aaagtccctc caatcaaatt cccatcggtg aatgacatcg ttggtgggtt cgttcgcgtt 18600 agtcctattt tcacaaggga ttacagcact tggatgaaag acactgtcag cctttccaag 18660 gacggaaatg aagaactgat gcgaatcgca accaaaatag aaaaatttgg cgaagcggcg 18720 aatggccctg ttgatgatat gtctgttgaa tatcttgaca tgatatcgga tcaattagga 18780 gcagcgaatg aagatagtct agaacgtctt gatggattac aggacaaact agcactggtg 18840 ggagggaaga ttgtaaacct gaccgacata atgcttcaga ctcataagga cacgctggac 18900 ttcaataaag atgccaacaa cgaaaccgtt actcgtcttg acagcattga tgataaattg 18960 gggtatatga atgaagacct caatgacaca ttaacgcgta tctatgagag tgatcaaaaa 19020 tatcgagaag aagagaaatt ccggcgcggc gaagaaggta aagagaacaa gaacaatccc 19080 gaagcaggtt ctattccacc ttctgaacca aaacaggacg ggcaatcttc cggtatgggc 19140 gcggcgctgg gtgcacttct cggcttggga gcattgaaac tcctgatgtc tccactaaaa 19200 ctcattggag gattcatcaa gttattcatg ggattcggga tgggcatcgg tggtctattg 19260 aagcctttga aagcagcgac caaaatgctt cgagtcggac ctttggctct gataacatct 19320 gtatttgaat tcggtaaagg tttcttcaat gctaaagaaa tccttggcaa agcccaagtt 19380 tcaatagtag acagggttca ggcgggcata acagaacttg ttggcagttt cggagatctg 19440 gctgattggg tggctgaaat atttggttgg gataacgcag gatttggaaa ggcgttccgt 19500 gaacaagtat tgaagatgac cgaagcacca gtgcgctggc tcaattctat cgttgattgg 19560 gtatccaacg atctgtttgc tgggatcggt aaagggacag cgctgactga aatccctggt 19620 aaacttgcag acaacttaca aggccaattg ataaaattgg ttgattgggt aacgggcgga 19680 atatcaggat tgattgatga tggcatggcg gctgcaaata aagtcgttga agacatgaag 19740 aaaggatttg ctgaaaatgt gaagaaacct ttcttcaaca tgttgaatgc tatcaccaat 19800 gcgatgtttg atatcgtgga taagtttgtc agcattatcc ccgatgcgtt gggtggtgaa 19860 gcagccagga ataagatggc ggaagcaaga cagtctatgc tgataagcca agacgataag 19920 gctcctgaga atgcctctgt accaccgaac agtcaatcgc cagcacaacc taatgcagat 19980 atcagcacgt taactccaat gccttctggg gtttcttcgg atgctgtgaa cgtaacagat 20040 cgcacttctc aattgaaaga tgcatatgct gggatcgggg gaggtactct gggtggggca 20100 tatccggttc aggggagagc ggctaacaac attgaggaag ttaaatccgc ctatgctaac 20160 ccgccagcca gtgttgtggt tccagtacaa caaaatgtgg acaactcgaa gaaagtcagt 20220 acgacgaaca acttcaacag ttcacaactg gagccgtcca accgtactga cgcaggtcgt 20280 attctttggg attggtaatc aaattccgtg ggcaaggatt agctcacgga gttttccttt 20340 tgtgtattct gtgttttcat caggaacaac tgaattggtt ttctttaata aaaaggactc 20400 ggagttccaa tagatgtcat ccttgagtat tgtatcatat aaatggatga accccactac 20460 tttattcaat ccaactagaa accaaattgg atagcgttta acaataatat ctgtcagtaa 20520 aggtggatgc ccattaccat ttcctttgat atattggata aaattcacgc ctctttcttt 20580 tatctcaggg atcatatatc tctcaaaatg ttcaagaaaa ttatatgaga agttgtcata 20640 caggcggcga tattcattat aattttcttg ggcctgtctt gtaagtaatg ttgtcaccca 20700 cgtctttggt gatttaacaa agttggcaat aatataattt tccaccactt caccttggga 20760 agattcgaac cgacgagcaa gtttagcaaa ttgtttggcc acgccctgtt tagaatagaa 20820 cgtttcaaac ttgtaattgt tcatcggccc atacaggcca taatcaaagt cttttgaggt 20880 gaaatgcaat ttgatcgcca tatagatgca ataaacgttg aatgcccttt catattgcat 20940 tttctcccac tcagttatca tggcgtttct ccctgctttt ctgtttctgt aatctgcggc 21000 gttcagaaca gaactgattg aactccgtca ccaatccttt ctcctttata aagagaatgg 21060 cgtttcgaaa agcaattcca atcttggcat atgacggcgg attcttacca accacgtgat 21120 ctctcctctg tgcgaacgaa acgttgaaac tcttctgttt ttccttggcg atgaataaac 21180 accaacgcca aaataaaacg acggaatgat tttgggataa gacgatagcc gttggtccaa 21240 ttataaacga catcagaaca attcatcatc ttcatcatct gtaattcaga aactcccaat 21300 tccctcataa tgtttatgag attaagagaa tcattgtctt tccttggttt cttatcaata 21360 agtttcataa taacacctgg taatgatttc ttggaattat actgctactg tctttattga 21420 atggggttcc gaagaacccc aattttcatg ccgcttccaa caacaccaaa atattttcga 21480 tatatgcttt ctggatagca tagacttcag ccagtgtatt agcgactttc ttgtctgtgc 21540 gtacttcaac gagacgtgga aggaatagag acttcatggc gtcatcggtt ttatcctgta 21600 cgccattaga gagcacggcg gcaatcttac caatgaagtc ctcttggttt tcccacattc 21660 gtagtctcaa ctcatccgag atccccgata cgccaacaac taagaggcca tcagaggtct 21720 tgcagaggag agatccaaat gtcttggcgt gcttcccttt cttatcggcc tcgttgaagc 21780 caacgatttc aaggtcacat tctacttcca tttttagctt taacccttca gatgatgttc 21840 catcttccca aggcatatct gcggccttac aaatcgtgcc ttcttcccga cgagccaaag 21900 catctttgaa gtgttcgaca gcttcttcaa atgaatgaac gacacgggtc tcctgaacct 21960 gaaccaggcc gtcatcccct tcgaacaact gttgtatgat atcaaaacgg cgctcatatg 22020 gggtgtccac acgctgagca ttgaaccaat tatcatacgg cacaacgtcc catacccgat 22080 agatcacctt gtaacgatct tccaggggtt cacccgtttg gataacactg ttgagcttac 22140 cattgccgat agcccgaggc aacactgtat tcgttttcag atcaatgacg agcagttcac 22200 catggaagac gctttcacca atccccgcat catagatcag gtctttgaaa accaatgaca 22260 ggttatcaac ggaaccaccc gcaataagag aaccggaacg agaacgaatc tctgggtctc 22320 ttccataacg acagatgatg ttggcgaaca tgccatctga cttcagctgg ctgaagacgc 22380 cgcgcttgaa gtccatcttc ttcagcaagt caatcgtcat gttatcataa cggtgatatg 22440 gaaggatatt aatcagacgc cctgtaccac ctgctgcgtt gaatgctgcg tttatacctt 22500 tctcggcaat tcccgctttg atgtctctgt cgagtataat ttgtatcagg gtatggtaat 22560 ccggatggat gttggtcgcg gccttcgcaa gttcttgatc tgccttcatc ccaccgatct 22620 tgcgttcggc catcatatca agaacgtcat aaacctgatc ccagctaccg acaacgccgc 22680 gcgagagcat gcgagggaat gcgtttagat tgaattgagt gcggtaataa gaacgcatcg 22740 gatcgtagac gtattgaagg aaatcaacca attctgggtt gtttctgaac gcctcggtca 22800 gcacagcttt cttggcgttg gtgcctttgg tatcgcgaag attttgaatt atttctaaaa 22860 gaggaagcat catgtgtctc cagggttatt cgtcatgcta ttataaccct agagacttca 22920 atagatttat ttgctgcgtc tttttctggc cttgtcaaca atctgaagaa catccactcc 22980 atatttgcgc attcttctat tattgatcca ttcggcccaa accggttgaa aaagaataat 23040 caagatcccg aaaaataata ttgcagacca aatataaaat gaaatatctt tcatatgtct 23100 tccttccaaa caaatccata cttggaaaga taatctggtt tcgttccatt acgagttcga 23160 gcacgatcca cgatagattc tacagtttct accttgtgaa tagggacatt tccattgttc 23220 atatactctt taaacaacct gtgaagatat atcaaaaatt gtttatcgta agtgtcgttg 23280 taattccaaa accatacagc agcctgatat ccatctttac atgctatttt caaataaaaa 23340 caatttgatt ttgatacaca cgattctatg aacggccaac ccaaacctcc catgaaatat 23400 tgaaaatatt cttcaggagt agtgtctggg tctttgtggt ctaagttgaa atcatctatg 23460 ctagtaacca aacttttgga cacacgacta ctcagaataa gttttatgtc tttaacattt 23520 ttcgtggtat tttctggttg taaatctgag gagacggcct caacaacccg ttttcccaaa 23580 gattttttga ttcccataac gagaatacag accccaacca tactaagaac agcaatcaaa 23640 atatctgttg agtcaataat gaccataaat cccccaaatg aaggggcata tgccccttct 23700 atattatttt gataaacttg ccagataatt gtccgcttct gttgctgaag ggctattggt 23760 agaataattg gaatcagcga tttcagcttc ccgcaggata gcatcaacat ctacattaat 23820 cattccagcc gcgtaatcga tgtcttccgg taaagttaac ccaagatcat ttgattcttt 23880 ctgaattcgg accaattcga gattagactt aacagcgtcc agtttgtcac ctaattcaac 23940 aattgccgaa ttcaatttca cgctgccaga ttcgatctct ttgactttat ccagcagagc 24000 ttcaccaata cgacgacggt ggagtatgat caaggcttca gcgcgggtag gagttactcc 24060 gcgagcgatc gcatctttca aaatggtttc tcgcttgacg gcttcagcca gattttcatc 24120 agcggtcttc ttcatcttaa cgccatggtg gacattggtt acacgggctt cttctaaacg 24180 ccggatttca tcagatagtt tccgtgcagc cagattcaaa cgcttctcag tatctgtgag 24240 tttatccaaa cctgcagtta aattggcctc gacagtgctg aacaggcggt ttaaaaaggt 24300 tttcagtgac attaatatat tcctcaatta tttcttaggt ggtgtgacag aggtgaagga 24360 ctccttccaa ctcttgaatt tttcaatcag ggattctttc cccatctcgc cgttggaaac 24420 atcatggata taagcaaatg cgtcataccc atatcctggt aaagcagaac agattcgaag 24480 gtgaaccaaa gattctccca cagaaaccaa ataatgatcg cgacgatcat tcagagcata 24540 atgattgtcg tgaaacttgt cgatgatggt gcagttttta ggctcaacat caatcgctaa 24600 tccattggcc tcagagccgc cgcgcccaag cgtacaacct gggaataatg tttctacgag 24660 tgtggacatt gtttaattcc ttctgtttaa ttcccatgta ttatatgggt aaacgtttat 24720 tgaattattt gttgtgatag ccaagagcct tgcggacttt ttcacggtca tctgtatcga 24780 cctgaattgc tttacgatta atccgacgcc tgtggtgtcg ggtgagcgct ttatacacgg 24840 ccttggcctc atggtatggc agacaatcgt aacaaaaacc gatatcgact ctataccctg 24900 cgttgctatt gactgtatat gcacataccc ttacgccgtt atagatgaca gcatctatac 24960 cgacaaagcg ttcaccattc cattcaacgt catcagcgtc gatagcatca ataagacaac 25020 gaatttcgac gcttaggggt ttacccaaca accagttaaa atatttgcgc atgtcattta 25080 ctcatcagtg aaagaagatt gactttatct gaacgtgcgt ttggtgagta atgcacgtcc 25140 tgagagtgcc tcttacagca cggacaatcc ttggtggcga ttacacaggg agctttatcc 25200 acggcgtatc cggcttcttc ggcttccttc acggtgttaa atggcaagta tgcacttgtg 25260 ccttgccctc cgcatgaaca ttccattaga aatcctcctt ggtaatgaag agcaaatcag 25320 atttcagatt ttggcgcttg acacggcgga catgtcgatg ctccttttta ataccgtctg 25380 aacgttttga tttagagcgg cgatttttgt atgtgtccgc tgggtacttg tcatggcctg 25440 gacaacaaga tccagggtag taaacatcca agatttcccg tttcattaac gtttcctctt 25500 aaatgggatg atcagggcta tgattaacag catagctgtg atcactccgc atgcgataag 25560 accgaatgca aatgctttca aaacaaattg taaaagaatc ataatttcct cagttttgcc 25620 cttgtgatct gagtttgttt aatacctttg aattcggtca attctttgac gcgaccacga 25680 atgatcatat cgccttctaa aaactcggtt tccatatagg aagtcttcca tgtaatggta 25740 ttgccttcct tggttttgaa agtatacaga tacgtgtcac cataatcaga cgaatacagg 25800 aaaatccttg cttcaaattt gacttgcact tctaacattt caccgacttc accaacccaa 25860 tttgatacag tgcgcgtttg gcgcggggtg tggatataat cataatactt tgctgctccc 25920 caacgaactg tcgtggagtc cttaacgagg tgatatcccg gttcacacat acgtttcagc 25980 cggacgttga aatcgttatt ttcagacaac gcggcgatga aaagcatcat atggtacatt 26040 tctgattgag catcttcacg ggctttaaca gccttgttat agaatatctc aatgtcagaa 26100 cctttctccg gacgagtacc gctagagata tgaccaagaa ctcgaccaaa atcatcactt 26160 ttaatgctca ggccggacag caaaacctga aagcatttac acaaatatcc ttctgtgtca 26220 acataatctg gttcattaac ccgataaatt ccttctgggt catcttcatc gggggtaaac 26280 atttcgtgaa tagacatgta ataagacata accgcatcaa gggatttctg atgcgggaca 26340 taatgatgca tgcagctgct acccacgagc atctgtgcgc cagattgttc gttacgaaca 26400 acatatgtgt tatgacgacg cacagatttg ttgcaatgct cgcaccaaga tacgttttca 26460 gcttcgaatc tttgaacgaa atttgggtgg atgtcatctg acagtttatt cagaatgact 26520 tttggatact ggtggttgaa ttgtccaatg atactccacc caccataaga aacggggcgg 26580 tctatgcctt caccagttag agtacaatct tgccaccaac gataaaattt ttcgccagtg 26640 atagaatcgc gatgttgtgt tttgtatggt tcactgaact caacaagagg aaactcgagt 26700 ttcaggcggt ttgccgttct ttcaagtttg gcaagacgtt ccttgacacg accaatgtta 26760 tcaattggga tgctgaaggt cttggctttc atttttgcct ctcatgatgt agtgaaactt 26820 ttcaatgtag gttaaatgat agccgcaagt tttattgaag taaagtttta ttgaattaaa 26880 gcccaacaaa tgttgggctt ttaccgatat tattcagcag tgcgatcagg tgctgcgtta 26940 ggatacagtg actcataaag atcctggtat ttggcgctgg tctcgatggt cttggtataa 27000 gttccaccag cgcgatcggt aacgactttg cgcagatcaa cggctttgat gcctgtttct 27060 tttgccaatt cagccagggc ttcggtaaca aaggtctgtt cagacttgat acggatctgg 27120 gcggcacgac aattttctaa agtctgcatc atcttttgac gcagttttgg atcagaaggg 27180 agttgataaa aaccaatttg ttcaactgac ataatatatc ctcattaatg acgagaaccg 27240 agtggaccga tactggttcc caaacggcgc aggaagaaat aaacgatact gtgaaaacca 27300 aacttaggaa taatatcaac gccttcaaca ttgtaatatt cctgagtgtt ggtctgtact 27360 ggcaatggaa aagacggaag atcaagctga accaattcac ctggttcgca atgtatcttg 27420 acattcttac cccaatgccg acgattctta taaaattcta gagtctgctc tgtagtgagt 27480 ttgagactgg tttctccaga ctggcacacc tgttgtgccg cccgaatcag gtcagctata 27540 aatgcaacat ccgacatgat gtgctcctgg gttaatattc agatcataga gattataccc 27600 tatgatcacc attattgaag ttaaccgaaa ttccaattgt tcacggtctc ggctttcttg 27660 acatcattta cgtcgcctgt tttgtttaag tcatgtttga tatgaacatt ctcaacataa 27720 cgggcttctt cttctgtcag gtctcgcttg acttcattcc aatccaagtc aaacaatatc 27780 tgtttatctt gatccatacc gaacaagaac gatttgagtt tctgtttatt ggcataacgg 27840 tttttcaaga tagacgctcg ggctttctta acagccgcca gttcatcagg ggcatagaac 27900 gccatgatga agtctgcaac cttcggaata ccgatagcat ctgccaggtc gctaatatca 27960 ccatcagtcg ccgattgttt ttcacggtta aattgcatac ccgtccatac agggcaatca 28020 aattcaaatc caagcgcacg gaattcacgc gccaccgaag tataatacac gttggtgttc 28080 tgcattaaat gagcaggaag acgagaagac gctgattcac ccaagtagtc tataataatg 28140 acgtccggcg taattcccgt ggatgtcgcg taatcaagaa tatcgcggcg atacagtcct 28200 gtatgcccag cgcctgaagg atattccttg ataacaatat cacccttcat ggaaccgtct 28260 tgacgagttc gcaacttttg tatcgtagcg acatattcat gtcgtgagag cttctctaag 28320 gactcgaagt ccctgcgcat catacgggca tcaaggcggt gacgccagac gttctcagcc 28380 acttctaggg tgaatacgaa tacgttcaac ccttgctcgg agtaaccagc agccaaatca 28440 atcagagttg ttgtcttacc cgcattaatt gcacccgtca cgatgttcag cgttttctta 28500 ccaacaccac cacgagtcgc tttgttgaat atctctacag cgaaaggaat cttcgcttca 28560 ttagagttca tgtggtcgta ttgttgttca gccatttccc aatagatatg gccaagataa 28620 gaatcaaaac ttatcgccaa cgcctcttgt aggagagttg gaatcgtgtt catctcatct 28680 ttacgtttct catcaccata gatgttgacg gcgtgtttga tcgcattatg aacagctttc 28740 tgccgcgccc aactttctgt ttcttttaca agccattcct gatggaatgt gttgtcattg 28800 atattctcaa gagcagaaat agcttgttca aatacgtgtt cgttgagcga agtcttttcc 28860 agcataatag acaacgcttc aaccgaagga cgagcattat attcgcaagt gtaatggtca 28920 atgagaccga atataatttt ctcgccttcg ttatcgaaat aatcggcttt caaatacggc 28980 tggatctttc tttgatattc ttcgttatag attaattggg aaagcacgac agattcgagt 29040 aacattggca actaccccac caaaattttg ttgtaatcct gagcattttg ctgtatcaga 29100 tcaactaaga tatccccaga caccacagtg aacaagtcat tttctttcaa attaacaaat 29160 aacaaacgcc atggtttctt caatatatct gttgtaaagg ataaccgagg ctctccatta 29220 tctaaatgga cacccacttt ccctatacga aattgaacgc cacggaattt gccttccgtt 29280 atttcgatta ttgctaactg atcagaacca gggtcgatga ttttgtaatt aacggggagt 29340 ctcctccccc tgcaatatta ctcggttgtt ttgatgacat tatcgaggcg ctccagcata 29400 tctgcaggca taaccgaact ctgagagata ccgaacatgt tgttcacatc gtcaacaaag 29460 tctgggtttt ccagcagcgg ataccagaag tcatctccca gctctgcctt acgatatttc 29520 ttttcttttt ctggatcaaa cccgcctttg gcagtgcgtt gataccaaga accactcacc 29580 aaatccacat accccagcat gcgcgcaatt tctaacatac cggaccaacg gtcaataccg 29640 ccttcataca acacagtgac agggaacttg gctttttcac ggacaaagcg gcctttcata 29700 atgttgactg taaactgcca tcccaaaagg tctttgtctt cttttacttg agcacgcgtg 29760 atgaaccaca attggttaga agacaggaac ccctgtttac cgcctttgat gttcggctcg 29820 gcgtattggt tcccgatttc atcatagtac gagttgatcc ataccaaaac gaatttcttt 29880 tcagtgacca acggggtgat aacacgccaa aaactattga gagcgcgagc gcgggtcata 29940 tcttgtgtgt ctttgcccgc tatggcatca tcaacttctt tagtagacgg caactggctg 30000 attgagtcaa tgaatacgat gatcttgtca cctttctgtg catcgttcag aagctgtgtc 30060 agcttgatct tcgtcttttc aacgttttca attggcagat acaagacacg gtccatgtca 30120 atacccatag atgtccagta gttttcattc gcaccgcctt ctgaatccgc gaagatacaa 30180 attgcatcag gaaacttatc catgtaagcc ttaacatcca ccagcccaaa catggttttg 30240 aatgtacgag aatcccccac caactgtttg atgcctgata tcagaccacc atcaatacga 30300 ccggaccagg ccaaattcag aataggaata cccgtactgc aaataatgtc aggcttcagc 30360 gcatcggtct ttgacagcac ttcggcattc gggtccagtt tctttgctgt cttgagcatg 30420 cgagccatca atgaatcggc catttcgttt cctcttgctt gttgatcgta attaataaat 30480 cggtgcccaa tactttcttg gacaatatat tgattgcttc gtgaatcgcc attattgacg 30540 ggagtttttc atcgttaatt tcggaacccc cgcgttctgt taaatacata ttacgcagac 30600 gattgtgctg tgccctgttg acacaagaaa cattcaatgc gatattcagg atatacatca 30660 tttgttcagt tgtaacatcc tttggaatag catgaacata atatatcgca tcttcaaaat 30720 agatatgctg taatgactct ggaatttctt ccccgccaaa agcaaaatct tcaatgcgtt 30780 taaaaagtgt ttccggctct ttggttgtaa tatgttgtgt tacagtagcc gcaccatctg 30840 gctctttctt gaaattggtc gcaataacga catgaccgcc tggtttaata aactcagcga 30900 agttctctgc catgtacggg gcatgttccg cataatatga tacgacgact gtaaacatta 30960 gaactccaga gtcagagggg tttcggcaga cttgtcatag ttcgcaccgc cagcagcacg 31020 tagacgattg cgatcgttct tgcgtttgtg tgccagcata taggtttcgg tgtccagatc 31080 caaataacca caagcctttg ataaaaaccg cacaaaacgg ataacatctg gttgttccat 31140 aaatgacgta aaacattctg tgaccgattc cagattggcc gatttgtcta tcactcgtcc 31200 gtccttgaag aaaaggtcaa tctgcatttc aactgggaaa gcagaaccaa atccagataa 31260 aatggaagac aacataaaat gtaccacgtc caccaattcg tagacagctg cttctcggtc 31320 atattgtatc ccaccgccat agattttcca gtcctgggtt gtttcgtcaa gaaactctgc 31380 ccactcacga tagatggagt tcaccaccgc cacatgagtc caatgtttac gccactcttc 31440 cccaaaatag gccacattgg tggccttttg aagttcgagc agacttttga tatgctctgc 31500 tgtgatcatt tccgttccct ataaaatttg acgaatggtt gccaaccttc aaatgggtta 31560 acaaattcat aatcaacttt catctcatca atgaaagcct ctatgtcgtc ctctatgata 31620 ccgccgcgat ctgcctttga aatgcgggtg atgggacatt tagtgctcag cgcccattca 31680 tattcttgag gcgtccgtag atcactcaca atataatgaa tgttaggatt ctgttcaact 31740 aatgggagtt ggtaacgctt aaagaaagac aaaaacagat ccggttggac ataacgaagc 31800 cccgtatcgc tgccgagatg aagccagatc tgtcgtggag ttaagccctt ggggttatca 31860 aggtgcacgt aaggaacgtc cttcacggca tcctctacct cctcaggcag ccacgggtag 31920 atgtagttgg caacacggcg cagctcatcc gagaaagaca ggcgttgaat gtccttgtct 31980 ccctgtagat ggtggtagct gatcagggac tccaaacaga agtccttgcc ggagcgctta 32040 cgccccgtaa agaattcaag gtttggatac atcataacgc accttccagg aactttggat 32100 caacgatctt gcggtcaacc ggagagtgag tgagtgcaat gttcagacca tgatcctgaa 32160 tcaggttcat gttgatcagc ttatcgttca gcttgcagta caggcagtaa gccatctgca 32220 cgatcaggcc acgatcagcg tcgtattcct tcaggtgagc aacgacagtc tcccacgggc 32280 tgccaatatc gcagtgatga agcacaccag tgaacagatt gcggatatgg ttctggttgg 32340 tcacgttcgt gaagtggatc atcgagttga tgaacccagc ttctactttg gtgtccttcg 32400 tgatcttacc cagctgcttc tggctgactt cattgttgta gtaatgaaga ttgttagaga 32460 acagcttgta ctggccgacg tctacatcca gcacctgcgc gatcacttcc tgaaggatag 32520 agaactcaat gaagttgatt gaactcatac cccacaggac atcttgtgag cggttgatga 32580 ccgtcaggtt cagacgacct tcaacgacag caaataacag agccaggtta cacaccatgt 32640 ctttggtctt cgcttcgttt gagccgttgt gcttggccag accaacatca gagtccagag 32700 acggatcata gatggtgaga tacgcctgac gggtgttgat gtttttgcgg agacggttga 32760 tgacgctctg taactgacca tgggcgtaca ggcgcggccc ataagcggct cgccatgtta 32820 ggccatcgtc ggagaagttg gcagcgcggg gcaggacacg tgacaggaac ttcaggtcat 32880 tgcgcccagc cagcacccag aaagtctcac cgatagctgc gatggccgat gagttgcgac 32940 cttcaacgga taaccagcgg tcacggatat tactgacggt gatagtcaca ccatcaagaa 33000 agcgggtgcc gtcagtgttg atctccgcgt tgccaggatc agattcaatc ccgtattcac 33060 ggatagccaa gacagcctgt tttagcatgt cgttgttatt gatagcttta atttccatta 33120 gtcaatgctc ccaaagtcac ggaggaggaa cgccattaca gcttggtcta cagttagacc 33180 gtgagacttc atcatacccg cacacacggt agggaacaac tctttatgcc gcccccgatg 33240 gttgtgaacg cgctcccact tctcgaccac cagactttca ttgaagtctg cgccaccgtt 33300 acgcgatttg acacgggcaa tacaggtttc aagaggggta tccataaaga ggacgaccaa 33360 ttcacgtggt gggcgtgtca ggcggggaat ccaagaactc aataatgtag acggaatgat 33420 gccttcgaaa atcacatcat atttcaggta ttctggttgg tcagcaatag acaacgcgaa 33480 caacatctgc tcagtgtccg tcagagaatc aacccctttg gacttagact tgtcatattt 33540 accgacacag acaatattgt aagatggaca aaccgtgagc atgatcttac tgttatgggt 33600 tacgacatac gcctgaggat cattctccgc caaataagaa ggcacagtag acttaccact 33660 accattggag cctttaatgt aatacaactc tcctcgtgcc gaatattccc cttctacagc 33720 aggtggtttg acaaacaaat gcacagggcg cttcaacagc cctttgagcg aataagacat 33780 gacatgctcc aataaacaaa aggagctgct attatagcag ccccttcatc tattgaatgc 33840 ttctgaatta aattacgcag cagctttcgc ttcggccaac gcctgtggca accattcatt 33900 gatcgctttc accagagatt cggcatcagt ttctttgatt ttctggcgtt tggtgaatga 33960 tttaccattc acatacagac tgaaccccca gccgccggaa acgattggcg ccagatcaac 34020 ataagtattg gtgcgggcgt gtggattggc ttcatctgcc agttcggtaa cagggaactg 34080 gaaccagcgc atatccggat tcacatagct caaataaacc ccaggcacaa cccctgattc 34140 aaccgcagcc aggataggac cataattgga tgcgcgagcc gcttcaacca tttcttcacg 34200 cttgttatga cgacgcttgc gttcttcggt agaagatgca gggcgcattt cagaagattt 34260 cttggccaga accgccttcg cgttcgctaa agcctgatca tccttcggat tttcaacgtc 34320 ggcgattgct tcagcaacgg ttgtgcccag catacgacgg cgaacttctt cagcacgggc 34380 ttgcgcttct tcgtcaagaa cttcttcgcc ttcaactacc agggaaatgg aaccgtcttt 34440 gttgacttca agagaaccgt cttcgacggt ctgggaattt tgatcaccga caggttgccc 34500 aaccgtttct tcggcgtcaa tcaccggatt tgattcaccg tcgccctgtt taacccccgc 34560 atcttcggtc ggtttaactt tttcggcttc agcgcggtca agagcttcga gagtttcttc 34620 tttctcttcc tggctcagac cttcaatgag ttcaaagcca ttggctgact ggaggacgcc 34680 ttccatcata cggcgtaacg tgacgttgcc gatgataagg tctgcacctt tgatttctgc 34740 ttgaagatca gcagcggttt taccatcaat ttcaaatttc aggccggact cgatatgaag 34800 aatataggac ataataaaaa cccttttgtg tagtaacctt ctttggcagt ttaatgttca 34860 actgtgcgtc tggaacatta atatactgcc tttttagaag atgtaaacca ctttttattg 34920 aaaagttggt taacacttct gtgttagaca acggaacgct gtatcagcgc ggactggcgt 34980 gaatattaac tttgtatatc aatattgaaa actgtttcag gtggccacat ggcagacaac 35040 tcgatctgtg tgaacttcgg ttgaacatac tgatctaaca cttcatccca gagagcatgt 35100 tctatgttgg caatcaacaa ttcgtcgtcc actatttcga cggaatgaac cactatccgg 35160 tggttataag tcaaagcatc gctcacatga tcattttctg ctctcaggtg ctgcattatg 35220 aaatattcga ttacagattc cagtaccgtg ttcaggcgaa catatttctt catacagccc 35280 cctgcttgtg ctacagatag aaattaggga tttcgccgga ttcacaacca aacccgttaa 35340 aattctgctc aacatgtaag cgaattttgt tcaccactac ctgacgatgc tcttcttcca 35400 tacaacgttc aatcaaagaa tacgctgtat atgacagact gttgaacaat ctggaaataa 35460 caaggcaatt ctcttcattg taaacgactt cagtatggat tgcgaaagcg tggtcttcgt 35520 cggtaagaat tttacagcct ttgaccacaa atggtttttc aaagaaatca cgagctgaat 35580 cagtgccaga ttccggcatt aaacggaaat cgccttcttc gccgaaaact gctttcagat 35640 tttctttact gaattccgct tccatctgta tacgtttgtc ggcaagatat ttcgccgcaa 35700 agtagaattt acccactgca tcattagcag cgcggcggtt cgtagcggct tgggtataac 35760 cagaaacgaa gtcttcaatg aattccaatg cttctggttt gccaaaacga atttcgtcgc 35820 ccagatccaa gctggcttcg gaatcaagtt caatacccat aaccttaaga agatccgttt 35880 cattcagcct gtgcggatta aacaattgtt ccttggaata tcccaactgg ctaccgagtt 35940 catatccggt tttaccaccc gaatctttat gggtgcgatc atagcgaacg caattagaac 36000 tgaattcaat accaaaaata cgatgtagct gtgacatatc ataacctcat gtttatagaa 36060 agccgttcgc gaattatcac gtagaacggc ttttagaact aaccattttt gtgtttacga 36120 cgtgcgtcct tccaaacaga catctgactc tgtttctgga atcgagcagt acgcataaac 36180 aaaacgacct cccaatattg cggttcaatt tcataaagtt gtgaacgaaa ttgatcagcg 36240 cggtacagtt tcacacaatg gttgtacaga gggtgattgg cgaaccgttt cagggcatcc 36300 caggtaagtc tcaaacgtgt tttagaacga tatgcccgtt catttctcaa tttaatgaga 36360 tcttcaaata ccaacaatct gagtttaggc ggtaaataat ggaggtttag gccataaaga 36420 taggttacac cacgttcacc gaatttcacc ccgtccccct tcacaaaatt gaagaagaac 36480 accagaggat acatatccca atacgggagt tcatctttag tcagcgcatc atatttgaaa 36540 taatacatgc gaccaacaat ataacgcaca ccctgaacag gacgtttatt ttcagcgaat 36600 gctttcatca tgtgattcgg agataagtta gcatctttcg atacgcgctc cataaaccac 36660 acatgagaac gacggatatt acgcttcgct tccggcccaa aatgttgacg atatttgcgg 36720 atgtaacgct tgaccagttc tggggcgtcc atctcggcgg gaagcaacaa cgggtcttct 36780 tcacccatag cgttcttagc catttgtcaa ctccttataa atatcaacag atatattatt 36840 taaatggagt cctcatcgtg gaagactatc gcaattttct aacgcaactg cttcaacggg 36900 gtatttcccg caagaacaga tttcgtgtta caattccgtt gccgcctgga atatttgatt 36960 ccaatgcgac actagcaaat gatgggaacg catatccttc atcttcattc ggcgatttat 37020 tcaaacaaag cgcccgtatt gtaaacgcat tctttggagg gacaaaccaa acatctcgtt 37080 ccctgcaaat gatgtgtatg gtcgcatctt tacctggtac agggattgac actactccca 37140 tgaccaacaa cggcaaccac attaaaatgc cgaacaacaa gacgaacatt gatctggagt 37200 tgtcgttcct cctcgccaac gattattatg aaaagtcggt catggacaaa tggaagaatc 37260 tgatattcga cccatacaca accaagatgg gttattatga agatttcgtg accgatattt 37320 gtatagagca aatggataca gaagatcagg ttgttcatcg cgtttatgtg actgaggctc 37380 accccatcaa cttcagttct atagacctgg ataaaagcgc cgccgatcaa tttaatcagt 37440 acaacatttc cttttcttat aacaaagtat tatcggagac tgaatatgaa acgcgcagcc 37500 tcgccagcga ttttcttcct ttgggtatta ctgatgctct tgcttccgga gactgggaaa 37560 ccgctgcgtc aaaagccgga cagctgtata aaaagatcaa agaaggaaac ttcacaggtg 37620 aagccctgct ggcttataag caactcgatc agcttgtaaa caatctggct ggtatcagct 37680 tggctgattt cgaaaggatc tctatcggca tccagaggga tatcttaggc aatgataacc 37740 tgacggcgtc tgagaagagt agtctgttgg gattgttaca ggatgttgtc aaaaactaaa 37800 aagcccccga aggggcttta gcgaaattag tctttcttca ggaactgctc gaactcatca 37860 atggaagccg tctgtttcgc atcggcacca ccattattgg ctggaacaga ttgctgtgca 37920 ttagaaggct gagattgttg ttggttcaga ctttcctgcg ctgttgggcg ctgtggttcc 37980 tgagactggg taggcgcatg tgccatagta gaagcaccac cttcaaccag aggctgatta 38040 tcagggatgg ccagaacttt gcgcaaacgt ttttccagat cttcgtacga tttgaagttg 38100 gccggattaa agaactcaaa cagactgtgt tctttttccc agatctcttc aatgtattcg 38160 tctgtcccca aaggtgccgg agtatcccac ttcacattgg tgaagttggc caccagacct 38220 ttccagttgc cgaactcttt ctcttcgcca aagaggttca gaatcaggtt cgcgccttcc 38280 cacatatcga acgggtcgaa tttagggtca gttgagaact taggattctg agccgaatcc 38340 aggattttct tgacggcatt accgaactca agcaagaaga ccttgccgtt gttttccgga 38400 ttgttgccat ctttgatcac caggatgttg gcgtagtatt tggtgtccgg cagacgtttt 38460 ttgagaactg ttttcagctt ttcatcattc gtttctttct gttgtgccca cagaggacgg 38520 tcatggtcac gaacaggatc atcgttaccg aaagtctgcg gagagttttc gatataccaa 38580 ccaccagcgc cctggaatgc gtgtttcatg atcatggcac acggagttaa cacagcatct 38640 tcagggatgg tgccttcttc tttagccttc atgtccacca aagggatcga caggaaacga 38700 atgatgtttt cagaagtacc cttgtcattc caggtccact tccagatgcg cgggtcacga 38760 ccgccaccaa cacgctggcc ttgctgagcg agtcgctgtt gcatagcttc ggcttgttgg 38820 ccacgagatt gtttaagacg atcaaataaa ttacccattt taatattcct ctataatccg 38880 ccccttcggg ctattctgta aatgtatttg tcaattattc cgacggtgta attatactgc 38940 gttttgctat tgagttaacc cgcaatcatt tgttttgctg ggtctatttc aataatgtcg 39000 tacacatctg agaaggtttt gtgtccttcc aagaatgtat ggtattcgat gacataggat 39060 ttaccttccg gcgtcgtgta acgtacacga tccatatcat cagcatgttc attgaggcta 39120 ccgtgccgcc agcggataga acctggcaga tactcttgcg ccttcaacat tttatagatt 39180 tgctctttgc tcatgttaca accttaaatg agttttttag atttcaattc acccttcaac 39240 aaccgagcat cagaacattc agctgttagc cttgacagaa gaggaggcgt gatcaatttt 39300 ttgacctttg cttcttcgat gtcatactct tcacaaacac tggccatcgt ttcaaggatt 39360 gattccttgc gttggcttgc tctcatcaac accaattcgg aaaaagaatc tggtgtgagc 39420 acttgtgcta tttgttgatc agacatcgat tgtattcccc ttccctgatt gcttcttaat 39480 atgacgcaaa acgtctttga agccatcagg cgcggactga ggaccacgaa caccagatac 39540 gatctttggt gctccaataa tcatttttat ttcaccacca cattcagaac atggctctaa 39600 ttcaggtgta tgacgttcag cacaagattt tcgagcacta aacgaatttc cacaacctgt 39660 acaggcataa tcataaaacg gcatgaatcg cctccaatac gtgtcgtaga aatataataa 39720 ctgctcccac cagcgtagaa aacaggacaa tcctgattgc tttgtcacgc agcaaaacat 39780 attcggccaa catatcagat tgatttgcag ctcttacatt gacgtcacta tgtggcgaaa 39840 ccgcatagaa agataccatg gcgcttaatg aatgaaggaa tgtcaagaat cccttaatcc 39900 aaacaaacgc cgtcatcaac agcaaggcga aaagcagtat atctgccagc agccagtagt 39960 taatcatttc ttacacctct attgaaatca ggataatttt ctatgaagta aggaccagaa 40020 accatatttg cgaacgaatc cacgaggtca tcgattggct ttggatcctt tacgtccaac 40080 atgtccatta taccgcgcat cttaacgttg aacagcttct caaagtgatc tatcatgacc 40140 aatttgtcgg catttccttt accacaaaaa tgtttcttaa caaaagacgg ggtaacaatc 40200 tgaaattcca tattgttccg gcgcatcgct tgtttcaata gagatgtgtt ctcggcggtt 40260 tggcatatgt tattggagtt ttttgaattc cccatagcat agccttctag ggtgatgaaa 40320 tccggcttct ccgtaagaag tacggcttca gcccatttgg aaatgttata aaaccgttct 40380 tcgggggatt catatttggg ttgacgtaaa ataagaatat tgtgtcgcac ttgacgacaa 40440 tgcttctcaa cggtatggtg tgcatagaaa tgaagatgat caaaatccag aggatctttg 40500 tcgtcccaga agcacatggc tggacagccg taagaatagt cgattccgca aaatttcata 40560 aaaaataccc ataacgaagt ttcattgtgt tatgggtatt tagaccggat tatctggtga 40620 cgattttgct ttccggtaaa atcaggcgag gtttggagtc catttcttct tgcatctgac 40680 gtatctgttg cagtaatgca gaagtgtcca catgacgttt gatccctcgc gcctcatcac 40740 catatgacac atggccgttg gcgtccacat aatgcgcggt gcaaaccatc aaaacataac 40800 ccaactcacc aacggcaacc gttaaatcaa ccacttcgga agccaaagat tctccgtcaa 40860 cactgagatt gggtgaataa tggattttac catcagccat aaattcgcta ttcagcataa 40920 tcatgccagc gatcgtttgt acaacggggt tcccctgatc atcagcaacg aaaccgtcga 40980 atgcgccttc aaaccctggc gcaatttctc ccttttcatt tgtgatcaca gcgcgaaggc 41040 gttgaaggat gacgtcttgt acctgctgaa tatcagcgcg ttctacgttt ggcattattg 41100 ttctccagtt cataatcccg ttctttaaca tattcataaa gacgggaagt aattcggtcg 41160 gcattgcctg tagtattctt cacaacccaa ccgctcgtaa ggacatccat tttatatcca 41220 caatcattat cttgaaaata acttttaatt gtttcaagac gacgacgttt atgaaaatac 41280 ggtattaatt caccgatgat gatacaatcc ggatagtgtt tttccagggt gttaatatct 41340 cgttgcaccc aaaccggaat aacatcatcc tcttcaattg ggctgtacgt tggatcaacg 41400 ataatcacat tgaatccata attcaataaa tctttaactc ccagccaccc gaatttcata 41460 tcggacacgg tcatggcgac attctttatc cccaatttat ttgcaaaatc tgtgagtaat 41520 acaaaaaagt ccgtgtttgc atccggataa ttaattgcga gttgctcccc cactttactg 41580 aaacagaacg cgtgcatttt cagtcctcgt tataaataca attacaatat accgtggaga 41640 tacattatga atttaccatc attgcccaaa actgagagaa cacataaaag tgatttctgg 41700 ccgactgtga tcaaataccg cgcctttaca gcagggcaac agaccatgtt acttcaggtt 41760 gctgatccga acactcctat gagtgagcgc gtggcaacat tggagcaact atttgacagt 41820 tgtgttgatg ctggcgttcc ctttagtaaa ctgccaatcg gtgttactga agaagtattt 41880 ttaaagatgc gctgtatatc tatcggcgag gtcatgaaga tacgttacaa atgtaacaat 41940 aaagttcaag ccgacacaaa tgaaggtgaa gaaccagttt ctggtgttaa agattgtggt 42000 caagagcttg tgttaccgat cccgctcaat caggtaaaat gcgtgtcccc agaaggcttc 42060 agggagacgt ttgatctacc aggtggttat catataaaga tgcgccagcc gtccttctcg 42120 gatgcctcag tgcttaatga agcatcctct gttgaacaaa tgattgccac ctttatcgat 42180 tgtctgtatg acgacgatgg tcaggtttgg aaggtggaaa atccggctga acctggtatc 42240 gatccagaag ttgctaaaga acgccaacgc attaaggatg aatttgtcaa atgggttggg 42300 gacaatattg aatctgagat tgttcaggac atttcgaatg atttctttaa aaagattccg 42360 cgtattcgtt acgcgacaaa aattaaatgc ccttcgtgtg ggaaagaaca cgaagtcaaa 42420 tttaacagtg tcactgagat tttcatttaa tttttgaaat tgatttactc tcctattttg 42480 tgatgtgtga cgaattaaag gcacacggct atagtatatt tgaaatcagt gaatcgatgc 42540 cgtggcatct tgatttgctt accgagacac tgaaaattag attgtctaag aaatcttcca 42600 accccacgta atgtggggtt ttctttgctt acctgtatta ccgtttaaga aaggattgtt 42660 taacccgaaa ttgctataac accgttgttg ctgaagtaag tgttgtgtaa atctgttttg 42720 aatttgtttt gaaacaaaaa taatgctttt ctacgcatgt tctgaggtgt acagtatttt 42780 cctcgccttt atgcctccat ggcattggaa tgggactgcc tgtcaaggcg gtgttacgag 42840 cttcagcgag taggaacgaa aagaataaag gttgaacgga agcagagctt cctataatat 42900 attattcgac agatttcaaa tccccgccat aaatatcaca tgattctaat tgactaatgg 42960 gtttcaatat gttagacaac ttgcgttggt tttacgggcg cgttgaagac gtgaatgatc 43020 ccgatcaaaa cgggcgcgtc gcagtacgca tctatggggt acacacggag gataccactc 43080 tactgcctac cgaattattg ccttggggta aaatgcttat gccagcatct aacgcctcct 43140 cggcaggttt aggctggtct ccgacgggta tcactgtcgg ctctgacgtt atggggtttg 43200 ctttggatga agcatatcag aacatccgta ttgcatgggt atggccagca gcaacaccaa 43260 cagatgggtc agatacaaac ccgttggcgc tgggtcaggt cgttcaatct atagaaaggc 43320 agaagtataa tgccgtcgag aatgttcctg ttaagattga ggatgaacca caaccggatc 43380 cacaaccacc agtagacgga tatgatcctg agaagtggat gaccgtggct cgtggggaat 43440 tgggcgtcaa agaatattct ggtaagttca ataacaaccc aaggatattg gaatatcata 43500 agacaacttc cctgggggcg tcagaagatg aagttagttg gtgtgcgtcg tttgtcggat 43560 gggttctgat acaggccgga tatacatcaa cacgttctgc tttggctcgt tcatatttac 43620 aatggggatc tcctctgtca gaaccacgtt acggcgctgt tgtagtgttc cggcgcggga 43680 acaacccgac attcggtcac gttgcattcg ttcagaaatt tgacgccaac tacgtttggt 43740 gtatcggggg aaaccaatcc gattcggtga aggtgagccg ttttagccgc tcatccgtgt 43800 tgggttatcg ttggccaggt ccagaaacta cagcttcagc agctccggca caacaaaacg 43860 gtaaatggtc tgaacctatt ccagatcgta ccccgaaagt ccaagaaaca ccgcctcctt 43920 ctggtcgtgt tcaggatatt gacaacacag gagaggtatc ggttccttcg gctggggggt 43980 ctcgttatcc atacaacaat gttatggctt ctcgcgctgg gcatattatg gaggtcgatg 44040 acactccagg cggggaacgt ttgcattgga tgcactcttc tggttcttac aagcaaatgc 44100 ttcctgacgg tgatgttgtt aataaatcag tcaaagatca ttatgacctg acgatgttcg 44160 acaaacgtta ttatgtgggg cgtgatcata acctgacaat tggtgggact gaagtacagc 44220 gcaagacagg agaagtttat cacttacact cttctaacta ttccaatgtg gtcgctggaa 44280 cagcgttgat gaaattttct caattggctg agatacaggc acagaacgtg ttgcgtctca 44340 tctgtgaaat gtttgaagtg tctaacactt tgaaggttcc taagatactg gcaactgaaa 44400 taatttgcga taaattatcg gtcgcacaga ctattgaagg caacatcaaa tatgctgaag 44460 gcgctggtcg cgccgcctca cgtgcggggg caactcctgt aacaactaca ggcccaggtc 44520 caattgatat aaaaccggag ttagaggata acggtggcaa ttttggtggt aaaggcgcat 44580 gattacactg gtgagggcag ataatgccct ctcgtgctgg agaggcaata tccaaagggg 44640 tttaacatga aagagtacaa ggacattgac ctgaagtttg gcatgcatcc ggtcaccaaa 44700 gatgtcacta agaaaacagg catttatgct gtactacaat ctgtgcgaaa tatcgtgatg 44760 tctacagtag gtgattggcc gacgtatccg agtattgggg cggggttgta taccatgctg 44820 ggagaaaaca caaatcccac gatacaggtc gacgtgaaga acaaagttga agatgccatt 44880 gctctttttg agccaagagc tgaattgcaa tctgttgatg tatcattgtc tgacgattat 44940 cattctctgg gcgtaaccat cacgttctat gtggtcaaca acccagagcc gataacagac 45000 accatatggt taaaacgcac aaactgatta aggtgcgttg gtattgcagc ggttggtaat 45060 tatttcaaaa tgcgtcagta aacggtacag taatttccca cctattctat gggctatggt 45120 ggttggcttt aggttaacca ccacaccatc tagtctcccc gtcaacacaa atgttaaacg 45180 aatgcgaagg atatcactgc cttcagaacg cattatttga cagtcatggc tgtaccctat 45240 ttctttccct ttgaggacaa gaggaacatg tgcgctttcc tttaacaggg tatctaaatt 45300 ttcaaataaa ggttcttctt tgttattgac ggaatacacc gtctctaata tcgggaattt 45360 atacatatca tggcaccaac gtaatcacaa tcatgttgag taccgtatca accgcgacac 45420 cagaatcctc ttcatgtatg gttgaggcgc gcaagtggat atctgaaata taattgtcta 45480 tatgcatcga cgtcaaataa ggacggtgtt gatacacagg acggttgacc tgaacatatt 45540 cacgcagaat gctgaatgaa aagtcttcac attgagtggt gtcaatgcgc aaaaatcttt 45600 gagcatggca ggtctttaac tcggtcactt tccccaaata atggaggtct ccggatgaac 45660 cgatacggaa catcacgtct acttcagatt tgaaaatttc gcgttcaata agggtcgctg 45720 gtgcccaaca aacttcttcc ttgtcttcag caaacaacgt atcgatcact tctggtaatt 45780 ggatataacc aaagttgtgg cgggggttgg tgagtaattt gttggacata ttatgctcct 45840 attacgtgct gtttggcttg ttcataggct gtgcggagtt caagataaga atctgccaac 45900 aacggtgatt tgtcgttttt ccgattcatg attatttggt ggttaacgac agcacggcgt 45960 aatctgagtt ctgccaccca gaatgctttt tgtttggcgt gtcctggacg ggcgcgtagg 46020 tcgtgataat gcatagaagc atgatatatt tcagagttgg tcatgatata gttcctgcta 46080 ttcaatttgt ggcgtttgcc aatgaattac tgggaagtat aggcggaaag gtttcaaaag 46140 taaagcccct cattgagggg ctttgaaaga tcagcgtttc aaacttgcgg cgagtccagt 46200 aacgtcggtc acggtttggt cagccagaac aatcacgggc atagacatgc gttgcttacc 46260 agtgattttc tgtaattctt ccagcttgta gtctttgtct agcttcagaa tttggtgttc 46320 aataccgcga atgcgacaga tgttttcagc ttgtaaacat tgcgcacaac cttgtttgga 46380 ataaatcgta atcatttctc acctttaggc aaatttcaga ccgtcggaga ctgatccagt 46440 aaggacacca gtcagataat caggagcttc cgcttcctgt aatgcatatt gcattgtttt 46500 attatctagc cactcattta tccatggcac cggattgtct ttacgggctt gtcctgggta 46560 tgggtggcca atagccccca tacgatgtgt tgccaaccag tccaccattt gatgaaggat 46620 attggcattc agtcccagca ttgagccgtc tttgaacaga taattcgccc attctttttc 46680 ttggttgaca acgtcgacat acatctgggt catttcgccg cgcagttctt ctctaataat 46740 ggcaaaatca gggtccaaca gcggcagacg gttcaggaaa gtctgggtca ggatgaggtg 46800 atcttgctca tcacgagcaa tctgacggat gattttagcg ttgccttcca ttttgttgag 46860 gaattgcatg aatgcccaag aacacgcaaa tgaaacatag aaacgaacgc cttcgaggga 46920 gttagcagca aacagagcac gccagaatgc acgcttggcg ttcatgatgt cttcacgggt 46980 gaacgcgcgt ccagccatac gcatcccgct gtaacgcacc atgtcgtcgt agtacacgct 47040 gatctgtccg gcgcaatcga cgatctcctg aacgtccaga acatggtcaa aaacgatacc 47100 aggatcattc actgtgttac gaaggatatg cgtgtaagat agtgagtgga tggcttcttg 47160 gcgcgtccac tccagaatag caaattggat ttccggagtt gatgcccatg ggccaaacgc 47220 ttcgaacgga gcagcgccct gaatagagtc cagcatggtt tggcgtttca ggttgctgaa 47280 gtagatgtgt tgttccgcag cggatagagt ggcaaagtct gctttgtctt tggtgacatc 47340 cacttcttcc ggacgccaga actggctgag acctttctca taccacttct gtacaaaagg 47400 ccatgccacg atgtcatagc gctgaatgct cacagggtcg ccaaagaacg gcagtcctgt 47460 attatctgaa gatgggtcaa atactgaaaa ttgcttttgt tcgttcatgt ttctttcctg 47520 atgaataagg ggtgacgaat cacccctgat attaaacgtt tgtgttgtat agacctaatc 47580 aaacaacaca ggtatcacaa atttcttcaa cttgtttcaa ctcttcatct tccttggagt 47640 ctttgttggt gttgtaatac agagttttac caccccacat gtagaaagac agaatatcct 47700 gcatcataag agagcgcggg atcttgcctt ctggatattt ctctgggtca taccatgtgt 47760 tggtactgat agattgatct acccaacgtt gtatgaccgc agccgtcttc aggtattcaa 47820 tacaatccag attccatttc aggtcatata gaggaccaag ggtttcaacg tccggaacga 47880 tctgcttgta gacgccatcc ttgctgcctt tgatactgat gaggcctttg ggtggctcta 47940 taccattcgt ggcgttcagc acctgagagg agctttcagt tggtgctacg gctaacaacg 48000 tggcgttacg gatcccatac tcggataggt tctgcttaag accttcccag tcaagaccat 48060 aggcttgccc aacaggcttt ttgccattgg gtaggatgtc cagcgggaga ggctgaaggt 48120 cggctgttac aaatccggaa tcatggatag ttgacttctt acaagatccg aaacgcatgg 48180 ccagacggtt ggacgctttg accaagtaga aatgaagatg cgccatccac ttgtctagaa 48240 gttctaatcc gataggcgat ccataacccg tgaaattctt ggccaggaaa tgtgcgacgt 48300 tgacgatacc gatacccaga ggacgatatt cttctacggc caaacgggct tggcgagctg 48360 ggtagtcctg atattccaac aacatatcca aagctgaaac cagaacgaaa gcaacatctt 48420 ccatttctgt tggatcttca aatgccgtca ggttaaatga tgcgagtgta cacagggcaa 48480 tgcgaccatc ttcatcatca tactgttgga actcacgagt cgggagcgcg atttctaaac 48540 acagattaga gctataaatc gtgtccaaat tgaacggact atactcgttc atgtgatcaa 48600 cgaatgcgat gtagatccgt ccagtgtcag aacgctggtc tagtagcatt tggaacactt 48660 cttcagcttg cagctttttg gaacgacata atccggcgtc ggcggccttg atcatattgt 48720 cgtacatttc gcggaattta ttgacgtctg cgaaaaatgc ttcatacatt tcgcggttgt 48780 cttttggatc aaacaggtat agaggctgtt tgttcaccag gcgctcgaac atgacgcggt 48840 taatctgaat cccatagtcg atacggcgtt cacggttctc ttccaatcca cggttgtttt 48900 tgagaacaac gacatcatca aattgataat gccagatggg aacatagcat gttgccgatc 48960 caccacggat accgccttga gagcaagact tcagggcacc agtcaaatac ttgatgaatg 49020 gaaccagacc tgtatggacc atttcccctt tacggatagg gctaccgatg ccacgaattg 49080 ccccaacatc gaatccgatg ccagcacgtt tggaaacata atccacgatg cttttcgcag 49140 tggcattaat tgagtccaat gtatcaccag ttttgatcaa tacacaagag ctgaactgtc 49200 gggtcggggt gcggacgccg gacataatag gtgttggaag actgaatttg cctgtactgg 49260 cgtattcata gaacttcttc accattgtca gtctgctttc tttatcccac gctgagaata 49320 atgccatagc gattgccatg tacatgactt gaggggtttc ataatacact ttgctgtcag 49380 aagaacgatc acgcaaaaga tatttttgag tcagctggcc cattgctgcc caagtgaaat 49440 tcttgtcgcg tttgtggttg atgactgtgt taagttcttc gaattcttct ttagagtaaa 49500 gttcgaggaa ttcgcggtca taaacaccca gcttggtgtt ctttgcaaag atatccagca 49560 aatggggtgg cttgtactga ccatagacaa ccttgcgcag gtcatacgac ttcaggcggg 49620 cagcaacata ttgatagttg ggtttatcaa cagaaattaa ggtggccgca gcttggataa 49680 tgatatcctg aatgcgttcg gttttcatgt tatcggtgaa ttgaatcttc gatgtggctt 49740 ccacctcaga caccgatact ccttcaaggc cgtcacatgc tcgttcaata acggtatgga 49800 gtttttcaat gtcaaagggg acagaagatc cgtcccgctt tatgatgtta atcatagcga 49860 tcctcggttt gtgtttatgc aggctgttat tatacaccgc ctccatggat tgaaggcggc 49920 ggggaagttc gtgtggtatt taaatgttgt acaggtcgtt aatttctaac atcaggcggg 49980 tgaagttgcc gcgaccatta cgatcagact tatcgaattc gatgatgctg aatggttgaa 50040 cccactctgg atattcatct ccgatttcta caccgtcaat ttgcaaggaa cctgtttcca 50100 gcttattgtt gaagtcttta aaggaatcca catacgtctg taacgcactg tcacgcagtc 50160 gcttgttaga ctgtttgata tctccattca cgaagatgta cgaagaatct gaagcacggg 50220 tcagtaagtt cttcagctgc tccatatcgc attcctgcgc ctcttcgata atcaggaaac 50280 aatcatcgaa agtcatcccc tttacagttt caaggtcttg aatttctatg atgcgtttct 50340 cccacagata gttgaagaaa ccgtcggaac ccgtatctgt tttgagaacc tttttgaatg 50400 tctgtatgag cggcatcaaa taaggcatca acttttcata tgtatcacca ggccggaacc 50460 ctgctgtggt gccagttgga aggggagaac gcgtgatgat aatcttgttg atggttttgt 50520 caatcagatg ttttgctgca gcagatgcac cacaatagga tttgcctgta cctgccggac 50580 cgatagcgat agtgagatgt tcattgagtg cggattgata tgcgaggttc tgattttctg 50640 agaggccatt gaacggagca attttgaaat cgcctttgga aaacttcatc cagtcttctt 50700 ccttctggat ggtgtctttc ttacgagcag attttgtctt cgctggcttc atggatacaa 50760 ctttagacgc agattgcatg ttgaaccttc ctatatctac aggggttgtc gacaccttta 50820 attaagcgac acgcccagca tacctgtata tcagataaag aaaaaggccg tttccggcct 50880 tgagaattag cagaaactct tgtatgctac cgccagtttg gtgtcatact ggttcttggc 50940 gtatgctgga ccattgtacc gacgggcgaa ctcagcccaa tttttgttct tcagggcttt 51000 ccacatattg gcatcagcct tgatgaactt gacaaatgcc agaaggtgag cgcgttcacc 51060 agtcaggaaa tcagtgaaca tctctttggc atttgaatag ccacagattt ggcagttgaa 51120 ccccatgatc tggaataggc cgtaggaagc actctcgtaa gcgcagtcct cgtcaagggc 51180 gattgcaccc tgaaggcgtt ccaactccgc gtctccgccg atatacccgc cagaattggg 51240 gttaaccaat gttggataga gttggtacag agcattggct cttgcttgcc cgaatttggc 51300 cgtcaccttt ttgtacatga tgtggcgctc aaacagagtt ttgatcttgc cagttttggt 51360 aaaacccgtg ccacgggatt ctacctgatt cacagctttc atactggcca gctcaatacc 51420 aagttcacgt gctgcgtcaa ccaagtccgc ttcggtcaga tgttcctgat gagcgtctcc 51480 agcgttgcgg atagcataga aggtctttgg cccagcaata ccatcaataa ccaatccagc 51540 acctgcctga acggatttga ctgcattctc tgttgcttta ccaaatatgc catcggctgt 51600 aagggagaaa ccgattttgt tgaggctttg ttgaagcgct ttgacttcag aacctcggtt 51660 gccaagtttt agaatggcca taagaaaata cctccgcaat gtatgcgaag gtatttaaag 51720 tgaaagtcga acttgaggat ttagtgtcga ttatctgact acgacgacag gcatgatttc 51780 tttgaaggaa gtcctaactt cggaatcata cccatatttt tcaaatattt tcaacatcgc 51840 ttgttccagt tcctcttgga actgaggaaa gtgcgcgttg ggaattcggt cggcaaccca 51900 tagagcgcca ggagaggctt ggataattgc tctactcatg tctcattctc ctaccaaaac 51960 tttgaaaggg ggaggtttcc cccttgcggt taagccagtt tgttcaccag agtttctact 52020 gcgtcggcgc tcagtttacc cattttgaca tactgggatt tcgcttcacc gccagcggct 52080 ttcacgatat cactgttgtc ataacccttt ttcgggaata ccatcacgga gaaggttccg 52140 ttgttcagcg ggttcagctg aatgcgacct ttaccgacta cgatggtgcc gtaagtttcg 52200 gtattcgctt cgacaacgtg gatgtcatgg cccaggtctt tcagcatgcc aactttgtca 52260 gcagtcttgg caaccacggc tttgtctacg acaacctgct ctaccagggt gaagccgttg 52320 gtcgctttca ctttgccgtt cagcagattc atgaaggaag ttttgccacc agtgaagcca 52380 gctgcctgag cgatgcggaa catttcaact tttgcaactt cggtgttcag ttcaaaagag 52440 atggtgccgt tggtgatcag agttttggta gtagccatga tgtaattcct cataatgtag 52500 ttgggtcgtt tcacttttca ttcggcgggg tgttgtgtac cgccctatgt gaactataat 52560 agtgcatgat tattgaagag taaagtcttt ttcaataaat ttttaaatta tttttgaagt 52620 attttaaaag gcctcgtaga atgaggccta gagagaaggt ttttgagtta aaaagtttta 52680 ggtcggcttc tttttcaaat actggcgagc caaattcatt tgttcttcag tgataggaca 52740 accgccgaag tccaccattc cgttcctcca accatggatg aaactcttag attctaaacc 52800 agataggaca tatccttcac gggcttgcat atacccgcga agaatctctt catcgtccat 52860 actattcagt tcttttaaat ccatcatatc ttcctcaagt cagaaaatcg taaggacgcc 52920 gacagtccct gatatacgtt cttggctatg atctgaagca gatcacgtat cgggatattt 52980 cccttgtcgg ggcgaaccat atcattgata tccttccacg gtatttccgg tggaaacaga 53040 acgactttga ctccgctgtc tatcatcttc tgtataccgt cacaaacttg tttgttcctg 53100 tattggttat cggggatata gatatccccc ttagcactta ataagtcggc atcggcagtc 53160 gcaagacaat taggtagaaa caagctatca attggacctt ctactaccaa ctttgttttg 53220 ttccaaatga tgcgctcttc cccgtagatc ttagtatctt cgttcttagg cttgacagtg 53280 gcataccgta ataccccatc aggaaggtta tcgccgaatg cgcgcccctg aactatcttc 53340 atgcgcccgt cttgggtcca gaatgggatt accagccgct catcttcggg tatcttcttt 53400 tgcttctcaa catccgtttc aaaactcaga agatcttgac gaaaattcct gctgtaatat 53460 aacaaagata acgtgctctc cggcattccc ctgccttcaa cgtaacgacg ggcgatatga 53520 tcacggtcaa gaagatcaag gcgtatcata ttcccaaggt gctcttcatc ccgtttggcg 53580 acctgagaac cgatacgtgc tgtctgggtc aggcgctgta atggtttgag tttttgtaac 53640 gggcgggaac tggtatcccc cattatcctg aatttttcaa ggttgtattc attatacaga 53700 cgctcgtcaa acttcttcaa ccagaattca aacgcccaac cgctcatttc attacagttg 53760 tggcacttga aacgaaacac atcgtcatca cgatcataaa agaagtgacc acgacgcttg 53820 ttggcactct tcttagaatc cccacataat gggcaacgaa atttggcgac agcgccaaca 53880 cgttcccaac tgaatttatc aagtcggggg gcgagaaaat tgatgtattg ttcgtccaag 53940 aatttcatta gatatttggc ctctggaaca cttctgtcac attataatcc accccgcgac 54000 tttgagctat gcaaagctgt cgccaagccc catacagaat attttgttcc gcaacctgat 54060 tgcgttcaaa gcgggcgaat tcttccagca tctgtttgta ccctaataga taaggaggga 54120 tatctatagg tcttcttttg cccaaagatt tagacaaata tgatgcataa tgttccggtg 54180 aagacaaaga ggaatattgc atattcggaa cgtgaacggg cttcaaagat tttctagggg 54240 tgaagtacaa caaaccccac ttgggaggga ggtcttcaat tttaataaca tctgctgggc 54300 aaacatagaa acgatatgct cccatgccta tggaaggatt catgcgatga ggtttctttt 54360 tgtctgtcag gaagtcggcg cgggagactt taacttccat taatatagaa caacccccag 54420 gtctgaaccc gatggcgtca ggggattcac gattatcgaa tgaatttggt tctacgaaca 54480 cagcaccaca attcatttgt ttgtgtagaa attttgcagc gatttgacaa ccttctgagt 54540 gagaaggtat aaagattttg cccattgtta tctgtatcct attgatgacg aatgggcaaa 54600 attataacct gacgatgatc ctattgagtt aggacaattg cttcagtttg taaatcgttt 54660 gatagcacaa agttttgatt tcatcaagcg tattttgaag atggctgtcg cattgaccat 54720 aaattccgtt tacgtcgata acaacactgt tgacatacga tataggatct gggttgtaca 54780 gtttaatatt ctcaaaccct gggacatata caccacccgc gccgatatat gcctctgtaa 54840 aggtatccag caagtcctcc agttccccgt agaactcccc gagtgccttg tgcttggcat 54900 aggacgttgt aacgaagtgg agggcatgag agtgggctat agcaagcagt ccacggttga 54960 tgaatatact cgcattgacc atgattgttt cctcagaaaa agaaatcccc ctgtatttag 55020 ggggattgtc atcaaggctt gatcaaagtc agcttgacgg tttcacccgt gctggtgttc 55080 gtcagggtca taatgttctg tgcgttcaca gacttcactt tcccctgatg tttatccccg 55140 ttgcgatcat agtaatcaat cagatcgcct ttgttagggc ggccaacgtc ggtgatgtca 55200 tacatgccct gctgtccaag acggcgatgg tcaacctttg cttccttcaa gaggaagtcc 55260 tggaatcctt tcatacaacc tccttagaca ggtttaacgt caatatattt ggcaatgtcc 55320 gcagctaggg ttttcccctt actgatgtca tgctgtttgc cagcgactgt gacaattaca 55380 tatggatcgt cttctccgcc gaagtcgatt gcgacaggtt ttccaatacc aggaataccg 55440 gaatattcaa actctgtacg accgctttta cgagatttgc caacgcccag cgctttaccg 55500 atcatcttat ccatgttcgc caattcttgg gcataggatt ctgtgacctg acctttgctg 55560 gcatctttcc caaagaagaa ctcaaaaccg tcatgaacgg caaccacatc tttaccgaca 55620 gaaactgcat gaacctggtc cggtgtgagt tttactttgg tggtgttacc gttagtcaat 55680 tccagattat agatgtcggc ctgattatct ggagtgatct gggttacggt ggcaccagta 55740 caccattggg ttccgtcggc ctgtttggtg atggttacac ttttgccttg tatgccgcca 55800 tgagtttgcg gttgttgagc ttgttcttta aaatattcga taaacggttt catcgtggat 55860 ctcctaagga ttttgatgta tttagccccc gaaggggcta tgacttattt cagactaatc 55920 tgaagattac cacccagcga ttgttcatat tcactgtatg cactatcacc attactcaca 55980 gcccattcgt cggattggcg agcgcgttca agagtcatga gatttggctc ggtaggatta 56040 tagcctttag atttcgcgtc gttgtatacc gtttgcaggt attggttggc acggtttatc 56100 tgatccttga attcacgata tgctccttcg gtcgtattgc gacggaaagt gatatcccaa 56160 gcaacattca gaactgtacc attactggct gtgtatacct gccaatccag atctcgtcca 56220 ttaggagcgc tatcacgaat ggatccggca taggtggcca gatcacctgc attcttacct 56280 ccagcagcct gatctttagc ccgagccaga gcatcaatga ctgctgtgcg gttcctggac 56340 tgtgccaaat ctttgtcttg gaacataatc gcaccaaatt tactgacagt gatgtcattc 56400 aggaatagat tgttagggtt atagtttgat gaactgaggt ggctcagttg cgaagccgcg 56460 tctttcaagc gacgagaaat ctcgtctaac gcatcttgca ctgatttgac agacaacgaa 56520 atatcatatc cattgctgtc tactacattt cgaccatttt cggtcaacat ggtggtgatg 56580 ttggctttgt ttcgatcaaa atcgtaagtt acgttggtaa cgaatcttgc ggcttgcaac 56640 ttgctgccag cagggaactg gaaatcccac gccacagaga agccatgaac ggtttcacca 56700 aaaaatttag cgttgcttgg tactttgatg tttgcagtga tcactgcatt ttcactggaa 56760 ttggtgttga tttcaccaaa gatagtacgc tcgccggaag attgaaccaa cagagtatct 56820 tttccacgcc aatcatagcg gactttgaat gttgtacgag gaaactcttt catcagatca 56880 agtttgaccg ccttgcccaa ggtaaaccga ttcagcagag cgtcagcgat cttcaatgtg 56940 aaagaaccac aatcaacgta agaatatccc tgggaacggg aaattttttg aatcggatat 57000 ggggcgttat tgataggaac cacacggcat tctacttctc cagcaaattg agaatcggct 57060 gcacgggaga ttgcgcccac tatttcataa gcggcgtttt tcacgtctcc ttccagcata 57120 agttggtcat gaccagacaa atctgatact acttctacag aaagttttcc gttgacaatt 57180 ccccagaaat aaacctgaat gtccagacca cccgaagtac gatatttgcc cgcaccgatt 57240 cgtgttagtt tctcacctgc atacataccg acctgttgtg gagcatatgt atcaacgata 57300 cccaagatgc gggcgatata accctggttg cgcagatcat ccatagaacc ggtttttggg 57360 agagttttca tgtcggcggg tgtcaagttt gtttctctag aatcttctac gtttagattg 57420 aacaattgtt tcccagatga gtcggaagca ataaattcat atttcttgcc actgcgggta 57480 ctcgtgctgt taactttgat gtttccagtg tatcttcctg gattcgtttt ttgcatgaaa 57540 ttggtaattg cagcagaagg ggttttcatc ccagaaatga ttctagctgt ctccggatca 57600 gtgaaagaca ccaccaattt acgcccatcc attaccgata cttcatttcc agaaactgaa 57660 atattcaagt tttccatttc agaacggaaa tcgatgccaa caataatagt ttggccagtt 57720 ccacccacaa cgctatcaac gctgttctga accggaacgt cacccacctt gtctggatca 57780 tcccaggtaa tgccctgcat cttcggaccg tcaaatacct gagcaggatc cttgccttta 57840 cgcacaaccc atacgaatgc acgatcaggg ataggggtat acgtcaggtc catgacattg 57900 agcttctgct tcaggccgga ctgacggatg atcttcggca ggagggtaac accacgttcc 57960 aatgctttct tggagaagtt aattgcaaag ccgtcaatgg ttttccccaa aggcgtcgcc 58020 atgaattgct ttgttgcttc aatcatggat gcgatgacac gcattgggtt tttgaaacga 58080 ccgatggcat cgggatatgt ggaaccacgc ttctgaccga taaagacttg gcgaacattc 58140 ttgcctagac cttgtggggt atagaattga atacggaatt ctttttcgtc ttcatcaaca 58200 aatgtgaaga aaatgtcacc agcgttcttc ttgccgaatg tcaattcata cggggatgag 58260 ttaaacgctt cgtctaattg tttagactct tcaagaaagt tcaagaaaga tgggatggcc 58320 attgtaattc tcctgattat aaaatcggtg cggtttccct taattagcga aaagaaaggg 58380 gtgcttctta acgacgaaac gggcgagacg cattttggcg attgttgtaa ttcttatcaa 58440 attgtgccaa cgccgccgga ctccattcgc gttcccattc tttgtcaact tcggtttggt 58500 tggcaggttc aatcatttca gcagtaggaa aatcgcgttt cataatttca cgcaattgtt 58560 cagaaggggc ggtttgggcg tggactaatt cttcaccgtc gtaaactttg gccatcaacc 58620 attttctgcc gtaacggata tatgcgtcga ggatgatttt cataatgtag ttcctgcttt 58680 tcaagttggt gtcgtactgc ttatgtttag aattatactt gggttattga agaagtaaag 58740 gggcttttgc cccttttatt gaataattta aggtgttgga ttgacaacgg gaatatggaa 58800 cctgatccca gagacaatgt ccttcaattg tggctgccaa cccgtgacca aacggggtag 58860 cgcattagaa ccaggataga caataatgat gtcgcttccg gttacattat gttgagggaa 58920 ttgtgacatg tattgctcca tcgtcacccc tgggtctatc aacacaggac cgacatccga 58980 agatgcatat gttgccccca aaccgtcgac gccccatgct agtattccat aatcaggaat 59040 attggcttca gaagttatgg tgaatccgaa gatacgattc agcgcagaaa aatcatacac 59100 gccgtgagca ctgtcatatg tcagataacc ctttgacagc atatcagcga atatcgcgtc 59160 tgtgtcacca gttgccggag tcggtatggt aaacaataac tcaccagcag gaggggatgg 59220 atacgtgccg agtgcataaa ggcaccaagc gtcgatgcat ttcttgatga atgcttccgg 59280 cgcgacataa tccgcaaggc gcattgtacc ggaatattct gaagtaatga tcccttcctt 59340 cgcgccctga atggccagaa ataccattat gtgttcatat ccggtctgag atggagtgat 59400 attcattatc tggtcctctt gagtttctca atcgtgcgct tattcatggc gatcactcct 59460 gggtcgacct ttgggtttat tgccatgcct ttgaaagaca cacatcgttg aagatattta 59520 gccttcttca cgacgtcggc tgcataagaa ttggatttct ggttacgatt gaacccagca 59580 ttgtaagagg aaagggattt gcggatgttt tggttatgat attctagcca gaaattcatt 59640 tcatcaaggg cagcattggc agcatattct tgattgacca gtaatttgat cgcgacattg 59700 gcgtaacact tctgcgtttt gcatccctcc cgtttcccga cggtttggac gcgattttga 59760 aatgccccca tattagccga tttgaggtta ttccgcatgg atacaacatc ttctccggcg 59820 cggctttccc tccatgatat tgcggcgaga gtgaaaccaa ggtcttgttg ttttcccacg 59880 tgataggctg tggccatggt tgaaagttgt tgatcagaaa actcataatc acattgggtg 59940 gtactttggg aagcgtgcac actcccgctg gcaatggtaa aggtcacgga caaggccatg 60000 gccttcaacg ttgtcatcgt catgatggcg ttccttatgt gtttgtcgac ttgcagctcg 60060 ctggagcctc ctgacagggt taaaagataa agggcacgtg atatttagtg cccttcacct 60120 tattcgtaga tcagatggta tgattcctcg atgcattcca accaaccgta gacaaattcc 60180 ataggatcat cccaagctgt attggaagca atagtgaaat ccccgtccaa gatttgcata 60240 tctgtgtact tgttgaaacc caagacggcg tcaacaacga tcaacccacc ttgctctagg 60300 taacgttttg gtgtcaatgc tacctgatga tgtttatttc gctgattcca taattccaca 60360 gcgatatcac aagcaatctg tatttcatct ttctcttctg acatatgttt gtctcaaata 60420 ttcagtaaaa gatttaccca acttacggaa tagtttaata cgaccgatca ctttgacgta 60480 aacatccccg tggcaggggc gtggtttaca ccagcactaa ccatcatgtc atgtcctcat 60540 aattcgatag atttatcagg aaagacagat tccggtcttc gacaaggtca attgccttgc 60600 gactgcccac agcctcacat gtccaatact tgtaattccc tgcgatcttc atcgccaaac 60660 ggataacgcg tagcttcatc tggtactggg cgacttggta gcggacacgc gtcttcttgc 60720 gccagcattg attctccgct ttgtacttgt agaggatcat caggcgaacg gctttgtaca 60780 ggcgcttttc agcgcccttg gatttctttg atacacggat cagacttccc atgatcaatc 60840 cttcttaatc acttcagtca tgccattacg cagaccataa cggatgttgt gttggaaata 60900 ctcttggaat tcctgctcgc gttgactgat aacgaacaga ttgttcccgc caaatttatg 60960 cttcagcatc tcaaccgatt cttgtacgcc gcgctcgctc atgttctcaa ggatttcatc 61020 cagcacaaac aggttacatt gcaccgacgc cttgaggttt gcaacatctc gtaaagctaa 61080 tgtcacagcc aggttcaggc gactacgctg accagtagat aacgagaaga tgctttgccc 61140 tttacgacct gcagcgctca tggtgatttc aaatgtatca tcaacagcaa tatccaagaa 61200 catattgagt gcttcaagat actcgtttat tttactattg aggaaaggca aatacaggct 61260 gataattcga gccttggtct gatcatcttt taggaagaac agaagatggt tcaggtcttg 61320 caatttctca tccaactcta cgcgccgcgc attcagatct tccattaatg ccgtgatgcg 61380 agcgatctct ccttccaggg cgtcagttgg tgtcggctta accgccaatt tacgctctaa 61440 atcggcaatg gatgcctcta gagggacacg gcgtgatttc aggctggtga gtttatcagc 61500 cgtgtcgttg atactcttag agagctgctc acgcgcttga cggattgacg tcgtgatatc 61560 ttcataacgg gtgtctacgg ccttgaggac gtcgttaatt ttggactgtt gttcccgctg 61620 taaagatgtt ttctcaacag cagcgacatc atagaatcct tggatgtcgc gttttaatgt 61680 agcgatcgct gattccgctt ctcggatttc attgcgcaaa gcatccagtt ctttgtcaat 61740 aaccgaaatc tgagaagata attctgaatc tctgacattg taattctcaa tcagggaatt 61800 cacttcttct agggctgtat caacctgaag aatcttgtca gtcagttcac tgatttgtgg 61860 ataatattga ctttcaatgc gtgatttggt atcgtccgac actaattgcg tacacgtagg 61920 gcaagtgccc atatcgtgga aacgtttgat ggcagattca tgtccttcca tttctgttac 61980 gaatttgata cggaagttct caccctgctg acgccgcgct aatgctttgt tcagttcatc 62040 caggttagca ttccgttggc tgaccagatc atttttacgt tccgcgacta ccgccattct 62100 ctcccgaatt tcttgtaatg aacgttctcc atcagacacc tcgatacgct catagtcttc 62160 agccttggta tcagcctcat cctgaaccgc ttgaattttg gcaaaatact cgtcattgat 62220 ggaatcgata tccaccttca tttcagcgtt caggcgatta cggacttctg ataattctga 62280 tttcaattta gagtcttgag cacggaattc cgtcagttct tcttgagaag caccaatatc 62340 tgaattcaaa ctattcagac gttccttctc ttggacaagg atatccgcag attgttgctg 62400 gatcatcgca ttggaattat tgatctgttc caactgcgct tgctggcctt ttaaatttac 62460 atcatgaaag gcgtaatcat tggtgaccgt cgtgagttca ttcgttactg tcttgataga 62520 tgcttttaca tcttcattca tcaaactgaa gaaccccaaa tcccagattg tctctaccat 62580 agcgcgacgg tcggcagtgt acatttccgt gaatgggatg aacttctctt tgcccagaac 62640 cagggagttc tcaaacatct tctggtctac gccaatcagg ttcacgatat atttgttcat 62700 gtcggctttg gccgcatcat tcacgacctg cttccactga ccgtctacca tctgatagac 62760 ttctacgaaa tcaggtttga taccacgacg gactttccat tcacttccgc gagtagagaa 62820 ctcaacttca cccacgcatt cctttttgtt ttgggaattg actaatccgg ctttcttttc 62880 tttcttgctg tatgtgtcgt tgtacagaac gaagaataac aaccaaacaa gcattgtaga 62940 tttgcccgcc ccattgtcat cagatgtgac tagggttgca gggttgcgtt ggtaatcaat 63000 ttccatgaat tcattaccga tggaacggaa gtttttagcg cgaccgcgat ggaaagtcag 63060 tttgtgggta atttccccac ggatttcaaa tggtgcttca acagaaacag gagtgtccgc 63120 ttctttcaac agcgaaccaa attttgataa taggtctaca ttgctcatta ttatgcatcc 63180 aatgtgttca ggcgttgttg ggcagcatta tagaattgtt ctgctaattt gcaaacattt 63240 tcagggcgct ggatattatt ggcggcgcgg atatctttct tcaggacttc cacagcatca 63300 gtcgccacca tctcttcagt gacttctacc ttctcggaag caacagtaat cgtccgatcg 63360 atgaagttgt aatcgatgca tttacagcgc ttcaatgcgt cacagaactt ttcataatgc 63420 ttggcattgt cacggttctg tacaatcacc ttaacgattt gcccttcaat acccaaaaca 63480 ttgtttaacc aatcggggtc gatccaatta ccttcagtat cagaagacat ttgtgtgtag 63540 tcgtattcca cgaaccggaa caacgtttgt tgttcgttgt tggggataaa caattccccg 63600 ccattcatgt cgtctacata gaatcctcgg ttcgtcccgt ctttgtggtc ttcccaggta 63660 aggtgataag gagtcccaat atactgaatg ttaccttcca tcgaacgggt atggaaatgt 63720 ccggtatcca cgcgctcgaa tttcgaaagg agcgccaagt cgatctgacc tttatcacat 63780 acagaggact ggtacatttt gaaccctgcc aactccagat gcgcaaaaca gtacttggcg 63840 tctgtatctt gtatcgcttt aatggacgca tcatagttct ctttgttaat ccacggcagt 63900 aggagggtct tgacaccttc aatcattact tcagttggtt cgctgtaata atgataaaca 63960 tctggtgcca attcattaag ataagaaggc cagttaatgc gattggactc ttctaacgtg 64020 atatcatggt tgccgacgat gccattccat ttaatacctg ctttgcgcag ggctggcgtt 64080 aattcatctt tcaaccaatc tttatcgcga ccatacatga atttgcgaac atcaaacgta 64140 tcaccaaatt gccacacttc tttaatatcg gcgtcaacca attctggaat aaaataattg 64200 atgagataat tctttatgaa ttctcgaacg taacgggaac cattacggct cccgatatgt 64260 aaatcgccaa ttttagcaat cgccattatt ttgttgctcc cgttctaatg ctcgtttctt 64320 tgcttcttcc caatctggtt ccatagaaca tatttcgtct tccagattga attgagtaga 64380 gccgaagtca tagtctgaat tatcttcggc gtcggcggta atggtatttt cactctttgt 64440 gagacattga agtataccgc gaggaatttt cttattcttt tcctcttctt tgatggcgat 64500 ttgcttttgg cgttcctttt cgcgctgggc ttctttctta gtttcaaaat ttccgatacg 64560 ctcacggaag tccattgtta taccagtgct gtctacgaat gtctgttgct ggaagtctgg 64620 gtcatctgat aatgcagcga aaccacctgc ttcttcaaat gaacgcaact tgatataatt 64680 gtgttcttct tcactggtga gtttcttggc gaatgaacga tcggcgcaca tcgttaccca 64740 agagaagaaa ttgatttttc ctttcttgcc gatatgactg acgtcaaatg tatggaggta 64800 acgaaggatg ttgacaacgg cctcactgac catgtcttcg cggtatggat aatcacgata 64860 gttgtagcgc atactcatgt tcttaataat catctgaaca ttcatggcca cataattggg 64920 gattcttggt aggggtgttc cttcggccaa agcctttttg cgagccggaa tccaatctct 64980 caatattcca acaacacggt cattatcttc gtctgtgaaa tatttggtga cgttatcacc 65040 cctgtctaca aaattcatac ccatcgtgat aatcctcaaa taccaatgaa ttcattgaaa 65100 gaaccaacga ctttcttgac cgagaaacgg ttattttcaa gaaccattga actatcttct 65160 ttggctctaa cgctccactg atccgcaatt tcgttgccca tcgttcctgc atgacctttc 65220 acccatttta attcaagttc acaaattgaa caaactttgt cataataatc gaacaactcg 65280 agcagaagtt ctgtgttctt aggcggcatt ccttcatatt cccatttacg acgccactcc 65340 aaaacgctat tgataacata ttggctgtcg gatatgatgc gggctggggg aatgcagcgt 65400 tcaccgcaat tagagaattt ccataggatc ttcattgcgt ttataacccc gagtaactca 65460 gctatattgt tcgttgacgg cgggggtaaa tacccataaa acactttcca ttgctctcca 65520 gtgattggac tgatggtaaa tgcccaacca gcggctcgtg tcttctgagg ggacgatgcc 65580 ccgtcagtgt atatttcaat catgtataag tatcccaaac tggttttatc gatgaggaac 65640 gaatcatgtc agaacgcgca tatcgtttca gtctgaccgc cccagaaatt gagcgtttgc 65700 tcttgtccat aaacgactcc atccaaaagc tggacatcgt atatgactac acggcgggtg 65760 ggactgaagg tcaggtcgca gctgcgtcag ctgttaagaa catgtggatc aaactcaatg 65820 agatggtcac aggtcaaggt cttaaagacg caattaattc agctgacgac agtaacgtat 65880 tcaccgatca ttataagtct attttagatc gcgaaacttg gaaatttatt ggttctccgg 65940 cagatttatt agcaagggac gatatagaca cttccaattt tgaaggcggt gaagtaatac 66000 tcctacaaaa gaacgcttcg ggcaacccag aattccaata ctggaaaaga actcctgtgg 66060 caggaggtga tccaatattt ggttgggaat ctgtttatga aggaaactcc aacgactctt 66120 ctattgatat tccggttgtt gggaccagca tactgaagac aatcccaaaa gcattgtttc 66180 atatggtcga attccgagta cacgctcgag agtctaccct cggtcattgg caagacactg 66240 atggcaaaat cggttatcgt ggtgaagatc tgatttatag cctgtataat catgttcaaa 66300 ccaaaccgat cgcaaatata tctttcagcc aagatgtgga caatatgatt atcacgataa 66360 cgacacttga accaaatatc aagtgccatt tatcgtttat tgcgggttat taaacctcaa 66420 acactgcatc ggtgaaccag gttgggaaga attctgggtt gcgcatcata agagattcaa 66480 aggatgaatc aatgatgtat gtcgcagccc agtcatcaac acccctgacc gaacgcccac 66540 acatttgaac aatgcgcagt actgcattgc ggaaatatgc cgacggatcc actgaattga 66600 tatgtgctat cagtggatcg cccagataat cataagggac tttgatcagt atttggaaac 66660 ggctgtaatc ccctttgaaa tcataacctt cttccatagc cggactggca atgacgcatg 66720 gggactttgt tctaaaagca ttttccataa tatccatcaa cgcctttcgg gtacgcggaa 66780 catggataaa attctgatat ttgctgaatt tttgtattgc caaggcacga tcataactca 66840 ctgtatggat aatgccggac tgacctgggt ggaacgcgat tatttcatca atatattccg 66900 tcaacctttt catttcatag tcgcccatat tgttagtcat cttcactatg ggcatatagt 66960 tgacttttct gttttcaatc gggatagggt tgccgatctg aatggaatga taatccccct 67020 gtcgaatacc caatgaacga gcatacgaat ctataccaca gatcgttgct gacatatgaa 67080 cgtgataatc agcttttcgg aataacccga attcacttac atcagaaggc ataacgggtt 67140 taaaccgaat aaagtcatct cccttttcct gtacgataaa ggtgctggcc tttgtctgag 67200 acataatacc acaataatca ctcaagttat gcaagacatc tataatgtct gcgagtttca 67260 tcacttgact ttcactcagg cggtcatctt caaccaattc ttcaagaact tccaacaaag 67320 actccacttt aagatggagg tcttcaaaca tcgaatgcat ttcaccagac aaagaataca 67380 acttgcccaa gacatagtcc ttggtgcgtt ctacgatatc ggcaatgata gagactatct 67440 ccttcccttc ggggatagtt cgcagtccgt ccacagcctt tgtattgtat tccattatcg 67500 tgtgctctag gagcgtagag ggcatcttat gacactcgtc taagatcagc atatcggaac 67560 ggttttcagg cttcatacag atggtggtgc acatctcaat catcatagct gcattagtgc 67620 aacgcaatga cgaaatatca gtccataaat tgcgcgcctg tacataagga caacggcgtt 67680 tgctacaatg cccgtcgcgg catgctatac ggcattgcac agcgttgtaa tacacatctg 67740 ggtgtacgtg gcaacgatag ttcttcttgc ctttcaggat gtctatcgcc accgcctttt 67800 cagcagcata ctgatcttgt agacctttgg taggcgtact gatagacgtg cggaattgtc 67860 cataaggatc ggcctgtaaa accaaatgac gaatcacttt atgaattgtt gtcccaatca 67920 aagatttccc cacgccagtt ggggcttcaa tgattacgtg tttgaccttt ttgttgacca 67980 aggcatcaac ggcttcgacg atacattcca tctggcctgg gttcgctttg tcatatggga 68040 attcatcttt ggcaaggcgt tgtatttctt ccacaggaac cttacggcct atggcgtcaa 68100 tcgcctttcg gtgttgatta aatgctgtca cgttgttcct cctttggatt ctgttatagt 68160 ttacccgaat cccaacaacg aaaaagccga ggcattaacc tcggcttctc cttttagcct 68220 tgcgccgctg cactgcagac atgcgctggg ccgacgcctg gtgtgattac tggccgttgg 68280 cagcagcttt cagaccttca ccaactttga atttaactac atttttcgct tcgatctgga 68340 tctgttgtcc gttcagcggg ttgcggccag tgcgcgcttc ctgatgttta acttcgaacg 68400 cgccgaagcc tacgaattgg acagattggc cagccgcgac tgcagttttc acgccattga 68460 taaaagatgc aacgattttc tcagcttcgc ctttggtcat accctgggtt tgggcgatgt 68520 gggcgataaa atcagtacgg ttcattcgga ttactccagt tggttgttta cgatggttca 68580 ctacaagagg actacagctt acctaacaaa tactattgaa taaagcgttt atttgccgac 68640 gtttagcatt ttacttgagc cagaaccatc aacaatcaga gtacatttcc cactgttggc 68700 gcaagattgc aacaccatgt tatattcgtg ttgtaaatat tcaggtgtca gagatgtcgt 68760 cagtttctga ttcgccctgg cttcttggtc gcgaatttca acgttctttc ttgctgtatc 68820 caaacgtttg tcggccatga cattatcacg gatagattgc tcaatcgaag gatctgtcag 68880 cgcctttttc accaacacac gtgtgattgt gaacatgcca ggcgcagcag tttccaattg 68940 ctgctgggtg cgttccttga tcatcttttc taactcagcc cgttgggtgt gaattgtcat 69000 agaatccaaa gaggaaacgg cgtccatcgt tgaggatgct gcggcggttt taaccaggtt 69060 gaatcccacc gctatcgtgc cgtcaccgag ttcagcgctc tgacctgcaa atttggtatg 69120 gaaccaagga accttcgcga cgttcggtgt gtaataaacg tccacatcca gatcttccaa 69180 ggtcaggttg tctttggcct ttggcgtcat tttagtcaga ctcacaacgg cttctttggt 69240 cgtgtaaaca tccacgcttg aaacaaagct ggtgtagatc cccgctgtta cagggttcat 69300 gtccacttca ccccattggg ttcgaacacc gacgtttcct tcatcgataa caccgccgca 69360 gcctgaaaga aggcttgctg ctaggaccat aattgcgcca aataccagtt tcttgaacat 69420 caatgtactc cttcaaaaat gtaaatataa gcacccaacg tgagtgcagt tattgtaacc 69480 gaagaaatca gcagtaggaa agttactctc acccgtttgc gccaacgttt actccggtag 69540 attttagtct ctttcaaata tttgaaaaag aaaaataaaa tgaatgttgt tattacgaat 69600 atgaacagat aacggattaa cccgatcatt ttacacctgc attttccaca atcgcttgat 69660 aaatgtgacg ttcaatagtt ccatcacaaa aacctggccg aaataaacca gctatcgcat 69720 ccaaacactt ctgagtcggt tgaaccggaa tcataatgtg ttctttgtct tcgataggtg 69780 tgggtaaaca aataacctga ccaaccgtga tatggcctgg gttttgaata ttgttgaatc 69840 tggctaattt gatatactgt tgggcatcac catataattt tagagcgatg ctggacagag 69900 tatccccagg ctttacaata tattttgaaa tcatatttcc caccctgtac tgcgcagatg 69960 ctcgaaataa tcgttgagtt cgtcaacatc ttccatatca acccaacgat catccagacc 70020 catatcatta agatcatcat cggtcagatc atgttgataa atctgaatgc ccgaagcatt 70080 gcaataatcc ggcttgatat tgttgttgaa ctggaacaaa tcataatcac ccagagcatt 70140 cttcaggcgc tgcgcttctt caaatgttgg aacctcaaca tgaaaagcga tcccaggaac 70200 ctggggaata tgccaaacgc gaaatttaag ttcaaacggt ttattcgaca tggggttctc 70260 cctgagacag tatggttttc atctgttcac gcgtgataat tgtttcaaca agattctcgt 70320 caatcatcat ttcgtttaac agttcacaac ccagcacgtg tggtcgcgcc atatacggca 70380 tggcgttgag tttttcttct atgtcaagaa cgcgcttgac ggtcaggccc atcgaagaaa 70440 aagggacagg ataaaagaat gaaatgatct gattatccac cccgtttgaa aatcttacca 70500 acaatacatc acaccatacg ccggacatat tacacctcca ccgagtggga tttaagtagt 70560 tcatcaattc ctttctgccc catgtaagag aacggggtac gctggtagaa cgcccacagg 70620 actaattgaa cgacggcgcg ggaacggctt tcggaacgca tctcaagtcc gcgaaaatgt 70680 ggtgattcgg cagtccattg gatctcttca cccaggtctt cgttacaata caccgaaatg 70740 cggaatttat ggcacaacgc gtctacttct ccgtaagcat cagtggaaac cctgagttgt 70800 tctgcatgcg cccaagaagt cgtaacaatc cgttcgccca tcactttgtc agaaacaaac 70860 caatcgatcg attgagtaaa atcatcgaag tgatcaacac gatagataat cccatgacct 70920 tccatacctt tcatggcatg ataacgcgcg tcaatttcat tattgtgcat cgcgttgaag 70980 tcgatgtaaa cccgcctcgc caacacaacg tcttctggct tcagagagac catcgtcgtg 71040 tcattcaccg tgtaatgaag gatgcctgta ccacgcccac agtcatgttg gcaatacacg 71100 tatttgtccc caccaacacg ggcataagca atataacaag gttctgagaa tcgcaggttt 71160 ccttggtctg cgccaaggat gataggataa gatttgtcca taatatagat ctctcaaata 71220 aaaggcggtt taataataac cgccctaatg ttattgaatt attttatatc accaacatac 71280 atgttcaggg tttcatccca ttctaaacga acgcggatgg ttccggaatc gttagggaaa 71340 gacaacttac tagacatatg tttgttggca tacgttccgc tcttgtttac gggataatcg 71400 ttcccttcac taatagcaaa tcgtttaaaa ttccggctta ccatcatatt gatgttcggc 71460 catggtagtt gttcacgcag agttttacac aatatgatct ttccgttgca tcggaatgac 71520 acaaataaat catttggaga agaatagcgt tgttcttgcg gacacaactg tcgtattgaa 71580 ataaattcgg actcatcatt attttctacc ggaggcttca tagattcttc tcttctcttt 71640 tcaacatatt gttcgaaagc cttttgaccc acaggtggga gcggattatt ggtgacaggc 71700 ataacggctg gtttgatttc cggcttctct gcggatgatg tgcgagcgac tcgaagtttt 71760 tcctgagcct ctaaaatcct ttcttggcgg gttttgggtt tagtttcaac cttagagctg 71820 aaatcgcaga ccgtaaccca atcaccctga tcattgcgct tggcaaccag agtcaattta 71880 tagatgatgc cctgcagctt gctttcgcgc atagtgtctg cgaaccagaa agcacaaccc 71940 tgctcgaact tttcagcgaa gatgacgcgc ccgtcttcgt gaatcagaat gacctttgct 72000 ttgttgggcg cgaacatctt attcttttca atgatcgatt cggcgatctt tttggtaata 72060 atcatcacga agtatttcct ttcagttcaa tggaagttaa attttaacct gaaaattatc 72120 tttgatttcc aacgaaatta gtcgctattt cccgacacat agtcagatct ttgatcatct 72180 gtttgctatt gtcggcagcg gactccatca ttggcaaatc caaagcattc tctatttgat 72240 ccacgctgta aagatcaagg cgtttcaact caccttcata atctgataaa aggatggatg 72300 tatctttatc atcagggtga aattgttgat aagtagacaa ccaggccgca cacatattca 72360 atttgctagc cggagttgcc acaacttgga atgatgccaa catagaaaag aataacaaga 72420 atattatgtt tctcatcttt cgttctcctt catcatattg tcacagtcaa tccgtgtttg 72480 cttgagttca cgcgaaagcc ttgggtcgtc tagattgaca gacaaattag tggaaagatc 72540 tttcagtccg ttctgaacac ggtcttcata ataatgatca ttttccacca gccatgctct 72600 caggccaagg gcgcgagtcc gccattcctt tttcagtctt cgatcagatt cttgatcagc 72660 gctgtattca aatactcgaa tacattggtt tccatcattg atgagatcca gctgacgtcg 72720 gccaacctgc acaccttttt gtaatgctgg agaaggaaga gaacggcact gtcttacggt 72780 cattcgtcct tgtgtaccca tacgaccagc cataataaga tcgctcgcct ccatgcctcc 72840 tcggttaaat tcttcgtcgt tcatatatcc tttcaggttg aacgcgcctt gcttatatcg 72900 attaaactca ataccagcat ttacaacggc atctgtgaca ttacctgtgg cccagagttc 72960 agcaaaattt tctatggaac cagttttgtc tatagccacg gcttgggaga acccagcaca 73020 gtaggaaaga tcagaccaca gtttttcacc tgtagaattc agcttggcgg tggcaggaag 73080 tgccagacca gccagcacaa ccgcgatgat taaacgtttc atggtgattc tccttatttc 73140 attggataaa atgatagggc tgtcaccatg ttgagtaaag ggtttcaata aactatcgta 73200 ttcagatcag tatcgactat cactgaccgt tctgtatcgc acaccctgaa attgtttggc 73260 gagttttacg aattccatcg ctggcaaatc aactttgtag accttcatgc gctgtttgcc 73320 gtccatgttc aacgcagcga caaatcggtg agatccgtca acaacgtaat tgtcagaaga 73380 cacccaaact cgacccatag gtttcttatt tcggatttgc ttcataatct tccagacctt 73440 catcttgttg atttcgttct gggtaagacg aagcattttg atgggcactt gcgcagcatc 73500 tatagacacg ccgttgtctt caagatattt gtgaaaatct tcttgtttgt cggcatcgat 73560 ttgcggcata gaagaacgag aaagcccgag gttcccaaca ggaatcctca ggccatttat 73620 gatattcatc cagtcaataa aggatgtaag gaacatgaca cacctcggga tatagggtta 73680 tcccttagtt agttcatcca cctatctttt cttctcgatt cttgtcgttc cctccgctta 73740 tgttcaaacc ggaataacag atagaagaaa ttaccaccca atacgaagat gactccgatt 73800 atcaccagga taccctttac aatttcccaa attaattcat tatccaaagt tacacctcat 73860 ctttattaat tccatcgatt aagacacgag cggaatcaaa atcttccccg ctagtattca 73920 gcatcttagt caaatcatcg atttcgtgaa ctggaccaag atcagattct cgcaaaatga 73980 aacccagaat cccattcaac gcggaagtga tatctccctt gtcgatatca tttttgatca 74040 ccataagttt tacaacagaa ttagtctgac gggaatccag atttaatttg tttgacacca 74100 tgatgttcaa tttgttacgg attattcttt gcataatata gcctcttcaa aattggaatg 74160 tttgtttcat aacgttcacc atgtaggatg aatctactgg tgttctgtta tacgtgatct 74220 tgcccatgcc attcagacgt tcgacaatgc gctcggcatt ctcttctact gcggcctggg 74280 tcggttggta atcgttcaaa tagatcgcga gttcctgtcg attgtcggac gtcacctgat 74340 tgcggagcga aggatagttg acaacatacc cacgagaaat cagttcggca acaagctgat 74400 cgtaacgctc gatcagataa atgagtttgt cgcggaagaa cagcacatga ccttcgttga 74460 gtttgtactg ctttggagcg cccttgagat tacggcgttt tccattcacc acgttaagga 74520 caacaggcgc aagttcttta tactcggcaa ggaggtgttg gtcgcaaaga gattcaacgg 74580 gaataacatt gatgcgagtc atggtatagt tcctgcattt caaatcgacg gagtaatcat 74640 accccgccat aatttataga attaattgat atgcttcaaa agagcgaaaa gaatattcgc 74700 cttggcttta accttaccga cgacacccgt ttcggcatca acctcttcag caacccatac 74760 ttttcctttc ttgctaatga taacatctcg gcgcgaagca tagacttcct tagtcatgta 74820 cacacggcgg aatcctttag cgcggagcaa gccccaattg cggtctattt ctactgccgt 74880 ttctactttc ttgtttgaca tgttataatc aacctattca atttctgacc aaccccacgt 74940 tagccagtta ttgaataata cggcaaatgt ttattcaagt aaagcctttg aaagtaaaaa 75000 tccccaataa ttattgggga tttcatggat tattatttgc agagaacaac gacgagttca 75060 gctaactctc cgagggtagg atcatctcca tgtttaccca cccactcgtc actaatttct 75120 acatcgtact cttcttcgat ttccatgacc agctcaatca tgtcaagatc gtcaccgccg 75180 agatcattct taacccgtaa cggcgctaaa gcatcgatgt tgtcgtcgat attatcgaac 75240 ttttctttat ggtcaccgtc gcgccaagtt tccatgttca ggttgtcaca agcgtactga 75300 gccagaacac gcattacttc aacataagtt ggtttgtttg acataagcat atctcaaaat 75360 gaaggcgggt ttccccgcca gttgaattta gattttgact tctttttcag ccagttcggc 75420 agtgacggtg tatttcaccc catcaacttc cacatccata gtggattctt ccaaatccag 75480 gtcggtaaac caaccatggc ctgcaacaat cccataaact accttggaca gcgttttgtt 75540 cagggcgcgg acttcgttga tagctgcttt tgctgcgtct ccgatccaac tttcgatcag 75600 ctttttctga gtctcttccg gtacgctggt gatcatcggt gatttaacga atgcattgta 75660 ttcagccagg gcattagcga tcagctgatc agcgacattc agttttttac cgtccgtctg 75720 ttttttgata acagacgcga tgctcggcag tgaagatgcg cctttgattt tcacattcaa 75780 ttcacgactc atatagacat cggttgattc tacagaagaa gtcttcggtg aaaatccata 75840 gtcgcgaatg ccgtttgctg acaggaaatc agccgcttct ttgccatatt ttgaagccag 75900 accagtagcg ttgcctttac caaccagttc atcacggtag aatttcagaa ctttctgttt 75960 tgccttcaat gcttcacggc gcacattgtc tgcaaagaat tcagcagcac tgatattctt 76020 tgtcatggcg cggttaacca ttgggacact ttccagattt acaatgaaga cttccggccc 76080 accaaacaca tgaacaccca tggcagtcaa atcctgtgcc accttagccc gaacaatcgg 76140 agaatctgca gtgataggca ttgttttcag gttgatgata ccatccttga caatggtgta 76200 attgcgataa cgccaggttc ccagctcttc aggaagttca tatttcttct gtacaaactc 76260 aggcacaaca accgttccgt gttgaactgt ctgcacactg atgttaggac gttctgaatt 76320 atagaccaaa ttgctgatcg ggacaatccc tttatcatct gctggattga attcgggggt 76380 ccaatcttcg tgctcggcca gtttgagcgc cagggcttta cgctcttctt tagaagtcgc 76440 attcgcaatc tcttcggcca acttgtcttc ggtgtcatca actttctgta cagtaccgcg 76500 cccaatgctc ttgtaagaga atagcggatg cttggtgacg atagagacat ctgcttcagc 76560 cagatacgtc agaacatcaa caatggtggt ggcgtcttca gccggaacca tattataatc 76620 gatgccatca actcctcgca gagattcgtc tacgatagcc tgagtcagat cgactttgat 76680 gttggaatag tcctgcttgg tgaaacagtt gctgtattgt ttgatgaagc ggacgtcacc 76740 cgttttcttc agcgcagccc aaaccaaatc tgcgtccatg gtatacacgc cgtaaaatgc 76800 cagcacgtat gccgcttgga tgtctgccag attatccagc tggtcgatca tgttggggtt 76860 tacaacccac agctgagaaa cgctttcagg gatgctgacg tggccaatag ggtgctcttc 76920 atcaggatgc acagctaaaa cagtcgccac gccattttca acataaatgg catgggtata 76980 aaccagagga acatcgacta caactttcgg tgaagaagtt ttcagcacgt tttccaattc 77040 ggtctgatat tcattctgtc cttcggcgaa tacgtgggtc gcaccagaac gttctgccat 77100 tagccccagc agttcgcgat tacaatacca accgtattcg atgaaggtaa tgttatcaaa 77160 cgctttgggc agtacttcag cggcatccag gatttcatta gaacgccagc agttgtcata 77220 cccatcggtc atgaatgcca ggttgttaac ataaccaggt ttattcaggc taatggcagt 77280 ttccgcagcc aatttcagcg gctcaacaaa accagtacaa ccagaaggct tcaggaaacg 77340 gtcaattaga ttattgatct cactgagatc agttgcactg ttaatctgac gtccggcaaa 77400 taccgttccg aaatcaccgc gagatgaaaa gtaaaggatg ctcacagtat cttccggttt 77460 caccagggaa ggcaggttct ccttcagatg cttacggact tctggaagtg aacgatacat 77520 ggaaccggag atatccacaa cgattacatg gttagacggc gcgacggtcg caaccgcatt 77580 cttaaatgtt aatgattcaa tcatcgtttt gacctttttg ggctttggag tgtttggagt 77640 tcgcgtcggc gttctccagc atagtttcaa tgaaatcccg gttgttttcc atttgggcga 77700 ccagaacatc actgggacgg aatgaattgt caagacaatc aagtccggcg cgttttaatt 77760 tgttgtcggt catcaggctc tcgtgagtta tatttcccaa ctatttcaac atgggactat 77820 tatattacga caggcggtat tgatgccaat taatataata aaaatgcccg attgaatata 77880 accgggcatt atattattga caggttgaaa tattattcag agcttattta aaggagtcta 77940 caatggattt gaaaatataa tctttggagc gttgttgtac cgggagttct ccatacggaa 78000 ccatgcaagg gtgttgcttg gtctgagggt ctttgactgg gccatacacc catccctcag 78060 cctccttctc cgccatccag ctctcatgcg attcgctggg cttacgatca ccagtgagat 78120 ggaagataac acctttgcaa gcgctctcac gctgccaggc cggagattgt tcccaaggca 78180 gttgagagtc gtcaccaaca gacttgcagt atgcgcggtt ggcttcatga caaatcttgg 78240 cgatgcgcag aaccaatggc gaataagtga gatcgagttt ggagttggcg cacaggaaat 78300 cactaacagc cttacgagat ttggcgttgt gagagtcaac aacaagttcc atgtcatccg 78360 gcccacaaac gaaagacgcc aagaagcgct cgccattttc cgctctgaac atcacgtcct 78420 gaatcatcac attgaagccg aggtgatagg ccgggcagag ggcgctacgt tcaacagcgt 78480 attgatcgat ccggatctct gccgtttccg tggctttggc caacagatct tgttcaacaa 78540 gcgcccggta cgcctccagc tgccacagct ggtcgaaggt gttattgtag gaaatctctt 78600 tgcccagggc ttcatcgaag ttggccgggt ctatggatgt gctgggcttg gtgccgtgaa 78660 cgacgaagcc gttatccatc ttgaaatgac aagtgatagc ccggtgaccg ccgacttcgc 78720 ggtcttcgta aatcacctca gcgatatgtg acttcaggac ttcaggagtg agtttgatgc 78780 cagtacgagt tgtcatgtgt tatcctatga tatttgttta cagacctcca ctactttacg 78840 gcacatgacg atatcgaaca agccgatatg gcaatcgcgc ttcttgatcc ccagattatg 78900 agccagccag ctgtaagcat cactcctgct cctctgccca cttttccaga tagggtcaaa 78960 cgacctatga gcttcctgct tagcagcacg gagagcggca ttcgccatcc ttcccagagg 79020 ttgtctacca tccccatggg tatggcaacc cacacgagcg tcgcatggcg agcataccca 79080 gaacttcagt ttgtgtagat ctgggcgatg agggtagagt acatcaccac tgacgtattt 79140 ggcaggaagg ccgcagtaat cacagatgac aggtttcata ttctttgtcc aaaagaaacc 79200 ccgcacacgg cggggttgct taggccgagg ccgacagatt atttcaggag tttttccagt 79260 tcttcaacag agagaccttc cagttcctgc tgtttcttac gctggatcag ttccatgatc 79320 gcctggttat tcgctttgcg ttcggcggcg gttgcgcttt cgtcacgttc tttcagtttg 79380 acaccgatga tcgctttcac gatatcgaaa cgcagttgta actgagagtc gactgcgctt 79440 ttcacgccga tgaaatcttc ttcatcgctg gcggcttcct tcacctgacg gctgaggtct 79500 ttcgccagtt cgtttagggc attcaggttc agatcccaaa cctgctcaac agacagcaga 79560 cctttgttag agttgaaacg cagttttaaa cgggttgctt gatcaaacat ttcattgttc 79620 cttattacga atttgtggtc aaaatcaatt agaaaatgac ttttacagta cggttaaacg 79680 cgccggacac tttgacgaac acgtggttgc gttgcgtcgt cgagaatccc agaccggaca 79740 gttggttttc attcggctgg actttcattt tactacccaa catttcaaaa accttacgat 79800 gtttatccag ttctggcttc agatattcgt tgtagaaacc acgagtacct tcaggattag 79860 cacagccttc aagaatgaag aacacatgct tgttaccagt ttgctcccca tcccaatggt 79920 ttggtgaatt caggaccagc tgtactttct ggaaggtcgc agtcttgata ccccaaactt 79980 ctttagactt atcaacatta gccagttcgg acttaatgct aacgacttgt ttgtctttaa 80040 cagtcaggat gactgcagtg atacgcccct gatctttcag gccaggatgg ctgaaacgat 80100 gcgttgcgcc tttgtattct acttcgactt caaacccttc gtcgatcttt tcacgttgat 80160 tgtagttgtg gatttcgaaa cggtattcac catcgcgcag cttgctttca tctgtaaaga 80220 tgatattttc caccggagcg cggtttggat caataccatc cataccgttc atatcgatat 80280 ccagatgggc acctgtcata gagcgacgat cacggaagta cacgtgctcc atattgttaa 80340 agaacatatg cagatcgagg tcgtcgttat tgtgccacgc caaggaaacg cgcagatacc 80400 cgtcaacttt accgccagca gcctttacac gttctttaat ggaatcggtc acttcaccgt 80460 tgtaagacca ggagaacccg ttgttccact tgaacaggtt aggcgcatct gggttcgccg 80520 gagcaaccag ggacatcagg ttgctagtat gagaattctc tacaagcact tccattgaat 80580 gcgcttttgg cagaacattg ctcaggaaat catcaatgct gatctcttca actttttcca 80640 gggacttggt cggagttttc acttcggcgg ccagctgtgc aaacggatcc atcgctttct 80700 gagcagccag atctgcgaac agaacgttgt tgattgtcag atcatcgtaa accgcataac 80760 gacgcgccag tgagtcttcc aaacccagag caataacttc tttctgagcg ttttcgatca 80820 tggattttga aaccagcgct gtcggacgtt tgtagttcgc cggagcaact ttggattcaa 80880 acgatttaac agccttttcc agttccacgc cttcgctgat atctgtcagc agagtgccga 80940 taactgtgtt acggatgccg tgtggaacat gattgtttga acggtatcca gtatgccatg 81000 cccacagaga acgggctgat tcggggattt gttcatatgc ctttttggtt tcaacaaatc 81060 ccttcactgc tgctttgtgt tctgcgccgc gatacagaga attctggtca atcagttcca 81120 gaacgatttc agctgattcc agagtaattt cacgcagacc gcgttcaaac aattcaatag 81180 cctggcggat ttcacctttt ttcgaagcga ttgcgtccgg acgcagaaca tagctaccaa 81240 gtaattgggt atggaaatga ttgtaagtac ggattttgcc atcttcacca gattcgtgat 81300 tgtgagacag gccgacttta gcagaatcgt taaaataaac atcgacgatt gcgtgttgtt 81360 gacatacgcg gaaagagccg cagccaccac gtcatattca ttacccagat caatgttgtc 81420 ccagatagaa attacgttca gttctgaatc gatggtgaca acaccgccga tgttacggat 81480 gaattgttta cagcaggtgc aatcgtgttc agtacgttcg cggtacagcg ggttagtacc 81540 agcagggaaa gatgccagat acagatccca aagagcatct ttatcgatat tggtcatgaa 81600 cagaccagtt gcggacatcg ccagcacgtt gttattaact gccgttgcga agggtttgaa 81660 ttctgccatg gtatagtctt cctgtttcag ttcaaagtga gcgcccttat cggggcgcgt 81720 cgttaaagtg aggtcaatat atacgttgaa aaagttattg aagaacgaag taacgcgatt 81780 ctttattcag gtttcttcaa acgatctaat aaattgaccg atccgcgatt gaggacaatt 81840 tcatcgcatc gatttttgta tctcccgcct ccatcataac cgaccttgcc gcgtggcttt 81900 tcccctctct cgatagcctc aacacagcgg gtgtacttgc tcaattcaca gaacatgttc 81960 tccagctgca tgacgttcat gcactgatct tccggcgctt cggctgacca gaactgctct 82020 tggacataac catactgagc aaacaattga tactgatgat cacgaaccca gaatatgcat 82080 tcttcatgag tcatgccgtc cttatccagg aacatcaggt caatacccgc acggcaacct 82140 ggaccagcaa tagtgaaatg attctcactg aatggatact cagggatgta tgtgaagtcc 82200 acccagatct gatatgccag gaatggccca agcccttcaa tgtcgtcata catgcgctgg 82260 taaactttca gcggagagtc aagacgtaaa agatcattga agtaatcggg gtacttgttg 82320 acgaatgcct tcaaagagcg gatgacacgc attggcatgt acggctccca accctcaatc 82380 gtgtactccc caggattctc ttcaaccagc ttcttggcga ccttgtaatc caattcatcc 82440 acgacaccct ggccaacacg gtgtacctta accatcatcc caccgaagcg ctgctccttg 82500 tggttgacaa caagttcggg gaacgccaga cattgtttta gaccgcctgt gttgaatgca 82560 ttggtgaaga tcttaccacc ttcagattca aacttctgaa gacgggcgcg ggtctcgtcc 82620 aggttgattt tagcaaagtc tgaaatcgtc atagcgccct cgagcgccac cttgatcggg 82680 tcccagagat tgaacatgcg gaacagaaca cagttgaaca ttttgtcggc catgctcaga 82740 gcgtcgttct tgacgatatt attgatcagg ttaagagact gcctgtcgtg ctctctccgg 82800 acgttacaga acttgacctg ccgtagtatg ggattatccg tccaaggagc aggaagacgc 82860 tggacgtcct ttctcacgtg gatcttataa cgctcgctca tccattcgta tgcgagttgt 82920 ttatggaatg ggcttaacat gggatgtgca gatttaattt tagcttcccg aacaccgcaa 82980 tatgggatgt catatggttt atctttcatg gtatcctctc tagaatacaa aacagaggcc 83040 attatagcct ctgttgttta gtgaataacg gattatatta atcgaagcga gagaggtgtg 83100 tcacagtgtt ttgaacaggt gcgcacgcgt atacacgaac attagctccc cacaccccac 83160 acagcttagg catattggta tcgttaatga tatacgctgg cacataactt tcaatttggc 83220 cgttaacatc tacgggtcga gaagattttt caactgccat agaaagaatt acttccaacg 83280 tttttggaga taccaacgcc acgccgttca gatcatcaac aaatacctgt ccttcttcaa 83340 ttgccatgct ggcaacgatg tcattgatct gacgggaagg ggtattcgtc agcatatcag 83400 agaaatcagg ctctttgaac acagccatgt ttttcaggaa ttttcctttc ggatattctt 83460 tgccattcca catcacagtc tcattcactt tgatgcatgc ctgagggaat tcaccttcaa 83520 cgcgtaactg gccatctggg aaaccgcgtg aataataata ttccagtgcc ggaccgactt 83580 catcttctga gcgaataaat ttgctcatgt tggaggcata aacacgctgc aagcactcat 83640 cgccgttgaa accagcaatg tgtgccacgc cgtcattgac tgttgtgatg tcgccctgag 83700 cgtccaaaat ctggcgcata atgtctttga tgtcgacaac agcaggttct ttcaggactc 83760 gcggagatgc agtgaactca attttcacct cgtggtcgaa ataagccgct tccagtaatt 83820 cgcgggtctc ttccagaacc agtttggcct gattgcgaat tttaccgaag tcaggggctg 83880 taatatctcc agccgcatta ccaaaagcca aattcaatct cacgttttta ttaaatgtag 83940 ttgtcataat atagcgactc cagttattcg ctttttgccc gacttgggcg aatagtgtat 84000 tttggaacca atttccactc agaaacttgg tcatgtttta caactttgat ccgagacatg 84060 tcagccactt cggttatttg ttccggatgc aagatcttaa ccatattcca ttgctccaga 84120 agccgtataa tccgattcat acgcaggaca tcttcacgcg taaagccgtt gtagtgccca 84180 tctagcatga acaaatgctt gaaatgcacg atgtgatatc tgccaaattt atgcaggata 84240 tggcacgttt gatacaaggt gttaggctct tgacgagtgt taacccctat ccgactcagc 84300 gtttccttga tacccaggaa aatccctggt ttgtcttggt tcaattgaac ttcaaccata 84360 cagtcaacaa tgctggcctc atcgttgaca gctgaaagtt ttaagatgtc cagcgtatta 84420 cgcgccatga ctcatacccc tttaacaatt atttgaatta cttagccttg cgcggtttgg 84480 ctttttcgtt gctgttggaa cgttcgacct tcgccttgat ttcagccagg acttctttcg 84540 gcaggaatcg aacatattct gaagcctttt caggactgat gtaataatac tcagaaatca 84600 atttcacatc aggatccata gctcccttct tagaccactt gtcatagcga cgttttgccg 84660 gaatgctatg aaacgccagg ttccattgca tccaaggagt aatggcatgg aagcggttca 84720 tttgttcagc aaccacaagc gtgtctttac tctgagcaag gccgcgccga gtcatgaaag 84780 gatcaaaagc ctttctgatt tcggggtctt cggtcaacaa cagattctct ttggtgctat 84840 tcaacgcacc gaggtaatcg aacagtgacg gagcggccat aatattactt ccatttgatg 84900 ttgagcatga cgttagtcaa gaagtaaacg ccgtgtaacc agacgtcgcc gacggaacga 84960 tgttcgatct gagactgacc acagacgcat accagatcag ggattgactc gttttgaatc 85020 aaaggagtct tttccttgtt ctggggaacg cagaaatgga agaaacggga ataaaaatct 85080 tcagtgatgt agttttggtt gtcggtcacc cactgcttca tcccagccca atcattggtt 85140 tttaggaaat ccaccaacgc ttggaattcc cctgctttaa cctgtgccag agcgcgttca 85200 tcgattttac caaacgtggt ggcattatcc tgaagagttc ccataatttt gcgattatct 85260 gggaaatatg atttcacaat ggaagcaatt acaccagctt catacggaat gccttcctct 85320 gtcaggatag ttgcgcaacg acgcatgaat tgaagtttaa cttcatctgc ttccttttca 85380 gaccagataa aatcaatttc gcgacagcgg gaacgcagag gttcgttaac gcgctgtttc 85440 gcattagtcg tcaggatgaa ggagcagttt ttggagactt tctctacgat gcctttcagg 85500 gattcctgcg ccgccatgga aagtcgctca acttcatcga ggataacgac tttgcggcca 85560 ccgaaaacac tgacgccagt tgcgtattga ataacacggt cacggatgac atcaatgctg 85620 ttatccagtg acgcattgat catcaacggt ttgatacaac cgatttcgtt gcaaacagcc 85680 agagcagaag tagtcttgcc cgtaccaggc tgaggggaat agaacagcat tgaggggatg 85740 tttccattgc ctgatgtaac atagccatgg atttttgcac ggacgtctga agggaggacg 85800 atctcatcca gattgtcagg gcgatatttg ttttcccacg catattgatc tgtgacgata 85860 gtgatgttag acattgcagc ctctttagat aaaacgtttc aaagggcggg gaaacccccg 85920 ccaccgataa taaagcgccg aatcgttatt gattaatcca gctgcatgcc gacgtaatag 85980 ttgatggtgc cgtctgcgga ttggaagtta accagttgca tttcggcaca ggcgcggatc 86040 acgtagttgc cttcgatcat tttcaggttg accacatcaa caggcatagc aaaatcaccc 86100 agagttgttt cacccaactc aacagtgtaa tcgttggaat tgtcgatagt agtggtcgtg 86160 cccaccagac gagttttacc gccgctggca accagacgta cagttttgtg gcccagagta 86220 gaacaggcgc gggtcagctc tttcattttt tcaggagtga ctgttgcttc aaattctaca 86280 gacggaagat cgatgctgtc tgccggaacg acagtcagtt ctttagcgga acgccagaat 86340 tgcagttggg agttttcacc tttcagcaaa atgtggtctt ccgacatttc aattttaccg 86400 cctttaaaac tcggcagacg ctggattgcc agcaatttgg tcagatccag aatcgggaat 86460 tcgaacggga agtcttcgtc gatgtcggca atagcgataa ctgtactgga atcgttaaca 86520 gtgcgcaact ttttaccagg tgccaaaacg atagaggggc agatggtttc aaagttagcc 86580 agcagttgta aagtgcgttc ggagagagtg atctcttgca ttagttgtat cctcaaaata 86640 tagtggggtt caagtcatat ttgacgcaaa ttagtatcgc gtgtttgtag ttatagaaca 86700 agtgataaat tgccctacgc gcgataaata aatgcctgac ggcatttata atattctgtt 86760 ttaataaaac ctttctttat cagtctactc gcttcgctcg tgataatact cgttgctcgc 86820 aaagctcaca actcgtatat tacgcacgga ttgttcaaca agaaagcgat ttttattcaa 86880 caattaaaat attttatttg gtctaaacag agcatgacat tattatgtag ccaagtttgc 86940 taacacgcga gaaatacata tgaagcaatt tgttggttta tacgcagtag gggaagacca 87000 agaagcaatt ctttccatat cagaacaacg ttcgtcatta aaaggcgttt atttacaaag 87060 ccttttctgt acatcggggt ttgttgtgac accgatgatg gtgataccat tactcccaaa 87120 taacaaaggt ctgtatgttg gcattattca acaaggccag gcgcgggaag tgaaagttgt 87180 tccattgctg gcatctaatg aagaattgtt ttctcagatt cttgagccga aagtgctaca 87240 acaatgtatt ggcacgatcg actgtttatt tggttccaac aaagaaggcg aggcaacccc 87300 cgcctatgtg aatcaagata tttgaaatgg ttagagcgcc acttttttca ttttaacagg 87360 gtggcgctcc ataagataaa atttatatct ctcatgagaa tgcctgagag catggttgta 87420 ggaaccgttg tagcgcaggt tgtctaccag gtcccagatt cgcgcaacat ccttagagga 87480 atgctggcgc atcaaacgcc ccaatgtctg tataacacgg atataagatt tgctgggatg 87540 ggccaatatc agatgatgga gttttttgat agatacgccc tgttgcatag taccatatga 87600 tgccaacagt gttatatctt ccccttcttc catagcagcc tgaatctgtt tacgaacttc 87660 tgtcttgact tccccgttga tgacgaatac gtttttcttg actgccgata gcatttcata 87720 aaccaacatc atgtgtgcat cgatacgttc gaacatgacc gccacgttcc ctttcaaaga 87780 cagagccatt cgggctatca attcattgcg gcgttcgtta gcaatgagaa attctatttc 87840 cttttgatac tcagcaccgt gcatttcaat acagtctgcc ataggatgta tgacttcaat 87900 catattaaca ttgatgtctg ccgcatatcc tagatcgatt aaatcgcgcg ctgtaataat 87960 tttatgatat gcgccaaagt gagcaacgac ttgtaaccct gcgacctttg tattcgccag 88020 ggttccggtt actcccaaac gttgatcagc gttaatacag ttgttcaaga tgtaagacaa 88080 tttatctgat tttgatgtat gtacttcgtc gacgacgata tctccaaatt gatggaacca 88140 ctctttgggt tggttctgga taccttgcca agttgaaata actatgggtt tgaaaatctc 88200 tttcgttgcc ccttcgtata ttgtctggac attcatcaat ggcttccatt ctgtcccgtg 88260 gctatattct tcgaagttgt catacaactg agtcaccaaa tgaatggatg gtacaacgat 88320 taacgtcctc agattacttt cgagggcatc tctgcgttgc ctgtagtaac gcgccatgat 88380 gtacaaaata aaggatttac cagcactcgt ggcagcttcg aggacacatc tactttgccg 88440 tattgctgtg gcaatagaat caaattgata ttcgcggaca atcgcttttt gatattgttt 88500 gttttcgtct cggtacactg cattcaatgt atcgatgaac gcatgaattt cttcatccgg 88560 aatatcttga atatatttta aggccggatc taatttgatg gtgtaaccgt tcatcttaca 88620 gaatttgaac acctcaaata acaggccgat gtcgataagc ccagaactct ttgtgaacag 88680 ccgcactacg ccgtcccatt tactgaacgg attcggttgg aaattaggat cttcaaattt 88740 gaagtaatcg ttgagttctt cacggatata atcctcggca aggatccgca ttctaacttc 88800 gttcactttg actatttgga tctcagacat cactaatttc ccccaatatt atggagtatt 88860 tagcgatccg cccagattcc tttctgttct ttatccattt tgtgatacag acggacacgg 88920 tcaaacattt tagaaataac gtctttgcga tcgaattcga ttatggtggg aacaagggca 88980 ttttcgttgg atataatatt gattaaacgc tctatcttga cattaaacat ttgttgaaac 89040 atgactgagt atagacacaa ttgaatacta taatcttcta tcatgcttcg agtttttagg 89100 gtgttggatg ttttgaaatc gattatgctt ggaattcctt cgtaaacccc gatgaggtca 89160 acacgaccag caagacccag gacttcgcta tataatggaa tctcttgtgc atatatcttg 89220 ctcattttgt taaggtaggg gaaaacctgt ttgaacataa acacgtattc ccctgcagct 89280 tccagaactt ctttcattgg tctgtttttg agatacaact cacaagccaa atgaagtttt 89340 tccccacggt ctgcgcaacg atgtgtttct atatcagcag cttcatgccc caacttgtcc 89400 cgccaggctt ctaaccatgt gtggtcacca gtacgcccta acatggtcgt cactgaagtc 89460 agtttgactc cagtgggaga aacatagtga cgaccatttt cggtagttac gcaagtcagt 89520 tccttaaacg gcaaggaata ttgctgaaat gtatgatgac gattttcaaa gtcattaagt 89580 ttgcgcaaag cctgtagaga aaccattaca tcccatccaa atattttcgc caatcaatag 89640 cattcttcac ttcatatccg agtttgttca aacgatctaa gcaactttcg atgaacttga 89700 ctttggcttt ctgctcttga agcatgctag acaattcgat ataatcatca tctgctttta 89760 cccatacgtc tatatcagat ttcaggggtc gaacttttaa tgggcgttca acataaacgt 89820 tgggcggcaa ttcccctgca taaaatcggc gtaaatagag atctatttgg cggaatttgc 89880 cagttagata ctccagatat cttccttcac gaatataatg gcgttgcaca gtcatccacg 89940 aacgaccaat tttcaatgac atttggtcta agttcatgtc ttcaggattt accgaaataa 90000 gaggttccaa ttctgccatt atatcttcgg ttttcatcgt ttcaagtttt gtttcgctca 90060 tgatttattc cctgctgttt caactctctg tattataact tattgtttat caatttcgcg 90120 ggtgacgcga gtcggagtca gtttcaaata tttgaacgtg acagtcgtga ccagttgggg 90180 aaccgcagca tccacatcca ccaatacgtt gtccaaagct gtgggacggg cttcttccaa 90240 caacaattgt agaccaacag gtcgattcat gttatcaaga aggtcgatgg tgatgtcgcg 90300 gctgacagct aaatcagatc cagcattgga cgcaatccaa ttgtaaatct gttcccagtt 90360 gtaccaactc tcatcgataa cgaacgtaaa tacgatgggg tcatacgtga gacgttctga 90420 aggtatggag ttgagcacat cgccagggga tggtccctcg ataccttcag aatacactcc 90480 aggaatactg aagtcatgta ttgaacgagt gagcaatatt aggtctccga tagttaagcg 90540 ccatttatcg gaagccgcga aattaggatt ttcgtttttg aattgtacac ctgtcatgtt 90600 agcacctttg ctgtggagaa cgttttagtg ttcctgatac gcggattcag aaaatggatc 90660 atgacgatga caatggtgct tgcactcaca agttgccgta tctttgtcac gtccgtcatt 90720 tctgtaaccg acctctggga tcctgaaatc agaaccatac ctgttaacat ctcagccgac 90780 attgataaat gcaataaaaa tattctggat caagtagtat ctgattttca gaatttccag 90840 actcttcaag ctgttggttg ttttgatgat aacaaccagt cactgagacc atactggaaa 90900 accacgattc ccctattgag gaaaggtgac gaaggaaaga tcccatatct atccgcaagt 90960 atttattact ctcagaataa tagcatcata gcgactttca acccttcttt ctttgacaaa 91020 ctcagaagga atactcaagc aagggacgta gaaatcacca gagacgttgc aatatcattt 91080 cagatagtta ataacaccaa atctccgata cgaattgcca ctcagggtgt tttcgttaat 91140 ggatctgctg tgggtaatga aatgaacatc tatgaaataa gaccaggcgg taaagtatgg 91200 attcgaatga gtgatgttgg ggtgaactcc ctggtgatgg aaggtatcga accagtggga 91260 gttctccccg ctagacattg attatttcag ggactctttt aattctggag tccctatttt 91320 atcaataacg cctccagcac agagatcttt agcccattct ccaagaacat tcgcaaaaga 91380 gaagtttaga cattctttga tcatactttc aatatgagca agttctgcag ctatcccatc 91440 ggtgatatcg tttataactc cattgacggc ggttattgcc tcattgatat gtcctgttac 91500 ttcagcagcc aattgctgta gttttgccat cccttctgag gcaccttcca taatcatgtc 91560 atacaattcc gatatcttgt ttgttacggt ctgtagagca ccttccatag cattcagcca 91620 ttggcgtcct aaatcctgaa caacaccaaa agccttgttg atcaaatcac aattgtttgg 91680 ctctcgtgat atacccttca gacctgattt gtatgacacg gaagtaccga tgcgagaata 91740 cgcgtcattg atactttggt cgccatatgt gttcagtgtc gttatccccg tgttggcggt 91800 gctatacatg gtggtggctg ctgtgagttt ttctggtgtt agtccaccag caaccatagc 91860 cgcctgcatc tccggagtcg cgttggcagt tatcaatggt atattggtac taccactggt 91920 gattaaatcc tgtgagggac cggagaggga cggaagcggg ttgctaaatg cgttaccaga 91980 ggaaaggaca tcgtagattt gtgcgttcat aaataccccc aattttgggg gtatttataa 92040 tcacggaaga tgatagataa aattctcgca gaactttttg gtgtatttct ttagaaatat 92100 aaatttaggt tcgcgtggtg tatctttcag atcatttagt gtgatataac tgattcgcgc 92160 cagaaagtac atggtaaaag cgacacaaag aatcaaaatt aattgcagca tagctaactc 92220 catatgggtg tgaaggcaaa catatttata acaatcgttt ggttttgggt ttgcccatga 92280 gagtgatatt gacattgaca cctgcttttt tcatgcgggt aatcatgtct tgcgtcccag 92340 tagacgaacc atcccataac gcaattccaa agacctcaag acctttttgt ttggccaggg 92400 tcatagcttt gtctaacata tctttgttac gttggtttcc tgcacctttc ccatatatcg 92460 tgtgataatc cttagggatc cccattggcg taacatggac ataattgatt tcacaccaat 92520 cacgagatat caagtccaca ccaaccgctt caccttctat aaaagtttcg atctcgtggg 92580 gatctaacag ttcatccagt ttggcgaaga ttttatcccg ctcggttatt gagcgggaac 92640 ctgtaatgag cacgacatat ttcttcatag aactcacagc gccccaagat tgctgatgac 92700 gtacaggctg cacaagggag tccctgatga acgaggttct atgctcattc ccgagaggcg 92760 gatcagttcc agcaaaccgt cggtggtctg atacgcacga gtcgaaccgt ttggacgata 92820 tagctccaac tcggttcgcc cttcctttaa tgcgttacgg atgcgtgtga atacgctgtg 92880 ggcttgatat ttttgacgta gaatatctaa acgggtgatg agatttcggc tgcggctgcg 92940 acgtcccgtt gacgaaacaa ctaatttcat ttctggtgtt ttacaagcca tgttatagtc 93000 ctctatttgt aggggttggg tatgatttta acatacccgt tcaaatgttt tagaacaaat 93060 tacagatctt ggcactgatc gcaatattcg tcgtatgtga atgtctcatc acacaggccg 93120 tcacgcatca tatcggcctt ggcttcgcca aacattttca gggtgataac gttgccgtct 93180 aaatctttac gaagttcgtt cggcttggtt tctatgaagt cgaacaccac aaagaaccct 93240 tcggtgacat atttgatggt tttgttgctc agcttacgaa tgccaccgtt ctttttgaag 93300 atagaggtgc ggaggttttc gaattcggcc agattgtcat cgtgattctt gatggcgttc 93360 agcattgcgt caaggtcgat ttcaggacga agcattttga cctgatcttc gcggtcataa 93420 gaagtgaaag attctatgtt ggtgatgccc agagcgtttt taacaaacgc gtcaaatttg 93480 gtgaaattgt tgaatgccca gacggagatt tttacggttg tcatgactga tactcctgtt 93540 gtaagaaagt tatatcgtac aacaggaatt gttattgaac tattcgcgta ttaaatcgtt 93600 acgataaaca atcacgtatt ttgagaaaca tatttcagat atgcgtattt gtaaccttcc 93660 tcggtgagta cacacagatg tgtatctcga ccttttggta cgtttttaac atcaactcgt 93720 ttacaaaacc ccagggaggc caattcggct tctccagatt tagcaggtat ttccccagct 93780 tcacgaggtc caaaccagaa aagaacgaat agagtatcga ctgcaccgcc agataattga 93840 tgagacattt taacctcctt tgataaatga ggctttatta tcttacatat ccctataaag 93900 aaaaaccccg ccgaagcggg gtttgttatc aaaacctgtc gattagaaca gagatttgat 93960 caagcccttc ctgaagtaag ggttgctgtc ttgagcaata ccgtcagcag tcacgtaaac 94020 ctgcgggtct tggttagccg gaatctgtac gaacgggtta gcacagatgc cgtaacgggt 94080 tttgaacgcc atacgcggag cgaaggtggt ttcaccctgg gtgcggtaca tttccagcgg 94140 cacatacggc gcgaagaaga taccggcatc cagcgcagtt gcgcctttgt atgccagggt 94200 gatatattct gctacagcat acgggtcaac atagacgcgc ataccgttgg acagaacacc 94260 agcgaatgtc tggccagtcg ggtcaacagc cagtttagtg ttttcctgca gaaccggagc 94320 atagtccagc atgccagaca tcgccagagc ggatgccacg ttcggagaac acagaacacg 94380 gttgccttta ccacgacggg tgtcaacacc gataccgttc gcttcaactt ccagcatgaa 94440 agtcaggaac ttccattttt ccagcgccca acgaccggag atgtcctgcg cgatatcaac 94500 aacaccgttg gtgccgaatt ttttgaagcg aacagcactg aagttcatgg tacggatgaa 94560 ttcacggttc atttccgcct gaatttcagt taccatcacg tcagacagga tattatccac 94620 gtcttcgccg tgaatcgcca tcatgtcctg acgcagttcg tggctgtaat cagcgtacag 94680 gccgcgagac ttggcagtaa cggtcgcttt ctgaacagtg ataccaacac gcgcccaagg 94740 gttggtggta gtacccagca gttcagcgtc acttgacggc atacctttac cgatagtggt 94800 cacgccagag ccagaacctt cgatttcagc ctgactaaag ccagacgggt cgccagcctg 94860 tacagtacca tcaccggaat agccggaatc ggcttcctgc atgaacagtt ctttacgaga 94920 ctgtgcggtg ttggaactgt cgccaacgcc ctggcgagcg cgcagtgcaa agatctgacc 94980 gtcaggacca gacagcggct gaacaccgaa gaagtccatc gcgatgttga tcggcgccag 95040 acgttttgcc atgtcgatca gaactggctg ccatttaccg acagtgctgt tcacagaacc 95100 aggtgcgtca gattcgccca ggttttttgc gttccattca gcctggttct gcatcagacg 95160 gatggttacg ttttcggcag acagaggttg aatagcttca gattcttttt ggagaactgg 95220 cagccactgt ttgcgcattt cttcggttac aagtttctta gtcatgatgc tcgttcctta 95280 cattgatatt cagttaagtt gaaattactt agtagttcaa aatcaagccc cctttcgagg 95340 gctgtggctg ctaaaattag ccgttcagca aagcactgat ctggcgacgg acggcttcgt 95400 tgacttcttt gccaacttcg tctttgtcat catcgtcatc gtcatcatcg tcgtcttcac 95460 cttctttctt cggtttttta ccttctttga tgtctttttc agacttgtcg ccatccggct 95520 tgcctttttc attgtctttg ccgactttat cagagaagtc atctttgcct tctaccaggt 95580 tacggaaggt gcgcacacgg gattcaaatt cagactcagt ctggaattca ataccttcca 95640 gcaggttgac aacagtgtct ttcttggtgt caaccatacc ttcacaaata cgatcaatga 95700 catcattgcg ctggcgtttg gtttcacttt ctttgagctg agccaattca gtattggcaa 95760 tgctggcgcg tttctctgct tcagccaggc ggttggtgag agctgcaatc tgaccgtctg 95820 ggtcagtggc gaaactaaca cctgcttctt tcagaacatt agagaaacca gtgaggaagc 95880 gttcagcagc ttcggttttg atctgagcgt caatagctgg ggcatttttg ttagcccatt 95940 cttcaacaac cgcgttgagg aacgaatcaa ctttttccgc caactgaaga gtgaaatttt 96000 ctttaaggtc tgcgacttct ttctggtgag cttctaccag agtcaggcgc tcaacgttac 96060 cagccgcttc agtttcttga atagcttgca gacgggcggc ttcaacttta gattccagca 96120 gaccagatac tttgtccaag aaatcggtgc tgaggccatt aacgccttca aacagttttt 96180 gcaattcagg tttcatgata gtttccttct gaacgatttt tcagtattta gtgagctgaa 96240 attcagccca gatgattcaa tgctgcatca aggcggcgca ggaaatcgtc ttcaacctgg 96300 atattggttt tcaccaactg gtctacaact ttccctttaa catcacgagg catccaaata 96360 cccgaagcct catcaagctg ccattcaaca gattcactca cagccttaac ataacaaact 96420 tgtccagaag gacggtcgac tgcatcaaca gcggtgagca taaagccagg ctgaacgtca 96480 tcataaccgt ttactgactt ggtctcaccc aggccacgtg tagacacggc cagattgaag 96540 tctgcttcag ccaatgcacg tatgatttgg ccttttggtg tatttaaaat tcgcgcccga 96600 ccgatggcat tagtgccttc ccagcgaagg gattcggttt tgagcgctgc ttccaccaga 96660 ttagggaaag gatagtcagg atgtgtgact tcaccgattg cgcgacgatc ttggatatac 96720 tctttgtcgt atgcttcgac agcaggaata cccactttct gcagatcata gttacgcccg 96780 ttacggttga cttggttaca catcacaaac ggaccttcga tgaacatggc cttcccacca 96840 gttgaggttg tggcctcacc gatttgaaga tccttcccta tcgctgtgat ctcacgcaac 96900 agtttcatca taaactcctt acttgttctt actcagtccc atcattttgc ggaacttcat 96960 agcctttttc ttgcggcgct cgattttacg ttgatagccc attcccatac gctttttaga 97020 gcggagggct ttgcggttgc cgatcttgcg aacacgacgt tcgctggcat ccatgacttc 97080 acaacgtgaa ccatcagccg acaatttgaa cccaggggca catttcaagc ggcggcggcg 97140 tttaccacga gcgttcactt tatcgatgac tcgctgctcg tccatacgag aggccaggaa 97200 atcagcgaac gtggcgatct ctgtgatttc catcatgcat ctccttactg gccgttgttg 97260 tttgaattca tatcagctgc gatagaatcc agaacatatg ctgtgccttg gtttaatagt 97320 tcttgactac gtgcatcaag ttccatgttg cattctgcaa cagcagtttc agtgtcaccg 97380 tcaattactg cacgaacgat atcaattgcg ctcatgattt tgatctccga attaattttc 97440 tatatttagt tgaactttaa atactatcgt ctgttgaacc ggagaatggg atagtctcag 97500 gtttaaactt caacggacta acatctgaac cgctataatt gccagtttca tctgcttgaa 97560 ccttcggata gagacctttc ttcttctctt ccgcgatctt cgtttgttgt tctttaactt 97620 cttcatcaga catacgcaat acatttctca tgacgtagtc tatggagaaa atggaaccaa 97680 cgaatggctc aacagtgttc aatgaagcca gacgatcatt caagatagcg ttttcttgtt 97740 gttcacgaat gtaactatcg gatgtgaatt caaactttat aaacggtttg atcttctcat 97800 tccaatcctt ttcatccgta acgcctttca aaattaactg gcggcgcaag aattccataa 97860 agaaatggga gtaacggcgt cgtaacccag cacagaactt gctgaagcgc agctcttcct 97920 gtgtaatctc cgcaaggtta gaacccccaa tgttaataga tccttcctct tggaggcggc 97980 tcttagggat cattagagca tcatagagtt tttcacggaa atagttcacg tgatccattt 98040 cgcccaattg attcccaccc ccaacagtcg caatctctgt agcattctga ccttcgcggc 98100 gcggcaacca ataatcctct gcaataccca taagatgggc attacctgtt atcttaccag 98160 tggtgcggtc atatgcgttg cggtttttga atttacccat catcatggtc atgtattctt 98220 cagcagattt cttaccgaga gtaccgacgt caagatagaa tgcgcgtttc tcaggggcgc 98280 gagtgatggc ataaattact gttgcgtctt cagtcgtaac caagttgttc aacgggcgga 98340 ttgcaggatt taaaagccct gggacaatac cgttagccaa tggttcttca ccactatcga 98400 tataaacgat actttcgtca tcaaacacga gttcttgttg tgaaggttgg aagttttgag 98460 aagtacctga ttgaccagtg aattggttcc ggttgtaatt cggattgtaa tagtatttca 98520 gcgttacaga ttcgatcgct tctataccac cttcacgcat tgccttttca acgatgtaca 98580 caggacgaat acaacgagaa tccagcataa ccaatttctt gatcccgcct tttttattcg 98640 tgggatcaac gatgacatga tatgcttgtc gaccgtcaac ataccatttc cggatcttct 98700 gatatgctgt attgtcaaag tccatcaagt gcataacttc tttgaagcat tcggtgatag 98760 attctttaac agaatcagat atcccttcaa ctttgtcaag gtttactgtc actggagttt 98820 catcttcctc acaggtgaca acatcattga caataatgtc caccgctttg cgaatttcag 98880 gctgttgagc catggactga tattcttcca caactgtttt aacgctgaga agttcacttt 98940 caacgccaac atagttgtag gtgttcgcac caccctgaag gattatagaa ccgtcttgag 99000 cgtcgtccag agcaacaact gtcgctttgg tgagcaaccg ttcatcttgt ttttgggcta 99060 acttatcggt gtcgacttta gcgttcacca aaccgccgcc gccaaacaaa ccgaagaacc 99120 ctctgccgta tccagccatg atctaagtcc tcaacatttt cttgtaatta gtgaggggga 99180 ataacattcc cccagcaccg aggacattac aatgacttgt cagaaacggc ttggaaataa 99240 cgcaagtcga cagtgaactg tgtgtaagag tccattgccg acatatcgag ttccaattgg 99300 ccgaggtttt gaggccagcc accctgcaaa gtccatgtct tagtcacgtt gtcattcgcg 99360 tccagaagtt ccatgatgat atcacggaaa taatcatctg gattcgcgct ggcgcggttg 99420 ttttcactac cgttgatgaa ttgctgccac acttcaaaag cattgtatgg agcgttgttc 99480 accacgttaa tgaacgtcac aggaagcgct tcgaaacgac gatcccctgg gaacggaagt 99540 tcacgaccac cccagggcac cagaatttcg cccagttgac ctgttggggt gttggtggtt 99600 acagccagca aggacacgtc acgaattgtg tcggaaccag caacaaaaga aggaaagttt 99660 acagtcacac gccagcggtg ttggcgttgt acgccgcccc ctcgtgacat ggctgcgcga 99720 aactcattga ctgtcgccat ttttatatct ccaaataaga gtacacaatt ctaattagtc 99780 gtcaatcttt taatcttcat ggaagaaaaa tcaaatccgt ggtcaacatt gcttaaaacg 99840 ggttcgattt cacacaattc ccaacgggga tctatgagag aaacaagacc aatgtgttca 99900 cctgtggatg tcaattttgc tgcagtttta cccagcatat gacttccatc attaccgcct 99960 ttattcatgt tgtaacccat ctcataagaa ttatattgag cgatgagttg cttctctaat 100020 tcccatttat ggacttcatc ggtctgagca attacaacga aagtaaatcc agatgttcca 100080 tacttacgca tggcatcata caattcactt tggactccat gatgaaaagc attcgcaaaa 100140 tgctgatcat atcttcgttg tgggtgattg gtcacaccga tgtagacctt tccattagtt 100200 atcgtttcaa ttttgtatgc gtatatcatt caataactca aatcaataag acaaaggaaa 100260 accccgccga agcggggttg gtcattttat gaagcagcaa cgatgccgcc accggattcg 100320 atttcgctga actccatatc tggtcgaact gcagcaaagt caagatacac ccaatttatg 100380 ctgtactcgg gcttcaacca aatgccagca accatttggt tcgctgcaat gacatcagca 100440 gtgttgttgt cttcatcaca tttgacttta ccatcgtaaa tcgcacccat atttgccagt 100500 tggcgaatat aaggacgaac cgcattgctg aacagactac gtgtaaacgc gtcattgttc 100560 tcaccaagat agtatttggc gattgcggcg atgttctgct cagccatgat gaacaggcca 100620 cgaacgttga tgcggtcaaa cgccgacggg cgggtcaggc cagttttgtc accatacagg 100680 acgatgcctt cattggagaa ggttacgatg ctgttgatct gattgcggta caacacagca 100740 cgttcatcag aagacgcaga ccacgccatt cgattatagt tgttatattt accacggttg 100800 tggaacgccg gagatttgta gatacccgcg atttcaatgc ttcgcgccca aacacctgcg 100860 gtgccaccac aagccggaat ccaacgcatt ttgtcgttgt acttgtcgta cacatatgcc 100920 cagttatcat ccatgaagaa ataagaagag tcgcgaacaa ggctttcacg ccaagcaacg 100980 acatcatcca tttcacgacc acggttgcca acaaccgtat cacggagcgg ggatacgaaa 101040 gatacagtat cttttcgctc agtagataag tcgatcaatg cttgttgctc aatcagttct 101100 tcacagtacg caaatactgg cttcgcatca tatgcttcag cattgttcaa gacttggata 101160 gctgccacgc ggttgatgtt ataatcgtct acgccgcctt ctaattcaac gacacctgca 101220 accagttcgc tcgcgaaggt atacacccaa tttgaagtat cgttgatcac gtctttgaag 101280 tacgcattcg cgccatcgga ttttttagaa ccctgggtgt tctgcatcag ttcgtatttt 101340 tcaatgatgg aaccagaagc gccaacagta gtgattacgg ctgttgcagt cagtccttta 101400 tcatcaggaa cgatagctgt aacggcctga ggaccgatag ctttatgtgt cacgatgaca 101460 gtgttggact tcacgacaac agaagaataa acacttgtca gggaagttag cgctgtgccg 101520 attttggttg ccaaagtggc tggagtatca gtatccagat atgcgatatc ttcacctgcc 101580 acactgatgg tgccagcagc agtagccgta ccagaaacgg agatacggtc aacctgaccg 101640 accgcgccag cagagtcggt aatgcgacca actttgtcta cgacaactac atggaattca 101700 ccagactgag gtgcgtatgc aaagttatta cggaattccc aagttgagaa cccagcagca 101760 tcacaaacat tgatagcaat atcattaccc agggaacctg gataacgacc agtccaagtg 101820 atggacgccg aaggacttgc tgtttcaaaa tccagtttgt ttttgatcgc aatcgctgtc 101880 tgacctttgg taacagagtt cttggccaga ggaccaacaa cacgggtcac ccatgccata 101940 gagctgtaag acaaaaagtc cgcgattacg agaaaatcgg tcgcagtact gtcgttgggt 102000 ttgaagaatt tcttcaccaa acctgtctca ccaccagtca ccagcactgg aagttcaact 102060 tcaccccatt gaaatttgcc gacggtcgcg ccctgaacaa caacggacgg ggacgtctga 102120 agcgtggcat cacgctcagt ccactgaacg gacggcgcaa cgctgaagct ttgagttgcc 102180 ataatatcat tccttctcgg tagagtttcg ctcaatttga aagatattta gtgatcaatt 102240 cttaaaccac tcatccatgg tcatccctga catttcgttg aaaacttgaa tgcccccgaa 102300 accaggcaaa tgctcagttt cggatggggt gtctccaacg actaaaccac caaatgggaa 102360 tacctgctga gattcagttg aagacattcg gtttctcatg tcctgagaaa tacttgtaga 102420 tgtcaaatca ctgaaccatt cttgttttac cgcccatgaa tataagacca acggcatgac 102480 acagtcatcg tgacaaccgt catcggcttc ataccgagcg cctttgaaca caaatgtact 102540 gagttcatct atcgtgtcct ggtcttctat caccaacatt tctttctcaa tgagcgcttt 102600 caggttagca caaccgatag atcggacttt tctgttggta ttgataccag gttccggttt 102660 acgtccacca atccgtttcc ccgtcccttt gttatctgtt gatgtgaata tgatttctgg 102720 atattctatc tcttgataca agatcgtgat aacctgaccg ccgacgtcgt tgtttgtttc 102780 aacaaggaca ggacattccc cgtattcggt gcacatatca gctatcgtgt atgcatacat 102840 cataggaggt atcgtattat tcctgtactt ggctgctatg acatgcggat attcagttat 102900 atccagaatt gttaagacgg aataatctcc ttccaccccc ttcccagtgt ccgcaatccc 102960 aaagtagaga cgttgtgggt cgtattcctt ataaatcttg gtgaattcat taggttcccg 103020 atacaacttg gacgtcattt tatctaagca tttggccgga atcaatgaac ccacggaacc 103080 acggaactta atgccaaatt cttgatcgaa acgagcatcc cccagacggg cacgttgttt 103140 ggtttcccaa tctggatctt tggtatatgc cggaacctta taccatggga cttcagttag 103200 gtggaagtcg ttgtattgtg gatggcgcgg atctgctttg gtgacaatat catagaacaa 103260 ccctcgctgg cctttcggag tacttgtcaa aatacagcgt gatgtatcgg cagatgcaat 103320 ggctgggaaa gttgattccc aaaattcaaa gtcattttcg atgaacgcta cttcgtccac 103380 gtacaagaga gatacagaac gaccacgaat agagtccgaa gacgttgcat aagcatatat 103440 cttagaacca ttctcaaact ctatcagggt agaaccaaac ttctcacaac cctgctgaag 103500 gaagaatgga aggtcttggt atgcctttct gatacggtca agaatttcta tcgcttgttt 103560 ctctttgttg gccagtactg caatttcctt atcagaatgg aacatcgcat accaaagaag 103620 aaacgccgcc accacggtcg tgttatgact gagaaagcca ttcgtgtaat aacgttgatc 103680 gctggacttg acttgcaagt catacatgtg gtggtactca ccagtctccc agatctcaga 103740 gatgaattct attccctcct gggtcattat ggcatctccg gcctccatgt ctttagcaaa 103800 tacttcgcgc ccatattcat tgaagaacat gtgctcatct gcgacatgaa ttgtgcgtcc 103860 ggtttcagtc ctgacaacgt attcagcgta ttctttcgtt ttatgagcgg caataaccgg 103920 aacccagcca gtgtcggact caacaaaata tcgtttcccg aaacggctgt ctacaaactt 103980 attgtggttg ccaatggtat tcagtggcac agcatggttc ggtccttcga agcgcttgtg 104040 aagctcttct atggtgagat gcaactcttg ttgactgatt gtatcataga cataaacaag 104100 agtatcacca cggacgcatt taccggactg acgagcctgg acgaccgcat tgaatcgata 104160 gtcctgaaag tcatggaaca attgtttctg ataatcatgc atatcgaaaa ggataaagcc 104220 tttatcgatc gtggttatct tgtaatagtt ggcggcgaag taatgcgcgt ccattgaaca 104280 ttcaacgaat tcgtcttctt gttcatctgt cagcattaac tcgactcgag gagcacgcac 104340 agaaggtttg cgcatgaacg tttggtccat acgcaatttc acatcgtcta ttttgaaccc 104400 cgttttaatt ggggcatatt ctatatcacg cttctgatac gccatcgtct tcttccttca 104460 cgtcaatcgt ttcaccgtcg ataatttcat cttcggtttg ttgggtggct tttgcctgag 104520 cgcgttcttc agcgcgacgg cgggcatctt caatcgtctt caataaatcg cgagaagatc 104580 gcgccttttt cccaaccgat actgttgttg ttccgtctgg tgaagttgta acatccactg 104640 tcgtgtcatc aacaggtggt tctttatcac ctgttactgc cttgatggtt ttctggtttt 104700 ccatcaagtc tttattcaga cctcgcatga gttcacccaa ttcacggaaa acagaaaatg 104760 ctcgcggagc ttctgtggat gcagccaatt tagcggcttg tcccatcatg aacattgtgg 104820 cttcttgcat ggcatatgtt gtgtcgcgta tccgtttgta atccgttgta gcatcagtgt 104880 ccgcaaactc aggtactttg gattccttgg aagcaatatc ctccaatgaa ggcggttcag 104940 gaatcggctg atacccttcc ggacgttcac caaaccattc acctgtattt tcatcgaagt 105000 caatacctgg acgaggggcg acagcctcca tcgcctcctt cccaacttcg tctcgggcgg 105060 tcactgcatc aagcgtggcg agtaaccttt ctgacatatt gctcatgatc aatcctccgg 105120 atgatgtatg ccgtctttat caactcggaa ccactcagga agttccgacc atggcatgtt 105180 caaatcatta gacatttcaa taattatctc tttgatgacg tttggatccc caccgcccga 105240 accatcatca acccaataat cttctccata gatgtgtcca tgtaattgaa aattaaaggt 105300 gcaatctata tggggtgatt ctgttgcgtc tccttcccag ttgtcagaaa tcgtgtgatt 105360 taccaacatt atcttcacgt tctgatcttg agataaagta tcgttgtctt ttatctgaca 105420 atcaatagaa ggagtgaaca cagaataaat ttgttccaac acctgtagca tttcgaccag 105480 tttcttcgtt ctgatgttat attcaaaatc tataatgatc ggaattcgtt gtttggaccg 105540 cgcagttgca gtcgatatct gattatgata cgacttggtc acctgtttat tgatttcgaa 105600 ctgaccaaag gacattgttg caaatggcag catattggct ggcacgttcc tgttgaggtc 105660 attacggcgg ccaatggcca tatgcagcgg gatttccatc aagccacgtt cggttttgac 105720 ttttaaatcc gacatgatag cgttgaaaac atggatatat ttcaacaacg attcatggta 105780 gaaatatttt tcaaatggtc tggccatgat tattccccga agtctatctt cattttattg 105840 ggcgaaagat ctttctctat ttcgcccgca aattggttat ctgtctgtag actggcatct 105900 ttatagacac catcgccgtc tagatcctgc aatcgtttat caatatcgtc tatttcagat 105960 acacctgtat cgaaatcttc gttaccgtat tggaacagcg tacatggtag agaatatgtg 106020 taccatttcc cgaattgcat gaattcttca tcgttgttag ggttattcac tttaaatatt 106080 ttgttagcca taggcagata tatcaaatca ccttcttgag gcatttgttc aaggcctgga 106140 ccattaccaa taacttctga aaaacgacga cgagcaatag tgaaggtcac ttcatcttgt 106200 aattggatac cgccgaactt ttcccacatc tgtgtgttga agccttgata atcctgcatg 106260 tacacttcga tgtcaaacgc ttggtcgaat ttgtgttcgg cctcgtttaa aattgggtat 106320 ttttcaacaa tagaacgtgg gatatacttg atgtcaatcc cacgcaattg tatcatctcg 106380 accaccaagt catcaattaa tttttgagta ccttggtgtg ctgtatagtt gaaatatttt 106440 gaagtagcca tgactttacc ctcaattttg aaggtattta gtcaatcatt aattcttttg 106500 aggaattgat aaatgaatgt tgaagatatt aaagaaactc gtgacggaag gcgtgtgaga 106560 attatctgtg tagatgctaa aatcgccgat ggttcatata acattgtggg tcttatcaaa 106620 gacgaaaagg gtaatgattt tattgaatgg tgggacgaaa agaacgtggt tgatggttat 106680 attctagcaa attcagatcc ttccggacgc gacatcaagt tataaaaaga aaggcgggtt 106740 atcccgcctt ctcttatccc atcataaaat cgatagggta ttgctgacca gtacgcaatt 106800 cttcctccaa ccgctctatc tcggtctcag cctcactgaa catactatca ccatccagtt 106860 cgataccacc agggagacgg atgcctcttg ccttcttaag cacctctgcc caacggcgct 106920 tgaccaatgc agtcgcatac gctttcaacc acatatcatt ccatgcttca gcgttttctt 106980 ccgattcggg gtcgatattt tgataacaac gaaaagccag agtttcatca acaatggcag 107040 caaactgcgg gtaaaggcgt cgctggaact tcttgtacac aaaattacgg cgaacattta 107100 agacgcttgt gatatccgac aggcgttgtt gcatggaaac ataatcaatg agacgaatag 107160 aaaccagcgc tgctttgggg acaagcattg cttgagccat ttgccattga ggagttgccc 107220 agtttccgat tgactcaata ggaggtccag ggataacttc aatcacatcg tcaatatcat 107280 cgggaaattc tatatatccc ttgtcgatat cttcttgttt aacttggtac aggaagaacg 107340 catcttggct accatcacga tgatattccc aaaatttctg cagagcatca tcgactgcat 107400 cttcgacttg tgaactgtca aggttaattt ggatcacggg agcgcccaat ttacgcaaga 107460 cataattcat aaaagatttt ttgtctcgaa tcttattgac ggccattgtt attccccttt 107520 tgctgcaaat cagatacagt aatccgcagt gtgcgaacat catctgaaag actgctgcta 107580 ttgagtttta actcagccat gttttgtttg acatatgcga ggtcagtatt catgatcgcc 107640 atacgttcac tcatgtcatt cactttctga agaacttgat ccatcttgtt ggaatctcgt 107700 tccaatacat tcacgcgcgt ttccatcccg cccatgaacc aaaggaacga tgctgccgag 107760 accaatgcag aagccacgac agcggttaag ataccacgga tgtcaagccc cgttctttca 107820 gcttgcgtcg ccattctgac ctccttcggg gatttcgatc cccaactttt cggccatcat 107880 tttgattgtc gcctccagat tagatatctg gtttgattgt tcaacaatgg tggcttcacg 107940 ggtttcattg cgttgacggg cttgcaatgc agccatgcca gcggcgtgat cggtgcaaat 108000 aatcgcgcca gggcaagaac tgcttctcaa catggatgcg tgcccctgta ctttcactcc 108060 acgcatatct ttatcctcta ttggtttggt gggctttacg cccacctttc aacattattt 108120 atgccagagc aataagacgg aagtctttga atgaaggagg agcaactcgg ttccccctta 108180 caagtgctct gacttttaat ccaacgaacg gattgttgct tgccacagtc ttgtcatact 108240 catattcaaa gaatgtggaa ccgtcgttaa ccaaaggcga agttggggcg acgtcttccc 108300 aagccacact atccatctct tgccctgctc gtagaagttt cacctgcacc ttcatcgaag 108360 actgagaagg cagcatcgcc ccgaagaaca gtttcacagt cgaacatggg ttatcgaaac 108420 caatgtcctt tgtgacatat ttgaaaacgt cttcaaaagg atctacacca taagagttga 108480 agatcacgct caggtcatca ccatcaatca tcggtgctgt gtacacgttg ttttcactac 108540 gagtcatagt agcacgaatc tggaagtcac caacctgacg atagatacct tcagtcggca 108600 atgccacgtc agtgtcagtt tcaaactcag cccaatcaga catagaattt gaagtggcat 108660 cgcgataacg gtattccaat ttcagaattg aaccttccag agccgaattg gtaacgctgg 108720 catagaacat atcaaccaga taattgccca agaaagaagc attatctcca ccgatttgtc 108780 cattgctgtc tgctgccgta ccgacgtcaa tcttgaatga agtatagctc gcatctgtca 108840 cagtaaacgt tttgttaagt tgttcaggag taaagccaca accgcctgtc aattcagaaa 108900 gagtaacatt gttcccagca accaaaccat gaccaggtgc aaacacagtc acaacagaag 108960 acccgcttac gcagttcaga gtgttcaatc ccaacggacg ttgttttggc ccgagcttcg 109020 gatcaaatgt tacaacgttc tgaccagccg caaagttgca acgatatatg cggaatttca 109080 tatcggccat ttggttcgga gaccaagttg aaccgtttga agaagtgaag aacacccctg 109140 tatacggttg tttggcgata tattcgttgg acagaaggtt tttcttgccc atttccgcga 109200 tatacgcgtt gtaatcctga gtattcgcca acaaaacgat agcaaactca gtcgatgctt 109260 gcagatacac cggataatca aaggtgaact tcgtaccgcc ggaagagtct gtagagatcg 109320 tcacttcaga cgggttcaaa gttttacgag taatgactgt atgagaaggt aagccattct 109380 ccatctcgcg aatttccaga gtgatcggaa catcacgtga cttggtagag aagaatactt 109440 ccacgccttc aatatactcg ccgccattct tagtcgctac cataaacgat tgggcaatcg 109500 gatcacgcca ttggtcgacc acaacttcag aagtgctggt ttcggtgcga gtactagcag 109560 tgtaacccag gacacgagtg ttgacaaagg tcttttgaat accttgtttc ttaccgaaag 109620 atttatgaac aatttctgca ttggtcagtg tatcatccgc agatttactg tcaacagggc 109680 tatccgttaa gcggaacacg ttgtcgcctg tgttgaactt gattgtatcg ttctgtggaa 109740 cgcggaatat acctttaaca gcaccattgg catcagtggt gattgggtca ccgaaattac 109800 caccattcgg tttgcaatac agattgacgt cacgaccaga gaagaacgca tacatacgag 109860 tgaaaggtcg cagcccagat gcgtcgaaag aaatatcgat ctcgcgcatg tatgggataa 109920 cttgcgtctc cacaatctgt tcaccagtca tggtcgtggt tgttttgtcc gtgtatgtat 109980 atgtggtgac atcacgggca gaaacagtcg tgcggtaacg atatccccac cacacaccac 110040 cagcaccatg cggttcccaa acacgatcag aaacagaaac agtacgccat gttccgtaca 110100 ctgaaccttc ttgtacagta ccacgggtgt tgatcgtttc attgataata cgcggtgcaa 110160 cataatagtt ttcgaaccag tagtctgtgg tcgggttaat cttcaagaaa ccttcccaat 110220 tgaatactgc atacgggtta acgttgatcg tcgtcgtcgc atattcttgg ttcaccgaga 110280 tttcaggcgt gtaattgcaa accaccatcc catccatcac tttgttccag ccaacaggag 110340 tcatgtcaac aacgttttgt tgtacaaacg ggcgcagacg tccgttttcg gtatcgatag 110400 aacccatcca atcttcagac aagtcatcaa tcaaccggaa gtccttgaac ggatcagccg 110460 caataccatt tttgaaacgg ggattacccg tgatggggtc gaacacttgc tgtgtcatcg 110520 ctgaagattc cagctgtgac agggaggtat agtattcaac attggaaata cgggtttcca 110580 gtttaccgat atcgcgcatc gtataacgac gattatcaat agttcgaatt tggatatcat 110640 caatattcgg tgtatacggc gggatcaaca attcatacaa acgcatggcg ttcgctggga 110700 ttgctggaga agccaggttg ttagaactaa tgcctcgagc cacaccaaac acaccgttgt 110760 ctgccagata aatcgcgtca atacgcggca gataatattc tgtgtccaga ataactgcag 110820 tgtttggacg aaccatatct gtgtcagaag ttccgttggt gattttcgga cggaaatcca 110880 aactatctgc caggccgtac accgcgcctg atgtagaaga tgtataattc gggatatctt 110940 tataatccat cgaagtatac gaatcagcag agaagaaatc accggaactg tgggcgaagt 111000 attgatacac cactgtatac gtccctgaga ttgctccagc gctggataac aagttagact 111060 tgtaataccc tgcatcacgc tgtccgccat ctaggacgaa gctggaggtc acgtctgcgc 111120 cagtatcgtt tttgaccgat accaatttcc aaccatcgtg attcgccaaa ggacggctag 111180 tctgcgaggt gaacgtcact gtttcagttg tttcagtgat ggtcttcgtt ttgattgtgg 111240 ccgtggtacg aatcatcagc gccagcaaat tgattgactg gttagcatta ccactaccca 111300 gagaaatctg cagcgccgaa ccgaccggag aaccagtcaa agacaaagaa ccagagatat 111360 cgaactgcgc ttccgaacca tctgatttcg ctgcagagta caacgaaaat tctggggaaa 111420 aactatatcc caatggagca gaaatagaac ccgcgccgct gttgtccaac gtcactttat 111480 acgttctgag aacagtgtag ttgatatcca cggagccagt tggtgctaaa gtcttgacac 111540 cgaataccgg aagagagaag atcagatcta tcatagaact ctggttaaac tgattggatt 111600 ccagttcagc agagaacatg gtgataccgc tttcttcgta agacactttg gtgatagtgg 111660 atgcatcgcc agtaacgacc aggtcgcgca tatacagacg aaattctgtt gaattacgtt 111720 cagctgatat acaaagtgct gtagcctggg taacgcctga agcattcagt aatttgtatc 111780 gaacggtgcg ggatatcact ggcacacctt tagaattctt ggtgaccaga taattgcctg 111840 tggccaccgc aacaggggtg ttgttcagga catcggtatc ccgcgcctta tcaacgatca 111900 ccaactcttc cccgacgttt tcgatacggc gaccgcgaac ataggaaata cctggtttca 111960 ttacagacac gaatttactt tcgtcgccgc catcagcagc attgaatacc ccgccattgt 112020 tattgacttt caggtgttca cgaatatcga tctgatgagt cgaaacgtta taatcaccat 112080 tggtttcata agtccgttgg gctaacgtgt cttccagaat attataggta gactgagtca 112140 ccatagactg gattttacca tcacgaactt tggccagttc aacaaagtct tcaaccacag 112200 catcataatc aaatcgagat aagaccagat ctattcgaag acgatgagcg cctggggctt 112260 tggagttaat cgttccctga gcatttgaat aaagggattc gtcttcagat tcagtcacga 112320 tggtttcagt gactttaaat ccgatgcggt gggaagtgat gttagaagtt ttatcaacga 112380 taagagttgc gtcatcaacg tctaggaaca tcccacgaat gaagtaaacg cctttcgtca 112440 tacgagcgac gatagaacca gtcaccgcag ctgcgatacc ataaccaata cgaatgaaat 112500 tatcattcac gtcgtaagtc tggaaataca gattatcgtt aacatggaat ccgtcagcat 112560 tacccgcttc agtcatctca aggatagcca gcatcgtatc aggagcagac agatcacgtt 112620 caagagacaa aacacgcgct ttggcgttat tgtctttccc caaaacgtag agttcagaaa 112680 taccttccag atcggtgaat tcagtaccac ccgccaaagt gaatttcaaa gagactgcgg 112740 cgttggtgat cgtcagaccg ccagggataa ccatagaacc atctttgaac aaatggttgc 112800 ctaatttttc aatttgatcc tgaagaatag tctgcatctg gttcagttcg cgagtctgaa 112860 ccttgatagg catcggacga aaaagaatcc gtgaaaaacg tttcccagga ttccagtcat 112920 cccaatacgg gcgacggttt aaatttgtag attgcatttt gatgctccat cgagtgccat 112980 tttatagaga tatttagtat acaaccaaca aacagataga aataaaaaac cccgccaaag 113040 cggggttttt attatgatac ctttgataaa gtaacccacc ttcctaattg ctcaatgaac 113100 tgaattgtaa ttttcatacc atcagtcatt ggagtcaaac ctgcaccatc gattgtttct 113160 gtagataata aattgaaatc agtggcacca ttacgaatga aggtaacagt ctgcccatca 113220 tacccagcgt gtaaggtaat attaccagta ccctcaacaa tatatgtgtc aaattcatat 113280 tgtttcaaag ttaacggcgc agaaattggt ttacatatcc gcttaggcag gaaccctatg 113340 gcattcttgt ctattggttg gaatggggtg ggtccagtac caacactagc aggagcacgt 113400 tcaatgttag ccccattaca tagatgaata ttaaagatat caatttttga catcttccat 113460 gtacgaatat ggagctgaac actataagta tcactgtcaa caaattgagt aggaacactg 113520 tggaaatgct caacaatctt actaccacca gttaaacgga acgctttact gtaaaggata 113580 tcaccagtaa tagcctgaat cttcagcaaa aattctgcat ctccaggata accgacttcc 113640 tcaaccatac gcaatgcaat cccgaaagac acttcacgca ggaaggctgc agtaacgttt 113700 tgactaatca cgtaataatc agattcggtg gcttctcgat tagcaacaat acgagaccca 113760 taacgatact gtgtagaagc accgccattc agcaaaccgg aagtaataga caggtcacta 113820 gtctgcgcag ctccaccaac agccaagttc cattgtggtg ccagtaagtc attggaactt 113880 acgatatact gattcacctt cccctgagca ataatctcac gactaccttt accaattact 113940 tcagcctgat tcgacttaga cagagcagat tgcaagttct tataggtaat ggtggagtta 114000 cctacagtaa caggaacacc gttatcaact acatcatcca acatctcaat ctgagactgc 114060 ataccaccaa cttcatatcc aaactgtgag cgagtattat tacccccgtt cttaatctgg 114120 taacgggcat aagggccatt caccaggcca ggtgagttac aggactcgat ataaccgaag 114180 aatacgttag tagaaccatc atctacaaat ggacgtgagt ttactgtacg acgacaatac 114240 tcaatattgg catacacttc attagtgtta gaactggtat caaaagtaat accaacttcg 114300 caggtagacg ggtcaatctc ggcattacta aagccaccac caatcttacc gaagatacgg 114360 ttagcgttag ccactacgca tcttacgcca cgcaatgaat cataacattc gcccacatag 114420 atggctctgg tgaaacaagt atccagtttc acattggttg caaatccatg tactacgtga 114480 ataacgttag ggattcttcc ttgccccatt aactgaaatc caattgtttc atcgataact 114540 acagaatcca gtgtgccagc ctcttctgcg atctcaaata tcttgccagc tagctcacca 114600 atttcaaaca cacatccagg agacctgttg acaaatgcaa ctcctgttgc tgctgtgtat 114660 accaccttgc gcaatttgat ggtcatcaca ttgaagtcat aacgcacagg aggtgtatgc 114720 acttccggaa cttcataggt attggctaag tgatactcac catcaccaat tatgttggcg 114780 ttggcaggaa ttgcaaaatc ccacatgcgc tgaaacattt ggtcatcatt ggtatccgta 114840 tccagtcgga acatttcagg agtgacatat ttaatggcgt cgttgacagt gccgttaggc 114900 aaagaaactc caatttaccg ccaagcacct aagccaacgc caccagttga tgcaggagtt 114960 gaaccaacag gaacaacttt aggtaatgca ccattccaac gatatagact caccccatcg 115020 ctcacgactt cgttcttgac acgaatcgta aatccagaag tgaaattttc tatcagaatg 115080 acgtattcct cacgcaatac ggccagcgca cccaaatcta cagtgcctcc agagtgtgtg 115140 aggatgccgt cgaccaaact ggtgactgtt acagcaccaa tgttagaagg gagagcgtag 115200 gcacgttgag acaacttatc gtagatcact ttataaccag acaatgactg tcccgctttg 115260 gcataaacga cttccgactt tttacaccca aatttacggg caatactatc tttgttcgat 115320 tcttttgaag tagaaccttt tggttgagca aattgcggat tcatgatgaa tctcctgttt 115380 ttctaataaa ccctcccgaa ggagggggaa attaaaatgc aacactgatt ggagctgtgt 115440 atgtgccagg tgggacggca ccagcccaat atgcgatagt tgccccactc acagcattca 115500 atatttcgga tccaagcaag gcttgcttat tagtgaccgg atcaactgca aacaccgtag 115560 ttgttcccac gtcagttttg cgccacacat taccttgaga tttaattgtt aaacctaaga 115620 cgccagcaga ctgtcctgaa ccacccgaag acacgaagtt tgtggtatta ttcaaataaa 115680 cgagacattc ttcaaagttc aaagtacacc aaccaacaag actgaataca gtaccattga 115740 atgctgtatc tcccgtttca aaatatgtcc ctttgaaaga aagttgagta ctggaacgta 115800 agtatgttga agtgttatac ccttcgatcg aaccgccgat gaacaccaca tttcgaaccg 115860 ccaatccata atcgccaatc tggtttacat aagcacgcat attgatatgc ttggtattga 115920 atgttatatc ctgtccggat ggaacacgac taatacaata acaatacaga atcgtcatat 115980 gatccgtagt ggaataataa tcacctttgc tggcatccca tggattagaa tccaacgcgt 116040 acttcataag cgccacagta acatttcgca cgttaatggc ctttccatga cggaatgctt 116100 gggtgtcaca atacgaagcc gccgaaggta atgatgtcgc caaatccatc ccagtagttg 116160 taaaccctct tccgtacacc aaacaatctg ttggtgatgc accttcacca caacggaatg 116220 cttctccagt cgcagcatca aagaagacag cattttgtac agaacgcgct aaagaaggat 116280 cagaaataac gtgcaccccc tggaaattgc tgggctggaa tagttcagaa taaacagaag 116340 tcatttgggc gtatgaacca aaagtctgtt tattgggaat atcaatataa ctcgtaatgc 116400 gatggcgacc tgtccatctc cagcaaccac cccgatatgc cacgttggcc acttgttgga 116460 attctttggt actgtcatgc gcgtccccga cgttccaagg aagcgcacca aagtcttcag 116520 cgcggtaatg acccatcacg tcttgacgac gccaaactcc agtacctgtc ccgcttgcgg 116580 taaaccaaga agtcttccct gcgctgtccc aagtcgggaa cgttttacca ggatcgatga 116640 tcgtgccgcc gttgtgagca gccttgttcc cagaaggatc ccaacggaag aaaccaccac 116700 cataattggt tgatgggtgg aaagaagtca caaacacgaa ggtcgtttca gttggagaca 116760 cattcaaaag ttctgccata ctaccaacga cacggtgttt attgatatta ttcagaatat 116820 cttgtactgt gtctccactg gaaactttaa tattttctgc gccgcttggt tgtaaataga 116880 ataatttaac cgcctgagaa gaatctggta atggtaagag atcaacctgc acatcacctg 116940 ggttgtaatt caatttcccg tctgagatcg tagaaatgac agaaccatca ggaatggttg 117000 gtaaaccata actggtttgc gtcgctatgt cataaacaac tttcttccca tccaacaaag 117060 atatggtgtc cgtactaacg atgacttcag agtctttcac attagcagaa cgggcgattt 117120 cttgaatact tcggtcaaac gccggactga tattcggttg tttaacagac atttcagcga 117180 ctacccaaac gcctgcagtc agtgcagttt gcaaagacac tttccctgtc gtgctgttat 117240 aggaatattc aatttcgggt gttttgtact cgccaccaat ataaagagat tggactccat 117300 aagatgtgaa atcaggagta aactcggttt cccctcctac ggcctgaaat ttgtatatgc 117360 ggataccttt ggctgtatct tctggtgaaa gaattttatc gaataagcaa tacacaacat 117420 cgcctttgga caatgcgcgt ccgagattca acgtatttcc ttcgatttca aagttgtcta 117480 acggaacttg cataccaccg ttgattgtga taacaccagt gacgggatag aacggcaagg 117540 aaagaaaagt ttctccaccg acatttgatt tatacgtgaa aggaatctgg tggggagctg 117600 tgattacgcc gccgaataat tcttctacat ttctggtcat ttgaaaatac cccataaagg 117660 atttgccaat atggggtatt tagtctgaac taataaaatt tatgaacaaa ggtataataa 117720 gaaccccgcc aaagcggggt ttttgctcaa gataaattaa agtgtgtatg ttacataact 117780 tccatctggt tttttagcaa gcaacctcaa tgctccgtca cttccgaaga agaatcctat 117840 agatgaatta tgttccagag cgctctctgg taattgtaaa ggggcagcag gtatactcat 117900 atgcttaaag cctaagcggt taagctgaaa ctcacctaca cgtacaccct cctgaattgc 117960 cgaaagcttg acaatacttg cctcaccccc tggtgtagca acctggcaat ctgccgtcat 118020 aagcaaagat gggtttgtag taccacccat agcaggttgc attgcaagtg tcatttggtt 118080 ggcactatgc tgaacattga tattacctcc ctgaatatcg cttatatagg tacatagtaa 118140 tttcttagta ccggaaccag cacaggaaac attacttact tctgaagacg gagcgtatat 118200 agcgtaacct tgtgtagtat atgcatggat gttaatacca cgaagtctac tacctccctc 118260 acaggtaagc tgatttaagt tagttaaatc cttattcgca cctactacag taatgttagt 118320 aatatcattg ttagtacccc tatcgaagac gccttcctta tgggcctcat aagtaacaac 118380 attatcaata atatttttct gaccatccca ccaagcacca atccccatac aatcacgagt 118440 aataatatta cggatgatat gttgagtagg taggtggaac catggatact ctgcgagtga 118500 gtagtcatcc acacgttcag ttggcgaccc tgtgtcagca ttaacatcaa taccatcata 118560 gtaacactgg attgtagtta tattgtcgaa cactaaacgg tagttcctgg ctgaacgacc 118620 tccaatttcg ttctgatagg ttttaatacc tgattctcca acacggtatg agattaaatc 118680 tcttactcca ccatcatggt ctgtaccacc atcattgcga atgaacagta cagcggaacc 118740 agagccatat ttaatctcac ccccaacaac ccagttgcca gtaccccatg cagttgtatg 118800 atggttctca aatgtaatac ccgattccaa agcaataaaa ttgcgtggat tcttaacaag 118860 aatcctatta cataaagtaa atagataacc accaaatgta gcttctgggt tctctacgat 118920 gatattatcg ccgctcatta ttcgcaaagt agcaccagca acctgatttt ttacattatc 118980 aggaaggtcg tcccaaatat ctaaatcgtt aatatttggc ttatatccaa catccaaacg 119040 ctgctgaaca gatgccagaa cttgtgttgg gtctgtaacc caattaccgt ttgcatcgaa 119100 tcggtaaaca gtatacggcg tagttttagt atgcatgtgc ggtttcttaa ttactgaacc 119160 cgcacccaaa ccattccaaa ccaacatacc atcgccaatg aattttcctt tgcattcaat 119220 gattaaaact ttaccgctaa aatctacact ctcatctgca gtaaaagtgt agtcaacatc 119280 aataagcaat ccatctacgg ctgctgtcgc tgcatcctgt aatgtagaat aatcagataa 119340 ctttactgaa tatttgaatt ttttgttggc ttcctgtcta aatgctgcgt caccaacact 119400 caaccatgca cctaaaccaa cgccaccaga tgtttcaggt gttgagccag catagacagt 119460 tctaggaagt gaaccatccc atcgatattt tttatcatcg tgaacaagaa gttcattttt 119520 cacattaatg gtatggccga aattaaaaga accaggtaaa gtcacatatt cttcgcggct 119580 tactgctaat tccccaaggt caacagagcc agcggaatga gtgaggatgg cttgttcgtt 119640 cagacttatc gcagtcgttc ctgaaacaat acccgaagga agagaataag cccgttgggt 119700 agactcatca taaattactt taaatccgct gagatcaata ccgacagtga aataaatgac 119760 ttcgtcttct ttgacaccga aatttcgagc gatagattgt ttgttaactt ctatggaagt 119820 ggagccgcgt ggttgattga attgagaaat catgataata ccccataaag gatgaccaat 119880 atggggtatt tagtctgaat taacaaaatt ttataaacat ggatataata agaaccccgc 119940 cgaagcgggg tttttactat gatgtaaatt tcattgcatc ccatgttgta ccattatgtc 120000 gatacccgaa aatatttgat gccccagcaa taacatcata tctgtcacca gacgcattac 120060 caaaaggcct gtcaggaaca gaagttgtgt cagttgctaa aatgccttta aaccaccatc 120120 cattctgggt gtttggtttg tatttgtaaa attgtttaac atatggttga gttggcgagt 120180 caacattaat ttgcccatga ataccagcgt atccgtataa aggttcactg gtattcacat 120240 cactgtatac atcaatgttg aagtagtaat cctgtacgga tagtggagct atcccaagcg 120300 ctggatgcat ccatctatct gttttaatat cagcagtgaa ttgcacaaca ccaacagtca 120360 ctcctgctgc ttgttgtaat aaacccagga caccaccaaa ctgacaattt gtcatattcc 120420 atttaatatg catttcagca aggtgaacaa gataatcgtt ggcaaattta ttggtaaacc 120480 ttatggctgt gttgtctgat aattgaggtg aaccgttggt cccgcaagag acaaaagagt 120540 cattgctgtt gaaagtagca cctgtttttt gtttacccaa gcgaacacac ccccaaaaac 120600 ctgagaaagt gttattttca ctaacaactt ctttgaaata gtccaggtca taagcaacgt 120660 ttgcagcttt ttgttcagtt gtccaatctg tggctctgtt tttttgcaat atgttattat 120720 ttgcagagta aataattgca ttaatagtgg ttgggtcaga tgacaaaaca gacggctgct 120780 gtgttgtgaa tgccgcagta ttaggatacc cgataacttg cttttctgat cgtagcgtta 120840 cagtattacc aataaatctg gcaacagttg taacgttagg tacggtatcc agaaccaaag 120900 cactacctgc gtcctcacag acgttatttg tgaaggtgac tatagatgtc gatgtagcac 120960 cgtcgttagc cttcaggaat gggtagcgag cttttttggt gatgcatcca tcaacgatcc 121020 cattaccatg acactcaaat accgtacaca tgtctgacat ggttggctgg atacatttaa 121080 cgttatttat aacgtagcca tcggaatgaa ttcttattga tgagtggtct gttaggttac 121140 tgtttccagt cacagcgtca gcaacgcgat agaagttgca attctctaca cgcgtattgt 121200 agctgttgaa cgctgcctga gcttcctgga ataccattac gtttgcacca ggagcattct 121260 tgacgttaac accagaaaca accacaccgt tactaccttc gtaacatgct actgctggac 121320 agtgagcttg tgctccagac cagttcaatg gcgggacaag attattgtca ccattttcat 121380 caattagcat atcgtggaca tatgcgttct gaatttcacg aataccatca ccgaaaacta 121440 caaagccttt agtgcccccg ttttccttat tgcgctcaac aacaccatcg gcaacataca 121500 gtaacgttgc gtcgccatcg ccgatgaaag taacgttgtt gcgaagaaaa atcataactt 121560 cctgattacg ataaatagtc agaccatgcg ccgtgccttc cacaagagtc gttttatcca 121620 acagataagt gccagcagga accatgacaa cttgctggga tccgaatagt tccgcacgtt 121680 tctccgcatg ataacctgcg aggtttatag catcgaccgc gtctgcaccg atcttatctg 121740 cgatagaata attattatca gccccccagt taagtactga catccagtca taatctgtta 121800 aatatccaac acagtaaaaa tcgggatagt ctggaacagt tcccggcgct actgtataac 121860 caccactttg tatagcacca tatttaaccc agaaaagacc acttgaatca acaagagctt 121920 gctcgttggt ggttaaaact gaaccttgca agaaagaccc aaacttctcg aatttactat 121980 tgatataatt attagctacc cactggcggg cagtggcatc accaacactc aaccacgctc 122040 ccgaaccaac gcctccagtt gttgctggag ttgagccagc agctacagtt ttaggaagtg 122100 taccatccca acgatacttt ccatcagtat gggtgagtaa ttcattttta gtattgatga 122160 cagcaccaga atcaaatgtc ccagccaagg taacatattc ttcacgagat acagctaatg 122220 cgcccagatc aacactacca gcagaatgta caagcacagc cgaagaacta aggctgactg 122280 ccgtggttcc agtcggtaac tctggaataa aatatgatct ctgtgttact ttatcataga 122340 taactttata cccgcttaac acagcaccaa cactaaaata aacgacctct gtatctttaa 122400 cattggttac acgagccact tcccgcaaag tataatcaat ttgattatag atgtttggcg 122460 ttccattgat aattacaaca acttcatcct ctgcatccag ttcttgcgca agagtgattt 122520 tactggttaa tggatcgaat gtgaacccca gatttttata ctggcgactt ccgtttatat 122580 caatagccgg aacatcatca acaacgacgt ctaacgtgat ttcggtttca ccaccaatcg 122640 ctgaaccccc attatagacc caagtaatcg tagaagaact agaaccaccg ccattaccca 122700 attgaatagg agtatattca atcacctgaa gttctgtgct ggctggcaaa gaaggactga 122760 aagtgattac attcccatct agtgaatatt tggattccgc aagacgtttt ccgtcagcat 122820 acacgtccac gattgttggt ggagtattga gagtgacagc acttgtttca gacgccaaaa 122880 tttgtgtaaa gatttcacga ctgtagacac ggccttggcc aagaccgacg ccggatgtga 122940 taacccaacc ttgttcaggt ccagaccaag tgaacgttgc tgatacgtta tcagttgtta 123000 tagccatgtc ttcagtggag ccatacaaat tatttccaga aggagacacg gtcaatgggt 123060 aagtggcaaa tttcccataa gcatcacaaa tagtaacgga atccccaata cgcgtagggg 123120 aagggagaac cactgtagat gtccctgtgg tattattaat gatatagcca cgaccttcta 123180 acaaattgct agagggagcg tgagggagcg tttcccagcg tattccacca ccccccaaag 123240 acaaccaacc accgttttcg taataacctt caaattcatc actatcagga ttgtaacgca 123300 cagaagatgg aagacctgta acttcagtat cttcaggaaa tgtcattacg gcaccagggg 123360 aatgctcaat agtgccggag ttgttgaagc cttttatgtt cgaagactca gaagtttcta 123420 aacccaaagg gaaaagaggc tgtgttggtt tgttggccat ttgtaatacc cctaaatgta 123480 ttcatgtcat ctaggggtat ttagttttag aaagaagctg taatagaata atcgacagaa 123540 caagcggttg tcgtattcgc attaacaacg gaaattctca atttaccacc caccacagcc 123600 cctgtgaacg tcactgtacc gctcgtactt ttctgaacca acaactctga tttgatcgtt 123660 ccgtcacgag ttatggttac tcgatatgtg tcaacaacgt tacctgcccc ccattgcgca 123720 gttaccagta tttgacaaag gttcaccaaa tcaaaatcgg gaagagccgt cgttccagaa 123780 gccgaaaccg tgtatgacga caaattcgtt ttggtacgat aaacggcgtt ccccaaactg 123840 ttgtcgatag aggtcatctt ggcattatac gttgatacac taactttatc actggaaaga 123900 gaactgatgc tgttatccag agatgtcatc ttcgtattat atgtgctgac ctcgacttta 123960 ttacccagag acgtgttgat attggagata ctcaaatcca acgacgccat cttagtgttg 124020 taagtcgagg tgttgacttt cccgttcaac gacgtgttga tgttattaat ctgggactct 124080 agactcagca tatctgcgtc atacgctgtc gttgtcacat atccattaaa tcggttgtct 124140 gcaaacaacg catcaaaaaa tgcagtcatt gtccaataac gcgctccaga atctgtctgt 124200 acaggaactg aagtcggcaa cgttggtccg gtatacgcag acaatctggt gaaatccaaa 124260 ttgaatttgt aatatccgga tgtcaacaac tccccagcca aaccagaacc aggcggggta 124320 gtgtcttcac tgacgccatg ctttctcaac atgctcaggt taacaccatc tgtcgagttc 124380 gttggttcat ctgtgattga aacggatttt ccggcgggaa cttgtatgcc cccattggtc 124440 accaacaacg cattgaaagt ctttttgcca ttgattgttt gttcaccact atctgtacga 124500 ataactttgt tggccaaagt atcattgatt gtgtcaacag atcttttcaa ctcatatgtc 124560 aggcgagcag atggtggaaa taatgggtcg ttaacttcaa aatcgttaat aacgtcattt 124620 ttacttactt tgtcgtcaac agaacccaat atctgatcta tctgctgacc tgtatattga 124680 ctcaggaaat cggccatttt tagctccttg tgctttctag gaatacagta aatccagcag 124740 gatggaaatg ctgacggaag acgcgctcaa acacaccttc aaaatcagat acgtcgcctg 124800 ggactcctat aacataagtg tattcatcat aatagtaatc atcacgcatc cctgtcgtgc 124860 cgtcacattc aaaatttccg tccagaccgc ctatgtcttc tttcgtaaaa tagacgctga 124920 ctggacaacc gaaatatatc caaaagaaca attcaattgc tttcttggtt ccgcggattt 124980 tatagatatg ttttaacagt ttcaaccaac gcggatgatc cagagttctt cgtttagttc 125040 cttcgatata aacagagaac gtatcgcccg tggccgtcaa taaagaatcc gaaccaactg 125100 ggataaaatg accaaattcc tgaaatgatt tatcaacagt tcgttggaaa ccaaaatcat 125160 tataccagtc atctatctgt ttgttcttat cttctattga cagtagcggc cttccgtcag 125220 catctaaaag ttcttcggcg tccagagcca tcatgttctc aaaggtacga accaagaatt 125280 tatcagacaa ataatccttg gcctctgagc ctggggtctt gtcagccttt aaatcaatca 125340 gctgtttaac tggagaatct tcactctcgg gattcatcca actagacgta tctgccagat 125400 atgccaagat ctcttcttga gtgaacccct gctgtctata cagccaattg aagaacgtgt 125460 ccataaattc tatgaacaga gggaaatcat tctggtagaa caacggagtt tcatacttaa 125520 ccccgttgtg tccattatta agatctttgg acatagcgca cctctggctt aacaaccaca 125580 tcaccaatct tgaatacttg gttttgtgta gcctgtatgt tctggttcag tccatccggt 125640 aacacgacta tggtcacccc ttcagggtta tagttagaga ccgtgatctg ctgaaggtct 125700 acaaccccat ttgcataatc tacaacccct gttttttgaa ctaaaaactc ttttgtcgtg 125760 tcattgttat tcactttata catgttcaaa tcgccattat tgtcgcgcat gtagtaagtg 125820 aaatccacct cggcaggaag cggtttgaac cccgttattt tcacagaacc aggtttgata 125880 cttcttccat aactgaatgt aaaactgtct aagactccat aatcgggttt gaaatggcgt 125940 ttataaccaa ccgaagtaat attcgagtta atagaacgct ccatttttgt aattgcttcc 126000 tgcaatattt ctttgtcaaa caattggtca aatccgccga gattattttc accccattta 126060 acgatactgt ttccaacaac aactttcatc tgttcttcaa cgtagactgt agaagtagga 126120 tcccaaaata tagtcgttga gacttggata tatgtgatct cggaatctac cactttgggg 126180 gtgatagatc ccacattata cttgtccaga gcagcaacga tatcggcctt ctcagcgtcc 126240 gaaagtgtct caccaacaga aggtataaca gcgatgtaaa catagccaga atcaggagga 126300 gacagcgtgt caccaccata tgatttagct cgggagacgt tggagaataa cctttcagtc 126360 aatacaccat aatctgtttc tgtaaccgca gcaccatcag cctgataagc taaaggagcc 126420 aaccgtttag tgtcctcaat agattccgga tcgtctccac ctgcgctacg ttcggaaacc 126480 aattctacat cgacctggtt aaacccgcct atggatgacg ctgatgacag gcttgtgata 126540 tcattcccat cagcaccaga agtttctaag tattgaagga atatgacgtt cccatcttct 126600 actcgacgcg aaagataacc atctccgaat tcaaacacat acagaccatc aatacccaat 126660 tctacgaaat acaggtaggc atattggctc agatcaaatg gactgttgta acgttgatat 126720 gtcgtcgaaa cgtcggaaga ctctgattct tgtacttgca cgaccatatg attgatatcg 126780 acattcccag aaggaatcgt atatgttgaa atcgcgcttc cttcaacatc atatgtcttg 126840 tacaaccaat tcccctgtat caactttaca ttgttgaaca tgtaataacc gtctgcagtc 126900 aacgttgccg acactggttt ctcaacagta aagttgtagg aactgccgtc ttttgcccca 126960 acgaacatta cgcgccgatc catgatgatc tcattggggg ctgtgctggc gtcataaggc 127020 gtaactttga tgttgacata catgtatgct gcccgatagt tgtcaggcgt gtaggaaaga 127080 aatgcagcag ataaaccgac gtttgaacgt tgatttgctg tcttcaaatg gccttcacca 127140 ttaagcatgt tttgcataaa ggctatggcg ttcgcgtcag atgccaacaa acgaataatc 127200 gcactaagac cagaaccttc aaagtcataa tctttaaagg tgggatcagc tttcattcgc 127260 tgtttgataa tgtactcaaa ggctctgacg tcgagtgaag gaactgtttg cgtggccatg 127320 ataatctcca tcacctgagt ttgaatatgg tgttgaagat atttagccaa cgggaatcaa 127380 aacgctcgcg cgcgtttaat ttattcgaat atactcgcga gggggctgac gccctcgctc 127440 gtaacaccgc cttgacaggc agtcccattc cacagccatg gaggctgctt ctcgttgttc 127500 gttaacactc acaactcgaa gggcaccgcg ttaagataca gtttcttgat gttgtagaaa 127560 agtagttttt acctattaat aaaccgcgct cctatttcgt tggactttaa ttcaataaca 127620 ccttcactaa tatagtagtc cggtcaatca accgtatatt aaggaacctc tcatgcatat 127680 caacaccgct gtattaaaac acatcatccc tttattagag aaatacgaag ggaagaaggc 127740 gaaggatatt tcatttgaag acatatctgc tgaagtgaaa cgcctgacac gtaaagaagt 127800 caatttccgt cgagtccttc catctgcgat cgatttggca aagtctgatc tcaacacagc 127860 ttccactttc tcctttaaca ttgacgccat gtcaacattg gtggctgaat taacccaatc 127920 atcacaagct cgccgtgacc gcttccgcca tttgtgtgtt gaaaatcatt cccacactga 127980 tcgcatcggt atcagactcg aagcaatccg ctccgaggtg tgcttcacgg tgaactatat 128040 cctggagccg gaaacccagc acatttattt cgtggccatc atcggcttct atggcacatc 128100 cattaatgga tgggctgagc gcgttgaatt aaaagagacg ctgaacaaac acagcatccc 128160 gtctacccat tatatgtcgc gtgaagccgc ccatgaatat gtgtatctgc tagagcgcga 128220 tgtgaagtta aaagtgttaa aataacgctt tattcaataa ataattgtag taaagttatt 128280 ttcatggaag ggagggaaca ctatgtttta catgatgtta ctcctcatcc tcctgatcgg 128340 gattacctgc tctctcctgg gtcgacccga tcagtccggt acacagtcgc ccatttcggc 128400 gcatccggtt ttgaatgaag gttcgtccgc actgctgtgg gcagtgtaat tcaaaggggg 128460 ggggaggatt tttcaaattg gctggcttgc agtaaagtat caaacatgag ggaaacagca 128520 cagtgtgagt aggcttgaaa ccgaaaacag tgaaccccta gtctctgggg cttgtgtgaa 128580 tagaggcgta atagccacct cgctggtgtc agtggacgca cttgaccgtc ggagaacgaa 128640 actccctgtt gtagcgtgat tagctcagaa tcagagagca ccctgttggc aagtcgacac 128700 caacatataa ggggaggtcg ggggcgctaa tctccatcac gccgacaaca ttatgagtct 128760 tcatagaggg ttcataatgt tgcgtcaaag ggcaacacga ggattcctgt tggttggatt 128820 aacttgattc atagttcctg ctgattcttc ccggattcag aagagcaccg acaggacgag 128880 gccggatgcg taagttccgg caaatcgatg gtgaggtggt gcattggtga cacggggtag 128940 cgctcagaag tgtggttcga ttccgcaccc tcgccaacaa aataaaaggt tttatcaata 129000 acgggttaca aagtatagtt aactcactga acggcaagct gtttgagtcc tggccactca 129060 taacgatgtg agaccaagac aggtaggttt aggactcaaa caggttttcg ttctccagga 129120 ttataactgg gaaaactttg aagcgttgtc gtttgcattc caacatatca ggagtgcaaa 129180 tatgaaagag ttcagttgtg agcaggttcg tcactggttt gattatgatc cggatactgg 129240 cgaattgact tggaagaatc ctcgttcacg aagatgtcaa cctggtcaga aagtgggcag 129300 tgtctccaat gatggttatc ttgtcgttgg gttggcgggt aaacccagac ttgttcataa 129360 agttatttgg tattatatta ctggtcactg gccggagtat ccggaagaag taatagatca 129420 catcgaccga aacaggttga ataacaagtg gtcaaacttg agaattggaa ccgtcactga 129480 aaatgctcag aacaggtcta ccaataagaa ttcgagcact ggttgtaagg gtgtgtcctt 129540 cgataataag acaggaacat actacgtgca gaagcagaga aataatatac ggtttgttaa 129600 gcggtatatt agaactctgg aggaagcatg ccaaatctac acagtgttgt aaccgtggtt 129660 ttcgttttcg ttgtgcgtga ctttgcgggt ttttagaaac tgaccacaaa aaataatcgc 129720 taatgataac acgttcctgg cagtagctta acagccatac accagtgagg tcttccgatt 129780 cctcatcatc aaattcggcg cactaaaata gacgggaggg tgtgattaat aatctcccgt 129840 cgacgatgag cggagcaggt gcttaaacag gtttcaggcg tgagccagcc cctgatttgg 129900 ggagcaccct gggaggttcg attcctccct ccaatcccaa agccgttata tctgactgtc 129960 caaaggggat aagctcctga gtaagcagag gtgggttgcc taagtcagat gggatgtaag 130020 gtcagcgctg gccaagcatt tgggttcgac tccctaaaac ggctccacat cttagaggac 130080 attgacaggt ggaagcattt ggcgccaaat gctcgtggcg ggttcgagtc ccgtgcagtg 130140 tcctctaaga tgtgagcgaa gtcttaccaa ttaccctgat ctctggcaag tgaagggcaa 130200 cgcaaatcga agttctctgg gtatatcttt taaccctcaa ggtctgtaca cagaagtggc 130260 cgtcccatga gtaagttagg cgatatacaa catgttgggt cgaacctgtt aagcccagag 130320 aacttcgatt tgcgtacttg agagagcgtt gtatgaaata gggcaatgcc ttgcagacct 130380 cgacgcctac acattctaga cactggtggg cgctggcgaa gatctcaata taagctggtc 130440 atcaagggta gctccctgac tagacgaaca atgagaggcc gaactaaggg gaaacccgag 130500 acaggcgcag tattttcaag ttcgcaaaac agtgatcatc ctgacaagtg tgatcactct 130560 tcgatagaga cattacatcg tggctatcaa ccacatcctc gctctagtga tgagtggtgt 130620 catgtttctg tcggccagcc tcgtttggtc cgagcgatag aggacaagtg ctgaagcgag 130680 acgaagacgc tgaagtgcga gttgtgacat ttggttgcaa ctttgatggc tctggatttt 130740 ataaaccatg tctatgggtg acgcgggatc tttagtacca gagccatcaa agttgtgtcc 130800 aacccgatct tgcaagcccg tatccctgta tggtcaagac ttgcaagtgg aaagccctgg 130860 aaaaataaac gcctgtggtg aggctacggt gcaagccaaa gacccacaga agcgcgttgc 130920 cgtgaggcgc acaaacaggc atgcatgaac tgatcatgca caaacgggat aaagggttga 130980 gagaccttgg ttggacacaa catacaatta atccataacg ggagaagcaa tatgacttgg 131040 cgacagcgcg gatacaaaac cgtagaattg atttaaaatt gccggcgccc tggttgagtg 131100 agagatcact gccgaaacca ggaggaatgt gggagggtaa ataccctccc acagaccaag 131160 aacatatatg tttgtgtatt tttgtgcata aacatatatg gtcctgtagc tcagtggtta 131220 gagcagtcga ctcataatcg attggtcatt ggttcaaacc caatcaggat caccatatta 131280 aggggcgata gtttaaggga tagctgtccg gacggcgagt ccccagagag aacagctgga 131340 ggccaatcca gcaggtgagg tgaaaagcct cagaccccgc caatatttgt tggactgcca 131400 acaagctctg gtctacggca ggcgagatgg ggtcgcggga ttaaaatacc gcctcgggag 131460 cacctaaata aaccagttgt tcaataaaca attggtgagt atgatgaaaa cgttcggtga 131520 ttttcttact gagtgggatg gtctcgctac cgacaacaaa gagattgttg agtttgttga 131580 aaagcgaggc gataagtggg ttgtccttga ccacaccaag actaaagttc ttgggacaca 131640 tgacaccaaa gctgacgcgg acgcccaatt aagggcgatc gaagcgaata aacatagttg 131700 aagggttcta tattatgaag aatatttggg tggtgatttc caacagaatt cgcgctagtt 131760 gggaaggtcg gatggtgagc atcaagaacg ggtctcatcc aaaaacttac gatcgttatg 131820 atcctgccct gggtcttcat gcagaataaa gaatgtttat acgaaagtaa gaatagagac 131880 gatgtagttc agtcggtaga acggtggact gttaatccat atgtcgcagg ttcaagtcct 131940 gccatcgtcg ccaaattgaa gtagagtatc tcgaagcgcc ttcggaagtg cgaatcgcgc 132000 gatagctgcc aatgtaaggc tgcaggatac agatacccag gggagtgaga cctacttcat 132060 acgatttcag agtgtagagg ctacagtagt gcgcacctca cggaaagcta caccggacac 132120 tctgatacaa aatctaccac cgcgtggatt agctgaggaa ggatggccga tgtcctcaag 132180 cgtggcccag cacgtggtgg tagaccaaac acagtaagcg ttgcagccag ctgtgtataa 132240 aatggggtga ctccacatcg gaaacgatgc cccaacttcc agaaatggtc gggcgtgaag 132300 cctgtaaagt tccaggagat cagaccagaa ggcactggtc gccttgttaa ccaatcgacg 132360 cttcggcgtg gggagttgga caggcagatg aaatgctcaa tcgggtgtga agcccgtcca 132420 tattacgctc ggtcaagcag tctgtttgta gacggtcggt gcgggttttg caagactcgt 132480 ttaggctaac aaatggatga ggcgcgactc tctgggttga tcaccagagt gctggggttc 132540 aaatcctcta acgagcacca aacaacgtga gtgtggcaga gcggtcgaat gcaggagact 132600 gtaaatctcc ccgtaacagc gcggtggttc aaatccatcc actcacacca aatttgcgat 132660 catcgcggaa atcccagacg cgagtggatg ccagggcgga agactggcac atgggcaccg 132720 acggcaaagg tgctctaact cctggaattg ggtggcctga atggtaggga aagcgagcca 132780 agcgttgtgg gttcaactcc cactcaccca gccccagatg gaatgggtcc atcatcgcaa 132840 atcaaattat gagtgtgact tcctgaagat gaagaaggtg tgcatgccga cttcataaca 132900 atctggggtt aaggaagtta agaaagtcgc aggatatgca agtgaaatgc aaatagcttt 132960 cagcgtcctg acgatttcgg gttcgattcc cgacgcactc tcccaaacgc ctaatactag 133020 aaattgctgt gagtagtctt tccatcccca cgatggttta accatagccc gatcaggaag 133080 atcgggcttc tttttgtcta taataaatag atctgacttg taaaggaggt ctattatggc 133140 aactgctaag atcataccaa acgcaagtac atggacacaa gtctcagacg gaacatcttt 133200 gaaaactctt caagtgactc acggttctgt gtatttgtgc gatagcccta gtattccaac 133260 gggtaacaac gcgcacatca tatatcaagg aaatatggtc gttttaaccc cgccgacggt 133320 gggttgggtt aaggcaatta attctgatgc gacagttatc gtttcttaag ggggagatat 133380 ggctattttg acatctccct atttggggaa tatgcttcag acccaccgca ttaaaacaga 133440 agtcagattt tctggattgt cacaactgct aacttctggg gcaactggaa tagatttatt 133500 aaccgtgttg gatgggaaga ctccgaaccc ttcttctcct actggtttag ccccgttttt 133560 taaattatca gatcacaaat ttcatgcgtt tccctatgat tctattcttc cggtgaaggt 133620 taatattgtc ggatcatggt ctgggtctac ttctaataga actatgatat tagattttgt 133680 gggttctgtg gggaaccagt tatcaagaag tcgtgatgct agcgtaccgc cgccggacac 133740 tttgtctttc attacattct tcagcgttga caaggatggg aacctggcga ccaacggagc 133800 gcaaatgaaa ctgtactctt atggtggtga ctttacaatt accgaggtcg tgttgatcgc 133860 tgagcaggtt gtcccactct atatgactag tatttgattt gttcaatgag aataaggggt 133920 ttaaaattta accgtttata aaccccttca ttgatttgag gaaacaacat gcgtaatgtt 133980 acgatttggg attacaacga tgtcgtttgt gacctgcctc catttgctcg cctgtacaca 134040 tacaaaggga acaaacgtac tctgaatgag ttcttgtatc cggcatatat ctatcgggac 134100 gggcatcttg ctccgcgatc acttgaagaa actggtgtgt gtactccttt tgatatcaac 134160 aagaaagggc aagcggtatt cattggttat tccagcgaag acgacatggt aaatggtcga 134220 cgcggtctgt atatggtgtt caatacattt gagcaagccg tgaattggtt attcaaaaat 134280 ggttatgatt tctatggtga agagagttct actgctcgcc gccgtaaagt aaagaatgtt 134340 gatttctacg cagagcgcaa gaaatatctg gatatcgctc atcaatatga gcaatctaag 134400 aaatccgttc taatcaaacc atgcgttacg gtcggtgaag aagtgagtgt cgtggacaat 134460 tcctatttgg atcaggcaat taaatctttg aagccaactc ctctggccag tggtgctccg 134520 gttgttaaac atgacagttc aatcccgaca ccgcctactc ctccggccag tcgtgttctg 134580 aatgatcagg gcgctccggt aaaacaaaag gtcgagaagc cgactttcat ggataacatg 134640 atgaagttcc ttcgtctgtt caagaagtaa tccgagattc tccttttcta tactcctgta 134700 gatacgctat gataagccaa tgtctacagg agaaatagaa tgaacaaaac catcttcgat 134760 actctttccc tcaaccgcga tctggttcat tgggaagatt atctctacaa acacaccccg 134820 tgcgaactta ttgccaatcc agaaaccaat cagcaggttt ggttcaaacg tgaagattac 134880 ttcgcgcctt tgtcatgcta tatgaatggc aagcaaggga tcaatggcag caaactccgt 134940 caggccatct ggctcatgat ggagcatctt aaagcgggag gatccccaga tcttatccat 135000 ggtactgtcg ttggtagtcc gcagtcccct atggcgacgg cagtctcacg gcatttcggc 135060 ggcaagacaa ccactgtgct gggtgccact aaaccaacca catgcatgaa tcatgatatg 135120 gtttcaatgt cagcatggtt tggtagtgag ttcaactttg ttggatctgg ttacaatagc 135180 accattcagc cgcgctgtaa gaaactcatt gaacaattaa atccaaaggc gtattatctg 135240 gaatatggca ttacattgga tcataccgtt cattcaccag aacgcattgc tggattccat 135300 atgctgggtg gtgagcaggt tgccaatatc ccagaccata tcactgatct gatcattcct 135360 gctggttctt gtaattcatg caccagtatc ctgacaggtt tggcgatgca tccgaaacca 135420 aatctgaaga atgtctatct gatcgggatt ggcccaaacc gattagattt cattgaaaat 135480 cgtttgcgca ttatcggtaa acaagcaaac ctccctcaca taactgattt cactcgtcgc 135540 tatcacgaca acccagatta tgtgtatggt aagaaggatc tccagcatgc ctctaagagc 135600 gtttcgctgg ctggcctcct aagtggtatc aggccaaaga acgagccgga tatcgtgctt 135660 cctcgttttg aggtacacca ttgggatctt cataccacta attgggttcg ttacaacgac 135720 ctcatggatt accagtgggg agatattgag ttgcaccctc gttatgaagg gaaggtgatg 135780 acatggatac aggaacacaa accagaattg cttaatgaga actcattgtt ttggatcgtg 135840 ggtagcaagc catatctgga agcgatgaaa gctgcttgtc ctgaattatc aatacctgaa 135900 catgtccctg tgaatgagtt tgtccccagc taatccatcc taaatacccc atacgaccag 135960 tgtggggtat ctatgaaaac ctttctagaa ttttatcgcg aatcaacgtt acctgatttt 136020 acgaatatcg ttttgtatca tgggtctaat gttgaattcg atatctttga ttttgaaaaa 136080 tttggccaga ctgactctgg tacgatgggt gctgggtttt acctgacggg ggatccagaa 136140 aaggcacaga tctacgcaga aaatgccgtg cgctatcgtc aatctggtga acctattgtc 136200 gtggcatttc gtgtcaaggc caagaagact cttgtaatag attccaacaa tgtttcggtg 136260 tgggaaaata aaatgcgtga gttggggata aagcctggta agatacatga taatgtgaaa 136320 gaacttatca acaaagggtt cgattccata gcctctatga gtgccaataa cgttgaggaa 136380 atggtggtgt ttaagccagg gttggcgacc agagaagcct aaatagtcca aagcggttta 136440 ttcaagagga cattaccatg ccaatttcga aattatttga agcggattcc ccagcagaca 136500 tgcctatctg gactggtgtt caagacggga ctacgattga attctttgag cgcggggaaa 136560 caggcgctga agagatttat gcttccgtgc aagggacaga cgtcgtccgc gccgccgtag 136620 ctcttgctac atttttagag gacgccccga ttgacggtat cccgtttgaa gcccatgtgg 136680 acccagaaga cccgacgtct atcatcatta cagtccaggg tgctgaatat acatcttaca 136740 gtattgagca cgatgaagaa acaggggcgc tgtttatagc cacggatctt cagttggatg 136800 atgaagagat cgaatacctg aagcaaaatg gacgtctccc tgaatattct gatgaagaat 136860 tggattcagc gtttgacaac gtagacgatg atgacgactt ttgggatggg aaataaacaa 136920 aggggcttaa tgcccctttg ttttagatat cgtttgtgtg tactgtgaat ctcattgtta 136980 cgacatctgt tctttcatcc ttgtgtaatt cgaacttcaa accttccttc agaagactcg 137040 ccgccaacaa tgttttgaac ttttcgactt gcttgtctgt tgggtatttt tgagacttat 137100 atgcctgttc aaatgctgtt aatatttcgt caaacctgtg gccaccaaca gcgtacacca 137160 tgtcatcaat ttcaactccg cgatttgctt gggaaacgag ttgcttcttc attttgcaaa 137220 caaagatatc aacggctttt tcaactatcc ccatggcttc ccaaatctga gcctggtcaa 137280 tcgtagtctg taattcttgt gcgaagtttt tcatcatttc accttcctcg ttggatattg 137340 gttaaagagt ttgcccagct tggacacatt gataatcgtc tgagtcttcc agcgctcgat 137400 cccctctggt gtagtcacgg ttaggattga ataaccccat atatgggaac cattcagcac 137460 agccgcgctg tgcccaccaa ttttgtcttc cagtttacaa atgaaagact catattgcat 137520 cgcagcgttt cgacgtgctt ctttgacaaa cagagcatgg cgctcaggat cagctttgac 137580 aatatccggc ttcccaggta tgtaagaagg attcactgcc tgggtcaaag aacggtagag 137640 cgcatgtttt gatttcattc gttggtaatc tggatcacca aacttgacac caaccgaaga 137700 tggccacgga gcgcacttct cgacgtccca gccgttggat gccagatcgt ccattatgtt 137760 cttgatgact ttgttcgcgt actgctcagc agcattctca gcatcaacca gcagaggctc 137820 gacggcaata cggacaggag tttttggggt gctcatgata tagtccttca ttcagacaga 137880 agacgggcgc ggacataacc caggatgtac gaaaccatac cgtacagcag gacagtcagg 137940 tcactgggga ttaggtgata cttgccgatg tcggccatgg ccagaaatgc gaatactacc 138000 cacacgataa aaatcataat atagtccttc agttcaaagt aagcccccga aggggctttg 138060 tcatattaga ggcgggaatc caaccatgcg ttcttttcat tctgccattc ccaagcggcc 138120 tgaccaccag ccatgataac ttccagagaa ggagtattgt catcctcgcc gccgtgaaga 138180 tctggatcaa atccatcatc ttccggatca tcttcacatt cgttctgata tgcggaatat 138240 tcaatataat gcgcttcggc ttcgtaatcc atgtctccca gagcagtctc aagagtcatt 138300 ttaccttcgg caatcagctc agccgttgcg tcgtccagac ctgcgtcttt cgcttcaacg 138360 aacagttcgt gacgtttctg gaagaaaaag aattgcatgg cggcagaacg tgaatcaaag 138420 aattcttgac gaggagcagt gatatcacgc ccatcaattt tacttaccat cacgacacga 138480 gaaccgtact caaccaggaa gcgaccgcct tttacggggt tgctgccgtc aactgtgccc 138540 aaagtggtga ttacacggcc ttcttcggtg ccgaacaata cagttttgcc ggatttggat 138600 tgagcgataa tttcgattgc catgatgtat ttccttctct tcagattgtt gtttgttcgt 138660 actacaatta gaagtatacg ccagttattg aagaagtaaa ctttattcaa taaatatttt 138720 aataaatttt gaactctgct cctttgtaca ctgctgtccc tcgttctatg aggccgtcgg 138780 ggacaaccac ctttgtgggc catccgccgt ccggtgcttt gacagtcagg cgtgtcttat 138840 gatcacccag ctgaatctgt tcgtaaatcc ttcctctcac tatcgtcgcc ccgccttggg 138900 tgacgagcaa tctcttgttt accactttca ttccttaaca ccaaaagaaa ggggagtttc 138960 ctcccctcta acttatttct tcagatcagg ccacgcacca gaggtcgcag tagacccagc 139020 tgggggagca gactcaagat cgggagaacc cgactgagta acaacagtgg gatctttgtt 139080 aaccactttg accccaaact gcttgagagc atccacagct tgcgccttcc ggctgttgct 139140 tttgtaatgg ttatacccct tgataccgaa tgatgcacta attgctgtca ataacgaata 139200 ggtataccat tcaggtgcgg tatcgagcgc ctggaggccg ccgattactg ctttgatgaa 139260 atccccttta tgatactcat cagggaacag aattagttcc acaaccggag cagtcatgac 139320 gaggatagcg ggtacggcca acacgatagt ccagaattcg tctttccaag acccgccgac 139380 ttcggtgatc ttagacagct cccaatctga ggaggacttg atagcctcca gcttgacatc 139440 gtgtttggcc tgaacaactt cccgcttgta ttggatcaaa tcagtcccga ggttccagag 139500 ttgcttgagc gcccctggga tcatactcac aaaggggatt gccataataa actccttggt 139560 cattgaacgt tcctcggcta aattacgggg acgtgctaac ggcacggtta accggagaca 139620 aacaatgact gttttctata cgaacgttgc ccgacagggt aacgaccttc tgattcgtat 139680 tgcagacgac aacggcaatc gccgtatgtt gcgtaagaaa ttcgaaccca ccttgtattt 139740 acccacagcc gattattcca aagttgaaaa gattggcctc ctcaatgaac cgttggtgtc 139800 taaaaaattt gcgtcaatgc gtgacgccga caactatctg gaggaatata aggaggtcga 139860 aggcgctgcc gtttacggac aaacggatta tgcatatcaa ttcatagcgc atagttttcc 139920 tgggatgatt acccccgatt actcaaatat tcacatcgcc aacgtggata tcgaagtttt 139980 ctcggctggg tggcgcgatg gagaaatgac taaaggccca tttcctcacg cgacgattga 140040 atcccacacg tttaagggga gcgaggcgcg tgttcgccga ttccataagc aagtgttggc 140100 caaccatgat ttcgttcgag agcacttccc aggttccttt atttccaaca acgtgactga 140160 ccagttccct atcattgata gtaatggtaa gatcacacag aacatgaatg cagccttccc 140220 tattacgctc atccagcttc aagacatgaa taccaacaag ttctatgtct ggggtatgcc 140280 gtgctctaag gatcgccata aattcaaata tgatccaaat gatgaagaga taggtggtct 140340 tgaggttgaa tacaaagaat acacgactga acaagaactt cttcgcgcct tcttagatta 140400 ttggtctgaa cgtcaatttg atggttggac tggctggaac atcgaaacgt ttgatagccc 140460 gtacttggtt gaacgtatta cgcaggttct cggcgaaacc caggcagagc gcctcagtcc 140520 ttggggcaaa ctcaagaaac gtttcatcaa agaccgtaaa ggcgacgtga cttcttatca 140580 attcgtgggt tgtcctatga tggactacat gcaagtttac aagaaacaca cgtacacaac 140640 ccgcgaaaaa tactcactgg attggatcgc ttattgtgaa ctcggtgaga agaagttgga 140700 ttatagtgaa agcaagtcat tgtatgatct atattttaat gattattgca aacacacccg 140760 atatggtatc aaagacgtca aactcgtgtg gcgtttagaa caaaagctgc gtttgataca 140820 gttgatgttc gtattggcgt atcgcaccaa atctaactat gaagacggtc tggggactgt 140880 agcaccatgg ctggcgatgt gttactatcg tctttatgaa aaagggattg tccctaaaat 140940 acagcgtgta tatgatggtc caacggactt tgaaggcgca tatgtcatgg aggttgcacc 141000 agggatatat ttctgggtat tctctgagga cttaaactcc ctgtatcccc acatcataca 141060 gcaatacaac cttggtcctg agactatcgt ttctgacaag cacacacgtc gcgatatcat 141120 tgagtccatg tgtgaggaat taaccaaagc gatgaatgat atgacaacgc ctatgaacaa 141180 gcgccgtcat ctcaaaaatc ttcatgacaa gctgcagcgt gctattgatg aacgcataca 141240 agttgttgat gaattggtcg cgctgggtga attccatttt gaaacgttac gccgttataa 141300 cgtttctttt accccgaacg ttcagttctt cagtaatgag aagatgtcct tcctttccga 141360 aattatgcga ggcatatacg ctgaccgtaa aggcgagaaa gcaactggcc tgaagtatga 141420 gcaatgggct ggttggtgta aggaaatgtc taaaggtgat ttccaccttg aatctgccat 141480 gaagtctcgt ttctacgatc ctgaatggta tgaagaacac aagcatatcg accttgatca 141540 cctgactgaa gtcatgcata agtgggaaga tttgggagtt gcccaagata cgttacaaca 141600 aggtctgaag atcttgatga acgcaggata tggcgcaatt tctaacgtct ggtttaaaga 141660 atacttcaac atcaacatcg ctgaagcaat taccacttcc ggccagctga tcaataaatg 141720 gaacaaacgc cacactgatg attatctgaa caaactttgt ggtactactg gtcaggattt 141780 tgttatcgcg ggtgatactg actccaacta catttgcatt gaacgcctgg tcaagcaatt 141840 atggcctgat gaaaaggatc atcataaact tgttgataac atcgaccaat ggatcaaaga 141900 gaattaccag ccaaaaacca gtgaatgggc gcagttgttg tgtaatacca tgaacgggtt 141960 tgagcagcgc atggtctggg aacgtgaggt catcgcatcg tctgctgtat ggcgagccaa 142020 gaagatgtat tgcatggcag tatacgatag cgaaggcatc aagtatgaga aaccaaagat 142080 caaattcaaa ggtctggaag cgcgtaaatc tacaacgccg gaatggtgtc gtgagcgtct 142140 ggttaaatgc tatgagaaag tcctgctggg gacggaggct gaagttcagg aattgatcgc 142200 gggttataag aaggaatata tggaattaac cgtggatgat attgctcaag cctctggcgt 142260 tagtgatatt gagaagtggt tagacgcgaa cgggaattat atcagcggta cacactttgc 142320 tgccaaggct tgtattatgt acaacaagct gatcgataag cacgaagatc tcggtcttcc 142380 ccctatcgaa tccggtgata aggttaaaat catcaacctg aaacctggca atcctgtggg 142440 gaatgatcgc atagccttcc ctgacttcct tcctccagaa ttgggattgg ataaatgggt 142500 ggattaccac accacgtttg aaaagacctt catagagcca attcagtcta tcttggatgt 142560 ggttggttgg tctcataaac gtcgagttaa tctgttgtcc atgatgggca agaaaggttg 142620 attcaataaa ccaaaggggg atataattcc ccctgttatc cctttgacaa caggtattgt 142680 tatgaaactc aataagattc ttctggtgtg tgctctggct ttctctacca ctgcatgctc 142740 tacccttctg gacgttgcgt ctactgttga cctcgatgcg ccgacgttca ccaatcagca 142800 agcggtgaat aagatggaag acaccatcaa ggcacatgca gctttggaca acaccactcc 142860 tggtccgttg caaactgttt gcaattatga tgattccatc caggaagatg aaacctatca 142920 ctgcaccact tacgtgaagg aatcttctgt ggttctgtat gcagattgca cagaagagca 142980 atgcaccgca actggttatg atcaagtgga gaagtctgat gaataatcat gttggtctgt 143040 atgatgccaa ttctaaaatc ggtggaatgt atcgtatcct ggtagacgta gacttgactt 143100 tggttgatag cctctcccct tgggtggatt ggtttaatat ttccaattca aaagctgctg 143160 ctgaaaacat gggttgccat gattatccca atgatttcca gcgtatcacc aaagagtgct 143220 atatggctca tgctggtgat ttggcgatcc tcatgcggga acgcgctcac ccagcatggt 143280 tgacacgccg tgtgtttgtt gctggtcaat ggatggattc acctacagga cgtgatccta 143340 tggattggtg gcgcatgccg gacctgtatg ccaagatgaa cccgcttcca ggtgcttacg 143400 agttcctggt gaatctgaag aagatcctac tcgaagactt tgaaaatgtt gaattgatcg 143460 cagtatctaa gtgtgagcca gaacacgagc gcagcaagcg ccagtttgtc tatgacaagt 143520 tccctggcat cttcaacggg tttgtcagca ccgacgaaaa gcatcttttg gcaggtgatg 143580 ttttaattga tgataacccg aaatacgttg aaccctgtgc gatgaacaat atttttgtca 143640 tctttgttcc tcagggaaat tatgaaaaac tggatctttc gaactcggaa gatatgcttt 143700 atattaaacc agtagaaggc cagaaccact tcgacttcct gaaccgtaat attgtcgaag 143760 tggtgaatcg cctgattggc cattatcaat acgtccgttg aggaggacat cgtgcaagaa 143820 caatctaagt ttggggaaac cccagacaag cgttccggtg atagcgatat ggatggcgtt 143880 attatccatg tgaacaactt cattcgtaaa caaaccacac ccacttccgt tggtgcggcg 143940 ctggagttaa agcgtgttct gatagaaaac ggtatggcac cagatgacga tgaaattttc 144000 tataactttg aagaccagta taaagtgaag tttgtagaaa acgaacgtcc acaggttgct 144060 gttttctggt ctccctggtt gggcggtgtg agctggcgta ttgaggaaga tgcataatgg 144120 ctaaaataat tgtagtgaaa ggaacatctg gcacgggtaa aggcacccgt gttgttcagt 144180 tcatcgaatg gctccgcact aagctggagc ctactgaact cacctacacc attggtgaca 144240 agacgcgccc attcggcctg aaattcgaag agctgaagtt aatcttcgtc ggccagtata 144300 ccgtgtccaa caaatccggt ctggcttcct ggacttccat ggacgccatc cacgccgcca 144360 caggctcggg tgatatcgcc cgtgatctgg tcaaaggctg gctggctcag ggttacactt 144420 tggtgtgcga gggtgaaccc ctcatgctgt cagataaatg gcgtcctgaa tggatgttca 144480 agaactatcc gattgaatct ctggcgttgc tttattttgc atacccagac cgctatcagt 144540 atgatgcgcg catccgtggt cgctctggta aggaagcagg ggactccggc tggtcacgca 144600 acgaatctta ctccaaagag tttgagaagt cgaaagctga aatgctggtg ctgggttggg 144660 aagtggtggt caatgactac agcgggcaag acgtgttgta tcgccaatcg tctacaaaca 144720 ctcaagaatt caaaacagga aatgatagcg aattagccat gatgccgttt gatgcacctt 144780 tgtgggtgat tggcaacgct attcatcatc aaatgcgtgg tgagtttcac gccatgggtc 144840 tggacatcaa agatttctac ggattctgtg aaactgaccc aatgacgcgt gaagtcggtg 144900 gggatgatcc tctagcgcat cgagtccctg agaaggcgac caaatctaaa accaaggcga 144960 gcgccaaggg agaggtaaca aagtcctctg tatcccttct cggcctgttg agtaagggtt 145020 agaaatgaaa cagatgtcta aatattttgt gttcgtcgga ttggtgatgt gtatcacagc 145080 tgtgcttgtc ggtgtcatga aatatttggg catcgttgag ttggattcaa ccgaaatatt 145140 gaacgtttac gcgttatatt atttgggggg tgctatctta ttaacgcctt tcgtctataa 145200 cataattcag agtttcaaaa ggaattaaaa tgaaaatcct cattccacgc aacgttgtcg 145260 ctgttgctat tgattaccgt ggtgatgcga agatgattaa cgctgtccgt tattatccgg 145320 aacagaataa aatcgtccca caatttcaac tgaataccaa tccttcttct aaggatttcg 145380 gttcttggcg tcaggtgggt ttggctcgta cccaagtcaa tgcccagcat tttatttccg 145440 aaaagacgaa aaccgccaag caaatttggt tggtgacgaa tgatcgtcgt ttcctgccta 145500 tctggtctct gggacagccc gtagtaagcc ccgaagaaat tcatctggct cccgaagctg 145560 agcctgaagt tgtttctcct gtagaggaag cgaaagatga aaatcaagca ggttgatttt 145620 atcttcatga tgttgatgtt cgttatcttt acggtttcgc tggtcggcgt catggtcaca 145680 gaaggggtgc aacagcgccc attcttggtg atctgtccag tatcgatcgc cactttcttc 145740 tatctggcgt tccgtgttga actcgggagt aaaatcggat gatacacatt tctaaaatgc 145800 cgcagggata taaagcccct gaaaaatgga aatacccgat tgatctggca gtagattatc 145860 gtaagccaga aaatcgcatg tacctgctca aggcatgggt ggaggcgcta tcctacactg 145920 aagagcataa ccagcaagtc cgtctgatgg attatgccat cgaggttaca gaaggcatca 145980 cacagctcga aaagatcgag cgcaagattt ggatggcctt tttgtggggg tgttgctata 146040 atgggattgg accatggaca atttacagtg aatttcctgt acccccacaa tctccgaaag 146100 agtttcagcg attttctgat tggtataacc tgaactttga tcgtatgcgc ttcgatacag 146160 attgtcgtta tcgtaagtcg aaaatgattc cgtgcgttca gtcctatatc gattggttgg 146220 gtggtaaaac ccaaatggat tcttttcgtt ggatgttgga atgcactacc aaggaagacc 146280 agttcaccga actgtggaat acggcgatgt catggaaata cttcggtcgc ctgagcgcct 146340 ggaacttcct ggaagccctg aacatggtct tcggtaacat atgggatata gacgtccctg 146400 ggttcatgtt gcgtgaccgt gatggtagcg aatccaatcg taacggcgcg gcgttcttat 146460 ccaaccgtga tgattgggtg accaagcacg ggaagaaaaa gattaacggt tgtcctatta 146520 cagacgaaga atgtgatata ctcgaaaccg accttgagaa agcgtttcag gaatgcgttg 146580 aagagtttgg ccacatcacg tttatcaatc gtctgaactt tgagacctcc ggtgcttgtt 146640 ggctgaagaa attcttccga ctgaagaata cccgttacat cgggtgggac gccgagcgta 146700 catgggacga gatcgattat atggaacgta tttggcctga atactcctgt gcacctctct 146760 gggaagcccg ttcactctgg ctaccagata ccctgttatg tgagaaagct cctgcagggc 146820 acgttccagg cgtccagaag tggaagatgc ctgtgttctt tgagacgggt gttcctctac 146880 atatctggca tttacagcag ggcacacgtt gggaaccgtc tgaggtttgt ttgtcagttg 146940 gtaaattgga caccatgagc cgaaatggta ctgtgtatcc ttctaaaagt gtgaacctca 147000 tgacactctt gaaacgctga tataaatatc ctcgctataa agtgaggata ttatcatgtt 147060 acaagatctg ctggtttatg cgcttcctgg tgtggttgtt ggcttcatcg ctggcgctct 147120 ggtcttccgt aaacacgcgc aagacggtga agtgattgtt cagaagggta aagacatcct 147180 ggaacaaatc gaagccaaac tggacgagct gaagaaaaag taatctgatt gcgattgcgt 147240 tcttcaataa aggggaatgg gttattatta gcccgttccc ctttcttttt gcaaggattg 147300 attttatgac acctcaatac aaaatattgg tcaccagccg ttgttatgct tatggacagg 147360 gtgaagcaat atcagtacac acagttgtag ttgattttga aaacaaagaa caagcagatt 147420 tggcattcta caatatgcag cagagcacag ctcctgccga tattggcgtt aaacaagttt 147480 atacgaaatt atactgaggt cctatatcat ggcaatgcaa cgaattgaag acatgtctgt 147540 gctcgatatg gaagcgacat ttggcgacta ttttgaatct accccgaaac aagaaaaagg 147600 tcatctggta gtgtcggaag agttcgcaca aaaagttcaa gatacgcttc cgactaaatt 147660 gaacggtggg caaggcggtt tccgtcgcgg tgaactgaat atcatctgtg ccggagggat 147720 tacgagatga agcgccccga atacaaacaa tatttgtacg atctgttcat gaaagaaacg 147780 gatggtgcgc tccaccctaa gaaagcgact attgttaaat tgcattctga aggtgatttg 147840 tctatagcat atatccgaaa agaactagat ttgatgggaa tcgaatatga agaccatatc 147900 acggatacac gtgctttaaa aagagcaaca gcaatcgttc ttcataccgt tgcaacaatt 147960 atgcatcgcc accatgtttc ttttgacgat gcaatgactc cacagtatca tgaagaacgt 148020 tgggatctgt tgttgaaaaa tggggctaaa tctgagcata aaaatcaact tcttggtatg 148080 acgaaggaac aactcgtgga tggtgtgtta tgatttacct tctgtttgtg gttcctgtaa 148140 ttttggccat cttgtttgtg atatatcacc gaaagactca tgagccaaag gagactttga 148200 tcgccacggc cattgttatc gtattatctt gccttatcca gtcgggatta tatgctgctt 148260 tctcccttgg tagttctggg gacgtggaaa tcctgaatgg atatgtaact gataagcaac 148320 ggaataaggt gggttgtgaa cattcttatg aatgtatgtg ttattacaca acatcttgta 148380 caggttcagg aaataaccga tcttgtacac aaacgcgtca ttgcagcaca tgctatgagc 148440 actcttatga cgttgattgg gacgtattaa caaccgtcgg tgatctgagc attgaccgta 148500 ttgatcgtca gggtactaca gagcctccgc gttgggcaca agttaaaatc ggggaacctg 148560 cggcacgtga acattcatat atgaattatg tgctgggcaa caaagattca ttattctcta 148620 aatctgacca gcaattcgct gagaagttca aagagcatat cccttcatat ccgagggtgt 148680 atgattatta ccgagtaact cgtgttctga atatgtcagg gatggacatt cctgttgatt 148740 actggaatga ctatctgaac aatactctga aaacattagg tgcttcacgt caggttaata 148800 tcgtttgggt tgtgacttct ggccagcctg ttgaatattt tcagggactt ctatatgcat 148860 ggtccggcgg taaaaagaat gatgttattg tagtcaccga tatttcaaag gatatgaaaa 148920 ttaattgggg taagtctacg tcatttgccg acggcatgaa caacatggaa ctccattctc 148980 gtaacggact ttcattgact gggaaaccaa tgggcatatc cgtgttccaa gaagttgcgg 149040 tcaatatcag taagggatac aaccgagttg agatgaagga aatggaatat ctgaaatggc 149100 gagatcttaa aacttgggaa gtgattatcg tcgtgctgtt tggatgtatc ccatttaccg 149160 cagttttcat attaggccgc atgcagtaca atggtcgaac ttataaacgt ttgttttaac 149220 aagaggaagt aaagatgtcg cagcgtaaag gtatttcaat tggttggatc gttgggttgg 149280 caattctagc atttgctgta attgggattg gcagtgtggt tagctatttc aatgatttca 149340 accgcattga acaacaggtc aaaaagttca acaaagattc tgaaaaccac ctgagcaact 149400 acacgctcaa agttcaggag acggcgcaga ttcctgacat gtacaaaaac agtttgaagg 149460 aagtgatcaa agatactttc caaggccgtt atggcgcaga cggttctaaa gcagtaatgc 149520 aatggattca ggaacagaat attcagtttg attcatcttt gtacaaagag attcaggttg 149580 ttatcagctc aggtcgggat gaattccgca ttagccaaac taaaaaattg gacgcatgtg 149640 cgatctatga aactaaactt ggccagttcc ctggttctct gatagcagga atctttggat 149700 atccgcgtat cgatcttgac aagacatgtc aggtggtgag tgacacccgt acccaggccg 149760 catttgactc cggtgtccag actccgatta acttcaaagg ctgatcttat gagcgtgaaa 149820 ctaaccgaat ctctgacgct ggaacagcaa caggcgttgc tggatgaagt ggtaatctct 149880 gctgtcaagc agggcattat caaagatgac acgttgttga cgcgccccga aatgatccat 149940 catttggtgg tgtgtctggg cgaagccaat aatcctcgca aaaagattgt aatgttcaaa 150000 gaaggcatta tttatcccaa tggaagattc gcttggttaa ccctatcggg aagtcatccg 150060 gatttgaagg atgaacagaa agaaatcaaa acttctgttc cggtaacgcc atacaccgaa 150120 ggagttgatt tattgtcttg gtttgagact atcaatacca tctatgtcat ggcacctgat 150180 ggtaagccag cacaggatct gcgtggtggg gttgtaggtt cggaagacta atcgttcttc 150240 aataaagggg gatagggtat tattgctcta tcctcttttt tatggaatgt attatgtctg 150300 acaagccaag aaagattgca attattggag gaggaatcgg cgctcggact atggccatta 150360 tccttcaaga aaagctgaaa ggcgttgaag tagaatgtat cagtgtagac gatattccta 150420 aacgtcgttg tgaaccaggt gaacgcatga taatttgtga tgatctggta gaaagtgaac 150480 gcaaaacatt ggtatctcaa gcggtggctc agttacggaa ggcagatatt tcgtattgtg 150540 aagcagaagc cgatgacagg gacataattg cgtcacaacg ttatcaaaag ccgccgcgcc 150600 tatatggagc cgcccaacat aaacgtcagg ctaagaaata taaaaatcgg agtaaacgaa 150660 aatgactact caaaaaccga cttatgagga attggcacag accgttctga ccttcgaccg 150720 taccctgaag accctgtaca aggtactagg aaagaacccg acttcagagt caggcgaagc 150780 agttgatctt ctgttcctgc ccaactgcat ggtatcagct aacgccattg ttgccgctct 150840 gaaagataca ggagcgcgag agccggagcc cacagggatt cagaattatc tggagaactt 150900 tgacgagtac tccttcactg atctgctcct gcgcgatctg atcaacacag aacgtcgccg 150960 tcaggaaaag aactgccctg tagttcagtc tgaccatgaa atcgaacaaa ccgtccgtga 151020 agaactgaat ggcacctact cgcccatcga cctggctgtt atgatcgtaa aagctctgtc 151080 gtatgcagca aaaggagaaa caaatgtcta aaccattatc tgctgcggct gtagcaaccc 151140 ttgctttgtc cgccatggct gaagatatga cgcataatgg tcgtctctgg gatgatcatc 151200 gttatgcaca agggtgtacc cctggggaac ctgggcatgc tcgtccttcc gtcagtcgtc 151260 ctaaaaaggc caagacccat ggaaagaaca aaaagaaacg ccgtaaatga tgtcatcccc 151320 gaatatcgcc ttcacgcatt atcggaaggt gaacccagat catcacgatg tcatgttatg 151380 tttcaagaag gtaaaatgat ggccgatgaa atcctcttcc ttcgagcaga ggtgatccgt 151440 ttaagtaaca ataaaccccc aaagaaatga ggatatgtca tgagttctat tgaacagctg 151500 atcacaccac aatatgttta cagcaatatt gtagagcacc tccgctctca attgaatgtg 151560 aagcagttga acagctctga attgagtggt ttagaaataa cagaagttga agttgcggcc 151620 ttcggtagtc gttatcattt tgttgtcaat cacactcagg ttgaacaagt cacttcgagc 151680 attattgacc tcggcgcaac gaagccttcc cgcgcagagc cgaaatctgt gacacgcaat 151740 attgtgggtt atctggaaga gacgttagag ccaggtgcca cccacccgat attcaatttc 151800 aacgccaccg ttgtaaacgt tcagggaagt taatcctgat taaagcctcc gattggaggc 151860 ttttctattg agccacccgc cagtatcata accttaccca ataatgtgtt cttctttgat 151920 ctgaacagga attctatact atgaaaatgc gcaagtccga gcatttcgtg cgctcttctt 151980 ctaccatcgt cggacagaca ttcaatgtca agatgacgga taaattattt gaaacattat 152040 tttcaagtct ctacaaatat aaagaggcgg cgtctttgcg tgagacgttg tgtaatggta 152100 tagactcaca taatatgcgt gatcgccaac aacgctggat gccatcgcat tatgctcctc 152160 tcactcctat gcctcaacga tacagcaaac atcttgcccc caagggaact cctgttgttg 152220 tacatttacc ggatgttatg gaaccctggc tggaaattaa agattatggg gttggtcttc 152280 cattagaaat gatcatcggc gagcctatta cagcgcgtga agatgaagtg ctggttgaag 152340 gtaatatcgt cgtgaaggaa gacgaaatcc ctgatagcac tgctgttatt ggtacacctg 152400 gttattataa tggggtactg gtattccgcg ctgaggatgg cgagatcatt cgtggtcctg 152460 gtttgtatac aacactcttc catagtacaa aagaggacga cgacgggcaa ataggggcgt 152520 ttgggctagg ttctaaatcc ccatttgcgg tatctgattc atttacagta gaaagtcgct 152580 atgaagggaa actgtatcgc ttcctgatgt atctgaatgc ggacagaatc ccaactgtag 152640 atctcattac caaggattta gatacccgtg atcctaaacc ggaagacact gatgagttca 152700 acggcctgac tgttaaagtt cctgtaaaga atcagcgttt taccgccttt gaacaagagt 152760 tggtccgttt gggtcgagtg atgcgacctt caatgcgacc gaaggttgaa aacgccagtt 152820 attctttccg ttggtctgac atcaacttcg aaaaccgtgt aggcaacacg tatattcagc 152880 cgaagtcaga ttccgacaac atccactatg ctgtcatggg cggggtttct tacccgatag 152940 atctcgacca attggactct gaaatatgca ccgtgctgga aaaattcccg agttcctata 153000 ccttcttcga acttggagaa ttgaatgttc ctccatcacg tgaagacttg tcatatgacg 153060 agttcacccg tgaaagcctg aaccgagtgt tcaaatatgt ggctgacaat attatgcagg 153120 cgaagatgta tgaacttcgc caggccgaat ctatgggtcc tcttatgctt tatatgaaga 153180 aggctcaatt gaccgatatg ttcggtagcg gtttccgtaa attagtggag cgagaatttc 153240 ctgcagataa ccgtttctac aaaggcacgt tccgttatat cggagcgccg gacgtcgtgc 153300 gcgattactc tttggatgca cctttccggt ctattggtag tccttacgaa attgaagtac 153360 acgacaacgg tgtagtacac gacagcattt atgtgaactc tgtcggaaat tggttgaaat 153420 ctaaatcaaa aattgctgtt attattgata actcgaatcg tgctcgaaac ctgaagatac 153480 aaacagcacg caataacttc aatgtcgtta tcgtcgtcaa accgaatgaa aattatttca 153540 gtaatcggaa tcagctggcg gcacataaag aatcatttac caaccatgag gaattgaagt 153600 cttattttga atcatggatc ggtgtacaag aaacaacgcc ggactacctg gtctttgccg 153660 ataaactgat cgaggtcttt ggcgatttat tcaatccgga tgaagtctat ttcatgcatg 153720 aaatggaata tgttcgcccg accgttgaaa aagatcctgg gatgtttagt ttccattaca 153780 attcatttaa cttcgaccgc gtttatgaat tagatggaaa aaccgtttca gatattattg 153840 attcgggcaa aaagatcgta tatatcgaag tatctggccg agaaggtatc cataaaattc 153900 atggtaatac cttacgacaa tccgcggctg gacatttgcg tgaagcgatg gaaagaacga 153960 agttcggcga gaatggaaac gaaaacctgt ttgatttgct gggagcacat ccaacaatcg 154020 ttcttgcgcg tcgtaaatct gttccgatga tgaagaaatt cccagaagta ttcatcccca 154080 ttgacgcagt gtttgatatg ttgcttgagc attataaaga tgaatttcag gcgcttgaat 154140 ctaagaaact cctgaaactt cgcaagggca taaacatcat gtctcatcgc attgattatg 154200 gtgccaagct gttgattgat tcccatggaa aagttacgga tggctatgcc catcatcaac 154260 acagggcaaa agcaatcatc agttatgcga aacaacaaat cactgaagaa gaatggaaga 154320 ttgttcgtat gctggccaaa cgaaatccgt ctggatcggg gtacggttat ttccgcaagg 154380 ctgttgagga attacattat catatagaaa tgcctttctc aactacgaga tttttccgcg 154440 cctgtaacca gttaactcaa gttgttgatt tattgaatga aaaattaact gctgaaggat 154500 ttgatgagat aaaggtcact agcactatat ctcaaaagca aaaggccaaa aaccgatacc 154560 gagttgaatg tcatcgtttg gtgaaattca tgatgtcaaa atatcagcct tcggcacaca 154620 acgcgattga agatgccact agatttgtga aggctatttc aaaacgtatt ctcggggcat 154680 aatagcccca ttaccccaca gtgagaacta caagatgaat gctatagaaa aacgtattct 154740 caagctgttg aatgagaaca gaagtcaaag ttcaatagcc agtgaattgg gcgtaccgcg 154800 ctcaatgata caacgcgtgt cggataaaga actgggagtg gatccagctt cgattaagtc 154860 tctgaccact gaacagattc aagaaataca aaccaagagc agcaaaggtg aaagcaattc 154920 ttctctggca tcagtttatg gcgtcagtgc caaaacaatt gcccgcgccc tgatggttcg 154980 tatcatcaaa gaatctaata acgtggtcgt gatttcgcca attaaagaat tgactgaaga 155040 agggaaaatc cccgacacct atgaagttct ggaaggttcg gtgtctgtcg attctgaagg 155100 cgaagaatgg tatgttggcc gtttcctgga aaaccaaaca gtgtttatct gtatgcgtta 155160 cgatagctct gctgctattc aggccaaact tttcagaagc gaagaactga aaccgttaga 155220 aactcggtca agccgcttca atgaagaaaa catttctccg ttggccgaat tggcgacagc 155280 actggttgat ggcgttacca aagtcaatga cggcgtggta atcagtgtac aacatgacgg 155340 cgaaacatac ccgatgcgcg gttcccttga tgcccgtcgg cgtgtgggat actttgacgc 155400 aattctgggg cgtacacttc gactggcgtt gtcgtctgtt gttttctcgg ttaagacaac 155460 ggctgttgag gaagagtctg gcgacaaaca aactcaaaac tcatttaaag aaaaagatct 155520 gtcagtgttc ttgaatgagc accagatcat gattttaccg gaaagcatcg ttatcgttat 155580 ggatggcaaa ccggaaacga taaccacaag ccatcaggcg tatgatcgta ttgttgaagc 155640 gattaaaaat cgtgacgtca aaacagcgta cactctgatg aaaccgcgtg aagccatcag 155700 caaattcact acaggcatgg ttgatttatc tgacaaccgt gtgcgctggg gtggctatga 155760 catcacggga acttccgtcg ccaaacgcgt tttggcactg gcattaaaag gcgattatcc 155820 gaacttagaa cgcttgggtc gttttctgga caaaatgttc caaaacccga gcgcggcgct 155880 ggttcagtcc ggtcgaatct atgaattcat ggcatattcg gatatcgaaa ttcatgaaga 155940 cggtgatatc atcctgtata aatccgttcg cggtaactac atggacaagc gcacaggaaa 156000 agttagtaat gctcctggca ccattgttcg aatggctcgc tcatttgtga acgataacaa 156060 caaagatctg tgctcttacg gtcttcacgt ttgttctctg gcttatctga aacaatgttt 156120 tggtagcctg ggacaacgcg ttgtccgttg caaactgaac ccgaaagata tcgtgtctat 156180 cactgatgat tatggctcca gtaaaatccg ctgctgtgaa tatctggtat tagacgatta 156240 caccacggaa tacaaccgcc aacataaatc cattgatgtt gaaggtctat acaagtaagt 156300 gtaaatggat ataaaaggga ggcttcggcc tccttttctt tgaggtgaat atggaaacta 156360 gagatgttta cttcgtgtat gaacaacaag catttggttc attacgccgg aaaacaaaat 156420 tccttgttga ttcattccaa tttgatggag aactcaagga atactcgttc aggaattttc 156480 ctccgagaga agtcataggc gaccagttcg tgaaattatt ttgtcgttgt ggcggctgtg 156540 actttaacga cgacggatat tccatgcatg tttattgctg caatt 156585                          SEQUENCE LISTING <110> Optipharm.CO., LTD   <120> Novel Salmonella specific bacteriophage SP1 and antibacterial        composition comprising the same <130> 30 <160> 1 <170> PatentIn version 3.2 <210> 1 <211> 156585 <212> DNA <213> bacteriophage <400> 1 gttgtggtaa atatattaca gtctatagga gaactgatca tggcgaagac acaaaagaaa 60 attgaaaaca ctcaaaccat tcaagaaatc actgcacagg aagaaaataa acttcccagt 120 tatctgcaac gcgtggtgga taacgtgcct cagggcggcg acggcggtat tgtctacgct 180 ggtgactacg gttgggtgtg tgaatataaa gacggctcta aggagcttct agaggaactc 240 accggacttg ccggaacttt gcgccgttat gggttagata aattcggtaa acctatgaaa 300 ccaggtactg tggtatcaac cgatattaca gttgaagttc ttcttttgct tgatatcaat 360 gatcttaaga cacttgcgga acccctgggt atcgacgcga ctgaccgtaa tgaaataatc 420 tcgcaattga ctgaaaaact gcagattaaa taatcccagt gtataactgc tgattataat 480 tcaatatggc tatcgttgac gaaagcaatt tgatggagta cgctctaaga cattatatca 540 cccctggtgt ctcaagagat gatttgatgg tagacattca gcgaatttcg ctaattaatc 600 aatcattgaa aagatttgtg ccagggaaaa gtcctcgcgt acttatcaat caattgatta 660 ttcttttcaa tacctttgaa accgaagccg tgtgccgaat gttggtgttg aaaacggata 720 agaaccaaca tcctcgtctt aaagcagcgc tgttgacgtt aggagtttgg cgagatgatt 780 tatgttccgg ttcatacgaa ccagataatg agctgatgat ggctctgaac aacgatttgg 840 atgagtggag gaaaccatgc caacaatcac agtattagtc gcaccggaag ttgtccgcaa 900 caaacccgaa accgaacgca atcatgtcgt gacgggtgtt gcaaagggtt ggcaaaagac 960 cagcctcaac caagatcctg acgagatcct gaccgaatgt aaaggtcttg acgctctgct 1020 caccaagagc aatttacaag cggacggtgt caccaaagtg gatcccacca agcctatcgg 1080 ctttcaagta tcttatgaaa tccacgatcc gaatgccatt ttaaccaccg gacttgtgat 1140 tactccagct acagccagcg gagagatcgg acaatttgtt gaattgctag cgacggtatc 1200 ccctgccaat gccacatatc aaggcgttaa ttggtattct ggtgatatta cgaaagctgt 1260 acatgtcggt ggtggtaaat tcaaattgct ggcttcagga actgtaacgg tttatggtgt 1320 cacggttgaa gggaatcaca cagattctac ggttattaca gttgcaggcg ctctatcgct 1380 gtcgactgat ttacctgcca ccaaagacgt aacttctgga caagacggaa cctttagtgt 1440 tgttgctgcg ggcggtacaa ctccatacac ttatgtgtgg catttctctg atactcctgg 1500 gggtgctggg tcagttatcg atgctggcac taatgccacc gccgccactg ctaacctggt 1560 tatcacagca gttgaagccg caaatgaagg cgaatattgg tgtgtggttt ctgatgcaga 1620 tggccattct gtcacgtcta ctcgttgtga aatggctgtg gtgtaattta tgaagagctt 1680 ccaggatttc cttgaagact cttctgctcc ggcaaccacg accgccgatg tggggaaacc 1740 cgaaggcggt atggtcaagg agcctgtcaa aaaaccaaaa gatcttgaag aagagtctga 1800 ttttaaaaag atctttggca acattttcaa agatttggat ttatccaagg cgcgaaaatg 1860 gaatttcagg acaggccaat acgacgatta aagaggcttc ggcctctttt tcatttccag 1920 cattgggtgt ataatggacc cgttccccat gagcggaacc taactgagga tataccaaat 1980 gcaatctatg atcaaacgta aaatagaaat ctctatgaat gcccatgtcg atatgatcca 2040 gcagcttgtg gcagatgcgt atgagataca aaaggaacgt cagattaggg gagtgataga 2100 ccctatttgc tccggcaaca tgctctacta cagaatgctc cgccagaccg gacatacagc 2160 cgctctgaag aaactacttt ctaaaaagtt tcaggtcgaa aacgacgcat atgtgtttgg 2220 cgtcttccat acttctcgtg aacgtgatgc attcttctat ccttcccgca accctcagac 2280 gggcgaagaa ttacttatcc ctgatgtcga caagaaagag agcacgacga caatcaccca 2340 tttcatgggg accaggatcg ataaggctaa cataatcgtg ttctctgaca ctctacatga 2400 tgtaaaacgt ttagccgctg cccgtgaaat gttgcaggat gctcggacca gtctcacaaa 2460 tttgacttta gtagtgtttc tgggctagat atctgtgtgg ggagagaact ccccattttg 2520 aatcggaggt gatttatgtt acgttgcaaa agaggttcca actcctttaa gttgggcatg 2580 ctgactggag taacgttcat gattgcttta gacagccttg tgggactgct ttccctacct 2640 gattttagga tggaacgatt catattgtta gttctatttg gcggcgtctc tattatctgt 2700 accctgaaag catataaaaa gatttgacct gattacacac agcaattttg atttgagacc 2760 ctatatcatg ctcccattac tcaatgttcc aaaagaacgt atgacgccgg atagtgaagg 2820 caagacccat tacaacatat acagtcgaag ccgcacagaa ctaggcagat ccctttccca 2880 ttttgcatac catcccatgg atactgttga tggtaatttc aactcaatag aaggctactg 2940 gtattggcta aaatatcgcc acgacgactt gcgtagtctt tatgggaacg acgccaagca 3000 atttggacaa accctggcca agtcacgcat cgttgtattg tcccctgatg atcccaaatt 3060 taaaagagac attatcgcag cgacgagtca aaaattgctg acaatgccat ccaagttgag 3120 attccaattg gctcacagcc gtcttcccct gattcacgct tatgaacatc aggggaaata 3180 cagttttcaa aactctatgg attttatcat acagcatatt aaccgcttcc gtctagaagg 3240 atatttgaaa tgaattttct aaaaactatc ttcaacacat catatgaact cagccagcgc 3300 gatcctaatc gttctcctgt gtttgtatat tgcaaactcg tggaagagtc ttgtgaacta 3360 tcagatgtgc tttatggaat cgctgcatcc gaacccctga acggtgaagt ggcggacgtt 3420 atcatctcgg ctctggatct attatatgtt gtggattatc aacaagttca acaacatggg 3480 tctatgacca aagaagaaat ctttgactcc atgttgtttg ctttggctac agccaatcac 3540 acaactgatc tcagccaaca tacgttggag gattattggt tctgcagtgg tgttgaaact 3600 atagacaaat atcttgcgat ggttaatcat tacaaaggcc gcatcactcg tttactgaac 3660 caacctcaac gttcggaaga taatatggtg gacctggttt caaatctgat acgcaatact 3720 gccaaattgg cgtgtgggta taatcaaaac catatcaaca cgatcgttaa agtagaacat 3780 gccatagaac acaaagttga aaagtggcgc actaaatttg gtctataagc caaccccata 3840 cataatcttg tgtgtttacc attgacggga taggccgatg tccaacaaaa ttgatattga 3900 acgcaaatac aaaaagctca ctcacataga gcatatccta cttcgcccag agcgtcatct 3960 gggcagtatt cgttcgtctg tggggacggt gtgggtgtat gacccaacca aagacaaagt 4020 catctttcgt gacaactttg agtactcccc tgcgctgatc aaacagtttg atgaaatcat 4080 caccaactgt gttgaccaca gcaagacccc tgagggtaaa ggcttgacgg aaatcaccgt 4140 ccggtctcc cctatgaacg gtcaaatcat cgtttccgac aacgggggta tccctgtggt 4200 caagcatggc gtcaccaatg agtggctccc tgagatgttg tttggctcgc tctatgcggg 4260 cagcaacttc aacgatgagg acgaggagta caacaaccag aagtccggcg gccagaacgg 4320 tgaaggggct tcgctcgtca acgtgttctc aaagtggttc cgcgttgcta ccagtgacgg 4380 caagaagtct tatactcagc tgtttgaaga caacatgagc aagaagtcca atccggtcat 4440 cggcaataca ccgaaagagt tcggcaccac tattgcctgg atccctgatt atgcgcgcct 4500 gggtgttaag gggcttgacc agaacaacct gctcatgatt taccgtcgtg cattcgaagt 4560 ggcggcatgc aacccgcgcc tgaaggttgt tctcaacggc aagcaaatcc gcattgatcg 4620 atttggtcat ttcgttgatt acttctacgc tggctcggct gttgatgaaa cggatgattg 4680 gtctgttgct atcactccct catctggtgc gttcatgcat gcatcatacg tgaactcaat 4740 cgccacgcac atcggtggac ctcacgttga ttatgttgct gaccagatcg tggcggcgat 4800 acgccctcag ctggttaaga agttcaagac cgaactgaag ccagcgatga tcaagaacca 4860 catgtcattg ttcatcgccg ccgacatcaa caaccctcgc tttgacagcc agaccaagga 4920 gcgcatgacg actcctgtga gccagtttgg tacgtcctac aagcccagcg ataaactgat 4980 tcgcaaggcg cttgagttcg tgacagcagg gctgagtaaa gaactggctt cattacgcaa 5040 tgaacaagaa gatgccgaat ttgaaaaggc gaagaaggat atcagcaaac gggattatcg 5100 tgagattgag aagtattatc cggcgaccgc cagaggcgac cgcagtgggt gttcgctgct 5160 actgacagaa ggtgatagcg catccaaccc tatcctgaac gctcgtgaca ccaagaaaat 5220 tggtttgttc ccgcttcgtg gtaagtttat caactgcttg aacgccccgc gctcaaaagt 5280 gatggcgaac gaagaattca agaatttatg caccattcac ggcggtgctg tgccaggcca 5340 gccgcttgat atcagtcgct atccacagac cgtcgtggca acagacgcgg atgacgacgg 5400 cattcacatc cgtgggttgt taataactct gtattgtacg ttctggcctg aatacgttcg 5460 tcagggtagg ctgaagctcc ttcgtacccc atacatgcgc gtgtggtgtg gtaatataat 5520 gcatgaattc atgaacaatg ccgaatatga ggagttcctg aagacacctg acgccaagaa 5580 gatcacgaag aagaaatatc tgaaaggtct tggcggtaac agcactgaag acttcaagcg 5640 tattctaaac aacctggatg cgtatactac gacggtcacg ctggacgatg gatacaagca 5700 gtcactgaag aatggcttcg gtgatgaggc cgccgattac cgcaaaacct ggtttagcga 5760 cgtttgcctg tttgaaaccg aggatgaata agatggttgc caagagcatt actgtaacgg 5820 actttgtcaa cactgaccac aaggagtttt ccgtggtcaa cagcatccgt caaatccctc 5880 agctgattga cagcctgaag ccaagccagc gcaagatcct cttcgctgct cttgaataca 5940 acaaggagga gattgttgac cgccttggca tgttcgccgc cgctcgcacg aattacaaat 6000 ccggtggtga gaacatgagc ggtacgatcg tgaacatggc tcaggggttc ccaggtacga 6060 ataacatccc atactttgac cgcgacggac agtttggttc aatcatgggg cgcgaagcgt 6120 cttccgctcg ttatatttca gtggcagtgt ctgaagttat ccgtaaaatc ttccgaaagg 6180 aggacgatgg gatattggaa tacaattatc ttggggaaga gaaactggag ccgaaattct 6240 ttttacccat cctgcccatg tttctcgtga atggtatcaa tggtatcgga tcgggttatg 6300 ccaccgacac cccatgtcac tgcgttaagt ccgtgctcag tgccctgaga gcacttctcc 6360 gtgggagaaga cccgaaggac ttaaaaccgt actggaatgg tttcaaagga gagacaggct 6420 atactgagga aggaagagca tacagtcgtg gattgttcac ccgcgttaat gcaaccactt 6480 tgaacatcac cgaggttcct attggttggt tctctaaaac ctatgagacc aaagtgctgt 6540 tgcccctgta caaggcggga gtcctcactg agtacgccaa cgatacgacc gaagatggtt 6600 gggatatcac tgttgtattc aagcggggtg aattgtctaa gttgaatgac gaacaggttg 6660 aacaaatgtt ccgcctctac tcagctaata agcccgtgtg gacagcttgg gatgaagatg 6720 gtgttattca ccgttacgat ggttggaaag atatgttgct tccatttttc aattatcgcc 6780 tgagtcgcta tgaagataga cgtcagtatc ttatcaagga attgaccgac aaaatacacc 6840 gtttgaacaa tcgtgccata ttcattgggt gggctgtcgt tacagatatg cgccggagcc 6900 tcacggaact gaaagcgtta ttccagacag actatcctga ttttgatggc gatctcgatg 6960 atttattcaa gatgtcttta tcatcaatta cactagatgc ccgtgaacgt ttgttgaacc 7020 agataaagaa tttagaagtt caacgagaag aattaaataa taagcaagac atcgatcttt 7080 atactgaaga tttagatgat cttgaaaagg cattgggcct ataaatctgg agggtgaatt 7140 ccctccaaac aagcgagggg ttcaccatgt ttgtatattt ccgcagtctc tcattgctgg 7200 ctttcttcta ttggttgttc gatatcttat gccctcgttt tattaaagat gaagttgctt 7260 ttgtcaatca tgaaggtcaa caagatttat ggatacctct ttgcgctctt tctgatgtaa 7320 ccgaatcgga tgaagtgggt atggttggca ccatgcgttc atttaattta tttggattcg 7380 cattattccc taagttaatt ggagaattac acccatacaa tcctgatgaa gaagtggagg 7440 cgtgatatgt caaaattatt gactccaaaa ttattatcaa tgggtggttc catatatttt 7500 cattgtcctg gatgtaatat gcttcatcct tatcgcattt cagggcaaat gcctggccca 7560 atatggcaat ggaatcacga tctcgaatca ccgactttca ctcctagtct gttggtgaat 7620 cattctgatc caaataaccg ttgccattta tttttgacag atggtaaatt acaattcctc 7680 ggagattgtt tccacgaatt aaagaatcaa accgtggaga tggtcgatat tcctgaacct 7740 gaaatatgga tagattagat tatgaaatta cttggatatt ttcgttcttt acctactgga 7800 tctcctaatg ggtgtcaatt atactctgaa gtgaaagggg acgtgaacga cactcacatc 7860 gccttgtatg ctcgtgatat acctgaccct accaagtttg atcggcgtgt tgtggctgct 7920 gccaacaaat atggtgatgt gatcgttgta agcgcccgac atcacgacaa attgatgaac 7980 acgcaactca aacgattgaa ggaagcaggt attatcgaaa ccacccacac tcgtgaacaa 8040 gggtttattg ataactatgg gcaatggatg tcccgtgaag aggccgctgt ggtcgcccgt 8100 gaagccggac aaactaatca ggtccgtttg aagaacactc ctttcaaaaa actcttttcc 8160 gaagacctct attgaataaa ttggcggtat aattgccgcc taaccccata atgagacaaa 8220 taacatggca aatgaaattg gtgatattgc ccagttccgt gctatttcac gccgcctgaa 8280 atcgtatgga ctcgtcatcg aagaaataga tgaagatgtt cagggtgtat tggaagggat 8340 gtttgggagt accgttggaa cggaattatt tgaactttta aagatggcag ctgataacca 8400 atttgttgaa tatatttctg aacacgctat tgatggcctg aataaatgaa cgagttatat 8460 gaatttgaac gcgtgtatga gtccgcttca gtttcaggat acatgaaacg attatatcaa 8520 gaaatctgtg ttcgtttgat gatgcgagga atatctgtca attgtgttat ggcacagaca 8580 gacagtttta ttatgacact cactgaccat cgccagaata tgtgtatcat ccaggttagc 8640 tgtgtcaaca acgaaattat acaatggaga cgttacgcat gaccacatat gttatcacaa 8700 acggcgattt actgaaagcc gctacgagtt ttaatctcat caatgctttc gctcatggcg 8760 caaattgttg gtctgtgatg ggcgcaggta tcgccaacca tgttcgattg gatttcccag 8820 aaatttaccg cgccgaccaa ttagatgaac gtggtccgga acaacgtttg gggaacatgt 8880 cctatgcgtt tgatcatgac actggtgtct ggggattcaa tttgtatact cagttctacc 8940 ctggtcctaa cgcacgcatg ccttccatta tcagttcagt tcagattatg tttgaacaag 9000 ttcacgatat cattgaggca aaaactgacg aaacagtcta tgtcggttta cccgccatcg 9060 gctgtggtat cggtggtttg aaactgtttc atgtagtgag ccagattaat aaaatcgcgg 9120 atactatctt cgaagatacc aggcgtcgtg tagtacccgt cttttatatc cgacagggtg 9180 acgaggtttga acaagattta caagaacttt cccagatggt ggactacgga atctctgtcg 9240 tcgctagtga agaagatatc atcgaagagg aaggtattgg atgaagcgtg aaataacaga 9300 agagatgctc gccaaagccg ttcttcatcc caaggtgcgt tttgcattta tccctacacg 9360 tttacacgat ggaaattggg tatggctgga gcattacgtt cgcgctccta tcggcctata 9420 tgcccaactc cgttatggcg gcgaagtcga gttaaaacaa tatcgcgtcg gcgggggatt 9480 aggcgggttg gatgacgggg aatatttccc acatcgaaat ttcgccatga acgataattc 9540 atatttcaaa gtcgagtatg ccaccgcttg tgggacatat cctttgaaac tccttttaga 9600 gaaagcaggg gaaactgatg tataaatcta atttcttggc cgtcgctgat agcgaaactc 9660 tcggtcgttg ggatgatgct gtcatgttgt cttgggcaca gactatcgcc gacctgacca 9720 agcgttatac ccttcagcag cttgttgaag agcgcacgac atttatcaaa ctgaatgtca 9780 aagaacagat tgaacttggc cgtgtgaaag accagggcac tgtggaatgg tggctgggta 9840 caggtaaacg caacccgtgc gacgccgccc gagctatcag tctatatccg accgacaagg 9900 atatttctat tttcgaattg gccgatgaaa ttcgcaaggg atgccatcgc cttgggatcg 9960 acccgcgctc ggttgactgg tgtgatagga atctgtttga cctccgcaag gctcagcaca 10020 tcattgaggt gacgtgtaag caagattcca acgaaccttg ggactatcac cacacatttg 10080 acatcgtaag ctggctgaag ggtgttgggc agcaggatcg atatgctggt atcaaggcgt 10140 gggaactgga aggcatgatc tatcatgacc ctcgttatga tgcggcgctt gactggctac 10200 gcattcagaa aaccatggaa gacctgatgg ggctgaaggt agaaggatga atctttcctt 10260 gttttcatgg ttgtttacaa tcatagtttt cttcatagtc tgtgttcaat attttggagg 10320 ttcttaaatg ttctttcaaa ttgtcggggt gatcacgacc attgtttttg ttgtcataac 10380 gctttggata ttgtattttt catttatcca tccgattttt caggctctca gtattacgcg 10440 ttggctcaca gcgtgttctt tgaaatccgg aagcgaatgt ccttctttat cgtccaaatg 10500 gaaattcttc aaatgggcgt atgaagtcgg aggagtccga acaaccagat attcaaataa 10560 tgtaggggaa tggtttagca tcggcaattg gcgtttgtac gaatctgaag acaaataagc 10620 cccgaaaggg gcttttctat ttgtataatg tattatcatt gtaccatcat atctttatgg 10680 cacacaacaa atgaaagagc aagaaattat ccagcattgt attcgcttag gaacattaaa 10740 acctctctat caggctttgc gtttcaatgc cattaaattc aaacctttac caagaactat 10800 cgcaacgttc tttgccatgc gttctgttgg aaaaacgatt ttctttgagc atgacattta 10860 tttttataca aagattaatg gcgaagattt agataaaatg attttcgtga acgacgataa 10920 aaatatgaag ataaaagtgg aaaacgaatt gcgcaggata aatgattctt taagaggaat 10980 attttaatgg aaattgttgt ctcaatatct gattgtgatt ttgtataccg tgttcttcaa 11040 ggggatgctc cattgccgga gaataatcaa gaagtgacgt tgttctggtc tggtggggtg 11100 gatagcacat acatgttgat ttggttgtta tcgaaaggat attcagttca tactgtgtat 11160 tgccacctcg aaaataataa atttaaatct aaacgcgaaa attgggcgag gaataaaata 11220 cacaactgga ttaataaaaa tgccccactt ctcatgtatc gttggacaca tcatcaagaa 11280 cctatcagta gcatcaacgt cccgaacggt ggttttcgcg cttgtttagc acaagccccg 11340 atatggttat taaacacgca atttaaaggc agtggcttgc cttccacgta tatcttggca 11400 tatgttaacg gcgatgacgc aatacactgg atacccgcct ttaataaagt tattgaagga 11460 tacaacatga tgaccagaga cggggaaaga tctattgaaa ttttatatcc attgattagt 11520 ctcaagaaat cttggttcta tcatcacatg tccccaatac atgacttaat gacatggtgt 11580 gaattgccaa ttttgaaaaa gaattgtgat tgtcctgcgt gtgttcgaca tcgccatgag 11640 ttatcataga gatgaaacgt tcagttgttg taaatgacat cacgagattg ataaatctta 11700 tcaaagacgt cttcccacaa caggtggatg ttgagtatgt tgggaagaac ggaaagtgct 11760 atcaggttgc tctggttctg aagcatgtgt atcctcaagc agagatccat tatagccaga 11820 ttgaaggtca tgtgtatact ctgattgacg gacattacta cgacatcgaa ggcatccact 11880 tcagtgtccc accagacacg tgtttgctcg aacataatag aggtcacaaa ccgcatcgtt 11940 ggcataaagg gtttgtgaac gtgccgattt tagaatggct gaggaaacca taatggcggg 12000 aattgtaaag caccttggtg acactcatct tgggcataag aaggtcttta aaccgcgtgg 12060 atttgataca caggaagcgc atgacgctgc ggttatcgac acgatcttcc aggggctgaa 12120 gtctcgggac gtccttgaac tggctggtga tatatgcttc atcggggctg aagggttcat 12180 tcgcctgatg cgggagggtg ccaagcgaaa cattgatgag tttaagcgac accccgtccc 12240 cgatgactgg cgtccgaact ttatcatcag ggtggcacag ggcaaccacg acagctttaa 12300 gatgctgttg tctttgtata tggacggctg gattagctcc ttcggcgcta tgtacgaacg 12360 tgacacgcct gttggccgtg tgttgacaac acatgttcct tatcaattag accgttgggt 12420 gtataatatc catggtcatc ttcacgaaaa tattcgcgaa gagcgcgaat acctgaactg 12480 cagttgggaa caattcaagc gtcctgtaac cctggctgag ttgttataca caaatttagg 12540 aattgtgcta tgagaatatt ctttcctggt cagaaagtac ccgaagaaat agaaaaggtc 12600 gagttatttg gttataaaag cggtgatccg ttcctgcgat tttcttcacc atgtatcgta 12660 aagcgcaata atgaaggata ttatgtgcgc ccaatcattc tcatgggttc tgtcatgaca 12720 ctgagagctg aaacggattc ggttgttatt actggaagtc ccaacatacc caatggaaag 12780 actacgctaa attgcaagcc tatcctgtcg tcttggatgt taattggatt tctatctgta 12840 gtcctgtctt atcgttacct tactgacttg gggatcttat gaaaaagcca agaatcacag 12900 gacatcaact ctgcgtcctt ttaggaatgt taaattttga aaagggtgaa gccagacgcc 12960 tttgtcattg gtatttcaat ccgaagtctt ggacgaatga aaagggcaag acagtatgga 13020 cattccatac ccctccgatt gctggtgggt ttcgttctgt aaaaggtgat ccgtgggata 13080 cacgttcagg gcaatcatta ttatctaaag gtctgatcga acctgcgttt acaatggttc 13140 atgacaactc tgaagaatat aaacattggc cgaagtctga agtaacattc taccgcctga 13200 ctgaacttgg tcaagcttgt actgaataat aatttatttt attgaagaag gggaaggtat 13260 actttccctt aatttattgg gagagataaa catgatttca ttaaaagaaa tgtacgaacg 13320 cctcgaagaa ctgaaatcta aagaacgtct gtattcagaa gagaacgcag aaatgtcaga 13380 tcttatcgaa aaaattgcgt tgcgtgaaaa gtatcttcaa cgttatatca atcatccacc 13440 tcatatggtt gagcgcatgt ctacaattct cgaattggac aacagcggtg taacaagcaa 13500 agacctgatt gtcaaagagg ttcattccat ggtgtccctc ggtcagatct ttggccgcgc 13560 cgaccaggat gacatgatct ttttacttga aaaggctctg ataaaataat ggctatcaaa 13620 ccacgtatga tgtttgctca tatgcgatca gctgcagcat atggtgtaac cagttatgct 13680 cggcgtctgc aagtcggttg tgttatcgta aaccctgaaa ctgatcagcc tgtggctatc 13740 ggatggaacg gaacgcctcc tggcatgccg aatgtttgtg agatggaaca acacgggcaa 13800 attgttacaa acccgtgtgt cattcatgcg gaggaaaatg ctctaatgcg tatccccgaa 13860 aatgcagatg atttcacagg gttggttatg tttgtgacac atagcccatg ccctgattgc 13920 actcagaaga tcatcgacaa cggcaagatc gataaagtat attatcaaga gccatatcgt 13980 atcatggatg gaatcaaaag attgatgaac tccggaattg aagtttaccg gatggtgggc 14040 gatatggcaa tccttaaaca cgttttcgac gatcaaggcg aagtcggata cgaacaaatc 14100 ttatccaacc cagacaaagt aaggaattaa aatgcgttat gtagaccgca tgctcggcga 14160 ggattttgt tctggttatt ttaacgatta tcccaacatt tggattcagc ttgttatttc tgataccaac 14280 aattttaaat gtgttgacaa ctgaattcgc agtcaccaac aagcgcgtta ttgtcaaacg 14340 gggatttatt cgtcgtgatg ctgatgaact ccgtcttggt aaagtagaaa ccattaaggt 14400 ggaccagtct attacaggcc gtatcttgaa gttttcgacc atcagtgtta ttggtacggg 14460 cggtactcgc ctgttggcta caggttgtgc taaagggaac gaattccgtc aaaaaattta 14520 tgatcatctg ggtgactaaa tgattactgc aggatacacc gtcgatttgt attgtgagtg 14580 tgttgaatgc aaatcttgta attgggcttg ggaagaacat caccccagat gtgggatgaa 14640 gtcttatgct ggtgaatctt ggggagactg tgctagacaa gcccgtgctg atggatggat 14700 gatatgcagg gacaaacaaa cttgctttgc ccctggacat ccaaggaaat cagggtaata 14760 acaaaccatc atcttccgat tgcgttggtt gtttattagc agtttccttc ttcatttgct 14820 ctttcaacgc attaatcctt tgagcgcggc gtcgatcttc catttcgact tcgcgctttt 14880 tcttagaacg aagagcaaat tgttttttaa cttctgggtc ttcacctggc accaaatgtt 14940 cttctgtcca gataatgaat ttccaaccta cctttgcgca atgttcttta gttgctgtcc 15000 actttgcctg atttaccaac caagtgcgca ttgaattatt gaatgttgat tccttcatcg 15060 ttttagtttt gcgaggttct ttaatctggt ctttgggttt tatttcaata agagtaattt 15120 gtaattcatc ggaatcctgc cgacgagtcc aaaccttcaa atccatgaaa taacgatggg 15180 cgcggccatc aaccggagat atgtaaggga ttacagtttc ttctgaagac caatagacga 15240 tagcaggatt catatcacaa aatttaaagg cgacaagttc tagcgaagaa cgaaatacta 15300 ttttgttcac gtcgccttta tatttcttgg gatttacggg aacatacttc ccctgcaaat 15360 acatagccat attctagtcc taaatagtgt catcactcta ttctaattaa agggcttcag 15420 accatggcga atttcaagtc gaccatcgat aagatcaaag ttctgaacac aaaaggcttg 15480 gccaagtctc agaagcaatt ggtctatcca ttagacataa cagggggtaa aaccctcggc 15540 cattatgttc tattcaacat caaccgaata tctggttctt catatggaga caccacaacc 15600 caaaccgtcg aaaatccgat acaaaatcca ttgggtaaga ctcctgtggt ttacggctct 15660 aaatcgggtt ctattagcaa atatgcttgg gcgcgtcatg tccgctctaa cgagtcaatt 15720 gtgttgtgta tgcccgaatc cattacaacc aactatggcg ttggctggaa cggctccgag 15780 ttgggattag caggtatggg tgcccaattc ttatcacgcg ccgcccaaga tatgagtcaa 15840 ttcaaacttg gggatgcttt gaatgttggg aaagaaatgg ggagatttgc ggcaacaaag 15900 gccattcaat ctgcttcgga agcaattcct ttcttgccga caattaatgc tcatgataca 15960 ttagaattgt ttacaggtac gatgaccaac ccgtatgtgg aaatgatttt ccaaggggtg 16020 cgcaaccgag aaatcccgtt cacattcaaa ttcactccaa gatcgcaaaa agaggcgaaa 16080 atggtgcggg agattatccg tttattcaaa atgcacatgt atccagaata caaatacaac 16140 aagaattcca gcgcattcta tcttcatcca tccacgtttg atatcacgtt catggtccag 16200 ggagaacgca acaaatggtt gcatcggata tcgacttgcg tcctatcaaa tatgtttgtc 16260 aacgagacgc ctgactcttc atatgctgta cacaaagatg acagcatcgt gtcgacacaa 16320 atcgacatga cgtttataga actagaaccg ttgcacaaag gccgctttga taccgaaggc 16380 gacagcttct aaggagaaga tgccatgaaa tattttgaga aatttccact cgtatggcat 16440 caactaattg gtgtcaaaga ggatgaccaa gtcctgttgc agaacttaac acgacgggtt 16500 atggttgtta agaaaattag ggacatagaa gggcttctcc tgccgtatac tgtttttgat 16560 ggggaaaccc caaggtcttt tgccgaacgc gtctacggtt ccttcgagct gttttggatc 16620 ccatgtctta tcaatggtat catggacatc gtagaggact ggccgaaacc ggagcgccgt 16680 atcattgaag aactgactgc tcgatacggc cttgacggaa tgtgggatgt gaaatactat 16740 gttgacgaat tcggtcatga aacagatcct agagcaatac gtttagcata tggccttggt 16800 tctatggatg attccacgat tatcaccaac tatggtctga caggtattac atatcatgat 16860 gatgctataa acaaaaacga agccaaacgg aatattcagg ttctagaccc agattatgtt 16920 tcttcctttg ttaatcagct ggaacaggag ctgaccaaat gatcgaaaat aaagaatccc 16980 aggacggaat tttaactccg tccacaacat ttgatttgaa atatatggcg atattaccac 17040 acacgcctga aggcggtact cccaagcctt atgacctttc atcgttgttt caagaattca 17100 acgtatatca ggatcttggt ctggaaggga atgcttcacc gtcgctgaca gctaatattc 17160 tgatcaaaga aggctgggat atattggata caatgccaat cctcggaggt gaggaagtag 17220 tggtatcgtt caaatcgcct gcagcttctg attacactac gctttcattg cgagtcagtc 17280 gggtagggag agttgctgat gaatcgaact cttcttcgaa aaaggcattc tggttacact 17340 tggtaacaac agacgcgtat cgagatagca tgttgcgtaa atctcttgga ttaagcggtt 17400 cttattctga gatggcagct aagatctttg agcaactgaa ttcacgcacc aaatttgaag 17460 acatagatcc ttcatatggg atacaagaaa ggttcgctac ccctctttgg cctgtactcc 17520 gctccataga ttatatggcc agccgtgcat atgacgaatt attcatgcca ttcgttttct 17580 atgaagactt tacgggttat cacttcaaaa gcatgacgac gttgttcaac cagggcaacc 17640 agtctatgac tgctgaagag aagcaagagg cttctattga aaagaaattc ttccgagacc 17700 ctcaagacgc gccgttgatg caggataaca atttcaactc agaacgtttc atgcggacta 17760 tcatcaaggc tgaaaagaaa ctggcgcgtg atcagtacat ggcgaattat cgggatatct 17820 tggcagtgaa cgagcgcgtg tatgacttta gtacaaaatc cacgacagcg acccaacgca 17880 tttattcaga atggtttgac agcacggctc accttgatcc gttcccgtta ttctcggatc 17940 aatttgatcg tgaaaatgtt cgttatatcg aggcacaacc agatggagct gaacaaatag 18000 attatgctcg ccgcgtaata gaattcagtc tagcatctac ggttatgcgt ttgctcgtgg 18060 tcggcgataa ccgcctgaac gttggtcagg tttattatat tgaagacttg tctaaccgcc 18120 ctaaatctaa tgaaaacatt gccgagttaa gtaagttatc atcaggccac tatattgtca 18180 caaagatacg ccataagatt tcacgcctga caaatgatta tcaatgcgtc gccgagattg 18240 ccaaagacag tatgatccag aaggtattac cacctcagac tggacaaact gtggcttcta 18300 acccaacccc gacgccaaca gagaaaggac aagcccagaa ggtctgagag gtgacaaatg 18360 gcagataaca atcaaccgac accagggcag caggacatcg tcaaggtctt ggataaaatc 18420 aaaaaggaaa tgatggagcg caagcaattg cgcgcccaat ccgagacgaa taagcagctc 18480 gctgatgtca acaaacaact gcaatctctg aagacaagac aggcgtctaa tcaggagcag 18540 aaagtccctc caatcaaatt cccatcggtg aatgacatcg ttggtgggtt cgttcgcgtt 18600 agtcctattt tcacaaggga ttacagcact tggatgaaag acactgtcag cctttccaag 18660 gacggaaatg aagaactgat gcgaatcgca accaaaatag aaaaatttgg cgaagcggcg 18720 aatggccctg ttgatgatat gtctgttgaa tatcttgaca tgatatcgga tcaattagga 18780 gcagcgaatg aagatagtct agaacgtctt gatggattac aggacaaact agcactggtg 18840 ggagggaaga ttgtaaacct gaccgacata atgcttcaga ctcataagga cacgctggac 18900 ttcaataaag atgccaacaa cgaaaccgtt actcgtcttg acagcattga tgataaattg 18960 gggtatatga atgaagacct caatgacaca ttaacgcgta tctatgagag tgatcaaaaa 19020 tatcgagaag aagagaaatt ccggcgcggc gaagaaggta aagagaacaa gaacaatccc 19080 gaagcaggtt ctattccacc ttctgaacca aaacaggacg ggcaatcttc cggtatgggc 19140 gcggcgctgg gtgcacttct cggcttggga gcattgaaac tcctgatgtc tccactaaaa 19200 ctcattggag gattcatcaa gttattcatg ggattcggga tgggcatcgg tggtctattg 19260 aagcctttga aagcagcgac caaaatgctt cgagtcggac ctttggctct gataacatct 19320 gtatttgaat tcggtaaagg tttcttcaat gctaaagaaa tccttggcaa agcccaagtt 19380 tcaatagtag acagggttca ggcgggcata acagaacttg ttggcagttt cggagatctg 19440 gctgattggg tggctgaaat atttggttgg gataacgcag gatttggaaa ggcgttccgt 19500 gaacaagtat tgaagatgac cgaagcacca gtgcgctggc tcaattctat cgttgattgg 19560 gtatccaacg atctgtttgc tgggatcggt aaagggacag cgctgactga aatccctggt 19620 aaacttgcag acaacttaca aggccaattg ataaaattgg ttgattgggt aacgggcgga 19680 atatcaggat tgattgatga tggcatggcg gctgcaaata aagtcgttga agacatgaag 19740 aaaggatttg ctgaaaatgt gaagaaacct ttcttcaaca tgttgaatgc tatcaccaat 19800 gcgatgtttg atatcgtgga taagtttgtc agcattatcc ccgatgcgtt gggtggtgaa 19860 gcagccagga ataagatggc ggaagcaaga cagtctatgc tgataagcca agacgataag 19920 gctcctgaga atgcctctgt accaccgaac agtcaatcgc cagcacaacc taatgcagat 19980 atcagcacgt taactccaat gccttctggg gtttcttcgg atgctgtgaa cgtaacagat 20040 cgcacttctc aattgaaaga tgcatatgct gggatcgggg gaggtactct gggtggggca 20100 tatccggttc aggggagagc ggctaacaac attgaggaag ttaaatccgc ctatgctaac 20160 ccgccagcca gtgttgtggt tccagtacaa caaaatgtgg acaactcgaa gaaagtcagt 20220 acgacgaaca acttcaacag ttcacaactg gagccgtcca accgtactga cgcaggtcgt 20280 attctttggg attggtaatc aaattccgtg ggcaaggatt agctcacgga gttttccttt 20340 tgtgtattct gtgttttcat caggaacaac tgaattggtt ttctttaata aaaaggactc 20400 ggagttccaa tagatgtcat ccttgagtat tgtatcatat aaatggatga accccactac 20460 tttattcaat ccaactagaa accaaattgg atagcgttta acaataatat ctgtcagtaa 20520 aggtggatgc ccattaccat ttcctttgat atattggata aaattcacgc ctctttcttt 20580 tatctcaggg atcatatatc tctcaaaatg ttcaagaaaa ttatatgaga agttgtcata 20640 caggcggcga tattcattat aattttcttg ggcctgtctt gtaagtaatg ttgtcaccca 20700 cgtctttggt gatttaacaa agttggcaat aatataattt tccaccactt caccttggga 20760 agattcgaac cgacgagcaa gtttagcaaa ttgtttggcc acgccctgtt tagaatagaa 20820 cgtttcaaac ttgtaattgt tcatcggccc atacaggcca taatcaaagt cttttgaggt 20880 gaaatgcaat ttgatcgcca tatagatgca ataaacgttg aatgcccttt catattgcat 20940 tttctcccac tcagttatca tggcgtttct ccctgctttt ctgtttctgt aatctgcggc 21000 gttcagaaca gaactgattg aactccgtca ccaatccttt ctcctttata aagagaatgg 21060 cgtttcgaaa agcaattcca atcttggcat atgacggcgg attcttacca accacgtgat 21120 ctctcctctg tgcgaacgaa acgttgaaac tcttctgttt ttccttggcg atgaataaac 21180 accaacgcca aaataaaacg acggaatgat tttgggataa gacgatagcc gttggtccaa 21240 ttataaacga catcagaaca attcatcatc ttcatcatct gtaattcaga aactcccaat 21300 tccctcataa tgtttatgag attaagagaa tcattgtctt tccttggttt cttatcaata 21360 agtttcataa taacacctgg taatgatttc ttggaattat actgctactg tctttattga 21420 atggggttcc gaagaacccc aattttcatg ccgcttccaa caacaccaaa atattttcga 21480 tatatgcttt ctggatagca tagacttcag ccagtgtatt agcgactttc ttgtctgtgc 21540 gtacttcaac gagacgtgga aggaatagag acttcatggc gtcatcggtt ttatcctgta 21600 cgccattaga gagcacggcg gcaatcttac caatgaagtc ctcttggttt tcccacattc 21660 gtagtctcaa ctcatccgag atccccgata cgccaacaac taagaggcca tcagaggtct 21720 tgcagaggag agatccaaat gtcttggcgt gcttcccttt cttatcggcc tcgttgaagc 21780 caacgatttc aaggtcacat tctacttcca tttttagctt taacccttca gatgatgttc 21840 catcttccca aggcatatct gcggccttac aaatcgtgcc ttcttcccga cgagccaaag 21900 catctttgaa gtgttcgaca gcttcttcaa atgaatgaac gacacgggtc tcctgaacct 21960 gaaccaggcc gtcatcccct tcgaacaact gttgtatgat atcaaaacgg cgctcatatg 22020 gggtgtccac acgctgagca ttgaaccaat tatcatacgg cacaacgtcc catacccgat 22080 agatcacctt gtaacgatct tccaggggtt cacccgtttg gataacactg ttgagcttac 22140 cattgccgat agcccgaggc aacactgtat tcgttttcag atcaatgacg agcagttcac 22200 catggaagac gctttcacca atccccgcat catagatcag gtctttgaaa accaatgaca 22260 ggttatcaac ggaaccaccc gcaataagag aaccggaacg agaacgaatc tctgggtctc 22320 ttccataacg acagatgatg ttggcgaaca tgccatctga cttcagctgg ctgaagacgc 22380 cgcgcttgaa gtccatcttc ttcagcaagt caatcgtcat gttatcataa cggtgatatg 22440 gaaggatatt aatcagacgc cctgtaccac ctgctgcgtt gaatgctgcg tttatacctt 22500 tctcggcaat tcccgctttg atgtctctgt cgagtataat ttgtatcagg gtatggtaat 22560 ccggatggat gttggtcgcg gccttcgcaa gttcttgatc tgccttcatc ccaccgatct 22620 tgcgttcggc catcatatca agaacgtcat aaacctgatc ccagctaccg acaacgccgc 22680 gcgagagcat gcgagggaat gcgtttagat tgaattgagt gcggtaataa gaacgcatcg 22740 gatcgtagac gtattgaagg aaatcaacca attctgggtt gtttctgaac gcctcggtca 22800 gcacagcttt cttggcgttg gtgcctttgg tatcgcgaag attttgaatt atttctaaaa 22860 gaggaagcat catgtgtctc cagggttatt cgtcatgcta ttataaccct agagacttca 22920 atagatttat ttgctgcgtc tttttctggc cttgtcaaca atctgaagaa catccactcc 22980 atatttgcgc attcttctat tattgatcca ttcggcccaa accggttgaa aaagaataat 23040 caagatcccg aaaaataata ttgcagacca aatataaaat gaaatatctt tcatatgtct 23100 tccttccaaa caaatccata cttggaaaga taatctggtt tcgttccatt acgagttcga 23160 gcacgatcca cgatagattc tacagtttct accttgtgaa tagggacatt tccattgttc 23220 atatactctt taaacaacct gtgaagatat atcaaaaatt gtttatcgta agtgtcgttg 23280 taattccaaa accatacagc agcctgatat ccatctttac atgctatttt caaataaaaa 23340 caatttgatt ttgatacaca cgattctatg aacggccaac ccaaacctcc catgaaatat 23400 tgaaaatatt cttcaggagt agtgtctggg tctttgtggt ctaagttgaa atcatctatg 23460 ctagtaacca aacttttgga cacacgacta ctcagaataa gttttatgtc tttaacattt 23520 ttcgtggtat tttctggttg taaatctgag gagacggcct caacaacccg ttttcccaaa 23580 gattttttga ttcccataac gagaatacaga accccaacca tactaagaac agcaatcaaa 23640 atatctgttg agtcaataat gaccataaat cccccaaatg aaggggcata tgccccttct 23700 atattatttt gataaacttg ccagataatt gtccgcttct gttgctgaag ggctattggt 23760 agaataattg gaatcagcga tttcagcttc ccgcaggata gcatcaacat ctacattaat 23820 cattccagcc gcgtaatcga tgtcttccgg taaagttaac ccaagatcat ttgattcttt 23880 ctgaattcgg accaattcga gattagactt aacagcgtcc agtttgtcac ctaattcaac 23940 aattgccgaa ttcaatttca cgctgccaga ttcgatctct ttgactttat ccagcagagc 24000 ttcaccaata cgacgacggt ggagtatgat caaggcttca gcgcgggtag gagttactcc 24060 gcgagcgatc gcatctttca aaatggtttc tcgcttgacg gcttcagcca gattttcatc 24120 agcggtcttc ttcatcttaa cgccatggtg gacattggtt acacgggctt cttctaaacg 24180 ccggatttca tcagatagtt tccgtgcagc cagattcaaa cgcttctcag tatctgtgag 24240 tttatccaaa cctgcagtta aattggcctc gacagtgctg aacaggcggt ttaaaaaggt 24300 tttcagtgac attaatatat tcctcaatta tttcttaggt ggtgtgacag aggtgaagga 24360 ctccttccaa ctcttgaatt tttcaatcag ggattctttc cccatctcgc cgttggaaac 24420 atcatggata taagcaaatg cgtcataccc atatcctggt aaagcagaac agattcgaag 24480 gtgaaccaaa gattctccca cagaaaccaa ataatgatcg cgacgatcat tcagagcata 24540 atgattgtcg tgaaacttgt cgatgatggt gcagttttta ggctcaacat caatcgctaa 24600 tccattggcc tcagagccgc cgcgcccaag cgtacaacct gggaataatg tttctacgag 24660 tgtggacatt gtttaattcc ttctgtttaa ttcccatgta ttatatgggt aaacgtttat 24720 tgaattattt gttgtgatag ccaagagcct tgcggacttt ttcacggtca tctgtatcga 24780 cctgaattgc tttacgatta atccgacgcc tgtggtgtcg ggtgagcgct ttatacacgg 24840 ccttggcctc atggtatggc agacaatcgt aacaaaaacc gatatcgact ctataccctg 24900 cgttgctatt gactgtatat gcacataccc ttacgccgtt atagatgaca gcatctatac 24960 cgacaaagcg ttcaccattc cattcaacgt catcagcgtc gatagcatca ataagacaac 25020 gaatttcgac gcttaggggt ttacccaaca accagttaaa atatttgcgc atgtcattta 25080 ctcatcagtg aaagaagatt gactttatct gaacgtgcgt ttggtgagta atgcacgtcc 25140 tgagagtgcc tcttacagca cggacaatcc ttggtggcga ttacacaggg agctttatcc 25200 acggcgtatc cggcttcttc ggcttccttc acggtgttaa atggcaagta tgcacttgtg 25260 ccttgccctc cgcatgaaca ttccattaga aatcctcctt ggtaatgaag agcaaatcag 25320 atttcagatt ttggcgcttg acacggcgga catgtcgatg ctccttttta ataccgtctg 25380 aacgttttga tttagagcgg cgatttttgt atgtgtccgc tgggtacttg tcatggcctg 25440 gacaacaaga tccagggtag taaacatcca agatttcccg tttcattaac gtttcctctt 25500 aaatgggatg atcagggcta tgattaacag catagctgtg atcactccgc atgcgataag 25560 accgaatgca aatgctttca aaacaaattg taaaagaatc ataatttcct cagttttgcc 25620 cttgtgatct gagtttgttt aatacctttg aattcggtca attctttgac gcgaccacga 25680 atgatcatat cgccttctaa aaactcggtt tccatatagg aagtcttcca tgtaatggta 25740 ttgccttcct tggttttgaa agtatacaga tacgtgtcac cataatcaga cgaatacagg 25800 aaaatccttg cttcaaattt gacttgcact tctaacattt caccgacttc accaacccaa 25860 tttgatacag tgcgcgtttg gcgcggggtg tggatataat cataatactt tgctgctccc 25920 caacgaactg tcgtggagtc cttaacgagg tgatatcccg gttcacacat acgtttcagc 25980 cggacgttga aatcgttatt ttcagacaac gcggcgatga aaagcatcat atggtacatt 26040 tctgattgag catcttcacg ggctttaaca gccttgttat agaatatctc aatgtcagaa 26100 cctttctccg gacgagtacc gctagagata tgaccaagaa ctcgaccaaa atcatcactt 26160 ttaatgctca ggccggacag caaaacctga aagcatttac acaaatatcc ttctgtgtca 26220 acataatctg gttcattaac ccgataaatt ccttctgggt catcttcatc gggggtaaac 26280 atttcgtgaa tagacatgta ataagacata accgcatcaa gggatttctg atgcgggaca 26340 taatgatgca tgcagctgct acccacgagc atctgtgcgc cagattgttc gttacgaaca 26400 acatatgtgt tatgacgacg cacagatttg ttgcaatgct cgcaccaaga tacgttttca 26460 gcttcgaatc tttgaacgaa atttgggtgg atgtcatctg acagtttatt cagaatgact 26520 tttggatact ggtggttgaa ttgtccaatg atactccacc caccataaga aacggggcgg 26580 tctatgcctt caccagttag agtacaatct tgccaccaac gataaaattt ttcgccagtg 26640 atagaatcgc gatgttgtgt tttgtatggt tcactgaact caacaagagg aaactcgagt 26700 ttcaggcggt ttgccgttct ttcaagtttg gcaagacgtt ccttgacacg accaatgtta 26760 tcaattggga tgctgaaggt cttggctttc atttttgcct ctcatgatgt agtgaaactt 26820 ttcaatgtag gttaaatgat agccgcaagt tttattgaag taaagtttta ttgaattaaa 26880 gcccaacaaa tgttgggctt ttaccgatat tattcagcag tgcgatcagg tgctgcgtta 26940 ggatacagtg actcataaag atcctggtat ttggcgctgg tctcgatggt cttggtataa 27000 gttccaccag cgcgatcggt aacgactttg cgcagatcaa cggctttgat gcctgtttct 27060 tttgccaatt cagccagggc ttcggtaaca aaggtctgtt cagacttgat acggatctgg 27120 gcggcacgac aattttctaa agtctgcatc atcttttgg gcagttttgg atcagaaggg 27180 agttgataaa aaccaatttg ttcaactgac ataatatatc ctcattaatg acgagaaccg 27240 agtggaccga tactggttcc caaacggcgc aggaagaaat aaacgatact gtgaaaacca 27300 aacttaggaa taatatcaac gccttcaaca ttgtaatatt cctgagtgtt ggtctgtact 27360 ggcaatggaa aagacggaag atcaagctga accaattcac ctggttcgca atgtatcttg 27420 acattcttac cccaatgccg acgattctta taaaattcta gagtctgctc tgtagtgagt 27480 ttgagactgg tttctccaga ctggcacacc tgttgtgccg cccgaatcag gtcagctata 27540 aatgcaacat ccgacatgat gtgctcctgg gttaatattc agatcataga gattataccc 27600 tatgatcacc attattgaag ttaaccgaaa ttccaattgt tcacggtctc ggctttcttg 27660 acatcattta cgtcgcctgt tttgtttaag tcatgtttga tatgaacatt ctcaacataa 27720 cgggcttctt cttctgtcag gtctcgcttg acttcattcc aatccaagtc aaacaatatc 27780 tgtttatctt gatccatacc gaacaagaac gatttgagtt tctgtttatt ggcataacgg 27840 tttttcaaga tagacgctcg ggctttctta acagccgcca gttcatcagg ggcatagaac 27900 gccatgatga agtctgcaac cttcggaata ccgatagcat ctgccaggtc gctaatatca 27960 ccatcagtcg ccgattgttt ttcacggtta aattgcatac ccgtccatac agggcaatca 28020 aattcaaatc caagcgcacg gaattcacgc gccaccgaag tataatacac gttggtgttc 28080 tgcattaaat gagcaggaag acgagaagac gctgattcac ccaagtagtc tataataatg 28140 acgtccggcg taattcccgt ggatgtcgcg taatcaagaa tatcgcggcg atacagtcct 28200 gtatgcccag cgcctgaagg atattccttg ataacaatat cacccttcat ggaaccgtct 28260 tgacgagttc gcaacttttg tatcgtagcg acatattcat gtcgtgagag cttctctaag 28320 gactcgaagt ccctgcgcat catacgggca tcaaggcggt gacgccagac gttctcagcc 28380 acttctaggg tgaatacgaa tacgttcaac ccttgctcgg agtaaccagc agccaaatca 28440 atcagagttg ttgtcttacc cgcattaatt gcacccgtca cgatgttcag cgttttctta 28500 ccaacaccac cacgagtcgc tttgttgaat atctctacag cgaaaggaat cttcgcttca 28560 ttagagttca tgtggtcgta ttgttgttca gccatttccc aatagatatg gccaagataa 28620 gaatcaaaac ttatcgccaa cgcctcttgt aggagagttg gaatcgtgtt catctcatct 28680 ttacgtttct catcaccata gatgttgacg gcgtgtttga tcgcattatg aacagctttc 28740 tgccgcgccc aactttctgt ttcttttaca agccattcct gatggaatgt gttgtcattg 28800 atattctcaa gagcagaaat agcttgttca aatacgtgtt cgttgagcga agtcttttcc 28860 agcataatag acaacgcttc aaccgaagga cgagcattat attcgcaagt gtaatggtca 28920 atgagaccga atataatttt ctcgccttcg ttatcgaaat aatcggcttt caaatacggc 28980 tggatctttc tttgatattc ttcgttatag attaattggg aaagcacgac agattcgagt 29040 aacattggca actaccccac caaaattttg ttgtaatcct gagcattttg ctgtatcaga 29100 tcaactaaga tatccccaga caccacagtg aacaagtcat tttctttcaa attaacaaat 29160 aacaaacgcc atggtttctt caatatatct gttgtaaagg ataaccgagg ctctccatta 29220 cctgatagga atttcgatta ttgctaactg atcagaacca gggtcgatga ttttgtaatt aacggggagt 29340 ctcctccccc tgcaatatta ctcggttgtt ttgatgacat tatcgaggcg ctccagcata 29400 tctgcaggca taaccgaact ctgagagata ccgaacatgt tgttcacatc gtcaacaaag 29460 tctgggtttt ccagcagcgg ataccagaag tcatctccca gctctgcctt acgatatttc 29520 ttttcttttt ctggatcaaa cccgcctttg gcagtgcgtt gataccaaga accactcacc 29580 aaatccacat accccagcat gcgcgcaatt tctaacatac cggaccaacg gtcaataccg 29640 ccttcataca acacagtgac agggaacttg gctttttcac ggacaaagcg gcctttcata 29700 atgttgactg taaactgcca tcccaaaagg tctttgtctt cttttacttg agcacgcgtg 29760 atgaaccaca attggttaga agacaggaac ccctgtttac cgcctttgat gttcggctcg 29820 gcgtattggt tcccgatttc atcatagtac gagttgatcc ataccaaaac gaatttcttt 29880 tcagtgacca acggggtgat aacacgccaa aaactattga gagcgcgagc gcgggtcata 29940 tcttgtgtgt ctttgcccgc tatggcatca tcaacttctt tagtagacgg caactggctg 30000 attgagtcaa tgaatacgat gatcttgtca cctttctgtg catcgttcag aagctgtgtc 30060 agcttgatct tcgtcttttc aacgttttca attggcagat acaagacacg gtccatgtca 30120 atacccatag atgtccagta gttttcattc gcaccgcctt ctgaatccgc gaagatacaa 30180 attgcatcag gaaacttatc catgtaagcc ttaacatcca ccagcccaaa catggttttg 30240 aatgtacgag aatcccccac caactgtttg atgcctgata tcagaccacc atcaatacga 30300 ccggaccagg ccaaattcag aataggaata cccgtactgc aaataatgtc aggcttcagc 30360 gcatcggtct ttgacagcac ttcggcattc gggtccagtt tctttgctgt cttgagcatg 30420 cgagccatca atgaatcggc catttcgttt cctcttgctt gttgatcgta attaataaat 30480 cggtgcccaa tactttcttg gacaatatat tgattgcttc gtgaatcgcc attattgacg 30540 ggagtttttc atcgttaatt tcggaacccc cgcgttctgt taaatacata ttacgcagac 30600 gattgtgctg tgccctgttg acacaagaaa cattcaatgc gatattcagg atatacatca 30660 tttgttcagt tgtaacatcc tttggaatag catgaacata atatatcgca tcttcaaaat 30720 agatatgctg taatgactct ggaatttctt ccccgccaaa agcaaaatct tcaatgcgtt 30780 taaaaagtgt ttccggctct ttggttgtaa tatgttgtgt tacagtagcc gcaccatctg 30840 gctctttctt gaaattggtc gcaataacga catgaccgcc tggtttaata aactcagcga 30900 agttctctgc catgtacggg gcatgttccg cataatatga tacgacgact gtaaacatta 30960 gaactccaga gtcagagggg tttcggcaga cttgtcatag ttcgcaccgc cagcagcacg 31020 tagacgattg cgatcgttct tgcgtttgtg tgccagcata taggtttcgg tgtccagatc 31080 caaataacca caagcctttg ataaaaaccg cacaaaacgg ataacatctg gttgttccat 31140 aaatgacgta aaacattctg tgaccgattc cagattggcc gatttgtcta tcactcgtcc 31200 gtccttgaag aaaaggtcaa tctgcatttc aactgggaaa gcagaaccaa atccagataa 31260 aatggaagac aacataaaat gtaccacgtc caccaattcg tagacagctg cttctcggtc 31320 atattgtatc ccaccgccat agattttcca gtcctgggtt gtttcgtcaa gaaactctgc 31380 ccactcacga tagatggagt tcaccaccgc cacatgagtc caatgtttac gccactcttc 31440 cccaaaatag gccacattgg tggccttttg aagttcgagc agacttttga tatgctctgc 31500 tgtgatcatt tccgttccct ataaaatttg acgaatggtt gccaaccttc aaatgggtta 31560 acaaattcat aatcaacttt catctcatca atgaaagcct ctatgtcgtc ctctatgata 31620 ccgccgcgat ctgcctttga aatgcgggtg atgggacatt tagtgctcag cgcccattca 31680 tattcttgag gcgtccgtag atcactcaca atataatgaa tgttaggatt ctgttcaact 31740 aatgggagtt ggtaacgctt aaagaaagac aaaaacagat ccggttggac ataacgaagc 31800 cccgtatcgc tgccgagatg aagccagatc tgtcgtggag ttaagccctt ggggttatca 31860 aggtgcacgt aaggaacgtc cttcacggca tcctctacct cctcaggcag ccacgggtag 31920 atgtagttgg caacacggcg cagctcatcc gagaaagaca ggcgttgaat gtccttgtct 31980 ccctgtagat ggtggtagct gatcagggac tccaaacaga agtccttgcc ggagcgctta 32040 cgccccgtaa agaattcaag gtttggatac atcataacgc accttccagg aactttggat 32100 caacgatctt gcggtcaacc ggagagtgag tgagtgcaat gttcagacca tgatcctgaa 32160 tcaggttcat gttgatcagc ttatcgttca gcttgcagta caggcagtaa gccatctgca 32220 cgatcaggcc acgatcagcg tcgtattcct tcaggtgagc aacgacagtc tcccacgggc 32280 tgccaatatc gcagtgatga agcacaccag tgaacagatt gcggatatgg ttctggttgg 32340 tcacgttcgt gaagtggatc atcgagttga tgaacccagc ttctactttg gtgtccttcg 32400 tgatcttacc cagctgcttc tggctgactt cattgttgta gtaatgaaga ttgttagaga 32460 acagcttgta ctggccgacg tctacatcca gcacctgcgc gatcacttcc tgaaggatag 32520 agaactcaat gaagttgatt gaactcatac cccacaggac atcttgtgag cggttgatga 32580 ccgtcaggtt cagacgacct tcaacgacag caaataacag agccaggtta cacaccatgt 32640 ctttggtctt cgcttcgttt gagccgttgt gcttggccag accaacatca gagtccagag 32700 acggatcata gatggtgaga tacgcctgac gggtgttgat gtttttgcgg agacggttga 32760 tgacgctctg taactgacca tgggcgtaca ggcgcggccc ataagcggct cgccatgtta 32820 ggccatcgtc ggagaagttg gcagcgcggg gcaggacacg tgacaggaac ttcaggtcat 32880 tgcgcccagc cagcacccag aaagtctcac cgatagctgc gatggccgat gagttgcgac 32940 cttcaacgga taaccagcgg tcacggatat tactgacggt gatagtcaca ccatcaagaa 33000 agcgggtgcc gtcagtgttg atctccgcgt tgccaggatc agattcaatc ccgtattcac 33060 ggatagccaa gacagcctgt tttagcatgt cgttgttatt gatagcttta atttccatta 33120 gtcaatgctc ccaaagtcac ggaggaggaa cgccattaca gcttggtcta cagttagacc 33180 gtgagacttc atcatacccg cacacacggt agggaacaac tctttatgcc gcccccgatg 33240 gttgtgaacg cgctcccact tctcgaccac cagactttca ttgaagtctg cgccaccgtt 33300 acgcgatttg acacgggcaa tacaggtttc aagaggggta tccataaaga ggacgaccaa 33360 ttcacgtggt gggcgtgtca ggcggggaat ccaagaactc aataatgtag acggaatgat 33420 gccttcgaaa atcacatcat atttcaggta ttctggttgg tcagcaatag acaacgcgaa 33480 caacatctgc tcagtgtccg tcagagaatc aacccctttg gacttagact tgtcatattt 33540 accgacacag acaatattgt aagatggaca aaccgtgagc atgatcttac tgttatgggt 33600 tacgacatac gcctgaggat cattctccgc caaataagaa ggcacagtag acttaccact 33660 accattggag cctttaatgt aatacaactc tcctcgtgcc gaatattccc cttctacagc 33720 aggtggtttg acaaacaaat gcacagggcg cttcaacagc cctttgagcg aataagacat 33780 gacatgctcc aataaacaaa aggagctgct attatagcag ccccttcatc tattgaatgc 33840 ttctgaatta aattacgcag cagctttcgc ttcggccaac gcctgtggca accattcatt 33900 gatcgctttc accagagatt cggcatcagt ttctttgatt ttctggcgtt tggtgaatga 33960 tttaccattc acatacagac tgaaccccca gccgccggaa acgattggcg ccagatcaac 34020 ataagtattg gtgcgggcgt gtggattggc ttcatctgcc agttcggtaa cagggaactg 34080 gaaccagcgc atatccggat tcacatagct caaataaacc ccaggcacaa cccctgattc 34140 aaccgcagcc aggataggac cataattgga tgcgcgagcc gcttcaacca tttcttcacg 34200 gt; cttggccaga accgccttcg cgttcgctaa agcctgatca tccttcggat tttcaacgtc 34320 ggcgattgct tcagcaacgg ttgtgcccag catacgacgg cgaacttctt cagcacgggc 34380 ttgcgcttct tcgtcaagaa cttcttcgcc ttcaactacc agggaaatgg aaccgtcttt 34440 gttgacttca agagaaccgt cttcgacggt ctgggaattt tgatcaccga caggttgccc 34500 aaccgtttct tcggcgtcaa tcaccggatt tgattcaccg tcgccctgtt taacccccgc 34560 atcttcggtc ggtttaactt tttcggcttc agcgcggtca agagcttcga gagtttcttc 34620 tttctcttcc tggctcagac cttcaatgag ttcaaagcca ttggctgact ggaggacgcc 34680 ttccatcata cggcgtaacg tgacgttgcc gatgataagg tctgcacctt tgatttctgc 34740 ttgaagatca gcagcggttt taccatcaat ttcaaatttc aggccggact cgatatgaag 34800 aatataggac ataataaaaa cccttttgtg tagtaacctt ctttggcagt ttaatgttca 34860 actgtgcgtc tggaacatta atatactgcc tttttagaag atgtaaacca ctttttattg 34920 aaaagttggt taacacttct gtgttagaca acggaacgct gtatcagcgc ggactggcgt 34980 gaatattaac tttgtatatc aatattgaaa actgtttcag gtggccacat ggcagacaac 35040 tcgatctgtg tgaacttcgg ttgaacatac tgatctaaca cttcatccca gagagcatgt 35100 tctatgttgg caatcaacaa ttcgtcgtcc actatttcga cggaatgaac cactatccgg 35160 tggttataag tcaaagcatc gctcacatga tcattttctg ctctcaggtg ctgcattatg 35220 aaatattcga ttacagattc cagtaccgtg ttcaggcgaa catatttctt catacagccc 35280 cctgcttgtg ctacagatag aaattaggga tttcgccgga ttcacaacca aacccgttaa 35340 aattctgctc aacatgtaag cgaattttgt tcaccactac ctgacgatgc tcttcttcca 35400 tacaacgttc aatcaaagaa tacgctgtat atgacagact gttgaacaat ctggaaataa 35460 caaggcaatt ctcttcattg taaacgactt cagtatggat tgcgaaagcg tggtcttcgt 35520 cggtaagaat tttacagcct ttgaccacaa atggtttttc aaagaaatca cgagctgaat 35580 cagtgccaga ttccggcatt aaacggaaat cgccttcttc gccgaaaact gctttcagat 35640 tttctttact gaattccgct tccatctgta tacgtttgtc ggcaagatat ttcgccgcaa 35700 agtagaattt acccactgca tcattagcag cgcggcggtt cgtagcggct tgggtataac 35760 cagaaacgaa gtcttcaatg aattccaatg cttctggttt gccaaaacga atttcgtcgc 35820 ccagatccaa gctggcttcg gaatcaagtt caatacccat aaccttaaga agatccgttt 35880 cattcagcct gtgcggatta aacaattgtt ccttggaata tcccaactgg ctaccgagtt 35940 catatccggt tttaccaccc gaatctttat gggtgcgatc atagcgaacg caattagaac 36000 tgaattcaat accaaaaata cgatgtagct gtgacatatc ataacctcat gtttatagaa 36060 agccgttcgc gaattatcac gtagaacggc ttttagaact aaccattttt gtgtttacga 36120 cgtgcgtcct tccaaacaga catctgactc tgtttctgga atcgagcagt acgcataaac 36180 aaaacgacct cccaatattg cggttcaatt tcataaagtt gtgaacgaaa ttgatcagcg 36240 cggtacagtt tcacacaatg gttgtacaga gggtgattgg cgaaccgttt cagggcatcc 36300 caggtaagtc tcaaacgtgt tttagaacga tatgcccgtt catttctcaa tttaatgaga 36360 tcttcaaata ccaacaatct gagtttaggc ggtaaataat ggaggtttag gccataaaga 36420 taggttacac cacgttcacc gaatttcacc ccgtccccct tcacaaaatt gaagaagaac 36480 accagaggat acatatccca atacgggagt tcatctttag tcagcgcatc atatttgaaa 36540 taatacatgc gaccaacaat ataacgcaca ccctgaacag gacgtttatt ttcagcgaat 36600 gctttcatca tgtgattcgg agataagtta gcatctttcg atacgcgctc cataaaccac 36660 acatgagaac gacggatatt acgcttcgct tccggcccaa aatgttgacg atatttgcgg 36720 atgtaacgct tgaccagttc tggggcgtcc atctcggcgg gaagcaacaa cgggtcttct 36780 tcacccatag cgttcttagc catttgtcaa ctccttataa atatcaacag atatattatt 36840 taaatggagt cctcatcgtg gaagactatc gcaattttct aacgcaactg cttcaacggg 36900 gtatttcccg caagaacaga tttcgtgtta caattccgtt gccgcctgga atatttgatt 36960 ccaatgcgac actagcaaat gatgggaacg catatccttc atcttcattc ggcgatttat 37020 tcaaacaaag cgcccgtatt gtaaacgcat tctttggagg gacaaaccaa acatctcgtt 37080 ccctgcaaat gatgtgtatg gtcgcatctt tacctggtac agggattgac actactccca 37140 tgaccaacaa cggcaaccac attaaaatgc cgaacaacaa gacgaacatt gatctggagt 37200 tgtcgttcct cctcgccaac gattattatg aaaagtcggt catggacaaa tggaagaatc 37260 tgatattcga cccatacaca accaagatgg gttattatga agatttcgtg accgatattt 37320 gtatagagca aatggataca gaagatcagg ttgttcatcg cgtttatgtg actgaggctc 37380 accccatcaa cttcagttct atagacctgg ataaaagcgc cgccgatcaa tttaatcagt 37440 acaacatttc cttttcttat aacaaagtat tatcggagac tgaatatgaa acgcgcagcc 37500 tcgccagcga ttttcttcct ttgggtatta ctgatgctct tgcttccgga gactgggaaa 37560 ccgctgcgtc aaaagccgga cagctgtata aaaagatcaa agaaggaaac ttcacaggtg 37620 aagccctgct ggcttataag caactcgatc agcttgtaaa caatctggct ggtatcagct 37680 tggctgattt cgaaaggatc tctatcggca tccagaggga tatcttaggc aatgataacc 37740 tgacggcgtc tgagaagagt agtctgttgg gattgttaca ggatgttgtc aaaaactaaa 37800 aagcccccga aggggcttta gcgaaattag tctttcttca ggaactgctc gaactcatca 37860 atggaagccg tctgtttcgc atcggcacca ccattattgg ctggaacaga ttgctgtgca 37920 ttagaaggct gagattgttg ttggttcaga ctttcctgcg ctgttgggcg ctgtggttcc 37980 tgagactggg taggcgcatg tgccatagta gaagcaccac cttcaaccag aggctgatta 38040 tcagggatgg ccagaacttt gcgcaaacgt ttttccagat cttcgtacga tttgaagttg 38100 gccggattaa agaactcaaa cagactgtgt tctttttccc agatctcttc aatgtattcg 38160 tctgtcccca aaggtgccgg agtatcccac ttcacattgg tgaagttggc caccagacct 38220 ttccagttgc cgaactcttt ctcttcgcca aagaggttca gaatcaggtt cgcgccttcc 38280 cacatatcga acgggtcgaa tttagggtca gttgagaact taggattctg agccgaatcc 38340 aggattttct tgacggcatt accgaactca agcaagaaga ccttgccgtt gttttccgga 38400 ttgttgccat ctttgatcac caggatgttg gcgtagtatt tggtgtccgg cagacgtttt 38460 ttgagaactg ttttcagctt ttcatcattc gtttctttct gttgtgccca cagaggacgg 38520 tcatggtcac gaacaggatc atcgttaccg aaagtctgcg gagagttttc gatataccaa 38580 ccaccagcgc cctggaatgc gtgtttcatg atcatggcac acggagttaa cacagcatct 38640 tcagggatgg tgccttcttc tttagccttc atgtccacca aagggatcga caggaaacga 38700 atgatgtttt cagaagtacc cttgtcattc caggtccact tccagggg cgggtcacga 38760 ccgccaccaa cacgctggcc ttgctgagcg agtcgctgtt gcatagcttc ggcttgttgg 38820 ccacgagatt gtttaagacg atcaaataaa ttacccattt taatattcct ctataatccg 38880 ccccttcggg ctattctgta aatgtatttg tcaattattc cgacggtgta attatactgc 38940 gttttgctat tgagttaacc cgcaatcatt tgttttgctg ggtctatttc aataatgtcg 39000 tacacatctg agaaggtttt gtgtccttcc aagaatgtat ggtattcgat gacataggat 39060 ttaccttccg gcgtcgtgta acgtacacga tccatatcat cagcatgttc attgaggcta 39120 ccgtgccgcc agcggataga acctggcaga tactcttgcg ccttcaacat tttatagatt 39180 tgctctttgc tcatgttaca accttaaatg agttttttag atttcaattc acccttcaac 39240 aaccgagcat cagaacattc agctgttagc cttgacagaa gaggaggcgt gatcaatttt 39300 ttgacctttg cttcttcgat gtcatactct tcacaaacac tggccatcgt ttcaaggatt 39360 gattccttgc gttggcttgc tctcatcaac accaattcgg aaaaagaatc tggtgtgagc 39420 acttgtgcta tttgttgatc agacatcgat tgtattcccc ttccctgatt gcttcttaat 39480 atgacgcaaa acgtctttga agccatcagg cgcggactga ggaccacgaa caccagatac 39540 gatctttggt gctccaataa tcatttttat ttcaccacca cattcagaac atggctctaa 39600 ttcaggtgta tgacgttcag cacaagattt tcgagcacta aacgaatttc cacaacctgt 39660 acaggcataa tcataaaacg gcatgaatcg cctccaatac gtgtcgtaga aatataataa 39720 ctgctcccac cagcgtagaa aacaggacaa tcctgattgc tttgtcacgc agcaaaacat 39780 attcggccaa catatcagat tgatttgcag ctcttacatt gacgtcacta tgtggcgaaa 39840 ccgcatagaa agataccatg gcgcttaatg aatgaaggaa tgtcaagaat cccttaatcc 39900 aaacaaacgc cgtcatcaac agcaaggcga aaagcagtat atctgccagc agccagtagt 39960 taatcatttc ttacacctct attgaaatca ggataatttt ctatgaagta aggaccagaa 40020 accatatttg cgaacgaatc cacgaggtca tcgattggct ttggatcctt tacgtccaac 40080 atgtccatta taccgcgcat cttaacgttg aacagcttct caaagtgatc tatcatgacc 40140 aatttgtcgg catttccttt accacaaaaa tgtttcttaa caaaagacgg ggtaacaatc 40200 tgaaattcca tattgttccg gcgcatcgct tgtttcaata gagatgtgtt ctcggcggtt 40260 tggcatatgt tattggagtt ttttgaattc cccatagcat agccttctag ggtgatgaaa 40320 tccggcttct ccgtaagaag tacggcttca gcccatttgg aaatgttata aaaccgttct 40380 tcgggggatt catatttggg ttgacgtaaa ataagaatat tgtgtcgcac ttgacgacaa 40440 tgcttctcaa cggtatggtg tgcatagaaa tgaagatgat caaaatccag aggatctttg 40500 tcgtcccaga agcacatggc tggacagccg taagaatagt cgattccgca aaatttcata 40560 aaaaataccc ataacgaagt ttcattgtgt tatgggtatt tagaccggat tatctggtga 40620 cgattttgct ttccggtaaa atcaggcgag gtttggagtc catttcttct tgcatctgac 40680 gtatctgttg cagtaatgca gaagtgtcca catgacgttt gatccctcgc gcctcatcac 40740 catatgacac atggccgttg gcgtccacat aatgcgcggt gcaaaccatc aaaacataac 40800 ccaactcacc aacggcaacc gttaaatcaa ccacttcgga agccaaagat tctccgtcaa 40860 cactgagatt gggtgaataa tggattttac catcagccat aaattcgcta ttcagcataa 40920 tcatgccagc gatcgtttgt acaacggggt tcccctgatc atcagcaacg aaaccgtcga 40980 atgcgccttc aaaccctggc gcaatttctc ccttttcatt tgtgatcaca gcgcgaaggc 41040 gttgaaggat gacgtcttgt acctgctgaa tatcagcgcg ttctacgttt ggcattattg 41100 ttctccagtt cataatcccg ttctttaaca tattcataaa gacgggaagt aattcggtcg 41160 gcattgcctg tagtattctt cacaacccaa ccgctcgtaa ggacatccat tttatatcca 41220 caatcattat cttgaaaata acttttaatt gtttcaagac gacgacgttt atgaaaatac 41280 ggtattaatt caccgatgat gatacaatcc ggatagtgtt tttccagggt gttaatatct 41340 cgttgcaccc aaaccggaat aacatcatcc tcttcaattg ggctgtacgt tggatcaacg 41400 ataatcacat tgaatccata attcaataaa tctttaactc ccagccaccc gaatttcata 41460 tcggacacgg tcatggcgac attctttatc cccaatttat ttgcaaaatc tgtgagtaat 41520 acaaaaaagt ccgtgtttgc atccggataa ttaattgcga gttgctcccc cactttactg 41580 aaacagaacg cgtgcatttt cagtcctcgt tataaataca attacaatat accgtggaga 41640 tacattatga atttaccatc attgcccaaa actgagagaa cacataaaag tgatttctgg 41700 ccgactgtga tcaaataccg cgcctttaca gcagggcaac agaccatgtt acttcaggtt 41760 gctgatccga acactcctat gagtgagcgc gtggcaacat tggagcaact atttgacagt 41820 tgtgttgatg ctggcgttcc ctttagtaaa ctgccaatcg gtgttactga agaagtattt 41880 ttaaagatgc gctgtatatc tatcggcgag gtcatgaaga tacgttacaa atgtaacaat 41940 aaagttcaag ccgacacaaa tgaaggtgaa gaaccagttt ctggtgttaa agattgtggt 42000 caagagcttg tgttaccgat cccgctcaat caggtaaaat gcgtgtcccc agaaggcttc 42060 agggagacgt ttgatctacc aggtggttat catataaaga tgcgccagcc gtccttctcg 42120 gatgcctcag tgcttaatga agcatcctct gttgaacaaa tgattgccac ctttatcgat 42180 tgtctgtatg acgacgatgg tcaggtttgg aaggtggaaa atccggctga acctggtatc 42240 gatccagaag ttgctaaaga acgccaacgc attaaggatg aatttgtcaa atgggttggg 42300 gacaatattg aatctgagat tgttcaggac atttcgaatg atttctttaa aaagattccg 42360 cgtattcgtt acgcgacaaa aattaaatgc ccttcgtgtg ggaaagaaca cgaagtcaaa 42420 tttaacagtg tcactgagat tttcatttaa tttttgaaat tgatttactc tcctattttg 42480 tgatgtgtga cgaattaaag gcacacggct atagtatatt tgaaatcagt gaatcgatgc 42540 cgtggcatct tgatttgctt accgagacac tgaaaattag attgtctaag aaatcttcca 42600 accccacgta atgtggggtt ttctttgctt acctgtatta ccgtttaaga aaggattgtt 42660 taacccgaaa ttgctataac accgttgttg ctgaagtaag tgttgtgtaa atctgttttg 42720 aatttgtttt gaaacaaaaa taatgctttt ctacgcatgt tctgaggtgt acagtatttt 42780 cctcgccttt atgcctccat ggcattggaa tgggactgcc tgtcaaggcg gtgttacgag 42840 cttcagcgag taggaacgaa aagaataaag gttgaacgga agcagagctt cctataatat 42900 attattcgac agatttcaaa tccccgccat aaatatcaca tgattctaat tgactaatgg 42960 gtttcaatat gttagacaac ttgcgttggt tttacgggcg cgttgaagac gtgaatgatc 43020 ccgatcaaaa cgggcgcgtc gcagtacgca tctatggggt acacacggag gataccactc 43080 tactgcctac cgaattattg ccttggggta aaatgcttat gccagcatct aacgcctcct 43140 cggcaggttt aggctggtct ccgacgggta tcactgtcgg ctctgacgtt atggggtttg 43200 ctttggatga agcatatcag aacatccgta ttgcatgggt atggccagca gcaacaccaa 43260 cagatgggtc agatacaaac ccgttggcgc tgggtcaggt cgttcaatct atagaaaggc 43320 agaagtataa tgccgtcgag aatgttcctg ttaagattga ggatgaacca caaccggatc 43380 cacaaccacc agtagacgga tatgatcctg agaagtggat gaccgtggct cgtggggaat 43440 tgggcgtcaa agaatattct ggtaagttca ataacaaccc aaggatattg gaatatcata 43500 agacaacttc cctgggggcg tcagaagatg aagttagttg gtgtgcgtcg tttgtcggat 43560 gggttctgat acaggccgga tatacatcaa cacgttctgc tttggctcgt tcatatttac 43620 aatggggatc tcctctgtca gaaccacgtt acggcgctgt tgtagtgttc cggcgcggga 43680 acaacccgac attcggtcac gttgcattcg ttcagaaatt tgacgccaac tacgtttggt 43740 gtatcggggg aaaccaatcc gattcggtga aggtgagccg ttttagccgc tcatccgtgt 43800 tgggttatcg ttggccaggt ccagaaacta cagcttcagc agctccggca caacaaaacg 43860 gtaaatggtc tgaacctatt ccagatcgta ccccgaaagt ccaagaaaca ccgcctcctt 43920 ctggtcgtgt tcaggatatt gacaacacag gagaggtatc ggttccttcg gctggggggt 43980 ctcgttatcc atacaacaat gttatggctt ctcgcgctgg gcatattatg gaggtcgatg 44040 acactccagg cggggaacgt ttgcattgga tgcactcttc tggttcttac aagcaaatgc 44100 ttcctgacgg tgatgttgtt aataaatcag tcaaagatca ttatgacctg acgatgttcg 44160 acaaacgtta ttatgtgggg cgtgatcata acctgacaat tggtgggact gaagtacagc 44220 gcaagacagg agaagtttat cacttacact cttctaacta ttccaatgtg gtcgctggaa 44280 cagcgttgat gaaattttct caattggctg agatacaggc acagaacgtg ttgcgtctca 44340 tctgtgaaat gtttgaagtg tctaacactt tgaaggttcc taagatactg gcaactgaaa 44400 taatttgcga taaattatcg gtcgcacaga ctattgaagg caacatcaaa tatgctgaag 44460 gcgctggtcg cgccgcctca cgtgcggggg caactcctgt aacaactaca ggcccaggtc 44520 caattgatat aaaaccggag ttagaggata acggtggcaa ttttggtggt aaaggcgcat 44580 gattacactg gtgagggcag ataatgccct ctcgtgctgg agaggcaata tccaaagggg 44640 tttaacatga aagagtacaa ggacattgac ctgaagtttg gcatgcatcc ggtcaccaaa 44700 gatgtcacta agaaaacagg catttatgct gtactacaat ctgtgcgaaa tatcgtgatg 44760 tctacagtag gtgattggcc gacgtatccg agtattgggg cggggttgta taccatgctg 44820 ggagaaaaca caaatcccac gatacaggtc gacgtgaaga acaaagttga agatgccatt 44880 gctctttttg agccaagagc tgaattgcaa tctgttgatg tatcattgtc tgacgattat 44940 cattctctgg gcgtaaccat cacgttctat gtggtcaaca acccagagcc gataacagac 45000 accatatggt taaaacgcac aaactgatta aggtgcgttg gtattgcagc ggttggtaat 45060 tatttcaaaa tgcgtcagta aacggtacaga taatttccca cctattctat gggctatggt 45120 gt; aatgcgaagg atatcactgc cttcagaacg cattatttga cagtcatggc tgtaccctat 45240 ttctttccct ttgaggacaa gaggaacatg tgcgctttcc tttaacaggg tatctaaatt 45300 ttcaaataaa ggttcttctt tgttattgac ggaatacacc gtctctaata tcgggaattt 45360 atacatatca tggcaccaac gtaatcacaa tcatgttgag taccgtatca accgcgacac 45420 cagaatcctc ttcatgtatg gttgaggcgc gcaagtggat atctgaaata taattgtcta 45480 tatgcatcga cgtcaaataa ggacggtgtt gatacacagg acggttgacc tgaacatatt 45540 cacgcagaat gctgaatgaa aagtcttcac attgagtggt gtcaatgcgc aaaaatcttt 45600 gagcatggca ggtctttaac tcggtcactt tccccaaata atggaggtct ccggatgaac 45660 cgatacggaa catcacgtct acttcagatt tgaaaatttc gcgttcaata agggtcgctg 45720 gtgcccaaca aacttcttcc ttgtcttcag caaacaacgt atcgatcact tctggtaatt 45780 ggatataacc aaagttgtgg cgggggttgg tgagtaattt gttggacata ttatgctcct 45840 attacgtgct gtttggcttg ttcataggct gtgcggagtt caagataaga atctgccaac 45900 aacggtgatt tgtcgttttt ccgattcatg attatttggt ggttaacgac agcacggcgt 45960 aatctgagtt ctgccaccca gaatgctttt tgtttggcgt gtcctggacg ggcgcgtagg 46020 tcgtgataat gcatagaagc atgatatatt tcagagttgg tcatgatata gttcctgcta 46080 ttcaatttgt ggcgtttgcc aatgaattac tgggaagtat aggcggaaag gtttcaaaag 46140 taaagcccct cattgagggg ctttgaaaga tcagcgtttc aaacttgcgg cgagtccagt 46200 aacgtcggtc acggtttggt cagccagaac aatcacgggc atagacatgc gttgcttacc 46260 agtgattttc tgtaattctt ccagcttgta gtctttgtct agcttcagaa tttggtgttc 46320 aataccgcga atgcgacaga tgttttcagc ttgtaaacat tgcgcacaac cttgtttgga 46380 ataaatcgta atcatttctc acctttaggc aaatttcaga ccgtcggaga ctgatccagt 46440 aaggacacca gtcagataat caggagcttc cgcttcctgt aatgcatatt gcattgtttt 46500 attatctagc cactcattta tccatggcac cggattgtct ttacgggctt gtcctgggta 46560 tgggtggcca atagccccca tacgatgtgt tgccaaccag tccaccattt gatgaaggat 46620 attggcattc agtcccagca ttgagccgtc tttgaacaga taattcgccc attctttttc 46680 ttggttgaca acgtcgacat acatctgggt catttcgccg cgcagttctt ctctaataat 46740 ggcaaaatca gggtccaaca gcggcagacg gttcaggaaa gtctgggtca ggatgaggtg 46800 atcttgctca tcacgagcaa tctgacggat gattttagcg ttgccttcca ttttgttgag 46860 gaattgcatg aatgcccaag aacacgcaaa tgaaacatag aaacgaacgc cttcgaggga 46920 gttagcagca aacagagcac gccagaatgc acgcttggcg ttcatgatgt cttcacgggt 46980 gaacgcgcgt ccagccatac gcatcccgct gtaacgcacc atgtcgtcgt agtacacgct 47040 gatctgtccg gcgcaatcga cgatctcctg aacgtccaga acatggtcaa aaacgatacc 47100 aggatcattc actgtgttac gaaggatatg cgtgtaagat agtgagtgga tggcttcttg 47160 gcgcgtccac tccagaatag caaattggat ttccggagtt gatgcccatg ggccaaacgc 47220 ttcgaacgga gcagcgccct gaatagagtc cagcatggtt tggcgtttca ggttgctgaa 47280 gtagatgtgt tgttccgcag cggatagagt ggcaaagtct gctttgtctt tggtgacatc 47340 cacttcttcc ggacgccaga actggctgag acctttctca taccacttct gtacaaaagg 47400 ccatgccacg atgtcatagc gctgaatgct cacagggtcg ccaaagaacg gcagtcctgt 47460 attatctgaa gatgggtcaa atactgaaaa ttgcttttgt tcgttcatgt ttctttcctg 47520 atgaataagg ggtgacgaat cacccctgat attaaacgtt tgtgttgtat agacctaatc 47580 aaacaacaca ggtatcacaa atttcttcaa cttgtttcaa ctcttcatct tccttggagt 47640 ctttgttggt gttgtaatac agagttttac caccccacat gtagaaagac agaatatcct 47700 gcatcataag agagcgcggg atcttgcctt ctggatattt ctctgggtca taccatgtgt 47760 tggtactgat agattgatct acccaacgtt gtatgaccgc agccgtcttc aggtattcaa 47820 tacaatccag attccatttc aggtcatata gaggaccaag ggtttcaacg tccggaacga 47880 tctgcttgta gacgccatcc ttgctgcctt tgatactgat gaggcctttg ggtggctcta 47940 taccattcgt ggcgttcagc acctgagagg agctttcagt tggtgctacg gctaacaacg 48000 tggcgttacg gatcccatac tcggataggt tctgcttaag accttcccag tcaagaccat 48060 aggcttgccc aacaggcttt ttgccattgg gtaggatgtc cagcgggaga ggctgaaggt 48120 cggctgttac aaatccggaa tcatggatag ttgacttctt acaagatccg aaacgcatgg 48180 ccagacggtt ggacgctttg accaagtaga aatgaagatg cgccatccac ttgtctagaa 48240 gttctaatcc gataggcgat ccataacccg tgaaattctt ggccaggaaa tgtgcgacgt 48300 tgacgatacc gatacccaga ggacgatatt cttctacggc caaacgggct tggcgagctg 48360 ggtagtcctg atattccaac aacatatcca aagctgaaac cagaacgaaa gcaacatctt 48420 ccatttctgt tggatcttca aatgccgtca ggttaaatga tgcgagtgta cacagggcaa 48480 tgcgaccatc ttcatcatca tactgttgga actcacgagt cgggagcgcg atttctaaac 48540 acagattaga gctataaatc gtgtccaaat tgaacggact atactcgttc atgtgatcaa 48600 cgaatgcgat gtagatccgt ccagtgtcag aacgctggtc tagtagcatt tggaacactt 48660 cttcagcttg cagctttttg gaacgacata atccggcgtc ggcggccttg atcatattgt 48720 cgtacatttc gcggaattta ttgacgtctg cgaaaaatgc ttcatacatt tcgcggttgt 48780 cttttggatc aaacaggtat agaggctgtt tgttcaccag gcgctcgaac atgacgcggt 48840 taatctgaat cccatagtcg atacggcgtt cacggttctc ttccaatcca cggttgtttt 48900 tgagaacaac gacatcatca aattgataat gccagatggg aacatagcat gttgccgatc 48960 caccacggat accgccttga gagcaagact tcagggcacc agtcaaatac ttgatgaatg 49020 gaaccagacc tgtatggacc atttcccctt tacggatagg gctaccgatg ccacgaattg 49080 ccccaacatc gaatccgatg ccagcacgtt tggaaacata atccacgatg cttttcgcag 49140 tggcattaat tgagtccaat gtatcaccag ttttgatcaa tacacaagag ctgaactgtc 49200 gggtcggggt gcggacgccg gacataatag gtgttggaag actgaatttg cctgtactgg 49260 cgtattcata gaacttcttc accattgtca gtctgctttc tttatcccac gctgagaata 49320 atgccatagc gattgccatg tacatgactt gaggggtttc ataatacact ttgctgtcag 49380 aagaacgatc acgcaaaaga tatttttgag tcagctggcc cattgctgcc caagtgaaat 49440 tcttgtcgcg tttgtggttg atgactgtgt taagttcttc gaattcttct ttagagtaaa 49500 gttcgaggaa ttcgcggtca taaacaccca gcttggtgtt ctttgcaaag atatccagca 49560 aatggggtgg cttgtactga ccatagacaa ccttgcgcag gtcatacgac ttcaggcggg 49620 cagcaacata ttgatagttg ggtttatcaa cagaaattaa ggtggccgca gcttggataa 49680 tgatatcctg aatgcgttcg gttttcatgt tatcggtgaa ttgaatcttc gatgtggctt 49740 ccacctcaga caccgatact ccttcaaggc cgtcacatgc tcgttcaata acggtatgga 49800 gtttttcaat gtcaaagggg acagaagatc cgtcccgctt tatgatgtta atcatagcga 49860 tcctcggttt gtgtttatgc aggctgttat tatacaccgc ctccatggat tgaaggcggc 49920 ggggaagttc gtgtggtatt taaatgttgt acaggtcgtt aatttctaac atcaggcggg 49980 tgaagttgcc gcgaccatta cgatcagact tatcgaattc gatgatgctg aatggttgaa 50040 cccactctgg atattcatct ccgatttcta caccgtcaat ttgcaaggaa cctgtttcca 50100 gcttattgtt gaagtcttta aaggaatcca catacgtctg taacgcactg tcacgcagtc 50160 gcttgttaga ctgtttgata tctccattca cgaagatgta cgaagaatct gaagcacggg 50220 tcagtaagtt cttcagctgc tccatatcgc attcctgcgc ctcttcgata atcaggaaac 50280 aatcatcgaa agtcatcccc tttacagttt caaggtcttg aatttctatg atgcgtttct 50340 cccacagata gttgaagaaa ccgtcggaac ccgtatctgt tttgagaacc tttttgaatg 50400 tctgtatgag cggcatcaaa taaggcatca acttttcata tgtatcacca ggccggaacc 50460 ctgctgtggt gccagttgga aggggagaac gcgtgatgat aatcttgttg atggttttgt 50520 caatcagatg ttttgctgca gcagatgcac cacaatagga tttgcctgta cctgccggac 50580 cgatagcgat agtgagatgt tcattgagtg cggattgata tgcgaggttc tgattttctg 50640 agaggccatt gaacggagca attttgaaat cgcctttgga aaacttcatc cagtcttctt 50700 ccttctggat ggtgtctttc ttacgagcag attttgtctt cgctggcttc atggatacaa 50760 ctttagacgc agattgcatg ttgaaccttc ctatatctac aggggttgtc gacaccttta 50820 attaagcgac acgcccagca tacctgtata tcagataaag aaaaaggccg tttccggcct 50880 tgagaattag cagaaactct tgtatgctac cgccagtttg gtgtcatact ggttcttggc 50940 gtatgctgga ccattgtacc gacgggcgaa ctcagcccaa tttttgttct tcagggcttt 51000 ccacatattg gcatcagcct tgatgaactt gacaaatgcc agaaggtgag cgcgttcacc 51060 agtcaggaaa tcagtgaaca tctctttggc atttgaatag ccacagattt ggcagttgaa 51120 ccccatgatc tggaataggc cgtaggaagc actctcgtaa gcgcagtcct cgtcaagggc 51180 gattgcaccc tgaaggcgtt ccaactccgc gtctccgccg atatacccgc cagaattggg 51240 gttaaccaat gttggataga gttggtacag agcattggct cttgcttgcc cgaatttggc 51300 cgtcaccttt ttgtacatga tgtggcgctc aaacagagtt ttgatcttgc cagttttggt 51360 aaaacccgtg ccacgggatt ctacctgatt cacagctttc atactggcca gctcaatacc 51420 aagttcacgt gctgcgtcaa ccaagtccgc ttcggtcaga tgttcctgat gagcgtctcc 51480 agcgttgcgg atagcataga aggtctttgg cccagcaata ccatcaataa ccaatccagc 51540 acctgcctga acggatttga ctgcattctc tgttgcttta ccaaatatgc catcggctgt 51600 aagggagaaa ccgattttgt tgaggctttg ttgaagcgct ttgacttcag aacctcggtt 51660 gccaagtttt agaatggcca taagaaaata cctccgcaat gtatgcgaag gtatttaaag 51720 tgaaagtcga acttgaggat ttagtgtcga ttatctgact acgacgacag gcatgatttc 51780 tttgaaggaa gtcctaactt cggaatcata cccatatttt tcaaatattt tcaacatcgc 51840 ttgttccagt tcctcttgga actgaggaaa gtgcgcgttg ggaattcggt cggcaaccca 51900 tagagcgcca ggagaggctt ggataattgc tctactcatg tctcattctc ctaccaaaac 51960 tttgaaaggg ggaggtttcc cccttgcggt taagccagtt tgttcaccag agtttctact 52020 gcgtcggcgc tcagtttacc cattttgaca tactgggatt tcgcttcacc gccagcggct 52080 ttcacgatat cactgttgtc ataacccttt ttcgggaata ccatcacgga gaaggttccg 52140 ttgttcagcg ggttcagctg aatgcgacct ttaccgacta cgatggtgcc gtaagtttcg 52200 gtattcgctt cgacaacgtg gatgtcatgg cccaggtctt tcagcatgcc aactttgtca 52260 gcagtcttgg caaccacggc tttgtctacg acaacctgct ctaccagggt gaagccgttg 52320 gtcgctttca ctttgccgtt cagcagattc atgaaggaag ttttgccacc agtgaagcca 52380 gctgcctgag cgatgcggaa catttcaact tttgcaactt cggtgttcag ttcaaaagag 52440 atggtgccgt tggtgatcag agttttggta gtagccatga tgtaattcct cataatgtag 52500 ttgggtcgtt tcacttttca ttcggcgggg tgttgtgtac cgccctatgt gaactataat 52560 agtgcatgat tattgaagag taaagtcttt ttcaataaat ttttaaatta tttttgaagt 52620 attttaaaag gcctcgtaga atgaggccta gagagaaggt ttttgagtta aaaagtttta 52680 ggtcggcttc tttttcaaat actggcgagc caaattcatt tgttcttcag tgataggaca 52740 accgccgaag tccaccattc cgttcctcca accatggatg aaactcttag attctaaacc 52800 agataggaca tatccttcac gggcttgcat atacccgcga agaatctctt catcgtccat 52860 actattcagt tcttttaaat ccatcatatc ttcctcaagt cagaaaatcg taaggacgcc 52920 gacagtccct gatatacgtt cttggctatg atctgaagca gatcacgtat cgggatattt 52980 cccttgtcgg ggcgaaccat atcattgata tccttccacg gtatttccgg tggaaacaga 53040 acgactttga ctccgctgtc tatcatcttc tgtataccgt cacaaacttg tttgttcctg 53100 tattggttat cggggatata gatatccccc ttagcactta ataagtcggc atcggcagtc 53160 gcaagacaat taggtagaaa caagctatca attggacctt ctactaccaa ctttgttttg 53220 ttccaaatga tgcgctcttc cccgtagatc ttagtatctt cgttcttagg cttgacagtg 53280 gcataccgta ataccccatc aggaaggtta tcgccgaatg cgcgcccctg aactatcttc 53340 atgcgcccgt cttgggtcca gaatgggatt accagccgct catcttcggg tatcttcttt 53400 tgcttctcaa catccgtttc aaaactcaga agatcttgac gaaaattcct gctgtaatat 53460 aacaaagata acgtgctctc cggcattccc ctgccttcaa cgtaacgacg ggcgatatga 53520 tcacggtcaa gaagatcaag gcgtatcata ttcccaaggt gctcttcatc ccgtttggcg 53580 acctgagaac cgatacgtgc tgtctgggtc aggcgctgta atggtttgag tttttgtaac 53640 gggcgggaac tggtatcccc cattatcctg aatttttcaa ggttgtattc attatacaga 53700 cgctcgtcaa acttcttcaa ccagaattca aacgcccaac cgctcatttc attacagttg 53760 tggcacttga aacgaaacac atcgtcatca cgatcataaa agaagtgacc acgacgcttg 53820 ttggcactct tcttagaatc cccacataat gggcaacgaa atttggcgac agcgccaaca 53880 cgttcccaac tgaatttatc aagtcggggg gcgagaaaat tgatgtattg ttcgtccaag 53940 aatttcatta gatatttggc ctctggaaca cttctgtcac attataatcc accccgcgac 54000 tttgagctat gcaaagctgt cgccaagccc catacagaat attttgttcc gcaacctgat 54060 tgcgttcaaa gcgggcgaat tcttccagca tctgtttgta ccctaataga taaggaggga 54120 tatctatagg tcttcttttg cccaaagatt tagacaaata tgatgcataa tgttccggtg 54180 aagacaaaga ggaatattgc atattcggaa cgtgaacggg cttcaaagat tttctagggg 54240 tgaagtacaa caaaccccac ttgggaggga ggtcttcaat tttaataaca tctgctgggc 54300 aaacatagaa acgatatgct cccatgccta tggaaggatt catgcgatga ggtttctttt 54360 tgtctgtcag gaagtcggcg cgggagactt taacttccat taatatagaa caacccccag 54420 gtctgaaccc gatggcgtca ggggattcac gattatcgaa tgaatttggt tctacgaaca 54480 cagcaccaca attcatttgt ttgtgtagaa attttgcagc gatttgacaa ccttctgagt 54540 gagaaggtat aaagattttg cccattgtta tctgtatcct attgatgacg aatgggcaaa 54600 attataacct gacgatgatc ctattgagtt aggacaattg cttcagtttg taaatcgttt 54660 gatagcacaa agttttgatt tcatcaagcg tattttgaag atggctgtcg cattgaccat 54720 aaattccgtt tacgtcgata acaacactgt tgacatacga tataggatct gggttgtaca 54780 gtttaatatt ctcaaaccct gggacatata caccacccgc gccgatatat gcctctgtaa 54840 aggtatccag caagtcctcc agttccccgt agaactcccc gagtgccttg tgcttggcat 54900 aggacgttgt aacgaagtgg agggcatgag agtgggctat agcaagcagt ccacggttga 54960 tgaatatact cgcattgacc atgattgttt cctcagaaaa agaaatcccc ctgtatttag 55020 ggggattgtc atcaaggctt gatcaaagtc agcttgacgg tttcacccgt gctggtgttc 55080 gtcagggtca taatgttctg tgcgttcaca gacttcactt tcccctgatg tttatccccg 55140 ttgcgatcat agtaatcaat cagatcgcct ttgttagggc ggccaacgtc ggtgatgtca 55200 tacatgccct gctgtccaag acggcgatgg tcaacctttg cttccttcaa gaggaagtcc 55260 tggaatcctt tcatacaacc tccttagaca ggtttaacgt caatatattt ggcaatgtcc 55320 gcagctaggg ttttcccctt actgatgtca tgctgtttgc cagcgactgt gacaattaca 55380 tatggatcgt cttctccgcc gaagtcgatt gcgacaggtt ttccaatacc aggaataccg 55440 gaatattcaa actctgtacg accgctttta cgagatttgc caacgcccag cgctttaccg 55500 atcatcttat ccatgttcgc caattcttgg gcataggatt ctgtgacctg acctttgctg 55560 gcatctttcc caaagaagaa ctcaaaaccg tcatgaacgg caaccacatc tttaccgaca 55620 gaaactgcat gaacctggtc cggtgtgagt tttactttgg tggtgttacc gttagtcaat 55680 tccagattat agatgtcggc ctgattatct ggagtgatct gggttacggt ggcaccagta 55740 caccattggg ttccgtcggc ctgtttggtg atggttacac ttttgccttg tatgccgcca 55800 tgagtttgcg gttgttgagc ttgttcttta aaatattcga taaacggttt catcgtggat 55860 ctcctaagga ttttgatgta tttagccccc gaaggggcta tgacttattt cagactaatc 55920 tgaagattac cacccagcga ttgttcatat tcactgtatg cactatcacc attactcaca 55980 gcccattcgt cggattggcg agcgcgttca agagtcatga gatttggctc ggtaggatta 56040 tagcctttag atttcgcgtc gttgtatacc gtttgcaggt attggttggc acggtttatc 56100 tgatccttga attcacgata tgctccttcg gtcgtattgc gacggaaagt gatatcccaa 56160 gcaacattca gaactgtacc attactggct gtgtatacct gccaatccag atctcgtcca 56220 ttaggagcgc tatcacgaat ggatccggca taggtggcca gatcacctgc attcttacct 56280 ccagcagcct gatctttagc ccgagccaga gcatcaatga ctgctgtgcg gttcctggac 56340 tgtgccaaat ctttgtcttg gaacataatc gcaccaaatt tactgacagt gatgtcattc 56400 aggaatagat tgttagggtt atagtttgat gaactgaggt ggctcagttg cgaagccgcg 56460 tctttcaagc gacgagaaat ctcgtctaac gcatcttgca ctgatttgac agacaacgaa 56520 atatcatatc cattgctgtc tactacattt cgaccatttt cggtcaacat ggtggtgatg 56580 ttggctttgt ttcgatcaaa atcgtaagtt acgttggtaa cgaatcttgc ggcttgcaac 56640 ttgctgccag cagggaactg gaaatcccac gccacagaga agccatgaac ggtttcacca 56700 aaaaatttag cgttgcttgg tactttgatg tttgcagtga tcactgcatt ttcactggaa 56760 ttggtgttga tttcaccaaa gatagtacgc tcgccggaag attgaaccaa cagagtatct 56820 tttccacgcc aatcatagcg gactttgaat gttgtacgag gaaactcttt catcagatca 56880 agtttgaccg ccttgcccaa ggtaaaccga ttcagcagag cgtcagcgat cttcaatgtg 56940 aaagaaccac aatcaacgta agaatatccc tgggaacggg aaattttttg aatcggatat 57000 ggggcgttat tgataggaac cacacggcat tctacttctc cagcaaattg agaatcggct 57060 gcacgggaga ttgcgcccac tatttcataa gcggcgtttt tcacgtctcc ttccagcata 57120 agttggtcat gaccagacaa atctgatact acttctacag aaagttttcc gttgacaatt 57180 ccccagaaat aaacctgaat gtccagacca cccgaagtac gatatttgcc cgcaccgatt 57240 cgtgttagtt tctcacctgc atacataccg acctgttgtg gagcatatgt atcaacgata 57300 cccaagatgc gggcgatata accctggttg cgcagatcat ccatagaacc ggtttttggg 57360 agagttttca tgtcggcggg tgtcaagttt gtttctctag aatcttctac gtttagattg 57420 aacaattgtt tcccagatga gtcggaagca ataaattcat atttcttgcc actgcgggta 57480 ctcgtgctgt taactttgat gtttccagtg tatcttcctg gattcgtttt ttgcatgaaa 57540 ttggtaattg cagcagaagg ggttttcatc ccagaaatga ttctagctgt ctccggatca 57600 gtgaaagaca ccaccaattt acgcccatcc attaccgata cttcatttcc agaaactgaa 57660 atattcaagt tttccatttc agaacggaaa tcgatgccaa caataatagt ttggccagtt 57720 ccacccacaa cgctatcaac gctgttctga accggaacgt cacccacctt gtctggatca 57780 tcccaggtaa tgccctgcat cttcggaccg tcaaatacct gagcaggatc cttgccttta 57840 cgcacaaccc atacgaatgc acgatcaggg ataggggtat acgtcaggtc catgacattg 57900 agcttctgct tcaggccgga ctgacggatg atcttcggca ggagggtaac accacgttcc 57960 aatgctttct tggagaagtt aattgcaaag ccgtcaatgg ttttccccaa aggcgtcgcc 58020 atgaattgct ttgttgcttc aatcatggat gcgatgacac gcattgggtt tttgaaacga 58080 ccgatggcat cgggatatgt ggaaccacgc ttctgaccga taaagacttg gcgaacattc 58140 ttgcctagac cttgtggggt atagaattga atacggaatt ctttttcgtc ttcatcaaca 58200 aatgtgaaga aaatgtcacc agcgttcttc ttgccgaatg tcaattcata cggggatgag 58260 ttaaacgctt cgtctaattg tttagactct tcaagaaagt tcaagaaaga tgggatggcc 58320 attgtaattc tcctgattat aaaatcggtg cggtttccct taattagcga aaagaaaggg 58380 gtgcttctta acgacgaaac gggcgagacg cattttggcg attgttgtaa ttcttatcaa 58440 attgtgccaa cgccgccgga ctccattcgc gttcccattc tttgtcaact tcggtttggt 58500 tggcaggttc aatcatttca gcagtaggaa aatcgcgttt cataatttca cgcaattgtt 58560 cgaaggggc ggtttgggcg tggactaatt cttcaccgtc gtaaactttg gccatcaacc 58620 attttctgcc gtaacggata tatgcgtcga ggatgatttt cataatgtag ttcctgcttt 58680 tcaagttggt gtcgtactgc ttatgtttag aattatactt gggttattga agaagtaaag 58740 gggcttttgc cccttttatt gaataattta aggtgttgga ttgacaacgg gaatatggaa 58800 cctgatccca gagacaatgt ccttcaattg tggctgccaa cccgtgacca aacggggtag 58860 cgcattagaa ccaggataga caataatgat gtcgcttccg gttacattat gttgagggaa 58920 ttgtgacatg tattgctcca tcgtcacccc tgggtctatc aacacaggac cgacatccga 58980 agatgcatat gttgccccca aaccgtcgac gccccatgct agtattccat aatcaggaat 59040 attggcttca gaagttatgg tgaatccgaa gatacgattc agcgcagaaa aatcatacac 59100 gccgtgagca ctgtcatatg tcagataacc ctttgacagc atatcagcga atatcgcgtc 59160 tgtgtcacca gttgccggag tcggtatggt aaacaataac tcaccagcag gaggggatgg 59220 atacgtgccg agtgcataaa ggcaccaagc gtcgatgcat ttcttgatga atgcttccgg 59280 cgcgacataa tccgcaaggc gcattgtacc ggaatattct gaagtaatga tcccttcctt 59340 cgcgccctga atggccagaa ataccattat gtgttcatat ccggtctgag atggagtgat 59400 attcattatc tggtcctctt gagtttctca atcgtgcgct tattcatggc gatcactcct 59460 gggtcgacct ttgggtttat tgccatgcct ttgaaagaca cacatcgttg aagatattta 59520 gccttcttca cgacgtcggc tgcataagaa ttggatttct ggttacgatt gaacccagca 59580 ttgtaagagg aaagggattt gcggatgttt tggttatgat attctagcca gaaattcatt 59640 tcatcaaggg cagcattggc agcatattct tgattgacca gtaatttgat cgcgacattg 59700 gcgtaacact tctgcgtttt gcatccctcc cgtttcccga cggtttggac gcgattttga 59760 aatgccccca tattagccga tttgaggtta ttccgcatgg atacaacatc ttctccggcg 59820 cggctttccc tccatgatat tgcggcgaga gtgaaaccaa ggtcttgttg ttttcccacg 59880 tgataggctg tggccatggt tgaaagttgt tgatcagaaa actcataatc acattgggtg 59940 gtactttggg aagcgtgcac actcccgctg gcaatggtaa aggtcacgga caaggccatg 60000 gccttcaacg ttgtcatcgt catgatggcg ttccttatgt gtttgtcgac ttgcagctcg 60060 ctggagcctc ctgacagggt taaaagataa agggcacgtg atatttagtg cccttcacct 60120 tattcgtaga tcagatggta tgattcctcg atgcattcca accaaccgta gacaaattcc 60180 ataggatcat cccaagctgt attggaagca atagtgaaat ccccgtccaa gatttgcata 60240 tctgtgtact tgttgaaacc caagacggcg tcaacaacga tcaacccacc ttgctctagg 60300 taacgttttg gtgtcaatgc tacctgatga tgtttatttc gctgattcca taattccaca 60360 gcgatatcac aagcaatctg tatttcatct ttctcttctg acatatgttt gtctcaaata 60420 ttcagtaaaa gatttaccca acttacggaa tagtttaata cgaccgatca ctttgacgta 60480 aacatccccg tggcaggggc gtggtttaca ccagcactaa ccatcatgtc atgtcctcat 60540 aattcgatag atttatcagg aaagacagat tccggtcttc gacaaggtca attgccttgc 60600 gactgcccac agcctcacat gtccaatact tgtaattccc tgcgatcttc atcgccaaac 60660 ggataacgcg tagcttcatc tggtactggg cgacttggta gcggacacgc gtcttcttgc 60720 gccagcattg attctccgct ttgtacttgt agaggatcat caggcgaacg gctttgtaca 60780 ggcgcttttc agcgcccttg gatttctttg atacacggat cagacttccc atgatcaatc 60840 cttcttaatc acttcagtca tgccattacg cagaccataa cggatgttgt gtgggaaata 60900 ctcttggaat tcctgctcgc gttgactgat aacgaacaga ttgttcccgc caaatttatg 60960 cttcagcatc tcaaccgatt cttgtacgcc gcgctcgctc atgttctcaa ggatttcatc 61020 cagcacaaac aggttacatt gcaccgacgc cttgaggttt gcaacatctc gtaaagctaa 61080 tgtcacagcc aggttcaggc gactacgctg accagtagat aacgagaaga tgctttgccc 61140 tttacgacct gcagcgctca tggtgatttc aaatgtatca tcaacagcaa tatccaagaa 61200 catattgagt gcttcaagat actcgtttat tttactattg aggaaaggca aatacaggct 61260 gataattcga gccttggtct gatcatcttt taggaagaac agaagatggt tcaggtcttg 61320 caatttctca tccaactcta cgcgccgcgc attcagatct tccattaatg ccgtgatgcg 61380 agcgatctct ccttccaggg cgtcagttgg tgtcggctta accgccaatt tacgctctaa 61440 atcggcaatg gatgcctcta gagggacacg gcgtgatttc aggctggtga gtttatcagc 61500 cgtgtcgttg atactcttag agagctgctc acgcgcttga cggattgacg tcgtgatatc 61560 ttcataacgg gtgtctacgg ccttgaggac gtcgttaatt ttggactgtt gttcccgctg 61620 taaagatgtt ttctcaacag cagcgacatc atagaatcct tggatgtcgc gttttaatgt 61680 agcgatcgct gattccgctt ctcggatttc attgcgcaaa gcatccagtt ctttgtcaat 61740 aaccgaaatc tgagaagata attctgaatc tctgacattg taattctcaa tcagggaatt 61800 cacttcttct agggctgtat caacctgaag aatcttgtca gtcagttcac tgatttgtgg 61860 ataatattga ctttcaatgc gtgatttggt atcgtccgac actaattgcg tacacgtagg 61920 gcaagtgccc atatcgtgga aacgtttgat ggcagattca tgtccttcca tttctgttac 61980 gaatttgata cggaagttct caccctgctg acgccgcgct aatgctttgt tcagttcatc 62040 caggttagca ttccgttggc tgaccagatc atttttacgt tccgcgacta ccgccattct 62100 ctcccgaatt tcttgtaatg aacgttctcc atcagacacc tcgatacgct catagtcttc 62160 agccttggta tcagcctcat cctgaaccgc ttgaattttg gcaaaatact cgtcattgat 62220 ggaatcgata tccaccttca tttcagcgtt caggcgatta cggacttctg ataattctga 62280 tttcaattta gagtcttgag cacggaattc cgtcagttct tcttgagaag caccaatatc 62340 tgaattcaaa ctattcagac gttccttctc ttggacaagg atatccgcag attgttgctg 62400 gatcatcgca ttggaattat tgatctgttc caactgcgct tgctggcctt ttaaatttac 62460 atcatgaaag gcgtaatcat tggtgaccgt cgtgagttca ttcgttactg tcttgataga 62520 tgcttttaca tcttcattca tcaaactgaa gaaccccaaa tcccagattg tctctaccat 62580 agcgcgacgg tcggcagtgt acatttccgt gaatgggatg aacttctctt tgcccagaac 62640 cagggagttc tcaaacatct tctggtctac gccaatcagg ttcacgatat atttgttcat 62700 gtcggctttg gccgcatcat tcacgacctg cttccactga ccgtctacca tctgatagac 62760 ttctacgaaa tcaggtttga taccacgacg gactttccat tcacttccgc gagtagagaa 62820 ctcaacttca cccacgcatt cctttttgtt ttgggaattg actaatccgg ctttcttttc 62880 tttcttgctg tatgtgtcgt tgtacagaac gaagaataac aaccaaacaa gcattgtaga 62940 tttgcccgcc ccattgtcat cagatgtgac tagggttgca gggttgcgtt ggtaatcaat 63000 ttccatgaat tcattaccga tggaacggaa gtttttagcg cgaccgcgat ggaaagtcag 63060 tttgtgggta atttccccac ggatttcaaa tggtgcttca acagaaacag gagtgtccgc 63120 ttctttcaac agcgaaccaa attttgataa taggtctaca ttgctcatta ttatgcatcc 63180 aatgtgttca ggcgttgttg ggcagcatta tagaattgtt ctgctaattt gcaaacattt 63240 tcagggcgct ggatattatt ggcggcgcgg atatctttct tcaggacttc cacagcatca 63300 gtcgccacca tctcttcagt gacttctacc ttctcggaag caacagtaat cgtccgatcg 63360 atgaagttgt aatcgatgca tttacagcgc ttcaatgcgt cacagaactt ttcataatgc 63420 ttggcattgt cacggttctg tacaatcacc ttaacgattt gcccttcaat acccaaaaca 63480 ttgtttaacc aatcggggtc gatccaatta ccttcagtat cagaagacat ttgtgtgtag 63540 tcgtattcca cgaaccggaa caacgtttgt tgttcgttgt tggggataaa caattccccg 63600 ccattcatgt cgtctacata gaatcctcgg ttcgtcccgt ctttgtggtc ttcccaggta 63660 aggtgataag gagtcccaat atactgaatg ttaccttcca tcgaacgggt atggaaatgt 63720 ccggtatcca cgcgctcgaa tttcgaaagg agcgccaagt cgatctgacc tttatcacat 63780 acagaggact ggtacatttt gaaccctgcc aactccagat gcgcaaaaca gtacttggcg 63840 tctgtatctt gtatcgcttt aatggacgca tcatagttct ctttgttaat ccacggcagt 63900 aggagggtct tgacaccttc aatcattact tcagttggtt cgctgtaata atgataaaca 63960 tctggtgcca attcattaag ataagaaggc cagttaatgc gattggactc ttctaacgtg 64020 atatcatggt tgccgacgat gccattccat ttaatacctg ctttgcgcag ggctggcgtt 64080 aattcatctt tcaaccaatc tttatcgcga ccatacatga atttgcgaac atcaaacgta 64140 tcaccaaatt gccacacttc tttaatatcg gcgtcaacca attctggaat aaaataattg 64200 atgagataat tctttatgaa ttctcgaacg taacgggaac cattacggct cccgatatgt 64260 aaatcgccaa ttttagcaat cgccattatt ttgttgctcc cgttctaatg ctcgtttctt 64320 tgcttcttcc caatctggtt ccatagaaca tatttcgtct tccagattga attgagtaga 64380 gccgaagtca tagtctgaat tatcttcggc gtcggcggta atggtatttt cactctttgt 64440 gagacattga agtataccgc gaggaatttt cttattcttt tcctcttctt tgatggcgat 64500 ttgcttttgg cgttcctttt cgcgctgggc ttctttctta gtttcaaaat ttccgatacg 64560 ctcacggaag tccattgtta taccagtgct gtctacgaat gtctgttgct ggaagtctgg 64620 gtcatctgat aatgcagcga aaccacctgc ttcttcaaat gaacgcaact tgatataatt 64680 gtgttcttct tcactggtga gtttcttggc gaatgaacga tcggcgcaca tcgttaccca 64740 agagaagaaa ttgatttttc ctttcttgcc gatatgactg acgtcaaatg tatggaggta 64800 acgaaggatg ttgacaacgg cctcactgac catgtcttcg cggtatggat aatcacgata 64860 gttgtagcgc atactcatgt tcttaataat catctgaaca ttcatggcca cataattggg 64920 gattcttggt aggggtgttc cttcggccaa agcctttttg cgagccggaa tccaatctct 64980 caatattcca acaacacggt cattatcttc gtctgtgaaa tatttggtga cgttatcacc 65040 cctgtctaca aaattcatac ccatcgtgat aatcctcaaa taccaatgaa ttcattgaaa 65100 gaaccaacga ctttcttgac cgagaaacgg ttattttcaa gaaccattga actatcttct 65160 ttggctctaa cgctccactg atccgcaatt tcgttgccca tcgttcctgc atgacctttc 65220 acccatttta attcaagttc acaaattgaa caaactttgt cataataatc gaacaactcg 65280 agcagaagtt ctgtgttctt aggcggcatt ccttcatatt cccatttacg acgccactcc 65340 aaaacgctat tgataacata ttggctgtcg gatatgatgc gggctggggg aatgcagcgt 65400 tcaccgcaat tagagaattt ccataggatc ttcattgcgt ttataacccc gagtaactca 65460 gctatattgt tcgttgacgg cgggggtaaa tacccataaa acactttcca ttgctctcca 65520 gtgattggac tgatggtaaa tgcccaacca gcggctcgtg tcttctgagg ggacgatgcc 65580 ccgtcagtgt atatttcaat catgtataag tatcccaaac tggttttatc gatgaggaac 65640 gaatcatgtc agaacgcgca tatcgtttca gtctgaccgc cccagaaatt gagcgtttgc 65700 tcttgtccat aaacgactcc atccaaaagc tggacatcgt atatgactac acggcgggtg 65760 ggactgaagg tcaggtcgca gctgcgtcag ctgttaagaa catgtggatc aaactcaatg 65820 agatggtcac aggtcaaggt cttaaagacg caattaattc agctgacgac agtaacgtat 65880 tcaccgatca ttataagtct attttagatc gcgaaacttg gaaatttatt ggttctccgg 65940 cagatttatt agcaagggac gatatagaca cttccaattt tgaaggcggt gaagtaatac 66000 tcctacaaaa gaacgcttcg ggcaacccag aattccaata ctggaaaaga actcctgtgg 66060 caggaggtga tccaatattt ggttgggaat ctgtttatga aggaaactcc aacgactctt 66120 ctattgatat tccggttgtt gggaccagca tactgaagac aatcccaaaa gcattgtttc 66180 atatggtcga attccgagta cacgctcgag agtctaccct cggtcattgg caagacactg 66240 atggcaaaat cggttatcgt ggtgaagatc tgatttatag cctgtataat catgttcaaa 66300 ccaaaccgat cgcaaatata tctttcagcc aagatgtgga caatatgatt atcacgataa 66360 cgacacttga accaaatatc aagtgccatt tatcgtttat tgcgggttat taaacctcaa 66420 acactgcatc ggtgaaccag gttgggaaga attctgggtt gcgcatcata agagattcaa 66480 aggatgaatc aatgatgtat gtcgcagccc agtcatcaac acccctgacc gaacgcccac 66540 acatttgaac aatgcgcagt actgcattgc ggaaatatgc cgacggatcc actgaattga 66600 tatgtgctat cagtggatcg cccagataat cataagggac tttgatcagt atttggaaac 66660 ggctgtaatc ccctttgaaa tcataacctt cttccatagc cggactggca atgacgcatg 66720 gggactttgt tctaaaagca ttttccataa tatccatcaa cgcctttcgg gtacgcggaa 66780 catggataaa attctgatat ttgctgaatt tttgtattgc caaggcacga tcataactca 66840 ctgtatggat aatgccggac tgacctgggt ggaacgcgat tatttcatca atatattccg 66900 tcaacctttt catttcatag tcgcccatat tgttagtcat cttcactatg ggcatatagt 66960 tgacttttct gttttcaatc gggatagggt tgccgatctg aatggaatga taatccccct 67020 gtcgaatacc caatgaacga gcatacgaat ctataccaca gatcgttgct gacatatgaa 67080 cgtgataatc agcttttcgg aataacccga attcacttac atcagaaggc ataacgggtt 67140 taaaccgaat aaagtcatct cccttttcct gtacgataaa ggtgctggcc tttgtctgag 67200 acataatacc acaataatca ctcaagttat gcaagacatc tataatgtct gcgagtttca 67260 tcacttgact ttcactcagg cggtcatctt caaccaattc ttcaagaact tccaacaaag 67320 actccacttt aagatggagg tcttcaaaca tcgaatgcat ttcaccagac aaagaataca 67380 acttgcccaa gacatagtcc ttggtgcgtt ctacgatatc ggcaatgata gagactatct 67440 ccttcccttc ggggatagtt cgcagtccgt ccacagcctt tgtattgtat tccattatcg 67500 tgtgctctag gagcgtagag ggcatcttat gacactcgtc taagatcagc atatcggaac 67560 ggttttcagg cttcatacag atggtggtgc acatctcaat catcatagct gcattagtgc 67620 aacgcaatga cgaaatatca gtccataaat tgcgcgcctg tacataagga caacggcgtt 67680 tgctacaatg cccgtcgcgg catgctatac ggcattgcac agcgttgtaa tacacatctg 67740 ggtgtacgtg gcaacgatag ttcttcttgc ctttcaggat gtctatcgcc accgcctttt 67800 cagcagcata ctgatcttgt agacctttgg taggcgtact gatagacgtg cggaattgtc 67860 cataaggatc ggcctgtaaa accaaatgac gaatcacttt atgaattgtt gtcccaatca 67920 aagatttccc cacgccagtt ggggcttcaa tgattacgtg tttgaccttt ttgttgacca 67980 aggcatcaac ggcttcgacg atacattcca tctggcctgg gttcgctttg tcatatggga 68040 attcatcttt ggcaaggcgt tgtatttctt ccacaggaac cttacggcct atggcgtcaa 68100 tcgcctttcg gtgttgatta aatgctgtca cgttgttcct cctttggatt ctgttatagt 68160 ttacccgaat cccaacaacg aaaaagccga ggcattaacc tcggcttctc cttttagcct 68220 tgcgccgctg cactgcagac atgcgctggg ccgacgcctg gtgtgattac tggccgttgg 68280 cagcagcttt cagaccttca ccaactttga atttaactac atttttcgct tcgatctgga 68340 tctgttgtcc gttcagcggg ttgcggccag tgcgcgcttc ctgatgttta acttcgaacg 68400 cgccgaagcc tacgaattgg acagattggc cagccgcgac tgcagttttc acgccattga 68460 taaaagatgc aacgattttc tcagcttcgc ctttggtcat accctgggtt tgggcgatgt 68520 gggcgataaa atcagtacgg ttcattcgga ttactccagt tggttgttta cgatggttca 68580 ctacaagagg actacagctt acctaacaaa tactattgaa taaagcgttt atttgccgac 68640 gtttagcatt ttacttgagc cagaaccatc aacaatcaga gtacatttcc cactgttggc 68700 gcaagattgc aacaccatgt tatattcgtg ttgtaaatat tcaggtgtca gagatgtcgt 68760 cagtttctga ttcgccctgg cttcttggtc gcgaatttca acgttctttc ttgctgtatc 68820 caaacgtttg tcggccatga cattatcacg gatagattgc tcaatcgaag gatctgtcag 68880 cgcctttttc accaacacac gtgtgattgt gaacatgcca ggcgcagcag tttccaattg 68940 ctgctgggtg cgttccttga tcatcttttc taactcagcc cgttgggtgt gaattgtcat 69000 agaatccaaa gaggaaacgg cgtccatcgt tgaggatgct gcggcggttt taaccaggtt 69060 gaatcccacc gctatcgtgc cgtcaccgag ttcagcgctc tgacctgcaa atttggtatg 69120 gaaccaagga accttcgcga cgttcggtgt gtaataaacg tccacatcca gatcttccaa 69180 ggtcaggttg tctttggcct ttggcgtcat tttagtcaga ctcacaacgg cttctttggt 69240 cgtgtaaaca tccacgcttg aaacaaagct ggtgtagatc cccgctgtta cagggttcat 69300 gtccacttca ccccattggg ttcgaacacc gacgtttcct tcatcgataa caccgccgca 69360 gcctgaaaga aggcttgctg ctaggaccat aattgcgcca aataccagtt tcttgaacat 69420 caatgtactc cttcaaaaat gtaaatataa gcacccaacg tgagtgcagt tattgtaacc 69480 gaagaaatca gcagtaggaa agttactctc acccgtttgc gccaacgttt actccggtag 69540 attttagtct ctttcaaata tttgaaaaag aaaaataaaa tgaatgttgt tattacgaat 69600 atgaacagat aacggattaa cccgatcatt ttacacctgc attttccaca atcgcttgat 69660 aaatgtgacg ttcaatagtt ccatcacaaa aacctggccg aaataaacca gctatcgcat 69720 ccaaacactt ctgagtcggt tgaaccggaa tcataatgtg ttctttgtct tcgataggtg 69780 tgggtaaaca aataacctga ccaaccgtga tatggcctgg gttttgaata ttgttgaatc 69840 tggctaattt gatatactgt tgggcatcac catataattt tagagcgatg ctggacagag 69900 tatccccagg ctttacaata tattttgaaa tcatatttcc caccctgtac tgcgcagatg 69960 ctcgaaataa tcgttgagtt cgtcaacatc ttccatatca acccaacgat catccagacc 70020 catatcatta agatcatcat cggtcagatc atgttgataa atctgaatgc ccgaagcatt 70080 gcaataatcc ggcttgatat tgttgttgaa ctggaacaaa tcataatcac ccagagcatt 70140 cttcaggcgc tgcgcttctt caaatgttgg aacctcaaca tgaaaagcga tcccaggaac 70200 ctggggaata tgccaaacgc gaaatttaag ttcaaacggt ttattcgaca tggggttctc 70260 cctgagacag tatggttttc atctgttcac gcgtgataat tgtttcaaca agattctcgt 70320 caatcatcat ttcgtttaac agttcacaac ccagcacgtg tggtcgcgcc atatacggca 70380 tggcgttgag tttttcttct atgtcaagaa cgcgcttgac ggtcaggccc atcgaagaaa 70440 aagggacagg ataaaagaat gaaatgatct gattatccac cccgtttgaa aatcttacca 70500 acaatacatc acaccatacg ccggacatat tacacctcca ccgagtggga tttaagtagt 70560 tcatcaattc ctttctgccc catgtaagag aacggggtac gctggtagaa cgcccacagg 70620 actaattgaa cgacggcgcg ggaacggctt tcggaacgca tctcaagtcc gcgaaaatgt 70680 ggtgattcgg cagtccattg gatctcttca cccaggtctt cgttacaata caccgaaatg 70740 cggaatttat ggcacaacgc gtctacttct ccgtaagcat cagtggaaac cctgagttgt 70800 tctgcatgcg cccaagaagt cgtaacaatc cgttcgccca tcactttgtc agaaacaaac 70860 caatcgatcg attgagtaaa atcatcgaag tgatcaacac gatagataat cccatgacct 70920 tccatacctt tcatggcatg ataacgcgcg tcaatttcat tattgtgcat cgcgttgaag 70980 tcgatgtaaa cccgcctcgc caacacaacg tcttctggct tcagagagac catcgtcgtg 71040 tcattcaccg tgtaatgaag gatgcctgta ccacgcccac agtcatgttg gcaatacacg 71100 tatttgtccc caccaacacg ggcataagca atataacaag gttctgagaa tcgcaggttt 71160 ccttggtctg cgccaaggat gataggataa gatttgtcca taatatagat ctctcaaata 71220 aaaggcggtt taataataac cgccctaatg ttattgaatt attttatatc accaacatac 71280 atgttcaggg tttcatccca ttctaaacga acgcggatgg ttccggaatc gttagggaaa 71340 gacaacttac tagacatatg tttgttggca tacgttccgc tcttgtttac gggataatcg 71400 ttcccttcac taatagcaaa tcgtttaaaa ttccggctta ccatcatatt gatgttcggc 71460 catggtagtt gttcacgcag agttttacac aatatgatct ttccgttgca tcggaatgac 71520 acaaataaat catttggaga agaatagcgt tgttcttgcg gacacaactg tcgtattgaa 71580 ataaattcgg actcatcatt attttctacc ggaggcttca tagattcttc tcttctcttt 71640 tcaacatatt gttcgaaagc cttttgaccc acaggtggga gcggattatt ggtgacaggc 71700 ataacggctg gtttgatttc cggcttctct gcggatgatg tgcgagcgac tcgaagtttt 71760 tcctgagcct ctaaaatcct ttcttggcgg gttttgggtt tagtttcaac cttagagctg 71820 aaatcgcaga ccgtaaccca atcaccctga tcattgcgct tggcaaccag agtcaattta 71880 tagatgatgc cctgcagctt gctttcgcgc atagtgtctg cgaaccagaa agcacaaccc 71940 tgctcgaact tttcagcgaa gatgacgcgc ccgtcttcgt gaatcagaat gacctttgct 72000 ttgttgggcg cgaacatctt attcttttca atgatcgatt cggcgatctt tttggtaata 72060 atcatcacga agtatttcct ttcagttcaa tggaagttaa attttaacct gaaaattatc 72120 tttgatttcc aacgaaatta gtcgctattt cccgacacat agtcagatct ttgatcatct 72180 gtttgctatt gtcggcagcg gactccatca ttggcaaatc caaagcattc tctatttgat 72240 ccacgctgta aagatcaagg cgtttcaact caccttcata atctgataaa aggatggatg 72300 tatctttatc atcagggtga aattgttgat aagtagacaa ccaggccgca cacatattca 72360 atttgctagc cggagttgcc acaacttgga atgatgccaa catagaaaag aataacaaga 72420 atattatgtt tctcatcttt cgttctcctt catcatattg tcacagtcaa tccgtgtttg 72480 cttgagttca cgcgaaagcc ttgggtcgtc tagattgaca gacaaattag tggaaagatc 72540 tttcagtccg ttctgaacac ggtcttcata ataatgatca ttttccacca gccatgctct 72600 caggccaagg gcgcgagtcc gccattcctt tttcagtctt cgatcagatt cttgatcagc 72660 gctgtattca aatactcgaa tacattggtt tccatcattg atgagatcca gctgacgtcg 72720 gccaacctgc acaccttttt gtaatgctgg agaaggaaga gaacggcact gtcttacggt 72780 cattcgtcct tgtgtaccca tacgaccagc cataataaga tcgctcgcct ccatgcctcc 72840 tcggttaaat tcttcgtcgt tcatatatcc tttcaggttg aacgcgcctt gcttatatcg 72900 attaaactca ataccagcat ttacaacggc atctgtgaca ttacctgtgg cccagagttc 72960 agcaaaattt tctatggaac cagttttgtc tatagccacg gcttgggaga acccagcaca 73020 gtaggaaaga tcagaccaca gtttttcacc tgtagaattc agcttggcgg tggcaggaag 73080 tgccagacca gccagcacaa ccgcgatgat taaacgtttc atggtgattc tccttatttc 73140 attggataaa atgatagggc tgtcaccatg ttgagtaaag ggtttcaata aactatcgta 73200 ttcagatcag tatcgactat cactgaccgt tctgtatcgc acaccctgaa attgtttggc 73260 gagttttacg aattccatcg ctggcaaatc aactttgtag accttcatgc gctgtttgcc 73320 gtccatgttc aacgcagcga caaatcggtg agatccgtca acaacgtaat tgtcagaaga 73380 cacccaaact cgacccatag gtttcttatt tcggatttgc ttcataatct tccagacctt 73440 catcttgttg atttcgttct gggtaagacg aagcattttg atgggcactt gcgcagcatc 73500 tatagacacg ccgttgtctt caagatattt gtgaaaatct tcttgtttgt cggcatcgat 73560 ttgcggcata gaagaacgag aaagcccgag gttcccaaca ggaatcctca ggccatttat 73620 gatattcatc cagtcaataa aggatgtaag gaacatgaca cacctcggga tatagggtta 73680 tcccttagtt agttcatcca cctatctttt cttctcgatt cttgtcgttc cctccgctta 73740 tgttcaaacc ggaataacag atagaagaaa ttaccaccca atacgaagat gactccgatt 73800 atcaccagga taccctttac aatttcccaa attaattcat tatccaaagt tacacctcat 73860 ctttattaat tccatcgatt aagacacgag cggaatcaaa atcttccccg ctagtattca 73920 gcatcttagt caaatcatcg atttcgtgaa ctggaccaag atcagattct cgcaaaatga 73980 aacccagaat cccattcaac gcggaagtga tatctccctt gtcgatatca tttttgatca 74040 ccataagttt tacaacagaa ttagtctgac gggaatccag atttaatttg tttgacacca 74100 tgatgttcaa tttgttacgg attattcttt gcataatata gcctcttcaa aattggaatg 74160 tttgtttcat aacgttcacc atgtaggatg aatctactgg tgttctgtta tacgtgatct 74220 tgcccatgcc attcagacgt tcgacaatgc gctcggcatt ctcttctact gcggcctggg 74280 tcggttggta atcgttcaaa tagatcgcga gttcctgtcg attgtcggac gtcacctgat 74340 tgcggagcga aggatagttg acaacatacc cacgagaaat cagttcggca acaagctgat 74400 cgtaacgctc gatcagataa atgagtttgt cgcggaagaa cagcacatga ccttcgttga 74460 gtttgtactg ctttggagcg cccttgagat tacggcgttt tccattcacc acgttaagga 74520 caacaggcgc aagttcttta tactcggcaa ggaggtgttg gtcgcaaaga gattcaacgg 74580 gaataacatt gatgcgagtc atggtatagt tcctgcattt caaatcgacg gagtaatcat 74640 accccgccat aatttataga attaattgat atgcttcaaa agagcgaaaa gaatattcgc 74700 cttggcttta accttaccga cgacacccgt ttcggcatca acctcttcag caacccatac 74760 ttttcctttc ttgctaatga taacatctcg gcgcgaagca tagacttcct tagtcatgta 74820 cacacggcgg aatcctttag cgcggagcaa gccccaattg cggtctattt ctactgccgt 74880 ttctactttc ttgtttgaca tgttataatc aacctattca atttctgacc aaccccacgt 74940 tagccagtta ttgaataata cggcaaatgt ttattcaagt aaagcctttg aaagtaaaaa 75000 tccccaataa ttattgggga tttcatggat tattatttgc agagaacaac gacgagttca 75060 gctaactctc cgagggtagg atcatctcca tgtttaccca cccactcgtc actaatttct 75120 acatcgtact cttcttcgat ttccatgacc agctcaatca tgtcaagatc gtcaccgccg 75180 agatcattct taacccgtaa cggcgctaaa gcatcgatgt tgtcgtcgat attatcgaac 75240 ttttctttat ggtcaccgtc gcgccaagtt tccatgttca ggttgtcaca agcgtactga 75300 gccagaacac gcattacttc aacataagtt ggtttgtttg acataagcat atctcaaaat 75360 gaaggcgggt ttccccgcca gttgaattta gattttgact tctttttcag ccagttcggc 75420 agtgacggtg tatttcaccc catcaacttc cacatccata gtggattctt ccaaatccag 75480 gtcggtaaac caaccatggc ctgcaacaat cccataaact accttggaca gcgttttgtt 75540 cagggcgcgg acttcgttga tagctgcttt tgctgcgtct ccgatccaac tttcgatcag 75600 ctttttctga gtctcttccg gtacgctggt gatcatcggt gatttaacga atgcattgta 75660 ttcagccagg gcattagcga tcagctgatc agcgacattc agttttttac cgtccgtctg 75720 ttttttgata acagacgcga tgctcggcag tgaagatgcg cctttgattt tcacattcaa 75780 ttcacgactc atatagacat cggttgattc tacagaagaa gtcttcggtg aaaatccata 75840 gtcgcgaatg ccgtttgctg acaggaaatc agccgcttct ttgccatatt ttgaagccag 75900 accagtagcg ttgcctttac caaccagttc atcacggtag aatttcagaa ctttctgttt 75960 tgccttcaat gcttcacggc gcacattgtc tgcaaagaat tcagcagcac tgatattctt 76020 tgtcatggcg cggttaacca ttgggacact ttccagattt acaatgaaga cttccggccc 76080 accaaacaca tgaacaccca tggcagtcaa atcctgtgcc accttagccc gaacaatcgg 76140 agaatctgca gtgataggca ttgttttcag gttgatgata ccatccttga caatggtgta 76200 attgcgataa cgccaggttc ccagctcttc aggaagttca tatttcttct gtacaaactc 76260 aggcacaaca accgttccgt gttgaactgt ctgcacactg atgttaggac gttctgaatt 76320 atagaccaaa ttgctgatcg ggacaatccc tttatcatct gctggattga attcgggggt 76380 ccaatcttcg tgctcggcca gtttgagcgc cagggcttta cgctcttctt tagaagtcgc 76440 attcgcaatc tcttcggcca acttgtcttc ggtgtcatca actttctgta cagtaccgcg 76500 cccaatgctc ttgtaagaga atagcggatg cttggtgacg atagagacat ctgcttcagc 76560 cagatacgtc agaacatcaa caatggtggt ggcgtcttca gccggaacca tattataatc 76620 gatgccatca actcctcgca gagattcgtc tacgatagcc tgagtcagat cgactttgat 76680 gttggaatag tcctgcttgg tgaaacagtt gctgtattgt ttgatgaagc ggacgtcacc 76740 cgttttcttc agcgcagccc aaaccaaatc tgcgtccatg gtatacacgc cgtaaaatgc 76800 cagcacgtat gccgcttgga tgtctgccag attatccagc tggtcgatca tgttggggtt 76860 tacaacccac agctgagaaa cgctttcagg gatgctgacg tggccaatag ggtgctcttc 76920 atcaggatgc acagctaaaa cagtcgccac gccattttca acataaatgg catgggtata 76980 aaccagagga acatcgacta caactttcgg tgaagaagtt ttcagcacgt tttccaattc 77040 ggtctgatat tcattctgtc cttcggcgaa tacgtgggtc gcaccagaac gttctgccat 77100 tagccccagc agttcgcgat tacaatacca accgtattcg atgaaggtaa tgttatcaaa 77160 cgctttgggc agtacttcag cggcatccag gatttcatta gaacgccagc agttgtcata 77220 cccatcggtc atgaatgcca ggttgttaac ataaccaggt ttattcaggc taatggcagt 77280 ttccgcagcc aatttcagcg gctcaacaaa accagtacaa ccagaaggct tcaggaaacg 77340 gtcaattaga ttattgatct cactgagatc agttgcactg ttaatctgac gtccggcaaa 77400 taccgttccg aaatcaccgc gagatgaaaa gtaaaggatg ctcacagtat cttccggttt 77460 caccagggaa ggcaggttct ccttcagatg cttacggact tctggaagtg aacgatacat 77520 ggaaccggag atatccacaa cgattacatg gttagacggc gcgacggtcg caaccgcatt 77580 cttaaatgtt aatgattcaa tcatcgtttt gacctttttg ggctttggag tgtttggagt 77640 tcgcgtcggc gttctccagc atagtttcaa tgaaatcccg gttgttttcc atttgggcga 77700 ccagaacatc actgggacgg aatgaattgt caagacaatc aagtccggcg cgttttaatt 77760 tgttgtcggt catcaggctc tcgtgagtta tatttcccaa ctatttcaac atgggactat 77820 tatattacga caggcggtat tgatgccaat taatataata aaaatgcccg attgaatata 77880 accgggcatt atattattga caggttgaaa tattattcag agcttattta aaggagtcta 77940 caatggattt gaaaatataa tctttggagc gttgttgtac cgggagttct ccatacggaa 78000 ccatgcaagg gtgttgcttg gtctgagggt ctttgactgg gccatacacc catccctcag 78060 cctccttctc cgccatccag ctctcatgcg attcgctggg cttacgatca ccagtgagat 78120 ggaagataac acctttgcaa gcgctctcac gctgccaggc cggagattgt tcccaaggca 78180 gttgagagtc gtcaccaaca gacttgcagt atgcgcggtt ggcttcatga caaatcttgg 78240 cgatgcgcag aaccaatggc gaataagtga gatcgagttt ggagttggcg cacaggaaat 78300 cactaacagc cttacgagat ttggcgttgt gagagtcaac aacaagttcc atgtcatccg 78360 gcccacaaac gaaagacgcc aagaagcgct cgccattttc cgctctgaac atcacgtcct 78420 gaatcatcac attgaagccg aggtgatagg ccgggcagag ggcgctacgt tcaacagcgt 78480 attgatcgat ccggatctct gccgtttccg tggctttggc caacagatct tgttcaacaa 78540 gcgcccggta cgcctccagc tgccacagct ggtcgaaggt gttattgtag gaaatctctt 78600 tgcccagggc ttcatcgaag ttggccgggt ctatggatgt gctgggcttg gtgccgtgaa 78660 cgacgaagcc gttatccatc ttgaaatgac aagtgatagc ccggtgaccg ccgacttcgc 78720 ggtcttcgta aatcacctca gcgatatgtg acttcaggac ttcaggagtg agtttgatgc 78780 cagtacgagt tgtcatgtgt tatcctatga tatttgttta cagacctcca ctactttacg 78840 gcacatgacg atatcgaaca agccgatatg gcaatcgcgc ttcttgatcc ccagattatg 78900 agccagccag ctgtaagcat cactcctgct cctctgccca cttttccaga tagggtcaaa 78960 cgacctatga gcttcctgct tagcagcacg gagagcggca ttcgccatcc ttcccagagg 79020 ttgtctacca tccccatggg tatggcaacc cacacgagcg tcgcatggcg agcataccca 79080 gaacttcagt ttgtgtagat ctgggcgatg agggtagagt acatcaccac tgacgtattt 79140 ggcaggaagg ccgcagtaat cacagatgac aggtttcata ttctttgtcc aaaagaaacc 79200 ccgcacacgg cggggttgct taggccgagg ccgacagatt atttcaggag tttttccagt 79260 tcttcaacag agagaccttc cagttcctgc tgtttcttac gctggatcag ttccatgatc 79320 gt; acaccgatga tcgctttcac gatatcgaaa cgcagttgta actgagagtc gactgcgctt 79440 ttcacgccga tgaaatcttc ttcatcgctg gcggcttcct tcacctgacg gctgaggtct 79500 ttcgccagtt cgtttagggc attcaggttc agatcccaaa cctgctcaac agacagcaga 79560 cctttgttag agttgaaacg cagttttaaa cgggttgctt gatcaaacat ttcattgttc 79620 cttattacga atttgtggtc aaaatcaatt agaaaatgac ttttacagta cggttaaacg 79680 cgccggacac tttgacgaac acgtggttgc gttgcgtcgt cgagaatccc agaccggaca 79740 gttggttttc attcggctgg actttcattt tactacccaa catttcaaaa accttacgat 79800 gtttatccag ttctggcttc agatattcgt tgtagaaacc acgagtacct tcaggattag 79860 cagacccttc aagaatgaag aacacatgct tgttaccagt ttgctcccca tcccaatggt 79920 ttggtgaatt caggaccagc tgtactttct ggaaggtcgc agtcttgata ccccaaactt 79980 ctttagactt atcaacatta gccagttcgg acttaatgct aacgacttgt ttgtctttaa 80040 cagtcaggat gactgcagtg atacgcccct gatctttcag gccaggatgg ctgaaacgat 80100 gcgttgcgcc tttgtattct acttcgactt caaacccttc gtcgatcttt tcacgttgat 80160 tgtagttgtg gatttcgaaa cggtattcac catcgcgcag cttgctttca tctgtaaaga 80220 tgatattttc caccggagcg cggtttggat caataccatc cataccgttc atatcgatat 80280 ccagatgggc acctgtcata gagcgacgat cacggaagta cacgtgctcc atattgttaa 80340 agaacatatg cagatcgagg tcgtcgttat tgtgccacgc caaggaaacg cgcagatacc 80400 cgtcaacttt accgccagca gcctttacac gttctttaat ggaatcggtc acttcaccgt 80460 tgtaagacca ggagaacccg ttgttccact tgaacaggtt aggcgcatct gggttcgccg 80520 gagcaaccag ggacatcagg ttgctagtat gagaattctc tacaagcact tccattgaat 80580 gcgcttttgg cagaacattg ctcaggaaat catcaatgct gatctcttca actttttcca 80640 gggacttggt cggagttttc acttcggcgg ccagctgtgc aaacggatcc atcgctttct 80700 gagcagccag atctgcgaac agaacgttgt tgattgtcag atcatcgtaa accgcataac 80760 gacgcgccag tgagtcttcc aaacccagag caataacttc tttctgagcg ttttcgatca 80820 tggattttga aaccagcgct gtcggacgtt tgtagttcgc cggagcaact ttggattcaa 80880 acgatttaac agccttttcc agttccacgc cttcgctgat atctgtcagc agagtgccga 80940 taactgtgtt acggatgccg tgtggaacat gattgtttga acggtatcca gtatgccatg 81000 cccacagaga acgggctgat tcggggattt gttcatatgc ctttttggtt tcaacaaatc 81060 ccttcactgc tgctttgtgt tctgcgccgc gatacagaga attctggtca atcagttcca 81120 gaacgatttc agctgattcc agagtaattt cacgcagacc gcgttcaaac aattcaatag 81180 cctggcggat ttcacctttt ttcgaagcga ttgcgtccgg acgcagaaca tagctaccaa 81240 gtaattgggt atggaaatga ttgtaagtac ggattttgcc atcttcacca gattcgtgat 81300 tgtgagacag gccgacttta gcagaatcgt taaaataaac atcgacgatt gcgtgttgtt 81360 gacatacgcg gaaagagccg cagccaccac gtcatattca ttacccagat caatgttgtc 81420 ccagatagaa attacgttca gttctgaatc gatggtgaca acaccgccga tgttacggat 81480 gaattgttta cagcaggtgc aatcgtgttc agtacgttcg cggtacagcg ggttagtacc 81540 agcagggaaa gatgccagat acagatccca aagagcatct ttatcgatat tggtcatgaa 81600 cagaccagtt gcggacatcg ccagcacgtt gttattaact gccgttgcga agggtttgaa 81660 gt; cgttaaagtg aggtcaatat atacgttgaa aaagttattg aagaacgaag taacgcgatt 81780 ctttattcag gtttcttcaa acgatctaat aaattgaccg atccgcgatt gaggacaatt 81840 tcatcgcatc gatttttgta tctcccgcct ccatcataac cgaccttgcc gcgtggcttt 81900 tcccctctct cgatagcctc aacacagcgg gtgtacttgc tcaattcaca gaacatgttc 81960 tccagctgca tgacgttcat gcactgatct tccggcgctt cggctgacca gaactgctct 82020 tggacataac catactgagc aaacaattga tactgatgat cacgaaccca gaatatgcat 82080 tcttcatgag tcatgccgtc cttatccagg aacatcaggt caatacccgc acggcaacct 82140 ggaccagcaa tagtgaaatg attctcactg aatggatact cagggatgta tgtgaagtcc 82200 acccagatct gatatgccag gaatggccca agcccttcaa tgtcgtcata catgcgctgg 82260 taaactttca gcggagagtc aagacgtaaa agatcattga agtaatcggg gtacttgttg 82320 acgaatgcct tcaaagagcg gatgacacgc attggcatgt acggctccca accctcaatc 82380 gtgtactccc caggattctc ttcaaccagc ttcttggcga ccttgtaatc caattcatcc 82440 acgacaccct ggccaacacg gtgtacctta accatcatcc caccgaagcg ctgctccttg 82500 tggttgacaa caagttcggg gaacgccaga cattgtttta gaccgcctgt gttgaatgca 82560 ttggtgaaga tcttaccacc ttcagattca aacttctgaa gacgggcgcg ggtctcgtcc 82620 aggttgattt tagcaaagtc tgaaatcgtc atagcgccct cgagcgccac cttgatcggg 82680 tcccagagat tgaacatgcg gaacagaaca cagttgaaca ttttgtcggc catgctcaga 82740 gcgtcgttct tgacgatatt attgatcagg ttaagagact gcctgtcgtg ctctctccgg 82800 acgttacaga acttgacctg ccgtagtatg ggattatccg tccaaggagc aggaagacgc 82860 tggacgtcct ttctcacgtg gatcttataa cgctcgctca tccattcgta tgcgagttgt 82920 ttatggaatg ggcttaacat gggatgtgca gatttaattt tagcttcccg aacaccgcaa 82980 tatgggatgt catatggttt atctttcatg gtatcctctc tagaatacaa aacagaggcc 83040 attatagcct ctgttgttta gtgaataacg gattatatta atcgaagcga gagaggtgtg 83100 tcacagtgtt ttgaacaggt gcgcacgcgt atacacgaac attagctccc cacaccccac 83160 acagcttagg catattggta tcgttaatga tatacgctgg cacataactt tcaatttggc 83220 cgttaacatc tacgggtcga gaagattttt caactgccat agaaagaatt acttccaacg 83280 tttttggaga taccaacgcc acgccgttca gatcatcaac aaatacctgt ccttcttcaa 83340 ttgccatgct ggcaacgatg tcattgatct gacgggaagg ggtattcgtc agcatatcag 83400 agaaatcagg ctctttgaac acagccatgt ttttcaggaa ttttcctttc ggatattctt 83460 tgccattcca catcacagtc tcattcactt tgatgcatgc ctgagggaat tcaccttcaa 83520 cgcgtaactg gccatctggg aaaccgcgtg aataataata ttccagtgcc ggaccgactt 83580 catcttctga gcgaataaat ttgctcatgt tggaggcata aacacgctgc aagcactcat 83640 cgccgttgaa accagcaatg tgtgccacgc cgtcattgac tgttgtgatg tcgccctgag 83700 cgtccaaaat ctggcgcata atgtctttga tgtcgacaac agcaggttct ttcaggactc 83760 gcggagatgc agtgaactca attttcacct cgtggtcgaa ataagccgct tccagtaatt 83820 cgcgggtctc ttccagaacc agtttggcct gattgcgaat tttaccgaag tcaggggctg 83880 taatatctcc agccgcatta ccaaaagcca aattcaatct cacgttttta ttaaatgtag 83940 ttgtcataat atagcgactc cagttattcg ctttttgccc gacttgggcg aatagtgtat 84000 tttggaacca atttccactc agaaacttgg tcatgtttta caactttgat ccgagacatg 84060 tcagccactt cggttatttg ttccggatgc aagatcttaa ccatattcca ttgctccaga 84120 agccgtataa tccgattcat acgcaggaca tcttcacgcg taaagccgtt gtagtgccca 84180 tctagcatga acaaatgctt gaaatgcacg atgtgatatc tgccaaattt atgcaggata 84240 tggcacgttt gatacaaggt gttaggctct tgacgagtgt taacccctat ccgactcagc 84300 gtttccttga tacccaggaa aatccctggt ttgtcttggt tcaattgaac ttcaaccata 84360 cagtcaacaa tgctggcctc atcgttgaca gctgaaagtt ttaagatgtc cagcgtatta 84420 cgcgccatga ctcatacccc tttaacaatt atttgaatta cttagccttg cgcggtttgg 84480 ctttttcgtt gctgttggaa cgttcgacct tcgccttgat ttcagccagg acttctttcg 84540 gcaggaatcg aacatattct gaagcctttt caggactgat gtaataatac tcagaaatca 84600 atttcacatc aggatccata gctcccttct tagaccactt gtcatagcga cgttttgccg 84660 gaatgctatg aaacgccagg ttccattgca tccaaggagt aatggcatgg aagcggttca 84720 tttgttcagc aaccacaagc gtgtctttac tctgagcaag gccgcgccga gtcatgaaag 84780 gatcaaaagc ctttctgatt tcggggtctt cggtcaacaa cagattctct ttggtgctat 84840 tcaacgcacc gaggtaatcg aacagtgacg gagcggccat aatattactt ccatttgatg 84900 ttgagcatga cgttagtcaa gaagtaaacg ccgtgtaacc agacgtcgcc gacggaacga 84960 tgttcgatct gagactgacc acagacgcat accagatcag ggattgactc gttttgaatc 85020 aaaggagtct tttccttgtt ctggggaacg cagaaatgga agaaacggga ataaaaatct 85080 tcagtgatgt agttttggtt gtcggtcacc cactgcttca tcccagccca atcattggtt 85140 tttaggaaat ccaccaacgc ttggaattcc cctgctttaa cctgtgccag agcgcgttca 85200 tcgattttac caaacgtggt ggcattatcc tgaagagttc ccataatttt gcgattatct 85260 gggaaatatg atttcacaat ggaagcaatt acaccagctt catacggaat gccttcctct 85320 gtcaggatag ttgcgcaacg acgcatgaat tgaagtttaa cttcatctgc ttccttttca 85380 gaccagataa aatcaatttc gcgacagcgg gaacgcagag gttcgttaac gcgctgtttc 85440 gcattagtcg tcaggatgaa ggagcagttt ttggagactt tctctacgat gcctttcagg 85500 gattcctgcg ccgccatgga aagtcgctca acttcatcga ggataacgac tttgcggcca 85560 ccgaaaacac tgacgccagt tgcgtattga ataacacggt cacggatgac atcaatgctg 85620 ttatccagtg acgcattgat catcaacggt ttgatacaac cgatttcgtt gcaaacagcc 85680 agagcagaag tagtcttgcc cgtaccaggc tgaggggaat agaacagcat tgaggggatg 85740 tttccattgc ctgatgtaac atagccatgg atttttgcac ggacgtctga agggaggacg 85800 atctcatcca gattgtcagg gcgatatttg ttttcccacg catattgatc tgtgacgata 85860 gtgatgttag acattgcagc ctctttagat aaaacgtttc aaagggcggg gaaacccccg 85920 ccaccgataa taaagcgccg aatcgttatt gattaatcca gctgcatgcc gacgtaatag 85980 ttgatggtgc cgtctgcgga ttggaagtta accagttgca tttcggcaca ggcgcggatc 86040 acgtagttgc cttcgatcat tttcaggttg accacatcaa caggcatagc aaaatcaccc 86100 agagttgttt cacccaactc aacagtgtaa tcgttggaat tgtcgatagt agtggtcgtg 86160 cccaccagac gagttttacc gccgctggca accagacgta cagttttgtg gcccagagta 86220 gaacaggcgc gggtcagctc tttcattttt tcaggagtga ctgttgcttc aaattctaca 86280 gacggaagat cgatgctgtc tgccggaacg acagtcagtt ctttagcgga acgccagaat 86340 tgcagttggg agttttcacc tttcagcaaa atgtggtctt ccgacatttc aattttaccg 86400 cctttaaaac tcggcagacg ctggattgcc agcaatttgg tcagatccag aatcgggaat 86460 tcgaacggga agtcttcgtc gatgtcggca atagcgataa ctgtactgga atcgttaaca 86520 gtgcgcaact ttttaccagg tgccaaaacg atagaggggc agatggtttc aaagttagcc 86580 agcagttgta aagtgcgttc ggagagagtg atctcttgca ttagttgtat cctcaaaata 86640 tagtggggtt caagtcatat ttgacgcaaa ttagtatcgc gtgtttgtag ttatagaaca 86700 agtgataaat tgccctacgc gcgataaata aatgcctgac ggcatttata atattctgtt 86760 ttaataaaac ctttctttat cagtctactc gcttcgctcg tgataatact cgttgctcgc 86820 aaagctcaca actcgtatat tacgcacgga ttgttcaaca agaaagcgat ttttattcaa 86880 caattaaaat attttatttg gtctaaacag agcatgacat tattatgtag ccaagtttgc 86940 taacacgcga gaaatacata tgaagcaatt tgttggttta tacgcagtag gggaagacca 87000 agaagcaatt ctttccatat cagaacaacg ttcgtcatta aaaggcgttt atttacaaag 87060 ccttttctgt acatcggggt ttgttgtgac accgatgatg gtgataccat tactcccaaa 87120 taacaaaggt ctgtatgttg gcattattca acaaggccag gcgcgggaag tgaaagttgt 87180 tccattgctg gcatctaatg aagaattgtt ttctcagatt cttgagccga aagtgctaca 87240 acaatgtatt ggcacgatcg actgtttatt tggttccaac aaagaaggcg aggcaacccc 87300 cgcctatgtg aatcaagata tttgaaatgg ttagagcgcc acttttttca ttttaacagg 87360 gtggcgctcc ataagataaa atttatatct ctcatgagaa tgcctgagag catggttgta 87420 ggaaccgttg tagcgcaggt tgtctaccag gtcccagatt cgcgcaacat ccttagagga 87480 atgamggcgc atcaaacgcc ccaatgtctg tataacacgg atataagatt tgctgggatg 87540 ggccaatatc agatgatgga gttttttgat agatacgccc tgttgcatag taccatatga 87600 tgccaacagt gttatatctt ccccttcttc catagcagcc tgaatctgtt tacgaacttc 87660 tgtcttgact tccccgttga tgacgaatac gtttttcttg actgccgata gcatttcata 87720 aaccaacatc atgtgtgcat cgatacgttc gaacatgacc gccacgttcc ctttcaaaga 87780 cagagccatt cgggctatca attcattgcg gcgttcgtta gcaatgagaa attctatttc 87840 cttttgatac tcagcaccgt gcatttcaat acagtctgcc ataggatgta tgacttcaat 87900 catattaaca ttgatgtctg ccgcatatcc tagatcgatt aaatcgcgcg ctgtaataat 87960 tttatgatat gcgccaaagt gagcaacgac ttgtaaccct gcgacctttg tattcgccag 88020 ggttccggtt actcccaaac gttgatcagc gttaatacag ttgttcaaga tgtaagacaa 88080 tttatctgat tttgatgtat gtacttcgtc gacgacgata tctccaaatt gatggaacca 88140 ctctttgggt tggttctgga taccttgcca agttgaaata actatgggtt tgaaaatctc 88200 tttcgttgcc ccttcgtata ttgtctggac attcatcaat ggcttccatt ctgtcccgtg 88260 gctatattct tcgaagttgt catacaactg agtcaccaaa tgaatggatg gtacaacgat 88320 taacgtcctc agattacttt cgagggcatc tctgcgttgc ctgtagtaac gcgccatgat 88380 gtacaaaata aaggatttac cagcactcgt ggcagcttcg aggacacatc tactttgccg 88440 tattgctgtg gcaatagaat caaattgata ttcgcggaca atcgcttttt gatattgttt 88500 gttttcgtct cggtacactg cattcaatgt atcgatgaac gcatgaattt cttcatccgg 88560 aatatcttga atatatttta aggccggatc taatttgatg gtgtaaccgt tcatcttaca 88620 gaatttgaac acctcaaata acaggccgat gtcgataagc ccagaactct ttgtgaacag 88680 ccgcactacg ccgtcccatt tactgaacgg attcggttgg aaattaggat cttcaaattt 88740 gaagtaatcg ttgagttctt cacggatata atcctcggca aggatccgca ttctaacttc 88800 gttcactttg actatttgga tctcagacat cactaatttc ccccaatatt atggagtatt 88860 tagcgatccg cccagattcc tttctgttct ttatccattt tgtgatacag acggacacgg 88920 tcaaacattt tagaaataac gtctttgcga tcgaattcga ttatggtggg aacaagggca 88980 ttttcgttgg atataatatt gattaaacgc tctatcttga cattaaacat ttgttgaaac 89040 atagacgagt atagacacaa ttgaatacta taatcttcta tcatgcttcg agtttttagg 89100 gtgttggatg ttttgaaatc gattatgctt ggaattcctt cgtaaacccc gatgaggtca 89160 acacgaccag caagacccag gacttcgcta tataatggaa tctcttgtgc atatatcttg 89220 ctcattttgt taaggtaggg gaaaacctgt ttgaacataa acacgtattc ccctgcagct 89280 tccagaactt ctttcattgg tctgtttttg agatacaact cacaagccaa atgaagtttt 89340 tccccacggt ctgcgcaacg atgtgtttct atatcagcag cttcatgccc caacttgtcc 89400 cgccaggctt ctaaccatgt gtggtcacca gtacgcccta acatggtcgt cactgaagtc 89460 agtttgactc cagtgggaga aacatagtga cgaccatttt cggtagttac gcaagtcagt 89520 tccttaaacg gcaaggaata ttgctgaaat gtatgatgac gattttcaaa gtcattaagt 89580 ttgcgcaaag cctgtagaga aaccattaca tcccatccaa atattttcgc caatcaatag 89640 cattcttcac ttcatatccg agtttgttca aacgatctaa gcaactttcg atgaacttga 89700 ctttggcttt ctgctcttga agcatgctag acaattcgat ataatcatca tctgctttta 89760 cccatacgtc tatatcagat ttcaggggtc gaacttttaa tgggcgttca acataaacgt 89820 tgggcggcaa ttcccctgca taaaatcggc gtaaatagag atctatttgg cggaatttgc 89880 cagttagata ctccagatat cttccttcac gaatataatg gcgttgcaca gtcatccacg 89940 aacgaccaat tttcaatgac atttggtcta agttcatgtc ttcaggattt accgaaataa 90000 gaggttccaa ttctgccatt atatcttcgg ttttcatcgt ttcaagtttt gtttcgctca 90060 tgatttattc cctgctgttt caactctctg tattataact tattgtttat caatttcgcg 90120 ggtgacgcga gtcggagtca gtttcaaata tttgaacgtg acagtcgtga ccagttgggg 90180 aaccgcagca tccacatcca ccaatacgtt gtccaaagct gtgggacggg cttcttccaa 90240 caacaattgt agaccaacag gtcgattcat gttatcaaga aggtcgatgg tgatgtcgcg 90300 gctgacagct aaatcagatc cagcattgga cgcaatccaa ttgtaaatct gttcccagtt 90360 gtaccaactc tcatcgataa cgaacgtaaa tacgatgggg tcatacgtga gacgttctga 90420 aggtatggag ttgagcacat cgccagggga tggtccctcg ataccttcag aatacactcc 90480 aggaatactg aagtcatgta ttgaacgagt gagcaatatt aggtctccga tagttaagcg 90540 ccatttatcg gaagccgcga aattaggatt ttcgtttttg aattgtacac ctgtcatgtt 90600 agcacctttg ctgtggagaa cgttttagtg ttcctgatac gcggattcag aaaatggatc 90660 atgacgatga caatggtgct tgcactcaca agttgccgta tctttgtcac gtccgtcatt 90720 tctgtaaccg acctctggga tcctgaaatc agaaccatac ctgttaacat ctcagccgac 90780 attgataaat gcaataaaaa tattctggat caagtagtat ctgattttca gaatttccag 90840 actcttcaag ctgttggttg ttttgatgat aacaaccagt cactgagacc atactggaaa 90900 accacgattc ccctattgag gaaaggtgac gaaggaaaga tcccatatct atccgcaagt 90960 atttattact ctcagaataa tagcatcata gcgactttca acccttcttt ctttgacaaa 91020 ctcagaagga atactcaagc aagggacgta gaaatcacca gagacgttgc aatatcattt 91080 cagatagtta ataacaccaa atctccgata cgaattgcca ctcagggtgt tttcgttaat 91140 ggatctgctg tgggtaatga aatgaacatc tatgaaataa gaccaggcgg taaagtatgg 91200 attcgaatga gtgatgttgg ggtgaactcc ctggtgatgg aaggtatcga accagtggga 91260 gttctccccg ctagacattg attatttcag ggactctttt aattctggag tccctatttt 91320 atcaataacg cctccagcac agagatcttt agcccattct ccaagaacat tcgcaaaaga 91380 gaagtttaga cattctttga tcatactttc aatatgagca agttctgcag ctatcccatc 91440 ggtgatatcg tttataactc cattgacggc ggttattgcc tcattgatat gtcctgttac 91500 ttcagcagcc aattgctgta gttttgccat cccttctgag gcaccttcca taatcatgtc 91560 atacaattcc gatatcttgt ttgttacggt ctgtagagca ccttccatag cattcagcca 91620 ttggcgtcct aaatcctgaa caacaccaaa agccttgttg atcaaatcac aattgtttgg 91680 ctctcgtgat atacccttca gacctgattt gtatgacacg gaagtaccga tgcgagaata 91740 cgcgtcattg atactttggt cgccatatgt gttcagtgtc gttatccccg tgttggcggt 91800 gctatacatg gtggtggctg ctgtgagttt ttctggtgtt agtccaccag caaccatagc 91860 cgcctgcatc tccggagtcg cgttggcagt tatcaatggt atattggtac taccactggt 91920 gattaaatcc tgtgagggac cggagaggga cggaagcggg ttgctaaatg cgttaccaga 91980 ggaaaggaca tcgtagattt gtgcgttcat aaataccccc aattttgggg gtatttataa 92040 tcacggaaga tgatagataa aattctcgca gaactttttg gtgtatttct ttagaaatat 92100 aaatttaggt tcgcgtggtg tatctttcag atcatttagt gtgatataac tgattcgcgc 92160 cagaaagtac atggtaaaag cgacacaaag aatcaaaatt aattgcagca tagctaactc 92220 catatgggtg tgaaggcaaa catatttata acaatcgttt ggttttgggt ttgcccatga 92280 gagtgatatt gacattgaca cctgcttttt tcatgcgggt aatcatgtct tgcgtcccag 92340 tagacgaacc atcccataac gcaattccaa agacctcaag acctttttgt ttggccaggg 92400 tcatagcttt gtctaacata tctttgttac gttggtttcc tgcacctttc ccatatatcg 92460 tgtgataatc cttagggatc cccattggcg taacatggac ataattgatt tcacaccaat 92520 cacgagatat caagtccaca ccaaccgctt caccttctat aaaagtttcg atctcgtggg 92580 gatctaacag ttcatccagt ttggcgaaga ttttatcccg ctcggttatt gagcgggaac 92640 ctgtaatgag cacgacatat ttcttcatag aactcacagc gccccaagat tgctgatgac 92700 gtacaggctg cacaagggag tccctgatga acgaggttct atgctcattc ccgagaggcg 92760 gatcagttcc agcaaaccgt cggtggtctg atacgcacga gtcgaaccgt ttggacgata 92820 tagctccaac tcggttcgcc cttcctttaa tgcgttacgg atgcgtgtga atacgctgtg 92880 ggcttgatat ttttgacgta gaatatctaa acgggtgatg agatttcggc tgcggctgcg 92940 acgtcccgtt gacgaaacaa ctaatttcat ttctggtgtt ttacaagcca tgttatagtc 93000 ctctatttgt aggggttggg tatgatttta acatacccgt tcaaatgttt tagaacaaat 93060 tacagatctt ggcactgatc gcaatattcg tcgtatgtga atgtctcatc acacaggccg 93120 tcacgcatca tatcggcctt ggcttcgcca aacattttca gggtgataac gttgccgtct 93180 aaatctttac gaagttcgtt cggcttggtt tctatgaagt cgaacaccac aaagaaccct 93240 tcggtgacat atttgatggt tttgttgctc agcttacgaa tgccaccgtt ctttttgaag 93300 atagaggtgc ggaggttttc gaattcggcc agattgtcat cgtgattctt gatggcgttc 93360 agcattgcgt caaggtcgat ttcaggacga agcattttga cctgatcttc gcggtcataa 93420 gaagtgaaag attctatgtt ggtgatgccc agagcgtttt taacaaacgc gtcaaatttg 93480 gtgaaattgt tgaatgccca gacggagatt tttacggttg tcatgactga tactcctgtt 93540 gtaagaaagt tatatcgtac aacaggaatt gttattgaac tattcgcgta ttaaatcgtt 93600 acgataaaca atcacgtatt ttgagaaaca tatttcagat atgcgtattt gtaaccttcc 93660 tcggtgagta cacacagatg tgtatctcga ccttttggta cgtttttaac atcaactcgt 93720 ttacaaaacc ccagggaggc caattcggct tctccagatt tagcaggtat ttccccagct 93780 tcacgaggtc caaaccagaa aagaacgaat agagtatcga ctgcaccgcc agataattga 93840 tgagacattt taacctcctt tgataaatga ggctttatta tcttacatat ccctataaag 93900 aaaaaccccg ccgaagcggg gtttgttatc aaaacctgtc gattagaaca gagatttgat 93960 caagcccttc ctgaagtaag ggttgctgtc ttgagcaata ccgtcagcag tcacgtaaac 94020 ctgcgggtct tggttagccg gaatctgtac gaacgggtta gcacagatgc cgtaacgggt 94080 tttgaacgcc atacgcggag cgaaggtggt ttcaccctgg gtgcggtaca tttccagcgg 94140 cacatacggc gcgaagaaga taccggcatc cagcgcagtt gcgcctttgt atgccagggt 94200 gatatattct gctacagcat acgggtcaac atagacgcgc ataccgttgg acagaacacc 94260 agcgaatgtc tggccagtcg ggtcaacagc cagtttagtg ttttcctgca gaaccggagc 94320 atagtccagc atgccagaca tcgccagagc ggatgccacg ttcggagaac acagaacacg 94380 gttgccttta ccacgacggg tgtcaacacc gataccgttc gcttcaactt ccagcatgaa 94440 agtcaggaac ttccattttt ccagcgccca acgaccggag atgtcctgcg cgatatcaac 94500 aacaccgttg gtgccgaatt ttttgaagcg aacagcactg aagttcatgg tacggatgaa 94560 ttcacggttc atttccgcct gaatttcagt taccatcacg tcagakhga tattatccac 94620 gtcttcgccg tgaatcgcca tcatgtcctg acgcagttcg tggctgtaat cagcgtacaga 94680 gccgcgagac ttggcagtaa cggtcgcttt ctgaacagtg ataccaacac gcgcccaagg 94740 gttggtggta gtacccagca gttcagcgtc acttgacggc atacctttac cgatagtggt 94800 ccgccagag ccagaacctt cgatttcagc ctgactaaag ccagacgggt cgccagcctg 94860 tacagtacca tcaccggaat agccggaatc ggcttcctgc atgaacagtt ctttacgaga 94920 ctgtgcggtg ttggaactgt cgccaacgcc ctggcgagcg cgcagtgcaa agatctgacc 94980 gtcaggacca gacagcggct gaacaccgaa gaagtccatc gcgatgttga tcggcgccag 95040 acgttttgcc atgtcgatca gaactggctg ccatttaccg acagtgctgt tcacagaacc 95100 aggtgcgtca gattcgccca ggttttttgc gttccattca gcctggttct gcatcagacg 95160 gatggttacg ttttcggcag acagaggttg aatagcttca gattcttttt ggagaactgg 95220 cagccactgt ttgcgcattt cttcggttac aagtttctta gtcatgatgc tcgttcctta 95280 cattgatatt cagttaagtt gaaattactt agtagttcaa aatcaagccc cctttcgagg 95340 gctgtggctg ctaaaattag ccgttcagca aagcactgat ctggcgacgg acggcttcgt 95400 tgacttcttt gccaacttcg tctttgtcat catcgtcatc gtcatcatcg tcgtcttcac 95460 cttctttctt cggtttttta ccttctttga tgtctttttc agacttgtcg ccatccggct 95520 tgcctttttc attgtctttg ccgactttat cagagaagtc atctttgcct tctaccaggt 95580 tacggaaggt gcgcacacgg gattcaaatt cagactcagt ctggaattca ataccttcca 95640 gcaggttgac aacagtgtct ttcttggtgt caaccatacc ttcacaaata cgatcaatga 95700 catcattgcg ctggcgtttg gtttcacttt ctttgagctg agccaattca gtattggcaa 95760 tgctggcgcg tttctctgct tcagccaggc ggttggtgag agctgcaatc tgaccgtctg 95820 ggtcagtggc gaaactaaca cctgcttctt tcagaacatt agagaaacca gtgaggaagc 95880 gttcagcagc ttcggttttg atctgagcgt caatagctgg ggcatttttg ttagcccatt 95940 cttcaacaac cgcgttgagg aacgaatcaa ctttttccgc caactgaaga gtgaaatttt 96000 ctttaaggtc tgcgacttct ttctggtgag cttctaccag agtcaggcgc tcaacgttac 96060 cagccgcttc agtttcttga atagcttgca gacgggcggc ttcaacttta gattccagca 96120 gaccagatac tttgtccaag aaatcggtgc tgaggccatt aacgccttca aacagttttt 96180 gcaattcagg tttcatgata gtttccttct gaacgatttt tcagtattta gtgagctgaa 96240 attcagccca gatgattcaa tgctgcatca aggcggcgca ggaaatcgtc ttcaacctgg 96300 atattggttt tcaccaactg gtctacaact ttccctttaa catcacgagg catccaaata 96360 cccgaagcct catcaagctg ccattcaaca gattcactca cagccttaac ataacaaact 96420 tgtccagaag gcggtcgac tgcatcaaca gcggtgagca taaagccagg ctgaacgtca 96480 tcataaccgt ttactgactt ggtctcaccc aggccacgtg tagacacggc cagattgaag 96540 tctgcttcag ccaatgcacg tatgatttgg ccttttggtg tatttaaaat tcgcgcccga 96600 ccgatggcat tagtgccttc ccagcgaagg gattcggttt tgagcgctgc ttccaccaga 96660 ttagggaaag gatagtcagg atgtgtgact tcaccgattg cgcgacgatc ttggatatac 96720 tctttgtcgt atgcttcgac agcaggaata cccactttct gcagatcata gttacgcccg 96780 ttacggttga cttggttaca catcacaaac ggaccttcga tgaacatggc cttcccacca 96840 gttgaggttg tggcctcacc gatttgaaga tccttcccta tcgctgtgat ctcacgcaac 96900 agtttcatca taaactcctt acttgttctt actcagtccc atcattttgc ggaacttcat 96960 agcctttttc ttgcggcgct cgattttacg ttgatagccc attcccatac gctttttaga 97020 gcggagggct ttgcggttgc cgatcttgcg aacacgacgt tcgctggcat ccatgacttc 97080 acaacgtgaa ccatcagccg acaatttgaa cccaggggca catttcaagc ggcggcggcg 97140 tttaccacga gcgttcactt tatcgatgac tcgctgctcg tccatacgag aggccaggaa 97200 atcagcgaac gtggcgatct ctgtgatttc catcatgcat ctccttactg gccgttgttg 97260 tttgaattca tatcagctgc gatagaatcc agaacatatg ctgtgccttg gtttaatagt 97320 tcttgactac gtgcatcaag ttccatgttg cattctgcaa cagcagtttc agtgtcaccg 97380 tcaattactg cacgaacgat atcaattgcg ctcatgattt tgatctccga attaattttc 97440 tatatttagt tgaactttaa atactatcgt ctgttgaacc ggagaatggg atagtctcag 97500 gtttaaactt caacggacta acatctgaac cgctataatt gccagtttca tctgcttgaa 97560 ccttcggata gagacctttc ttcttctctt ccgcgatctt cgtttgttgt tctttaactt 97620 cttcatcaga catacgcaat acatttctca tgacgtagtc tatggagaaa atggaaccaa 97680 cgaatggctc aacagtgttc aatgaagcca gacgatcatt caagatagcg ttttcttgtt 97740 gttcacgaat gtaactatcg gatgtgaatt caaactttat aaacggtttg atcttctcat 97800 tccaatcctt ttcatccgta acgcctttca aaattaactg gcggcgcaag aattccataa 97860 agaaatggga gtaacggcgt cgtaacccag cacagaactt gctgaagcgc agctcttcct 97920 gtgtaatctc cgcaaggtta gaacccccaa tgttaataga tccttcctct tggaggcggc 97980 tcttagggat cattagagca tcatagagtt tttcacggaa atagttcacg tgatccattt 98040 cgcccaattg attcccaccc ccaacagtcg caatctctgt agcattctga ccttcgcggc 98100 gcggcaacca ataatcctct gcaataccca taagatgggc attacctgtt atcttaccag 98160 tggtgcggtc atatgcgttg cggtttttga atttacccat catcatggtc atgtattctt 98220 cagcagattt cttaccgaga gtaccgacgt caagatagaa tgcgcgtttc tcaggggcgc 98280 gagtgatggc ataaattact gttgcgtctt cagtcgtaac caagttgttc aacgggcgga 98340 ttgcaggatt taaaagccct gggacaatac cgttagccaa tggttcttca ccactatcga 98400 tataaacgat actttcgtca tcaaacacga gttcttgttg tgaaggttgg aagttttgag 98460 aagtacctga ttgaccagtg aattggttcc ggttgtaatt cggattgtaa tagtatttca 98520 gcgttacaga ttcgatcgct tctataccac cttcacgcat tgccttttca acgatgtaca 98580 caggacgaat acaacgagaa tccagcataa ccaatttctt gatcccgcct tttttattcg 98640 tgggatcaac gatgacatga tatgcttgtc gaccgtcaac ataccatttc cggatcttct 98700 gatatgctgt attgtcaaag tccatcaagt gcataacttc tttgaagcat tcggtgatag 98760 attctttaac agaatcagat atcccttcaa ctttgtcaag gtttactgtc actggagttt 98820 catcttcctc acaggtgaca acatcattga caataatgtc caccgctttg cgaatttcag 98880 gctgttgagc catggactga tattcttcca caactgtttt aacgctgaga agttcacttt 98940 caacgccaac atagttgtag gtgttcgcac caccctgaag gattatagaa ccgtcttgag 99000 cgtcgtccag agcaacaact gtcgctttgg tgagcaaccg ttcatcttgt ttttgggcta 99060 acttatcggt gtcgacttta gcgttcacca aaccgccgcc gccaaacaaa ccgaagaacc 99120 ctctgccgta tccagccatg atctaagtcc tcaacatttt cttgtaatta gtgaggggga 99180 ataacattcc cccagcaccg aggacattac aatgacttgt cagaaacggc ttggaaataa 99240 cgcaagtcga cagtgaactg tgtgtaagag tccattgccg acatatcgag ttccaattgg 99300 ccgaggtttt gaggccagcc accctgcaaa gtccatgtct tagtcacgtt gtcattcgcg 99360 tccagaagtt ccatgatgat atcacggaaa taatcatctg gattcgcgct ggcgcggttg 99420 ttttcactac cgttgatgaa ttgctgccac acttcaaaag cattgtatgg agcgttgttc 99480 accacgttaa tgaacgtcac aggaagcgct tcgaaacgac gatcccctgg gaacggaagt 99540 tcacgaccac cccagggcac cagaatttcg cccagttgac ctgttggggt gttggtggtt 99600 acagccagca aggacacgtc acgaattgtg tcggaaccag caacaaaaga aggaaagttt 99660 acagtcacac gccagcggtg ttggcgttgt acgccgcccc ctcgtgacat ggctgcgcga 99720 aactcattga ctgtcgccat ttttatatct ccaaataaga gtacacaatt ctaattagtc 99780 gtcaatcttt taatcttcat ggaagaaaaa tcaaatccgt ggtcaacatt gcttaaaacg 99840 ggttcgattt cacacaattc ccaacgggga tctatgagag aaacaagacc aatgtgttca 99900 cctgtggatg tcaattttgc tgcagtttta cccagcatat gacttccatc attaccgcct 99960 ttattcatgt tgtaacccat ctcataagaa ttatattgag cgatgagttg cttctctaat 100020 tcccatttat ggacttcatc ggtctgagca attacaacga aagtaaatcc agatgttcca 100080 tacttacgca tggcatcata caattcactt tggactccat gatgaaaagc attcgcaaaa 100140 tgctgatcat atcttcgttg tgggtgattg gtcacaccga tgtagacctt tccattagtt 100200 atcgtttcaa ttttgtatgc gtatatcatt caataactca aatcaataag acaaaggaaa 100260 accccgccga agcggggttg gtcattttat gaagcagcaa cgatgccgcc accggattcg 100320 atttcgctga actccatatc tggtcgaact gcagcaaagt caagatacac ccaatttatg 100380 ctgtactcgg gcttcaacca aatgccagca accatttggt tcgctgcaat gacatcagca 100440 gtgttgttgt cttcatcaca tttgacttta ccatcgtaaa tcgcacccat atttgccagt 100500 tggcgaatat aaggacgaac cgcattgctg aacagactac gtgtaaacgc gtcattgttc 100560 tcaccaagat agtatttggc gattgcggcg atgttctgct cagccatgat gaacaggcca 100620 cgaacgttga tgcggtcaaa cgccgacggg cgggtcaggc cagttttgtc accatacagg 100680 acgatgcctt cattggagaa ggttacgatg ctgttgatct gattgcggta caacacagca 100740 cgttcatcag aagacgcaga ccacgccatt cgattatagt tgttatattt accacggttg 100800 tggaacgccg gagatttgta gatacccgcg atttcaatgc ttcgcgccca aacacctgcg 100860 gtgccaccac aagccggaat ccaacgcatt ttgtcgttgt acttgtcgta cacatatgcc 100920 cagttatcat ccatgaagaa ataagaagag tcgcgaacaa ggctttcacg ccaagcaacg 100980 acatcatcca tttcacgacc acggttgcca acaaccgtat cacggagcgg ggatacgaaa 101040 gatacagtat cttttcgctc agtagataag tcgatcaatg cttgttgctc aatcagttct 101100 tcacagtacg caaatactgg cttcgcatca tatgcttcag cattgttcaa gacttggata 101160 gctgccacgc ggttgatgtt ataatcgtct acgccgcctt ctaattcaac gacacctgca 101220 accagttcgc tcgcgaaggt atacacccaa tttgaagtat cgttgatcac gtctttgaag 101280 tacgcattcg cgccatcgga ttttttagaa ccctgggtgt tctgcatcag ttcgtatttt 101340 tcaatgatgg aaccagaagc gccaacagta gtgattacgg ctgttgcagt cagtccttta 101400 tcatcaggaa cgatagctgt aacggcctga ggaccgatag ctttatgtgt cacgatgaca 101460 gtgttggact tcacgacaac agaagaataa acacttgtca gggaagttag cgctgtgccg 101520 attttggttg ccaaagtggc tggagtatca gtatccagat atgcgatatc ttcacctgcc 101580 acactgatgg tgccagcagc agtagccgta ccagaaacgg agatacggtc aacctgaccg 101640 accgcgccag cagagtcggt aatgcgacca actttgtcta cgacaactac atggaattca 101700 ccagactgag gtgcgtatgc aaagttatta cggaattccc aagttgagaa cccagcagca 101760 tcacaaacat tgatagcaat atcattaccc agggaacctg gataacgacc agtccaagtg 101820 atggacgccg aaggacttgc tgtttcaaaa tccagtttgt ttttgatcgc aatcgctgtc 101880 tgacctttgg taacagagtt cttggccaga ggaccaacaa cacgggtcac ccatgccata 101940 gagctgtaag acaaaaagtc cgcgattacg agaaaatcgg tcgcagtact gtcgttgggt 102000 ttgaagaatt tcttcaccaa acctgtctca ccaccagtca ccagcactgg aagttcaact 102060 tcaccccatt gaaatttgcc gacggtcgcg ccctgaacaa caacggacgg ggacgtctga 102120 agcgtggcat cacgctcagt ccactgaacg gacggcgcaa cgctgaagct ttgagttgcc 102180 ataatatcat tccttctcgg tagagtttcg ctcaatttga aagatattta gtgatcaatt 102240 cttaaaccac tcatccatgg tcatccctga catttcgttg aaaacttgaa tgcccccgaa 102300 accaggcaaa tgctcagttt cggatggggt gtctccaacg actaaaccac caaatgggaa 102360 tacctgctga gattcagttg aagacattcg gtttctcatg tcctgagaaa tacttgtaga 102420 tgtcaaatca ctgaaccatt cttgttttac cgcccatgaa tataagacca acggcatgac 102480 acagtcatcg tgacaaccgt catcggcttc ataccgagcg cctttgaaca caaatgtact 102540 gagttcatct atcgtgtcct ggtcttctat caccaacatt tctttctcaa tgagcgcttt 102600 caggttagca caaccgatag atcggacttt tctgttggta ttgataccag gttccggttt 102660 acgtccacca atccgtttcc ccgtcccttt gttatctgtt gatgtgaata tgatttctgg 102720 atattctatc tcttgataca agatcgtgat aacctgaccg ccgacgtcgt tgtttgtttc 102780 aacaaggaca ggacattccc cgtattcggt gcacatatca gctatcgtgt atgcatacat 102840 cataggaggt atcgtattat tcctgtactt ggctgctatg acatgcggat attcagttat 102900 atccagaatt gttaagacgg aataatctcc ttccaccccc ttcccagtgt ccgcaatccc 102960 aaagtagaga cgttgtgggt cgtattcctt ataaatcttg gtgaattcat taggttcccg 103020 atacaacttg gacgtcattt tatctaagca tttggccgga atcaatgaac ccacggaacc 103080 acggaactta atgccaaatt cttgatcgaa acgagcatcc cccagacggg cacgttgttt 103140 ggtttcccaa tctggatctt tggtatatgc cggaacctta taccatggga cttcagttag 103200 gtggaagtcg ttgtattgtg gatggcgcgg atctgctttg gtgacaatat catagaacaa 103260 ccctcgctgg cctttcggag tacttgtcaa aatacagcgt gatgtatcgg cagatgcaat 103320 ggctgggaaa gttgattccc aaaattcaaa gtcattttcg atgaacgcta cttcgtccac 103380 gtacaagaga gatacagaac gaccacgaat agagtccgaa gacgttgcat aagcatatat 103440 cttagaacca ttctcaaact ctatcagggt agaaccaaac ttctcacaac cctgctgaag 103500 gaagaatgga aggtcttggt atgcctttct gatacggtca agaatttcta tcgcttgttt 103560 ctctttgttg gccagtactg caatttcctt atcagaatgg aacatcgcat accaaagaag 103620 aaacgccgcc accacggtcg tgttatgact gagaaagcca ttcgtgtaat aacgttgatc 103680 gctggacttg acttgcaagt catacatgtg gtggtactca ccagtctccc agatctcaga 103740 gatgaattct attccctcct gggtcattat ggcatctccg gcctccatgt ctttagcaaa 103800 tacttcgcgc ccatattcat tgaagaacat gtgctcatct gcgacatgaa ttgtgcgtcc 103860 ggtttcagtc ctgacaacgt attcagcgta ttctttcgtt ttatgagcgg caataaccgg 103920 aacccagcca gtgtcggact caacaaaata tcgtttcccg aaacggctgt ctacaaactt 103980 attgtggttg ccaatggtat tcagtggcac agcatggttc ggtccttcga agcgcttgtg 104040 aagctcttct atggtgagat gcaactcttg ttgactgatt gtatcataga cataaacaag 104100 agtatcacca cggacgcatt taccggactg acgagcctgg acgaccgcat tgaatcgata 104160 gtcctgaaag tcatggaaca attgtttctg ataatcatgc atatcgaaaa ggataaagcc 104220 tttatcgatc gtggttatct tgtaatagtt ggcggcgaag taatgcgcgt ccattgaaca 104280 ttcaacgaat tcgtcttctt gttcatctgt cagcattaac tcgactcgag gagcacgcac 104340 agaaggtttg cgcatgaacg tttggtccat acgcaatttc acatcgtcta ttttgaaccc 104400 cgttttaatt ggggcatatt ctatatcacg cttctgatac gccatcgtct tcttccttca 104460 cgtcaatcgt ttcaccgtcg ataatttcat cttcggtttg ttgggtggct tttgcctgag 104520 cgcgttcttc agcgcgacgg cgggcatctt caatcgtctt caataaatcg cgagaagatc 104580 gcgccttttt cccaaccgat actgttgttg ttccgtctgg tgaagttgta acatccactg 104640 tcgtgtcatc aacaggtggt tctttatcac ctgttactgc cttgatggtt ttctggtttt 104700 ccatcaagtc tttattcaga cctcgcatga gttcacccaa ttcacggaaa acagaaaatg 104760 ctcgcggagc ttctgtggat gcagccaatt tagcggcttg tcccatcatg aacattgtgg 104820 cttcttgcat ggcatatgtt gtgtcgcgta tccgtttgta atccgttgta gcatcagtgt 104880 ccgcaaactc aggtactttg gattccttgg aagcaatatc ctccaatgaa ggcggttcag 104940 gaatcggctg atacccttcc ggacgttcac caaaccattc acctgtattt tcatcgaagt 105000 caatacctgg acgaggggcg acagcctcca tcgcctcctt cccaacttcg tctcgggcgg 105060 tcactgcatc aagcgtggcg agtaaccttt ctgacatatt gctcatgatc aatcctccgg 105120 atgatgtatg ccgtctttat caactcggaa ccactcagga agttccgacc atggcatgtt 105180 caaatcatta gacatttcaa taattatctc tttgatgacg tttggatccc caccgcccga 105240 accatcatca acccaataat cttctccata gatgtgtcca tgtaattgaa aattaaaggt 105300 gcaatctata tggggtgatt ctgttgcgtc tccttcccag ttgtcagaaa tcgtgtgatt 105360 taccaacatt atcttcacgt tctgatcttg agataaagta tcgttgtctt ttatctgaca 105420 atcaatagaa ggagtgaaca cagaataaat ttgttccaac acctgtagca tttcgaccag 105480 tttcttcgtt ctgatgttat attcaaaatc tataatgatc ggaattcgtt gtttggaccg 105540 cgcagttgca gtcgatatct gattatgata cgacttggtc acctgtttat tgatttcgaa 105600 ctgaccaaag gacattgttg caaatggcag catattggct ggcacgttcc tgttgaggtc 105660 attacggcgg ccaatggcca tatgcagcgg gatttccatc aagccacgtt cggttttgac 105720 ttttaaatcc gacatgatag cgttgaaaac atggatatat ttcaacaacg attcatggta 105780 gaaatatttt tcaaatggtc tggccatgat tattccccga agtctatctt cattttattg 105840 ggcgaaagat ctttctctat ttcgcccgca aattggttat ctgtctgtag actggcatct 105900 ttatagacac catcgccgtc tagatcctgc aatcgtttat caatatcgtc tatttcagat 105960 acacctgtat cgaaatcttc gttaccgtat tggaacagcg tacatggtag agaatatgtg 106020 taccatttcc cgaattgcat gaattcttca tcgttgttag ggttattcac tttaaatatt 106080 ttgttagcca taggcagata tatcaaatca ccttcttgag gcatttgttc aaggcctgga 106140 ccattaccaa taacttctga aaaacgacga cgagcaatag tgaaggtcac ttcatcttgt 106200 aattggatac cgccgaactt ttcccacatc tgtgtgttga agccttgata atcctgcatg 106260 tacacttcga tgtcaaacgc ttggtcgaat ttgtgttcgg cctcgtttaa aattgggtat 106320 ttttcaacaa tagaacgtgg gatatacttg atgtcaatcc cacgcaattg tatcatctcg 106380 accaccaagt catcaattaa tttttgagta ccttggtgtg ctgtatagtt gaaatatttt 106440 gaagtagcca tgactttacc ctcaattttg aaggtattta gtcaatcatt aattcttttg 106500 aggaattgat aaatgaatgt tgaagatatt aaagaaactc gtgacggaag gcgtgtgaga 106560 attatctgtg tagatgctaa aatcgccgat ggttcatata acattgtggg tcttatcaaa 106620 gacgaaaagg gtaatgattt tattgaatgg tgggacgaaa agaacgtggt tgatggttat 106680 attctagcaa attcagatcc ttccggacgc gacatcaagt tataaaaaga aaggcgggtt 106740 atcccgcctt ctcttatccc atcataaaat cgatagggta ttgctgacca gtacgcaatt 106800 cctcctccaa ccgctctatc tcggtctcag cctcactgaa catactatca ccatccagtt 106860 cgataccacc agggagacgg atgcctcttg ccttcttaag cacctctgcc caacggcgct 106920 tgaccaatgc agtcgcatac gctttcaacc acatatcatt ccatgcttca gcgttttctt 106980 ccgattcggg gtcgatattt tgataacaac gaaaagccag agtttcatca acaatggcag 107040 caaactgcgg gtaaaggcgt cgctggaact tcttgtacac aaaattacgg cgaacattta 107100 agacgcttgt gatatccgac aggcgttgtt gcatggaaac ataatcaatg agacgaatag 107160 aaaccagcgc tgctttgggg acaagcattg cttgagccat ttgccattga ggagttgccc 107220 agtttccgat tgactcaata ggaggtccag ggataacttc aatcacatcg tcaatatcat 107280 cgggaaattc tatatatccc ttgtcgatat cttcttgttt aacttggtac aggaagaacg 107340 catcttggct accatcacga tgatattccc aaaatttctg cagagcatca tcgactgcat 107400 cttcgacttg tgaactgtca aggttaattt ggatcacggg agcgcccaat ttacgcaaga 107460 cataattcat aaaagatttt ttgtctcgaa tcttattgac ggccattgtt attccccttt 107520 tgctgcaaat cagatacagt aatccgcagt gtgcgaacat catctgaaag actgctgcta 107580 ttgagtttta actcagccat gttttgtttg acatatgcga ggtcagtatt catgatcgcc 107640 atacgttcac tcatgtcatt cactttctga agaacttgat ccatcttgtt ggaatctcgt 107700 tccaatacat tcacgcgcgt ttccatcccg cccatgaacc aaaggaacga tgctgccgag 107760 accaatgcag aagccacgac agcggttaag ataccacgga tgtcaagccc cgttctttca 107820 gcttgcgtcg ccattctgac ctccttcggg gatttcgatc cccaactttt cggccatcat 107880 tttgattgtc gcctccagat tagatatctg gtttgattgt tcaacaatgg tggcttcacg 107940 ggtttcattg cgttgacggg cttgcaatgc agccatgcca gcggcgtgat cggtgcaaat 108000 aatcgcgcca gggcaagaac tgcttctcaa catggatgcg tgcccctgta ctttcactcc 108060 acgcatatct ttatcctcta ttggtttggt gggctttacg cccacctttc aacattattt 108120 atgccagagc aataagacgg aagtctttga atgaaggagg agcaactcgg ttccccctta 108180 caagtgctct gacttttaat ccaacgaacg gattgttgct tgccacagtc ttgtcatact 108240 catattcaaa gaatgtggaa ccgtcgttaa ccaaaggcga agttggggcg acgtcttccc 108300 aagccacact atccatctct tgccctgctc gtagaagttt cacctgcacc ttcatcgaag 108360 actgagaagg cagcatcgcc ccgaagaaca gtttcacagt cgaacatggg ttatcgaaac 108420 caatgtcctt tgtgacatat ttgaaaacgt cttcaaaagg atctacacca taagagttga 108480 agatcacgct caggtcatca ccatcaatca tcggtgctgt gtacacgttg ttttcactac 108540 gagtcatagt agcacgaatc tggaagtcac caacctgacg atagatacct tcagtcggca 108600 atgccacgtc agtgtcagtt tcaaactcag cccaatcaga catagaattt gaagtggcat 108660 cgcgataacg gtattccaat ttcagaattg aaccttccag agccgaattg gtaacgctgg 108720 catagaacat atcaaccaga taattgccca agaaagaagc attatctcca ccgatttgtc 108780 cattgctgtc tgctgccgta ccgacgtcaa tcttgaatga agtatagctc gcatctgtca 108840 cagtaaacgt tttgttaagt tgttcaggag taaagccaca accgcctgtc aattcagaaa 108900 gagtaacatt gttcccagca accaaaccat gaccaggtgc aaacacagtc acaacagaag 108960 acccgcttac gcagttcaga gtgttcaatc ccaacggacg ttgttttggc ccgagcttcg 109020 gatcaaatgt tacaacgttc tgaccagccg caaagttgca acgatatatg cggaatttca 109080 tatcggccat ttggttcgga gaccaagttg aaccgtttga agaagtgaag aacacccctg 109140 tatacggttg tttggcgata tattcgttgg acagaaggtt tttcttgccc atttccgcga 109200 tatacgcgtt gtaatcctga gtattcgcca acaaaacgat agcaaactca gtcgatgctt 109260 gcagatacac cggataatca aaggtgaact tcgtaccgcc ggaagagtct gtagagatcg 109320 tcacttcaga cgggttcaaa gttttacgag taatgactgt atgagaaggt aagccattct 109380 ccatctcgcg aatttccaga gtgatcggaa catcacgtga cttggtagag aagaatactt 109440 ccacgccttc aatatactcg ccgccattct tagtcgctac cataaacgat tgggcaatcg 109500 gatcacgcca ttggtcgacc acaacttcag aagtgctggt ttcggtgcga gtactagcag 109560 tgtaacccag gacacgagtg ttgacaaagg tcttttgaat accttgtttc ttaccgaaag 109620 attatatgaac aatttctgca ttggtcagtg tatcatccgc agatttactg tcaacagggc 109680 tatccgttaa gcggaacacg ttgtcgcctg tgttgaactt gattgtatcg ttctgtggaa 109740 cgcggaatat acctttaaca gcaccattgg catcagtggt gattgggtca ccgaaattac 109800 caccattcgg tttgcaatac agattgacgt cacgaccaga gaagaacgca tacatacgag 109860 tgaaaggtcg cagcccagat gcgtcgaaag aaatatcgat ctcgcgcatg tatgggataa 109920 cttgcgtctc cacaatctgt tcaccagtca tggtcgtggt tgttttgtcc gtgtatgtat 109980 atgtggtgac atcacgggca gaaacagtcg tgcggtaacg atatccccac cacacaccac 110040 cagcaccatg cggttcccaa acacgatcag aaacagaaac agtacgccat gttccgtaca 110100 ctgaaccttc ttgtacagta ccacgggtgt tgatcgtttc attgataata cgcggtgcaa 110160 cataatagtt ttcgaaccag tagtctgtgg tcgggttaat cttcaagaaa ccttcccaat 110220 tgaatactgc atacgggtta acgttgatcg tcgtcgtcgc atattcttgg ttcaccgaga 110280 tttcaggcgt gtaattgcaa accaccatcc catccatcac tttgttccag ccaacaggag 110340 tcatgtcaac aacgttttgt tgtacaaacg ggcgcagacg tccgttttcg gtatcgatag 110400 aacccatcca atcttcagac aagtcatcaa tcaaccggaa gtccttgaac ggatcagccg 110460 caataccatt tttgaaacgg ggattacccg tgatggggtc gaacacttgc tgtgtcatcg 110520 ctgaagattc cagctgtgac agggaggtat agtattcaac attggaaata cgggtttcca 110580 gtttaccgat atcgcgcatc gtataacgac gattatcaat agttcgaatt tggatatcat 110640 caatattcgg tgtatacggc gggatcaaca attcatacaa acgcatggcg ttcgctggga 110700 ttgctggaga agccaggttg ttagaactaa tgcctcgagc cacaccaaac acaccgttgt 110760 ctgccagata aatcgcgtca atacgcggca gataatattc tgtgtccaga ataactgcag 110820 tgtttggacg aaccatatct gtgtcagaag ttccgttggt gattttcgga cggaaatcca 110880 aactatctgc caggccgtac accgcgcctg atgtagaaga tgtataattc gggatatctt 110940 tataatccat cgaagtatac gaatcagcag agaagaaatc accggaactg tgggcgaagt 111000 attgatacac cactgtatac gtccctgaga ttgctccagc gctggataac aagttagact 111060 tgtaataccc tgcatcacgc tgtccgccat ctaggacgaa gctggaggtc acgtctgcgc 111120 cagtatcgtt tttgaccgat accaatttcc aaccatcgtg attcgccaaa ggacggctag 111180 tctgcgaggt gaacgtcact gtttcagttg tttcagtgat ggtcttcgtt ttgattgtgg 111240 ccgtggtacg aatcatcagc gccagcaaat tgattgactg gttagcatta ccactaccca 111300 gagaaatctg cagcgccgaa ccgaccggag aaccagtcaa agacaaagaa ccagagatat 111360 cgaactgcgc ttccgaacca tctgatttcg ctgcagagta caacgaaaat tctggggaaa 111420 aactatatcc caatggagca gaaatagaac ccgcgccgct gttgtccaac gtcactttat 111480 acgttctgag aacagtgtag ttgatatcca cggagccagt tggtgctaaa gtcttgacac 111540 cgaataccgg aagagagaag atcagatcta tcatagaact ctggttaaac tgattggatt 111600 ccagttcagc agagaacatg gtgataccgc tttcttcgta agacactttg gtgatagtgg 111660 atgcatcgcc agtaacgacc aggtcgcgca tatacagacg aaattctgtt gaattacgtt 111720 cagctgatat acaaagtgct gtagcctggg taacgcctga agcattcagt aatttgtatc 111780 gaacggtgcg ggatatcact ggcacacctt tagaattctt ggtgaccaga taattgcctg 111840 tggccaccgc aacaggggtg ttgttcagga catcggtatc ccgcgcctta tcaacgatca 111900 ccaactcttc cccgacgttt tcgatacggc gaccgcgaac ataggaaata cctggtttca 111960 ttacagacac gaatttactt tcgtcgccgc catcagcagc attgaatacc ccgccattgt 112020 tattgacttt caggtgttca cgaatatcga tctgatgagt cgaaacgtta taatcaccat 112080 tggtttcata agtccgttgg gctaacgtgt cttccagaat attataggta gactgagtca 112140 ccatagactg gattttacca tcacgaactt tggccagttc aacaaagtct tcaaccacag 112200 catcataatc aaatcgagat aagaccagat ctattcgaag acgatgagcg cctggggctt 112260 tggagttaat cgttccctga gcatttgaat aaagggattc gtcttcagat tcagtcacga 112320 tggtttcagt gactttaaat ccgatgcggt gggaagtgat gttagaagtt ttatcaacga 112380 taagagttgc gtcatcaacg tctaggaaca tcccacgaat gaagtaaacg cctttcgtca 112440 tacgagcgac gatagaacca gtcaccgcag ctgcgatacc ataaccaata cgaatgaaat 112500 tatcattcac gtcgtaagtc tggaaataca gattatcgtt aacatggaat ccgtcagcat 112560 tacccgcttc agtcatctca aggatagcca gcatcgtatc aggagcagac agatcacgtt 112620 caagagacaa aacacgcgct ttggcgttat tgtctttccc caaaacgtag agttcagaaa 112680 taccttccag atcggtgaat tcagtaccac ccgccaaagt gaatttcaaa gagactgcgg 112740 cgttggtgat cgtcagaccg ccagggataa ccatagaacc atctttgaac aaatggttgc 112800 ctaatttttc aatttgatcc tgaagaatag tctgcatctg gttcagttcg cgagtctgaa 112860 ccttgatagg catcggacga aaaagaatcc gtgaaaaacg tttcccagga ttccagtcat 112920 cccaatacgg gcgacggttt aaatttgtag attgcatttt gatgctccat cgagtgccat 112980 tttatagaga tatttagtat acaaccaaca aacagataga aataaaaaac cccgccaaag 113040 cggggttttt attatgatac ctttgataaa gtaacccacc ttcctaattg ctcaatgaac 113100 tgaattgtaa ttttcatacc atcagtcatt ggagtcaaac ctgcaccatc gattgtttct 113160 gtagataata aattgaaatc agtggcacca ttacgaatga aggtaacagt ctgcccatca 113220 tacccagcgt gtaaggtaat attaccagta ccctcaacaa tatatgtgtc aaattcatat 113280 tgtttcaaag ttaacggcgc agaaattggt ttacatatcc gcttaggcag gaaccctatg 113340 gcattcttgt ctattggttg gaatggggtg ggtccagtac caacactagc aggagcacgt 113400 tcaatgttag ccccattaca tagatgaata ttaaagatat caatttttga catcttccat 113460 gtacgaatat ggagctgaac actataagta tcactgtcaa caaattgagt aggaacactg 113520 tggaaatgct caacaatctt actaccacca gttaaacgga acgctttact gtaaaggata 113580 tcaccagtaa tagcctgaat cttcagcaaa aattctgcat ctccaggata accgacttcc 113640 tcaaccatac gcaatgcaat cccgaaagac acttcacgca ggaaggctgc agtaacgttt 113700 tgactaatca cgtaataatc agattcggtg gcttctcgat tagcaacaat acgagaccca 113760 taacgatact gtgtagaagc accgccattc agcaaaccgg aagtaataga caggtcacta 113820 gtctgcgcag ctccaccaac agccaagttc cattgtggtg ccagtaagtc attggaactt 113880 acgatatact gattcacctt cccctgagca ataatctcac gactaccttt accaattact 113940 tcagcctgat tcgacttaga cagagcagat tgcaagttct tataggtaat ggtggagtta 114000 cctacagtaa caggaacacc gttatcaact acatcatcca acatctcaat ctgagactgc 114060 ataccaccaa cttcatatcc aaactgtgag cgagtattat tacccccgtt cttaatctgg 114120 taacgggcat aagggccatt caccaggcca ggtgagttac aggactcgat ataaccgaag 114180 aatacgttag tagaaccatc atctacaaat ggacgtgagt ttactgtacg acgacaatac 114240 tcaatattgg catacacttc attagtgtta gaactggtat caaaagtaat accaacttcg 114300 caggtagacg ggtcaatctc ggcattacta aagccaccac caatcttacc gaagatacgg 114360 ttagcgttag ccactacgca tcttacgcca cgcaatgaat cataacattc gcccacatag 114420 atggctctgg tgaaacaagt atccagtttc acattggttg caaatccatg tactacgtga 114480 ataacgttag ggattcttcc ttgccccatt aactgaaatc caattgtttc atcgataact 114540 acagaatcca gtgtgccagc ctcttctgcg atctcaaata tcttgccagc tagctcacca 114600 atttcaaaca cacatccagg agacctgttg acaaatgcaa ctcctgttgc tgctgtgtat 114660 accaccttgc gcaatttgat ggtcatcaca ttgaagtcat aacgcacagg aggtgtatgc 114720 acttccggaa cttcataggt attggctaag tgatactcac catcaccaat tatgttggcg 114780 ttggcaggaa ttgcaaaatc ccacatgcgc tgaaacattt ggtcatcatt ggtatccgta 114840 tccagtcgga acatttcagg agtgacatat ttaatggcgt cgttgacagt gccgttaggc 114900 aaagaaactc caatttaccg ccaagcacct aagccaacgc caccagttga tgcaggagtt 114960 gaaccaacag gaacaacttt aggtaatgca ccattccaac gatatagact caccccatcg 115020 ctcacgactt cgttcttgac acgaatcgta aatccagaag tgaaattttc tatcagaatg 115080 acgtattcct cacgcaatac ggccagcgca cccaaatcta cagtgcctcc agagtgtgtg 115140 aggatgccgt cgaccaaact ggtgactgtt acagcaccaa tgttagaagg gagagcgtag 115200 gcacgttgag acaacttatc gtagatcact ttataacca acaatgactg tcccgctttg 115260 gcataaacga cttccgactt tttacaccca aatttacggg caatactatc tttgttcgat 115320 tcttttgaag tagaaccttt tggttgagca aattgcggat tcatgatgaa tctcctgttt 115380 ttctaataaa ccctcccgaa ggagggggaa attaaaatgc aacactgatt ggagctgtgt 115440 atgtgccagg tgggacggca ccagcccaat atgcgatagt tgccccactc acagcattca 115500 atatttcgga tccaagcaag gcttgcttat tagtgaccgg atcaactgca aacaccgtag 115560 ttgttcccac gtcagttttg cgccacacat taccttgaga tttaattgtt aaacctaaga 115620 cgccagcaga ctgtcctgaa ccacccgaag acacgaagtt tgtggtatta ttcaaataaa 115680 cgagacattc ttcaaagttc aaagtacacc aaccaacaag actgaataca gtaccattga 115740 atgctgtatc tcccgtttca aaatatgtcc ctttgaaaga aagttgagta ctggaacgta 115800 agtatgttga agtgttatac ccttcgatcg aaccgccgat gaacaccaca tttcgaaccg 115860 ccaatccata atcgccaatc tggtttacat aagcacgcat attgatatgc ttggtattga 115920 atgttatatc ctgtccggat ggaacacgac taatacaata acaatacaga atcgtcatat 115980 gatccgtagt ggaataataa tcacctttgc tggcatccca tggattagaa tccaacgcgt 116040 acttcataag cgccacagta acatttcgca cgttaatggc ctttccatga cggaatgctt 116100 gggtgtcaca atacgaagcc gccgaaggta atgatgtcgc caaatccatc ccagtagttg 116160 taaaccctct tccgtacacc aaacaatctg ttggtgatgc accttcacca caacggaatg 116220 cttctccagt cgcagcatca aagaagacag cattttgtac agaacgcgct aaagaaggat 116280 cgaaataac gtgcaccccc tggaaattgc tgggctggaa tagttcagaa taaacagaag 116340 tcatttgggc gtatgaacca aaagtctgtt tattgggaat atcaatataa ctcgtaatgc 116400 gatggcgacc tgtccatctc cagcaaccac cccgatatgc cacgttggcc acttgttgga 116460 attctttggt actgtcatgc gcgtccccga cgttccaagg aagcgcacca aagtcttcag 116520 cgcggtaatg acccatcacg tcttgacgac gccaaactcc agtacctgtc ccgcttgcgg 116580 taaaccaaga agtcttccct gcgctgtccc aagtcgggaa cgttttacca ggatcgatga 116640 tcgtgccgcc gttgtgagca gccttgttcc cagaaggatc ccaacggaag aaaccaccac 116700 cataattggt tgatgggtgg aaagaagtca caaacacgaa ggtcgtttca gttggagaca 116760 cattcaaaag ttctgccata ctaccaacga cacggtgttt attgatatta ttcagaatat 116820 cttgtactgt gtctccactg gaaactttaa tattttctgc gccgcttggt tgtaaataga 116880 ataatttaac cgcctgagaa gaatctggta atggtaagag atcaacctgc acatcacctg 116940 ggttgtaatt caatttcccg tctgagatcg tagaaatgac agaaccatca ggaatggttg 117000 gtaaaccata actggtttgc gtcgctatgt cataaacaac tttcttccca tccaacaaag 117060 atatggtgtc cgtactaacg atgacttcag agtctttcac attagcagaa cgggcgattt 117120 cttgaatact tcggtcaaac gccggactga tattcggttg tttaacagac atttcagcga 117180 ctacccaaac gcctgcagtc agtgcagttt gcaaagacac tttccctgtc gtgctgttat 117240 aggaatattc aatttcgggt gttttgtact cgccaccaat ataaagagat tggactccat 117300 aagatgtgaa atcaggagta aactcggttt cccctcctac ggcctgaaat ttgtatatgc 117360 ggataccttt ggctgtatct tctggtgaaa gaattttatc gaataagcaa tacacaacat 117420 cgcctttgga caatgcgcgt ccgagattca acgtatttcc ttcgatttca aagttgtcta 117480 acggaacttg cataccaccg ttgattgtga taacaccagt gacgggatag aacggcaagg 117540 aaagaaaagt ttctccaccg acatttgatt tatacgtgaa aggaatctgg tggggagctg 117600 tgattacgcc gccgaataat tcttctacat ttctggtcat ttgaaaatac cccataaagg 117660 atttgccaat atggggtatt tagtctgaac taataaaatt tatgaacaaa ggtataataa 117720 gaaccccgcc aaagcggggt ttttgctcaa gataaattaa agtgtgtatg ttacataact 117780 tccatctggt tttttagcaa gcaacctcaa tgctccgtca cttccgaaga agaatcctat 117840 agatgaatta tgttccagag cgctctctgg taattgtaaa ggggcagcag gtatactcat 117900 atgcttaaag cctaagcggt taagctgaaa ctcacctaca cgtacaccct cctgaattgc 117960 cgaaagcttg acaatacttg cctcaccccc tggtgtagca acctggcaat ctgccgtcat 118020 aagcaaagat gggtttgtag taccacccat agcaggttgc attgcaagtg tcatttggtt 118080 ggcactatgc tgaacattga tattacctcc ctgaatatcg cttatatagg tacatagtaa 118140 tttcttagta ccggaaccag cacaggaaac attacttact tctgaagacg gagcgtatat 118200 agcgtaacct tgtgtagtat atgcatggat gttaatacca cgaagtctac tacctccctc 118260 acaggtaagc tgatttaagt tagttaaatc cttattcgca cctactacag taatgttagt 118320 aatatcattg ttagtacccc tatcgaagac gccttcctta tgggcctcat aagtaacaac 118380 attatcaata atatttttct gaccatccca ccaagcacca atccccatac aatcacgagt 118440 aataatatta cggatgatat gttgagtagg taggtggaac catggatact ctgcgagtga 118500 gtagtcatcc acacgttcag ttggcgaccc tgtgtcagca ttaacatcaa taccatcata 118560 gtaacactgg attgtagtta tattgtcgaa cactaaacgg tagttcctgg ctgaacgacc 118620 tccaatttcg ttctgatagg ttttaatacc tgattctcca acacggtatg agattaaatc 118680 tcttactcca ccatcatggt ctgtaccacc atcattgcga atgaacagta cagcggaacc 118740 agagccatat ttaatctcac ccccaacaac ccagttgcca gtaccccatg cagttgtatg 118800 atggttctca aatgtaatac ccgattccaa agcaataaaa ttgcgtggat tcttaacaag 118860 aatcctatta cataaagtaa atagataacc accaaatgta gcttctgggt tctctacgat 118920 gatattatcg ccgctcatta ttcgcaaagt agcaccagca acctgatttt ttacattatc 118980 aggaaggtcg tcccaaatat ctaaatcgtt aatatttggc ttatatccaa catccaaacg 119040 ctgctgaaca gatgccagaa cttgtgttgg gtctgtaacc caattaccgt ttgcatcgaa 119100 tcggtaaaca gtatacggcg tagttttagt atgcatgtgc ggtttcttaa ttactgaacc 119160 cgcacccaaa ccattccaaa ccaacatacc atcgccaatg aattttcctt tgcattcaat 119220 gattaaaact ttaccgctaa aatctacact ctcatctgca gtaaaagtgt agtcaacatc 119280 aataagcaat ccatctacgg ctgctgtcgc tgcatcctgt aatgtagaat aatcagataa 119340 ctttactgaa tatttgaatt ttttgttggc ttcctgtcta aatgctgcgt caccaacact 119400 caaccatgca cctaaaccaa cgccaccaga tgtttcaggt gttgagccag catagacagt 119460 tctaggaagt gaaccatccc atcgatattt tttatcatcg tgaacaagaa gttcattttt 119520 cacattaatg gtatggccga aattaaaaga accaggtaaa gtcacatatt cttcgcggct 119580 tactgctaat tccccaaggt caacagagcc agcggaatga gtgaggatgg cttgttcgtt 119640 cagacttatc gcagtcgttc ctgaaacaat acccgaagga agagaataag cccgttgggt 119700 agactcatca taaattactt taaatccgct gagatcaata ccgacagtga aataaatgac 119760 ttcgtcttct ttgacaccga aatttcgagc gatagattgt ttgttaactt ctatggaagt 119820 ggagccgcgt ggttgattga attgagaaat catgataata ccccataaag gatgaccaat 119880 atggggtatt tagtctgaat taacaaaatt ttataaacat ggatataata agaaccccgc 119940 cgaagcgggg tttttactat gatgtaaatt tcattgcatc ccatgttgta ccattatgtc 120000 gatacccgaa aatatttgat gccccagcaa taacatcata tctgtcacca gacgcattac 120060 caaaaggcct gtcaggaaca gaagttgtgt cagttgctaa aatgccttta aaccaccatc 120120 cattctgggt gtttggtttg tatttgtaaa attgtttaac atatggttga gttggcgagt 120180 caacattaat ttgcccatga ataccagcgt atccgtataa aggttcactg gtattcacat 120240 cactgtatac atcaatgttg aagtagtaat cctgtacgga tagtggagct atcccaagcg 120300 ctggatgcat ccatctatct gttttaatat cagcagtgaa ttgcacaaca ccaacagtca 120360 ctcctgctgc ttgttgtaat aaacccagga caccaccaaa ctgacaattt gtcatattcc 120420 atttaatatg catttcagca aggtgaacaa gataatcgtt ggcaaattta ttggtaaacc 120480 ttatggctgt gttgtctgat aattgaggtg aaccgttggt cccgcaagag acaaaagagt 120540 cattgctgtt gaaagtagca cctgtttttt gtttacccaa gcgaacacac ccccaaaaac 120600 ctgagaaagt gttattttca ctaacaactt ctttgaaata gtccaggtca taagcaacgt 120660 ttgcagcttt ttgttcagtt gtccaatctg tggctctgtt tttttgcaat atgattattat 120720 ttgcagagta aataattgca ttaatagtgg ttgggtcaga tgacaaaaca gacggctgct 120780 gtgttgtgaa tgccgcagta ttaggatacc cgataacttg cttttctgat cgtagcgtta 120840 cagtattacc aataaatctg gcaacagttg taacgttagg tacggtatcc agaaccaaag 120900 cactacctgc gtcctcacag acgttatttg tgaaggtgac tatagatgtc gatgtagcac 120960 cgtcgttagc cttcaggaat gggtagcgag cttttttggt gatgcatcca tcaacgatcc 121020 cattaccatg acctcaaat accgtacaca tgtctgacat ggttggctgg atacatttaa 121080 cgttatttat aacgtagcca tcggaatgaa ttcttattga tgagtggtct gttaggttac 121140 tgtttccagt cacagcgtca gcaacgcgat agaagttgca attctctaca cgcgtattgt 121200 agctgttgaa cgctgcctga gcttcctgga ataccattac gtttgcacca ggagcattct 121260 tgacgttaac accagaaaca accacaccgt tactaccttc gtaacatgct actgctggac 121320 agtgagcttg tgctccagac cagttcaatg gcgggacaag attattgtca ccattttcat 121380 caattagcat atcgtggaca tatgcgttct gaatttcacg aataccatca ccgaaaacta 121440 caaagccttt agtgcccccg ttttccttat tgcgctcaac aacaccatcg gcaacataca 121500 gtaacgttgc gtcgccatcg ccgatgaaag taacgttgtt gcgaagaaaa atcataactt 121560 cctgattacg ataaatagtc agaccatgcg ccgtgccttc cacaagagtc gttttatcca 121620 acagataagt gccagcagga accatgacaa cttgctggga tccgaatagt tccgcacgtt 121680 tctccgcatg ataacctgcg aggtttatag catcgaccgc gtctgcaccg atcttatctg 121740 cgatagaata attattatca gccccccagt taagtactga catccagtca taatctgtta 121800 aatatccaac acagtaaaaa tcgggatagt ctggaacagt tcccggcgct actgtataac 121860 caccactttg tatagcacca tatttaaccc agaaaagacc acttgaatca acaagagctt 121920 gctcgttggt ggttaaaact gaaccttgca agaaagaccc aaacttctcg aatttactat 121980 tgatataatt attagctacc cactggcggg cagtggcatc accaacactc aaccacgctc 122040 ccgaaccaac gcctccagtt gttgctggag ttgagccagc agctacagtt ttaggaagtg 122100 taccatccca acgatacttt ccatcagtat gggtgagtaa ttcattttta gtattgatga 122160 cagcaccaga atcaaatgtc ccagccaagg taacatattc ttcacgagat acagctaatg 122220 cgcccagatc aacactacca gcagaatgta caagcacagc cgaagaacta aggctgactg 122280 ccgtggttcc agtcggtaac tctggaataa aatatgatct ctgtgttact ttatcataga 122340 taactttata cccgcttaac acagcaccaa cactaaaata aacgacctct gtatctttaa 122400 cattggttac acgagccact tcccgcaaag tataatcaat ttgattatag atgtttggcg 122460 ttccattgat aattacaaca acttcatcct ctgcatccag ttcttgcgca agagtgattt 122520 tactggttaa tggatcgaat gtgaacccca gatttttata ctggcgactt ccgtttatat 122580 caatagccgg aacatcatca acaacgacgt ctaacgtgat ttcggtttca ccaccaatcg 122640 ctgaaccccc attatagacc caagtaatcg tagaagaact agaaccaccg ccattaccca 122700 attgaatagg agtatattca atcacctgaa gttctgtgct ggctggcaaa gaaggactga 122760 aagtgattac attcccatct agtgaatatt tggattccgc aagacgtttt ccgtcagcat 122820 acacgtccac gattgttggt ggagtattga gagtgacagc acttgtttca gacgccaaaa 122880 tttgtgtaaa gatttcacga ctgtagacac ggccttggcc aagaccgacg ccggatgtga 122940 taacccaacc ttgttcaggt ccagaccaag tgaacgttgc tgatacgtta tcagttgtta 123000 tagccatgtc ttcagtggag ccatacaaat tatttccaga aggagacacg gtcaatgggt 123060 aagtggcaaa tttcccataa gcatcacaaa tagtaacgga atccccaata cgcgtagggg 123120 aagggagaac cactgtagat gtccctgtgg tattattaat gatatagcca cgaccttcta 123180 acaaattgct agagggagcg tgagggagcg tttcccagcg tattccacca ccccccaaag 123240 acaaccaacc accgttttcg taataacctt caaattcatc actatcagga ttgtaacgca 123300 cagaagatgg aagacctgta acttcagtat cttcaggaaa tgtcattacg gcaccagggg 123360 aatgctcaat agtgccggag ttgttgaagc cttttatgtt cgaagactca gaagtttcta 123420 aacccaaagg gaaaagaggc tgtgttggtt tgttggccat ttgtaatacc cctaaatgta 123480 ttcatgtcat ctaggggtat ttagttttag aaagaagctg taatagaata atcgacagaa 123540 caagcggttg tcgtattcgc attaacaacg gaaattctca atttaccacc caccacagcc 123600 cctgtgaacg tcactgtacc gctcgtactt ttctgaacca acaactctga tttgatcgtt 123660 ccgtcacgag ttatggttac tcgatatgtg tcaacaacgt tacctgcccc ccattgcgca 123720 gttaccagta tttgacaaag gttcaccaaa tcaaaatcgg gaagagccgt cgttccagaa 123780 gccgaaaccg tgtatgacga caaattcgtt ttggtacgat aaacggcgtt ccccaaactg 123840 ttgtcgatag aggtcatctt ggcattatac gttgatacac taactttatc actggaaaga 123900 gaactgatgc tgttatccag agatgtcatc ttcgtattat atgtgctgac ctcgacttta 123960 ttacccagag acgtgttgat attggagata ctcaaatcca acgacgccat cttagtgttg 124020 taagtcgagg tgttgacttt cccgttcaac gacgtgttga tgttattaat ctgggactct 124080 agactcagca tatctgcgtc atacgctgtc gttgtcacat atccattaaa tcggttgtct 124140 gcaaacaacg catcaaaaaa tgcagtcatt gtccaataac gcgctccaga atctgtctgt 124200 acaggaactg aagtcggcaa cgttggtccg gtatacgcag acaatctggt gaaatccaaa 124260 ttgaatttgt aatatccgga tgtcaacaac tccccagcca aaccagaacc aggcggggta 124320 gtgtcttcac tgacgccatg ctttctcaac atgctcaggt taacaccatc tgtcgagttc 124380 gttggttcat ctgtgattga aacggatttt ccggcgggaa cttgtatgcc cccattggtc 124440 accaacaacg cattgaaagt ctttttgcca ttgattgttt gttcaccact atctgtacga 124500 ataactttgt tggccaaagt atcattgatt gtgtcaacag atcttttcaa ctcatatgtc 124560 aggcgagcag atggtggaaa taatgggtcg ttaacttcaa aatcgttaat aacgtcattt 124620 ttacttactt tgtcgtcaac agaacccaat atctgatcta tctgctgacc tgtatattga 124680 ctcaggaaat cggccatttt tagctccttg tgctttctag gaatacagta aatccagcag 124740 gatggaaatg ctgacggaag acgcgctcaa acacaccttc aaaatcagat acgtcgcctg 124800 ggactcctat aacataagtg tattcatcat aatagtaatc atcacgcatc cctgtcgtgc 124860 cgtcacattc aaaatttccg tccagaccgc ctatgtcttc tttcgtaaaa tagacgctga 124920 ctggacaacc gaaatatatc caaaagaaca attcaattgc tttcttggtt ccgcggattt 124980 tatagatatg ttttaacagt ttcaaccaac gcggatgatc cagagttctt cgtttagttc 125040 cttcgatata aacagagaac gtatcgcccg tggccgtcaa taaagaatcc gaaccaactg 125100 ggataaaatg accaaattcc tgaaatgatt tatcaacagt tcgttggaaa ccaaaatcat 125160 tataccagtc atctatctgt ttgttcttat cttctattga cagtagcggc cttccgtcag 125220 catctaaaag ttcttcggcg tccagagcca tcatgttctc aaaggtacga accaagaatt 125280 tatcagacaa ataatccttg gcctctgagc ctggggtctt gtcagccttt aaatcaatca 125340 gctgtttaac tggagaatct tcactctcgg gattcatcca actagacgta tctgccagat 125400 atgccaagat ctcttcttga gtgaacccct gctgtctata cagccaattg aagaacgtgt 125460 ccataaattc tatgaacaga gggaaatcat tctggtagaa caacggagtt tcatacttaa 125520 ccccgttgtg tccattatta agatctttgg acatagcgca cctctggctt aacaaccaca 125580 tcaccaatct tgaatacttg gttttgtgta gcctgtatgt tctggttcag tccatccggt 125640 aacacgacta tggtcacccc ttcagggtta tagttagaga ccgtgatctg ctgaaggtct 125700 acaaccccat ttgcataatc tacaacccct gttttttgaa ctaaaaactc ttttgtcgtg 125760 tcattgttat tcactttata catgttcaaa tcgccattat tgtcgcgcat gtagtaagtg 125820 aaatccacct cggcaggaag cggtttgaac cccgttattt tcacagaacc aggtttgata 125880 cttcttccat aactgaatgt aaaactgtct aagactccat aatcgggttt gaaatggcgt 125940 ttataaccaa ccgaagtaat attcgagtta atagaacgct ccatttttgt aattgcttcc 126000 tgcaatattt ctttgtcaaa caattggtca aatccgccga gattattttc accccattta 126060 acgatactgt ttccaacaac aactttcatc tgttcttcaa cgtagactgt agaagtagga 126120 tcccaaaata tagtcgttga gacttggata tatgtgatct cggaatctac cactttgggg 126180 gtgatagatc ccacattata cttgtccaga gcagcaacga tatcggcctt ctcagcgtcc 126240 gaaagtgtct caccaacaga aggtataaca gcgatgtaaa catagccaga atcaggagga 126300 gacagcgtgt caccaccata tgatttagct cgggagacgt tggagaataa cctttcagtc 126360 aatacaccat aatctgtttc tgtaaccgca gcaccatcag cctgataagc taaaggagcc 126420 aaccgtttag tgtcctcaat agattccgga tcgtctccac ctgcgctacg ttcggaaacc 126480 aattacacat cgacctggtt aaacccgcct atggatgacg ctgatgacag gcttgtgata 126540 tcattcccat cagcaccaga agtttctaag tattgaagga atatgacgtt cccatcttct 126600 actcgacgcg aaagataacc atctccgaat tcaaacacat acagaccatc aatacccaat 126660 tctacgaaat acaggtaggc atattggctc agatcaaatg gactgttgta acgttgatat 126720 gtcgtcgaaa cgtcggaaga ctctgattct tgtacttgca cgaccatatg attgatatcg 126780 acattcccag aaggaatcgt atatgttgaa atcgcgcttc cttcaacatc atatgtcttg 126840 tacaaccaat tcccctgtat caactttaca ttgttgaaca tgtaataacc gtctgcagtc 126900 aacgttgccg acactggttt ctcaacagta aagttgtagg aactgccgtc ttttgcccca 126960 acgaacatta cgcgccgatc catgatgatc tcattggggg ctgtgctggc gtcataaggc 127020 gtaactttga tgttgacata catgtatgct gcccgatagt tgtcaggcgt gtaggaaaga 127080 aatgcagcag ataaaccgac gtttgaacgt tgatttgctg tcttcaaatg gccttcacca 127140 ttaagcatgt tttgcataaa ggctatggcg ttcgcgtcag atgccaacaa acgaataatc 127200 gcactaagac cagaaccttc aaagtcataa tctttaaagg tgggatcagc tttcattcgc 127260 tgtttgataa tgtactcaaa ggctctgacg tcgagtgaag gaactgtttg cgtggccatg 127320 ataatctcca tcacctgagt ttgaatatgg tgttgaagat atttagccaa cgggaatcaa 127380 aacgctcgcg cgcgtttaat ttattcgaat atactcgcga gggggctgac gccctcgctc 127440 gtaacaccgc cttgacaggc agtcccattc cacagccatg gaggctgctt ctcgttgttc 127500 gttaacactc acaactcgaa gggcaccgcg ttaagataca gtttcttgat gttgtagaaa 127560 agtagttttt acctattaat aaaccgcgct cctatttcgt tggactttaa ttcaataaca 127620 ccttcactaa tatagtagtc cggtcaatca accgtatatt aaggaacctc tcatgcatat 127680 caacaccgct gtattaaaac acatcatccc tttattagag aaatacgaag ggaagaaggc 127740 gaaggatatt tcatttgaag acatatctgc tgaagtgaaa cgcctgacac gtaaagaagt 127800 caatttccgt cgagtccttc catctgcgat cgatttggca aagtctgatc tcaacacagc 127860 ttccactttc tcctttaaca ttgacgccat gtcaacattg gtggctgaat taacccaatc 127920 atcacaagct cgccgtgacc gcttccgcca tttgtgtgtt gaaaatcatt cccacactga 127980 tcgcatcggt atcagactcg aagcaatccg ctccgaggtg tgcttcacgg tgaactatat 128040 cctggagccg gaaacccagc acatttattt cgtggccatc atcggcttct atggcacatc 128100 cattaatgga tgggctgagc gcgttgaatt aaaagagacg ctgaacaaac acagcatccc 128160 gtctacccat tatatgtcgc gtgaagccgc ccatgaatat gtgtatctgc tagagcgcga 128220 tgtgaagtta aaagtgttaa aataacgctt tattcaataa ataattgtag taaagttatt 128280 ttcatggaag ggagggaaca ctatgtttta catgatgtta ctcctcatcc tcctgatcgg 128340 gattacctgc tctctcctgg gtcgacccga tcagtccggt acacagtcgc ccatttcggc 128400 gcatccggtt ttgaatgaag gttcgtccgc actgctgtgg gcagtgtaat tcaaaggggg 128460 ggggaggatt tttcaaattg gctggcttgc agtaaagtat caaacatgag ggaaacagca 128520 cagtgtgagt aggcttgaaa ccgaaaacag tgaaccccta gtctctgggg cttgtgtgaa 128580 tagaggcgta atagccacct cgctggtgtc agtggacgca cttgaccgtc ggagaacgaa 128640 actccctgtt gtagcgtgat tagctcagaa tcagagagca ccctgttggc aagtcgacac 128700 caacatataa ggggaggtcg ggggcgctaa tctccatcac gccgacaaca ttatgagtct 128760 tcatagaggg ttcataatgt tgcgtcaaag ggcaacacga ggattcctgt tggttggatt 128820 aacttgattc atagttcctg ctgattcttc ccggattcag aagagcaccg acaggacgag 128880 gccggatgcg taagttccgg caaatcgatg gtgaggtggt gcattggtga cacggggtag 128940 cgctcagaag tgtggttcga ttccgcaccc tcgccaacaa aataaaaggt tttatcaata 129000 acgggttaca aagtatagtt aactcactga acggcaagct gtttgagtcc tggccactca 129060 taacgatgtg agaccaagac aggtaggttt aggactcaaa caggttttcg ttctccagga 129120 ttataactgg gaaaactttg aagcgttgtc gtttgcattc caacatatca ggagtgcaaa 129180 tatgaaagag ttcagttgtg agcaggttcg tcactggttt gattatgatc cggatactgg 129240 cgaattgact tggaagaatc ctcgttcacg aagatgtcaa cctggtcaga aagtgggcag 129300 tgtctccaat gatggttatc ttgtcgttgg gttggcgggt aaacccagac ttgttcataa 129360 agttatttgg tattatatta ctggtcactg gccggagtat ccggaagaag taatagatca 129420 catcgaccga aacaggttga ataacaagtg gtcaaacttg agaattggaa ccgtcactga 129480 aaatgctcag aacaggtcta ccaataagaa ttcgagcact ggttgtaagg gtgtgtcctt 129540 cgataataag acaggaacat actacgtgca gaagcagaga aataatatac ggtttgttaa 129600 gcggtatatt agaactctgg aggaagcatg ccaaatctac acagtgttgt aaccgtggtt 129660 ttcgttttcg ttgtgcgtga ctttgcgggt ttttagaaac tgaccacaaa aaataatcgc 129720 taatgataac acgttcctgg cagtagctta acagccatac accagtgagg tcttccgatt 129780 cctcatcatc aaattcggcg cactaaaata gacgggaggg tgtgattaat aatctcccgt 129840 cgacgatgag cggagcaggt gcttaaacag gtttcaggcg tgagccagcc cctgatttgg 129900 ggagcaccct gggaggttcg attcctccct ccaatcccaa agccgttata tctgactgtc 129960 caaaggggat aagctcctga gtaagcagag gtgggttgcc taagtcagat gggatgtaag 130020 gtcagcgctg gccaagcatt tgggttcgac tccctaaaac ggctccacat cttagaggac 130080 attgacaggt ggaagcattt ggcgccaaat gctcgtggcg ggttcgagtc ccgtgcagtg 130140 tcctctaaga tgtgagcgaa gtcttaccaa ttaccctgat ctctggcaag tgaagggcaa 130200 cgcaaatcga agttctctgg gtatatcttt taaccctcaa ggtctgtaca cagaagtggc 130260 cgtcccatga gtaagttagg cgatatacaa catgttgggt cgaacctgtt aagcccagag 130320 aacttcgatt tgcgtacttg agagagcgtt gtatgaaata gggcaatgcc ttgcagacct 130380 cgacgcctac acattctaga cactggtggg cgctggcgaa gatctcaata taagctggtc 130440 atcaagggta gctccctgac tagacgaaca atgagaggcc gaactaaggg gaaacccgag 130500 acaggcgcag tattttcaag ttcgcaaaac agtgatcatc ctgacaagtg tgatcactct 130560 tcgatagaga cattacatcg tggctatcaa ccacatcctc gctctagtga tgagtggtgt 130620 catgtttctg tcggccagcc tcgtttggtc cgagcgatag aggacaagtg ctgaagcgag 130680 acgaagacgc tgaagtgcga gttgtgacat ttggttgcaa ctttgatggc tctggatttt 130740 ataaaccatg tctatgggtg acgcgggatc tttagtacca gagccatcaa agttgtgtcc 130800 aacccgatct tgcaagcccg tatccctgta tggtcaagac ttgcaagtgg aaagccctgg 130860 aaaaataaac gcctgtggtg aggctacggt gcaagccaaa gacccacaga agcgcgttgc 130920 cgtgaggcgc acaaacaggc atgcatgaac tgatcatgca caaacgggat aaagggttga 130980 gagaccttgg ttggacacaa catacaatta atccataacg ggagaagcaa tatgacttgg 131040 cgacagcgcg gatacaaaac cgtagaattg atttaaaatt gccggcgccc tggttgagtg 131100 agagatcact gccgaaacca ggaggaatgt gggagggtaa ataccctccc acagaccaag 131160 aacatatatg tttgtgtatt tttgtgcata aacatatatg gtcctgtagc tcagtggtta 131220 gagcagtcga ctcataatcg attggtcatt ggttcaaacc caatcaggat caccatatta 131280 aggggcgata gtttaaggga tagctgtccg gacggcgagt ccccagagag aacagctgga 131340 ggccaatcca gcaggtgagg tgaaaagcct cagaccccgc caatatttgt tggactgcca 131400 acaagctctg gtctacggca ggcgagatgg ggtcgcggga ttaaaatacc gcctcgggag 131460 cacctaaata aaccagttgt tcaataaaca attggtgagt atgatgaaaa cgttcggtga 131520 ttttcttact gagtgggatg gtctcgctac cgacaacaaa gagattgttg agtttgttga 131580 aaagcgaggc gataagtggg ttgtccttga ccacaccaag actaaagttc ttgggacaca 131640 tgacaccaaa gctgacgcgg acgcccaatt aagggcgatc gaagcgaata aacatagttg 131700 aagggttcta tattatgaag aatatttggg tggtgatttc caacagaatt cgcgctagtt 131760 gggaaggtcg gatggtgagc atcaagaacg ggtctcatcc aaaaacttac gatcgttatg 131820 atcctgccct gggtcttcat gcagaataaa gaatgtttat acgaaagtaa gaatagagac 131880 gatgtagttc agtcggtaga acggtggact gttaatccat atgtcgcagg ttcaagtcct 131940 gccatcgtcg ccaaattgaa gtagagtatc tcgaagcgcc ttcggaagtg cgaatcgcgc 132000 gatagctgcc aatgtaaggc tgcaggatac agatacccag gggagtgaga cctacttcat 132060 acgatttcag agtgtagagg ctacagtagt gcgcacctca cggaaagcta caccggacac 132120 tctgatacaa aatctaccac cgcgtggatt agctgaggaa ggatggccga tgtcctcaag 132180 cgtggcccag cacgtggtgg tagaccaaac acagtaagcg ttgcagccag ctgtgtataa 132240 aatggggtga ctccacatcg gaaacgatgc cccaacttcc agaaatggtc gggcgtgaag 132300 cctgtaaagt tccaggagat cagaccagaa ggcactggtc gccttgttaa ccaatcgacg 132360 cttcggcgtg gggagttgga caggcagatg aaatgctcaa tcgggtgtga agcccgtcca 132420 tattacgctc ggtcaagcag tctgtttgta gacggtcggt gcgggttttg caagactcgt 132480 ttaggctaac aaatggatga ggcgcgactc tctgggttga tcaccagagt gctggggttc 132540 aaatcctcta acgagcacca aacaacgtga gtgtggcaga gcggtcgaat gcaggagact 132600 gtaaatctcc ccgtaacagc gcggtggttc aaatccatcc actcacacca aatttgcgat 132660 catcgcggaa atcccagacg cgagtggatg ccagggcgga agactggcac atgggcaccg 132720 acggcaaagg tgctctaact cctggaattg ggtggcctga atggtaggga aagcgagcca 132780 agcgttgtgg gttcaactcc cactcaccca gccccagatg gaatgggtcc atcatcgcaa 132840 atcaaattat gagtgtgact tcctgaagat gaagaaggtg tgcatgccga cttcataaca 132900 atctggggtt aaggaagtta agaaagtcgc aggatatgca agtgaaatgc aaatagcttt 132960 cagcgtcctg acgatttcgg gttcgattcc cgacgcactc tcccaaacgc ctaatactag 133020 aaattgctgt gagtagtctt tccatcccca cgatggttta accatagccc gatcaggaag 133080 atcgggcttc tttttgtcta taataaatag atctgacttg taaaggaggt ctattatggc 133140 aactgctaag atcataccaa acgcaagtac atggacacaa gtctcagacg gaacatcttt 133200 gaaaactctt caagtgactc acggttctgt gtatttgtgc gatagcccta gtattccaac 133260 gggtaacaac gcgcacatca tatatcaagg aaatatggtc gttttaaccc cgccgacggt 133320 gggttgggtt aaggcaatta attctgatgc gacagttatc gtttcttaag ggggagatat 133380 ggctattttg acatctccct atttggggaa tatgcttcag acccaccgca ttaaaacaga 133440 agtcagattt tctggattgt cacaactgct aacttctggg gcaactggaa tagatttatt 133500 aaccgtgttg gatgggaaga ctccgaaccc ttcttctcct actggtttag ccccgttttt 133560 taaattatca gatcacaaat ttcatgcgtt tccctatgat tctattcttc cggtgaaggt 133620 taatattgtc ggatcatggt ctgggtctac ttctaataga actatgatat tagattttgt 133680 gggttctgtg gggaaccagt tatcaagaag tcgtgatgct agcgtaccgc cgccggacac 133740 tttgtctttc attacattct tcagcgttga caaggatggg aacctggcga ccaacggagc 133800 gcaaatgaaa ctgtactctt atggtggtga ctttacaatt accgaggtcg tgttgatcgc 133860 tgagcaggtt gtcccactct atatgactag tatttgattt gttcaatgag aataaggggt 133920 ttaaaattta accgtttata aaccccttca ttgatttgag gaaacaacat gcgtaatgtt 133980 acgatttggg attacaacga tgtcgtttgt gacctgcctc catttgctcg cctgtacaca 134040 tacaaaggga acaaacgtac tctgaatgag ttcttgtatc cggcatatat ctatcgggac 134100 gggcatcttg ctccgcgatc acttgaagaa actggtgtgt gtactccttt tgatatcaac 134160 aagaaagggc aagcggtatt cattggttat tccagcgaag acgacatggt aaatggtcga 134220 cgcggtctgt atatggtgtt caatacattt gagcaagccg tgaattggtt attcaaaaat 134280 ggttatgatt tctatggtga agagagttct actgctcgcc gccgtaaagt aaagaatgtt 134340 gatttctacg cagagcgcaa gaaatatctg gatatcgctc atcaatatga gcaatctaag 134400 aaatccgttc taatcaaacc atgcgttacg gtcggtgaag aagtgagtgt cgtggacaat 134460 tcctatttgg atcaggcaat taaatctttg aagccaactc ctctggccag tggtgctccg 134520 gttgttaaac atgacagttc aatcccgaca ccgcctactc ctccggccag tcgtgttctg 134580 aatgatcagg gcgctccggt aaaacaaaag gtcgagaagc cgactttcat ggataacatg 134640 atgaagttcc ttcgtctgtt caagaagtaa tccgagattc tccttttcta tactcctgta 134700 gatacgctat gataagccaa tgtctacagg agaaatagaa tgaacaaaac catcttcgat 134760 actctttccc tcaaccgcga tctggttcat tgggaagatt atctctacaa acacaccccg 134820 tgcgaactta ttgccaatcc agaaaccaat cagcaggttt ggttcaaacg tgaagattac 134880 ttcgcgcctt tgtcatgcta tatgaatggc aagcaaggga tcaatggcag caaactccgt 134940 caggccatct ggctcatgat ggagcatctt aaagcgggag gatccccaga tcttatccat 135000 ggtactgtcg ttggtagtcc gcagtcccct atggcgacgg cagtctcacg gcatttcggc 135060 ggcaagacaa ccactgtgct gggtgccact aaaccaacca catgcatgaa tcatgatatg 135120 gtttcaatgt cagcatggtt tggtagtgag ttcaactttg ttggatctgg ttacaatagc 135180 accattcagc cgcgctgtaa gaaactcatt gaacaattaa atccaaaggc gtattatctg 135240 gaatatggca ttacattgga tcataccgtt cattcaccag aacgcattgc tggattccat 135300 atgctgggtg gtgagcaggt tgccaatatc ccagaccata tcactgatct gatcattcct 135360 gctggttctt gtaattcatg caccagtatc ctgacaggtt tggcgatgca tccgaaacca 135420 aatctgaaga atgtctatct gatcgggatt ggcccaaacc gattagattt cattgaaaat 135480 cgtttgcgca ttatcggtaa acaagcaaac ctccctcaca taactgattt cactcgtcgc 135540 tatcacgaca acccagatta tgtgtatggt aagaaggatc tccagcatgc ctctaagagc 135600 gtttcgctgg ctggcctcct aagtggtatc aggccaaaga acgagccgga tatcgtgctt 135660 cctcgttttg aggtacacca ttgggatctt cataccacta attgggttcg ttacaacgac 135720 ctcatggatt accagtgggg agatattgag ttgcaccctc gttatgaagg gaaggtgatg 135780 acatggatac aggaacacaa accagaattg cttaatgaga actcattgtt ttggatcgtg 135840 ggtagcaagc catatctgga agcgatgaaa gctgcttgtc ctgaattatc aatacctgaa 135900 catgtccctg tgaatgagtt tgtccccagc taatccatcc taaatacccc atacgaccag 135960 tgtggggtat ctatgaaaac ctttctagaa ttttatcgcg aatcaacgtt acctgatttt 136020 acgaatatcg ttttgtatca tgggtctaat gttgaattcg atatctttga ttttgaaaaa 136080 tttggccaga ctgactctgg tacgatgggt gctgggtttt acctgacggg ggatccagaa 136140 aaggcacaga tctacgcaga aaatgccgtg cgctatcgtc aatctggtga acctattgtc 136200 gtggcatttc gtgtcaaggc caagaagact cttgtaatag attccaacaa tgtttcggtg 136260 tgggaaaata aaatgcgtga gttggggata aagcctggta agatacatga taatgtgaaa 136320 gaacttatca acaaagggtt cgattccata gcctctatga gtgccaataa cgttgaggaa 136380 atggtggtgt ttaagccagg gttggcgacc agagaagcct aaatagtcca aagcggttta 136440 ttcaagagga cattaccatg ccaatttcga aattatttga agcggattcc ccagcagaca 136500 tgcctatctg gactggtgtt caagacggga ctacgattga attctttgag cgcggggaaa 136560 caggcgctga agagatttat gcttccgtgc aagggacaga cgtcgtccgc gccgccgtag 136620 ctcttgctac atttttagag gacgccccga ttgacggtat cccgtttgaa gcccatgtgg 136680 acccagaaga cccgacgtct atcatcatta cagtccaggg tgctgaatat acatcttaca 136740 gtattgagca cgatgaagaa acaggggcgc tgtttatagc cacggatctt cagttggatg 136800 atgaagagat cgaatacctg aagcaaaatg gacgtctccc tgaatattct gatgaagaat 136860 tggattcagc gtttgacaac gtagacgatg atgacgactt ttgggatggg aaataaacaa 136920 aggggcttaa tgcccctttg ttttagatat cgtttgtgtg tactgtgaat ctcattgtta 136980 cgacatctgt tctttcatcc ttgtgtaatt cgaacttcaa accttccttc agaagactcg 137040 ccgccaacaa tgttttgaac ttttcgactt gcttgtctgt tgggtatttt tgagacttat 137100 atgcctgttc aaatgctgtt aatatttcgt caaacctgtg gccaccaaca gcgtacacca 137160 tgtcatcaat ttcaactccg cgatttgctt gggaaacgag ttgcttcttc attttgcaaa 137220 caaagatatc aacggctttt tcaactatcc ccatggcttc ccaaatctga gcctggtcaa 137280 tcgtagtctg taattcttgt gcgaagtttt tcatcatttc accttcctcg ttggatattg 137340 gttaaagagt ttgcccagct tggacacatt gataatcgtc tgagtcttcc agcgctcgat 137400 cccctctggt gtagtcacgg ttaggattga ataaccccat atatgggaac cattcagcac 137460 agccgcgctg tgcccaccaa ttttgtcttc cagtttacaa atgaaagact catattgcat 137520 cgcagcgttt cgacgtgctt ctttgacaaa cagagcatgg cgctcaggat cagctttgac 137580 aatatccggc ttcccaggta tgtaagaagg attcactgcc tgggtcaaag aacggtagag 137640 cgcatgtttt gatttcattc gttggtaatc tggatcacca aacttgacac caaccgaaga 137700 tggccacgga gcgcacttct cgacgtccca gccgttggat gccagatcgt ccattatgtt 137760 cttgatgact ttgttcgcgt actgctcagc agcattctca gcatcaacca gcagaggctc 137820 gacggcaata cggacaggag tttttggggt gctcatgata tagtccttca ttcagacaga 137880 agacgggcgc ggacataacc caggatgtac gaaaccatac cgtacagcag gacagtcagg 137940 tcactgggga ttaggtgata cttgccgatg tcggccatgg ccagaaatgc gaatactacc 138000 cacacgataa aaatcataat atagtccttc agttcaaagt aagcccccga aggggctttg 138060 tcatattaga ggcgggaatc caaccatgcg ttcttttcat tctgccattc ccaagcggcc 138120 tgaccaccag ccatgataac ttccagagaa ggagtattgt catcctcgcc gccgtgaaga 138180 tctggatcaa atccatcatc ttccggatca tcttcacatt cgttctgata tgcggaatat 138240 tcaatataat gcgcttcggc ttcgtaatcc atgtctccca gagcagtctc aagagtcatt 138300 ttaccttcgg caatcagctc agccgttgcg tcgtccagac ctgcgtcttt cgcttcaacg 138360 aacagttcgt gacgtttctg gaagaaaaag aattgcatgg cggcagaacg tgaatcaaag 138420 aattcttgac gaggagcagt gatatcacgc ccatcaattt tacttaccat cacgacacga 138480 gaaccgtact caaccaggaa gcgaccgcct tttacggggt tgctgccgtc aactgtgccc 138540 aaagtggtga ttacacggcc ttcttcggtg ccgaacaata cagttttgcc ggatttggat 138600 tgagcgataa tttcgattgc catgatgtat ttccttctct tcagattgtt gtttgttcgt 138660 actacaatta gaagtatacg ccagttattg aagaagtaaa ctttattcaa taaatatttt 138720 aataaatttt gaactctgct cctttgtaca ctgctgtccc tcgttctatg aggccgtcgg 138780 ggacaccac ctttgtgggc catccgccgt ccggtgcttt gacagtcagg cgtgtcttat 138840 gatcacccag ctgaatctgt tcgtaaatcc ttcctctcac tatcgtcgcc ccgccttggg 138900 tgacgagcaa tctcttgttt accactttca ttccttaaca ccaaaagaaa ggggagtttc 138960 ctcccctcta acttatttct tcagatcagg ccacgcacca gaggtcgcag tagacccagc 139020 tgggggagca gactcaagat cgggagaacc cgactgagta acaacagtgg gatctttgtt 139080 aaccactttg accccaaact gcttgagagc atccacagct tgcgccttcc ggctgttgct 139140 tttgtaatgg ttatacccct tgataccgaa tgatgcacta attgctgtca ataacgaata 139200 ggtataccat tcaggtgcgg tatcgagcgc ctggaggccg ccgattactg ctttgatgaa 139260 atccccttta tgatactcat cagggaacag aattagttcc acaaccggag cagtcatgac 139320 gaggatagcg ggtacggcca acacgatagt ccagaattcg tctttccaag acccgccgac 139380 ttcggtgatc ttagacagct cccaatctga ggaggacttg atagcctcca gcttgacatc 139440 gtgtttggcc tgaacaactt cccgcttgta ttggatcaaa tcagtcccga ggttccagag 139500 ttgcttgagc gcccctggga tcatactcac aaaggggatt gccataataa actccttggt 139560 cattgaacgt tcctcggcta aattacgggg acgtgctaac ggcacggtta accggagaca 139620 aacaatgact gttttctata cgaacgttgc ccgacagggt aacgaccttc tgattcgtat 139680 tgcagacgac aacggcaatc gccgtatgtt gcgtaagaaa ttcgaaccca ccttgtattt 139740 acccacagcc gattattcca aagttgaaaa gattggcctc ctcaatgaac cgttggtgtc 139800 taaaaaattt gcgtcaatgc gtgacgccga caactatctg gaggaatata aggaggtcga 139860 aggcgctgcc gtttacggac aaacggatta tgcatatcaa ttcatagcgc atagttttcc 139920 tgggatgatt acccccgatt actcaaatat tcacatcgcc aacgtggata tcgaagtttt 139980 ctcggctggg tggcgcgatg gagaaatgac taaaggccca tttcctcacg cgacgattga 140040 atcccacacg tttaagggga gcgaggcgcg tgttcgccga ttccataagc aagtgttggc 140100 caaccatgat ttcgttcgag agcacttccc aggttccttt atttccaaca acgtgactga 140160 ccagttccct atcattgata gtaatggtaa gatcacacag aacatgaatg cagccttccc 140220 tattacgctc atccagcttc aagacatgaa taccaacaag ttctatgtct ggggtatgcc 140280 gtgctctaag gatcgccata aattcaaata tgatccaaat gatgaagaga taggtggtct 140340 tgaggttgaa tacaaagaat acacgactga acaagaactt cttcgcgcct tcttagatta 140400 ttggtctgaa cgtcaatttg atggttggac tggctggaac atcgaaacgt ttgatagccc 140460 gtacttggtt gaacgtatta cgcaggttct cggcgaaacc caggcagagc gcctcagtcc 140520 ttggggcaaa ctcaagaaac gtttcatcaa agaccgtaaa ggcgacgtga cttcttatca 140580 attcgtgggt tgtcctatga tggactacat gcaagtttac aagaaacaca cgtacacaac 140640 ccgcgaaaaa tactcactgg attggatcgc ttattgtgaa ctcggtgaga agaagttgga 140700 ttatagtgaa agcaagtcat tgtatgatct atattttaat gattattgca aacacacccg 140760 atatggtatc aaagacgtca aactcgtgtg gcgtttagaa caaaagctgc gtttgataca 140820 gttgatgttc gtattggcgt atcgcaccaa atctaactat gaagacggtc tggggactgt 140880 agcaccatgg ctggcgatgt gttactatcg tctttatgaa aaagggattg tccctaaaat 140940 acagcgtgta tatgatggtc caacggactt tgaaggcgca tatgtcatgg aggttgcacc 141000 agggatatat ttctgggtat tctctgagga cttaaactcc ctgtatcccc acatcataca 141060 gcaatacaac cttggtcctg agactatcgt ttctgacaag cacacacgtc gcgatatcat 141120 tgagtccatg tgtgaggaat taaccaaagc gatgaatgat atgacaacgc ctatgaacaa 141180 gcgccgtcat ctcaaaaatc ttcatgacaa gctgcagcgt gctattgatg aacgcataca 141240 agttgttgat gaattggtcg cgctgggtga attccatttt gaaacgttac gccgttataa 141300 cgtttctttt accccgaacg ttcagttctt cagtaatgag aagatgtcct tcctttccga 141360 aattatgcga ggcatatacg ctgaccgtaa aggcgagaaa gcaactggcc tgaagtatga 141420 gcaatgggct ggttggtgta aggaaatgtc taaaggtgat ttccaccttg aatctgccat 141480 gaagtctcgt ttctacgatc ctgaatggta tgaagaacac aagcatatcg accttgatca 141540 cctgactgaa gtcatgcata agtgggaaga tttgggagtt gcccaagata cgttacaaca 141600 aggtctgaag atcttgatga acgcaggata tggcgcaatt tctaacgtct ggtttaaaga 141660 atacttcaac atcaacatcg ctgaagcaat taccacttcc ggccagctga tcaataaatg 141720 gaacaaacgc cacactgatg attatctgaa caaactttgt ggtactactg gtcaggattt 141780 tgttatcgcg ggtgatactg actccaacta catttgcatt gaacgcctgg tcaagcaatt 141840 atggcctgat gaaaaggatc atcataaact tgttgataac atcgaccaat ggatcaaaga 141900 gaattaccag ccaaaaacca gtgaatgggc gcagttgttg tgtaatacca tgaacgggtt 141960 tgagcagcgc atggtctggg aacgtgaggt catcgcatcg tctgctgtat ggcgagccaa 142020 gaagatgtat tgcatggcag tatacgatag cgaaggcatc aagtatgaga aaccaaagat 142080 caaattcaaa ggtctggaag cgcgtaaatc tacaacgccg gaatggtgtc gtgagcgtct 142140 ggttaaatgc tatgagaaag tcctgctggg gacggaggct gaagttcagg aattgatcgc 142200 gggttataag aaggaatata tggaattaac cgtggatgat attgctcaag cctctggcgt 142260 tagtgatatt gagaagtggt tagacgcgaa cgggaattat atcagcggta cacactttgc 142320 tgccaaggct tgtattatgt acaacaagct gatcgataag cacgaagatc tcggtcttcc 142380 ccctatcgaa tccggtgata aggttaaaat catcaacctg aaacctggca atcctgtggg 142440 gaatgatcgc atagccttcc ctgacttcct tcctccagaa ttgggattgg ataaatgggt 142500 ggattaccac accacgtttg aaaagacctt catagagcca attcagtcta tcttggatgt 142560 ggttggttgg tctcataaac gtcgagttaa tctgttgtcc atgatgggca agaaaggttg 142620 attcaataaa ccaaaggggg atataattcc ccctgttatc cctttgacaa caggtattgt 142680 tatgaaactc aataagattc ttctggtgtg tgctctggct ttctctacca ctgcatgctc 142740 tacccttctg gacgttgcgt ctactgttga cctcgatgcg ccgacgttca ccaatcagca 142800 agcggtgaat aagatggaag acaccatcaa ggcacatgca gctttggaca acaccactcc 142860 tggtccgttg caaactgttt gcaattatga tgattccatc caggaagatg aaacctatca 142920 ctgcaccact tacgtgaagg aatcttctgt ggttctgtat gcagattgca cagaagagca 142980 atgcaccgca actggttatg atcaagtgga gaagtctgat gaataatcat gttggtctgt 143040 atgatgccaa ttctaaaatc ggtggaatgt atcgtatcct ggtagacgta gacttgactt 143100 tggttgatag cctctcccct tgggtggatt ggtttaatat ttccaattca aaagctgctg 143160 ctgaaaacat gggttgccat gattatccca atgatttcca gcgtatcacc aaagagtgct 143220 atatggctca tgctggtgat ttggcgatcc tcatgcggga acgcgctcac ccagcatggt 143280 tgacacgccg tgtgtttgtt gctggtcaat ggatggattc acctacagga cgtgatccta 143340 tggattggtg gcgcatgccg gacctgtatg ccaagatgaa cccgcttcca ggtgcttacg 143400 agttcctggt gaatctgaag aagatcctac tcgaagactt tgaaaatgtt gaattgatcg 143460 cagtatctaa gtgtgagcca gaacacgagc gcagcaagcg ccagtttgtc tatgacaagt 143520 tccctggcat cttcaacggg tttgtcagca ccgacgaaaa gcatcttttg gcaggtgatg 143580 ttttaattga tgataacccg aaatacgttg aaccctgtgc gatgaacaat atttttgtca 143640 tctttgttcc tcagggaaat tatgaaaaac tggatctttc gaactcggaa gatatgcttt 143700 atattaaacc agtagaaggc cagaaccact tcgacttcct gaaccgtaat attgtcgaag 143760 tggtgaatcg cctgattggc cattatcaat acgtccgttg aggaggacat cgtgcaagaa 143820 caatctaagt ttggggaaac cccagacaag cgttccggtg atagcgatat ggatggcgtt 143880 attatccatg tgaacaactt cattcgtaaa caaaccacac ccacttccgt tggtgcggcg 143940 ctggagttaa agcgtgttct gatagaaaac ggtatggcac cagatgacga tgaaattttc 144000 tataactttg aagaccagta taaagtgaag tttgtagaaa acgaacgtcc acaggttgct 144060 gttttctggt ctccctggtt gggcggtgtg agctggcgta ttgaggaaga tgcataatgg 144120 ctaaaataat tgtagtgaaa ggaacatctg gcacgggtaa aggcacccgt gttgttcagt 144180 tcatcgaatg gctccgcact aagctggagc ctactgaact cacctacacc attggtgaca 144240 agacgcgccc attcggcctg aaattcgaag agctgaagtt aatcttcgtc ggccagtata 144300 ccgtgtccaa caaatccggt ctggcttcct ggacttccat ggacgccatc cacgccgcca 144360 caggctcggg tgatatcgcc cgtgatctgg tcaaaggctg gctggctcag ggttacactt 144420 tggtgtgcga gggtgaaccc ctcatgctgt cagataaatg gcgtcctgaa tggatgttca 144480 agaactatcc gattgaatct ctggcgttgc tttattttgc atacccagac cgctatcagt 144540 atgatgcgcg catccgtggt cgctctggta aggaagcagg ggactccggc tggtcacgca 144600 acgaatctta ctccaaagag tttgagaagt cgaaagctga aatgctggtg ctgggttggg 144660 aagtggtggt caatgactac agcgggcaag acgtgttgta tcgccaatcg tctacaaaca 144720 ctcaagaatt caaaacagga aatgatagcg aattagccat gatgccgttt gatgcacctt 144780 tgtgggtgat tggcaacgct attcatcatc aaatgcgtgg tgagtttcac gccatgggtc 144840 tggacatcaa agatttctac ggattctgtg aaactgaccc aatgacgcgt gaagtcggtg 144900 gggatgatcc tctagcgcat cgagtccctg agaaggcgac caaatctaaa accaaggcga 144960 gcgccaaggg agaggtaaca aagtcctctg tatcccttct cggcctgttg agtaagggtt 145020 agaaatgaaa cagatgtcta aatattttgt gttcgtcgga ttggtgatgt gtatcacagc 145080 tgtgcttgtc ggtgtcatga aatatttggg catcgttgag ttggattcaa ccgaaatatt 145140 gaacgtttac gcgttatatt atttgggggg tgctatctta ttaacgcctt tcgtctataa 145200 cataattcag agtttcaaaa ggaattaaaa tgaaaatcct cattccacgc aacgttgtcg 145260 ctgttgctat tgattaccgt ggtgatgcga agatgattaa cgctgtccgt tattatccgg 145320 aacagaataa aatcgtccca caatttcaac tgaataccaa tccttcttct aaggatttcg 145380 gttcttggcg tcaggtgggt ttggctcgta cccaagtcaa tgcccagcat tttatttccg 145440 aaaagacgaa aaccgccaag caaatttggt tggtgacgaa tgatcgtcgt ttcctgccta 145500 tctggtctct gggacagccc gtagtaagcc ccgaagaaat tcatctggct cccgaagctg 145560 agcctgaagt tgtttctcct gtagaggaag cgaaagatga aaatcaagca ggttgatttt 145620 atcttcatga tgttgatgtt cgttatcttt acggtttcgc tggtcggcgt catggtcaca 145680 gaaggggtgc aacagcgccc attcttggtg atctgtccag tatcgatcgc cactttcttc 145740 tatctggcgt tccgtgttga actcgggagt aaaatcggat gatacacatt tctaaaatgc 145800 cgcagggata taaagcccct gaaaaatgga aatacccgat tgatctggca gtagattatc 145860 gtaagccaga aaatcgcatg tacctgctca aggcatgggt ggaggcgcta tcctacactg 145920 aagagcataa ccagcaagtc cgtctgatgg attatgccat cgaggttaca gaaggcatca 145980 cacagctcga aaagatcgag cgcaagattt ggatggcctt tttgtggggg tgttgctata 146040 atgggattgg accatggaca atttacagtg aatttcctgt acccccacaa tctccgaaag 146100 agtttcagcg attttctgat tggtataacc tgaactttga tcgtatgcgc ttcgatacag 146160 attgtcgtta tcgtaagtcg aaaatgattc cgtgcgttca gtcctatatc gattggttgg 146220 gtggtaaaac ccaaatggat tcttttcgtt ggatgttgga atgcactacc aaggaagacc 146280 agttcaccga actgtggaat acggcgatgt catggaaata cttcggtcgc ctgagcgcct 146340 ggaacttcct ggaagccctg aacatggtct tcggtaacat atgggatata gacgtccctg 146400 ggttcatgtt gcgtgaccgt gatggtagcg aatccaatcg taacggcgcg gcgttcttat 146460 ccaaccgtga tgattgggtg accaagcacg ggaagaaaaa gattaacggt tgtcctatta 146520 cagacgaaga atgtgatata ctcgaaaccg accttgagaa agcgtttcag gaatgcgttg 146580 aagagtttgg ccacatcacg tttatcaatc gtctgaactt tgagacctcc ggtgcttgtt 146640 ggctgaagaa attcttccga ctgaagaata cccgttacat cgggtgggac gccgagcgta 146700 catgggacga gatcgattat atggaacgta tttggcctga atactcctgt gcacctctct 146760 gggaagcccg ttcactctgg ctaccagata ccctgttatg tgagaaagct cctgcagggc 146820 acgttccagg cgtccagaag tggaagatgc ctgtgttctt tgagacgggt gttcctctac 146880 atatctggca tttacagcag ggcacacgtt gggaaccgtc tgaggtttgt ttgtcagttg 146940 gtaaattgga caccatgagc cgaaatggta ctgtgtatcc ttctaaaagt gtgaacctca 147000 tgacactctt gaaacgctga tataaatatc ctcgctataa agtgaggata ttatcatgtt 147060 acaagatctg ctggtttatg cgcttcctgg tgtggttgtt ggcttcatcg ctggcgctct 147120 ggtcttccgt aaacacgcgc aagacggtga agtgattgtt cagaagggta aagacatcct 147180 ggaacaaatc gaagccaaac tggacgagct gaagaaaaag taatctgatt gcgattgcgt 147240 tcttcaataa aggggaatgg gttattatta gcccgttccc ctttcttttt gcaaggattg 147300 attttatgac acctcaatac aaaatattgg tcaccagccg ttgttatgct tatggacagg 147360 gtgaagcaat atcagtacac acagttgtag ttgattttga aaacaaagaa caagcagatt 147420 tggcattcta caatatgcag cagagcacag ctcctgccga tattggcgtt aaacaagttt 147480 atacgaaatt atactgaggt cctatatcat ggcaatgcaa cgaattgaag acatgtctgt 147540 gctcgatatg gaagcgacat ttggcgacta ttttgaatct accccgaaac aagaaaaagg 147600 tcatctggta gtgtcggaag agttcgcaca aaaagttcaa gatacgcttc cgactaaatt 147660 gaacggtggg caaggcggtt tccgtcgcgg tgaactgaat atcatctgtg ccggagggat 147720 tacgagatga agcgccccga atacaaacaa tatttgtacg atctgttcat gaaagaaacg 147780 ggggtgcgc tccaccctaa gaaagcgact attgttaaat tgcattctga aggtgatttg 147840 tctatagcat atatccgaaa agaactagat ttgatgggaa tcgaatatga agaccatatc 147900 acggatacac gtgctttaaa aagagcaaca gcaatcgttc ttcataccgt tgcaacaatt 147960 atgcatcgcc accatgtttc ttttgacgat gcaatgactc cacagtatca tgaagaacgt 148020 tgggatctgt tgttgaaaaa tggggctaaa tctgagcata aaaatcaact tcttggtatg 148080 acgaaggaac aactcgtgga tggtgtgtta tgatttacct tctgtttgtg gttcctgtaa 148140 ttttggccat cttgtttgtg atatatcacc gaaagactca tgagccaaag gagactttga 148200 tcgccacggc cattgttatc gtattatctt gccttatcca gtcgggatta tatgctgctt 148260 tctcccttgg tagttctggg gacgtggaaa tcctgaatgg atatgtaact gataagcaac 148320 ggaataaggt gggttgtgaa cattcttatg aatgtatgtg ttattacaca acatcttgta 148380 caggttcagg aaataaccga tcttgtacac aaacgcgtca ttgcagcaca tgctatgagc 148440 actcttatga cgttgattgg gacgtattaa caaccgtcgg tgatctgagc attgaccgta 148500 ttgatcgtca gggtactaca gagcctccgc gttgggcaca agttaaaatc ggggaacctg 148560 cggcacgtga acattcatat atgaattatg tgctgggcaa caaagattca ttattctcta 148620 aatctgacca gcaattcgct gagaagttca aagagcatat cccttcatat ccgagggtgt 148680 atgattatta ccgagtaact cgtgttctga atatgtcagg gatggacatt cctgttgatt 148740 actggaatga ctatctgaac aatactctga aaacattagg tgcttcacgt caggttaata 148800 tcgtttgggt tgtgacttct ggccagcctg ttgaatattt tcagggactt ctatatgcat 148860 ggtccggcgg taaaaagaat gatgttattg tagtcaccga tatttcaaag gatatgaaaa 148920 ttaattgggg taagtctacg tcatttgccg acggcatgaa caacatggaa ctccattctc 148980 gtaacggact ttcattgact gggaaaccaa tgggcatatc cgtgttccaa gaagttgcgg 149040 tcaatatcag taagggatac aaccgagttg agatgaagga aatggaatat ctgaaatggc 149100 gagatcttaa aacttgggaa gtgattatcg tcgtgctgtt tggatgtatc ccatttaccg 149160 cagttttcat attaggccgc atgcagtaca atggtcgaac ttataaacgt ttgttttaac 149220 aagaggaagt aaagatgtcg cagcgtaaag gtatttcaat tggttggatc gttgggttgg 149280 caattctagc atttgctgta attgggattg gcagtgtggt tagctatttc aatgatttca 149340 accgcattga acaacaggtc aaaaagttca acaaagattc tgaaaaccac ctgagcaact 149400 acacgctcaa agttcaggag acggcgcaga ttcctgacat gtacaaaaac agtttgaagg 149460 aagtgatcaa agatactttc caaggccgtt atggcgcaga cggttctaaa gcagtaatgc 149520 aatggattca ggaacagaat attcagtttg attcatcttt gtacaaagag attcaggttg 149580 ttatcagctc aggtcgggat gaattccgca ttagccaaac taaaaaattg gacgcatgtg 149640 cgatctatga aactaaactt ggccagttcc ctggttctct gatagcagga atctttggat 149700 atccgcgtat cgatcttgac aagacatgtc aggtggtgag tgacacccgt acccaggccg 149760 catttgactc cggtgtccag actccgatta acttcaaagg ctgatcttat gagcgtgaaa 149820 ctaaccgaat ctctgacgct ggaacagcaa caggcgttgc tggatgaagt ggtaatctct 149880 gctgtcaagc agggcattat caaagatgac acgttgttga cgcgccccga aatgatccat 149940 catttggtgg tgtgtctggg cgaagccaat aatcctcgca aaaagattgt aatgttcaaa 150000 gaaggcatta tttatcccaa tggaagattc gcttggttaa ccctatcggg aagtcatccg 150060 gatttgaagg atgaacagaa agaaatcaaa acttctgttc cggtaacgcc atacaccgaa 150120 ggagttgatt tattgtcttg gtttgagact atcaatacca tctatgtcat ggcacctgat 150180 ggtaagccag cacaggatct gcgtggtggg gttgtaggtt cggaagacta atcgttcttc 150240 aataaagggg gatagggtat tattgctcta tcctcttttt tatggaatgt attatgtctg 150300 acaagccaag aaagattgca attattggag gaggaatcgg cgctcggact atggccatta 150360 tccttcaaga aaagctgaaa ggcgttgaag tagaatgtat cagtgtagac gatattccta 150420 aacgtcgttg tgaaccaggt gaacgcatga taatttgtga tgatctggta gaaagtgaac 150480 gcaaaacatt ggtatctcaa gcggtggctc agttacggaa ggcagatatt tcgtattgtg 150540 aagcagaagc cgatgacagg gacataattg cgtcacaacg ttatcaaaag ccgccgcgcc 150600 tatatggagc cgcccaacat aaacgtcagg ctaagaaata taaaaatcgg agtaaacgaa 150660 aatgactact caaaaaccga cttatgagga attggcacag accgttctga ccttcgaccg 150720 taccctgaag accctgtaca aggtactagg aaagaacccg acttcagagt caggcgaagc 150780 agttgatctt ctgttcctgc ccaactgcat ggtatcagct aacgccattg ttgccgctct 150840 gaaagataca ggagcgcgag agccggagcc cacagggatt cagaattatc tggagaactt 150900 tgacgagtac tccttcactg atctgctcct gcgcgatctg atcaacacag aacgtcgccg 150960 tcaggaaaag aactgccctg tagttcagtc tgaccatgaa atcgaacaaa ccgtccgtga 151020 agaactgaat ggcacctact cgcccatcga cctggctgtt atgatcgtaa aagctctgtc 151080 gtatgcagca aaaggagaaa caaatgtcta aaccattatc tgctgcggct gtagcaaccc 151140 ttgctttgtc cgccatggct gaagatatga cgcataatgg tcgtctctgg gatgatcatc 151200 gttatgcaca agggtgtacc cctggggaac ctgggcatgc tcgtccttcc gtcagtcgtc 151260 ctaaaaaggc caagacccat ggaaagaaca aaaagaaacg ccgtaaatga tgtcatcccc 151320 gaatatcgcc ttcacgcatt atcggaaggt gaacccagat catcacgatg tcatgttatg 151380 tttcaagaag gtaaaatgat ggccgatgaa atcctcttcc ttcgagcaga ggtgatccgt 151440 ttaagtaaca ataaaccccc aaagaaatga ggatatgtca tgagttctat tgaacagctg 151500 atcacaccac aatatgttta cagcaatatt gtagagcacc tccgctctca attgaatgtg 151560 aagcagttga acagctctga attgagtggt ttagaaataa cagaagttga agttgcggcc 151620 ttcggtagtc gttatcattt tgttgtcaat cacactcagg ttgaacaagt cacttcgagc 151680 attattgacc tcggcgcaac gaagccttcc cgcgcagagc cgaaatctgt gacacgcaat 151740 attgtgggtt atctggaaga gacgttagag ccaggtgcca cccacccgat attcaatttc 151800 aacgccaccg ttgtaaacgt tcagggaagt taatcctgat taaagcctcc gattggaggc 151860 ttttctattg agccacccgc cagtatcata accttaccca ataatgtgtt cttctttgat 151920 ctgaacagga attctatact atgaaatgc gcaagtccga gcatttcgtg cgctcttctt 151980 ctaccatcgt cggacagaca ttcaatgtca agatgacgga taaattattt gaaacattat 152040 tttcaagtct ctacaaatat aaagaggcgg cgtctttgcg tgagacgttg tgtaatggta 152100 tagactcaca taatatgcgt gatcgccaac aacgctggat gccatcgcat tatgctcctc 152160 tcactcctat gcctcaacga tacagcaaac atcttgcccc caagggaact cctgttgttg 152220 tacatttacc ggatgttatg gaaccctggc tggaaattaa agattatggg gttggtcttc 152280 cattagaaat gatcatcggc gagcctatta cagcgcgtga agatgaagtg ctggttgaag 152340 gtaatatcgt cgtgaaggaa gacgaaatcc ctgatagcac tgctgttatt ggtacacctg 152400 gttattataa tggggtactg gtattccgcg ctgaggatgg cgagatcatt cgtggtcctg 152460 gtttgtatac aacactcttc catagtacaa aagaggacga cgacgggcaa ataggggcgt 152520 ttgggctagg ttctaaatcc ccatttgcgg tatctgattc atttacagta gaaagtcgct 152580 atgaagggaa actgtatcgc ttcctgatgt atctgaatgc ggacagaatc ccaactgtag 152640 atctcattac caaggattta gatacccgtg atcctaaacc ggaagacact gatgagttca 152700 acggcctgac tgttaaagtt cctgtaaaga atcagcgttt taccgccttt gaacaagagt 152760 tggtccgttt gggtcgagtg atgcgacctt caatgcgacc gaaggttgaa aacgccagtt 152820 attctttccg ttggtctgac atcaacttcg aaaaccgtgt aggcaacacg tatattcagc 152880 cgaagtcaga ttccgacaac atccactatg ctgtcatggg cggggtttct tacccgatag 152940 atctcgacca attggactct gaaatatgca ccgtgctgga aaaattcccg agttcctata 153000 ccttcttcga acttggagaa ttgaatgttc ctccatcacg tgaagacttg tcatatgacg 153060 agttcacccg tgaaagcctg aaccgagtgt tcaaatatgt ggctgacaat attatgcagg 153120 cgaagatgta tgaacttcgc caggccgaat ctatgggtcc tcttatgctt tatatgaaga 153180 aggctcaatt gaccgatatg ttcggtagcg gtttccgtaa attagtggag cgagaatttc 153240 ctgcagataa ccgtttctac aaaggcacgt tccgttatat cggagcgccg gacgtcgtgc 153300 gcgattactc tttggatgca cctttccggt ctattggtag tccttacgaa attgaagtac 153360 acgacaacgg tgtagtacac gacagcattt atgtgaactc tgtcggaaat tggttgaaat 153420 ctaaatcaaa aattgctgtt attattgata actcgaatcg tgctcgaaac ctgaagatac 153480 aaacagcacg caataacttc aatgtcgtta tcgtcgtcaa accgaatgaa aattatttca 153540 gtaatcggaa tcagctggcg gcacataaag aatcatttac caaccatgag gaattgaagt 153600 cttattttga atcatggatc ggtgtacaag aaacaacgcc ggactacctg gtctttgccg 153660 ataaactgat cgaggtcttt ggcgatttat tcaatccgga tgaagtctat ttcatgcatg 153720 aaatggaata tgttcgcccg accgttgaaa aagatcctgg gatgtttagt ttccattaca 153780 attcatttaa cttcgaccgc gtttatgaat tagatggaaa aaccgtttca gatattattg 153840 attcgggcaa aaagatcgta tatatcgaag tatctggccg agaaggtatc cataaaattc 153900 atggtaatac cttacgacaa tccgcggctg gacatttgcg tgaagcgatg gaaagaacga 153960 agttcggcga gaatggaaac gaaaacctgt ttgatttgct gggagcacat ccaacaatcg 154020 ttcttgcgcg tcgtaaatct gttccgatga tgaagaaatt cccagaagta ttcatcccca 154080 ttgacgcagt gtttgatatg ttgcttgagc attataaaga tgaatttcag gcgcttgaat 154140 ctaagaaact cctgaaactt cgcaagggca taaacatcat gtctcatcgc attgattatg 154200 gtgccaagct gttgattgat tcccatggaa aagttacgga tggctatgcc catcatcaac 154260 acagggcaaa agcaatcatc agttatgcga aacaacaaat cactgaagaa gaatggaaga 154320 ttgttcgtat gctggccaaa cgaaatccgt ctggatcggg gtacggttat ttccgcaagg 154380 ctgttgagga attacattat catatagaaa tgcctttctc aactacgaga tttttccgcg 154440 cctgtaacca gttaactcaa gttgttgatt tattgaatga aaaattaact gctgaaggat 154500 ttgatgagat aaaggtcact agcactatat ctcaaaagca aaaggccaaa aaccgatacc 154560 gagttgaatg tcatcgtttg gtgaaattca tgatgtcaaa atatcagcct tcggcacaca 154620 acgcgattga agatgccact agatttgtga aggctatttc aaaacgtatt ctcggggcat 154680 aatagcccca ttaccccaca gtgagaacta caagatgaat gctatagaaa aacgtattct 154740 caagctgttg aatgagaaca gaagtcaaag ttcaatagcc agtgaattgg gcgtaccgcg 154800 ctcaatgata caacgcgtgt cggataaaga actgggagtg gatccagctt cgattaagtc 154860 tctgaccact gaacagattc aagaaataca aaccaagagc agcaaaggtg aaagcaattc 154920 ttctctggca tcagtttatg gcgtcagtgc caaaacaatt gcccgcgccc tgatggttcg 154980 tatcatcaaa gaatctaata acgtggtcgt gatttcgcca attaaagaat tgactgaaga 155040 agggaaaatc cccgacacct atgaagttct ggaaggttcg gtgtctgtcg attctgaagg 155100 cgaagaatgg tatgttggcc gtttcctgga aaaccaaaca gtgtttatct gtatgcgtta 155160 cgatagctct gctgctattc aggccaaact tttcagaagc gaagaactga aaccgttaga 155220 aactcggtca agccgcttca atgaagaaaa catttctccg ttggccgaat tggcgacagc 155280 actggttgat ggcgttacca aagtcaatga cggcgtggta atcagtgtac aacatgacgg 155340 cgaaacatac ccgatgcgcg gttcccttga tgcccgtcgg cgtgtgggat actttgacgc 155400 aattctgggg cgtacacttc gactggcgtt gtcgtctgtt gttttctcgg ttaagacaac 155460 ggctgttgag gaagagtctg gcgacaaaca aactcaaaac tcatttaaag aaaaagatct 155520 gtcagtgttc ttgaatgagc accagatcat gattttaccg gaaagcatcg ttatcgttat 155580 ggatggcaaa ccggaaacga taaccacaag ccatcaggcg tatgatcgta ttgttgaagc 155640 gattaaaaat cgtgacgtca aaacagcgta cactctgatg aaaccgcgtg aagccatcag 155700 caaattcact acaggcatgg ttgatttatc tgacaaccgt gtgcgctggg gtggctatga 155760 catcacggga acttccgtcg ccaaacgcgt tttggcactg gcattaaaag gcgattatcc 155820 gt; ggttcagtcc ggtcgaatct atgaattcat ggcatattcg gatatcgaaa ttcatgaaga 155940 cggtgatatc atcctgtata aatccgttcg cggtaactac atggacaagc gcacaggaaa 156000 agttagtaat gctcctggca ccattgttcg aatggctcgc tcatttgtga acgataacaa 156060 caaagatctg tgctcttacg gtcttcacgt ttgttctctg gcttatctga aacaatgttt 156120 tggtagcctg ggacaacgcg ttgtccgttg caaactgaac ccgaaagata tcgtgtctat 156180 cactgatgat tatggctcca gtaaaatccg ctgctgtgaa tatctggtat tagacgatta 156240 caccacggaa tacaaccgcc aacataaatc cattgatgtt gaaggtctat acaagtaagt 156300 gtaaatggat ataaaaggga ggcttcggcc tccttttctt tgaggtgaat atggaaacta 156360 gagatgttta cttcgtgtat gaacaacaag catttggttc attacgccgg aaaacaaaat 156420 tccttgttga ttcattccaa tttgatggag aactcaagga atactcgttc aggaattttc 156480 ctccgagaga agtcataggc gaccagttcg tgaaattatt ttgtcgttgt ggcggctgtg 156540 actttaacga cgacggatat tccatgcatg tttattgctg caatt 156585

Claims (11)

살모넬라균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어지고, 수탁번호 KFCC11690P인, 박테리오파지 SP1.
Bacteriophage SP1, consisting of the nucleotide sequence shown in SEQ ID NO: 1 and having the accession number KFCC11690P, which has a killing activity specific to Salmonella.
삭제delete 제1항에 있어서, 상기 살모넬라균은 살모넬라 플로럼(Salmonella Pullorum), 살모넬라 엔테리티디스(Salmonella Enteritidis) 및 살모넬라 갈리나륨(Salmonella Gallinarum)으로 구성된 군으로부터 선택된 1종 이상인, 박테리오파지 SP1.
The bacteriophage SP1 according to claim 1, wherein the Salmonella is at least one selected from the group consisting of Salmonella Pullorum, Salmonella Enteritidis and Salmonella Gallinarum.
삭제delete 삭제delete 제1항의 박테리오파지 SP1을 포함하는, 항생용 조성물.
An antibiotic composition comprising the bacteriophage SP1 of claim 1.
제1항의 박테리오파지 SP1을 포함하는, 사료 첨가용 조성물.
A composition for feed addition comprising the bacteriophage SP1 of claim 1.
제7항의 사료 첨가용 조성물을 포함하는, 사료.
A feed comprising the feed additive composition of claim 7.
제1항의 박테리오파지 SP1을 포함하는, 소독제.
A disinfectant comprising bacteriophage SP1 of claim 1.
제1항의 박테리오파지 SP1을 포함하는, 세척제.
A cleansing agent comprising the bacteriophage SP1 of claim 1.
제1항의 박테리오파지 SP1을 인간을 제외한 개체에 투여하는 단계를 포함하는, 살모넬라균에 의한 감염성 질병의 예방 또는 치료 방법.A method for preventing or treating an infectious disease caused by Salmonella, comprising administering the bacteriophage SP1 of claim 1 to an individual other than a human.
KR1020160176983A 2016-12-22 2016-12-22 Novel Salmonella specific bacteriophage SP1 and antibacterial composition comprising the same KR101863593B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020160176983A KR101863593B1 (en) 2016-12-22 2016-12-22 Novel Salmonella specific bacteriophage SP1 and antibacterial composition comprising the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020160176983A KR101863593B1 (en) 2016-12-22 2016-12-22 Novel Salmonella specific bacteriophage SP1 and antibacterial composition comprising the same

Publications (1)

Publication Number Publication Date
KR101863593B1 true KR101863593B1 (en) 2018-06-01

Family

ID=62634890

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020160176983A KR101863593B1 (en) 2016-12-22 2016-12-22 Novel Salmonella specific bacteriophage SP1 and antibacterial composition comprising the same

Country Status (1)

Country Link
KR (1) KR101863593B1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113293143A (en) * 2021-06-30 2021-08-24 武汉格瑞农生物科技有限公司 Salmonella bacteriophage capable of reducing vertical transmission of salmonella pullorum and application thereof
CN115624111A (en) * 2022-10-27 2023-01-20 江门市旺海饲料实业有限公司 Feed for reducing morbidity mortality of chicks and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090030386A (en) * 2007-09-20 2009-03-25 주식회사 인트론바이오테크놀로지 Novel bacteriophage having killing activity specific to salmonella selected from infectious bacteriophages of salmonella gallinarum
KR20120070533A (en) * 2010-12-21 2012-06-29 씨제이제일제당 (주) Novel bacteriophage and antibacterial composition comprising the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090030386A (en) * 2007-09-20 2009-03-25 주식회사 인트론바이오테크놀로지 Novel bacteriophage having killing activity specific to salmonella selected from infectious bacteriophages of salmonella gallinarum
KR20120070533A (en) * 2010-12-21 2012-06-29 씨제이제일제당 (주) Novel bacteriophage and antibacterial composition comprising the same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Salmonella phage SFP10, complete genome, GenBank: HQ259103.1, 2011.12.27. *
Salmonella phage SFP10, complete genome, GenBank: HQ259103.1, 2011.12.27.*
Virology Journal. 2011, 8:498, pp. 1-14. *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113293143A (en) * 2021-06-30 2021-08-24 武汉格瑞农生物科技有限公司 Salmonella bacteriophage capable of reducing vertical transmission of salmonella pullorum and application thereof
CN113293143B (en) * 2021-06-30 2022-06-07 武汉格瑞农生物科技有限公司 Salmonella bacteriophage capable of reducing vertical transmission of salmonella pullorum and application thereof
CN115624111A (en) * 2022-10-27 2023-01-20 江门市旺海饲料实业有限公司 Feed for reducing morbidity mortality of chicks and preparation method thereof

Similar Documents

Publication Publication Date Title
CN107257853B (en) Novel enterohemorrhagic escherichia coli bacteriophage Esc-CHP-1 and application thereof in inhibiting enterohemorrhagic escherichia coli proliferation
CN112831474B (en) Wide lysis spectrum salmonella bacteriophage RDP-NSA-19050 and application thereof
CN107109373B (en) Novel bacteriophage and composition comprising the same
KR102224897B1 (en) Novel Polypeptide and Antibiotics against Gram-Negative Bacteria Comprising the Polypeptide
KR101723827B1 (en) Novel Aeromonas salmonicida bacteriophage Aer-SAP-1 and its use for preventing proliferation of Aeromonas salmonicida
KR101993121B1 (en) Novel Clostridium perfringens specific bacteriophage CP3 and antibacterial composition comprising the same
CN112771156A (en) Escherichia coli phage ESC-COP-14 and application thereof in inhibiting proliferation of pathogenic escherichia coli
KR101993122B1 (en) Novel Klebsiella genus bacteria specific bacteriophage KP1 and antibacterial composition comprising the same
KR101863593B1 (en) Novel Salmonella specific bacteriophage SP1 and antibacterial composition comprising the same
KR102016922B1 (en) Novel pathogenic Escherichia coli specific bacteriophage EC10 and antibacterial composition comprising the same
KR102066920B1 (en) Novel Cronobacter sakazakii specific bacteriophage CS3 and antibacterial composition comprising the same
KR101859974B1 (en) Novel Aeromonas hydrophila bacteriophage Aer-HYP-2 and its use for preventing proliferation of Aeromonas hydrophila
KR101871342B1 (en) Novel Salmonella specific bacteriophage ST1 and antibacterial composition comprising the same
KR102237011B1 (en) Novel Salmonella-specific bacteriophage and antibacterial composition comprising the same
KR102016919B1 (en) Novel Salmonella specific bacteriophage SC1 and antibacterial composition comprising the same
KR102193495B1 (en) Novel Acinetobacter baumannii specific bacteriophage AB63 and antibacterial composition comprising the same
KR20190079031A (en) Novel Cronobacter sakazakii specific bacteriophage CS4 and antibacterial composition comprising the same
KR101842673B1 (en) Novel Salmonella specific bacteriophage SE1 and antibacterial composition comprising the same
KR102016921B1 (en) Novel Salmonella specific bacteriophage SE131 and antibacterial composition comprising the same
KR102016920B1 (en) Novel Clostridium perfringens specific bacteriophage CP5 and antibacterial composition comprising the same
KR102125235B1 (en) New Bacteriophage for Prevention and Treating the Chicken Escherichia coli and Antibacterial Compositions Containing the Same
KR102193473B1 (en) Novel Klebsiella genus bacteria specific bacteriophage KP12 and antibacterial composition comprising the same
KR102003759B1 (en) Novel Salmonella specific bacteriophage SH9 and antibacterial composition comprising the same
KR102203675B1 (en) Novel Yersinia specific bacteriophage YE12 and antibacterial composition comprising the same
KR101871347B1 (en) Novel pathogenic Escherichia coli specific bacteriophage EC121 and antibacterial composition comprising the same

Legal Events

Date Code Title Description
E701 Decision to grant or registration of patent right
GRNT Written decision to grant