CN113456671B - Friendly type durable antibacterial disinfection gel and preparation method thereof - Google Patents
Friendly type durable antibacterial disinfection gel and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/40—Peroxides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention provides a friendly type durable antibacterial disinfection gel and a preparation method thereof, and the method comprises the following steps: adding a precipitator and a hydrogen peroxide solution into a metal salt solution, washing and separating to obtain nano peroxide particles with surfaces rich in hydroxyl; dissolving a dispersing agent and a humectant in water to prepare a first solution, and adding nano peroxide particles with surfaces rich in hydroxyl into the first solution; uniformly suspending peroxide particles with surfaces rich in hydroxyl groups in the first solution after stirring and ultrasonic dispersion to obtain a nano peroxide particle suspension; dissolving the gel matrix in water to prepare a second solution, slowly adding the nano peroxide particle suspension into the second solution, and adding the gelling agent to obtain the antibacterial and disinfectant gel containing the nano peroxide particles. The invention aims to provide a slow-release antibacterial disinfecting gel which is low in cost, durable in antibacterial property, broad-spectrum in antibacterial activity and environment-friendly and a preparation method thereof.
Description
Technical Field
The invention belongs to the field of antibacterial disinfectants, and particularly relates to a friendly type durable antibacterial disinfecting gel and a preparation method thereof.
Background
Along with the development of social economy and the continuous improvement of living standard of people, people pay more and more attention to health, and disinfection products and antibacterial agent resistant products are rapidly developed. The antibacterial disinfecting gel has good biocompatibility, is easy to coat and absorb, and is widely applied without polluting clothes. The disinfection gel commonly used in the market at present is ethanol antibacterial disinfection gel. But has strong irritation, easy volatilization, short action time and irritation to human skin. The polymer quaternary ammonium salt has the characteristics of small irritation, environmental friendliness and the like, and becomes a hotspot of antibacterial and disinfection research.
In the prior art, CN 110859990A discloses a chitosan quaternary ammonium salt antibacterial gel, but the antibacterial performance of the antibacterial gel is mild, and a cross-linking agent needs to be introduced, which causes secondary pollution to the environment. The nano metal ions have wide space in the antibacterial field due to the advantages of wide antibacterial range, high efficiency, long duration and the like. CN107929319A discloses a graphene nano-silver lidocaine sustained-release antibacterial gel which has excellent antibacterial performance and long acting time. However, silver, a heavy metal, is harmful to the human body in long-term contact. In addition, the catalyst often contains unreacted reducing agent and anion (such as NO) in the preparation process 3 - Etc.) directly affect the properties of the nanosilver sol. Therefore, the development of an antibacterial gel with excellent antibacterial performance, mildness and long-lasting effect is of great significance.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a slow-release antibacterial disinfecting gel which is low in cost, durable in antibacterial property, broad-spectrum in antibacterial activity and environment-friendly and a preparation method thereof. In the invention, the nano peroxide particles with rich hydroxyl on the surface are prepared; then adding the nano peroxide particles with the surfaces rich in hydroxyl into the mixed solution of the dispersing agent and the humectant to form a suspension of the nano peroxide particles; and finally, mixing the suspension of the nano peroxide particles with a gel system to finally obtain the slow-release antibacterial disinfection gel. When in use, the solid nano peroxide particles in the antibacterial disinfection gel have stability, and can slowly release active oxygen species by reacting with water, thereby achieving the lasting antibacterial effect.
According to a first aspect of the present invention, there is provided a method for preparing a friendly, durable, antibacterial, disinfecting gel, comprising the steps of:
adding a precipitator into the metal salt solution, mixing and stirring for 15-45 min, adding a hydrogen peroxide solution, continuously stirring for 45-75 min to fully react, and washing and separating to obtain nano peroxide particles with surfaces rich in hydroxyl groups;
dissolving 0.05-2 parts by mass of a dispersing agent and 3-10 parts by mass of a humectant in water to prepare a first solution, and washing and separating 0.01-3 parts by mass of nano peroxide particles with rich hydroxyl groups on the surface and directly adding the nano peroxide particles into the first solution; uniformly suspending the peroxide particles with the surfaces rich in hydroxyl groups in the first solution after stirring and ultrasonic dispersion for 10-30min to obtain a nano peroxide particle suspension;
dissolving 0.3-1 parts of gel matrix in water to prepare a second solution, adding 0-10 parts of humectant and 0-40 parts of water to the nano peroxide particle suspension to prepare a mixed solution, slowly adding the mixed solution to the second solution, uniformly mixing, and adding 0-0.5 part of gel to obtain the antibacterial and disinfectant gel containing the nano peroxide particles.
Further, the nano-peroxide particles with rich hydroxyl groups on the surfaces are nano-metal peroxide particles, and the metal peroxide is at least one selected from magnesium peroxide, calcium peroxide and zinc peroxide.
Further, the method comprises, among others,
the dispersing agent is at least one selected from polyethylene glycol and polyvinylpyrrolidone, and is preferably polyethylene glycol;
the humectant is at least one selected from glycerol and propylene glycol, and is preferably glycerol;
the gel matrix is selected from at least one of sodium alginate and carbomer, preferably carbomer;
the gelling agent is at least one selected from triethanolamine, ethylenediamine, sodium hydroxide and potassium hydroxide, and is preferably triethanolamine.
Further, adding 0-10 parts of humectant and 0-40 parts of water into the nano peroxide particle suspension to prepare a mixed solution, and slowly adding the mixed solution into the second solution, further comprising:
adding 0-10 parts of humectant, 0-40 parts of water and a compound antibacterial agent into the nano peroxide particle suspension to prepare a mixed solution, and slowly adding the mixed solution into the second solution; alternatively, the first and second liquid crystal display panels may be,
and adding 0-10 parts of humectant and 0-40 parts of water into the nano peroxide particle suspension to prepare a mixed solution, slowly adding the mixed solution into the second solution, and then adding the compound antibacterial agent.
Further, the compound antibacterial agent is selected from at least one of hydrogen peroxide and ethanol;
wherein, when the compound antibacterial agent is hydrogen peroxide, the mass concentration of the hydrogen peroxide in the antibacterial and disinfectant gel is not more than 1%; when the compound antibacterial agent is ethanol, the mass concentration of the ethanol in the antibacterial and disinfectant gel is not more than 50%.
Further, the method comprises, among others,
the metal salt is selected from at least one of nitrate, chloride, sulfate and acetate of magnesium, calcium and zinc, preferably at least one of nitrate and chloride of magnesium, calcium and zinc;
the precipitant is selected from at least one of ammonia water, sodium hydroxide and potassium hydroxide, and preferably the ammonia water;
the molar ratio of the metal salt to the precipitant is 1: 2-1: 4, the molar ratio of the metal salt to the hydrogen peroxide is 1: 1-1: 10.
according to a second aspect of the invention, a friendly durable antibacterial disinfection gel is provided, which comprises the following components in parts by weight: 0.01-3 parts of dispersed nano peroxide particles, 0.05-2 parts of a dispersing agent, 3-10 parts of a humectant, 0.3-1 part of a gel matrix, 0-0.5 part of a gelling agent and water;
the nanometer peroxide particles with the surfaces rich in hydroxyl groups are nanometer metal peroxide particles, and the metal peroxide is at least one selected from magnesium peroxide, calcium peroxide and zinc peroxide.
Further, the friendly type durable antibacterial disinfection gel is prepared by the following method:
adding a precipitator into a metal salt solution, mixing and stirring for 15-45 min, adding a hydrogen peroxide solution, continuously mixing and stirring for 45-75 min to fully react, and washing and separating to obtain nano peroxide particles with surfaces rich in hydroxyl groups;
dissolving 0.05-2 parts by mass of a dispersing agent and 3-10 parts by mass of a humectant in water to prepare a first solution, and adding 0.01-3 parts by mass of the nano peroxide particles with the surfaces being rich in hydroxyl groups into the first solution; uniformly suspending the nanometer peroxide particles with the surfaces rich in hydroxyl groups in the first solution after stirring and ultrasonic dispersion for 10-30min to obtain a nanometer peroxide particle suspension;
dissolving 0.3-1 parts of gel matrix in water to prepare a second solution, adding 0-10 parts of humectant and 0-40 parts of water to the nano peroxide particle suspension to prepare a mixed solution, slowly adding the mixed solution to the second solution, uniformly mixing, and adding 0-0.5 part of gel to obtain the antibacterial and disinfectant gel containing the nano peroxide particles.
Further, the air conditioner is provided with a fan,
the dispersing agent is at least one selected from polyethylene glycol and polyvinylpyrrolidone, and is preferably polyethylene glycol;
the humectant is at least one selected from glycerol and propylene glycol, and is preferably glycerol;
the gel matrix is selected from at least one of sodium alginate and carbomer, preferably carbomer;
the gelling agent is at least one selected from triethanolamine, ethylenediamine, sodium hydroxide and potassium hydroxide, and is preferably triethanolamine.
Further, the composite antibacterial agent also comprises a composite antibacterial agent, wherein the composite antibacterial agent is selected from at least one of hydrogen peroxide and ethanol;
when the compound antibacterial agent is hydrogen peroxide, the mass concentration of the hydrogen peroxide in the antibacterial and disinfectant gel is not more than 1%; when the compound antibacterial agent is ethanol, the mass concentration of the ethanol in the antibacterial and disinfectant gel is not more than 50%.
Generally, compared with the prior art, the above technical solution conceived by the present invention has the following beneficial effects:
the invention provides a friendly type durable antibacterial disinfection gel and a preparation method thereof, the method uses nano peroxide particles with slow release and rich hydroxyl on the surface as antibacterial raw materials to prepare the antibacterial disinfection gel, and the method comprises the following steps: firstly, preparing nano peroxide particles with surfaces rich in hydroxyl; then adding the nano peroxide particles with the surfaces rich in hydroxyl into the mixed solution of the dispersing agent and the humectant to form a suspension of the nano peroxide particles; and finally, mixing the suspension of the nano peroxide particles with a gel system to finally obtain the slow-release antibacterial disinfection gel. The method can better reserve the hydroxyl groups on the surface of the nano peroxide particles and ensure the activity of the nano particles; meanwhile, when in use, the solid nano peroxide particles in the antibacterial and disinfectant gel have stability, and can slowly release active oxygen species by reacting with water, thereby achieving the lasting antibacterial effect. In addition, experiments prove that the antibacterial disinfectant gel has good antibacterial effect, long lasting action time, no toxicity or harm to human bodies, simple preparation process and low cost. In addition, after the composite antibacterial agent is mixed and compounded with the composite antibacterial agent, the performance of the product can be further stabilized by the nano peroxide particles, so that the addition amount of the composite antibacterial agent is greatly reduced, and the antibacterial and disinfection effects are also good.
Drawings
FIG. 1 is a schematic diagram showing the interparticle force of dispersed nano-peroxide in a friendly durable antimicrobial disinfecting gel, which is realized according to the present invention;
FIG. 2 is a XRD representation of the dispersed nano-sized magnesium peroxide particles in a friendly durable antimicrobial antiseptic gel, achieved in accordance with example 1 of the present invention;
fig. 3 is a SEM representation of the dispersed nano magnesium peroxide particles in a friendly durable antimicrobial antiseptic gel, achieved in accordance with example 1 of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and do not limit the invention. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
It will be understood by those skilled in the art that the foregoing is only a preferred embodiment of the present invention, and is not intended to limit the invention, and that any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the scope of the present invention.
It should be noted that the term "first \ second" referred to in the present invention is only used for distinguishing similar objects, and does not represent a specific ordering for the objects, and it should be understood that "first \ second" may be interchanged in a specific order or sequence, if allowed. It should be understood that "first \ second" distinct objects may be interchanged under appropriate circumstances such that embodiments of the invention described herein may be practiced in sequences other than those described or illustrated herein.
The invention relates to a preparation method of a friendly type durable antibacterial disinfection gel, which comprises the following steps:
step 1: preparation of nano peroxide particles with rich hydroxyl groups on surfaces
Adding a precipitator into the metal salt solution, mixing and stirring for 15-45 min, then adding a hydrogen peroxide solution, continuously stirring for 45-75 min to fully react, and washing and separating to obtain nano peroxide particles with surfaces rich in hydroxyl groups;
step 2: preparation of a suspension of nanoperoxide particles
Dissolving 0.05-2 parts by mass of a dispersing agent and 3-10 parts by mass of a humectant in water to prepare a first solution, and adding 0.01-3 parts by mass of the nano peroxide particles with the surfaces rich in hydroxyl groups into the first solution; uniformly suspending the peroxide particles with the surfaces rich in hydroxyl groups in the first solution after stirring and ultrasonic dispersion for 10-30min to obtain a nano peroxide particle suspension;
and step 3: preparation of antimicrobial disinfecting gels comprising nanoperoxide particles
According to the mass parts, 0.3-1 part of gel matrix is dissolved in water to prepare a second solution, 0-10 parts of humectant and 0-40 parts of water are added into the nano peroxide particle suspension to prepare a mixed solution, the mixed solution is slowly added into the second solution, and 0-0.5 part of gel is added after uniform mixing, so that the friendly durable antibacterial disinfection gel is obtained.
In the step 1, dissolving a metal source in water to prepare a metal salt solution, adding a precipitator into the metal salt solution, mixing and stirring for 15-45 min, then adding a hydrogen peroxide solution, and continuously stirring for 45-75 min to fully react to obtain nano peroxide particles with surfaces rich in hydroxyl groups;
specifically, the metal salt is selected from at least one of nitrates, chlorides, sulfates, acetates of magnesium, calcium, zinc, but is not limited thereto, and is not limited to the specific raw materials used in the examples; preferably at least one of nitrate and chloride of magnesium, calcium and zinc;
specifically, the precipitant can be at least one of ammonia water (with a mass fraction of 25% to 28%), sodium hydroxide or potassium hydroxide, but is not limited thereto, and is further not limited to the specific raw materials used in the examples; preferably ammonia water (mass fraction is 25-28%).
Specifically, the mass concentration of hydrogen peroxide in the mixed solution is 8-15%
Specifically, the molar ratio of the metal salt to the precipitant is 1: 2-1: 4, the molar ratio of the metal salt to the hydrogen peroxide is 1: 1-1: 10.
specifically, the stirring speed in the whole reaction process is 100 r/min-280 r/min, the reaction time is more than 1 hour, and the reaction pH range is controlled to be 8-10.
Specifically, the nano-peroxide particles with rich hydroxyl groups on the surface are nano-metal peroxide particles, and the metal peroxide is at least one selected from magnesium peroxide, calcium peroxide and zinc peroxide, but not limited to the nano-metal peroxide particles, and is not limited to the specific raw materials used in the examples.
More specifically, as shown in fig. 1, the black particles are nanoperoxide particles, and the surface of the nanoperoxide particles without drying is rich in OH - On the one hand, agglomeration of the nanoparticles can be prevented; on the other hand, the uniform dispersion in the water phase is also facilitated. Surface OH of commercial (nano) peroxide powder due to drying treatment - Greatly reduces and even generates particle agglomeration, is not beneficial to uniform dispersion in solution or gel, can cause serious aggregation and precipitation, and further influences the performance.
As shown in FIGS. 2 and 3, which are respectively a characterization diagram of XRD and SEM of the nano magnesium peroxide particles prepared by the specific embodiment of step 1, it can be seen from FIG. 2 that relatively pure magnesium peroxide particles can be prepared by step 1, and the XRD peaks thereof correspond to the magnesium peroxide card of JCPDS 01-076-1363. As can be seen from FIG. 3, the nano magnesium peroxide particles prepared in step 1 are spherical-like nanoparticles with regular morphology and uniform particle size, and the particle size is about 30-70 nm; as a solid material, the peroxide is more stable than other liquid antibacterial components, such as ethanol having a recovery property or hydrogen peroxide which is easily decomposed, and thus the solid nano magnesium peroxide particles can sufficiently contact with water after contacting with water, thereby effectively and slowly releasing active oxygen species.
More specifically, the solid-state nano peroxide particles can be slowly decomposed to release active oxygen species after meeting water, so that the effect of continuous and long-term sterilization and disinfection is achieved, and the active oxygen species are substances with strong activity generated in the electron transfer process of oxygen, have strong oxidizability, and can effectively kill bacteria. In the invention, the used nano peroxide particles are stable solid particles, and have higher stability compared with volatile organic or hydrogen peroxide antibacterial agents, so that active oxygen species can be continuously and slowly released after meeting water, thereby achieving the effect of slow-release sterilization.
In step 2, 0.05-2 parts of dispersing agent and 3-10 parts of humectant are dissolved in water to prepare a first solution, and then 0.01-3 parts of nano peroxide particles with rich hydroxyl groups on the surface are washed and separated and then directly added into the first solution; uniformly suspending the peroxide particles with the surfaces rich in hydroxyl groups in the first solution after stirring and ultrasonic dispersion for 10-30min to obtain a nano peroxide particle suspension;
specifically, as described above, the nanoperoxide particles prepared in step 1 have abundant OH on the surface - And directly carrying out preparation of the nano peroxide particle suspension after washing and separation, wherein the nano peroxide particles with rich hydroxyl groups on the surfaces are not dried and are directly mixed with a dispersing agent and a humectant in a wet product manner, so that the hydroxyl groups formed on the surfaces of the nano peroxide particles in the step 1 are effectively retained, and the peroxide particles with rich hydroxyl groups on the surfaces are uniformly suspended in the first solution and are placed without forming upper and lower layers.
Specifically, the dispersing agent is selected from at least one of polyethylene glycol and polyvinylpyrrolidone, and is preferably polyethylene glycol; the addition amount of the dispersant is 0.05 to 2 parts by mass, preferably 1 part by mass. In the invention, the addition proportion of the dispersing agent is selected to be 0.05-2 parts by mass, because the dispersing agent is mainly an organic matter when the addition proportion of the dispersing agent is more than 2 parts by mass, the excessive dispersing agent added in the process of preparing the nano peroxide particle suspension can cause the problems of flocculation, aggregation and precipitation of products, even colloid formation and the like, thereby leading the flowability of the nano peroxide particle suspension to be poor; in addition, too much dispersant may cause problems such as increased product cost, flammability of the product, and the like. When the addition ratio of the dispersant is less than 0.05 parts by mass, the nanoperoxide particles may not be uniformly suspended in the first solution due to the addition of too little dispersant, and may be left standing to form upper and lower layers.
Specifically, the humectant is selected from at least one of glycerin and propylene glycol, but is not limited thereto, and is more limited to the specific raw materials used in the examples; preferably glycerol; the addition amount of the humectant is 3-10 parts by mass, preferably 5 parts by mass.
Specifically, the nano peroxide particles with rich hydroxyl groups on the surface are washed and separated and then directly added into the first solution, the stirring speed is 180r/min, the ultrasonic frequency is 100Hz, and the dispersion time is 10-30min, but the numerical range is not limited.
In step 3, 0.3-1 part of gel matrix is dissolved in water to prepare a second solution, 0-10 parts of humectant and 0-40 parts of water are added into the nano peroxide particle suspension to prepare a mixed solution, the mixed solution is slowly added into the second solution, and 0-0.5 part of gel is added after uniform mixing, so that the friendly durable antibacterial disinfection gel is obtained.
Specifically, the gel matrix is selected from at least one of sodium alginate and carbomer, but is not limited to the above, and is not limited to the specific raw materials used in the examples; preferably carbomer; the gel matrix is added in an amount of 0.3 to 1 part by mass, preferably 0.4 part by mass. In the invention, sodium alginate, carbomer or a composition of sodium alginate and carbomer are selected as the thickening agent, so that the thickening and suspending capabilities of the product can be further improved, and the sedimentation of the nano peroxide particles can be effectively inhibited, thereby fully playing the long-term and efficient antibacterial effect of the nano peroxide particles and further enhancing the antibacterial effect of the gel.
Specifically, the gelling agent is selected from at least one of triethanolamine, ethylenediamine, sodium hydroxide and potassium hydroxide, but is not limited thereto, and is not limited to the specific raw materials used in the examples; preferably triethanolamine; the addition amount of the gelling agent is 0-0.5 parts by mass, preferably 0.3 parts by mass.
Specifically, a mixed solution of the nano peroxide particle suspension, the humectant and water is not required to be prepared, the nano peroxide particle suspension can be directly and slowly added into the second solution, and 0-0.5 part of gelling agent is added after uniform mixing to obtain the antibacterial disinfection gel.
Specifically, after the nano peroxide particle suspension or a mixed solution prepared from the nano peroxide particle suspension, 0-10 parts of humectant and 0-40 parts of water is added into the second solution, no gelling agent is needed to be added, and the friendly and durable antibacterial and disinfectant gel is directly obtained.
In step 3 of the present invention, since the friendly durable antibacterial disinfecting gel of the present invention can also be prepared into a compound friendly durable antibacterial disinfecting gel by compounding an antibacterial agent, step 3 can further be:
step 3': preparation of antimicrobial disinfecting gels comprising nanoperoxide particles
According to the mass parts, 0.3-1 part of gel matrix is dissolved in water to prepare a second solution, 0-10 parts of humectant, 0-40 parts of water and a compound antibacterial agent are added into the nano peroxide particle suspension to prepare a mixed solution, the mixed solution is slowly added into the second solution, and 0-0.5 part of gel is added after uniform mixing, so that the friendly type durable antibacterial disinfection gel is obtained. Alternatively, the first and second electrodes may be,
step 3': preparation of antimicrobial disinfecting gels comprising nanoperoxide particles
According to the mass parts, 0.3-1 part of gel matrix is dissolved in water to prepare a second solution, 0-10 parts of humectant, 0-40 parts of water and a compound antibacterial agent are added into the nano peroxide particle suspension to prepare a mixed solution, the mixed solution is slowly added into the second solution, then the compound antibacterial agent is added, and after uniform mixing, 0-0.5 part of gel is added to obtain the friendly and durable antibacterial disinfection gel.
Specifically, the compound antibacterial agent is selected from at least one of hydrogen peroxide and ethanol, but is not limited thereto, and is not limited to the specific raw materials used in the examples.
More specifically, when the compound antibacterial agent is hydrogen peroxide, the mass concentration of the hydrogen peroxide in the antibacterial disinfection gel is not more than 1%; when the compound antibacterial agent is ethanol, the mass concentration of the ethanol in the antibacterial and disinfectant gel is not more than 50%.
In another aspect of the invention, a friendly and durable antibacterial disinfecting gel prepared by the method comprises the following components in parts by weight: 0.01-3 parts of nano peroxide particles with surfaces rich in hydroxyl, 0.05-2 parts of dispersing agent, 3-10 parts of humectant, 0.3-1 part of gel matrix, 0-0.5 part of gel and water;
specifically, the nano-peroxide particles with rich hydroxyl groups on the surface are nano-metal peroxide particles, and the metal peroxide is at least one selected from magnesium peroxide, calcium peroxide and zinc peroxide, but not limited to the nano-metal peroxide particles, and is not limited to the specific raw materials used in the examples.
Specifically, the friendly type durable antibacterial disinfection gel is prepared by the following method:
adding a precipitator into a metal salt solution, mixing and stirring for 15-45 min, adding a hydrogen peroxide solution, continuously mixing and stirring for 45-75 min to fully react, and washing and separating to obtain nano peroxide particles with surfaces rich in hydroxyl groups;
dissolving 0.05-2 parts by mass of a dispersing agent and 3-10 parts by mass of a humectant in water to prepare a first solution, and adding 0.01-3 parts by mass of the nano peroxide particles with the surfaces rich in hydroxyl groups into the first solution; uniformly suspending the nanometer peroxide particles with the surfaces rich in hydroxyl groups in the first solution after stirring and ultrasonic dispersion for 10-30min to obtain a nanometer peroxide particle suspension;
dissolving 0.3-1 part by mass of a gel matrix in water to prepare a second solution, adding 0-10 parts by mass of a humectant and 0-40 parts by mass of water to the suspension of the nano peroxide particles to prepare a mixed solution, slowly adding the mixed solution to the second solution, uniformly mixing, and adding 0-0.5 part by mass of a gelling agent to obtain the antibacterial and disinfectant gel containing the nano peroxide particles.
Specifically, the dispersant is selected from at least one of polyethylene glycol and polyvinylpyrrolidone, but is not limited thereto, and is more limited to the specific raw materials used in the examples; preferably polyethylene glycol; the addition amount of the dispersant is 0.05 to 2 parts by mass, preferably 1 part by mass.
Specifically, the humectant is selected from at least one of glycerol and propylene glycol, but is not limited thereto, and is more limited to the specific raw materials used in the examples; preferably glycerol; the addition amount of the humectant is 3-10 parts by mass, preferably 5 parts by mass.
Specifically, the gel matrix is selected from at least one of sodium alginate and carbomer, but is not limited to the above, and is not limited to the specific raw materials used in the examples; preferably carbomer; the gel matrix is added in an amount of 0.3 to 1 part by mass, preferably 0.4 part by mass.
Specifically, the gelling agent is selected from at least one of triethanolamine, ethylenediamine, sodium hydroxide and potassium hydroxide, but is not limited thereto, and is not limited to the specific raw materials used in the examples; preferably triethanolamine; the addition amount of the gelling agent is 0-0.5 parts by mass, preferably 0.3 parts by mass.
Specifically, the friendly and durable antibacterial disinfecting gel can be further compounded with an antibacterial agent to prepare a compounded antibacterial disinfecting gel, wherein the compounded antibacterial agent is selected from at least one of hydrogen peroxide and ethanol, but is not limited to the above, and is not limited to the specific raw materials used in the embodiment;
more specifically, when the compound antibacterial agent is hydrogen peroxide, the mass concentration of the hydrogen peroxide in the antibacterial disinfection gel is not more than 3%; when the compound antibacterial agent is ethanol, the mass concentration of the ethanol in the antibacterial and disinfectant gel is not more than 50%.
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and do not limit the invention. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
Example 1
Step 1: preparation of nano magnesium peroxide particles with surfaces rich in hydroxyl groups
15.6g Mg (NO) are weighed out 3 ) 2 ·6H 2 Dissolving O in 70mL of deionized water, adding 18mL of ammonia water (25-28 wt%), stirring for reaction for 30min, adding 50mL of hydrogen peroxide (30 wt%), and continuing stirring for reaction for 1 h; separating and washing to obtain the nano magnesium peroxide particles with surfaces rich in hydroxyl.
Step 2: preparation of nano magnesium peroxide particle suspension
Dissolving 3.2g of the nano magnesium peroxide particles with rich hydroxyl on the surface in 160mL of first solution (the first solution contains 15mL of polyethylene glycol and 45mL of glycerol), stirring, and performing ultrasonic dispersion uniformly to obtain a nano magnesium peroxide particle suspension;
and step 3: preparation of nano magnesium peroxide antibacterial disinfection gel
First, 0.6g of carbomer is dissolved in 150mL of deionized water until completely dissolved for later use.
Adding 5mL of glycerol and 25mL of deionized water into 20mL of the nano magnesium peroxide particle suspension, and stirring and uniformly mixing to form a mixed solution; and slowly adding the mixed solution into the carbomer solution, and then dropwise adding 0.5mL of triethanolamine to obtain the nano magnesium peroxide antibacterial disinfecting gel.
Example 2
Step 1: preparation of nano magnesium peroxide particles with surfaces rich in hydroxyl groups
Same as example 1
Step 2: preparation of nano magnesium peroxide particle suspension
Dissolving 0.8g of the nano magnesium peroxide particles with rich hydroxyl groups on the surface in 160mL of first solution (the first solution contains 15mL of polyethylene glycol and 45mL of glycerol), stirring, and performing ultrasonic dispersion to obtain a nano magnesium peroxide particle suspension;
and step 3: preparation of nano magnesium peroxide antibacterial disinfecting gel
First, 0.6g of carbomer is dissolved in 150mL of deionized water until completely dissolved for later use.
4mL of the nano magnesium peroxide particle suspension is slowly added into carbomer solution to obtain the nano magnesium peroxide antibacterial disinfecting gel.
Example 3
Step 1: preparation of nano magnesium peroxide particles with surfaces rich in hydroxyl groups
Same as example 1
And 2, step: preparation of nano magnesium peroxide particle suspension
Taking 6g of the mixed solution, separating and washing to obtain nano magnesium peroxide particles with surfaces rich in hydroxyl, dissolving the nano magnesium peroxide particles in 160mL of first solution (the first solution contains 3.2mL of polyethylene glycol and 15mL of glycerol), stirring, and uniformly dispersing by ultrasonic to obtain a nano magnesium peroxide particle suspension;
and step 3: preparation of nano magnesium peroxide antibacterial disinfection gel
First, 2g of carbomer was dissolved in 150mL of deionized water until completely dissolved for use.
And slowly adding the nano magnesium peroxide particle suspension into a carbomer solution to obtain the nano magnesium peroxide antibacterial and disinfectant gel.
Example 4
Step 1: preparation of nano magnesium peroxide particles with surfaces rich in hydroxyl groups
Same as example 1
Step 2: preparation of nano magnesium peroxide particle suspension
Dissolving 6g of the nano magnesium peroxide particles with the surfaces rich in hydroxyl groups in 160mL of first solution (the first solution contains 3.2mL of polyethylene glycol and 15mL of glycerol), stirring, and performing ultrasonic dispersion to obtain a nano magnesium peroxide particle suspension;
and 3, step 3: preparation of nano magnesium peroxide antibacterial disinfecting gel
First, 2g of carbomer was dissolved in 150mL of deionized water until completely dissolved for use.
Adding 5mL of glycerol and 25mL of deionized water into the nano magnesium peroxide particle suspension, and uniformly stirring to form a mixed solution; and slowly adding the mixed solution into the carbomer solution, and then dropwise adding 0.5mL of triethanolamine to obtain the nano magnesium peroxide antibacterial disinfecting gel.
Example 5
Step 1: preparation of nano magnesium peroxide particles with surfaces rich in hydroxyl groups
Same as example 1
Step 2: preparation of nano magnesium peroxide particle suspension
Dissolving 6g of the nano magnesium peroxide particles with the surfaces rich in hydroxyl groups in 160mL of first solution (the first solution contains 3.2mL of polyethylene glycol and 15mL of glycerol), stirring, and performing ultrasonic dispersion to obtain a nano magnesium peroxide particle suspension;
and step 3: preparation of nano magnesium peroxide antibacterial disinfecting gel
First, 2g of carbomer was dissolved in 150mL of deionized water until completely dissolved for use.
And (3) slowly adding 80mL of the nano magnesium peroxide particle suspension into a carbomer solution, and then dropwise adding 0.6mL of triethanolamine to obtain the nano magnesium peroxide antibacterial disinfecting gel.
Example 6
Step 1: preparation of nano magnesium peroxide particles with surfaces rich in hydroxyl groups
15.6g Mg (NO) are weighed out 3 ) 2 ·6H 2 Dissolving O in 70mL of deionized water, adding 9mL of ammonia water (25-28 wt%), stirring for reaction for 30min, then adding 6mL of hydrogen peroxide (30 wt%), and continuing stirring for reaction for 1 h; separating and washing to obtain the nanometer magnesium peroxide particles with surfaces rich in hydroxyl.
Step 2: preparation of nano magnesium peroxide particle suspension
Same as example 1
And step 3: preparation of nano magnesium peroxide antibacterial disinfection gel
Same as example 1
Example 7
Step 1: preparation of nano magnesium peroxide particles with surfaces rich in hydroxyl groups
15.6g Mg (NO) are weighed out 3 ) 2 ·6H 2 Dissolving O in 70mL of deionized water, adding 9mL of ammonia water (25-28 wt%), stirring for reaction for 30min, then adding 60mL of hydrogen peroxide (30 wt%), and continuing stirring for reaction for 1 h; separating and washing to obtain the nanometer magnesium peroxide particles with surfaces rich in hydroxyl.
Step 2: preparation of nano magnesium peroxide particle suspension
Same as example 1
And step 3: preparation of nano magnesium peroxide antibacterial disinfection gel
Same as example 1
Example 8
Step 1: preparation of nano magnesium peroxide particles with surfaces rich in hydroxyl groups
Same as example 1
Step 2: preparation of nano magnesium peroxide particle suspension
Same as example 1
And 3, step 3: preparation of nano magnesium peroxide-hydrogen peroxide compound antibacterial disinfection gel
First, 0.8g of carbomer is dissolved in 150mL of deionized water until completely dissolved for later use.
Adding 5mL of glycerol, 32mL of deionized water and 3mL of hydrogen peroxide (30 wt%) into 10mL of the nano magnesium peroxide suspension, and uniformly stirring to form a mixed solution; slowly adding the mixture into carbomer solution, and then dropwise adding 0.6mL of triethanolamine to obtain the nano magnesium peroxide-hydrogen peroxide compound antibacterial disinfecting gel.
Example 9
Step 1: preparation of nano magnesium peroxide particles with surfaces rich in hydroxyl groups
Same as example 1
Step 2: preparation of nano magnesium peroxide particle suspension
Same as example 1
And step 3: preparation of nano magnesium peroxide-hydrogen peroxide compound antibacterial disinfection gel
First, 0.8g of carbomer is dissolved in 150mL of deionized water until completely dissolved for later use.
Adding 5mL of glycerol, 32mL of deionized water and 7mL of hydrogen peroxide (30 wt%) into 10mL of the nano magnesium peroxide suspension, and uniformly stirring to form a mixed solution; slowly adding the mixture into carbomer solution, and then dropwise adding 0.6mL of triethanolamine to obtain the nano magnesium peroxide-hydrogen peroxide compound antibacterial and disinfectant gel.
Example 10
Step 1: preparation of nano magnesium peroxide particles with surfaces rich in hydroxyl groups
Same as example 1
And 2, step: preparation of nano magnesium peroxide particle suspension
Same as example 1
And step 3: preparation of nano magnesium peroxide-ethanol compound antibacterial disinfection gel
First, 1g of carbomer is dissolved in 80mL of deionized water until completely dissolved for later use.
And adding 5mL of glycerol, 14mL of deionized water and 100mL of absolute ethanol into 1mL of the nano magnesium peroxide particle suspension, uniformly stirring, slowly adding the mixture into a carbomer solution, and then dropwise adding 1mL of triethanolamine to obtain the nano magnesium peroxide-ethanol compound antibacterial and disinfectant gel.
Example 11
Step 1: preparation of nano magnesium peroxide particles with surfaces rich in hydroxyl groups
12.4g of MgCl were weighed 2 ·6H 2 Dissolving O in 60mL of deionized water, adding 10mL of polyethylene glycol, uniformly stirring, adding a mixed solution of 4.9g of NaOH and 15mL of water, stirring for reaction for 30min, then adding 50mL of hydrogen peroxide (30 wt%), and continuously stirring for reaction for 2 h; separating and washing to obtain the nanometer magnesium peroxide particles with surfaces rich in hydroxyl.
Step 2: preparation of nano magnesium peroxide particle suspension
Dissolving 3g of the nano magnesium peroxide particles with the surfaces being rich in hydroxyl groups in 20mL of first solution (the first solution contains 0.2g of polyvinylpyrrolidone and 10mL of propylene glycol), stirring, and performing ultrasonic dispersion to obtain a nano magnesium peroxide particle suspension;
and step 3: preparation of nano magnesium peroxide antibacterial disinfection gel
Firstly, 1g of sodium alginate is dissolved in 80mL of deionized water until completely dissolved for later use.
Slowly adding the nano magnesium peroxide particle suspension into a sodium alginate solution to obtain the nano magnesium peroxide antibacterial disinfection gel.
Example 12
Step 1: preparation of Nano calcium peroxide particles with surface richly containing hydroxyl 4.8g Ca (NO) is weighed 3 ) 2 ·4H 2 Dissolving O in 40mL of water, adding a mixed solution of 1.6g of NaOH and 10mL of water, stirring for reacting for 30min, then adding 3mL of hydrogen peroxide (30 wt%), and continuously stirring for reacting for 5 h; separating and washing to obtain the nanometer calcium peroxide particles with surfaces rich in hydroxyl.
Step 2: preparation of nano calcium peroxide particle suspension
Dissolving 0.1g of the nano calcium peroxide particles with rich hydroxyl groups on the surface in 100mL of first solution (the first solution contains 15mL of polyethylene glycol and 45mL of glycerol), stirring, and performing ultrasonic dispersion to obtain a nano calcium peroxide particle suspension;
and step 3: preparation of nano calcium peroxide-ethanol compound antibacterial disinfection gel
First 0.9g carbomer is dissolved in 50mL deionized water until completely dissolved for use.
And (3) adding 5mL of glycerol, 25mL of deionized water and 100mL of absolute ethyl alcohol into 20mL of the nano calcium peroxide particle suspension, uniformly stirring to form a mixed solution, and slowly adding the mixed solution into the sodium alginate solution to obtain the nano calcium peroxide-ethyl alcohol compound antibacterial disinfection gel.
Example 13
Step 1: preparation of nano magnesium peroxide particles and calcium peroxide particles with surfaces rich in hydroxyl groups
Same as example 1 and example 12
Step 2: preparation of suspension of nano magnesium peroxide particles and suspension of calcium peroxide particles
Same as example 1 and example 12
And step 3: compound antibacterial disinfection gel of nano magnesium peroxide-nano calcium peroxide
First, 0.7g of carbomer is dissolved in 150mL of deionized water until completely dissolved for later use.
Mixing 10mL of the nano magnesium peroxide particle suspension and 20mL of the nano calcium peroxide particle suspension, adding 5mL of glycerol and 10mL of deionized water, and stirring uniformly to form a mixed solution; slowly adding the mixed solution into the carbomer solution, and then dropwise adding 0.5mL of triethanolamine to obtain the nano magnesium peroxide-nano calcium peroxide compound antibacterial and disinfectant gel.
Example 14
Step 1: preparation of nano zinc peroxide particles with rich hydroxyl groups on surfaces
Weighing 6g Zn (NO) 3 ) 2 ·6H 2 Dissolving O in 40mL of water, adding 4mL of ammonia water (25-28 wt%), stirring for reaction for 30min, then adding 5mL of hydrogen peroxide (30 wt%), and continuing stirring for reaction for 3 h; separating and washing to obtain the nano zinc peroxide particles with surfaces rich in hydroxyl groups.
Step 2: preparation of suspension of nano zinc peroxide particles
Dissolving 0.5g of the nano zinc peroxide particles with the surfaces rich in hydroxyl groups into 40mL of first solution (the first solution contains 0.1g of polyvinylpyrrolidone and 15mL of glycerol), stirring, and performing ultrasonic dispersion to obtain a nano zinc peroxide particle suspension;
and step 3: nano zinc peroxide-hydrogen peroxide compound antibacterial disinfection gel
Firstly, 0.7g of sodium alginate is dissolved in 50mL of deionized water until the sodium alginate is completely dissolved for later use.
Slowly adding the nano zinc peroxide particle suspension into a carbomer solution, and adding 7mL hydrogen peroxide (30 wt%) to obtain the nano zinc peroxide-hydrogen peroxide compound antibacterial and disinfectant gel.
It should be noted that the salts used in the preparation of the nano-sized metal peroxide particles in examples 1 to 14 are not limited to the above-described Mg (NO) 3 ) 2 ·6H 2 O、MgCl 2 ·6H 2 O、Ca(NO 3 ) 2 ·4H 2 O、Zn(NO 3 ) 2 ·6H 2 Specific metal salts such as O, etc., and may be selected from other nitrates, chlorides, sulfates, acetates and their hydrates of magnesium, calcium and zinc.
Comparative example 1
Dissolving 3.2g of industrial nano magnesium peroxide particles in 160mL of first solution (the first solution contains 15mL of polyethylene glycol and 45mL of glycerol), stirring, and uniformly dispersing by ultrasonic to obtain an industrial nano magnesium peroxide suspension;
then 0.6g of carbomer is dissolved in 150mL of deionized water until completely dissolved for later use.
And (3) slowly adding 20mL of the industrial nano magnesium peroxide suspension into the carbomer solution, and then dropwise adding 0.5mL of triethanolamine to obtain the nano magnesium peroxide-friendly durable antibacterial disinfection gel.
Comparative example 2
Dissolving 15mL of polyethylene glycol and 45mL of glycerol in water to form 160mL of first solution;
dissolving 0.6g of carbomer in 150mL of deionized water until the carbomer is completely dissolved for later use;
taking 20mL of the first solution, adding 5mL of glycerol and 25mL of deionized water, and stirring and uniformly mixing to form a mixed solution; and slowly adding the mixed solution into the carbomer solution to obtain the gel preparation.
Test examples
The sterilization effect of the examples 1-14 and the comparative examples 1-2 is detected by the disinfection technical specification standard:
example 1: the killing effect of the compound on staphylococcus aureus is detected according to the disinfection technical specification (2.1.1), and the killing rate reaches over 90 percent after 4 hours of action.
Example 2: the killing effect of the compound on escherichia coli is detected according to the disinfection technical specification (2.1.1), and the killing rate is over 99 percent after 4 hours of action.
Example 3: the killing effect of the compound on escherichia coli is detected according to the disinfection technical specification (2.1.1), and the killing rate is over 99 percent after 1 hour of action.
Example 4: the sterilization effect of the composition on escherichia coli is detected according to the sterilization technical specification (2.1.1), and the sterilization rate reaches over 99 percent after 1 hour of sterilization.
Example 5: the sterilization effect of the composition on escherichia coli is detected according to the sterilization technical specification (2.1.1), and the sterilization rate reaches over 99 percent after 1 hour of sterilization.
Example 6: the sterilization effect of the composition on escherichia coli is detected according to the sterilization technical specification (2.1.1), and the sterilization rate reaches over 99 percent after 1 hour of sterilization.
Example 7: the killing effect of the compound on escherichia coli is detected according to the disinfection technical specification (2.1.1), and the killing rate is over 99 percent after 1 hour of action.
Example 8: the sterilization effect of the composition on escherichia coli is detected according to the sterilization technical specification (2.1.1), and the sterilization rate reaches over 99 percent after 1 hour of sterilization.
Example 9: the sterilization effect of the composition on escherichia coli is detected according to the sterilization technical specification (2.1.1), and the sterilization rate reaches over 99 percent after 1 hour of sterilization.
Example 10: the sterilization effect of the composition on escherichia coli is detected according to the sterilization technical specification (2.1.1), and the sterilization rate reaches over 99 percent after 1 hour of sterilization.
Example 11: the sterilization effect of the composition on escherichia coli is detected according to the sterilization technical specification (2.1.1), and the sterilization rate reaches over 99 percent after 4 hours of sterilization.
Example 12: after the visible light is irradiated for 30min, the killing rate of the Escherichia coli reaches more than 99 percent.
Example 13: the sterilization effect of the composition on escherichia coli is detected according to the sterilization technical specification (2.1.1), and the sterilization rate reaches over 99 percent after 1 hour of sterilization.
Example 14: the sterilization effect of the composition on escherichia coli is detected according to the sterilization technical specification (2.1.1), and the sterilization rate reaches over 99 percent after 1 hour.
Comparative example 1: the killing effect of the compound on staphylococcus aureus is detected according to the disinfection technical specification (2.1.1), and the killing rate is less than 50% after 4 hours of action.
Comparative example 2: the killing effect of the compound on escherichia coli is detected according to the disinfection technical specification (2.1.1), and the bacteria loss rate (killing rate) is basically unchanged after 1 h.
The following conclusions can be drawn from the above examples 1 to 14, comparative examples 1 to 2, test examples, and FIGS. 2 and 3:
as shown in fig. 2 and 3, which are characteristic diagrams of XRD and SEM of a nano magnesium peroxide particle with rich hydroxyl group on the surface prepared according to step 1 of example 1: as can be seen from FIG. 2, the magnesium peroxide particles can be prepared by step 1, and the XRD peaks thereof correspond to the magnesium peroxide card of JCPDS 01-076-1363. As can be seen from FIG. 3, the nano magnesium peroxide particles prepared in step 1 are spherical-like nanoparticles with regular morphology and uniform particle size, and the particle size is about 30-70 nm; as a solid material, the peroxide is more stable than other liquid antibacterial components, such as volatile ethanol or easily-decomposed hydrogen peroxide, so that the solid nano magnesium peroxide particles can be sufficiently contacted with water after contacting with water, thereby effectively and slowly releasing active oxygen species.
The bactericidal effect detected by the test example can be seen as follows: from examples 1 to 11, the nano magnesium peroxide antibacterial disinfection gel prepared by using the nano magnesium peroxide particles with rich hydroxyl groups on the surfaces has strong sterilization effect; wherein, 0.45% of hydrogen peroxide is added as compound antibacterial disinfection gel in the embodiment 8, 1% of hydrogen peroxide is added as compound antibacterial disinfection gel in the embodiment 9, 50% of ethanol is added as compound antibacterial disinfection gel in the embodiment 10, the compound antibacterial disinfection gel has an additive sterilization effect, the sterilization effect on escherichia coli is achieved, and the detection sterilization rate reaches more than 99% after 1 hour of action; the formula system is stable, and the ethanol with the mass concentration of 50% is added, so that the sterilization effect is ensured, and the stability is also realized. From example 12, it can be seen that the nano calcium peroxide antiseptic gel prepared by using the nano calcium peroxide particles with rich hydroxyl groups on the surface has a strong sterilization effect, and the sterilization effect is slightly inferior to that of the nano magnesium peroxide antiseptic gel. From example 13, it can be seen that the nano magnesium peroxide-nano calcium peroxide compounded antibacterial and disinfectant gel prepared by simultaneously using the nano magnesium peroxide and the calcium peroxide particles with surfaces rich in hydroxyl groups also has a very strong bactericidal effect, which indicates that the effect can achieve a certain addition effect after the two are mixed. From example 14, it can be seen that the nano zinc peroxide-hydrogen peroxide compounded antibacterial disinfecting gel prepared by using the nano zinc peroxide particles with rich hydroxyl groups on the surfaces also has a very strong bactericidal effect, wherein the mass concentration of hydrogen peroxide is 1%, which indicates that the effect can achieve a certain addition effect after the two are mixed. Comparing comparative examples 1-2, it can be seen that the antibacterial disinfecting gel prepared by using industrial nano magnesium peroxide particles and the gel prepared without adding nano magnesium peroxide particles hardly achieve the bactericidal effect of example 1, and further, it is described that the slow-release antibacterial disinfecting gel prepared by using nano peroxide particles with rich hydroxyl groups on the surface is a gel product with excellent antibacterial performance, mildness and long-lasting effect.
Although embodiments of the present invention have been shown and described above, it will be understood that the above embodiments are exemplary and not to be construed as limiting the present invention, and that those skilled in the art may make variations, modifications, substitutions and alterations within the scope of the present invention without departing from the spirit and scope of the present invention. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (10)
1. A preparation method of a friendly type durable antibacterial disinfection gel is characterized by comprising the following steps:
adding a precipitator into a metal salt solution, mixing and stirring for 15-45 min, adding a hydrogen peroxide solution, continuously stirring for 45-75 min to fully react, and washing and separating to obtain nano peroxide particles with surfaces rich in hydroxyl groups;
dissolving 0.05-2 parts by mass of a dispersing agent and 3-10 parts by mass of a humectant in water to prepare a first solution, and adding 0.01-3 parts by mass of the nano peroxide particles with the surfaces rich in hydroxyl groups into the first solution; uniformly suspending the nanometer peroxide particles with the surfaces rich in hydroxyl groups in the first solution after stirring and ultrasonic dispersion for 10-30min to obtain a nanometer peroxide particle suspension;
dissolving 0.3-1 parts by mass of gel matrix in water to prepare a second solution, adding 0-10 parts by mass of humectant and 0-40 parts by mass of water to the nano peroxide particle suspension to prepare a mixed solution, slowly adding the mixed solution to the second solution, uniformly mixing, and adding 0-0.5 part by mass of gel to obtain the antibacterial and disinfectant gel containing the nano peroxide particles;
the nano peroxide particles with the surfaces being rich in hydroxyl groups are nano metal peroxide particles, and the metal peroxide is at least one selected from magnesium peroxide, calcium peroxide and zinc peroxide;
the metal salt is selected from at least one of nitrate, chloride, sulfate and acetate of magnesium, calcium and zinc;
the precipitant is selected from at least one of ammonia water, sodium hydroxide and potassium hydroxide;
the dispersing agent is selected from at least one of polyethylene glycol and polyvinylpyrrolidone;
the humectant is at least one selected from glycerol and propylene glycol;
the gel matrix is at least one of sodium alginate and carbomer;
the gelling agent is at least one of triethanolamine, ethylenediamine, sodium hydroxide and potassium hydroxide.
2. The method for preparing a friendly, durable, antibacterial, disinfecting gel as claimed in claim 1, wherein said dispersing agent is polyethylene glycol; the humectant is glycerol; the gel matrix is carbomer; the gel is triethanolamine.
3. The method for preparing a friendly durable antibacterial disinfectant gel according to claim 1, wherein said adding 0-10 parts humectant and 0-40 parts water into said nano peroxide particle suspension to prepare a mixed solution, slowly adding said mixed solution into said second solution, further comprising:
adding 0-10 parts of humectant, 0-40 parts of water and a compound antibacterial agent into the nano peroxide particle suspension to prepare a mixed solution, and slowly adding the mixed solution into the second solution; alternatively, the first and second electrodes may be,
and adding 0-10 parts of humectant and 0-40 parts of water into the nano peroxide particle suspension to prepare a mixed solution, slowly adding the mixed solution into the second solution, and then adding the compound antibacterial agent.
4. The method for preparing the friendly and durable antibacterial and disinfectant gel according to claim 3, wherein the compound antibacterial agent is at least one selected from hydrogen peroxide and ethanol;
wherein, when the compound antibacterial agent is hydrogen peroxide, the mass concentration of the hydrogen peroxide in the antibacterial and disinfectant gel is not more than 1%; when the compound antibacterial agent is ethanol, the mass concentration of the ethanol in the antibacterial and disinfectant gel is not more than 50%.
5. The method of claim 1, wherein the metal salt to precipitant molar ratio is 1: 2-1: 4, the molar ratio of the metal salt to the hydrogen peroxide is 1: 1-1: 10.
6. the method for preparing friendly durable antibacterial disinfecting gel according to claim 1, characterized in that the metal salt is at least one of nitrate and chloride salts of magnesium, calcium and zinc; the precipitant is ammonia water.
7. The friendly type durable antibacterial disinfection gel is characterized by comprising the following components in parts by weight: 0.01-3 parts of nano peroxide particles with surfaces rich in hydroxyl, 0.05-2 parts of dispersing agent, 3-10 parts of humectant, 0.3-1 part of gel matrix, 0-0.5 part of gel and water;
the nano peroxide particles with surfaces rich in hydroxyl groups are nano metal peroxide particles, and the metal peroxide is selected from at least one of magnesium peroxide, calcium peroxide and zinc peroxide;
the dispersing agent is selected from at least one of polyethylene glycol and polyvinylpyrrolidone;
the humectant is at least one selected from glycerol and propylene glycol;
the gel matrix is at least one of sodium alginate and carbomer;
the gelling agent is at least one of triethanolamine, ethylenediamine, sodium hydroxide and potassium hydroxide;
the preparation method of the nano peroxide particles with the surfaces rich in hydroxyl comprises the following steps: adding a precipitator into the metal salt solution, mixing and stirring for 15-45 min, adding a hydrogen peroxide solution, continuously mixing and stirring for 45-75 min to enable the mixture to react fully, and washing and separating to obtain the nano peroxide particles with the surfaces rich in hydroxyl groups.
8. The friendly, durable antimicrobial antiseptic gel of claim 7 wherein said antimicrobial antiseptic gel is prepared by the following method:
dissolving 0.05-2 parts by mass of a dispersing agent and 3-10 parts by mass of a humectant in water to prepare a first solution, and adding 0.01-3 parts by mass of the nano peroxide particles with the surfaces rich in hydroxyl groups into the first solution; uniformly suspending the nanometer peroxide particles with the surfaces being rich in hydroxyl groups in the first solution after stirring and ultrasonic dispersion for 10-30min to obtain a nanometer peroxide particle suspension;
dissolving 0.3-1 part by mass of a gel matrix in water to prepare a second solution, adding 0-10 parts by mass of a humectant and 0-40 parts by mass of water to the suspension of the nano peroxide particles to prepare a mixed solution, slowly adding the mixed solution to the second solution, uniformly mixing, and adding 0-0.5 part by mass of a gelling agent to obtain the antibacterial and disinfectant gel containing the nano peroxide particles.
9. The friendly, durable antimicrobial disinfecting gel of claim 7 wherein said dispersing agent is polyethylene glycol; the humectant is glycerol; the gel matrix is carbomer; the gel is triethanolamine.
10. The friendly durable antibacterial disinfecting gel of claim 7, further comprising a compound antibacterial agent selected from at least one of hydrogen peroxide and ethanol;
wherein, when the compound antibacterial agent is hydrogen peroxide, the mass concentration of the hydrogen peroxide in the antibacterial and disinfectant gel is not more than 1%; when the compound antibacterial agent is ethanol, the mass concentration of the ethanol in the antibacterial and disinfectant gel is not more than 50%.
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