CN113491666A - Gel containing phenol and application thereof - Google Patents
Gel containing phenol and application thereof Download PDFInfo
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- CN113491666A CN113491666A CN202010227013.8A CN202010227013A CN113491666A CN 113491666 A CN113491666 A CN 113491666A CN 202010227013 A CN202010227013 A CN 202010227013A CN 113491666 A CN113491666 A CN 113491666A
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- phenol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Inorganic Chemistry (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a gel paste, a preparation method and application thereof, wherein the gel paste comprises
Phenol and
Description
Technical Field
The present invention relates to a phenol-containing gel paste. Belongs to the field of pharmaceutical preparation.
Background
The use of phenol for the treatment of viral diseases has been reported, for example, in the article entitled "New clinical application of liquefied phenol", published in Chinese Hospital pharmaceutical journal 2005, 25(5) 454-: heating solid phenol in water bath to obtain liquefied phenol, applying on skin filiform wart, molluscum contagiosum, bid, and repeating for 3d to obtain the final product: has obvious curative effect.
A2% phenol-glycerol ear drop prepared in hospitals is commonly used for treating otitis media and otitis externa.
The irritation of such high concentration phenol solutions or liquefied phenol to the skin mucosa has been a cause of hindering the widespread use of phenol therapy.
Chinese patent literature discloses that the inventors are: leyushuhua, application No.: 2011101366399, title of the invention: an acupoint injection is prepared by mixing phenol solution with saturated solution of phenol and normal saline at normal temperature at a ratio of 0.5-2: 100. Because the solubility of phenol in water is 6.7g at normal temperature, the concentration of phenol converted into the concentration of phenol acupoint injection is
The acupoint injection uses a trace amount of phenol, but the pain of injection, the fear of injection for partial people, the risk of injection and the requirements of technicians using phenol injection therapy prevent the popularization and the application of the phenol injection therapy.
Disclosure of Invention
The inventor is interested in researching the safety therapy of phenol for many years, and after years of practice and exploration, the inventor finds that the gel paste or the plaster containing trace phenol can be used for treating various viral diseases, and does not have any harm to human bodies and irritation to skin and mucous membranes.
Generally, the treatment of molluscum contagiosum with a reduced phenol concentration means that there is no effect, so that it is rarely thought to reduce phenol to one percent, one thousandth or even one ten thousandth. Lishenghua creatively reduces to seven sixteenths of a ten thousandth, but the pain of acupuncture point injection and the natural risk of the injection make many people unwilling to use. The inventor tries to prepare a gel ointment from a trace amount of phenol, and surprisingly succeeds in smearing and acupoint application with a trace amount of phenol gel.
The technical scheme of the invention is realized as follows: by using only
As active ingredients in parts by weightPhenol and
the gel paste or the plaster with the gel paste matrix in parts by weight can treat various viral diseases.
The gel paste is prepared from
Phenol as active component, water soluble polymer as matrix comprising tragacanth, gelatin, starch, cellulose derivative, carbopol, sodium alginate, carbomer, etc. and water, glycerin, propylene glycol, etc., humectant, antiseptic, disodium EDTA or sodium citrate as metal complexing agent, and pH regulator.
It is characterized by that firstly, the phenol is dissolved in partial water or glycerine, and the rest ingredients in the prescription are made into water-soluble gel matrix according to the matrix preparation method, then mixed with medicinal solution and added with water to a sufficient quantity.
It is characterized by that the described viral diseases include cold virus, herpes virus, molluscum contagiosum virus and new corona virus, etc. The application of the gel ointment comprises diseases caused by cold virus, herpes virus, molluscum contagiosum virus, new corona virus and the like.
The following experimental examples serve to further illustrate the invention.
The following test examples and examples further demonstrate, but are not limited to, the present invention:
experimental example 1
First, from 1 month in 2018 to 3 months in 2020. The clinic of Jiren Tang mountain, Lobei, of Tang mountain carries out clinical observation on 60 cases of infectious molluscum, herpes simplex of perioral genital and cold, and the age is 2-80 years old.
II, judging the curative effect:
1. the standard of cure is as follows: clinical symptoms disappear completely, and no recurrence occurs after half a year of observation;
2. the effective standard is as follows: the clinical symptoms are partially disappeared or alleviated, and relapse occurs within half a year;
3. invalidation criteria: no change in clinical symptoms.
Thirdly, obtaining a result: 50 cases are cured, and the cure rate is 83.3 percent; 8 effective cases, the effective rate is 13.3%; ineffective 2 cases, ineffective 3.3%. The total effective rate is 96.6%.
Typical cases
Case one:
in the case of a certain Yue, male, 8 years old, molluscum contagiosum spreads over the front and back of the chest, and is applied with phenol gel paste in batches, and the wart completely disappears in the next or third day after each application without any discomfort.
Case two:
wangzhi, female, 14 years old. The infant patient is in clinic to see a doctor because of fever, cold and nasal discharge. Daub in Dazhui cave with phenol gel cream to apply ointment or plaster fixedly with blank, obviously alleviate the second day, apply ointment or plaster clean up yesterday's gel, daub Dazhui cave again, apply ointment or plaster fixedly with blank, the third day health resumes normally.
Case three:
guo in certain age, male, 50 years old, cold, floating pulse, headache, applying phenol gel paste on Dazhui acupoint, fixing with blank plaster, and completely recovering to normal the next day.
Case four:
when a certain ginger is used for women, the ginger is 45 years old, the herpes labialis is itchy and painful, the phenol gel ointment is smeared on the surface of the herpes, and the herpes is cured after 2 days, wherein the phenol gel ointment is used for two to three times a day.
The samples prepared according to examples 1 to 3 below can achieve the effects of experimental example 1.
Example 1
Phenol 1 g
Glycerol 19 g
Carbomer 10 g
20% sodium hydroxide solution (3.5 g sodium hydroxide in 14 ml purified water) 17.5 g
Xylitol 80 g
882.5 ml of pure water
(1) Weighing 10 g of carbomer, adding into 500 ml of purified water, and swelling overnight;
(2) adding 17.5 g of 20% sodium hydroxide solution into the acidic carbomer solution aqueous solution obtained in the step (1), and neutralizing until the pH value is close to neutral;
(3) weighing 1 g of phenol into 19 g of glycerol, and shaking to dissolve;
(4) adding the phenol-glycerol solution obtained in the step (3) into the step (2), and shaking to dissolve uniformly;
(5) adding 80 g of xylitol into the mixture obtained in the step (4), and shaking to dissolve the xylitol uniformly;
(6) adding the rest of water into the mixture obtained in the step (5), and shaking to dissolve the mixture uniformly for later use.
Example 2:
phenol 2 g
Glycerol (18 g)
Sodium carboxymethylcellulose 10 g
Adding purified water to 1000 ml
(1) Wetting sodium carboxymethylcellulose with appropriate amount of ethanol, stirring to obtain paste, adding about 800% purified water, heating to dissolve, and cooling to room temperature;
(2) weighing 2 g of phenol into 18 g of glycerol, and shaking to dissolve; (ii) a
(3) Adding the phenol-glycerol solution obtained in the step (2) into the step (1), and shaking to dissolve uniformly;
(4) adding the rest of water into the mixture obtained in the step (5), and shaking to dissolve the mixture uniformly for later use.
Example 3:
phenol 1.5 g
Glycerol 18.5 g
Polyvinyl alcohol 12420 g
Polyethylene glycol 40050 g
Adding purified water to 1000 ml
(1) Adding purified water of about 800 parts into polyvinyl alcohol 124 and polyethylene glycol 400, heating to dissolve, and cooling to normal temperature;
(2) weighing 1.5 g of phenol into 18.5 g of glycerol, and shaking to dissolve; (ii) a
(3) Adding the phenol-glycerol solution obtained in the step (2) into the step (1), and shaking to dissolve uniformly;
(4) adding the rest of water into the mixture obtained in the step (5), and shaking to dissolve the mixture uniformly for later use.
While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims; meanwhile, any equivalent changes, modifications and variations of the above embodiments according to the essential technology of the present invention are within the scope of the technical solution of the present invention.
Claims (7)
1. A gel paste for treating viral diseases is composed of 1-1 wt% of phenol as an active ingredient and 99-9999 wt% of a gel paste matrix, wherein the gel paste matrix is composed of water-soluble polymers and other auxiliary materials.
2. The gel ointment of claim 1, wherein the gel ointment comprises 1 ‰ -1 wt% of phenol as active ingredient, the water-soluble polymer as matrix can be tragacanth, gelatin, starch, cellulose derivative, carbopol, sodium alginate, carbomer, etc., water, glycerol or propylene glycol, etc., humectant and antiseptic can also be added, metal complexing agent disodium EDTA or sodium citrate can also be added, and acid-base regulator can also be added.
3. A gel ointment for treating viral diseases according to any one of claims 1 to 2, characterized in that said viral diseases include cold virus, herpes virus, molluscum contagiosum virus, new corona virus, etc.
4. The process for preparing a gel ointment for treating viral diseases according to any one of claims 1 to 2, wherein phenol is dissolved in part of water or glycerin, the remaining ingredients in the formulation are prepared into a water-soluble gel base according to a base formulation method, and the water is added to a sufficient amount after mixing with the drug solution.
5. A specific formulation and preparation method of the gel ointment for treating viral diseases according to any one of claims 1-2:
phenol 1 g
Glycerol 19 g
Carbomer 10 g
20% sodium hydroxide solution (3.5 g sodium hydroxide in 14 ml purified water) 17.5 g
Xylitol 80 g
882.5 ml of pure water
(1) Weighing 10 g of carbomer, adding into 500 ml of purified water, and swelling overnight;
(2) adding 17.5 g of 20% sodium hydroxide solution into the acidic carbomer swelling aqueous solution obtained in the step (1), and neutralizing until the solution is nearly neutral;
(3) weighing 1 g of phenol into 19 g of glycerol, and shaking to dissolve;
(4) adding the phenol-glycerol solution obtained in the step (3) into the step (2), and shaking to dissolve uniformly;
(5) adding 80 g of xylitol into the mixture obtained in the step (4), and shaking to dissolve the xylitol uniformly;
(6) adding the rest of water into the mixture obtained in the step (5), and shaking to dissolve the mixture uniformly for later use.
6. Use of a gel paste as claimed in any one of claims 1 to 2 or a gel paste prepared by a method of preparing a gel paste as claimed in any one of claims 3 to 5 in the preparation of an antiviral medicament.
7. The use according to claim 6, comprising the use in the manufacture of a medicament for the treatment of cold viruses, herpes viruses, molluscum contagiosum viruses, neocoronavirus and the like.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010227013.8A CN113491666A (en) | 2020-03-22 | 2020-03-22 | Gel containing phenol and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010227013.8A CN113491666A (en) | 2020-03-22 | 2020-03-22 | Gel containing phenol and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113491666A true CN113491666A (en) | 2021-10-12 |
Family
ID=77993085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010227013.8A Pending CN113491666A (en) | 2020-03-22 | 2020-03-22 | Gel containing phenol and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113491666A (en) |
-
2020
- 2020-03-22 CN CN202010227013.8A patent/CN113491666A/en active Pending
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| Date | Code | Title | Description |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20211012 |
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| WD01 | Invention patent application deemed withdrawn after publication |