CN113423822A - Psca car-t细胞 - Google Patents

Psca car-t细胞 Download PDF

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Publication number
CN113423822A
CN113423822A CN201980092120.XA CN201980092120A CN113423822A CN 113423822 A CN113423822 A CN 113423822A CN 201980092120 A CN201980092120 A CN 201980092120A CN 113423822 A CN113423822 A CN 113423822A
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China
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seq
cells
dose
subject
twice
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CN201980092120.XA
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Chinese (zh)
Inventor
P·伍达得
A·E·福斯特
D·M·斯班赛
O·加德纳
W·格罗斯曼
M·R·柯林森-波茨
A·莫斯利
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Regeneron Pharmaceuticals Inc
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Bellicum Pharmaceuticals Inc
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4274—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; Prostatic acid phosphatase [PAP]; Prostate-specific G-protein-coupled receptor [PSGR]
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CN201980092120.XA 2018-12-13 2019-12-12 Psca car-t细胞 Pending CN113423822A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862779394P 2018-12-13 2018-12-13
US62/779,394 2018-12-13
PCT/US2019/065901 WO2020123766A1 (en) 2018-12-13 2019-12-12 Psca car-t cells

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CN113423822A true CN113423822A (zh) 2021-09-21

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US (2) US20220062338A1 (https=)
EP (1) EP3894545A4 (https=)
JP (2) JP2022514477A (https=)
CN (1) CN113423822A (https=)
AU (1) AU2019397048A1 (https=)
CA (1) CA3122421A1 (https=)
WO (1) WO2020123766A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3146533A1 (en) * 2019-05-31 2020-12-03 Argus Control Systems Ltd. Plant health monitoring apparatus and methods
US20250302763A1 (en) 2024-02-22 2025-10-02 Capstan Therapeutics, Inc. Immune engineering amplification

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050221400A1 (en) * 2003-05-30 2005-10-06 Agensys, Inc. Antibodies and related molecules that bind to PSCA proteins
CN101223191A (zh) * 2005-04-14 2008-07-16 阿根西斯公司 与psca蛋白结合的抗体和相关分子
US20100297004A1 (en) * 2007-09-04 2010-11-25 The Regents Of The University Of California High affinity anti-prostate stem cell antigen (psca) antibodies for cancer targeting and detection
US20160058857A1 (en) * 2014-09-02 2016-03-03 Bellicum Pharmaceuticals, Inc. Costimulation of chimeric antigen receptors by myd88 and cd40 polypeptides
CN106132423A (zh) * 2014-02-14 2016-11-16 贝里坤制药股份有限公司 用诱导型嵌合多肽活化t细胞的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170166877A1 (en) * 2015-12-14 2017-06-15 Bellicum Pharmaceuticals, Inc. Dual controls for therapeutic cell activation or elimination

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050221400A1 (en) * 2003-05-30 2005-10-06 Agensys, Inc. Antibodies and related molecules that bind to PSCA proteins
CN101223191A (zh) * 2005-04-14 2008-07-16 阿根西斯公司 与psca蛋白结合的抗体和相关分子
US20100297004A1 (en) * 2007-09-04 2010-11-25 The Regents Of The University Of California High affinity anti-prostate stem cell antigen (psca) antibodies for cancer targeting and detection
CN106132423A (zh) * 2014-02-14 2016-11-16 贝里坤制药股份有限公司 用诱导型嵌合多肽活化t细胞的方法
US20160058857A1 (en) * 2014-09-02 2016-03-03 Bellicum Pharmaceuticals, Inc. Costimulation of chimeric antigen receptors by myd88 and cd40 polypeptides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AARON E. FOSTER等: "Regulated Expansion and Survival of Chimeric Antigen Receptor-Modified T Cells Using Small Molecule-Dependent Inducible MyD88/CD40", 《MOLECULAR THERAPY》, vol. 25, no. 9, XP055497492, DOI: 10.1016/j.ymthe.2017.06.014 *
武少贤等: "CAR-T细胞治疗实体肿瘤的新策略", 《中国肿瘤生物治疗杂志》, vol. 25, no. 9 *
陈慕华等: "CAR-T细胞治疗消化系统肿瘤的研究进展", 《生命科学》, vol. 29, no. 9 *

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Publication number Publication date
JP2022514477A (ja) 2022-02-14
JP2025028133A (ja) 2025-02-28
US20260055161A1 (en) 2026-02-26
EP3894545A4 (en) 2022-11-16
EP3894545A1 (en) 2021-10-20
AU2019397048A1 (en) 2021-06-24
US20220062338A1 (en) 2022-03-03
CA3122421A1 (en) 2020-06-18
WO2020123766A1 (en) 2020-06-18

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