CN113474840B - 用于预测hla ii类特异性表位及表征cd4+ t细胞的方法和系统 - Google Patents

用于预测hla ii类特异性表位及表征cd4+ t细胞的方法和系统 Download PDF

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CN113474840B
CN113474840B CN201980092864.1A CN201980092864A CN113474840B CN 113474840 B CN113474840 B CN 113474840B CN 201980092864 A CN201980092864 A CN 201980092864A CN 113474840 B CN113474840 B CN 113474840B
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hla
peptide
drb1
presentation
cell
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CN113474840A (zh
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迈克尔·史蒂文·鲁尼
詹尼弗·格雷斯·阿贝林
杜米尼克·巴特尔梅
罗伯特·卡门
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Aetna Usa Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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CN201980092864.1A 2018-12-21 2019-12-20 用于预测hla ii类特异性表位及表征cd4+ t细胞的方法和系统 Active CN113474840B (zh)

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US201862783914P 2018-12-21 2018-12-21
US62/783,914 2018-12-21
US201962826827P 2019-03-29 2019-03-29
US62/826,827 2019-03-29
US201962855379P 2019-05-31 2019-05-31
US62/855,379 2019-05-31
US201962891101P 2019-08-23 2019-08-23
US62/891,101 2019-08-23
PCT/US2019/068084 WO2020132586A1 (en) 2018-12-21 2019-12-20 Method and systems for prediction of hla class ii-specific epitopes and characterization of cd4+ t cells

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CN (2) CN113474840B (https=)
AU (1) AU2019404547B2 (https=)
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