CN215894640U

CN215894640U - Utilize sputum to carry out wearable device of nucleic acid sampling and be used for sputum to gather and realize wearable testing arrangement of virus screening

Info

Publication number: CN215894640U
Application number: CN202121804066.8U
Authority: CN
Inventors: 张佩刚
Original assignee: Shenzhen Hengha Biotechnology Co ltd
Current assignee: Shenzhen Hengha Biotechnology Co ltd
Priority date: 2021-08-04
Filing date: 2021-08-04
Publication date: 2022-02-22
Anticipated expiration: 2031-08-04

Abstract

The utility model relates to a wearable device for sampling nucleic acid by using sputum, which comprises a box cover, a sampling cup, a sampling tube and a wearable unit, wherein the sampling cup is inserted and arranged on the box cover, the box cover is screwed and arranged on the sampling tube, the wearable unit is sleeved and arranged on the wearable device, and the box cover, the sampling cup and the sampling tube are inserted and arranged in the wearable device. The utility model also relates to a corresponding wearable test device for realizing virus screening. The wearable device for sampling nucleic acid by using sputum and the wearable test device for realizing virus screening provided by the utility model provide a noninvasive, efficient, economical and portable sputum collection and detection mode convenient for home use, can be widely applied to the field of antigen-antibody detection of various respiratory viruses, has the advantages of simple and efficient production and manufacture, economy and durability, and is suitable for large-scale popularization and application.

Description

Utilize sputum to carry out wearable device of nucleic acid sampling and be used for sputum to gather and realize wearable testing arrangement of virus screening

Technical Field

The utility model relates to the technical field of medical instrument detection, in particular to the technical field of respiratory tract detection equipment, and specifically relates to a wearable device for nucleic acid sampling by using sputum and a wearable test device for virus screening by sputum collection.

Background

At present, nasopharyngeal swabs are mostly adopted globally for screening new coronary cases. However, the newly mutated fifth wave super-new coronavirus strain does not live in the rhinitis region of the patient (negative nasal mucosa screening), but directly attacks the lung after the attack time is shortened. Therefore, there are currently 11 cases in question that are negative in nucleic acid detection, and positive cases of new coronaviruses are not detected until the twelfth screening. Evidence that current screening methods have difficulty finding variant viruses in a timely and effective manner!

In the sixth and seventh diagnostic standards for new coronary pneumonia released in 19.2.2020, particularly, "in order to improve the positive rate of nucleic acid detection, it is recommended to leave sputum as much as possible, collect the lower respiratory secretions of patients with tracheal intubation, and send samples for examination as soon as possible".

Therefore, it is urgent to provide a frequent, low-cost, fast and large-scale virus screening method, a new detection method and a screening device with high sensitivity and high speed, and to develop a detection method which is simpler and easier to popularize.

SUMMERY OF THE UTILITY MODEL

The utility model aims to overcome the defects of the prior art and provides a wearable device which is lower in cost, smaller in structure, simpler and more convenient to operate, is not invasive and can be randomly used for sampling nucleic acid by using sputum and a wearable test device for realizing virus screening by sputum collection.

In order to achieve the above purpose, the wearable device for nucleic acid sampling by sputum and the wearable test device for virus screening by sputum collection of the utility model are as follows:

this utilize sputum to carry out wearable device of nucleic acid sampling, its key feature is, wearable device include lid, sampling cup, sampling tube and wearable unit, wherein, sampling cup peg graft and set up the lid on, the lid connect the setting soon to be in the sampling tube on, wearable unit cup joint the setting and be in wearable device on, just lid, sampling cup, sampling tube between peg graft the installation back each other, all set up wearable device in.

Preferably, the lid be spiral cover formula tee bend lid, the first end of lid set up to 45 circular hollow tubes of tilt up, the second end of lid set up to 45 circular jacks of tilt up, the third end of lid set up to circular nut structure, just the third end of lid be used for the spiral shell to connect sampling tube.

Preferably, the round through hole at the first end of the box cover is provided with a cut which is parallel to the sampling tube, and the cut is used for sleeving the disposable breathable antiviral non-woven fabric elastic cover.

Preferably, the circular insertion hole is a hole with a quick insertion port, and a first conical hollow cup body which is wrapped by a waterproof film at the outer layer and molded by a permeable film at the inner layer is inserted into the hole and is made of a high-molecular water-absorbing material and a permeable film for absorbing and removing thin saliva and collecting thick sputum.

Preferably, a first cup plug with an open lower end is inserted into the conical hollow cup body, and a first film bag with a packaged reagent, a first round hollow tube and a first elastic pressing type puncture needle are placed in the first cup plug.

Preferably, the outer layer of wearable unit include three-dimensional shell, support, ear area and the outside air discharge fan of plastic materials preparation, the inlayer of wearable unit be the disposable non-woven fabrics gauze mask that has the hole, the gas vent of wearable unit be provided with outside air discharge fan, outside air discharge fan pipeline in set up and to have the disinfection unit that plasma disinfection illumination LED lamp was coated.

This a wearable testing arrangement for sputum collection realizes virus screening, its key feature is, wearable device include lid, kit, three-dimensional base, sample cell, phlegm eliminating unit and wearable unit, the lid cover establish the kit on, the kit cup joint the setting and be in three-dimensional base on, lid, three-dimensional base, sample cell and phlegm eliminating unit insert in proper order and establish wearable testing arrangement in.

Preferably, the box cover is a socket four-way box cover with a rectangular convex center, the first end of the box cover is provided with an oval hollow tube which is inclined upwards by 45 degrees, a square through hole is arranged at a preset position of the plane of the second end of the box cover, a cavity cylinder is arranged at the third end of the box cover, a preset position of the fourth end of the box cover is arranged to be a plane which is inclined upwards by 30 degrees, a first jack is preset on the plane, and the lower part of the box cover is arranged to be rectangular and used for being in socket joint with the kit.

Preferably, the first end of the box cover is arranged at the front view side of the socket four-way box cover, the second end of the box cover is arranged at the preset position of the front view side of the plane with the center in a rectangular convex shape, the third end of the box cover is arranged at the rear view side of the plane with the center in a rectangular convex shape, and the fourth end of the box cover is arranged at the bottom position of the rear view side of the plane with the center in a rectangular convex shape.

Preferably, the first end of the box cover is provided with an elliptical hollow pipe, and the elliptical hollow pipe is sleeved with a disposable breathable anti-virus non-woven fabric elastic cover.

Preferably, a second conical hollow cup body pressed by a high polymer water absorption material is inserted into the first insertion hole and used for blowing, absorbing and removing thin saliva and collecting thick sputum.

Preferably, a second cup plug with an open lower end is inserted into the second conical hollow cup body, and the second cup plug comprises a second film bag with a packaged reagent, a second circular hollow tube and a second elastic pressing type puncture needle.

Preferably, the sputum elimination unit comprises a sputum urging assembly and a sputum excretion assembly.

Particularly preferably, the sputum excretion component comprises a single-row independent pressing type shell group with a preset number, a single inclined flow channel and a square through hole which is obliquely arranged and connected with the box cover, wherein the single-row independent pressing type shell group comprises a pressing type shell and microporous screens with the number matched with that of the pressing type shells; the pressing type shell is arranged on the surface of the shell of the wearable unit, and pungent powder is placed in the pressing type shell; the inclined runner and the square through hole are arranged in the wearable unit; the microporous screen is used for filtering and screening the powder with the pungent smell.

Preferably, the sputum excretion assembly comprises a lower conical outlet pipe with a parallel outlet, an upper conical outlet pipe with a whistle vibrator and an air pressure regulator, and an upper disinfection unit and a lower disinfection unit of the disinfection illumination LED lamp coated with plasma, wherein the side surfaces of the upper conical outlet pipe and the lower conical outlet pipe are respectively provided with a reversing valve and a manual deflector rod of a movable air outlet pipeline for manual adjustment.

Preferably, a first preset number of independent vertical channels are arranged in the cavity cylinder at the third end of the box cover, a thin film bag containing a liquid reagent and a diversion trench are arranged in each independent vertical channel, and a rubber tube with a cap and a spring-pressing type pricker are arranged at the position of the top cover corresponding to each independent vertical channel.

Preferably, the inside of the reagent box is divided into a rectangular box body with a left space and a right space by a reagent box separating layer, and the rectangular box body is used for placing the second elastic pressing type pricking pins and the hollow cylinder.

Preferably, a square concave platform with a socket is arranged at the central position of the lower bottom of the reagent kit, the square concave platform and an elastic boss on the upper surface of the three-dimensional base are combined and assembled, so that the three-dimensional base and the reagent kit are combined and installed together, and a second preset number of quick sockets, buckles and threaded connectors for connecting the reagent kit are arranged at the edge position of the lower bottom of the reagent kit according to the length of the reagent kit.

Preferably, the sample unit comprises a sampling box and a sampling tube, wherein the sampling box is a rectangular box body, the upper end of the sampling box is provided with an opening, the inner side of the opening is provided with a notch, the outer edge of the opening is provided with a hollow transparent body which is matched with the buckle for installation, and a colloidal gold test strip which is vertically inserted is arranged in the rectangular box body; the sampling pipe be the circular pipe that has the external screw thread, the sampling pipe butt joint set up the bottom position of rectangle box body, and in the orificial corresponding position department of this sampling pipe the rectangle box body on, still be provided with this sampling pipe assorted sampling pipe tube cap.

Preferably, the solid base set up to rectangle or convex spatial structure, the central point at last top of solid base put and be provided with one and inlay and establish the elasticity boss of solid base's upper surface, each surface of elasticity boss all set up to little trapezium structure, just the elasticity boss in be provided with vibrations unit and weighing unit, solid base fix wearable testing arrangement in, solid base's inside be provided with triaxial gyroscope, piezoelectric sensor and circuit board module, the circuit board module in dispose voice prompt unit and time count unit, just triaxial gyroscope and piezoelectric sensor all with circuit board module looks electricity be connected.

By adopting the wearable device for sampling nucleic acid by utilizing sputum and the wearable test device for realizing virus screening by sputum collection, the utility model provides a noninvasive, efficient, economical and portable mode which is convenient for direct sputum collection at home, can be widely applied to the field of antigen-antibody detection of various respiratory viruses, and obviously improves the accuracy and detection speed of detection results according to clinical test data, and the screening proportion of asymptomatic or early-stage disease patients, thereby avoiding the risk of cross infection. Meanwhile, the device is suitable for operation and carrying, simple, convenient, efficient, economical and durable in production and manufacture, and is suitable for large-scale popularization and application.

Meanwhile, the noninvasive, easy-to-implement and efficient sampling mode adopted by the utility model can be used for detecting antibodies of new coronavirus (various pneumonia), and the detected data can be directly uploaded for a patient to take, so that the patient is prevented from contacting other infected patients, and the risk of infection of medical staff is reduced. Billions of people in China, if two billions of people are using the quick detection device, the people can collect the data, the health condition of the whole generation of China or the next generation of China can be predicted, and even the change of various directions such as the health, diet and living habits of people can be influenced.

Drawings

Fig. 1 is a left side view of the wearable device for nucleic acid sampling using sputum according to the present invention.

Fig. 2 is a schematic rear view of the wearable device for nucleic acid sampling using sputum according to the present invention.

Fig. 3 is a schematic view of an assembly structure of a box cover and a sampling tube of the wearable device for sampling nucleic acid by using sputum according to the present invention.

FIG. 4 is a schematic diagram of an assembly structure of a hollow cylinder and a spring-loaded lancet of the wearable device for sampling nucleic acid using sputum according to the present invention.

Fig. 5 is a schematic structural diagram of the conical hollow cup body and the cup plug of the wearable device for sampling nucleic acid by using sputum according to the present invention.

Fig. 6 is a left side view structural diagram of the wearable test device for sputum collection and virus screening according to the present invention.

Fig. 7 is a schematic rear view of the wearable test device for sputum collection and virus screening according to the present invention.

FIG. 8-1 is a schematic structural diagram of the box cover for virus screening in sputum collection according to the present invention.

Fig. 8-2 is a schematic view of an inverted structure of the box cover for virus screening in sputum collection according to the present invention.

FIG. 9 is a schematic structural diagram of a sampling cassette and a lid of the sampling cassette for virus screening in sputum collection according to the present invention.

FIG. 10 is a schematic diagram of the internal assembly structure of the kit for screening viruses in sputum collection according to the present invention.

FIG. 11-1 is a schematic diagram of a first structure of the sputum-aspirating assembly for virus screening in sputum collection according to the present invention.

Fig. 11-2 is a second structural schematic diagram of the sputum-inducing assembly for virus screening in sputum collection according to the present invention.

Fig. 12 is a schematic structural diagram of a three-dimensional base for virus screening in sputum collection according to the present invention.

Reference numerals

1 wearable device

2 sampling tube

3 sampling pipe connecting nut

4 support of wearable device

5 kit

6 box cover

7 Square through hole

8 outward exhaust fan

Lower killing unit of 9

10 upper air outlet

11 whistle vibrator and air pressure regulator

12 upper killing unit

13-1 stimulating powder

13-2 push type shell

13-3 micropore type screen mesh

13-4 inclined runner

14 switching valve and manual driving lever

15 disposable air-permeable antiviral non-woven fabric elastic cover

16 round hollow tube

17 hollow cylinder

18-1 second compression type lancet

18-2 pressure spring

18-3 plastic cover

18-4 pressure spring backing plate

19 circular jack

20 first conical hollow cup

21 first cup plug

22 hollow cylinder

23-pressing elastic type puncture needle

24 pouch liquid reagent

25 kit separation layer

26 disposable air-permeable antiviral non-woven fabric elastic mask

27 ear band of wearable device

28 foot seat of wearable testing device

29 sampling box fastener

30 sampling box quick connector

31 square concave table

32 sampling box

33 reagent strip

34 sampling box cover

35 three-dimensional base

36 elastic boss

37 vibration unit

38 weighing cell

39 circuit board unit

40 three-axis gyroscope and piezoelectric sensor

Detailed Description

In order to more clearly describe the technical contents of the present invention, the following further description is given in conjunction with specific embodiments.

Before explaining embodiments in accordance with the present invention in detail, it should be noted that first and second like relational terms are used hereinafter only to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. The terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.

Referring to fig. 1 and 2, the wearable device 1 for sampling nucleic acid using sputum comprises a box cover, a sampling cup, a sampling tube 2 and a wearable unit, wherein the sampling cup is inserted into the box cover, the box cover is screwed onto the sampling tube, the wearable unit is sleeved on the wearable device 1, and the box cover, the sampling cup and the sampling tube are inserted into each other and then are all arranged in the wearable device.

Referring to fig. 3, as a preferred embodiment of the present invention, the box cover is a screw cap type three-way box cover, a first end of the box cover is a circular hollow tube inclined upward by 45 °, a second end of the box cover is a circular insertion hole inclined upward by 45 °, a third end of the box cover is a circular nut structure, and the third end of the box cover is used for screwing the sampling tube.

As a preferable embodiment of the utility model, a cut arranged in parallel with the sampling tube is arranged at the round through hole at the first end of the box cover, and the cut is used for sleeving the disposable air-permeable antiviral non-woven fabric elastic cover 15.

As the preferred embodiment of the utility model, the circular insertion hole is a hole with a quick insertion port, and a first conical hollow cup body 20 which is wrapped by a waterproof film at the outer layer and made by a high-molecular water-absorbing material and a water-permeable film through mould pressing is inserted into the hole and is used for absorbing and removing thin saliva and collecting thick sputum.

Referring to fig. 5, as a preferred embodiment of the present invention, a first cup plug 21 with an open lower end is inserted into the first conical hollow cup body 20, and a first film bag with a packaged reagent, a first circular hollow tube 16 and a first spring type puncture needle are placed in the first cup plug 21.

In a preferred embodiment of the present invention, the outer layer of the wearable unit comprises a three-dimensional housing made of a plastic material, a bracket, an ear band and an outward exhaust fan 8, the inner layer of the wearable unit is a disposable non-woven mask with holes, the exhaust port of the wearable unit is provided with the outward exhaust fan, and a sterilizing unit coated with a plasma sterilizing and illuminating LED lamp is arranged in the pipeline of the outward exhaust fan 8.

In an embodiment of the present invention, the outward exhaust fan 8 adopted by the wearable device for nucleic acid sampling by sputum of the present invention is to form a negative pressure region inside the screw cap type three-way box cover, so as to reduce adverse factors that the aperture of the air outlet cut of the screw cap type three-way box cover 6 is too small and the exhalation resistance of the elastic cover 15 of the disposable air-permeable antiviral non-woven fabric is too large, thereby making the sampling cough and expectoration of the user smoother, and the sampling experience and the collecting effect better.

Please refer to fig. 6 and 7, the wearable testing device for virus screening in sputum collection includes a box cover, a kit, a three-dimensional base 35, a sample unit, an expectorant unit and a wearable unit, wherein the box cover is sleeved on the kit, the kit is sleeved on the three-dimensional base 35, and the box cover, the three-dimensional base 35, the sample unit and the expectorant unit are sequentially inserted into the wearable testing device.

Referring to fig. 8-1 and 8-2, as a preferred embodiment of the present invention, the box cover is a four-way box cover with a rectangular convex center, an elliptical hollow tube inclined upward by 45 ° is disposed at a first end of the box cover, a square through hole is disposed at a preset position on a plane of a second end of the box cover, a hollow cylinder 22 is disposed at a third end of the box cover, a plane inclined upward by 30 ° is disposed at a preset position on a fourth end of the box cover, a first insertion hole is preset on the plane, and a rectangular bottom of the box cover is configured to be sleeved with the reagent box.

As a preferred embodiment of the present invention, the first end of the box cover is disposed at the front view side of the four-way box cover, the second end of the box cover is disposed at a predetermined position at the front view side of the plane with the center being rectangular protrusion, the third end of the box cover is disposed at the rear view side of the plane with the center being rectangular protrusion, and the fourth end of the box cover is disposed at the bottom position at the rear view side of the plane with the center being rectangular protrusion.

In a preferred embodiment of the present invention, an elliptical hollow tube is provided at a first end of the box cover, and a disposable air-permeable antiviral non-woven fabric elastic cover 26 is sleeved on the elliptical hollow tube.

In a preferred embodiment of the present invention, a second conical hollow cup body pressed by a high molecular water-absorbing material is inserted into the first insertion hole, and is used for blowing, absorbing and removing thin saliva and collecting thick sputum.

As a preferred embodiment of the utility model, a second cup plug with an open lower end is inserted in the second conical hollow cup body, and the second cup plug comprises a second film bag for packaging reagents, a second round hollow tube and a second elastic pressing type puncture needle.

As a preferred embodiment of the utility model, the phlegm eliminating unit comprises a phlegm inducing component and a phlegm discharging component.

Referring to fig. 11-1 and 11-2, in an embodiment of the present invention, the sputum excretion inducing assembly includes a single row of four independent press-type housing sets, a single inclined flow channel 13-4, and a square through hole 7 connected to the box cover in an inclined manner, wherein the single row of independent press-type housing sets includes a press-type housing 13-2 and a micro-porous screen 13-3 in a number matching the four press-type housings; the pressing type shell is arranged on the surface of the shell of the wearable unit, and irritant powder 13-1 is placed in the pressing type shell, wherein the irritant powder 13-1 comprises but is not limited to one or a combination of any of chili powder, lemon powder, mustard powder and the like, and is used for generating a deep cough effect by pressing the inflow irritant powder into the throat of a detected person; the inclined runner 13-4 and the square through hole 7 are arranged in the wearable unit; the microporous screen is used for filtering and screening the powder with the pungent smell.

As a preferred embodiment of the present invention, the sputum discharging assembly includes a lower conical outlet pipe with parallel outlets, an upper conical outlet pipe with a whistle vibrator and an air pressure regulator 11, and an upper disinfection unit 12 and a lower disinfection unit 9 coated with plasma disinfection lighting LED lamps, and the side surfaces of the upper conical outlet pipe and the lower conical outlet pipe are respectively provided with a reversing valve and a manual deflector rod 14 of a movable outlet pipe for manual regulation.

As a preferred embodiment of the present invention, a first preset number of independent vertical channels are arranged in the cavity cylinder at the third end of the box cover, a thin film bag containing a liquid reagent and a diversion trench are arranged in each independent vertical channel, and a rubber tube with a cap and a spring type pricker 23 are arranged at a position of the top cover corresponding to each independent vertical channel.

Referring to fig. 10, as a preferred embodiment of the present invention, the inside of the reagent box is divided into two rectangular boxes with left and right independent spaces by a reagent box separating layer 25, for placing the second press spring type lancet and the hollow cylinder 22.

As a preferred embodiment of the present invention, a square concave platform 31 with a socket is arranged at the central position of the lower bottom of the reagent box, the square concave platform 31 and an elastic convex platform 36 on the upper surface of the three-dimensional base 35 are assembled, so that the three-dimensional base 35 and the reagent box are assembled together, and a second preset number of quick sockets 30, buckles 29 and threaded connectors for connecting the reagent box are arranged at the edge position of the lower bottom of the reagent box according to the length of the reagent box.

Referring to fig. 9, as a preferred embodiment of the present invention, the sample unit includes a sampling box and a sampling tube, wherein the sampling box is a rectangular box, the upper end of the sampling box is open, a notch is disposed inside the open, a hollow transparent body matched with the buckle 29 is disposed on the outer edge of the open, and a vertically inserted colloidal gold sample strip 33 is disposed in the rectangular box; the sampling pipe be the circular pipe that has the external screw thread, the sampling pipe butt joint set up the bottom position of rectangle box body, and in the orificial corresponding position department of this sampling pipe the rectangle box body on, still be provided with this sampling pipe assorted sampling pipe tube cap.

Referring to fig. 12, as a preferred embodiment of the present invention, the three-dimensional base 35 is configured to be a rectangular or circular arc three-dimensional structure, an elastic boss 36 embedded in the upper surface of the three-dimensional base 35 is disposed at a central position of an upper top portion of the three-dimensional base 35, each surface of the elastic boss 36 is configured to be a micro-trapezoidal structure, a vibration unit 37 and a weighing unit 38 are disposed in the elastic boss 36, the three-dimensional base 35 is fixed in the wearable testing device, a three-axis gyroscope, a piezoelectric sensor 40 and a circuit board module are disposed in the three-dimensional base 35, a voice prompt unit and a time counting unit are disposed in the circuit board module, and the three-axis gyroscope and the piezoelectric sensor 40 are electrically connected to the circuit board module.

In one embodiment of the present invention, the reagent strip used in the test kit for screening viruses of the present invention is specifically:

1. COVID-19 antigen detection reagent strip (colloidal gold method)

2. Influenza A/B virus antigen detection reagent strip (colloidal gold method)

The specific use mode is as follows:

the sampling kit comprises a pvc bottom plate, a sample pad, a sputum filtering pad, a combination pad, a nitrocellulose membrane and absorbent paper, wherein the sample pad, the blood filtering pad, the combination pad, the nitrocellulose membrane and the absorbent paper are sequentially and mutually staggered and lapped and then are adhered to the pvc bottom plate, and the sampling kit is obtained after insertion.

In a specific embodiment of the present invention, the test kit for virus screening in sputum collection of the present invention employs liquid reagents specifically including: the reagent 1 adopts a new coronavirus transport medium (VTM); the reagent 2 adopts inactivated virus transport medium (VTM-N); the

reagents

3, 4, 5, 6 and 7 are virus lysates.

In one embodiment of the present invention, in the sampling box of the test box for sputum collection to realize virus screening of the present invention, the colloidal gold reagent strip used is as follows:

3. COVID-19 antigen detection kit (colloidal gold method)

4. Novel influenza A H1N1 virus (colloidal gold method)

5. Mycoplasma pneumoniae antigen detection kit (colloidal gold method)

6. Influenza A/B virus antigen detection kit (colloidal gold method)

7. Respiratory syncytial virus antigen detection kit (colloidal gold method)

In a specific embodiment of the utility model, the sampling tube adopted by the test kit for screening viruses in sputum collection is a disposable sample conveying tube, and the sampling tube adopts an inlet polypropylene tube body and a polyethylene cover, and the tube body is 87mm high, so that the collected samples can be safely and effectively conveyed.

In a specific embodiment of the utility model, the test kit for virus screening in sputum collection of the utility model collects deep cough sputum in a disposable sterile screw cap sampling kit, and then adopts a colloidal gold method for marking, so that the test kit has the advantages of convenient operation, direct visual interpretation, high detection speed (10-15 minutes), high specificity, easy popularization and the like.

In a specific embodiment of the utility model, the double-antigen sandwich detection total antibody is adopted, so that the method not only has the advantages of early diagnosis of the novel coronavirus through IgM antibody detection, but also has the characteristics of detecting the prior infection (including a patient with decreased IgM in the recovery phase) of the IgG antibody, can better prevent omission, shorten the diagnosis window period, has higher specificity and sensitivity, saves the operation time and cost, is convenient and quick, reduces the cross contamination and other advantages, and has important value in novel coronavirus detection!

Referring to fig. 1, as a first embodiment of the utility model, by replacing the reagent, the device can be further extended to the subdivided fields of infectious disease detection (such as respiratory tract infection, aids, viral hepatitis, etc.), chronic disease management, tumor diagnosis and treatment, etc., and promote more detection items to realize rapidness and convenience.

In a specific embodiment of the utility model, by replacing the reagent, the fields of hepatitis B antibody, syphilis antibody [1], HIV antibody [2], hepatitis C antibody [3] and the like can be detected successfully, and the detection of the AIDS antibody is realized from an indirect method to a fourth generation of detection by a double-antigen sandwich method.

In a specific embodiment of the utility model, the VTM-N preservation solution can be used for quickly inactivating viruses, but the complete nucleic acid fragment can be preserved at room temperature for more than 1 month, and the sensitivity of subsequent nucleic acid detection can still be ensured. Although this sample cannot be used for culturing and isolating viruses, it can ensure safety in transporting the sample.

In one embodiment of the utility model, the sample provided by the preservation solution is basically live virus, so that the originality of the sample can be maintained to the maximum extent, and the sample can be subsequently used for not only nucleic acid extraction and detection of the virus, but also culture and separation of the virus. For detection, it should be noted that the nucleic acid must be inactivated and then extracted and purified.

Referring to fig. 6, as a second embodiment of the present invention, an input unit is used as a mouthpiece, a screw plug pressure regulating manual control check valve and a vibrating ball sputum aspirator, when the input unit is connected with the vibrating ball sputum aspirator, the input unit can vibrate the airway of a user to generate severe cough to loosen secretions in the airway by the principle of acting force and reaction force, so that thick sputum adhered to the airway is loosened and easily discharged (having the same sputum discharging function as the vibrating sputum aspirator), the loosened secretions are pushed into the upper large airway from bottom to top, the lung environment is improved, the secretion is favorably coughed, the air retention is reduced, and the respiratory function of the lung is improved. When the user feels that the sputum can be spitted, the plug screw pressure regulating manual control one-way valve is immediately adjusted to be in a straight-through state, so that the discharging of the breath and the air resistance in the screening box are facilitated when the user coughs and spits.

Referring to fig. 11, in a second embodiment of the utility model, the following powders are inhaled:

and (3) pepper powder: has the inherent spicy flavor of the pepper, stimulates the cough by inhalation, and stimulates the nose and sneeze by smelling;

mustard powder: has very spicy feeling and excellent degerming effect, and can stimulate cough when being inhaled;

radish seed powder: when the powder is used, it can ascend more than descend, and induce vomiting of phlegm and saliva.

Mustard seed powder: has pungent and pungent taste and irritation effect, and can be used as irritant phlegm eliminating medicine when inhaled in trace amount; can be used for treating phlegm retention in chest and hypochondrium, thick and viscous phlegm, phlegm dampness stagnation, rheumatism, salivation, lump formation, phlegm qi dyspnea, cough,

the technical scheme adopts polyethylene-propylene polymer (Polyallemer) plastic and certain specially processed Polypropylene (Polypropylene) plastic to manufacture the sampling container, and the sampling container is more suitable for storage and subsequent use of samples.

The operation flow of the wearable device for nucleic acid sampling by using sputum and the wearable test device for virus screening by sputum collection in the actual application process is shown in the following table 1:

TABLE 1

The wearable device (sputum, saliva and breath) adopting the sputum to screen the viruses has the following effects as shown in the following table 2:

TABLE 2

In the description herein, references to the description of terms "an embodiment," "some embodiments," "an example," "a specific example," or "an embodiment," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the utility model. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art within the scope of the present invention.

In this specification, the utility model has been described with reference to specific embodiments thereof. It will, however, be evident that various modifications and changes may be made thereto without departing from the broader spirit and scope of the utility model. The specification and drawings are, accordingly, to be regarded in an illustrative rather than a restrictive sense.

Claims

1. The utility model provides an utilize sputum to carry out wearable device of nucleic acid sampling, a serial communication port, wearable device include lid, sampling cup, sampling tube and wearable unit, wherein, sampling cup peg graft and set up the lid on, the lid connect the setting soon to be in the sampling tube on, wearable unit cup joint the setting and be in wearable device on, just lid, sampling cup, sampling tube between peg graft the installation back each other, all set up wearable device in.

2. The wearable device for nucleic acid sampling using sputum according to claim 1, wherein the lid is a screw cap type three-way lid, the first end of the lid is configured as a circular hollow tube tilted up by 45 °, the second end of the lid is configured as a circular insertion hole tilted up by 45 °, the third end of the lid is configured as a circular nut structure, and the third end of the lid is configured to screw the sampling tube.

3. The wearable device for nucleic acid sampling by using sputum according to claim 2, wherein the round through hole at the first end of the box cover is provided with a cut parallel to the sampling tube, and the cut is used for sleeving the disposable air-permeable antiviral non-woven fabric elastic cover.

4. The wearable device for nucleic acid sampling by using sputum according to claim 2, wherein the circular insertion hole is a hole with a quick-insertion port, and a first conical hollow cup body which is wrapped by a waterproof film as an outer layer and molded by a water-permeable film as an inner layer is made of a high-molecular water-absorbing material is inserted into the hole and is used for absorbing and removing thin saliva and collecting thick sputum.

5. The wearable device for sampling nucleic acid by using sputum according to claim 4, wherein a first cup plug with an open lower end is inserted into the conical hollow cup, and a first film bag with a bagged liquid reagent, a first circular hollow tube and a first press-and-spring type puncture needle are placed in the first cup plug.

6. The wearable device for sampling nucleic acid by using sputum according to claim 1, wherein an outer layer of the wearable unit comprises a three-dimensional shell made of a plastic material, a support, an ear band and an outward exhaust fan, an inner layer of the wearable unit is a disposable non-woven mask with holes, an exhaust port of the wearable unit is provided with an outward exhaust fan, and a disinfection unit coated with a plasma disinfection illumination LED lamp is arranged in an outward exhaust fan pipeline.

7. The utility model provides a wearable testing arrangement for sputum collection realizes virus screening, a serial communication port, wearable device include lid, kit, three-dimensional base, sample cell, phlegm eliminating unit and wearable unit, the lid cover establish the kit on, the kit cup joint the setting and be in three-dimensional base on, lid, three-dimensional base, sample cell and phlegm eliminating unit insert in proper order and establish wearable testing arrangement in.

8. The wearable test device for sputum collection and virus screening according to claim 7, wherein the box cover is a four-way box cover with a rectangular convex center, the first end of the box cover is provided with an elliptical hollow tube inclined upwards by 45 degrees, a square through hole is arranged at a preset position on the plane of the second end of the box cover, the third end of the box cover is provided with a hollow cylinder, the preset position on the fourth end of the box cover is a plane inclined upwards by 30 degrees, a first jack is preset on the plane, and the lower part of the box cover is rectangular for sleeving the kit.

9. The wearable test device for sputum collection and virus screening according to claim 8, wherein the first end of the lid is disposed at the front view side of the four-way socket lid, the second end of the lid is disposed at a predetermined position at the front view side of the plane with the rectangular protrusion at the center, the third end of the lid is disposed at the rear view side of the plane with the rectangular protrusion at the center, and the fourth end of the lid is disposed at the bottom position at the rear view side of the plane with the rectangular protrusion at the center.

10. The wearable test device for sputum collection and virus screening according to claim 9, wherein the first end of the box cover is provided with an elliptical hollow tube, and the elliptical hollow tube is sleeved with a disposable breathable anti-virus non-woven fabric elastic mask.

11. The wearable test device for sputum collection and virus screening according to claim 10, wherein a second conical hollow cup body pressed by a high polymer water-absorbing material is inserted into the first insertion hole for blowing, absorbing and removing thin saliva and collecting thick sputum.

12. The wearable test device for sputum collection and virus screening according to claim 11, wherein a second cup plug with an open lower end is inserted into the second conical hollow cup, and the second cup plug comprises a second thin film bag with a bagged liquid reagent, a second circular hollow tube and a second elastic pressing type puncture needle.

13. The wearable test device for sputum collection and virus screening according to claim 7, wherein the sputum elimination unit comprises a sputum urge component and a sputum excretion component.

14. The wearable test device for sputum collection and virus screening according to claim 13, wherein the sputum collection assembly comprises a single row of independent push type housing groups with a preset number, a single inclined flow channel and a square through hole obliquely arranged and connected with the box cover, wherein the single row of independent push type housing groups specifically comprise push type housings and microporous screens with the number matched with that of the push type housings; the pressing type shell is arranged on the surface of the shell of the wearable unit, irritant powder is placed in the pressing type shell, and the inclined flow channel and the square through hole are arranged in the wearable unit; the microporous screen is used for filtering and screening out the irritant powder.

15. The wearable testing device for sputum collection and virus screening according to claim 14, wherein the sputum discharging assembly comprises a lower conical outlet tube with parallel air outlets, an upper conical outlet tube with a whistle vibrator and a gas pressure regulator, and an upper disinfection unit and a lower disinfection unit of an LED lamp coated with plasma for disinfection and illumination, and the side surfaces of the upper conical outlet tube and the lower conical outlet tube are respectively provided with a reversing valve and a manual deflector rod of a movable air outlet pipeline for manual adjustment.

16. The wearable test device for sputum collection and virus screening according to claim 8, wherein a first preset number of independent vertical channels are provided in the hollow cylinder at the third end of the box cover, each of the independent vertical channels is provided with a thin film bag containing a liquid reagent and a diversion trench, and a rubber tube with a cap and a spring type puncture needle are provided at a position of the top cover corresponding to each of the independent vertical channels.

17. The wearable test device for sputum collection and virus screening according to claim 12, wherein the inside of the kit is divided into a rectangular box body with two independent spaces at left and right by a kit separating layer, and the rectangular box body is used for placing the second pressing and ejecting type puncture needle and the hollow cylinder.

18. The wearable test device for sputum collection and virus screening according to claim 17, wherein a square concave platform with a plug port is arranged at a central position of a lower bottom of the kit, and the square concave platform and an elastic boss on an upper surface of the three-dimensional base are assembled to make the three-dimensional base and the kit assembled together, and a second preset number of quick plug ports, buckles and threaded connectors for connecting the kit are arranged at an edge position of the lower bottom of the kit according to the length of the kit.

19. The wearable test device for sputum collection and virus screening according to claim 18, wherein the sample unit comprises a sampling box and a sampling tube, wherein the sampling box is a rectangular box body, the upper end of the sampling box is provided with an opening, the inner side of the opening is provided with a notch, the outer side edge of the opening is provided with a hollow transparent body matched with the buckle for installation, and the rectangular box body is internally provided with a vertically inserted colloidal gold test strip; the sampling pipe be the circular pipe that has the external screw thread, the sampling pipe butt joint set up the bottom position of rectangle box body, and in the orificial corresponding position department of this sampling pipe the rectangle box body on, still be provided with this sampling pipe assorted sampling pipe tube cap.

20. The wearable test device for sputum collection for viral screening of claim 19, it is characterized in that the three-dimensional base is of a rectangular or circular arc three-dimensional structure, an elastic boss embedded on the upper surface of the three-dimensional base is arranged at the central position of the upper top of the three-dimensional base, each surface of the elastic boss is of a micro-trapezoidal structure, and a vibration unit and a weighing unit are arranged in the elastic boss, the three-dimensional base is fixed in the wearable testing device, the three-dimensional base is internally provided with a three-axis gyroscope, a piezoelectric sensor and a circuit board module, the circuit board module is internally provided with a voice prompt unit and a time counting unit, and the three-axis gyroscope and the piezoelectric sensor are electrically connected with the circuit board module.