RU2013087C1 - Salve for treatment of a patient with highmoritis, acute or atrophic rhinitis - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: salve composition contains the following ingredients, % by weight: clove oil 17-27; eucalyptus oil; peppermint oil 18-26 and propolis for the balance. EFFECT: high efficacy.

Description

 The invention relates to medicine, namely to agents for the treatment of acute and chronic rhinitis and sinusitis.

 Known treatment of vasomotor rhinitis, consisting in the fact that endosonally injected autoserum of the patient’s blood in microdoses. The disadvantage is that treatment is carried out only in stationary conditions.

 A number of drugs for the treatment of rhinitis are known, containing peppermint, lemon, eucalyptus oil and novocaine.

 It is known the treatment of purulent sinusitis with propolis.

 The disadvantage of these funds is the lack in the first case of biologically useful properties of propolis, in the second - the absence of oils that contribute to the extraction and intensification of the healing properties of propolis. In general, this reduces the therapeutic effect of the use of drugs.

 The aim of the invention is to increase the effectiveness of treatment and reduce the duration of treatment.

In the proposed cream, this is achieved by the fact that it additionally contains propolis and clove oil in the following ratio of ingredients, wt. %: Clove oil 27.. . 17 Eucalyptus oil 17.. . 27 Peppermint oil 26.. . 18 Propolis 30.. 38
Clove, eucalyptus and peppermint oils are used as a fat base in the cream formulation, while extracting propolis, they increase the biological activity of propolis and improve the absorption of the cream.

 Propolis, possessing antimicrobial, anti-inflammatory and local anesthetic properties, activates the activity of protective factors and increases the body's resistance. Essential oils, balms, and most importantly flavonoids and ferulic acid give the cream antiviral and antibacterial properties, act as a bactericidal, tonic and restorative epithelium in respiratory diseases, improves mucus secretion. Propolis diffuses well in the tissue, has an effect on depth, stimulates the regenerative process in the mucous membrane of the maxillary sinus, and this contributes to the final recovery.

 The presence of propolis below 30 wt. % does not provide the necessary therapeutic effect, and over 33 wt. % is impractical, because the degree of use of vitamins and trace elements found in propolis and extracted when extracted with oils is reduced.

 Galenic clove oil preparations have hypotensive and sedative properties, are devoid of irritating effects, and have low toxicity. They are used to eliminate crusts, reduce drying of the mucous membrane. Reducing clove oil below 17 wt. % reduces the penetration of the active principles of propolis, and an increase of over 27 wt. % creates an overwhelming effect, reduces the viscosity of the cream.

 To influence the inflammatory process, to reduce swelling of the mucous membrane, to facilitate the outflow of pathological separation from the paranasal sinuses and to improve their aeration, peppermint (26... 18 wt.%) And eucalyptus (17... 27 wt.%) Oils were introduced into the cream .

 Eucalyptus preparations have a bactericidal and bacteriostatic effect several times higher than the effect of penicillin. According to its disinfecting properties, the oil is three times higher than carbolic acid, but is less toxic.

 The decrease in the concentration of equal oil below 17 wt. % reduces antiseptic effects, and above 27 wt. % - causes a burning sensation of the mucous membrane of the airways during administration.

 Peppermint oil contains menthol, carotene, hesperidin, urosolic and oleic acids, and other terpenoids. It increases the local analgesic, antispasmodic and antiseptic properties of the cream, causes reflex expansion of the vessels of the heart, brain, lungs, which is important in the treatment of acute rhinitis in elderly patients, in which rhinitis exacerbation is associated with a change in temperature and atmospheric pressure, which causes an increase in blood pressure of the patient .

 Introduction to the cream of peppermint oil less than 18 wt. % is not enough for the necessary therapeutic effect, and an overdose of over 26 wt. % is associated with the development of a number of negative side effects of local and general resorption nature.

 The technology for preparing the cream consists of the following operations.

 PRI me R 1. In a melting enameled reactor with a steam jacket and a stirrer load 27 wt. % clove oil, 17 wt. % eucalyptus and 26 wt. % mint, then load 30 wt. % propolis, crushed to particles 5.. . 10 mm. The reactor is sealed.

The temperature is increased to 60.. . 30 ^about C and maintained until complete dissolution of propolis in oils with constant stirring for 20.. . 30 minutes.

 Then the cream in the hot state is filtered under vacuum through a 0.1 filter. . . 0.15 mm and after control is packaged.

PRI me R 2. In a melting enamel reactor with a steam jacket and a stirrer load 22 wt. % clove oil, 22 wt. % eucalyptus and 22 wt. % mint, then load 34 wt. % propolis, crushed to particles 5.. . 10 mm. The reactor is sealed. The temperature is increased to 60.. . 80 ^about C and maintained until complete dissolution of propolis in oils with constant stirring for 20.. . 30 minutes.

 Then, when hot, the cream is filtered and packaged after control.

PRI me R 3. In a melting enamel reactor with a steam jacket and a stirrer load 17 wt. % clove oil, 27 wt. % eucalyptus and 18 wt. % mint, then 38 wt. % propolis, crushed to particles 5.. . 10 mm. The reactor is sealed. The temperature is increased to 60.. . 80 ^about C and maintained until complete dissolution of propolis in oils with constant stirring for 20.. . 30 minutes.

 Then the cream is filtered while hot and packaged after control.

 Of the three examples cited, the second example most fully satisfies the purpose of the invention.

 The cream was clinically tested in the Dnipropetrovsk Research Institute of Gastroenterology in 12 patients. Recovery occurred in 9 patients, a temporary effect in 3 patients.

 In 9 cases, the cream is used for acute post-viral sinusitis and rhinitis. After a 4-day treatment, complete recovery came with the restoration of nasal breathing. In 3 cases, a temporary effect was obtained: in 1 patient, a 2-fold puncture of the maxillary cavity was required, then only the effect of applying the cream was obtained; 1 patient was diagnosed with a curvature of the nasal septum of the III degree, requiring surgical correction; 1 patient was diagnosed with seasonal allergic annual rhinitis and sinusitis. The treatment with plant hepatoprotectors cholesin and celandine was carried out according to the methodology of the institute, and then only after the use of Nazi cream the clinical effect was obtained. The treatment period is reduced by 4-5 times in comparison with the accepted treatment methods.

 PRI me R 4. Patient F., 18 years old, diagnosis: chronic cholecystopancreatitis. Concomitant disease: acute respiratory infection complicated by rhinitis and sinusitis. Applied cream "Nazi". In the evening at 18 o’clock the cream was introduced into the middle nasal passage. The cream was injected with the blunt end of a dental stick, at home a match with a cotton ball loaded on it. The amount of cream on both nasal passages is 1 g. Depth of administration is 2.5-3.5 cm. After administration of the cream, discomfort is noted: a slight burning sensation, nasal congestion, swelling of the mucous membrane. The duration of discomfort was 1.5-2 hours. Then the feeling of tension and pain in the nose disappeared, nasal breathing was restored, nasal discharge and lacrimation ceased. The cream is applied three days for 1 introduction, recovery.

 PRI me R 5. Patient M., 17 years. Diagnosis: chronic pancreatitis. Acute adenovirus infection. Acute sinusitis. Within 3 days, the introduction of Nazi cream. Temporarily for 1 week, nasal breathing was restored, the sensation of tension of pain in the affected sinus ceased, the sense of smell on the affected side was restored. An X-ray examination of the maxillary cavities was performed. Exudation was detected on the left. Twice a puncture of the sinuses with the removal of effusion. The use of the cream within 3 days after the puncture gave a full recovery.

 PRI me R 6. Patient A., 40 years. Diagnosis: chronic colitis, hepatitis. Concomitant disease: chronic allergic rhinitis and sinusitis. It is treated annually. Exacerbation occurs from June to September. Has been using a large number of medicines for 10 years. The effect is not noted; virtually no nasal breathing, a feeling of stuffiness in the nose and pain in the liver in the right hypochondrium. According to the methodology of the institute, hepatoprotectors choleazin and celandine were orally prescribed. In parallel, once a month for 4 days, the cream "Nazi". After 2.5 months of treatment, improvement. Observation 2 years. There is no aggravation.

 PRI me R 7. Patient S., 35 years. Diagnosis: chronic cholecystopancreatitis. Chronic sinusitis. More sinusitis for 15 years. Periodically, nasal discharge, nasal congestion, olfaction disorder, lacrimation. Once a month for 4 days applied cream "Nazi". Clinical signs of the disease disappeared. Conducted 3 courses of treatment for 4 days. Observation of 5 years. Remission. The main disease was successfully treated with plant extracts according to the methodology of the institute.

 Using the proposed tool shows good results.

Claims (1)

Cream for the treatment of sinusitis, acute and chronic rhinitis, containing peppermint and eucalyptus oil, characterized in that the cream additionally contains propolis and clove oil in the following ratio of components, wt. %:
Clove oil 17 - 27
Eucalyptus oil 17 - 27
Peppermint oil 18 - 26
Propolis Else