CN113545484A - 一种抗糖化美白的茶黄素组合物及其应用 - Google Patents
一种抗糖化美白的茶黄素组合物及其应用 Download PDFInfo
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- CN113545484A CN113545484A CN202110841330.3A CN202110841330A CN113545484A CN 113545484 A CN113545484 A CN 113545484A CN 202110841330 A CN202110841330 A CN 202110841330A CN 113545484 A CN113545484 A CN 113545484A
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- theaflavin
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- A23F3/00—Tea; Tea substitutes; Preparations thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A—HUMAN NECESSITIES
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Abstract
本发明涉及一种抗糖化美白的茶黄素组合物及其应用,按重量份计,包括以下组分:弹性蛋白5~10份,茶黄素5~10份,橄榄果粉5~10份,烟酸或烟酰胺0.1~0.2份,胶原三肽100~200份,维生素C 3~8份。本发明抗糖化美白的茶黄素组合物,各成分协同增强作用,将其添加至保健品中,无糖,易于被人体吸收,能够改善由糖化、氧化和黑色素所引起的皮肤泛黄、暗沉的色泽问题。
Description
技术领域
本发明属于保健食品技术领域,具体涉及一种抗糖化美白的茶黄素组合物及其应用。
背景技术
随着经济的发展和文明的进步,人们特别是女性更加关注肌肤肤色,追求肌肤白皙。一般的美白产品的关注点集中于黑色素的改善方面,从减少黑色素的生成及分布达到美白皮肤的效果。随后在一些科学研究中发现,皮肤的色泽暗沉除了黑色素的因素外,还因皮肤受活性氧自由基的作用或非酶糖基化作用而生成脂褐素及AGEs产物,随着年龄的增长,人体的新陈代谢放缓,AGEs在体内不断累积,导致真皮胶原蛋白发生交联,皮肤弹性下降,不仅会破坏肌肤中的胶原蛋白和弹性纤维,使肌肤失去弹性、出现皱纹,还会影响新陈代谢,使肌肤暗沉发黄、色斑生成、干燥粗糙等。
中国专利CN 201910064750.8公开了一种美白组合物、包含美白组合物的美白亮肤霜及其制备方法,其美白组合物由人参、桑白皮、当归、甘草、茶叶、黑灵芝、红景天、银杏叶八种中药材提取液配合传统美白剂烟酰胺和传明酸,具有协同美白和降低刺激性功效。但其美白组合物为针对单独黑色素的美白产品,美白效果有限,不能有效改善皮肤泛黄、暗沉的色泽问题。
发明内容
本发明的目的是提供一种抗糖化美白的茶黄素组合物,无糖,易于被人体吸收,能够改善由糖化、氧化和黑色素所引起的皮肤泛黄、暗沉的色泽问题。
本发明解决上述问题所采用的技术方案为:一种抗糖化美白的茶黄素组合物,按重量份计,包括以下组分:
弹性蛋白 5~10份
茶黄素 5~10份
橄榄果粉 5~10份
烟酸或烟酰胺 0.1~0.2份
胶原三肽 100~200份
维生素C 3~8份
本发明提供的各成分的功效如下:
弹性蛋白:弹性蛋白在肌肤中扮演橡皮筋的角色,让肌肤有伸展和褶合的能力,其功用就如床垫中的弹簧,负责维持与支撑肌肤的弹性。
茶黄素:不仅具有抗氧化作用,还能有效抑制酪氨酸酶活性来抑制黑色素的产生,其中,酪氨酸酶参与黑色素的形成,体内的酪氨酸在酪氨酸酶的作用下转化成多巴、多巴色素、多巴醌等,最终转化为色素颗粒,造成皮肤色素沉着。
橄榄果粉:具有抗氧化、推迟胶原流失、抑制黑色素、净白美肌的作用。
烟酸或烟酰胺:烟酸在体内可生成烟酰胺,烟酰胺能够作用在肌肤上,抑制已经产生的黑色素,并减少黑色素向表层细胞转移,以达到加快肌肤的代谢,还具有增强皮肤屏蔽功能。
胶原三肽:是一种含有甘氨酸、脯氨酸(或羟脯氨酸)外加一个其他氨基酸的三肽,无需分解,容易且能够被人体充分吸收,能够极有效的渗入角质层、真皮层和头发根部细胞内,具有保湿、滋养、亮肤、紧肤、防皱、修复的作用。
维生素C:具有抗氧化、抗衰老、光保护、均衡肤色、祛痘的作用,还减少糖化反应。
优选的,一种抗糖化美白的茶黄素组合物,按重量份计,包括以下组分:
弹性蛋白 6份
茶黄素 6份
橄榄果粉 5份
烟酸或烟酰胺 0.18份
胶原三肽 100份
维生素C 5份
优选的,所述胶原三肽为平均分子量为250~300Da的胶原三肽。
本发明的另一目的是提供一种抗糖化美白的茶黄素组合物的应用,用于制备保健品。
优选的,所述抗糖化美白的茶黄素组合物占保健品总重量的1%~10%。
优选的,所述保健品的剂型为颗粒、丸剂、片剂、粉剂、胶囊、茶包或饮品。其中,保健品作为饮品,其饮品中还包括甜味剂和酸味剂,所述甜味剂为赤藓糖醇和甜菊糖苷,所述酸味剂为柠檬酸和柠檬酸钠。
与现有技术相比,本发明的优点在于:
(1)本发明抗糖化美白的茶黄素组合物为无糖配方,进而降低糖摄入,降低体内糖含量,避免糖和蛋白质结合、氧化形成AGEs,即降低了糖化风险。
(2)本发明抗糖化美白的茶黄素组合物,各成分协同增强作用,其中橄榄果粉、维生素C与茶黄素相互协同,大大提高抗氧化作用,大大降低糖化反应。
(3)本发明抗糖化美白的茶黄素组合物中弹性蛋白与胶原三肽具有协同增效作用,明显改善肌肤,且易于被人体充分吸收。
(4)本发明抗糖化美白的茶黄素组合物,各成分协同增强作用,将其添加至保健品中,无糖,易于被人体吸收,能够改善由糖化、氧化和黑色素所引起的皮肤泛黄、暗沉的色泽问题。
具体实施方式
以下结合实施例对本发明作进一步详细描述。
实施例1
一种抗糖化美白的茶黄素组合物,按重量份计,包括以下组分:
弹性蛋白 6份
茶黄素 6份
橄榄果粉 5份
烟酰胺 0.18份
胶原三肽 100份
维生素C 5份
其中,胶原三肽的平均分子量为270Da。
实施例2
一种抗糖化美白的茶黄素组合物,按重量份计,包括以下组分:
弹性蛋白 8份
茶黄素 8份
橄榄果粉 5份
烟酰胺 0.1份
胶原三肽 100份
维生素C 3份
其中,胶原三肽的平均分子量为250Da。
实施例3
一种抗糖化美白的茶黄素组合物,按重量份计,包括以下组分:
弹性蛋白 5份
茶黄素 8份
橄榄果粉 7份
烟酰胺 0.2份
胶原三肽 150份
维生素C 6份
其中,胶原三肽的平均分子量为270Da。
对比例1-5:一种抗糖化美白的茶黄素组合物,与实施例1的不同之处在于,各组分及其相应的重量百分比如下表所示:
应用实施例:饮品的制备
将实施例1-3和对比例1-5的抗糖化美白的茶黄素组合物,按下表配方制成饮品。
测试方法:
(1)受试者持续饮用实验饮品五个月,每天饮用一次,每次饮用300mL,受试者按照实验的指示在连饮五月进行面部测试,每月一次。
(2)受访者人群数目:80名年龄在35-50岁的健康女性受试者。
皮肤弹性测试:
使用德国Courage+Khazaka公司(德国CK公司)的皮肤弹性测试仪Cutometer®dual MPA580,所使用的探头是Reviscometer RV600弹性纤维组织测试探头,在面部同一区域,测试在使用实验样品前以及第3个月和5个月时的参数,每次测试五次取平均值(R2、R5、R7值,测试过程中负压恒定为450mbar)。
参数说明:
皮肤弹性指数R2、R5、R7越接近1,皮肤的弹性越好。
R2=Ua/Uf;R5=Ur/Ue;R7=Ur/Uf。
Uf—皮肤最大拉伸量。
Ue—恒定负压加到皮肤上后,0.1秒钟时皮肤的拉伸量,定位弹性部分拉伸量。
Ur—取消负压后,皮肤就会迅速恢复原状态,同样分为弹性部分值Ur,即取消负压0.1秒后,皮肤的恢复值和粘弹性部分值,或称塑性部分值。
Ua—从取消负压到下一次连续测试皮肤表面再加负压时皮肤的恢复值。
皮肤亮度测试:
使用德国Courage+Khazaka公司(德国CK公司)的多探头皮肤测试仪MPA10,所使用的探头是Mexameter MX18黑色素和红色素探头与Glossymeter GL200皮肤光泽度测试探头,在面部指定区域,测试在使用实验样品前以及第3个月和5个月时的参数。
同时使用Corneometer CM825水分测试探头与Tewameter TM300水分流失探头TEWL,测试在使用实验样品前以及第3个月和5个月时皮肤含水量和水分流失率。
参数说明:
黑素指数(MI):数值越低,则皮肤黑色素含量越少。
皮肤光泽度:数值越高,则皮肤光泽度越好。
皮肤含水量:数值越高,则皮肤水分含量越高。
水分流失率:数值越高,则皮肤水分流失越多。
抗氧化性能测试:
通过测定实施例及对比例的具有抗糖化和抗氧化的组合物制成的饮品对DPPH自由基的清除能力来评价其抗氧化性能。
测试方法:
比色法测定清除DPPH·自由基的能力。取2mL饮品加入浓度为0.20mmol/LDPPH的无水乙醇溶液于比色皿中,混匀,于常温避光30min,在517nm波长处测吸光度值A1,2mLDPPH的无水乙醇溶液与2mL无水乙醇混合后在517nm波长处测吸光度值A0,以及2mL无水乙醇与2mL面贴膜精华液在517nm波长处测吸光度值A2。
根据以下公式计算样品对DPPH·自由基的清除率:
DPPH·清除率(%)=[1-(A1-A2)/A0]×100%
食品安全性测试:
选取体重范围在17-23g的体征表现良好的雄性昆明小鼠、雌性昆明小鼠各40只,对80只小鼠进行随机分成8组,分别给与80只小鼠实施例1-3、对比例1-5的抗糖化美白的茶黄素组合物制备的饮品,持续饮用实验饮品五周,每天饮用一次,每次10mL。
试验结果为:持续饮用饮品五周后,80只小鼠全部健康存活,其生长发育、进食及食物利用率、血液生化指标、主要脏器均没有发现不良反应。可见本实施方式制备得到的饮品,食用安全可靠,可长期服用。
除上述实施例外,本发明还包括有其他实施方式,凡采用等同变换或者等效替换方式形成的技术方案,均应落入本发明权利要求的保护范围之内。
Claims (6)
1.一种抗糖化美白的茶黄素组合物,其特征在于:按重量份计,包括以下组分:
弹性蛋白 5~10份
茶黄素 5~10份
橄榄果粉 5~10份
烟酸或烟酰胺 0.1~0.2份
胶原三肽 100~200份
维生素C 3~8份。
2.根据权利要求1所述的抗糖化美白的茶黄素组合物,其特征在于:按重量份计,包括以下组分:
弹性蛋白 6份
茶黄素 6份
橄榄果粉 5份
烟酸或烟酰胺 0.18份
胶原三肽 100份
维生素C 5份。
3.根据权利要求1所述的抗糖化美白的茶黄素组合物,其特征在于:所述胶原三肽为平均分子量为250~300Da的胶原三肽。
4.根据权利要求1~3任一所述的抗糖化美白的茶黄素组合物的应用,其特征在于:用于制备保健品。
5.根据权利要求4所述的抗糖化美白的茶黄素组合物的应用,其特征在于:所述抗糖化美白的茶黄素组合物占保健品总重量的1%~10%。
6.根据权利要求4所述的抗糖化美白的茶黄素组合物的应用,其特征在于:所述保健品的剂型为颗粒、丸剂、片剂、粉剂、胶囊、茶包或饮品。
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114947141A (zh) * | 2022-05-16 | 2022-08-30 | 上海曙雅生物科技有限公司 | 一种具有皮肤美容功效的组合物及其用途 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102131492A (zh) * | 2008-08-27 | 2011-07-20 | 株式会社太平洋 | 含胶原肽的皮肤美容用组合物 |
CN102860925A (zh) * | 2012-08-30 | 2013-01-09 | 扬州泊瑞生物农业科技开发有限公司 | 茶黄素在制备酪氨酸酶抑制剂中的应用 |
CN109044892A (zh) * | 2018-11-01 | 2018-12-21 | 自贡莱德曼科技有限公司 | 一种治疗痘印的药用护肤精华液及其制备方法 |
CN109730232A (zh) * | 2019-03-19 | 2019-05-10 | 达威控股有限公司 | 一种美容养颜饮品及其制备方法 |
CN110478266A (zh) * | 2019-09-17 | 2019-11-22 | 广东丸美生物技术股份有限公司 | 富含胶原三肽的化妆品组合物、护肤化妆品及应用与制备方法 |
CN111067835A (zh) * | 2020-01-10 | 2020-04-28 | 西安润玉医疗科技有限公司 | 一种抗皮肤糖化反应的美白组合物及其制备方法 |
-
2021
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Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102131492A (zh) * | 2008-08-27 | 2011-07-20 | 株式会社太平洋 | 含胶原肽的皮肤美容用组合物 |
CN102860925A (zh) * | 2012-08-30 | 2013-01-09 | 扬州泊瑞生物农业科技开发有限公司 | 茶黄素在制备酪氨酸酶抑制剂中的应用 |
CN109044892A (zh) * | 2018-11-01 | 2018-12-21 | 自贡莱德曼科技有限公司 | 一种治疗痘印的药用护肤精华液及其制备方法 |
CN109730232A (zh) * | 2019-03-19 | 2019-05-10 | 达威控股有限公司 | 一种美容养颜饮品及其制备方法 |
CN110478266A (zh) * | 2019-09-17 | 2019-11-22 | 广东丸美生物技术股份有限公司 | 富含胶原三肽的化妆品组合物、护肤化妆品及应用与制备方法 |
CN111067835A (zh) * | 2020-01-10 | 2020-04-28 | 西安润玉医疗科技有限公司 | 一种抗皮肤糖化反应的美白组合物及其制备方法 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114947141A (zh) * | 2022-05-16 | 2022-08-30 | 上海曙雅生物科技有限公司 | 一种具有皮肤美容功效的组合物及其用途 |
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