CN113398059A - 一种含有口腔益生菌的牙膏及其制备方法 - Google Patents
一种含有口腔益生菌的牙膏及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种含有口腔益生菌的牙膏及其制备方法,所述牙膏包括如下重量份原料:宝乐果粉40~60份、木姜叶柯30~60份、益生菌10~20份、柳叶蜡梅1~5份、低聚甘露糖1~5份、乌药叶1~5份、初乳碱性蛋白1~5份。本发明采用具有抗氧化作用的宝乐果粉和木姜叶柯,达到治疗口腔溃疡的作用,可以减少益生菌的用量,低聚甘露糖还能够促进益生菌的生长,使各益生菌之间发挥协调作用,同时通过含有的柳叶蜡梅、米糠脂肪烷醇、乌药叶和初乳碱性蛋白均具有治疗口腔溃疡的作用,进而有效预防和改善口腔溃疡。
Description
技术领域
本发明属于牙膏技术领域,具体涉及一种含有口腔益生菌的牙膏及其制备方法。
背景技术
近年来,随着科学家对微生物研究的不断深入,疾病与微生物的变化紧密相连,口腔疾病患病率和发病率特别高,是主要的公共卫生问题之一而口腔作为消化道的第一道关口,寄居着数百种细菌,比如幽门螺杆菌,具核梭杆菌以及牙龈卟啉单胞菌等等口腔是人体健康的第一道关口,人体口腔环境是一个含有多种微生物的复杂的生态系统。其中某些对口腔健康不利的微生物的过量生长繁殖会导致龋齿、牙周炎和口臭的发生。牙周病是发生在牙齿周围组织的疾病,主要分为牙龈炎和牙周炎,其中牙龈炎主要破坏牙龈组织,牙周炎病变主要侵犯牙龈、牙周膜、牙槽骨和牙骨质。牙周病可导致牙龈出血、口臭、牙齿松动和移位等;个体的口腔健康行为直接影响到个体的口腔健康状况。而个体的口腔健康行为受个体因素、家庭因素和社会因素等的影响。口腔健康教育和口腔健康促进就是通过改善人群的口腔健康行为,达到改善人群的口腔健康状况的根本目的。所以,只有深刻认识口腔健康行为的各种影响因素,才能为更好地实施口腔健康教育和口腔健康促进提供依据。
通过服用抗生素的治疗方式会破坏口腔生态系统的平衡,而且治疗效果也往往不尽如人意,另外现有的牙膏对维护口腔的菌群平衡,影响不大,无法从根本上改善口腔环境。
发明内容
发明目的:为了解决现有技术中存在的问题,本发明提供了一种含有口腔益生菌的牙膏及其制备方法,所述牙膏能够显著改善口腔环境。
技术方案:一种含有口腔益生菌的牙膏,所述牙膏包括如下重量份原料:
牙膏基料100份、锶盐0.5~5份、钾盐0.5~5份、益生菌10~20份、金银花10~15份、洋金花9~14份、连翘8~12份、赶黄草2~5份、明日叶2~4份、枇杷花2~3份。
优选的,所述钾盐为氯化钾,锶盐为氯化锶。
优选的,所述益生菌为动物双歧杆菌TR-P03、鼠李糖乳杆菌TR-08、嗜酸乳杆菌TR-P06、长双歧杆菌TR-17、乳双歧杆菌TR101、短双歧杆菌TR-R03中的一种或多种的混合物。
优选的,所述益生菌包括如下质量比原料:
10-40份的动物双歧杆菌TR-P03、10-20份的鼠李糖乳杆菌TR-08、10-30份的嗜酸乳杆菌TR-P06、5-15份的长双歧杆菌TR-17、15-25份的乳双歧杆菌TR101和10-20份的短双歧杆菌TR-R03。
所述含有口腔益生菌的牙膏的制备方法,包括以下步骤:
(1)将金银花、洋金花、连翘、赶黄草、明日叶和枇杷花粉碎,混合,发酵,压滤,得到中药汁;
(2)取牙膏基料,加入锶盐、钾盐、中药汁和益生菌,搅拌均匀后,得到混合物;
(3)对混合物进行浓缩,获得膏体,研磨后制得牙膏。
优选的,步骤(1)中,所述发酵的温度为25-35℃,发酵的时间为24-48h。
优选的,步骤(1)中,所述发酵采用纤维素酶和蛋白酶进行发酵,两者的加入量为0.02-0.08%。
本发明所制备的牙膏通过添加益生菌可有效的降低口腔内的细菌滋生,维持口腔生态平衡,降低牙菌斑的机率,从而降低牙周病的患病率;可有效的减少和防止使用者出现过敏的现象;牙膏的制备方法简单,可批量生产。
有益效果:与现有技术相比,本发明具有如下优势:
1)本发明所制备的牙膏通过添加益生菌可有效的降低口腔内的细菌滋生,维持口腔生态平衡,降低牙菌斑的机率,从而降低牙周病的患病率;
2)本发明的牙膏添加有钾盐和锶盐,锶盐具有封闭牙本质开口的小管的孔道,从而组织阻止酸痛的功效,钾盐中的钾离子进入牙本质的小管可降低牙本质的通透性,并与神经末梢有亲和作用,改善神经脉冲的传递。
3)本发明牙膏中还添加有经过发酵的中草药,各中草药作用互补,协同作用,经过发酵后,可以有效释放抗菌和抗过敏成分,并且在一定程度上提高益生菌的活性,最终可极大程度降低口腔内微生物和细菌的滋生,改善口腔环境,改善牙周炎,可有效的减少和防止使用者出现过敏的现象。
综上所述,本发明所制备的牙膏可明显的降低口腔内微生物和细菌的滋生,改善口腔环境,改善和防止牙周病的病率,且制备方法简单,可批量生产。
具体实施方式
下述实施例中所述实验方法,如无特殊说明,均为常规方法;所述试剂和材料,如无特殊说明,均可从商业途径获得。
实施例1
一种含有口腔益生菌的牙膏配方,包括以下重量份的原料:
牙膏基料100份、氯化钾0.5份、氯化钾0.5份、益生菌10份、金银花10份、洋金花9份、连翘8份、赶黄草2份、明日叶2份、枇杷花2份。
益生菌包含10份的动物双歧杆菌TR-P03、10份的鼠李糖乳杆菌TR-08、10份的嗜酸乳杆菌TR-P06、5份的长双歧杆菌TR-17、15份的乳双歧杆菌TR101和10份的短双歧杆菌TR-R03。
制备方法包括以下步骤:
S1,原料的称取,根据重量比例称取原料;
S2,中草药的预处理:将S1中称取的金银花、洋金花、连翘、赶黄草、明日叶份和枇杷花,粉碎,进行搅拌混合,采用纤维素酶和蛋白酶进行发酵,两者的加入量为0.02%进行发酵,发酵的温度为35℃,发酵的时间为24h,最后进行压滤得到中药汁;
S3,混合:将S1中称取的牙膏基料加入搅拌器中,然后先后加入氯化钾、氯化锶、中药汁和益生菌,搅拌均匀后,得到混合物;
S4,真空脱气处理:对S3中的混合物进行抽真空处理,然后脱气,获得膏体,研磨后制得牙膏。
实施例2
一种含有口腔益生菌的牙膏配方,包括以下重量份的原料:
牙膏基料100份、氯化钾5份、氯化钾5份、益生菌20份、金银花15份、洋金花14份、连翘12份、赶黄草5份、明日叶4份、枇杷花3份。
益生菌包含40份的动物双歧杆菌TR-P03、20份的鼠李糖乳杆菌TR-08、30份的嗜酸乳杆菌TR-P06、15份的长双歧杆菌TR-17、25份的乳双歧杆菌TR101和20份的短双歧杆菌TR-R03。
制备方法包括以下步骤:
S1,原料的称取,根据重量比例称取原料;
S2,中草药的预处理:将S1中称取的金银花、洋金花、连翘、赶黄草、明日叶份和枇杷花,粉碎,进行搅拌混合,采用纤维素酶和蛋白酶进行发酵,两者的加入量为0.08%进行发酵,发酵的温度为25℃,发酵的时间为48h,最后进行压滤得到中药汁;
S3,混合:将S1中称取的牙膏基料加入搅拌器中,然后先后加入氯化钾、氯化锶、中药汁和益生菌,搅拌均匀后,得到混合物;
S4,真空脱气处理:对S3中的混合物进行抽真空处理,然后脱气,获得膏体,研磨后制得牙膏。
实施例3
一种含有口腔益生菌的牙膏配方,包括以下重量份的原料:
牙膏基料100份、氯化钾2.5份、氯化钾2.5份、益生菌15份、金银花12份、洋金花11份、连翘10份、赶黄草3份、明日叶3份、枇杷花2.5份。
益生菌包含25份的动物双歧杆菌TR-P03、15份的鼠李糖乳杆菌TR-08、20份的嗜酸乳杆菌TR-P06、10份的长双歧杆菌TR-17、20份的乳双歧杆菌TR101和15份的短双歧杆菌TR-R03。
制备方法包括以下步骤:
S1,原料的称取,根据重量比例称取原料;
S2,中草药的预处理:将S1中称取的金银花、洋金花、连翘、赶黄草、明日叶份和枇杷花,粉碎,进行搅拌混合,采用纤维素酶和蛋白酶进行发酵,两者的加入量为0.05%进行发酵,发酵的温度为30℃,发酵的时间为36h,最后进行压滤得到中药汁;
S3,混合:将S1中称取的牙膏基料加入搅拌器中,然后先后加入氯化钾、氯化锶、中药汁和益生菌,搅拌均匀后,得到混合物;
S4,真空脱气处理:对S3中的混合物进行抽真空处理,然后脱气,获得膏体,研磨后制得牙膏。
实验例
上述三组实施例制备的牙膏为试验组,以市场上购买的普通牙膏(佳洁士全优抗过敏牙膏)作为对照组,对四组患有牙周炎患者进行试验,每组的实验人数为20人,同时在实验前取每个试验者的受试者在实验前,在舌头背部一侧抽吸以收集细菌,然后将收集的样品梯度稀释后用血琼脂培养基在37℃的厌氧条件下进行培养,并在72小时后,计算单位面积内周围有α、γ溶血环或β溶血环的菌落数,3个月对实验者进行好转统计,并对3个月后患者舌头背部的菌落数的再统计,得到下表:
通过上表可知,本发明所制备的牙膏可明显的降低口腔内微生物和细菌的滋生,改善口腔环境,改善牙周炎。
以上所述,仅为本发明较佳的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,根据本发明的技术方案及其发明构思加以等同替换或改变,都应涵盖在本发明的保护范围之内。
Claims (7)
1.一种含有口腔益生菌的牙膏,其特征在于,所述牙膏包括如下重量份原料:
牙膏基料100份、锶盐0.5~5份、钾盐0.5~5份、益生菌10~20份、
金银花10~15份、洋金花9~14份、连翘8~12份、赶黄草2~5份、
明日叶2~4份、枇杷花2~3份。
2.根据权利要求1所述的含有口腔益生菌的牙膏,其特征在于,所述钾盐为氯化钾,锶盐为氯化锶。
3.根据权利要求1所述的含有口腔益生菌的牙膏,其特征在于,所述益生菌为动物双歧杆菌TR-P03、鼠李糖乳杆菌TR-08、嗜酸乳杆菌TR-P06、长双歧杆菌TR-17、乳双歧杆菌TR101、短双歧杆菌TR-R03中的一种或多种的混合物。
4.根据权利要求1所述的含有口腔益生菌的牙膏,其特征在于,所述益生菌包括如下质量比原料:
10-40份的动物双歧杆菌TR-P03、10-20份的鼠李糖乳杆菌TR-08、10-30份的嗜酸乳杆菌TR-P06、5-15份的长双歧杆菌TR-17、15-25份的乳双歧杆菌TR101和10-20份的短双歧杆菌TR-R03。
5.权利要求1-4任一项所述含有口腔益生菌的牙膏的制备方法,其特征在于,包括以下步骤:
(1)将金银花、洋金花、连翘、赶黄草、明日叶和枇杷花粉碎,混合,发酵,压滤,得到中药汁;
(2)取牙膏基料,加入锶盐、钾盐、中药汁和益生菌,搅拌均匀后,得到混合物;
(3)对混合物进行浓缩,获得膏体,研磨后制得牙膏。
6.根据权利要求5所述的含有口腔益生菌的牙膏的制备方法,其特征在于,步骤(1)中,所述发酵的温度为25-35℃,发酵的时间为24-48h。
7.根据权利要求5所述的含有口腔益生菌的牙膏的制备方法,其特征在于,步骤(1)中,所述发酵采用纤维素酶和蛋白酶进行发酵,两者的加入量为0.02-0.08%。
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