CN113577043A - Preparation process of far infrared physiotherapy plaster - Google Patents
Preparation process of far infrared physiotherapy plaster Download PDFInfo
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- CN113577043A CN113577043A CN202110823667.1A CN202110823667A CN113577043A CN 113577043 A CN113577043 A CN 113577043A CN 202110823667 A CN202110823667 A CN 202110823667A CN 113577043 A CN113577043 A CN 113577043A
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- acrylate
- far infrared
- meth
- preparation process
- infrared physiotherapy
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- 238000000554 physical therapy Methods 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 239000011505 plaster Substances 0.000 title claims abstract description 18
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims abstract description 61
- 239000000463 material Substances 0.000 claims abstract description 25
- 239000000203 mixture Substances 0.000 claims abstract description 23
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims abstract description 22
- 239000000843 powder Substances 0.000 claims abstract description 20
- 239000002904 solvent Substances 0.000 claims abstract description 18
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims abstract description 16
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 claims abstract description 16
- 238000006116 polymerization reaction Methods 0.000 claims abstract description 16
- 230000005855 radiation Effects 0.000 claims abstract description 16
- 229920002554 vinyl polymer Polymers 0.000 claims abstract description 16
- 239000011248 coating agent Substances 0.000 claims abstract description 12
- 238000000576 coating method Methods 0.000 claims abstract description 12
- 229920000058 polyacrylate Polymers 0.000 claims abstract description 12
- 238000010438 heat treatment Methods 0.000 claims abstract description 11
- 239000000919 ceramic Substances 0.000 claims abstract description 10
- 238000005520 cutting process Methods 0.000 claims abstract description 10
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 10
- 239000000853 adhesive Substances 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims abstract description 8
- 238000005096 rolling process Methods 0.000 claims abstract description 6
- 238000001035 drying Methods 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 claims description 14
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 12
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 9
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- -1 hydroxypropyl Chemical group 0.000 claims description 9
- 239000004342 Benzoyl peroxide Substances 0.000 claims description 6
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 6
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 6
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 6
- 235000019400 benzoyl peroxide Nutrition 0.000 claims description 6
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims description 6
- SWXVUIWOUIDPGS-UHFFFAOYSA-N diacetone alcohol Chemical compound CC(=O)CC(C)(C)O SWXVUIWOUIDPGS-UHFFFAOYSA-N 0.000 claims description 6
- 238000010894 electron beam technology Methods 0.000 claims description 6
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 6
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 claims description 5
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 5
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims description 4
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
- 239000003999 initiator Substances 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 4
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- JOLQKTGDSGKSKJ-UHFFFAOYSA-N 1-ethoxypropan-2-ol Chemical compound CCOCC(C)O JOLQKTGDSGKSKJ-UHFFFAOYSA-N 0.000 claims description 3
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 claims description 3
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims description 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims description 3
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 3
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims description 3
- VNKYTQGIUYNRMY-UHFFFAOYSA-N methoxypropane Chemical compound CCCOC VNKYTQGIUYNRMY-UHFFFAOYSA-N 0.000 claims description 3
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims description 3
- 239000000377 silicon dioxide Substances 0.000 claims description 3
- 235000012239 silicon dioxide Nutrition 0.000 claims description 3
- 239000004408 titanium dioxide Substances 0.000 claims description 3
- 239000011787 zinc oxide Substances 0.000 claims description 3
- 230000001070 adhesive effect Effects 0.000 abstract description 5
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 238000003786 synthesis reaction Methods 0.000 abstract description 2
- 208000002193 Pain Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000001678 irradiating effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000000379 polymerizing effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000013557 residual solvent Substances 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- 206010005963 Bone formation increased Diseases 0.000 description 1
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 1
- 206010050296 Intervertebral disc protrusion Diseases 0.000 description 1
- 206010050031 Muscle strain Diseases 0.000 description 1
- 206010034464 Periarthritis Diseases 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- 208000026137 Soft tissue injury Diseases 0.000 description 1
- 206010041591 Spinal osteoarthritis Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 description 1
- 208000036319 cervical spondylosis Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 208000005801 spondylosis Diseases 0.000 description 1
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Images
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0625—Warming the body, e.g. hyperthermia treatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2/00—Processes of polymerisation
- C08F2/46—Polymerisation initiated by wave energy or particle radiation
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/12—Esters of monohydric alcohols or phenols
- C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
- C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
- C08F220/1808—C8-(meth)acrylate, e.g. isooctyl (meth)acrylate or 2-ethylhexyl (meth)acrylate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/12—Esters of monohydric alcohols or phenols
- C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
- C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
- C08F220/1809—C9-(meth)acrylate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
- A61N2005/066—Radiation therapy using light characterised by the wavelength of light used infrared far infrared
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Radiology & Medical Imaging (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pathology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to the technical field of irradiation synthesis medical instrument physical therapy patch sheet materials, in particular to a preparation process of a far infrared physical therapy patch. The preparation process comprises the following steps: s1, preparation of an acrylate solution: mixing acrylate and a solvent to prepare an acrylate solution; s2, radiation polymerization: carrying out a ray-initiated polymerization process on the acrylate solution prepared by the step S1 to obtain polyacrylate pressure-sensitive adhesive; s3, mixing: dissolving and dispersing polyvinyl acetal (PVB) powder and far infrared ceramic powder into polyacrylate pressure-sensitive adhesive to form a mixture; s4, coating: rolling the mixture on non-woven fabric to form sheet material; s5, heating: drying the S4 coated sheet through a heating tunnel to remove the solvent; s6, cutting: and cutting the dried sheet material of S5 into self-adhesive far infrared physiotherapy plaster with fixed shape. The invention has the advantages that: the physical therapy patch has the adhesive property and does not depend on a back lining layer to help the adhesion.
Description
Technical Field
The invention relates to the technical field of irradiation synthesis medical instrument physical therapy patch sheet materials, in particular to a preparation process of a far infrared physical therapy patch.
Background
Cervical spondylosis, scapulohumeral periarthritis, lumbar disc herniation, lumbocrural pain, hyperosteogeny, arthritis, lumbar muscle strain, soft tissue injury, myofibrositis and the like are common chronic diseases in clinic, and the clinical manifestations are pain at the neck, shoulder, waist, leg, joints and other parts, and are accompanied with symptoms of swelling pain, numbness, movement difficulty, dizziness, tinnitus and the like, the symptoms are frequently generated in middle-aged and elderly people, and office computer operators who keep a posture for a long time, the disease course is long, the illness state is very easy to repeat, if the patient can not be treated in time, limb dysfunction can occur, and then the movement is limited, and the daily life of the patient is seriously affected.
Discomfort of disease people can adopt oral medication, but most of the medicines can generate certain side effects while generating curative effect; the traditional acupuncture therapy has better relieving and treating effects on common diseases, but the needle can be safely applied by professional personnel.
Therefore, the medical application with reasonable preparation process and far infrared function can be convenient for patients to simply solve the problem of treating chronic diseases.
Disclosure of Invention
The invention provides a preparation process of a far infrared physiotherapy plaster, and the prepared far infrared physiotherapy plaster sheet has the characteristic of self adhesion, does not need a back lining layer to have an adhesion function, and has the function of adhering skin in an adhesive way.
In order to achieve the purpose, the invention adopts the following technical scheme:
a preparation process of a far infrared physiotherapy plaster comprises the following steps:
s1, preparation of acrylate: preparing an acrylate solution, wherein the concentration of the solution is preferably 5-30%;
s2, radiation polymerization: carrying out a ray-initiated polymerization process on the acrylate solution prepared by the step S1 to obtain polyacrylate pressure-sensitive adhesive;
s3, mixing: dissolving and dispersing polyvinyl acetal (PVB) powder and far infrared ceramic powder into polyacrylate pressure-sensitive adhesive to form a mixture, wherein the mixture has viscous fluid with certain fluidity, and the viscous mixture is suitable for achieving the viscosity suitable for flowing and roll coating;
s4, coating: rolling the mixture on non-woven fabric to form sheet material;
s5, heating: drying the S4 coated sheet through a heating tunnel to remove the solvent;
s6, cutting: and cutting the dried sheet material of S5 into self-adhesive far infrared physiotherapy plaster with fixed shape.
Preferably, the solutes of the acrylate solution in S1 include: one or more of (meth) acrylic acid, methyl (meth) acrylate, ethyl (meth) acrylate, hydroxyethyl acrylate, n-butyl (meth) acrylate, hydroxypropyl (meth) acrylate, isooctyl (meth) acrylate, nonyl (meth) acrylate, decyl (meth) acrylate, neopentyl (meth) acrylate, hexyl (meth) acrylate, heptyl (meth) acrylate, and 2-ethylhexyl acrylate.
Preferably, the solvent of the acrylate solution in the process S1 includes one or more of methanol, ethanol, n-propanol, isopropanol, n-pentanol, benzyl alcohol, butanol, diacetone alcohol, propylene glycol ethyl ether/methyl ether/propyl ether, acetone, methyl ethyl ketone, cyclohexanone, dichloromethane, chloroform, methyl acetate, ethyl acetate, and butyl acetate.
Preferably, the radiation for the radiation-induced polymerization in the process S2 includes electron beam radiation and ultraviolet rays, and the radiation-induced polymerization in the process S2 needs to be used in combination with an initiator, and the initiator includes one or both of Azobisisobutyronitrile (AIBN) and Benzoyl Peroxide (BPO).
Preferably, in the process S3, the polyvinyl acetal (PVB) powder is a medium-low viscosity product, the 10% ethanol solution has a viscosity of less than 60mpa.s, and the far infrared ceramic powder is white powder with a fineness of more than 2000 meshes, contains zinc oxide, titanium dioxide, silicon dioxide and other components, can absorb external heat energy, and releases far infrared rays with a wavelength of 4-14 microns.
Preferably, in the process S5, the solvent content in the sheet to be removed by heating is 1.0% or less.
Preferably, the sheet material in the process S6 is cut into a shape according to the application requirements of the customer, and the sheet material is cut into a shape of a pasting type far infrared physiotherapy product.
The invention has the beneficial effects that: adopting electron beam or ultraviolet ray irradiation to initiate the process of polymerizing acrylate to synthesize polyacrylate pressure-sensitive adhesive, so as to provide bonding strength for the sheet physical therapy paste; polyvinyl acetal is dissolved into a solvent of the pressure-sensitive adhesive to form a viscose skeleton base material in a mixture, so that the adhesiveness of the physical therapy patch is improved; the mixture is roll-coated on the non-woven fabric in a coating mode to form a uniform sheet material, and the uniform sheet material is uniformly coated on the non-woven fabric, so that the medicine property is greatly improved; adopt the tunnel stoving mode to get rid of the solvent in the sheet, the effectual reduction is to the stimulation of skin, improves the comfortable impression of use of customer to the physiotherapy subsides.
Drawings
FIG. 1 is a schematic flow chart of a process for preparing a far infrared physiotherapy patch of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention.
Referring to fig. 1, the present embodiment is a process for preparing a far infrared physiotherapy patch, the process comprising the following steps:
s1, preparation of acrylate: preparing an acrylate solution, wherein the concentration of the solution is preferably 5-30%;
s2, radiation polymerization: carrying out a ray-initiated polymerization process on the acrylate solution prepared by the step S1 to obtain polyacrylate pressure-sensitive adhesive;
s3, mixing: dissolving and dispersing polyvinyl acetal (PVB) powder and far infrared ceramic powder into polyacrylate pressure-sensitive adhesive to form a mixture, wherein the mixture has viscous fluid with certain fluidity, and the viscous mixture is suitable for achieving the viscosity suitable for flowing and roll coating;
s4, coating: rolling the mixture on non-woven fabric to form sheet material;
s5, heating: drying the S4 coated sheet through a heating tunnel to remove the solvent;
s6, cutting: and cutting the dried sheet material of S5 into self-adhesive far infrared physiotherapy plaster with fixed shape.
Solutes of the acrylate solution described in S1 include: one or more of (meth) acrylic acid, methyl (meth) acrylate, ethyl (meth) acrylate, hydroxyethyl acrylate, n-butyl (meth) acrylate, hydroxypropyl (meth) acrylate, isooctyl (meth) acrylate, nonyl (meth) acrylate, decyl (meth) acrylate, neopentyl (meth) acrylate, hexyl (meth) acrylate, heptyl (meth) acrylate, 2-ethylhexyl acrylate, and the like.
The solvent of the acrylate solution in the process S1 includes one or more of methanol, ethanol, n-propanol, isopropanol, n-pentanol, benzyl alcohol, butanol, diacetone alcohol, propylene glycol ethyl ether/methyl ether/propyl ether, acetone, methyl ethyl ketone, cyclohexanone, dichloromethane, chloroform, methyl acetate, ethyl acetate, butyl acetate, and the like.
The radiation for the radiation-induced polymerization in the process S2 includes electron beam radiation, ultraviolet rays and the like, and the radiation-induced polymerization in the process S2 needs to be used in combination with an initiator including one or two of Azobisisobutyronitrile (AIBN), Benzoyl Peroxide (BPO) and the like.
In the process S3, the polyvinyl acetal (PVB) powder is a medium-low viscosity product, the viscosity of the 10% ethanol solution is less than 60mPa.s, and the far infrared ceramic powder is white powder which has the fineness of more than 2000 meshes, contains zinc oxide, titanium dioxide, silicon dioxide and other components, can absorb external heat energy and releases far infrared rays with the wavelength of 4-14 microns.
In the process S5, the solvent content in the sheet to be removed by heating is below 1.0%.
The sheet material in the process S6 is cut into a pasting type far infrared physiotherapy product with a certain shape according to the application requirements of customers.
Example 1
A far infrared physiotherapy plaster and a preparation process thereof comprise the following steps:
1) dissolving the following materials into 25% solution for later use;
| name of raw materials | Quantity (kilogram) |
| 2-ethylhexyl acrylate | 0.16 |
| Acrylic acid | 0.04 |
| Acrylic acid isooctyl ester | 0.1 |
| Acrylic acid ethyl ester | 0.12 |
| Acrylic acid n-butyl ester | 0.08 |
| Azobisisobutyronitrile | 0.0024 |
| Ethyl acetate | 1.5 |
| Total up to | 2.00 |
2) Irradiating the solution obtained in the step 1) by electron beam rays 21kGy to initiate polymerization to obtain polyacrylate pressure-sensitive adhesive;
3) adding 7.5 kilograms of polyvinyl acetal with the viscosity of 30mPa.s into the pressure-sensitive adhesive solution obtained in the step 2), dissolving uniformly, adding 3 kilograms of ceramic powder into the pressure-sensitive adhesive solution, and mixing uniformly to obtain a mixture;
4) rolling the mixture obtained in the step 3) on a non-woven fabric on a coating machine in a roll mode to form a sheet;
5) passing the sheet in the step 4) through a hot air tunnel with the temperature of 90-150 ℃ and the length of 8 meters to remove residual solvent in the mixture;
6) cutting the sheet material which is dried to remove the solvent and obtained in the step 5) into the far infrared physical therapy paste with a fixed shape by a cutter.
Example 2
A far infrared physiotherapy plaster and a preparation process thereof comprise the following steps:
1) dissolving the following materials into 21% solution for later use;
2) irradiating the solution obtained in the step 1) by ultraviolet rays to initiate polymerization to obtain polyacrylate pressure-sensitive adhesive;
3) adding 9 kg of polyvinyl acetal with the viscosity of 30mPa.s into the pressure-sensitive adhesive solution obtained in the step 2), dissolving uniformly, adding 4 kg of ceramic powder into the pressure-sensitive adhesive solution, and mixing uniformly to obtain a mixture;
4) rolling the mixture obtained in the step 3) on a non-woven fabric on a coating machine in a roll mode to form a sheet;
5) passing the sheet in the step 4) through a hot air tunnel with the temperature of 90-150 ℃ and the length of 8 meters to remove residual solvent in the mixture;
6) cutting the sheet material which is dried to remove the solvent and obtained in the step 5) into the far infrared physical therapy paste with a fixed shape by a cutter.
The invention has the beneficial effects that: adopting electron beam or ultraviolet ray irradiation to initiate the process of polymerizing acrylate to synthesize polyacrylate pressure-sensitive adhesive, thereby providing the performance of adhesive strength for the sheet physical therapy paste; one or more raw materials such as (methyl) acrylic acid, methyl (meth) acrylate, ethyl (meth) acrylate, hydroxyethyl acrylate, n-butyl (meth) acrylate, hydroxypropyl (meth) acrylate, isooctyl (meth) acrylate, nonyl (meth) acrylate, decyl (meth) acrylate, neopentyl (meth) acrylate, hexyl (meth) acrylate, heptyl (meth) acrylate, 2-ethylhexyl acrylate and the like are reasonably proportioned and polymerized into a glue solution, so that the balanced adhesive strength such as initial adhesion, permanent adhesion and the like of the pressure-sensitive adhesive is provided; mixing polyvinyl acetal with pressure-sensitive adhesive, and endowing the polyvinyl acetal with the performance of machine coating by using a solvent; the invention skillfully utilizes the characteristic that the solvent of the pressure-sensitive adhesive can also dissolve the polyvinyl acetal together, so that the polyvinyl acetal and the pressure-sensitive adhesive are well mixed; the polyvinyl acetal plays a role of bonding the adhesive skeleton base material of the ceramic powder, and the pressure-sensitive adhesive is distributed in the middle of the polyvinyl acetal base material to improve the adhesiveness of the physical therapy paste; the mixture is roll-coated on the non-woven fabric in a coating mode to form a uniform sheet material, and the uniform sheet material is uniformly coated on the non-woven fabric, so that the medicine property is greatly improved; the solvent in the sheet is removed by adopting a tunnel drying mode, so that the stimulation to the skin is effectively reduced, and the use feeling of a client to the physiotherapy patch is improved.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (7)
1. A preparation process of a far infrared physiotherapy plaster is characterized in that: the preparation process comprises the following steps:
s1, preparation of acrylate: preparing an acrylate solution, wherein the concentration of the solution is preferably 5-30%;
s2, radiation polymerization: carrying out a ray-initiated polymerization process on the acrylate solution prepared by the step S1 to obtain polyacrylate pressure-sensitive adhesive;
s3, mixing: dissolving and dispersing polyvinyl acetal (PVB) powder and far infrared ceramic powder into polyacrylate pressure-sensitive adhesive to form a mixture, wherein the mixture has viscous fluid with certain fluidity, and the viscous mixture is suitable for achieving the viscosity suitable for flowing and roll coating;
s4, coating: rolling the mixture on non-woven fabric to form sheet material;
s5, heating: drying the S4 coated sheet through a heating tunnel to remove the solvent;
s6, cutting: and cutting the dried sheet material of S5 into self-adhesive far infrared physiotherapy plaster with fixed shape.
2. The preparation process of the far infrared physiotherapy plaster according to claim 1, which is characterized in that:
solutes of the acrylate solution described in S1 include: one or more of (meth) acrylic acid, methyl (meth) acrylate, ethyl (meth) acrylate, hydroxyethyl acrylate, n-butyl (meth) acrylate, hydroxypropyl (meth) acrylate, isooctyl (meth) acrylate, nonyl (meth) acrylate, decyl (meth) acrylate, neopentyl (meth) acrylate, hexyl (meth) acrylate, heptyl (meth) acrylate, and 2-ethylhexyl acrylate.
3. The preparation process of the far infrared physiotherapy plaster according to claim 1, which is characterized in that: the solvent of the acrylate solution in the process S1 includes one or more of methanol, ethanol, n-propanol, isopropanol, n-pentanol, benzyl alcohol, butanol, diacetone alcohol, propylene glycol ethyl ether/methyl ether/propyl ether, acetone, methyl ethyl ketone, cyclohexanone, dichloromethane, chloroform, methyl acetate, ethyl acetate, and butyl acetate.
4. The preparation process of the far infrared physiotherapy plaster according to claim 1, which is characterized in that: the radiation for the radiation-induced polymerization in the process S2 includes electron beam radiation and ultraviolet rays, and the radiation-induced polymerization in the process S2 needs to be used in combination with an initiator including one or both of Azobisisobutyronitrile (AIBN) and Benzoyl Peroxide (BPO).
5. The preparation process of the far infrared physiotherapy plaster according to claim 1, which is characterized in that: in the process S3, the polyvinyl acetal (PVB) powder is a medium-low viscosity product, the viscosity of the 10% ethanol solution is less than 60mPa.s, and the far infrared ceramic powder is white powder which has the fineness of more than 2000 meshes, contains zinc oxide, titanium dioxide, silicon dioxide and other components, can absorb external heat energy and releases far infrared rays with the wavelength of 4-14 microns.
6. The preparation process of the far infrared physiotherapy plaster according to claim 1, which is characterized in that: in the process S5, the solvent content in the sheet to be removed by heating is below 1.0%.
7. The preparation process of the far infrared physiotherapy plaster according to claim 1, which is characterized in that: the sheet material in the process S6 is cut into a pasting type far infrared physiotherapy product with a certain shape according to the application requirements of customers.
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| CN202110823667.1A CN113577043A (en) | 2021-07-21 | 2021-07-21 | Preparation process of far infrared physiotherapy plaster |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114558098A (en) * | 2022-03-25 | 2022-05-31 | 湖南有美生物科技有限公司 | Preparation method and application of far infrared physiotherapy patch |
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| US4976706A (en) * | 1988-06-15 | 1990-12-11 | Tachibana Textile Fabrics, Co., Ltd. | Sheet material of germanium and ceramic for skin contact medical treatment |
| JPH0898897A (en) * | 1994-09-30 | 1996-04-16 | New Oji Paper Co Ltd | Far infrared radiation sheet |
| KR20010077445A (en) * | 2000-02-02 | 2001-08-20 | 김윤 | Diclofenac patch containing ceramic |
| JP2010083909A (en) * | 2008-09-29 | 2010-04-15 | Sekisui Chem Co Ltd | Resin composition |
| CN202724472U (en) * | 2012-06-21 | 2013-02-13 | 山东朱氏堂医疗器械有限公司 | Far-infrared physiotherapy plaster |
| CN109432167A (en) * | 2018-12-10 | 2019-03-08 | 浙江臻艾生物科技有限公司 | A kind of external application physical therapy plaster and preparation method thereof that can be recycled |
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2021
- 2021-07-21 CN CN202110823667.1A patent/CN113577043A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4976706A (en) * | 1988-06-15 | 1990-12-11 | Tachibana Textile Fabrics, Co., Ltd. | Sheet material of germanium and ceramic for skin contact medical treatment |
| JPH0898897A (en) * | 1994-09-30 | 1996-04-16 | New Oji Paper Co Ltd | Far infrared radiation sheet |
| KR20010077445A (en) * | 2000-02-02 | 2001-08-20 | 김윤 | Diclofenac patch containing ceramic |
| JP2010083909A (en) * | 2008-09-29 | 2010-04-15 | Sekisui Chem Co Ltd | Resin composition |
| CN202724472U (en) * | 2012-06-21 | 2013-02-13 | 山东朱氏堂医疗器械有限公司 | Far-infrared physiotherapy plaster |
| CN109432167A (en) * | 2018-12-10 | 2019-03-08 | 浙江臻艾生物科技有限公司 | A kind of external application physical therapy plaster and preparation method thereof that can be recycled |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114558098A (en) * | 2022-03-25 | 2022-05-31 | 湖南有美生物科技有限公司 | Preparation method and application of far infrared physiotherapy patch |
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