CN113456914A - Flat-plate rolling type dialyzer - Google Patents
Flat-plate rolling type dialyzer Download PDFInfo
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- CN113456914A CN113456914A CN202110765901.XA CN202110765901A CN113456914A CN 113456914 A CN113456914 A CN 113456914A CN 202110765901 A CN202110765901 A CN 202110765901A CN 113456914 A CN113456914 A CN 113456914A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1623—Disposition or location of membranes relative to fluids
- A61M1/1627—Dialyser of the inside perfusion type, i.e. blood flow inside hollow membrane fibres or tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1631—Constructional aspects thereof having non-tubular membranes, e.g. sheets
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Separation Using Semi-Permeable Membranes (AREA)
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Abstract
The invention discloses a flat-plate rolling type dialyzer which comprises a dialysis installation shell, a flat-plate composite membrane structure and a central tube; two ends of the central tube extend out of the dialysis mounting shell, and the central tube is provided with a liquid inlet through hole and a liquid outlet through hole; the inner cavity of the central tube is provided with a blocking part; the flat composite membrane structure comprises two layers of membranes, two flow spaces are arranged between the two layers of membranes, and both the two spaces are provided with flow openings; the flat composite membrane structure is wound on the outer side of the central tube, and the flow openings of the two flow spaces are respectively communicated with the liquid inlet through hole and the liquid outlet through hole; the both ends of dialysis installation shell are equipped with inlet and liquid outlet respectively, communicate each other between inlet, dull and stereotyped composite membrane structure's the membrane book clearance and the liquid outlet. The dialyzer not only has the advantages of easy cleaning, low water consumption, high yield, simple manufacturing process and the like, but also integrates the filtering and dialysis functions into a whole, filters dialysate before dialysis and avoids polluting blood.
Description
Technical Field
The invention relates to a dialyzer, in particular to a flat plate rolling dialyzer.
Background
Hemodialysis is a treatment project for maintaining the life of a patient suffering from urea diseases, and a dialyzer is a core medical consumable for dialysis treatment. The products of dialyzers in the prior art and clinical treatment are all hollow fiber membrane dialyzers of polysulfone family [ polysulfone Polysulfonfon (PS) and polyether sulfone Polysulfonfon (PES) ], and the structure is that a hollow fiber membrane is arranged in a shell of the dialyzer, and two ends of the dialyzer are fixed by resin glue. The casing of the dialyzer is provided with two end covers, and blood enters from one end cover and flows out from the other end cover after passing through the hollow fibers. One end side of the shell is provided with a dialysate inlet, and the other end side is provided with a dialysate outlet. When the dialyzer is used for clinical treatment, blood of a patient is led out from a artery through a dialysis pipeline and a blood pump, enters a hollow fiber membrane of the dialyzer, and returns to the body of the patient through an outlet of the dialyzer. Further, in the above-mentioned dialyzer, the hollow fiber dialysis membrane is a core component, and the dialysis of blood mainly relies on the hollow fiber dialysis membrane, and various methods for preparing hollow fibers have been proposed in the prior art, such as a polysulfone hollow fiber semipermeable membrane and its components disclosed in chinese patent application publication No. CN1158273A, and a modified polyethersulfone hollow fiber membrane and its manufacturing method disclosed in chinese patent application publication No. CN 1680010A.
The prior hollow fiber dialyzer has the following defects:
1. the hollow fiber membrane has a small pore diameter ratio, the pore diameter is generally 0.2mm, the outer diameter is about 0.28-0.3mm, blood passes through the membrane under a high pressure state, membrane rupture is easy to occur, good anticoagulation effect is required for the blood, the hollow fiber has good biocompatibility, otherwise, the blood can be blocked in small membrane pores to form thrombus, and the curative effect is influenced. Further, the inner pores of the hollow fiber membranes have projections "burrs", and when blood flows at a high speed and collides with the "burrs", blood cells (red blood cells, white blood cells, platelets) in the blood are easily damaged, and the blood is easily destroyed.
2. The membrane exchange area of the hollow fiber dialyzer in the prior art is usually between 1.4 and 2.0 square meters. The exchange area of the hollow fiber membrane with the minimum size of 1.4 is calculated, and the number of the hollow fibers is up to about 8000; up to 12,000 hollow fibers may be present in an area of 2.0. The bundle of hollow fiber membranes, which is formed by bundling such a plurality of fine hollow fibers, is placed in a housing having a diameter of about 50 mm, and the hollow fibers are almost tightly adhered together. Especially, after the hollow fibers are wetted, the hollow fibers are seriously adhered together, so that a large number of membrane holes are blocked, the contact between blood in the hollow fibers and dialysate is greatly hindered, especially, the fibers at the central part of the fiber bundle can hardly contact the dialysate, the clearance of a dialyzer is not matched with the corresponding membrane exchange area, and the treatment effect is seriously influenced.
3. In the manufacturing process, the inner hole of the hollow fiber is 0.2mm, the inner hole is generated by injecting organic solvent core liquid, the core liquid is wrapped in the center of the hollow fiber by membrane-forming liquid, after the hollow fiber is sprayed into a solidified water bath for forming, the organic solvent in the inner hole of the hollow fiber membrane is difficult to be completely cleaned and discharged in the post-cleaning and drying processes, and the inner hole of the dried hollow fiber contains a large amount of clean organic solvent which is not cleaned after being dried. When the organic solvent is used for treatment, if the organic solvent is not washed clean, the organic solvent can directly contact with blood and enter a human body, and the organic solvent has a great harm effect on the liver, eyeballs, skin and the like of the human body after being used for a long time.
4. The production equipment for producing the hollow fiber in the prior art has huge investment and needs dozens of sections of washing tanks for cleaning and dozens of sections of hot air for drying. The water consumption is large, the energy consumption is high, the environmental pollution is easy to happen, the rejection rate of finished products is high, the production cost is high, and the price of the finished products is high directly.
Disclosure of Invention
The invention aims to overcome the existing problems and provides a flat plate rolling type dialyzer which not only has the advantages of good water wettability, easy cleaning, small water consumption, high yield, simple manufacturing process and the like, but also integrates the filtering and dialysis functions into a whole, filters dialysate before dialysis and avoids impurities from entering blood along with the dialysate to pollute the blood.
The purpose of the invention is realized by the following technical scheme:
a flat plate rolling type dialyzer comprises a dialysis installation shell, a flat plate composite membrane structure and a central tube for conveying dialysate;
the central tube is arranged in the dialysis installation shell, and two ends of the central tube extend out of the dialysis installation shell and are communicated with a pipeline for providing dialysate; the central tube is provided with a liquid inlet through hole and a liquid outlet through hole which are distributed along the axial direction; the inner cavity of the central tube is provided with a blocking part which divides the inner cavity of the central tube into two parts which are respectively communicated with the liquid inlet through hole and the liquid outlet through hole;
the flat composite membrane structure comprises two layers of membranes which are arranged in an overlapped mode and fixedly connected, the space between the two layers of membranes is set into two flowing spaces, and the two flowing spaces are provided with flowing openings; at one end provided with the flow opening, the membrane edges of the two layers of membranes are arranged in a staggered manner to form a liquid inlet and a liquid outlet of two flow spaces;
the flat composite membrane structure is wound on the outer side of the central tube, and the flow openings of the two flow spaces are respectively communicated with the liquid inlet through hole and the liquid outlet through hole of the central tube;
the both ends of dialysis installation shell are equipped with inlet and liquid outlet respectively, communicate each other between inlet, dull and stereotyped composite membrane structure's the membrane book clearance and the liquid outlet.
The working principle of the flat plate rolling type dialyzer is as follows:
during operation, the blood to be dialyzed is introduced into the dialysis mounting shell through the liquid inlet, and the blood to be dialyzed flows downwards along the film roll gap (the film roll gap is the outer side gap of the rolled membrane) of the flat composite membrane structure. Meanwhile, in letting in the center tube with the dislysate, the dislysate flows down along the axial, under the blocking of barrier portion, the dislysate flows out from one of them through-hole, in the flow space that flow opening entering correspondence with this through-hole intercommunication, then along the flow space of helical shape forward flow, permeate outside the membrane simultaneously to with the outer blood fusion of membrane, the mixed liquid after the fusion continues the membrane book clearance axial flow along. When the mixed liquid flows to a separation position, namely the fused mixed liquid flows from the outer side of one of the flow spaces to the outer side of the other flow space, under the action of negative pressure, the dialysate carries waste matters (urea nitrogen, creatinine, phosphorus, macromolecular substances B2-microglobulin and the like) in blood to permeate into the other flow space from the gap of the membrane coil, then flows back into the central tube from the flow opening of the other flow space through the corresponding through hole, and then flows to a dialysis circuit from the central tube for further treatment; and the dialyzed blood continues to flow downwards along the gap of the film roll and finally flows back to the human body from the liquid outlet of the dialysis installation shell.
In a preferred embodiment of the invention, a flow channel is provided between the two flow spaces, which channel communicates with each other.
Preferably, the flow channel is arranged at an end remote from the flow opening.
Through above-mentioned structure, when flowing along the flowing space of spiral shape forward, one of them part dislysate can permeate towards the membrane outward, fuses with blood, and remaining another part dislysate can get into in another flowing space from flow channel, then gets back to the center tube through the feed liquor through-hole, flows to the dialysis return circuit from the center tube at last. Like this, through getting through two flow spaces, get through the direct passageway that flows forward in other words, when the dislysate carries out the infiltration, can accelerate the flow of dislysate for the transport of dislysate is more smooth, is favorable to improving dialysis efficiency.
According to a preferable scheme of the invention, a plurality of liquid inlet through holes and a plurality of liquid outlet through holes are formed, and the liquid inlet through holes and the liquid outlet through holes are uniformly distributed along the circumferential direction respectively;
the plurality of flat composite membrane structures are wound outside the central tube in a mode of overlapping along the circumferential direction, and the flow openings of the plurality of flat composite membrane structures are respectively communicated with the corresponding liquid inlet through holes and the corresponding liquid outlet through holes. Through above-mentioned structure, after the dislysate got into the center tube, can get into the flow space of different flat compound membrane structures respectively from a plurality of through-holes of arranging along the circumferencial direction, carry out the dialysis operation simultaneously, can improve dialysis efficiency and obtain better dialysis effect.
In a preferred embodiment of the present invention, an intermediate layer located between two membranes is disposed in the flat composite membrane structure, and the intermediate layer is composed of an isolation net or a loose support.
In a preferred embodiment of the present invention, the membrane located at the bottom layer is a homogeneous membrane or an asymmetric semi-permeable membrane or a composite semi-permeable membrane with a support structure, and the membrane located at the top layer is an asymmetric semi-permeable membrane or a composite semi-permeable membrane with a porous support structure.
Preferably, the semi-permeable membranes are co-directional or counter-directional.
Preferably, the support structure of the composite semipermeable membrane forms a support in the direction of the flow of the liquid.
In a preferred aspect of the present invention, a size of the flow space corresponding to the liquid inlet through hole in the axial direction is larger than a size of the flow space corresponding to the liquid outlet through hole in the axial direction.
In a preferred embodiment of the present invention, the flow space is rectangular, wherein one side of the flow space is open to form the flow opening, and the remaining three sides are sealed.
In a preferred embodiment of the present invention, a sealing edge is shared between the two flow spaces, and during the forming process, three sides of the two flow spaces can be sealed to form a large pocket, and then the three flow spaces are separated into two independent flow spaces (dialysis bags) by separating the three flow spaces from each other at the middle position.
Compared with the prior art, the invention has the following beneficial effects:
1. the flat-plate rolling dialyzer adopts a flat-plate rolling structure, blood flows in the gaps of the rolled membrane rolls without entering a high-pressure state, and the flow channels (the gaps of the membrane rolls) have larger sizes, so that the phenomena of blood blockage and membrane rupture cannot easily occur, and the curative effect of thrombus can be improved.
2. Because the blood flows in the film roll gap of the film, the film exchange area is equivalent to the surface area of the whole film, so that the blockage can not be caused, and the blood can be in full contact with the dialysate to carry out the sufficient dialysis.
3. Before rolling and forming, the flat plate type dialysis membrane structure can be flattened, the inner surface and the outer surface of the membrane can be directly washed, the cleaning is easy, the organic solvent can be thoroughly cleaned, the organic solvent is prevented from contacting with blood to enter a human body and damaging the liver, eyeballs, skin and the like of the human body, the water consumption can be saved, and the production cost can be reduced.
4. Through setting up two flowing spaces, let in one of them flowing space with the dislysate earlier, when the dislysate is appeared from this flowing space, utilize the diaphragm to filter the dislysate in other words, can filter the impurity in the dislysate, prevent that impurity from polluting blood along with the dislysate gets into in the blood of treating the dialysis.
5. Through will filtering and the integration of dialysis function in same dull and stereotyped complex film structure, not only can filter the dislysate before the dialysis, can also reduce whole dialysis unit's occupation space, simplify manufacturing procedure, reduction in production cost.
6. Because the flat-plate dialysis membrane structure adopts a double-layer membrane rolling structure, a blood channel with extremely small aperture does not need to be manufactured, and the manufacturing difficulty and the production cost are reduced.
Drawings
Fig. 1 is a schematic perspective view of a flat-plate rolling dialyzer in the present invention.
Fig. 2 is a sectional view of a flat-plate take-up dialyzer in the present invention.
Fig. 3 is a schematic perspective explosion view of a flat-plate rolling dialyzer in the present invention.
FIG. 4 is a schematic view showing a first embodiment of the flat composite membrane structure and a structure of a center tube in the present invention, in which the flat dialysis membrane structure for producing a dialyzer is in an unfolded state.
Fig. 5 is a radial cross-sectional view of a flat-plate take-up dialyzer in the present invention.
FIG. 6 is a schematic structural view of a central tube and a second embodiment of the flat composite membrane structure of the present invention, in which the flat dialysis membrane structure for producing a dialyzer is in an unfolded state.
FIG. 7 is a schematic plan view of a third embodiment of a flat composite membrane structure according to the present invention.
FIG. 8 is a schematic plan view of a fourth embodiment of a flat composite membrane structure according to the present invention.
Detailed Description
In order to make those skilled in the art understand the technical solutions of the present invention well, the following description of the present invention is provided with reference to the embodiments and the accompanying drawings, but the embodiments of the present invention are not limited thereto.
Example 1
Referring to fig. 1-5, the flat-plate rolling dialyzer in the present embodiment includes a dialysis mounting shell 1, a flat-plate composite membrane structure 2, and a central tube 3 for conveying dialysate; the central tube 3 is arranged in the dialysis installation shell 1, and two ends of the central tube 3 extend out of the dialysis installation shell 1 and are communicated with a pipeline for providing dialysate; the central tube 3 is provided with a liquid outlet through hole 3-1 and a liquid inlet through hole 3-2, and the liquid outlet through hole 3-1 and the liquid inlet through hole 3-2 are distributed along the axial direction; the inner cavity of the central tube 3 is provided with a blocking part 3-3, and the blocking part 3-3 divides the inner cavity of the central tube 3 into two parts which are respectively communicated with the liquid outlet through hole 3-1 and the liquid inlet through hole 3-2.
An intermediate interlayer positioned between the two layers of membranes 2-1 is arranged in the flat composite membrane structure 2 and consists of an isolation net or a loose support.
Furthermore, the membrane 2-1 at the bottom layer is a homogeneous membrane or an asymmetric semi-permeable membrane or a composite semi-permeable membrane with a support structure, and the membrane 2-1 at the upper layer is an asymmetric semi-permeable membrane or a composite semi-permeable membrane with a loose support structure.
Further, the semi-permeable membranes are in the same direction or opposite directions; the support structure of the composite semipermeable membrane forms a support in the direction of the flow of the liquid.
Referring to fig. 1-5, the flat composite membrane structure 2 includes two layers of membranes 2-1 disposed in an overlapping manner and fixedly connected, a space between the two layers of membranes 2-1 is set as two independent flow spaces 2-1-1, and both the two flow spaces 2-1-1 are provided with flow openings; in each flow space 2-1-1, the other parts except the flow opening are closed structures; at one end provided with the flow opening, the membrane edges of the two layers of membrane sheets 2-1 are arranged in a staggered way to form a liquid inlet and a liquid outlet of the two flow spaces 2-1-1.
The flat composite membrane structure 2 is wound on the outer side of the central tube 3, and the flow openings of the two flow spaces 2-1-1 are respectively communicated with the liquid outlet through hole 3-1 and the liquid inlet through hole 3-2 of the central tube 3 (membrane edges are connected to the corresponding positions of the two groups of through holes of the central tube 3 in a sticking mode); wherein, the size of the flowing space 2-1-1 corresponding to the liquid inlet through hole 3-2 in the axial direction is larger than that of the flowing space 2-1-1 corresponding to the liquid outlet through hole 3-1 in the axial direction.
The two ends of the dialysis installation shell 1 are respectively provided with a liquid inlet 1-1 and a liquid outlet 1-2, and the liquid inlet 1-1, the film roll gap 5 of the flat composite film structure 2 and the liquid outlet 1-2 are communicated with each other.
Referring to fig. 1-3, four liquid outlet through holes 3-1 and four liquid inlet through holes 3-2 are respectively arranged, and the four liquid outlet through holes 3-1 and the four liquid inlet through holes 3-2 are respectively and uniformly distributed along the circumferential direction; the four flat composite membrane structures 2 are wound outside the central tube 3 in an overlapped mode along the circumferential direction, and the flow openings of the flat composite membrane structures 2 are respectively communicated with the corresponding liquid outlet through holes 3-1 and the corresponding liquid inlet through holes 3-2. Through the structure, after dialysate enters the central tube 3, the dialysate can enter the flowing spaces 2-1-1 of the different flat composite membrane structures 2 respectively from the through holes arranged along the circumferential direction, and the dialysis operation is carried out simultaneously, so that the dialysis efficiency can be improved and a better dialysis effect can be obtained. Of course, the liquid outlet through hole 3-1 and the liquid inlet through hole 3-2 can be arranged to be two, three, five or even more.
Referring to fig. 4, the flow space 2-1-1 is rectangular, wherein one side is open to form the flow opening and the remaining three sides are sealed.
The two flowing spaces 2-1-1 share a sealing edge, and in the forming process, three edges of the two flowing spaces can be sealed firstly to form a large pocket, and then the three flowing spaces are separated into two independent flowing spaces 2-1-1 (dialysis bags) by separating the three flowing spaces from the middle.
Referring to fig. 1-5, the working principle of the flat plate rolling dialyzer in this embodiment is:
when the dialysis device works, blood to be dialyzed is introduced into the dialysis installation shell 1 through the liquid inlet 1-1, and the blood to be dialyzed flows downwards along the film roll gap 5 of the flat composite film structure 2 (the film roll gap 5 is the outer side gap of the rolled membrane 2-1). Meanwhile, the dialysate is led into the central tube 3 and flows downwards along the axial direction, under the blocking of the blocking part 3-3, the dialysate flows out of the liquid outlet through hole 3-1 and enters the corresponding flowing space 2-1-1 through the flowing opening communicated with the liquid outlet through hole 3-1, then flows forwards along the spiral flowing space 2-1-1, and permeates outside the membrane, so that the dialysate is fused with the blood outside the membrane, and the fused mixed liquid continues to flow axially along the membrane roll gap 5. When the mixed liquid flows to the separation position, namely the fused mixed liquid flows from the outer side of one of the flow spaces 2-1-1 to the outer side of the other flow space 2-1-1, under the action of negative pressure, the dialyzate carrying waste matters (urea nitrogen, creatinine, phosphorus, macromolecular substances B2-microglobulin and the like) in the blood permeates into the other flow space 2-1-1 from the film roll gap 5, then flows back into the central tube 3 from the flow opening of the other flow space 2-1-1 through the liquid inlet through hole 3-2 and flows to the dialysis loop from the central tube 3 for further treatment; the dialyzed blood continues to flow downwards along the film roll gap 5 and finally flows back to the human body from the liquid outlet 1-2 of the dialysis installation shell 1.
Example 2
Referring to fig. 6, in contrast to embodiment 1, an intercommunicating flow channel 6 is provided between the two flow spaces 2-1-1, which flow channel 6 is arranged at the end remote from the flow opening. With the above structure, when the dialysate flows forward along the spiral flow space, a part of the dialysate permeates out of the membrane and is merged with blood, and the other part of the dialysate flows into the other flow space 2-1-1 from the flow channel 6, then returns to the central tube 3 through the liquid inlet through hole, and finally flows to the dialysis loop from the central tube 3. Therefore, by opening the two flowing spaces 2-1-1, which is equivalent to opening a direct forward flowing channel, the flow of the dialysate can be accelerated while the dialysate is permeated, so that the dialysate can be conveyed more smoothly, and the dialysis efficiency can be improved.
Example 3
Referring to fig. 7, the sealing edge in this embodiment includes a straight edge and a circular arc edge, unlike embodiment 1. Of course, other sealing structures are possible.
Example 4
Referring to fig. 8, unlike embodiment 1, the two flow spaces 2-1-1 in this embodiment have a gap with a certain distance therebetween, and do not share a sealing edge; and a flow channel 6 communicating with each other is arranged between the two flow spaces 2-1-1.
The present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents and are included in the scope of the present invention.
Claims (10)
1. A flat-plate rolling type dialyzer is characterized by comprising a dialysis mounting shell, a flat-plate composite membrane structure and a central tube for conveying dialysate;
the central tube is arranged in the dialysis installation shell, and two ends of the central tube extend out of the dialysis installation shell and are communicated with a pipeline for providing dialysate; the central tube is provided with a liquid inlet through hole and a liquid outlet through hole which are distributed along the axial direction; the inner cavity of the central tube is provided with a blocking part which divides the inner cavity of the central tube into two parts which are respectively communicated with the liquid inlet through hole and the liquid outlet through hole;
the flat composite membrane structure comprises two layers of membranes which are arranged in an overlapped mode and fixedly connected, the space between the two layers of membranes is set into two flowing spaces, and the two flowing spaces are provided with flowing openings; at one end provided with the flow opening, the membrane edges of the two layers of membranes are arranged in a staggered manner to form a liquid inlet and a liquid outlet of two flow spaces;
the flat composite membrane structure is wound on the outer side of the central tube, and the flow openings of the two flow spaces are respectively communicated with the liquid inlet through hole and the liquid outlet through hole of the central tube; the both ends of dialysis installation shell are equipped with inlet and liquid outlet respectively, communicate each other between inlet, dull and stereotyped composite membrane structure's the membrane book clearance and the liquid outlet.
2. Flat-plate take-up dialyzer according to claim 1, characterized in that intercommunicating flow channels are provided between the two flow spaces.
3. The flat-plate wrap-up dialyzer of claim 2, wherein the flow channels are disposed at an end distal to the flow openings.
4. The flat-plate rolling dialyzer according to claim 1, wherein a plurality of liquid inlet through holes and liquid outlet through holes are provided, and the plurality of liquid inlet through holes and the plurality of liquid outlet through holes are uniformly distributed along the circumferential direction; the plurality of flat composite membrane structures are wound outside the central tube in a mode of overlapping along the circumferential direction, and the flow openings of the plurality of flat composite membrane structures are respectively communicated with the corresponding liquid inlet through holes and the corresponding liquid outlet through holes.
5. The flat-plate rolling dialyzer according to claim 1, wherein an intermediate layer between two membranes is provided in the flat-plate composite membrane structure, and the intermediate layer is composed of an isolation net or a loose support.
6. The plat-wrap dialyzer according to claim 1 or 5, wherein the membrane located in the bottom layer is a homogeneous membrane or an asymmetric semipermeable membrane or a composite semipermeable membrane with a supporting structure, and the membrane located in the top layer is an asymmetric semipermeable membrane or a composite semipermeable membrane with a loose supporting structure.
7. The plate-wrap dialyzer of claim 6, wherein the semi-permeable membranes are co-directional or counter-directional.
8. The plate-wrap dialyzer of claim 6, wherein the support structure of the composite semipermeable membrane forms a support in the direction of liquid flow.
9. The flat-plate wrap-up dialyzer according to claim 1, characterized in that the flow space is rectangular, wherein one side opening constitutes the flow opening and the remaining three sides are sealed against each other.
10. The flat-plate wrap-up dialyzer of claim 9, wherein one sealing edge is shared between the two flow spaces.
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| CN202110765901.XA CN113456914B (en) | 2021-07-06 | 2021-07-06 | Flat plate winding type dialyzer |
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| CN202110765901.XA CN113456914B (en) | 2021-07-06 | 2021-07-06 | Flat plate winding type dialyzer |
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