CN113543797A - 用于调节rna的系统和方法 - Google Patents

用于调节rna的系统和方法 Download PDF

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CN113543797A
CN113543797A CN202080018393.2A CN202080018393A CN113543797A CN 113543797 A CN113543797 A CN 113543797A CN 202080018393 A CN202080018393 A CN 202080018393A CN 113543797 A CN113543797 A CN 113543797A
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rna
domain
cirts
dimerization
conjugate
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布莱恩·C·迪金森
西蒙尼·劳赫
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University of Chicago
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University of Chicago
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CN202080018393.2A 2019-01-04 2020-01-03 用于调节rna的系统和方法 Pending CN113543797A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201962788571P 2019-01-04 2019-01-04
US62/788,571 2019-01-04
US201962831342P 2019-04-09 2019-04-09
US62/831,342 2019-04-09
US201962903080P 2019-09-20 2019-09-20
US62/903,080 2019-09-20
US201962929339P 2019-11-01 2019-11-01
US62/929,339 2019-11-01
PCT/US2020/012169 WO2020142676A1 (en) 2019-01-04 2020-01-03 Systems and methods for modulating rna

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CN113543797A true CN113543797A (zh) 2021-10-22

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US (1) US20220048962A1 (https=)
EP (1) EP3906042A4 (https=)
JP (2) JP2022516919A (https=)
KR (1) KR20210124238A (https=)
CN (1) CN113543797A (https=)
AU (2) AU2020204917A1 (https=)
BR (1) BR112021013173A2 (https=)
CA (1) CA3125299A1 (https=)
IL (1) IL284516A (https=)
MX (1) MX2021008153A (https=)
SG (1) SG11202107209WA (https=)
WO (1) WO2020142676A1 (https=)

Cited By (2)

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CN114085837A (zh) * 2021-11-19 2022-02-25 中山大学 一种敲除基因ythdf1的细胞系及其构建方法
CN114685685A (zh) * 2022-04-20 2022-07-01 上海科技大学 编辑rna的融合蛋白及其应用

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US20210095296A1 (en) * 2019-09-29 2021-04-01 Technion Research & Development Foundation Limited Synthetic non-coding rnas
EP4110918A4 (en) * 2020-02-28 2024-04-03 The University of Chicago METHODS AND COMPOSITIONS COMPRISING TRANS-ACTING TRANSLATION ACTIVATORS
CN113583136A (zh) * 2021-04-25 2021-11-02 南方科技大学 一种植物激素脱落酸荧光分子探针及其用途
WO2022251264A1 (en) * 2021-05-24 2022-12-01 Donald Danforth Plant Science Center Compositions for rna-protein tethering and methods of using
JP2023040984A (ja) * 2021-09-10 2023-03-23 国立大学法人信州大学 Ｒｎａの編集方法及びｒｎａを編集するためのキット
KR20240082405A (ko) * 2021-10-08 2024-06-10 펜슬 바이오사이언시스 리미티드 합성 게놈 편집 시스템
WO2023150131A1 (en) * 2022-02-01 2023-08-10 The Regents Of The University Of California Method of regulating alternative polyadenylation in rna
US20250154508A1 (en) * 2022-02-25 2025-05-15 The University Of Chicago Methods and compositions for activating translation
US20250283062A1 (en) * 2022-05-02 2025-09-11 The University Of Chicago Systems and methods for modulating rna
EP4689118A1 (en) * 2023-03-31 2026-02-11 Duke University Compositions for and methods of engineering the transcriptome
GB202401827D0 (en) * 2024-02-09 2024-03-27 Ucl Business Ltd Therapy for dravet syndrome
CN119899820B (zh) * 2025-01-23 2026-04-03 深圳开悦生命科技有限公司 Dhx8融合蛋白及其制备方法

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US20170073705A1 (en) * 2012-12-06 2017-03-16 Sigma-Aldrich Co. Llc Crispr-based genome modification and regulation
CN108559738A (zh) * 2018-02-12 2018-09-21 南昌大学 一种植物rna修饰和编辑的系统及方法
WO2018191388A1 (en) * 2017-04-12 2018-10-18 The Broad Institute, Inc. Novel type vi crispr orthologs and systems

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EP4286517A3 (en) * 2013-04-04 2024-03-13 President and Fellows of Harvard College Therapeutic uses of genome editing with crispr/cas systems
EP3341410B1 (en) * 2015-08-24 2021-06-02 Cellectis Chimeric antigen receptors with integrated controllable functions
US20200291369A1 (en) * 2016-03-11 2020-09-17 Erasmus University Medical Center Rotterdam Improved CRISPR-Cas9 Genome Editing Tool
CA3025523A1 (en) * 2016-05-27 2017-11-30 Aadigen, Llc Peptides and nanoparticles for intracellular delivery of genome-editing molecules
CN110612353A (zh) * 2017-03-03 2019-12-24 加利福尼亚大学董事会 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向

Patent Citations (3)

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US20170073705A1 (en) * 2012-12-06 2017-03-16 Sigma-Aldrich Co. Llc Crispr-based genome modification and regulation
WO2018191388A1 (en) * 2017-04-12 2018-10-18 The Broad Institute, Inc. Novel type vi crispr orthologs and systems
CN108559738A (zh) * 2018-02-12 2018-09-21 南昌大学 一种植物rna修饰和编辑的系统及方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114085837A (zh) * 2021-11-19 2022-02-25 中山大学 一种敲除基因ythdf1的细胞系及其构建方法
CN114085837B (zh) * 2021-11-19 2024-04-12 中山大学 一种敲除基因ythdf1的细胞系及其构建方法
CN114685685A (zh) * 2022-04-20 2022-07-01 上海科技大学 编辑rna的融合蛋白及其应用
CN114685685B (zh) * 2022-04-20 2023-11-07 上海科技大学 编辑rna的融合蛋白及其应用

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SG11202107209WA (en) 2021-07-29
JP2025084877A (ja) 2025-06-03
KR20210124238A (ko) 2021-10-14
WO2020142676A1 (en) 2020-07-09
JP2022516919A (ja) 2022-03-03
EP3906042A4 (en) 2023-03-15
EP3906042A1 (en) 2021-11-10
IL284516A (en) 2021-08-31
MX2021008153A (es) 2021-08-11
US20220048962A1 (en) 2022-02-17
AU2026200853A1 (en) 2026-04-02
BR112021013173A2 (pt) 2021-09-28
AU2020204917A1 (en) 2021-08-19
CA3125299A1 (en) 2020-07-09

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