CN113508109A - 取代的杂环酰胺类化合物，其制法与医药上的用途 - Google Patents

取代的杂环酰胺类化合物，其制法与医药上的用途 Download PDF

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CN113508109A
CN113508109A CN202080018174.4A CN202080018174A CN113508109A CN 113508109 A CN113508109 A CN 113508109A CN 202080018174 A CN202080018174 A CN 202080018174A CN 113508109 A CN113508109 A CN 113508109A
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substituted
unsubstituted
independently
hydrogen
halogen
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CN113508109B (zh
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周福生
徐晓明
张磊涛
刘柱博
胡刚
丁茜
谢付波
郑彪
吕强
兰炯
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Genfleet Therapeutics Shanghai Inc
Zhejiang Genfleet Therapeutics Co Ltd
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Genfleet Therapeutics Shanghai Inc
Zhejiang Genfleet Therapeutics Co Ltd
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Engineering & Computer Science (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
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Abstract

一种对RIPK1具有选择抑制作用的取代的杂环酰胺类化合物及其药学上可接受的盐、立体异构体、溶剂化合物或前药，包含该化合物的药物组合物，及其在制备治疗RIPK1相关疾病或病症药物中的应用。

Description

PCT国内申请，说明书已公开。

Claims (21)

  1. PCT国内申请，权利要求书已公开。
CN202080018174.4A 2019-03-22 2020-03-20 取代的杂环酰胺类化合物，其制法与医药上的用途 Active CN113508109B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910221799 2019-03-22
CN201910221799X 2019-03-22
PCT/CN2020/080306 WO2020192562A1 (zh) 2019-03-22 2020-03-20 取代的杂环酰胺类化合物，其制法与医药上的用途

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CN113508109A true CN113508109A (zh) 2021-10-15
CN113508109B CN113508109B (zh) 2023-02-10

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US (1) US20220177462A1 (zh)
EP (1) EP3943488A4 (zh)
JP (1) JP7323637B2 (zh)
KR (1) KR20210141665A (zh)
CN (1) CN113508109B (zh)
AU (1) AU2020246313B2 (zh)
CA (1) CA3131337C (zh)
WO (1) WO2020192562A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116234550A (zh) * 2020-09-23 2023-06-06 劲方医药科技(上海)有限公司 芳甲酰取代的三环化合物及其制法和用途

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3167847A1 (en) * 2020-02-13 2021-08-19 Fusheng ZHOU Dihydronaphthyridinone compound, and preparation method therefor and medical use thereof
AR123793A1 (es) 2020-10-19 2023-01-11 Bristol Myers Squibb Co Compuestos de triazolopiridinilo como inhibidores de quinasas
TWI824626B (zh) * 2021-08-02 2023-12-01 大陸商勁方醫藥科技(上海)有限公司 Ripk1抑制劑的晶型及其酸式鹽和其酸式鹽的晶型

Citations (6)

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WO2006038116A2 (en) * 2004-10-07 2006-04-13 Warner-Lambert Company Llc Triazolopyridine derivatives as antibacterial agents
WO2009017822A2 (en) * 2007-08-02 2009-02-05 Amgen Inc. Pi3 kinase modulators and methods of use
WO2010007100A1 (en) * 2008-07-15 2010-01-21 Cellzome Ltd 7-substituted amino triazoles as pi3k inhibitors
CN106715422A (zh) * 2014-07-28 2017-05-24 忠南大学校产学协力团 新型茚衍生物、其制备方法以及包含其作为活性成分的用于预防或治疗视网膜疾病的药物组合物
WO2018148626A1 (en) * 2017-02-13 2018-08-16 Bristol-Myers Squibb Company Aminotriazolopyridines as kinase inhibitors
CN109053630A (zh) * 2018-08-22 2018-12-21 中国人民解放军第二军医大学 一种苯并噻唑类衍生物及其用途

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WO2006038116A2 (en) * 2004-10-07 2006-04-13 Warner-Lambert Company Llc Triazolopyridine derivatives as antibacterial agents
WO2009017822A2 (en) * 2007-08-02 2009-02-05 Amgen Inc. Pi3 kinase modulators and methods of use
WO2010007100A1 (en) * 2008-07-15 2010-01-21 Cellzome Ltd 7-substituted amino triazoles as pi3k inhibitors
CN106715422A (zh) * 2014-07-28 2017-05-24 忠南大学校产学协力团 新型茚衍生物、其制备方法以及包含其作为活性成分的用于预防或治疗视网膜疾病的药物组合物
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CN109053630A (zh) * 2018-08-22 2018-12-21 中国人民解放军第二军医大学 一种苯并噻唑类衍生物及其用途

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116234550A (zh) * 2020-09-23 2023-06-06 劲方医药科技(上海)有限公司 芳甲酰取代的三环化合物及其制法和用途

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CA3131337C (en) 2023-10-17
CN113508109B (zh) 2023-02-10
EP3943488A1 (en) 2022-01-26
JP2022528251A (ja) 2022-06-09
WO2020192562A1 (zh) 2020-10-01
AU2020246313B2 (en) 2022-08-04
EP3943488A4 (en) 2022-09-07
AU2020246313A1 (en) 2021-10-21
US20220177462A1 (en) 2022-06-09
CA3131337A1 (en) 2020-10-01
KR20210141665A (ko) 2021-11-23
JP7323637B2 (ja) 2023-08-08

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