CN113466455B - Automatic processing device for virus screening in sputum collection - Google Patents
Automatic processing device for virus screening in sputum collection Download PDFInfo
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- CN113466455B CN113466455B CN202110890486.0A CN202110890486A CN113466455B CN 113466455 B CN113466455 B CN 113466455B CN 202110890486 A CN202110890486 A CN 202110890486A CN 113466455 B CN113466455 B CN 113466455B
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Abstract
The invention relates to an automatic processing device for screening viruses in sputum collection, wherein the device comprises: the detection chamber processing module is arranged right in front of the main view of the automatic processing device; the control module is arranged on the inner wall of the detection chamber processing module; the transmission module is arranged at the upper end part of the detection chamber processing module; the screening module is arranged below the transmission module; the sputum leading module is connected with the screening module and the kit; and the information processing module is in network connection with external communication equipment. The automatic processing device for realizing virus screening in sputum collection, which is provided by the invention, is used as a direct sputum collection and detection mode, can be widely applied to the detection field of various respiratory viruses, can obviously improve the detection accuracy, the detection speed and the screening proportion, avoids the cross infection risk, is simple, convenient, efficient, economical and applicable, and is suitable for large-scale popularization and application.
Description
Technical Field
The invention relates to the technical field of medical instrument detection, in particular to the technical field of respiratory tract detection equipment, and specifically relates to an automatic processing device for virus screening in sputum collection.
Background
In recent years, a nasopharyngeal swab is mostly adopted in the world to screen epidemic prevention and control modes of new coronary cases. However, this procedure is associated with both nasal itching, throat pain, or nausea which is objectionable, but recent anal swab sampling is more unacceptable.
The existing screening method is difficult to effectively and timely find out the variant virus! And the newly mutated fifth wave super-new coronavirus strain does not live in the rhinitis region of the patient (negative nasal mucosa screening), but shortens the attack time and directly attacks the lung.
The medical experts all consider that the new coronavirus is the largest in the alveoli and sputum, and the screening is the most accurate but not easy to collect.
The mutation of the strain previously improved the infectivity of the new coronavirus by about 9 times! Therefore, it is urgent to provide a new detection method and a new screening device with high sensitivity and high speed, which can detect frequently, inexpensively, quickly and in large quantities, and develop a detection method which is simpler and easier to popularize.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides an automatic processing device for sputum collection and virus screening, which has the advantages of lower cost, smaller structure, simpler and more convenient operation, no wound and convenient use.
In order to achieve the above purpose, an automated processing device for sputum collection and virus screening according to the present invention is as follows:
this an automated processing device for sputum is gathered and is realized virus screening, its key feature is, the device include:
the detection chamber processing module is arranged right in front of the main view of the automatic processing device; the control module is arranged on the inner wall of the detection chamber processing module; the transmission module is arranged at the upper end part of the detection chamber processing module; the screening module is arranged below the transmission module; the sputum leading module is connected with the screening module and the kit; and the information processing module is in network connection with external communication equipment.
Preferably, the detection chamber processing module specifically comprises:
an authentication unit, a disinfection unit and a spraying unit, wherein,
the authentication unit specifically comprises:
the system comprises a touch display screen, an identity card scanning device, an infrared temperature measuring device, an electronic toll collection device, a movable door guide rail and a movable door handle, wherein the touch display screen, the identity card scanning device, the infrared temperature measuring device, the electronic toll collection device and the movable door handle are all arranged on a movable door of a detection chamber processing module, and the movable door is arranged on the movable door guide rail adopting a horizontal double-guide-rail design.
Preferably, the sterilization unit specifically includes:
the device comprises a nano copper wire mesh with the functions of electrifying, heating and sterilizing, an ultraviolet disinfection lamp, a sterilizing and illuminating LED lamp coated with plasma, a first negative pressure exhaust fan and a second negative pressure exhaust fan; wherein, the nano copper wire mesh is stuck in the disposable breathable antiviral non-woven fabric on the inner wall of the automatic processing device; the ultraviolet disinfection lamp is arranged above the transmission module; the first negative pressure exhaust fan is installed at the top of the detection chamber processing module, and the second negative pressure exhaust fan is installed above the transmission module.
Preferably, the spraying unit is provided with a plurality of double rows of spring-pressing type pricker needles, and the spraying unit specifically comprises:
the device and the ink jet device are beaten by spouting of translation formula liquid nozzle and gas nozzle device combination setting, the device setting of beating spout the top of screening module, ink jet device set up the left and right sides of screening module, wherein, the device of beating spout in be provided with first infusion shower nozzle and second infusion shower nozzle, just first infusion shower nozzle and second infusion shower nozzle set up respectively the gas nozzle device's the left and right sides, first infusion shower nozzle and second infusion shower nozzle be arranged in introducing and spraying relevant reagent from the multiunit peristaltic pump, just gas nozzle device introduce from the combination gas pitcher and be used for spraying the amazing gas of trace.
Preferably, the control module specifically includes:
the device comprises a multifunctional button switch, a time counter, a tablet personal computer unit with a voice prompt function, a sensor unit provided with a three-axis gyroscope and a piezoelectric sensor and a lifting unit, wherein the sensor unit is arranged in an armrest of the detection chamber processing module, wherein the armrest is positioned on the front side of the detection chamber processing module; the lifting unit is arranged at the bottom position in the detection chamber processing module and used for a tester to stand, and the lifting unit adopts an electric, pneumatic or hydraulic device structure; the sensor unit and the lifting unit are electrically connected with the tablet personal computer unit.
Preferably, the transmission module specifically includes an input unit and an output unit, wherein,
the input unit is internally provided with a transmission control device, a plurality of groups of peristaltic pumps, a screening accessory access device, a three-dimensional base support and a crawler-type circulating conveyor belt device assembled with a stepping servo system, the transmission control device and the plurality of groups of peristaltic pumps are arranged on the edge of the crawler-type circulating conveyor belt device, and a plurality of three-dimensional bases are respectively arranged at equal intervals and are sequentially arranged on the three-dimensional base support on the crawler-type circulating conveyor belt device; the screening accessory access device guides accessories of the screening module into and installs the accessories on the three-dimensional base support, then transfers the accessories to the three-dimensional base of the input unit separated from the three-dimensional base support after sampling, and finally guides the accessories into the output unit.
Preferably, the output unit specifically includes:
the system comprises a video monitor, an ultraviolet disinfection lamp, a sampling pipe, a first collection box body, a box sealing device, a sampling box, a second collection box body, waste materials and a recovery box body, wherein an output unit is synchronously controlled in a crawler-type circulating conveyor belt device of a stepping servo system through an input unit, and the video monitor, the sampling box, the collection box body, the sampling pipe, the first collection box body and the second collection box body are all arranged on the left side surface and the right side surface of the rear part of the output unit; the recovery box body is arranged at the tail part of the bottom end of the output unit.
Preferably, the automatic processing device further comprises a three-dimensional base, the three-dimensional base is arranged on a three-dimensional base support of the crawler-type circulating transmission crawler device of the input unit and is of a rectangular three-dimensional structure, an elastic boss embedded in the upper surface of the three-dimensional base is arranged at the center of the upper top of the three-dimensional base, each surface of the elastic boss is of a micro-trapezoidal structure, a weighing unit and a vibration unit are arranged in the elastic boss, and the weighing unit and the vibration unit are electrically connected with the control module.
Preferably, the screening module specifically includes: a box cover, a kit, a sample box and a collecting cup;
wherein, the lid include that the front end sets up to 45 oblong through-holes of tilt up, oblong through-hole department cover be equipped with disposable ventilative type antiviral non-woven fabrics, the planar inboard in both sides all be provided with the several round hole about the lid, and the outside is provided with the cylindrical through-hole of several, the middle part of lid be the bellied planar preset position department of rectangle and be provided with a film window that turns over, the left and right sides face of lid all be provided with the switching-over valve and the manual driving lever that are used for carrying out the portable pipeline of giving vent to anger of manual adjustment, the rear end of lid preset position department and be provided with 30 circular jack of tilt up, the bottom of lid set up to the rectangle structure.
Preferably, the reagent box is placed in the box cover, and a dividing layer is arranged at the center of the box cover and the reagent box, and divides the box cover and the reagent box into a preset number of screening areas, so that the box cover and the reagent box can divide the screening number of the sample boxes into structures meeting the detection requirements according to the actual requirements.
Preferably, the structure meeting the detection requirement specifically includes:
the box cover and the reagent box divide the reagent box into a first reagent box cavity, a second reagent box cavity and a third reagent box cavity through the dividing layer, a round hollow pipe is further arranged in the first reagent box cavity, the round hollow pipe is a straight-through hollow pipeline, and the round hollow pipe penetrates through the box cover;
the first cavity of the kit is used for collecting viral nucleic acid in sputum; the second cavity of the kit and the third cavity of the kit are used for collecting virus antibodies in sputum.
Preferably, a sleeving concave table is arranged at the central position of the lower bottom of the kit, and the elastic boss of the three-dimensional base is assembled with the sleeving concave table, so that the three-dimensional base and the kit are assembled together; the edge positions of the left side and the right side of the bottom of the kit are respectively provided with a buckle, a plug interface and a threaded interface in a row, and the buckle, the plug interface and the threaded interface are all used for fixedly mounting the sample box.
Preferably, the sample box comprises a sample box and a sample tube, wherein the sample box is a rectangular box body, the upper end of the sample box is open, a notch is arranged on the inner side of the open, a hollow transparent body matched with the buckle is arranged on the outer edge of the open, a vertically inserted colloidal gold test strip is arranged in the rectangular box body, a strip-shaped rectangular box cover is arranged, and the sample tube is a circular sample tube with external threads and is also provided with a tube cover matched with the circular sample tube.
Preferably, the sampling cup is inserted into the circular insertion hole of the box cover, the sampling cup comprises a conical hollow cup body which is pressed by a high-molecular water-absorbing material and is used for blowing, absorbing and removing thin saliva and collecting thick sputum, and the cup cover of the sampling cup pushes and scrapes the thick sputum to slide into the kit after the sputum is collected from the sampling cup.
Preferably, the sputum aspirating module specifically comprises: a translational phlegm eliminating unit and a phlegm urging unit; wherein the content of the first and second substances,
the translation type phlegm eliminating unit specifically comprises: the device comprises a first air outlet pipe, a second air outlet pipe provided with a whistle vibrator, an air pressure regulator and a translation type vibrating sputum discharging device, a first sterilizing unit and a second sterilizing unit, wherein the first sterilizing unit and the second sterilizing unit are provided with sterilizing and illuminating LED lamps coated with plasma, and the side surfaces of the first air outlet pipe and the second air outlet pipe are provided with a reversing valve and a manual driving lever of a movable air outlet pipeline for manual regulation.
Preferably, the sputum excretion unit specifically comprises:
the combined gas tank is filled with various pungent smells, the control gas valve, the gas pipe gas circuit and the nozzle which correspond to the combined gas tank, the combined gas tank and the corresponding control gas valve are arranged on the movable spraying device, and the connecting gas pipe and the nozzle of the combined gas tank and the control gas valve are arranged in the movable spraying device.
Preferably, the information processing module comprises a monitoring device, a data processing unit and an external communication device, wherein the monitoring device is used for sending the collected sputum collection information of the detector to the data processing unit for data processing, and sending the processing result to the external communication device through a network.
The automatic processing device for sputum collection and virus screening is used as a noninvasive, efficient, economical, portable and convenient direct sputum collection and detection mode, can be widely applied to the field of antigen-antibody detection of various respiratory viruses, obviously improves the accuracy and detection speed of detection results according to clinical test data, screens patients in asymptomatic or early disease stage, and avoids the risk of cross infection. Meanwhile, the device is suitable for operation and carrying, simple, convenient, efficient, economical and durable in production and manufacture, and is suitable for large-scale popularization and application.
Meanwhile, the invention adopts a non-invasive, easy and efficient sampling mode, can be used for detecting antibodies of new coronavirus (various pneumonia), can directly upload detected data, can be left by patients, avoids contacting other infected patients, and reduces the risk of infection of medical staff.
Drawings
Fig. 1 is a schematic front view of the automated processing device for sputum collection and virus screening according to the present invention.
Fig. 2 is a schematic structural diagram of the disposable mask worn by the automated processing device for sputum collection and virus screening according to the present invention.
Fig. 3 is a schematic structural diagram of a collection cup of the automated processing device for sputum collection and virus screening according to the present invention.
Fig. 4 is a left-side view structural schematic diagram of the automatic processing device for sputum collection and virus screening according to the present invention.
Fig. 5 is a schematic structural diagram of the automated processing device for sputum collection and virus screening according to the present invention, which includes an output unit, a first collection box, a monitoring unit, a second collection box, and a recovery box.
Fig. 6 is a schematic structural diagram of a three-dimensional base of the automatic processing device for sputum collection and virus screening according to the present invention.
Fig. 7-1 is a schematic front view of the kit of the automated processing device for sputum collection to realize virus screening according to the present invention.
Fig. 7-2 is a schematic inverted structure diagram of the kit of the automated processing device for sputum collection and virus screening according to the present invention.
Fig. 8 is a schematic top perspective view of the kit of the automated processing device for sputum collection and virus screening according to the present invention.
Fig. 9 is a schematic assembly structure diagram of the kit of the automated processing device for sputum collection and virus screening according to the present invention.
FIG. 10 is a schematic view of an assembly structure of the cartridge of the automated processing device for sputum collection and virus screening according to the present invention.
Fig. 11 is a schematic view of an assembly structure between an air outlet channel and a box cover of the automatic processing device for sputum collection and virus screening according to the present invention.
Reference numerals
1 detection chamber processing module
2 electronic toll device
3 infrared temperature measuring device
4 ID card scanning device
5 touch display screen
6 move the door handle
7 moving door
8 sliding door guide rail
9 nanometer copper wire mesh
10 ultraviolet sterilizing lamp
11 first negative pressure exhaust fan
12 spraying device
13 screening module
14 collecting cup
15 Disposable mask
Ear belt of 16 disposable mask
17 ink jet device
18 sensor unit
19 triaxial gyroscope and piezoelectric sensor
20 crawler-type circulation conveyer belt device
21 lifting unit
22 first infusion nozzle
23 gas nozzle device
24 second infusion nozzle
25-pressing elastic type puncture needle
26 Transmission control device
27 multigroup peristaltic pump
28 second negative pressure exhaust fan
29 translational phlegm eliminating unit
30 combination gas tank
31 screening accessory access device
32 three-dimensional base support
33 input unit
34 output unit
35 video monitoring instrument
36 sampling tube
37 first collection tank
38 sampling box
39 second collection box
40 waste material
41 recovery box
42 three-dimensional base
43 elastic boss
44 weighing cell
45 vibration unit
46 case cover
47 film turnover window
48 reversing valve and manual deflector rod
49 oblong through hole
50 disposable ventilative type antiviral non-woven fabrics
51 round hole
52 cylindrical through hole
53 round jack
54 divided layer
55 kit
56 fastener
57 interface
58 socket joint concave station
59 threaded joint
60 circular hollow pipe
61 first cavity of reagent kit
62 second cavity of reagent kit
63 third cavity of reagent kit
64 flat and long sampling box
65 colloidal gold sample strip
66 strip-shaped rectangular box cover
67 first air outlet pipe
68 second air outlet pipe
69 air pressure regulator
70 second killing unit
71 first killing unit
Detailed Description
In order to more clearly describe the technical contents of the present invention, the following further description is given in conjunction with specific embodiments.
Before explaining embodiments in accordance with the present invention in detail, it should be noted that first and second like relational terms are used hereinafter only to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. The terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Referring to fig. 1, the automated processing device for virus screening in sputum collection includes:
a detection chamber processing module 1, which is arranged right in front of the main view of the automatic processing device; the control module is arranged on the inner wall of the detection chamber processing module 1; a transmission module arranged at the upper end of the detection chamber processing module 1; the screening module 13 is arranged below the transmission module; the sputum leading module is connected with the screening module 13 and the kit; and the information processing module is in network connection with external communication equipment.
As a preferred embodiment of the present invention, the detection chamber processing module 1 specifically comprises:
an authentication unit, a disinfection unit and a spraying unit, wherein,
the authentication unit specifically comprises:
the system comprises a touch display screen 5 with detection setting and video authentication functions, an identity card scanning device 4, an infrared temperature measuring device 3, an electronic toll collection device 2, a movable door guide rail 8 and a movable door handle 6, wherein the touch display screen 5, the identity card scanning device 4, the infrared temperature measuring device 3, the electronic toll collection device 2 and the movable door handle 6 are all arranged on a movable door 7 of a detection chamber processing module 1, and the movable door 7 is arranged on the movable door guide rail 8 which adopts a horizontal double-guide-rail design.
As a preferred embodiment of the present invention, the sterilization unit specifically includes:
the device comprises a nano copper wire mesh 9 with the functions of electrifying, heating and sterilizing, an ultraviolet disinfection lamp 10, a sterilizing and lighting LED lamp coated with plasma, a first negative pressure exhaust fan 11 and a second negative pressure exhaust fan 28; wherein, the nano copper wire mesh 9 is stuck in the disposable breathable antiviral non-woven fabric 50 on the inner wall of the automatic processing device; the ultraviolet disinfection lamp 10 is arranged above the transmission module; the first negative pressure exhaust fan 11 is installed at the top of the detection chamber processing module 1, and the second negative pressure exhaust fan 28 is installed above the transmission module.
As a preferred embodiment of the present invention, the spraying unit is provided with a plurality of bullet pressing type pricking pins 25 in two rows, which specifically includes:
the device comprises a jet device 12 and an ink jet device 17 which are combined by a translational liquid nozzle and a gas nozzle device 23, wherein the jet device 12 is arranged above the screening module 13, the ink jet device 17 is arranged on the left side and the right side of the screening module 13, a first infusion sprayer 22 and a second infusion sprayer 24 are further arranged in the jet device 12, the first infusion sprayer 22 and the second infusion sprayer 24 are respectively arranged on the left side and the right side of the gas nozzle device 23, the first infusion sprayer 22 and the second infusion sprayer 24 are used for introducing and spraying related reagents from a plurality of groups of peristaltic pumps 27, and the gas nozzle device 23 is introduced from a combined gas tank 30 and used for spraying a trace amount of irritant gas.
As a preferred embodiment of the present invention, the control module specifically includes:
the multifunctional detection device comprises a multifunctional button switch, a time counter, a tablet personal computer unit with a voice prompt function, a sensor unit 18 provided with a three-axis gyroscope and a piezoelectric sensor 19, and a lifting unit 21, wherein the sensor unit 18 is arranged in an armrest of the detection chamber processing module 1 on the front side; the lifting unit 21 is arranged at the bottom position in the detection chamber processing module 1 and is used for a tester to stand, and the lifting unit 21 adopts an electric, pneumatic or hydraulic device structure; the sensor unit 18 and the lifting unit 21 are electrically connected with the tablet computer unit.
As a preferred embodiment of the present invention, the transmission module specifically comprises an input unit 33 and an output unit 34, wherein,
the input unit 33 is internally provided with a transmission control device 26, a plurality of groups of peristaltic pumps 27, a screening accessory access device 31, a three-dimensional base support 32 and a crawler-type circulating conveyor belt device 20 assembled with a stepping servo system, the transmission control device 26 and the plurality of groups of peristaltic pumps 27 are arranged at the edge of the crawler-type circulating conveyor belt device 20, and a plurality of three-dimensional bases 42 are respectively arranged at equal intervals and are sequentially arranged on the three-dimensional base support 32 on the crawler-type circulating conveyor belt device 20; the screening accessory access device 31 guides and installs the accessories of the screening module 13 on the three-dimensional base 42 of the three-dimensional base support 32, transfers the sampled accessories to the three-dimensional base 42 of the input unit 33 separated from the three-dimensional base support 32, and finally guides the sampled accessories to the output unit 34.
As a preferred embodiment of the present invention, the output unit 34 specifically includes:
the device comprises a video monitor 35, an ultraviolet disinfection lamp 10, a sampling pipe 36, a first collection box body 37, a box sealing device, a sampling box 38, a second collection box body 39, waste materials 40 and a recovery box body 41, wherein an output unit 34 is synchronously controlled in a crawler-type circulating conveyor belt device 20 of a stepping servo system through an input unit 33, and the video monitor 35, the sampling box 38, the sampling pipe 36, the first collection box body 37 and the second collection box body 39 are all arranged on the left side surface and the right side surface of the rear part of the output unit 34; the recycling box 41 is disposed at the bottom end of the output unit 34.
As a preferred embodiment of the present invention, the automatic processing apparatus further includes a three-dimensional base 42, the three-dimensional base 42 is disposed on the three-dimensional base support 32 of the endless belt conveyor 20 of the input unit 33 and has a rectangular three-dimensional structure, an elastic boss 43 embedded on the upper surface of the three-dimensional base is disposed at a central position of an upper top portion of the three-dimensional base 42, each surface of the elastic boss 43 is configured to have a micro-trapezoidal structure, a weighing unit 44 and a vibration unit 45 are disposed in the elastic boss 43, and the weighing unit 44 and the vibration unit 45 are electrically connected to the control module.
Referring to fig. 3, as a preferred embodiment of the present invention, the screening module 13 specifically includes: a box cover 46, a reagent box 55, a sample box and a collection cup 14;
wherein, lid 46 include that the front end sets up to 45 oblong through-hole 49 of tilt up, oblong through-hole 49 department cover be equipped with disposable ventilative type antiviral non-woven fabrics 50, the planar inboard of the left and right sides of lid 46 all be provided with several round hole 51, and the outside is provided with the cylindrical through-hole 52 of several, the middle part of lid 46 be that the bellied planar preset position department of rectangle is provided with a film and turns over window 47, the left and right sides face of lid 46 all be provided with the switching-over valve and the manual driving lever 48 that are used for carrying out the portable pipeline of giving vent to anger of manual adjustment, the preset position department of the rear end of lid 46 be provided with 30 circular jack 53 of tilt up, the bottom of lid 46 set up to the rectangle structure.
Referring to fig. 7-1 to 8, as a preferred embodiment of the present invention, the reagent box 55 is placed in the box cover 46, and a dividing layer 54 is disposed at the center of the box cover 46 and the reagent box 55, the dividing layer 54 divides the box cover 46 and the reagent box 55 into a predetermined number of screening areas, so that the box cover 46 and the reagent box 55 divide the screening number of the sample boxes into structures meeting the detection requirements according to the actual requirements.
Referring to fig. 8, as a preferred embodiment of the present invention, the structure meeting the detection requirement specifically includes:
the box cover 46 and the reagent box 55 divide the reagent box 55 into a first reagent box cavity 61, a second reagent box cavity 62 and a third reagent box cavity 63 through the dividing layer 54, a circular hollow pipe 60 is further arranged in the first reagent box cavity 61, the circular hollow pipe 60 is a straight hollow pipeline, and the circular hollow pipe 60 is arranged to penetrate through the box cover 46; the circular hollow tube 60 shown in fig. 8 is a virtual illustration only for convenience of corresponding view.
The first cavity 61 of the kit is used for collecting viral nucleic acid in sputum; the second cavity 62 and the third cavity 63 of the kit are used for collecting virus antibodies in sputum.
Referring to fig. 7-1 to 9, as a preferred embodiment of the present invention, a set of receiving recessed table 58 is disposed at a central position of a lower bottom of the reagent cartridge 55, and the elastic protrusion 43 of the three-dimensional base 42 is assembled with the set of receiving recessed table 58, so that the three-dimensional base 42 and the reagent cartridge 55 are assembled together; the edge positions of the left side and the right side of the bottom of the reagent kit 55 are respectively provided with a buckle 56, a socket 57 and a threaded interface 59 in a row, and the buckle 56, the socket 57 and the threaded interface 59 are all used for fixedly mounting the sample kit.
Referring to fig. 10, as a preferred embodiment of the present invention, the sample box specifically includes a flat and long sample box 64 and a sample tube 36, wherein the flat and long sample box 64 is a rectangular box body, the upper end of the flat and long sample box is provided with an opening, the inside of the opening is provided with a notch, the outer edge of the opening is provided with a hollow transparent body adapted to the buckle 56, a vertically inserted colloidal gold sample strip 65 and a strip-shaped rectangular box cover 66 are arranged in the rectangular box body, and the sample tube 36 is configured as a circular sample tube with external threads and is further equipped with a tube cover matched with the circular sample tube.
As a preferred embodiment of the present invention, the collection cup 14 is inserted into the circular insertion hole 53 of the box cover 46, and the collection cup 14 includes a conical hollow cup body 14-1 which is pressed by a high molecular water absorbing material and is used for blowing, absorbing and removing thin saliva and collecting thick sputum, and after the sputum is collected from the collection cup 14, the cup cover 14-2 of the collection cup 14 pushes and scrapes the thick sputum to slide into the reagent kit 55.
As a preferred embodiment of the present invention, the sputum aspirating module specifically includes: a translational phlegm eliminating unit 29 and a phlegm urging unit; wherein the content of the first and second substances,
the translational phlegm eliminating unit 29 specifically comprises: the first air outlet pipe 67, the second air outlet pipe 68 provided with the whistle vibrator and the air pressure regulator 69 and the translation type vibrating sputum exhauster, the first sterilizing unit 71 and the second sterilizing unit 70 provided with the plasma-coated sterilizing and illuminating LED lamp, and the side surfaces of the first air outlet pipe 67 and the second air outlet pipe 68 are provided with the reversing valve of the movable air outlet pipeline for manual adjustment and the manual deflector rod 48.
As a preferred embodiment of the present invention, the sputum excretion unit specifically comprises:
the combined gas tank 30 filled with various pungent smells, the control gas valve corresponding to the combined gas tank 30, the gas pipe gas circuit and the nozzle, wherein the combined gas tank 30 and the corresponding control gas valve are both arranged on the movable spraying device 12, and the connecting gas pipe and the nozzle of the combined gas tank 30 and the control gas valve are both arranged in the movable spraying device 12.
As a preferred embodiment of the present invention, the information processing module includes a monitoring device, a data processing unit, and an external communication device, wherein the monitoring device is configured to send collected sputum collection information of the examiner to the data processing unit for data processing, and send a processing result to the external communication device through a network.
In one embodiment of the present invention, the reagent strip used in the test kit of the present invention is specifically:
1. reagent strip for detecting COVID-19 antigen (colloidal gold method) and
2. the reagent strip for detecting the influenza A/B virus antigen (colloidal gold method) comprises the following specific using modes:
the sampling kit comprises a pvc bottom plate, a sample pad, a sputum filtering pad, a combination pad, a nitrocellulose membrane and absorbent paper, wherein the sample pad, the blood filtering pad, the combination pad, the nitrocellulose membrane and the absorbent paper are sequentially and mutually staggered and lapped and then are adhered to the pvc bottom plate, and the sampling kit is obtained after insertion.
In one embodiment of the present invention, the liquid reagent used in the test kit of the present invention specifically includes: reagent 1 adopts a new coronavirus transport medium (VTM); the reagent 2 adopts inactivated virus transport medium (VTM-N); the reagents 3, 4, 5, 6 and 7 are virus lysates.
In one embodiment of the present invention, the gold reagent strip used in the cartridge of the present invention is as follows:
3. COVID-19 antigen detection kit (colloidal gold method)
4. Novel influenza A H1N1 virus (colloidal gold method)
5. Mycoplasma pneumoniae antigen detection kit (colloidal gold method)
6. Influenza A/B virus antigen detection kit (colloidal gold method)
7. Respiratory syncytial virus antigen detection kit (colloidal gold method)
In one embodiment of the present invention, the sampling tube used in the test kit of the present invention is a disposable sample transport tube, and the sampling tube uses an inlet polypropylene tube body and a polyethylene cover, and the tube body has a height of 87mm, so that the collected sample can be transported safely and effectively.
In a specific embodiment of the invention, the test kit provided by the invention has the advantages of convenience in operation, direct visual interpretation, high detection speed (10 to 15 minutes), high specificity, easiness in popularization and the like by collecting deep cough sputum in a disposable sterile screw cap sampling kit and marking by adopting a colloidal gold method.
In a specific embodiment of the invention, the double-antigen sandwich detection total antibody is adopted, so that the method not only has the advantages of early diagnosis of the novel coronavirus through IgM antibody detection, but also has the characteristics of detecting the prior infection (including a patient with decreased IgM in the recovery phase) of the IgG antibody, can better prevent omission, shorten the diagnosis window period, has higher specificity and sensitivity, saves the operation time and cost, is convenient and quick, reduces the cross contamination and other advantages, and has important value in novel coronavirus detection!
As a specific embodiment of the invention, by replacing the reagent, the device can be expanded to the subdivided fields of infectious disease detection (such as respiratory infectious diseases, AIDS, viral hepatitis and the like), chronic disease management, tumor diagnosis and treatment and the like in the future, and more detection items are promoted to realize rapidness and convenience.
In a specific embodiment of the invention, by replacing the reagent, the fields of hepatitis B antibody, syphilis antibody [1], HIV antibody [2], hepatitis C antibody [3] and the like can be detected successfully, and the detection of the AIDS antibody is realized from an indirect method to a fourth generation of detection by a double-antigen sandwich method.
In a specific embodiment of the invention, the VTM-N preservation solution can be used for quickly inactivating viruses, but the complete nucleic acid fragment can be preserved at room temperature for more than 1 month, and the sensitivity of subsequent nucleic acid detection can still be ensured. Although this sample cannot be used for culturing and isolating viruses, it can ensure safety in transporting the sample.
In one embodiment of the invention, the sample provided by the preservation solution is basically live virus, so that the originality of the sample can be maintained to the maximum extent, and the sample can be subsequently used for not only nucleic acid extraction and detection of the virus, but also culture and separation of the virus. For detection, it should be noted that the nucleic acid must be purified by extraction after inactivation.
As a specific embodiment of the invention, the input unit is used as a structure comprising a mouth, a screw plug pressure regulating manual control one-way valve and a vibration ball sputum aspirator, when the input unit is connected with the vibration ball sputum aspirator, the airway of a user can vibrate to generate severe cough to loosen secretion in the airway by the principle of acting force and reacting force, so that thick sputum adhered to the airway is loosened and easy to discharge (has the same sputum discharging function as the vibration sputum aspirator), the loosened secretion is pushed into a large airway at the upper part from bottom to top, the lung environment is improved, the secretion is favorably coughed, the air retention is reduced, and the respiratory function of the lung is improved. When the user feels that the sputum can be spitted, the plug screw pressure regulating manual control one-way valve is immediately adjusted to be in a straight-through state, so that the discharging of the breath and the air resistance in the screening box are facilitated when the user coughs and spits.
The technical scheme adopts polyethylene-propylene polymer (Polyallemer) plastic and certain specially processed Polypropylene (Polypropylene) plastic to manufacture the sampling container, and the sampling container is more suitable for storage and subsequent use of samples.
Meanwhile, the automatic processing device for sputum collection and virus screening provided by the invention has the following relevant requirements when collecting sputum as shown in the following table 1:
the automatic processing device for sputum collection and virus screening has the following effects as shown in the following table 2:
reference throughout this specification to the description of "an embodiment," "some embodiments," "an example," "a specific example," "an implementation" or "an embodiment," or the like, means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art within the scope of the present invention.
The test box for realizing virus screening and sputum collection virus screening is used as a noninvasive, efficient, economical and portable sputum collection and detection mode convenient for home direct collection and detection, can be widely applied to the field of antigen-antibody detection of various respiratory viruses, and obviously improves the accuracy and detection speed of detection results and screening proportion of asymptomatic or early-stage disease patients according to clinical test data, thereby avoiding the risk of cross infection. Meanwhile, the device is suitable for operation and carrying, simple, convenient, efficient, economical and durable in production and manufacture, and is suitable for large-scale popularization and application.
Meanwhile, the invention adopts a non-invasive, easy and efficient sampling mode, can be used for detecting antibodies of new coronavirus (various pneumonia), can directly upload detected data, can be left by patients, avoids contacting other infected patients, and reduces the risk of infection of medical staff.
In this specification, the invention has been described with reference to specific embodiments thereof. It will, however, be evident that various modifications and changes may be made thereto without departing from the broader spirit and scope of the invention. The specification and drawings are, accordingly, to be regarded in an illustrative rather than a restrictive sense.
Claims (13)
1. An automated processing device for virus screening in sputum collection, the device comprising:
the detection chamber processing module (1) is arranged right in front of the main view of the automatic processing device; the control module is arranged on the inner wall of the detection chamber processing module (1); the transmission module is arranged at the upper end part of the detection chamber processing module (1); the screening module (13) is arranged below the transmission module; the sputum leading module is connected with the screening module (13) and the kit; the information processing module is connected with external communication equipment through a network; the detection chamber processing module (1) specifically comprises:
an authentication unit, a disinfection unit and a spraying unit, wherein,
the authentication unit specifically comprises:
the system comprises a touch display screen (5) with detection setting and video authentication functions, an identity card scanning device (4), an infrared temperature measuring device (3), an electronic toll collection device (2), a movable door guide rail (8) and a movable door handle (6), wherein the touch display screen (5), the identity card scanning device (4), the infrared temperature measuring device (3), the electronic toll collection device (2) and the movable door handle (6) are all arranged on a movable door (7) of a detection room processing module (1), and the movable door (7) is arranged on the movable door guide rail (8) adopting a horizontal double-guide-rail design;
the unit of beating in be provided with a plurality of pressure bullet type felting needles of double row (25), specifically include:
a jet device (12) and an ink jet device (17) which are combined by a translation type liquid nozzle and a gas nozzle device (23), the spraying device (12) is arranged above the screening module (13), the ink jet device (17) is arranged at the left side and the right side of the screening module (13), wherein the spraying device (12) is also provided with a first transfusion spray head (22) and a second transfusion spray head (24), and the first liquid-delivery nozzle (22) and the second liquid-delivery nozzle (24) are respectively arranged at the left side and the right side of the gas nozzle device (23), the first infusion nozzle (22) and the second infusion nozzle (24) are used for introducing and spraying reagents from a plurality of groups of peristaltic pumps (27), and the gas nozzle device (23) is used for introducing stimulating gas for spraying trace amount from the combined gas tank (30);
the screening module (13) specifically comprises: a box cover (46), a reagent box (55), a sample box and a collection cup (14); the sample box specifically comprises a flat-long type sampling box (64) and a sampling tube (36), wherein the sampling tube (36) adopts an inlet polypropylene tube body and a polyethylene cover, and the tube body is 87mm high and is used for safely and effectively transferring the collected sample;
the anti-virus box comprises a box cover (46), wherein the front end of the box cover (46) comprises an oblong through hole (49) which is upwards inclined by 45 degrees, a disposable breathable anti-virus non-woven fabric (50) is sleeved at the position of the oblong through hole (49), a plurality of round holes (51) are formed in the inner sides of the planes of the left side and the right side of the box cover (46), a plurality of cylindrical through holes (52) are formed in the outer sides of the oblong through hole, a film turning window (47) is arranged at a preset position of the plane of the rectangular bulge in the middle of the box cover (46), reversing valves and manual deflector rods (48) of a movable air outlet pipeline for manual adjustment are arranged on the left side and the right side of the box cover (46), a circular insertion hole (53) which is upwards inclined by 30 degrees is formed in the preset position of the rear end of the box cover (46), and a rectangular structure is arranged at the bottom of the box cover (46);
the reagent box (55) is placed in the box cover (46), the center positions of the box cover (46) and the reagent box (55) are provided with a dividing layer (54), the dividing layer (54) divides the box cover (46) and the reagent box (55) into screening areas with preset number, and the dividing layer is used for dividing the screening number of the sample box into structures meeting the detection requirement according to the actual requirement by the box cover (46) and the reagent box (55).
2. The automated processing device for sputum collection and virus screening as claimed in claim 1, wherein the disinfection unit specifically comprises:
the ultraviolet disinfection lamp comprises a nanometer copper wire mesh (9) with the functions of electrifying, heating and sterilizing, an ultraviolet disinfection lamp (10), a sterilizing and lighting LED lamp coated with plasma, a first negative pressure exhaust fan (11) and a second negative pressure exhaust fan (28); wherein, the nano-copper wire mesh (9) is stuck in the disposable breathable antiviral non-woven fabric (50) on the inner wall of the automatic processing device; the ultraviolet disinfection lamp (10) is arranged above the transmission module; first negative pressure exhaust fan (11) install the top of detection room processing module (1), second negative pressure exhaust fan (28) install the top of transmission module.
3. The automated processing device for sputum collection and virus screening as claimed in claim 2, wherein the control module specifically comprises:
the multifunctional detection chamber comprises a multifunctional button switch, a time counter, a tablet personal computer unit with a voice prompt function, a sensor unit (18) provided with a three-axis gyroscope and a piezoelectric sensor (19), and a lifting unit (21), wherein the sensor unit (18) is arranged in an armrest of the detection chamber processing module (1) on the front side; the lifting unit (21) is arranged at the bottom position in the detection chamber processing module (1) and is used for a tester to stand, and the lifting unit (21) adopts an electric, pneumatic or hydraulic device structure; the sensor unit (18) and the lifting unit (21) are electrically connected with the tablet personal computer unit.
4. The automated processing device for sputum collection and virus screening according to claim 3, wherein the transmission module comprises an input unit (33) and an output unit (34), wherein,
the automatic screening device is characterized in that a transmission control device (26), a plurality of groups of peristaltic pumps (27), a screening accessory access device (31), a three-dimensional base support (32) and a crawler-type circulating conveying belt device (20) provided with a stepping servo system are arranged in the input unit (33), the transmission control device (26) and the plurality of groups of peristaltic pumps (27) are installed on the edge of the crawler-type circulating conveying belt device (20), the three-dimensional bases (42) are arranged at equal intervals respectively and are sequentially installed on the three-dimensional base support (32) on the crawler-type circulating conveying belt device (20); the screening accessory access device (31) guides accessories of the screening module (13) into the three-dimensional base (42) on the three-dimensional base support (32), transfers the sampled accessories onto the three-dimensional base (42) of the input unit (33) separated from the three-dimensional base support (32), and finally guides the sampled accessories into the output unit (34).
5. The automated processing device for sputum collection and virus screening as claimed in claim 4, wherein the output unit (34) specifically comprises:
the device comprises a video monitor (35), an ultraviolet disinfection lamp (10), a sampling tube (36), a first collection box body (37), a box sealing device, a sampling box (38), a second collection box body (39), waste materials (40) and a recovery box body (41), wherein an output unit (34) is synchronously controlled in a crawler-type circulating transmission belt device (20) of a stepping servo system through an input unit (33), and the video monitor (35), the sampling box (38), the sampling tube (36), the first collection box body (37) and the second collection box body (39) are all arranged on the left side surface and the right side surface of the rear part of the output unit (34); the recovery box body (41) is arranged at the tail part of the bottom end of the output unit (34).
6. The automated processing device for sputum collection for screening viruses of claim 5, characterized in that the automatic processing device also comprises a three-dimensional base (42), the three-dimensional base (42) is arranged on a three-dimensional base bracket (32) of a crawler-type circulating conveying belt device (20) of the input unit (33), the structure is a rectangular three-dimensional structure, an elastic lug boss (43) embedded on the upper surface of the three-dimensional base is arranged at the central position of the upper top of the three-dimensional base (42), each surface of the elastic lug boss (43) is of a micro-trapezoidal structure, and a weighing unit (44) and a vibration unit (45) are arranged in the elastic boss (43), the weighing unit (44) and the vibration unit (45) are electrically connected with the control module.
7. The automated processing device for sputum collection and virus screening according to claim 1, wherein the structure meeting the detection requirement is specifically:
the box cover (46) and the reagent box (55) divide the reagent box (55) into a first reagent box cavity (61), a second reagent box cavity (62) and a third reagent box cavity (63) through the dividing layer (54), a round hollow pipe (60) is further arranged in the first reagent box cavity (61), the round hollow pipe (60) is a straight-through hollow pipeline, and the round hollow pipe (60) is arranged to penetrate through the box cover (46);
the first cavity (61) of the kit is used for collecting viral nucleic acid in sputum; the second cavity (62) and the third cavity (63) of the kit are used for collecting virus antibodies in the sputum.
8. The automatic processing device for sputum collection and virus screening according to claim 4, wherein a set of receiving concave platform (58) is provided at a central position of a lower bottom of the reagent box (55), and the elastic boss (43) of the three-dimensional base (42) is assembled with the set of receiving concave platform (58), so that the three-dimensional base (42) and the reagent box (55) are assembled together; the edge positions of the left side and the right side of the bottom of the kit (55) are respectively provided with a buckle (56), an inserting port (57) and a threaded interface (59) in a row, and the buckle (56), the inserting port (57) and the threaded interface (59) are all used for fixedly mounting the sample box.
9. The automated processing device for screening viruses in sputum collection according to claim 8, wherein the elongated sampling box (64) is a rectangular box body, the upper end of the elongated sampling box is open, a notch is arranged inside the open, the outer edge of the open is provided with a hollow transparent body matched with the buckle (56), a vertically inserted colloidal gold test strip (65) and a strip-shaped rectangular box cover (66) are arranged in the rectangular box body, and the sampling tube (36) is a round sampling tube with external threads and is also provided with a tube cover matched with the round sampling tube.
10. The automatic processing device for sputum collection and virus screening according to claim 1, wherein the collection cup (14) is inserted into the circular insertion hole (53) of the box cover (46), the collection cup (14) comprises a conical hollow cup body (14-1) which is pressed by a high molecular water-absorbing material and is inserted for blowing, absorbing and removing thin saliva and collecting thick sputum, and the cup cover (14-2) of the collection cup (14) pushes and scrapes the thick sputum to slide into the reagent box (55) after the sputum collection from the collection cup (14) is completed.
11. The automated processing device for sputum collection and virus screening as claimed in claim 1, wherein the sputum aspirating module specifically comprises: a translational phlegm eliminating unit (29) and a phlegm inducing unit; wherein the content of the first and second substances,
the translational phlegm eliminating unit (29) specifically comprises: first outlet duct (67), install whistle vibrator, air pressure regulator (69) and translation formula vibration sputum discharging ware second outlet duct (68), set up and coat first killing unit (71) and the second unit (70) that kills and kill of disinfecting illumination LED lamp that has plasma, just the side of first outlet duct (67) and second outlet duct (68) all be provided with the switching-over valve and the manual driving lever (48) of the portable outlet duct who carries out manual adjustment.
12. The automated processing device for sputum collection and virus screening as claimed in claim 11, wherein the sputum-aspirating unit specifically comprises:
the combined gas tank (30) filled with various pungent smells, the control gas valve corresponding to the combined gas tank (30), the gas pipe gas circuit and the nozzle are arranged on the movable spraying device (12), and the connecting gas pipe and the nozzle of the combined gas tank (30) and the control gas valve are arranged in the movable spraying device (12).
13. The automated processing device for sputum collection and virus screening according to any one of claims 1 to 12, wherein the information processing module comprises a monitoring device, a data processing unit and an external communication device, the monitoring device is configured to send collected sputum collection information of the examiner to the data processing unit for data processing, and send the processing result to the external communication device through a network.
Priority Applications (1)
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CN202110890486.0A CN113466455B (en) | 2021-08-04 | 2021-08-04 | Automatic processing device for virus screening in sputum collection |
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CN202110890486.0A CN113466455B (en) | 2021-08-04 | 2021-08-04 | Automatic processing device for virus screening in sputum collection |
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