CN113397991A - Whitening, moisturizing and water-locking solid essence mask and preparation method thereof - Google Patents
Whitening, moisturizing and water-locking solid essence mask and preparation method thereof Download PDFInfo
- Publication number
- CN113397991A CN113397991A CN202110804480.7A CN202110804480A CN113397991A CN 113397991 A CN113397991 A CN 113397991A CN 202110804480 A CN202110804480 A CN 202110804480A CN 113397991 A CN113397991 A CN 113397991A
- Authority
- CN
- China
- Prior art keywords
- spinning
- whitening
- water
- moisturizing
- essence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000007787 solid Substances 0.000 title claims abstract description 48
- 230000002087 whitening effect Effects 0.000 title claims abstract description 43
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- 238000002360 preparation method Methods 0.000 title claims abstract description 35
- 102000008186 Collagen Human genes 0.000 claims abstract description 49
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- 230000001815 facial effect Effects 0.000 claims abstract description 29
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 46
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- VDZOOKBUILJEDG-UHFFFAOYSA-M tetrabutylammonium hydroxide Chemical compound [OH-].CCCC[N+](CCCC)(CCCC)CCCC VDZOOKBUILJEDG-UHFFFAOYSA-M 0.000 claims description 12
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- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 claims description 6
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- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 claims description 5
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 claims description 5
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- 235000019983 sodium metaphosphate Nutrition 0.000 claims description 5
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 4
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- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 20
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- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0069—Electro-spinning characterised by the electro-spinning apparatus characterised by the spinning section, e.g. capillary tube, protrusion or pin
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
- D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
- D04H1/728—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Textile Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Mechanical Engineering (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a whitening, moisturizing and water-locking solid essence facial mask and a preparation method thereof. The whitening and moisturizing effect of the prepared solid mask is further enhanced through the synergistic effect of the collagen with the effects of natural moisturizing, wrinkle prevention, whitening, freckle removal and the like and the nicotinamide with the effects of whitening, freckle removal, aging resistance, wrinkle removal, cutin removal, moisturizing and the like; the nanofiber obtained by electrostatic spinning has fine particle size, can promote effective whitening and moisturizing ingredients such as collagen and nicotinamide to be fully absorbed by skin, and greatly improves the using effect of essence in the mask; and the antibacterial property of the antibacterial peptide endows the mask with stronger antibacterial property, and has good effects of resisting bacteria and diminishing inflammation of the skin.
Description
Technical Field
The invention relates to the technical field of facial masks, and particularly relates to a whitening, moisturizing and water-locking solid-state essence facial mask and a preparation method thereof.
Background
With the improvement of living standard and the development of facial mask preparation technology, more and more types and functions of facial masks appear in the public visual field, the facial masks are various in types and diversified in combination, and the facial masks with whitening and moisturizing effects are one of the facial masks. The skin color of a human body is determined by three major factors: 1. melanin, carotene, and other pigment content in the skin; 2. the thickness of the skin and the phenomenon of light scattering of natural light at the skin surface; 3. the oxygen and hemoglobin content in the blood in the capillaries of the dermal layer of the skin. Melanin is a product of melanocyte metabolism, and gradually deposits in the stratum corneum of the skin, thereby affecting the color of the skin. It is known that the pathway of whitening the human body is mainly achieved by inhibiting the formation of melanin. Moisturizing is achieved by reducing the evaporation of skin moisture and locking the moisture through some substances.
The collagen is a moisturizing factor and has the effect of inhibiting tyrosine in the skin from being converted into melanin, so that the collagen has the effects of purely natural moisturizing, whitening, wrinkle resistance, freckle removal and the like. The niacinamide has the best effect of whitening, can inhibit the generation and transfer of melanin, lighten color spots, accelerate skin metabolism, accelerate the shedding of a cutin barrier layer and remove the melanin on the surface, thereby achieving the whitening effect. Meanwhile, the niacinamide can also enhance the moisturizing and water-locking effects of other moisturizing components, improve the water content of the skin, regulate the water-oil balance of the skin, and relieve the dryness and darkness of the skin.
At present, most whitening and moisturizing facial masks are still applied after the essence is soaked in non-woven fabrics, the problems of essence waste, difficulty in long-term storage, environmental pollution caused by discarding after use and the like exist in the method, and the problems of the existing facial masks are urgently needed to be solved. Therefore, the whitening, moisturizing and water-locking solid essence mask and the preparation method thereof are provided.
Disclosure of Invention
The invention aims to provide a whitening, moisturizing and water-locking solid essence mask and a preparation method thereof, and aims to solve the problems in the background technology.
In order to solve the technical problems, the invention provides the following technical scheme: the utility model provides a whitening moisture retention water-locking solid-state essence facial mask, is including collecting substrate layer and essence nanofiber layer, it is the ITO film to collect the substrate layer, essence nanofiber layer is prepared by solution electrostatic spinning.
Further, the essence nanofiber layer comprises a first component, a second component, purified water and auxiliary materials;
the first component is one or more of human-like collagen, nicotinamide and ginseng extract;
the second component is one or more of polyvinyl alcohol, G-type brown algae oligosaccharide, hyaluronic acid, arginine/lysine polypeptide, antibacterial peptide, chitosan and mussel mucin;
the auxiliary materials are one or more of glycerol, alcohols, mineral oil, an antioxidant, a surfactant and a preservative.
Further, the essence nanofiber layer comprises the following components: human-like collagen, nicotinamide, ginseng extract, polyvinyl alcohol, G-type alginate oligosaccharide, hyaluronic acid, arginine/lysine polypeptide, antibacterial peptide, chitosan, mussel mucin, purified water and glycerol.
Further, the essence nanofiber layer comprises the following components: human-like collagen, arginine/lysine polypeptide, hyaluronic acid, mussel mucin, chitosan, antioxidant and purified water.
Further, the essence nanofiber layer comprises the following components: hyaluronic acid, nicotinamide, antibacterial peptide, arginine/lysine polypeptide, G-type brown algae oligosaccharide, purified water and glycerol.
Further, the essence nanofiber layer comprises the following components: hyaluronic acid, ginseng extract, arginine/lysine polypeptide, antibacterial peptide, polyvinyl alcohol, antioxidant and purified water.
A preparation method of a whitening, moisturizing and water-locking solid essence facial mask.
Further, the method comprises the following steps:
(1) preparation of spinning solution A:
sequentially adding human-like collagen, arginine/lysine polypeptide, antibacterial peptide, mussel mucin and hyaluronic acid into purified water, and stirring at room temperature of 25 ℃ until the collagen, arginine/lysine polypeptide, antibacterial peptide, mussel mucin and hyaluronic acid are completely dissolved to prepare spinning solution A;
(2) preparation of spinning solution B:
sequentially adding polyvinyl alcohol, G-type alginate oligosaccharide and chitosan into purified water, heating to 90 ℃, stirring until the materials are uniformly dissolved, standing and cooling to room temperature, adding nicotinamide and glycerol, stirring at room temperature until the solutions are uniformly mixed, adding a ginseng extract, stirring at room temperature until the solutions are uniform, standing, and preparing a spinning solution B;
(3) preparing a spinning mixed solution:
uniformly mixing the spinning solution A and the spinning solution B, stirring for 15min, standing, and defoaming to obtain a spinning mixed solution for later use;
(4) electrostatic spinning:
and (3) taking the ITO film as a collecting base material layer, and carrying out electrostatic spinning on the spinning mixed solution to obtain an essence nanofiber layer so as to obtain the solid facial mask.
Further, the electrostatic spinning process comprises the following steps: the spinning distance is 12-17 cm, the injection speed is 1.2-1.5 mL/h, the spinning voltage is 13.50-15.50 kV, and the needle type is 0.7-0.9 mm.
Further, the spinning solution A comprises the following components in concentration: 2.5-6% of human-like collagen, 2-3% of arginine/lysine polypeptide, 0.4-0.8% of antibacterial peptide, 3-5% of hyaluronic acid and 2-3% of mussel mucin.
Further, the spinning solution B comprises the following components in concentration: 3-6% of polyvinyl alcohol, 0.5-1.5% of brown algae oligosaccharide G, 2-5% of nicotinamide, 0.2-0.8% of ginseng extract, 2-3% of chitosan and 0.01-0.10% of glycerol.
Furthermore, the mass ratio of the spinning solution A to the spinning solution B in the spinning mixed solution is (1-3) to (3-6).
Further, the step (1) comprises the following processes:
dissolving glutathione in water, wherein the system temperature is 0-2 ℃, adding sodium metaphosphate, adjusting the system pH to 6.5-7.0 to prepare a buffer solution, adding evening primrose oil, mixing, emulsifying and homogenizing at 8000-10000 rpm for 1-2 min to prepare an emulsion;
dissolving hydrolyzed hyaluronic acid in water, adding tetrabutyl ammonium hydroxide solution for reaction, cleaning and drying to obtain a product A;
adding a catalyst N, N-dicyclohexyl carbodiimide into polylactic acid and N-hydroxysuccinimide, reacting for 24 hours in a nitrogen atmosphere, cleaning and drying to obtain a product B;
mixing ethyl acetate and ethanol to dissolve a product B, slowly adding the product A and diethylamine, reacting for 24 hours at the temperature of 40-48 ℃ in a nitrogen atmosphere, cleaning and drying; adding the mixture into a mixed solution of ethyl acetate and ethanol, stirring and dissolving, adding the mixture into the emulsion, carrying out ultrasonic oscillation for 5-10 min, and stirring for 24h to obtain modified particles;
sequentially adding human-like collagen, arginine/lysine polypeptide, antibacterial peptide, mussel mucin and modified particles into purified water, stirring at room temperature of 25 ℃ until the modified particles are completely dissolved, and preparing into spinning solution A.
Compared with the prior art, the invention has the following beneficial effects:
1. according to the whitening, moisturizing and water-locking solid-state essence facial mask and the preparation method thereof, the whitening and moisturizing effects of the prepared solid-state facial mask are further enhanced through the synergistic effect of the collagen with the effects of natural moisturizing, wrinkle prevention, whitening, freckle removal and the like and the nicotinamide with the effects of whitening, freckle removal, aging resistance, wrinkle removal, cutin removal, moisturizing and the like; the nanofiber obtained by electrostatic spinning has fine particle size, can promote effective whitening and moisturizing ingredients such as collagen and nicotinamide to be fully absorbed by skin, and greatly improves the using effect of essence in the mask; and the antibacterial property of the antibacterial peptide endows the mask with stronger antibacterial property, and has good effects of resisting bacteria and diminishing inflammation of the skin.
2. According to the whitening, moisturizing and water-locking solid-state essence mask and the preparation method thereof, the solid-state mask prepared by electrostatic spinning gets rid of the combination mode of the base cloth and the essence of the traditional mask, but the base cloth is integrated with the essence, the base cloth is the essence, and the essence is the combination mode of the base cloth, so that the waste of the essence and the pollution of the waste base cloth to the environment are greatly reduced; and the product obtained by the invention is a solid facial mask, so the preservation time of the facial mask can be further prolonged.
3. According to the whitening, moisturizing and water-locking solid essence mask and the preparation method thereof, polylactic acid and hydrolyzed hyaluronic acid are grafted through tetrabutylammonium hydroxide and N-hydroxysuccinimide to form amphoteric chemicals with skin care effects; the glutathione and the evening primrose oil are homogenized in water to obtain emulsion, and when the glutathione and the evening primrose oil are in the same aqueous system, the emulsion can be wrapped by the microemulsion formed by the amphoteric chemicals; when the spinning solution A is prepared, the spinning solution A can interact with protein components such as human-like collagen, arginine/lysine polypeptide, mussel mucin and the like, the polyelectrolyte characteristics of the components are reduced, so that the conductivity of the spinning solution A is reduced, the processability in electrostatic spinning is improved, and the nanofiber with no defects and better mechanical property can be obtained; and the glutathione and the evening primrose oil are coated, so that the prepared solid mask is slowly released when in use, the stimulation of the components to the skin can be relieved, and the experimental effect of the mask is improved.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
(1) Preparation of spinning solution A:
sequentially adding human-like collagen, arginine/lysine polypeptide, antibacterial peptide, mussel mucin and hyaluronic acid into purified water, and stirring at room temperature of 25 ℃ until the collagen, arginine/lysine polypeptide, antibacterial peptide, mussel mucin and hyaluronic acid are completely dissolved to prepare spinning solution A;
wherein the concentration of each component in the spinning solution A is as follows: 3% of human-like collagen, 2% of arginine/lysine polypeptide, 0.5% of antibacterial peptide, 3% of hyaluronic acid and 2.5% of mussel mucin;
(2) preparation of spinning solution B:
sequentially adding polyvinyl alcohol, G-type alginate oligosaccharide and chitosan into purified water, heating to 90 ℃, stirring until the materials are uniformly dissolved, standing and cooling to room temperature, adding nicotinamide and glycerol, stirring at room temperature until the solutions are uniformly mixed, adding a ginseng extract, stirring at room temperature until the solutions are uniform, standing, and preparing a spinning solution B;
wherein the concentration of each component in the spinning solution B is as follows: 6% of polyvinyl alcohol, 1% of G-type alginate oligosaccharide, 2.5% of nicotinamide, 0.4% of ginseng extract, 2.5% of chitosan and 0.05% of glycerol;
(3) preparing a spinning mixed solution:
uniformly mixing the spinning solution A and the spinning solution B according to the mass ratio of 2:3, stirring for 15min, standing, and defoaming to obtain a spinning mixed solution for later use;
(4) electrostatic spinning:
the ITO film is used as a collecting substrate layer, spinning mixed liquid is taken to carry out electrostatic spinning on the ITO film, and the electrostatic spinning process comprises the following steps: spinning distance of 13cm, injection speed of 1.2mL/h, spinning voltage of 15.00kV, and needle size of 0.9mm to obtain essence nanofiber layer, and making into solid facial mask.
Example 2
The concentrations of the components in the spinning solution A are as follows: 4% of human-like collagen, 2% of arginine/lysine polypeptide, 0.5% of antibacterial peptide, 3% of hyaluronic acid and 2.5% of mussel mucin;
the concentrations of the components in the spinning solution B are as follows: 6% of polyvinyl alcohol, 1% of G-type alginate oligosaccharide, 3% of nicotinamide, 0.4% of ginseng extract, 2.5% of chitosan and 0.05% of glycerol;
the mass ratio of the spinning solution A to the spinning solution B in the spinning mixed solution is 3: 3;
the electrostatic spinning process comprises the following steps: the spinning distance is 13cm, the injection speed is 1.4mL/h, the spinning voltage is 15.00kV, and the needle type is 0.9 mm;
the other steps and processes were the same as in example 1 to obtain a solid mask.
Example 3
The concentrations of the components in the spinning solution A are as follows: 5% of human-like collagen, 2% of arginine/lysine polypeptide, 0.5% of antibacterial peptide, 3% of hyaluronic acid and 2.5% of mussel mucin;
the concentrations of the components in the spinning solution B are as follows: 6% of polyvinyl alcohol, 1.5% of G-type brown algae oligosaccharide, 3.5% of nicotinamide, 0.4% of ginseng extract, 2.5% of chitosan and 0.05% of glycerol;
the mass ratio of the spinning solution A to the spinning solution B in the spinning mixed solution is 3: 3;
the electrostatic spinning process comprises the following steps: the spinning distance is 13cm, the injection speed is 1.3mL/h, the spinning voltage is 15.50kV, and the needle type is 0.9 mm;
the other steps and processes were the same as in example 1 to obtain a solid mask.
Example 4
The concentrations of the components in the spinning solution A are as follows: 3% of human-like collagen, 2.5% of arginine/lysine polypeptide, 0.6% of antibacterial peptide, 3% of hyaluronic acid and 2.5% of mussel mucin;
the concentrations of the components in the spinning solution B are as follows: 5% of polyvinyl alcohol, 1% of G-type alginate oligosaccharide, 3% of nicotinamide, 0.5% of ginseng extract, 2.5% of chitosan and 0.05% of glycerol;
the mass ratio of the spinning solution A to the spinning solution B in the spinning mixed solution is 2: 3;
the electrostatic spinning process comprises the following steps: the spinning distance is 14cm, the injection speed is 1.2mL/h, the spinning voltage is 15.00kV, and the needle type is 0.8 mm;
the other steps and processes were the same as in example 1 to obtain a solid mask.
Example 5
The concentrations of the components in the spinning solution A are as follows: 4% of human-like collagen, 2.5% of arginine/lysine polypeptide, 0.6% of antibacterial peptide, 3% of hyaluronic acid and 2.5% of mussel mucin;
the concentrations of the components in the spinning solution B are as follows: 5% of polyvinyl alcohol, 1% of G-type alginate oligosaccharide, 3.5% of nicotinamide, 0.5% of ginseng extract, 2.5% of chitosan and 0.05% of glycerol;
the mass ratio of the spinning solution A to the spinning solution B in the spinning mixed solution is 3: 3;
the electrostatic spinning process comprises the following steps: the spinning distance is 14cm, the injection speed is 1.3mL/h, the spinning voltage is 15.00kV, and the needle type is 0.8 mm;
the other steps and processes were the same as in example 1 to obtain a solid mask.
Example 6
The concentrations of the components in the spinning solution A are as follows: 5% of human-like collagen, 2.5% of arginine/lysine polypeptide, 0.6% of antibacterial peptide, 3% of hyaluronic acid and 2.5% of mussel mucin;
the concentrations of the components in the spinning solution B are as follows: 5% of polyvinyl alcohol, 1.5% of G-type brown algae oligosaccharide, 4% of nicotinamide, 0.5% of ginseng extract, 2.5% of chitosan and 0.05% of glycerol;
the mass ratio of the spinning solution A to the spinning solution B in the spinning mixed solution is 3: 3;
the electrostatic spinning process comprises the following steps: the spinning distance is 14cm, the injection speed is 1.4mL/h, the spinning voltage is 15.50kV, and the needle type is 0.8 mm;
the other steps and processes were the same as in example 1 to obtain a solid mask.
Example 7
The concentrations of the components in the spinning solution A are as follows: 4% of human-like collagen, 3% of arginine/lysine polypeptide, 0.6% of antibacterial peptide, 4% of hyaluronic acid and 3% of mussel mucin;
the concentrations of the components in the spinning solution B are as follows: 4% of polyvinyl alcohol, 1% of G-type alginate oligosaccharide, 4.5% of nicotinamide, 0.6% of ginseng extract, 2.5% of chitosan and 0.05% of glycerol;
the mass ratio of the spinning solution A to the spinning solution B in the spinning mixed solution is 2: 3;
the electrostatic spinning process comprises the following steps: the spinning distance is 15cm, the injection speed is 1.3mL/h, the spinning voltage is 15.00kV, and the needle type is 0.9 mm;
the other steps and processes were the same as in example 1 to obtain a solid mask.
Example 8
The concentrations of the components in the spinning solution A are as follows: 5% of human-like collagen, 3% of arginine/lysine polypeptide, 0.6% of antibacterial peptide, 4% of hyaluronic acid and 3% of mussel mucin;
the concentrations of the components in the spinning solution B are as follows: 4% of polyvinyl alcohol, 1.5% of brown algae oligosaccharide G, 4.5% of nicotinamide, 0.6% of ginseng extract, 2.5% of chitosan and 0.05% of glycerol;
the mass ratio of the spinning solution A to the spinning solution B in the spinning mixed solution is 2: 3;
the electrostatic spinning process comprises the following steps: the spinning distance is 15cm, the injection speed is 1.5mL/h, the spinning voltage is 15.50kV, and the needle type is 0.9 mm;
the other steps and processes were the same as in example 1 to obtain a solid mask.
Example 9
(1) Preparation of spinning solution A:
sequentially adding human-like collagen, arginine/lysine polypeptide, mussel mucin and hyaluronic acid into purified water, stirring at room temperature of 25 ℃ until the collagen, the arginine/lysine polypeptide, the mussel mucin and the hyaluronic acid are completely dissolved, and preparing a spinning solution A;
wherein the concentration of each component in the spinning solution A is as follows: 3% human-like collagen, 2% arginine/lysine polypeptide, 3% hyaluronic acid, 2.5% mussel mucin;
(2) preparation of spinning solution B:
adding chitosan into purified water, heating to 90 ℃, stirring until the chitosan is dissolved uniformly, standing and cooling to room temperature, adding an antioxidant, stirring at room temperature until the solution is homogeneous, standing, and preparing into a spinning solution B; the spinning solution B contains 2.5% of chitosan and 0.01% of antioxidant;
(3) preparing a spinning mixed solution:
uniformly mixing the spinning solution A and the spinning solution B according to the mass ratio of 2:3, stirring for 15min, standing, and defoaming to obtain a spinning mixed solution for later use;
(4) electrostatic spinning:
the ITO film is used as a collecting substrate layer, spinning mixed liquid is taken to carry out electrostatic spinning on the ITO film, and the electrostatic spinning process comprises the following steps: spinning distance of 13cm, injection speed of 1.2mL/h, spinning voltage of 15.00kV, and needle size of 0.9mm to obtain essence nanofiber layer, and making into solid facial mask.
Example 10
(1) Preparation of spinning solution A:
sequentially adding arginine/lysine polypeptide, antibacterial peptide and hyaluronic acid into purified water, and stirring at room temperature of 25 ℃ until the arginine/lysine polypeptide, the antibacterial peptide and the hyaluronic acid are completely dissolved to prepare spinning solution A;
wherein the concentration of each component in the spinning solution A is as follows: 2% arginine/lysine polypeptide, 0.5% antibacterial peptide, 3% hyaluronic acid;
(2) preparation of spinning solution B:
adding the G-type brown algae oligosaccharide into purified water, heating to 90 ℃, stirring until the G-type brown algae oligosaccharide is dissolved uniformly, standing and cooling to room temperature, adding nicotinamide and glycerol, stirring at room temperature until the solution is mixed uniformly, adding glycerol, stirring at room temperature until the solution is homogeneous, standing, and preparing into a spinning solution B;
wherein the concentration of each component in the spinning solution B is as follows: 1% brown algae oligosaccharide type G, 2.5 nicotinamide and 0.05% glycerol;
(3) preparing a spinning mixed solution:
uniformly mixing the spinning solution A and the spinning solution B according to the mass ratio of 2:3, stirring for 15min, standing, and defoaming to obtain a spinning mixed solution for later use;
(4) electrostatic spinning:
the ITO film is used as a collecting substrate layer, spinning mixed liquid is taken to carry out electrostatic spinning on the ITO film, and the electrostatic spinning process comprises the following steps: spinning distance of 13cm, injection speed of 1.2mL/h, spinning voltage of 15.00kV, and needle size of 0.9mm to obtain essence nanofiber layer, and making into solid facial mask.
Example 11
(1) Preparation of spinning solution A:
sequentially adding arginine/lysine polypeptide, antibacterial peptide and hyaluronic acid into purified water, and stirring at room temperature of 25 ℃ until the arginine/lysine polypeptide, the antibacterial peptide and the hyaluronic acid are completely dissolved to prepare spinning solution A;
wherein the concentration of each component in the spinning solution A is as follows: 2% arginine/lysine polypeptide, 0.5% antibacterial peptide, 3% hyaluronic acid;
(2) preparation of spinning solution B:
adding polyvinyl alcohol into purified water, heating to 90 ℃, stirring until the polyvinyl alcohol is dissolved uniformly, standing and cooling to room temperature, adding a ginseng extract, stirring at room temperature until the solution is mixed uniformly, adding an antioxidant, stirring at room temperature until the solution is homogeneous, standing, and preparing into a spinning solution B;
wherein the concentration of each component in the spinning solution B is as follows: 6% of polyvinyl alcohol, 0.4% of ginseng extract and 0.01% of antioxidant;
(3) preparing a spinning mixed solution:
uniformly mixing the spinning solution A and the spinning solution B according to the mass ratio of 2:3, stirring for 15min, standing, and defoaming to obtain a spinning mixed solution for later use;
(4) electrostatic spinning:
the ITO film is used as a collecting substrate layer, spinning mixed liquid is taken to carry out electrostatic spinning on the ITO film, and the electrostatic spinning process comprises the following steps: spinning distance of 13cm, injection speed of 1.2mL/h, spinning voltage of 15.00kV, and needle size of 0.9mm to obtain essence nanofiber layer, and making into solid facial mask.
Example 12
(1) Preparation of spinning solution A:
dissolving glutathione in water at a system temperature of 2 deg.C, adding sodium metaphosphate, adjusting system pH to 7.0 to obtain buffer solution, adding oleum Oenotherae Erythrosepalae, mixing, emulsifying and homogenizing at 8000rpm for 1min to obtain emulsion;
dissolving hydrolyzed hyaluronic acid in water, adding tetrabutyl ammonium hydroxide solution for reaction, cleaning and drying to obtain a product A;
adding a catalyst N, N-dicyclohexyl carbodiimide into polylactic acid and N-hydroxysuccinimide, reacting for 24 hours in a nitrogen atmosphere, cleaning and drying to obtain a product B;
mixing ethyl acetate and ethanol to dissolve the product B, slowly adding the product A and diethylamine, reacting at 40 ℃ in a nitrogen atmosphere for 24h, cleaning and drying; adding into mixed solution of ethyl acetate and ethanol, stirring for dissolving, adding into emulsion, ultrasonic oscillating for 5min, stirring for 24 hr to obtain modified particles;
sequentially adding human-like collagen, arginine/lysine polypeptide, antibacterial peptide, mussel mucin and modified particles into purified water, and stirring at room temperature of 25 ℃ until the collagen, arginine/lysine polypeptide, antibacterial peptide, mussel mucin and modified particles are completely dissolved to prepare spinning solution A;
the concentrations of the components in the spinning solution A are as follows: 5% of human-like collagen, 3% of arginine/lysine polypeptide, 0.6% of antibacterial peptide, 3% of modified particles and 3% of mussel mucin;
the other steps and processes were the same as in example 1 to obtain a solid mask.
Example 13
(1) Preparation of spinning solution A:
dissolving glutathione in water at system temperature of 0 deg.C, adding sodium metaphosphate, adjusting system pH to 6.5 to obtain buffer solution, adding oleum Oenotherae Erythrosepalae, mixing, emulsifying and homogenizing at 10000rpm for 2min to obtain emulsion;
dissolving hydrolyzed hyaluronic acid in water, adding tetrabutyl ammonium hydroxide solution for reaction, cleaning and drying to obtain a product A;
adding a catalyst N, N-dicyclohexyl carbodiimide into polylactic acid and N-hydroxysuccinimide, reacting for 24 hours in a nitrogen atmosphere, cleaning and drying to obtain a product B;
mixing ethyl acetate and ethanol to dissolve the product B, slowly adding the product A and diethylamine, reacting at 45 ℃ in a nitrogen atmosphere for 24h, cleaning and drying; adding into mixed solution of ethyl acetate and ethanol, stirring for dissolving, adding into emulsion, ultrasonic oscillating for 7min, stirring for 24 hr to obtain modified particles;
sequentially adding human-like collagen, arginine/lysine polypeptide, antibacterial peptide, mussel mucin and modified particles into purified water, and stirring at room temperature of 25 ℃ until the collagen, arginine/lysine polypeptide, antibacterial peptide, mussel mucin and modified particles are completely dissolved to prepare spinning solution A;
the concentrations of the components in the spinning solution A are as follows: 5% of human-like collagen, 3% of arginine/lysine polypeptide, 0.6% of antibacterial peptide, 5% of modified particles and 3% of mussel mucin;
the other steps and processes were the same as in example 1 to obtain a solid mask.
Comparative example 1
(1) Preparation of solution A:
sequentially adding human-like collagen, arginine/lysine polypeptide, antibacterial peptide, mussel mucin and hyaluronic acid into purified water, and stirring at room temperature of 25 ℃ until the collagen, arginine/lysine polypeptide, antibacterial peptide, mussel mucin and hyaluronic acid are completely dissolved to prepare solution A;
wherein the concentration of each component in the spinning solution A is as follows: 3% of human-like collagen, 2% of arginine/lysine polypeptide, 0.5% of antibacterial peptide, 3% of hyaluronic acid and 2.5% of mussel mucin;
(2) preparation of solution B:
sequentially adding polyvinyl alcohol, G-type alginate oligosaccharide and chitosan into purified water, heating to 90 ℃, stirring until the materials are uniformly dissolved, standing and cooling to room temperature, adding nicotinamide and glycerol, stirring at room temperature until the solutions are uniformly mixed, adding the ginseng extract, stirring at room temperature until the solutions are uniform, and standing to prepare a solution B;
wherein the concentration of each component in the spinning solution B is as follows: 6% of polyvinyl alcohol, 1% of G-type alginate oligosaccharide, 2.5% of nicotinamide, 0.4% of ginseng extract and 2.5% of chitosan;
(3) preparation of mixed solution:
uniformly mixing the spinning solution A and the spinning solution B according to the mass ratio of 2:3, stirring for 15min, standing, and defoaming to obtain a mixed solution for later use;
(4) preparing a facial mask:
and (3) soaking the non-woven fabric in the spinning mixed solution to obtain the facial mask.
Comparative example 2
(1) Preparation of spinning solution A:
dissolving glutathione in water at system temperature of 0 deg.C, adding sodium metaphosphate, adjusting system pH to 6.5 to obtain buffer solution, adding oleum Oenotherae Erythrosepalae, mixing, emulsifying and homogenizing at 10000rpm for 2min to obtain emulsion;
adding hydrolyzed hyaluronic acid and polylactic acid into the emulsion, ultrasonically oscillating for 7min, and stirring for 24h to obtain modified particles;
sequentially adding human-like collagen, arginine/lysine polypeptide, antibacterial peptide, mussel mucin and modified particles into purified water, and stirring at room temperature of 25 ℃ until the collagen, arginine/lysine polypeptide, antibacterial peptide, mussel mucin and modified particles are completely dissolved to prepare spinning solution A;
the concentrations of the components in the spinning solution A are as follows: 5% of human-like collagen, 3% of arginine/lysine polypeptide, 0.6% of antibacterial peptide, 5% of modified particles and 3% of mussel mucin;
the other steps and processes were the same as in example 1 to obtain a solid mask.
Comparative example 3
(1) Preparation of spinning solution A:
dissolving hydrolyzed hyaluronic acid in water, adding tetrabutyl ammonium hydroxide solution for reaction, cleaning and drying to obtain a product A;
adding a catalyst N, N-dicyclohexyl carbodiimide into polylactic acid and N-hydroxysuccinimide, reacting for 24 hours in a nitrogen atmosphere, cleaning and drying to obtain a product B;
mixing ethyl acetate and ethanol to dissolve the product B, slowly adding the product A and diethylamine, reacting at 45 ℃ in a nitrogen atmosphere for 24h, cleaning and drying; adding into mixed solution of ethyl acetate and ethanol, stirring for dissolving, adding glutathione and oleum Oenotherae Erythrosepalae, ultrasonic oscillating for 7min, and stirring for 24 hr to obtain modified particles;
sequentially adding human-like collagen, arginine/lysine polypeptide, antibacterial peptide, mussel mucin and modified particles into purified water, and stirring at room temperature of 25 ℃ until the collagen, arginine/lysine polypeptide, antibacterial peptide, mussel mucin and modified particles are completely dissolved to prepare spinning solution A;
the concentrations of the components in the spinning solution A are as follows: 5% of human-like collagen, 3% of arginine/lysine polypeptide, 0.6% of antibacterial peptide, 5% of modified particles and 3% of mussel mucin;
the other steps and processes were the same as in example 1 to obtain a solid mask.
Experiment of
Samples were prepared from the solid masks obtained in examples 1 to 13 and comparative examples 1 to 3, and their properties were measured and recorded:
(1) safety tests:
a. and (3) stability testing: placing the sample in a centrifuge, rotating at 3000rpm for 30min, and removing the separation and delamination conditions of the observed facial mask sample;
b. skin irritation test: selecting 2cm × 2cm skin on two sides of spinal column of mouse, shearing with scissors, removing hair with 8% sodium sulfide, scraping, washing with distilled water, applying sample and spraying distilled water, covering with two layers of gauze and one layer of cellophane, fixing with non-irritant adhesive plaster and bandage, and using right skin as control group. After the experiment for 8h, washing and wiping the skin by warm water, and observing skin reaction;
c. acute oral toxicity test: taking healthy adult mice adapted to 7d in experimental environment, carrying out half-and-half fasting for 14h, providing distilled water during the fasting period, taking samples, carrying out disposable perfusion by using a gastric perfusion needle, and observing the poisoning and death conditions in the mice 7 d.
(2) And (3) testing mechanical properties:
cutting a sample to obtain a parallel sample of 100cm multiplied by 10cm, balancing for 24h in a constant temperature and humidity environment (20 ℃, the humidity is 65%), testing the mechanical property by adopting an SANA electronic universal tester, clamping the distance to be 28mm to obtain a stress-strain curve, and calculating the elongation at break of the sample.
(3) And (4) moisture retention performance test:
exposing the skin area to be detected in the air at room temperature of 20 deg.C and relative humidity of 55% for 10min, and detecting the water content of the skin at the moment, and recording as C1; respectively applying a test sample (20cm multiplied by 20cm) on a skin area to be detected, spraying distilled water, tapping until the liquid formed by the test sample when meeting water is completely absorbed by the skin (the facial mask in the comparative example 1 does not need to spray distilled water), and detecting the water content of the skin in the area at the moment, wherein the water content is recorded as C2; calculating the increase of C2 compared with C1, and recording as the increase of skin moisture;
and spraying distilled water on the adjacent area of the skin area to be detected and tapping, detecting the skin water content of the area at the moment, using the area as a control group, and calculating the skin water content increase.
(4) And (3) testing the whitening performance:
exposing the skin area to be detected in the air for 30min at room temperature of 20 deg.C and relative humidity of 55%, detecting at four corners and middle part of the skin area to be detected (20cm × 20cm) with melanin test probe, and calculating average melanin content as C3; applying the test sample every two days, detecting the melanin content of the area to be detected after 12 th application, and calculating the average melanin content which is marked as C4; calculating the reduction of the C4 compared with the C3, and marking as the reduction of the melanin;
from the data in the table above, it is clear that the following conclusions can be drawn:
the masks obtained in examples 1 to 13 were compared with those obtained in comparative examples 1 to 3, and the results of the tests were found to be:
safety experiments show that a. stability test: the obvious layering phenomenon appears in the comparative example 1, and other samples do not have obvious separation and layering phenomena, so that the character is stable; b. skin irritation test: in the comparative example 3, the test part of the white mouse has a red and swollen phenomenon, and the test parts of other white mice have no obvious skin reaction; c. acute oral toxicity test: no toxic or death.
1. Compared with comparative example 1, the skin moisture content of the facial masks obtained in examples 1 to 13 is increased remarkably, and the melanin reduction is reduced remarkably, so that the moisturizing performance and the whitening performance of the prepared solid facial mask are improved;
2. compared with example 1, the facial masks obtained in examples 12-13 have obviously improved elongation at break, elastic modulus and tensile strength, and improved skin moisture content and melanin reduction; the modified particles in the invention realize the improvement of the mechanical properties of the prepared solid mask, so that the prepared solid mask has fewer defects of nano fibers and better performance, and can promote the improvement of the moisturizing performance and the whitening performance of the prepared solid mask;
compared with the example 13, the hydrolyzed hyaluronic acid and the polylactic acid in the comparative example 2 are not grafted, and the glutathione and the evening primrose oil in the comparative example 3 are not emulsified; the experimental data are degraded, and the components of the modified particles and the preparation process thereof can promote the performance of the prepared solid mask.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Furthermore, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process method article or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process method article or apparatus.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement and improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The whitening, moisturizing and water-locking solid essence mask is characterized in that: the ITO film-containing essence liquid nanofiber layer is characterized by comprising a collecting base material layer and an essence liquid nanofiber layer, wherein the collecting base material layer is an ITO film, and the essence liquid nanofiber layer is prepared by solution electrostatic spinning.
2. The whitening, moisturizing and water-locking solid essence mask as claimed in claim 1, wherein the whitening, moisturizing and water-locking solid essence mask comprises: the essence nanofiber layer comprises a first component, a second component, purified water and auxiliary materials;
the first component is one or more of human-like collagen, nicotinamide and ginseng extract;
the second component is one or more of polyvinyl alcohol, G-type brown algae oligosaccharide, hyaluronic acid, arginine/lysine polypeptide, antibacterial peptide, chitosan and mussel mucin;
the auxiliary materials are one or more of glycerol, alcohols, mineral oil, an antioxidant, a surfactant and a preservative.
3. The whitening, moisturizing and water-locking solid essence mask as claimed in claim 2, wherein the whitening, moisturizing and water-locking solid essence mask comprises: the essence nanofiber layer comprises the following components: human-like collagen, nicotinamide, ginseng extract, polyvinyl alcohol, G-type alginate oligosaccharide, hyaluronic acid, arginine/lysine polypeptide, antibacterial peptide, chitosan, mussel mucin, purified water and glycerol.
4. The whitening, moisturizing and water-locking solid essence mask as claimed in claim 2, wherein the whitening, moisturizing and water-locking solid essence mask comprises: the essence nanofiber layer comprises the following components: human-like collagen, arginine/lysine polypeptide, hyaluronic acid, mussel mucin, chitosan, antioxidant and purified water.
5. The whitening, moisturizing and water-locking solid essence mask as claimed in claim 2, wherein the whitening, moisturizing and water-locking solid essence mask comprises: the essence nanofiber layer comprises the following components: hyaluronic acid, nicotinamide, antibacterial peptide, arginine/lysine polypeptide, G-type brown algae oligosaccharide, purified water and glycerol.
6. The whitening, moisturizing and water-locking solid essence mask as claimed in claim 2, wherein the whitening, moisturizing and water-locking solid essence mask comprises: the essence nanofiber layer comprises the following components: hyaluronic acid, ginseng extract, arginine/lysine polypeptide, antibacterial peptide, polyvinyl alcohol, antioxidant and purified water.
7. A preparation method of a whitening, moisturizing and water-locking solid essence mask is characterized by comprising the following steps: the method comprises the following steps:
(1) preparation of spinning solution A:
sequentially adding human-like collagen, arginine/lysine polypeptide, antibacterial peptide, mussel mucin and hyaluronic acid into purified water, and stirring at room temperature of 25 ℃ until the collagen, arginine/lysine polypeptide, antibacterial peptide, mussel mucin and hyaluronic acid are completely dissolved to prepare spinning solution A;
(2) preparation of spinning solution B:
sequentially adding polyvinyl alcohol, G-type alginate oligosaccharide and chitosan into purified water, heating to 90 ℃, stirring until the materials are uniformly dissolved, standing and cooling to room temperature, adding nicotinamide and glycerol, stirring at room temperature until the solutions are uniformly mixed, adding a ginseng extract, stirring at room temperature until the solutions are uniform, standing, and preparing a spinning solution B;
(3) preparing a spinning mixed solution:
uniformly mixing the spinning solution A and the spinning solution B, stirring for 15min, standing, and defoaming to obtain a spinning mixed solution for later use;
(4) electrostatic spinning:
and (3) taking the ITO film as a collecting base material layer, and carrying out electrostatic spinning on the spinning mixed solution to obtain an essence nanofiber layer so as to obtain the solid facial mask.
8. The preparation method of the whitening, moisturizing and water-locking solid essence mask according to claim 7, characterized by comprising the following steps: the electrostatic spinning process comprises the following steps: the spinning distance is 12-17 cm, the injection speed is 1.2-1.5 mL/h, the spinning voltage is 13.50-15.50 kV, and the needle type is 0.7-0.9 mm.
9. The preparation method of the whitening, moisturizing and water-locking solid essence mask according to claim 7, characterized by comprising the following steps: the spinning solution A comprises the following components in concentration: 2.5-6% of human-like collagen, 2-3% of arginine/lysine polypeptide, 0.4-0.8% of antibacterial peptide, 3-5% of hyaluronic acid and 2-3% of mussel mucin;
the spinning solution B comprises the following components in concentration: 3-6% of polyvinyl alcohol, 0.5-1.5% of brown algae oligosaccharide G, 2-5% of nicotinamide, 0.2-0.8% of ginseng extract, 2-3% of chitosan and 0.01-0.10% of glycerol;
the mass ratio of the spinning solution A to the spinning solution B in the spinning mixed solution is (1-3) to (3-6).
10. The preparation method of the whitening, moisturizing and water-locking solid essence mask according to claim 7, characterized by comprising the following steps: the step (1) comprises the following processes:
dissolving glutathione in water, wherein the system temperature is 0-2 ℃, adding sodium metaphosphate, adjusting the system pH to 6.5-7.0 to prepare a buffer solution, adding evening primrose oil, mixing, emulsifying and homogenizing at 8000-10000 rpm for 1-2 min to prepare an emulsion;
dissolving hydrolyzed hyaluronic acid in water, adding tetrabutyl ammonium hydroxide solution for reaction, cleaning and drying to obtain a product A;
adding a catalyst N, N-dicyclohexyl carbodiimide into polylactic acid and N-hydroxysuccinimide, reacting for 24 hours in a nitrogen atmosphere, cleaning and drying to obtain a product B;
mixing ethyl acetate and ethanol to dissolve a product B, slowly adding the product A and diethylamine, reacting for 24 hours at the temperature of 40-48 ℃ in a nitrogen atmosphere, cleaning and drying; adding the mixture into a mixed solution of ethyl acetate and ethanol, stirring and dissolving, adding the mixture into the emulsion, carrying out ultrasonic oscillation for 5-10 min, and stirring for 24h to obtain modified particles;
sequentially adding human-like collagen, arginine/lysine polypeptide, antibacterial peptide, mussel mucin and modified particles into purified water, stirring at room temperature of 25 ℃ until the modified particles are completely dissolved, and preparing into spinning solution A.
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