CA1221640A - Pharmaceutical compositions for treating viral infections - Google Patents

Pharmaceutical compositions for treating viral infections

Info

Publication number
CA1221640A
CA1221640A CA000449020A CA449020A CA1221640A CA 1221640 A CA1221640 A CA 1221640A CA 000449020 A CA000449020 A CA 000449020A CA 449020 A CA449020 A CA 449020A CA 1221640 A CA1221640 A CA 1221640A
Authority
CA
Canada
Prior art keywords
weight
parts
composition
formulation
glycerine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000449020A
Other languages
French (fr)
Inventor
Nicola Pamukoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA000449020A priority Critical patent/CA1221640A/en
Application granted granted Critical
Publication of CA1221640A publication Critical patent/CA1221640A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/14Alkali metal chlorides; Alkaline earth metal chlorides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A B S T R A C T

Herpes virus infections and common cold viral infections in mammals are treated by application to the site of infection, of a formulation comprising glycerine, ethyl alcohol and an alkali metal halide.

Description

The present invention provides a novel pharmaceutical composition for use in treating viral infections in mammals, of the herpes viral family or common cold virus, by topical application to the external site of the infection. The composition comprises simple, economical ingredients in specified proportions, is safe and easy to prepare and apply, by the patient, and provides rapid alleviation of symptoms and sufferings of such virus infections.
Thus according to one aspect of the present invention, there is provided a pharmaceutical composition for use in topical application to alleviate virus infections of the herpes family of viruses and common cold virus, which comprises from about 2.5 to 5.0 parts by weight of glycerine, from about 1 to about 10 parts by weight of ethyl alcohol, and from 0 to about l part by weight of a physiologically acceptable alkali metal halide salt.
Preferably, such formulations are provided in a pharmaceutically acceptable carrier base. In a preferred embodiment of the invention, a liquid formulation is used, in which the above ingredients are dissolved in water, a suitable amount of water for use with the above formulation being from about 80 to about 120 parts by weight. The ingredients dissolve readily in water in the required amounts. It is, however, preferable that the solution o the pharmaceutical composition as above be relatively freshly made up, e.g. within about four weeks of use, since glycerine when used in amounts towards the upper limit of the specified range tends to come out of solution
- 2 - ~

1 A~ ~1~ '.~ O

after a period of time, unless the solution is kept ~n a cold environment.
The above formulation may also be prepared as a cream, using a standard cream base as carrier, including physiologically acceptable waxes, gums, emollients and the like, as is well-known in the art. A suitable relative amount of carrier to form a cream with the formulation of the invention is in the range 80-120 parts by weight.
The formulation according to the present invention may of course include other physiologically acceptable, inert ingredients in addition to those specified above, to improve the esthetic qualities thereof. Thus, colorants, perfumes, etc., may be added, in amounts sufficient to impart esthetic quality improvements thereto, but not sufficient to interfere with the general effectiveness of the composition.
According to a further aspect of the present invention, there is provided a prccess for treating viral infections in mammals, which comprises the topical administration to the virally infected site of the mammal of an effective amount of a pharmaceutical composition comprising from about 2.5 to about 5 parts by weight of glycerine, from about 1 to about 10 parts by weight of ethyl alcohol, and from about 0 to about 1 part by weight of a physiologically acceptable alkali metal halide salt.
For treatment of cold virus infections with compositions according to the present invention, it is preferred to use a liquid, solution formulation, and to apply it as nasal drops, deposited into the nostril of the patient, and thence :`

.
' ' " : -. ~ ., 1~ ~ lti~

into the nasal and post-nasal passageways. Suitably, the sufferer applies about 1-2 cc of the liquid solution formulation e.g. from a dropper, directly into the nostrils, initially at intervals of about 1 hour, but gradually decreasing the frequency of application, e.g. to 2 hours or longer, as the symptoms of the cold virus infection start to recede. In practice it is found that the patient's discomfort resulting from the cold viral infection is effectively completely alleviated after about 48 hours of the above treatment with the formulation according to the present invention.
In treating the sore or blister manifesting a herpes viral infection, either liquid or cream formulations can be suitably used. The liquid formulation is suitably applied, at room temperature, by means of a swab or other suitable applicator, to the location of the infection. Such application to the location is repeated at intervals of about 1 hour, until the patient experiences an alleviation of the pain and can observe a reduction in the size and swelling of the sore, whereupon the frequency of dosage can be reduced, e.g. to intervals of about 2 hours. Quicker and more effective treatment is obtained, of course, if applications start during the early visible manifestations of the infection. If application of the formulations according to the invention commences before the sores or blisters burst, a noticeable decrease in the swelling and a substantial relief of the discomfort is obtained after about 24 hours, whereupon the frequency of application can be reduced. After three days, with ' :
'''~~ ~, ' , ~'., ' ' ' , ~ ' :

very infrequent application during the third day, th~ visible and painful manifestations of the infection have normal~y disappeared.
If, however, treatment with the present composition does not commence until the viral infection has progressed to the stage where the sores or blisters have burst, treatment takes somewhat longer. Once again, it is suitable to apply the composition to the infected area at intervals of about 1 hour initially, whereupon the sores normally dry, crust and start to shrink 24 hours, and complete disappearance of the external manifestations is obtained in 3-4 days, normally.
The glycerine in the formulation is believed to perform the function of maintaining tissue flexibility, and increasing the permeability of the cell membrane (surface vulnerability) to allow ready entry thereto of the ethyl alcohol, active ingredient. The glycerine prevents irritation from the alcohol/salt mixture. Less than about 2.5 parts by weight is ineffective in this purpose, but the upper limit of glycerine in the composition is largely determined by the solution stability and solubility of the glycerine in the chosen medium, rather than by reasons of technical effect. Of course, glycerine should not be used in such large amounts, even in a cream formulation, that it effectively masks the effect of the composition as a whole.
Whilst it is not intended that the invention should be limited to any particular theory of operation, it is believed that the compositions of the invention have an effect on the -~ , ,: ' .

, interferon secreted by the applicable body cells. The composition, especially the ethanol, appear to stimulate appropriate interferon secretions from the virally infected cells, at least to assist in combatting the virus therein.
It is preferred to include an alkaline metal halide, preferably sodium chloride, in a liquid formulation according to the invention, so as to maintain proper saline compatibility with the body fluids. The preferred amount of sodium chloride is in accordance with standard medical practice in administration of saline solutions, to produce an isotonic solution, e.g. approximately 0.9% by weight of sodium chloride, in the total liquid solution. A preferred formulation according to the present invention comprises from O to 1 parts by weight of sodium chloride, from about 3 to about 5 parts by weight of glycerine, and from 3 to about 5 parts by weight of ethyl alcohol, along with approximately 90-100 parts by weight water, to make a homogeneous aqueous solution.
In making the aqueous solution formulation according to the present invention, no special temperatures or mixing equipment are necessary. Initially the salt and water are mixed together, then the alcohol is added, and finally the glycerine.
Standard mixing and agitation techniques can be employed, to obtain a homogeneous solution, storable for up to 4 weeks without apparent loss of efficiency.
The invention is further illustrated in the following specific, non-limiting examples.

`'-' ': ' .
, - -: - ~ ' -l~lt~O

An aqueous solution according to the invention was made up of the following ingredients:
0.9 parts by weight sodium chloride;
3 parts by weight glycerine;
4 parts by weight ethyl alcohol;
92.1 parts by weight water.

The ingredients were mixed in a standard mixing vessel, and a homogeneous solution prepared at room temperature by stirring agitation. The solution was then used to treat viral infections in humans, as described in the subsequent examples.

An adult male suffering from a common cold, manifested by constricted and inflamed nasal and sinus passages and other well known symptoms of a cold, administered to himself the composition as described in Example 1. Administration was performed topically, by filling a dropper with about 1 cc of formulation and depositing it into each nostril, and then working the composition into the nasal and post-nasal passages.
This treatment, administration of 1 cc to each nostril from a dropper, was repeated at approximately 1 hour intervals. After a few hours, the patient noticed a significant improvement in terms of the constriction of his nasal passages and other painful symptoms resulting from the cold, and thereby decreased the frequency of dosage to intervals of about 2 hours, further decreasing the frequency as the symptoms became alleviated.
After 48 hours the patient reported that all symptoms and manifestations of the cold had disappeared, and he felt and appeared completely cured.

An adult male human sufferer with herpes simplex type I
viral infection, manifesting itself in a lip sore, treated the sore with the composition described in ~xample 1. Treatment commenced at the first noticeable development of the lip sore, when inflammation and swelling first became apparent before bursting had occurred, by application of the composition from an absorbent swab, at intervals of 1 hour. The pain and swelling soon began to decrease, with the repeated hourly treatment. By the following day, there had been a noticeable decrease in this swelling and a considerable relief of discomfort, so that the frequency of application of the composition was reduced to intervals of two hours. The improvement continued and the frequency of application was decreased therewith, until, after 72 hours from the commencement of treatment, the sore resulting from the viral infection had totally visably disappeared and the patient reported no residual discomfort.

A child of approximately 6 years of age reported for treatment with extensive HSV I infections manifesting themselves in a plurality of sores and blisters in the mouth area, some of '~':" '' '',., ' ' - ~ ~ ` - ' : ' '., : ' - - ' --- . -.: -which had burst. The sores were treated topically with the liquid composition of Example 1, lnitially at intervals of 1 hour, and subsequently, as the sores began to dry and reduce in size, at intervals of two hours. The patient was reported to have made an excellent recovery, with all blisters and sores effectively disappeared, after about 4 days of this treatment.

An adult female patient suffered from HSV II infection, diagnosed as such by a gynecologist, and manifesting itself in a sore/blister in the vicinity of the patient's hip. This was reported to be a recurrence of a previous manifestation of HSV
II infection in its active state. The hip sore was treated with the formulation described in Example 1, by topical application from a soaked swab of the formulation, at hourly intervals, gradually decreasing the frequency of application as the condition of the sore improved. After three days of such treatment, the patient reported that the sore was completely cured.

.
.

Claims (3)

THE EMBODIMENTS OF THE INVENTION IN WHICH AN EXCLUSIVE PROPERTY
OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A pharmaceutical composition for topical application to virally infected sites of a mammal, said composition comprising:
from about 2.5 parts by weight to about 5.0 parts by weight of glycerine;
from about 1 to about 10 parts by weight of ethyl alcohol;
and from 0 to about 1 part by weight of a physiologically acceptable alkali metal halide salt.
2. The composition of claim 1 in the form of a topically applicable liquid solution, and additionally comprising from about 80 to about 100 parts by weight of water.
3. The composition of claim 1, wherein the alkali metal halide is sodium chloride, present in amounts of from about 0.8 to about 1 part by weight.
CA000449020A 1984-03-07 1984-03-07 Pharmaceutical compositions for treating viral infections Expired CA1221640A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000449020A CA1221640A (en) 1984-03-07 1984-03-07 Pharmaceutical compositions for treating viral infections

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA000449020A CA1221640A (en) 1984-03-07 1984-03-07 Pharmaceutical compositions for treating viral infections

Publications (1)

Publication Number Publication Date
CA1221640A true CA1221640A (en) 1987-05-12

Family

ID=4127353

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000449020A Expired CA1221640A (en) 1984-03-07 1984-03-07 Pharmaceutical compositions for treating viral infections

Country Status (1)

Country Link
CA (1) CA1221640A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002069887A3 (en) * 2001-02-28 2003-01-09 Thomas W Konowalchuk Virucidal compositions
US7045548B2 (en) 2001-02-28 2006-05-16 Life Force Technologies, Inc. Methods of inactivating viruses

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002069887A3 (en) * 2001-02-28 2003-01-09 Thomas W Konowalchuk Virucidal compositions
US7045548B2 (en) 2001-02-28 2006-05-16 Life Force Technologies, Inc. Methods of inactivating viruses
US7268163B2 (en) 2001-02-28 2007-09-11 Life Force Technologies, Inc. Method for treating an inflammation or lesion caused by a virus
US7399790B2 (en) * 2001-02-28 2008-07-15 Konowalchuk Thomas W Virucidal compositions
US7902258B2 (en) 2001-02-28 2011-03-08 Life Force Technologies, Llc Methods for preventing lesions caused by viruses of the Herpesviridae or Poxviridae family
US7981933B2 (en) 2001-02-28 2011-07-19 Life Force Technologies, Llc Method for treating an inflammation or lesion caused by a virus
US8853272B2 (en) 2001-02-28 2014-10-07 Topical Remedy, Llc Method for treating an inflammation or lesion caused by a virus
US8901172B2 (en) 2001-02-28 2014-12-02 Topical Rememdy, LLC Method for treating an inflammation or lesion caused by a virus
US9737498B2 (en) 2001-02-28 2017-08-22 Topical Remedy, Llc Method for treating an inflammation or lesion caused by a virus

Similar Documents

Publication Publication Date Title
CN108853312B (en) Polycinnamic alcohol external gel and preparation method thereof
US5801199A (en) Pharmaceutical composition for treating acute rhinitis
GB1577551A (en) Medication for topical application by ultrasound
EP0506658B1 (en) Compositions and method for treating painful, inflammatory or allergic disorders
WO1991004034A1 (en) Topical preparation for treatment of aphthous ulcers and other lesions
KR910005885B1 (en) Solution containing lysozyme hydrochloride and dipotassium gly cyrrhizinate
US5137718A (en) Infection fighting composition for topical application
JPH0216728B2 (en)
JP3543005B2 (en) Treatment of local infection
US4708873A (en) Method of chemically debriding uncerated necrotic tissue
CZ181193A3 (en) Pharmaceutical preparation in the form of a solution for local administration in eye, the use and preparation method thereof
CA1221640A (en) Pharmaceutical compositions for treating viral infections
US7790771B1 (en) Use of tosylchloramide(s) for treating disease of the skin, mucous membrane, organs and tissues
US5331012A (en) Topical pharmaceutical preparation for fever blisters and other viral infections and method of use
JP2010511723A (en) Topical pharmaceutical composition
JPH01230514A (en) Aerosol type patch external use
OLIVER-GONZÁLEZ et al. TREATMENT OF FILARIASIS BANCROFTI WITH HETRAZAN®: Follow-up Observations Fifteen Months After Treatment
KR20140041476A (en) The treatment of viral infections
RU2190388C1 (en) Preparation on base of tea tree oil (versions)
JPS5896012A (en) Method of accelerating absorptiok of vitamin e nicotinate in oral cavity
RU2426540C1 (en) Anti-inflammatory and anti-allergic medication and based on it pharmaceutical composition
RU2013087C1 (en) Salve for treatment of a patient with highmoritis, acute or atrophic rhinitis
JPS6277318A (en) Remedy for burn
EP0073758B1 (en) Treatment of inflammatory viral infections, acne, dermatitis and arthritis conditions
CN113491666A (en) Gel containing phenol and application thereof

Legal Events

Date Code Title Description
MKEX Expiry