CN113375957A - Sampling device - Google Patents

Abstract

The invention discloses a sampler, which comprises a shell and a sampling needle, wherein the shell comprises a containing cavity and a needle cavity, the side wall of the bottom of the needle cavity is provided with a liquid outlet, the containing cavity is communicated with the needle cavity through the liquid outlet, test paper is arranged in the containing cavity, the sampling needle comprises a needle head and a needle cylinder, the inner cavity of the needle cylinder is a liquid storage cavity for storing reagent liquid, the top of the liquid storage cavity is sealed through a sealing plug, the bottom of the liquid storage cavity is provided with a fragile structure, the needle cylinder is inserted into the needle cavity, the needle head is abutted against the bottom of the needle cavity and damages the fragile structure, the reagent liquid in the liquid storage cavity flows into the containing cavity through the damaged part of the fragile structure, and the reagent liquid is contacted with the test paper. The invention has the beneficial effects that: the sampler is ingenious in structural design, and after the sampler is assembled, the sampler is in a fully-sealed state, so that the problems of leakage, pollution and the like of a reagent sample are not needed to be worried, the sampler can be popularized globally, the global mortality of intestinal cancer can be effectively reduced, the intestinal cancer and gastric cancer screening can be completed at home, and the social significance is great.

Description

Sampling device

Technical Field

The invention relates to intestinal cancer and gastric cancer screening, in particular to a sampler.

Background

In the conventional fecal occult blood detection, the excrement and urine of a subject needs to be taken for inspection and detected by professional personnel in a hospital. However, due to the high requirements for specimen preservation and transportation in stool collection and handling, the hospital participants often ignore or do not have the sense of convenience to not check the stool. The excrement inspection is the item with the highest abandon inspection rate in China and the whole world. However, fecal sample detection is the first recommended method commonly recognized by the world health organization, american society of oncology, and experts in china for intestinal cancer screening, and the specificity of fecal sample detection for intestinal cancer is close to 80% at present, while the specificity of blood detection for intestinal cancer is only about 30%.

At present, no instrument suitable for the fecal occult blood self-test exists in the market, and some immune gold-labeled fecal occult blood reagent manufacturers design respective excrement collectors, but the excrement collectors do not have sampling amount control devices and do not comprise detectors, and all detections need to open fecal liquid. At present, fecal occult blood is only carried out in professional medical institutions, and when a professional detects the fecal occult blood, feces is firstly placed in a container with a buffer solution to be dissolved, then the feces solution in the container is poured into a small cup or a small hole, and then a liquid absorption test strip is inserted into the small cup or the small hole to detect the fecal occult blood.

The current hospital excrement detection process comprises the steps of enabling a physical examiner to go to a clinical laboratory to get an excrement sampling cup, go to a toilet to collect excrement into the excrement cup, transporting the excrement into the clinical laboratory, enabling the clinical examiner to collect the excrement into a diluent to be uniformly mixed, discarding redundant excrement, opening a reagent package to take out a reagent, sucking the uniformly mixed sample by a straw, adding the sample on a reagent sample pad, and judging the result within 5-10 minutes. Excrement and liquid are open in detection, the frequency of direct vision of the excrement is high, the excrement is easy to overturn and overflow during operation, hundreds of bacteria in the excrement are easy to cause pollution, and the excrement is discarded after being used, so that secondary pollution is easy to cause.

After the feces are subjected to routine inspection and specimen collection, the inspection is finished within 1-2 hours, otherwise, the cell components in the feces can be destroyed and decomposed due to the influence of pH, digestive enzyme and the like. The excrement sample can not be collected at any time like a blood sample, so that the uncertainty of the time for a physical examiner to transport to a place needing physical examination after collecting the excrement sample from home and the time for whether the physical examiner can detect the excrement sample immediately in a clinical laboratory is also the main reason of abandoning the physical examination. The problems of unsanitary excrement transportation, time delay, embarrassment and the like are also the main reasons for abandoning the excrement.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provides a sampler.

The purpose of the invention is realized by the following technical scheme: the utility model provides a sampler, including casing and sampling needle, including holding chamber and contact pin chamber in the casing, the liquid outlet has been seted up on the bottom lateral wall in contact pin chamber, hold chamber and contact pin chamber and pass through the liquid outlet intercommunication, it installs the test paper to hold the intracavity, the sampling needle includes syringe needle and cylinder, the inner chamber of cylinder is the stock solution chamber of storing reagent liquid, the sealing plug is sealed through at the top in stock solution chamber, the bottom in stock solution chamber is provided with easily decreases the structure, the cylinder inserts the contact pin intracavity, and the syringe needle supports the bottom in contact pin chamber and makes easily decrease the structure damaged, the reagent liquid in the stock solution intracavity flows in through the damaged department of easily decreasing the structure and holds the chamber, and reagent.

Optionally, the easily damaged structure comprises a groove a, the groove a is arranged at the bottom of the liquid storage cavity, the bottom of the groove a is a easily damaged thin wall, and the needle head is arranged on the bottom surface of the easily damaged thin wall.

Optionally, the shell comprises a barrel body and a bottom shell, the bottom shell is hermetically mounted at the bottom of the barrel body, a partition plate is arranged in the barrel body, the partition plate divides an inner cavity of the barrel body into a containing cavity and a pin cavity, the top of the pin cavity is open, and the top of the containing cavity is a closed opening.

Optionally, a clamping groove a is formed in the top of the bottom shell located at the accommodating cavity, a clamping plate is arranged at the bottom of the barrel located at the top of the accommodating cavity, a limiting cavity is formed between the inner side wall of the barrel far away from the inserting needle cavity and the clamping plate, a supporting plate is clamped in the limiting cavity, the bottom of the supporting plate is clamped in the clamping groove a, and test paper is installed on one side, far away from the inserting needle cavity, of the supporting plate.

Optionally, one side of the supporting plate, which is far away from the needle cavity, is provided with a plurality of convex edges, a clamping groove b is formed between two adjacent convex edges, the test paper is clamped in the clamping groove b, and the bottom of the clamping groove b is provided with a liquid inlet.

Optionally, the rib is attached to the inner side wall of the barrel.

Optionally, an annular groove is formed in the outer side wall of the top of the needle cylinder, a sealing ring is sleeved in the annular groove, and the sealing ring is extruded between the needle cavity and the annular groove.

Optionally, the top of the needle cylinder is provided with a radially outward protruding limiting ring, the top of the needle cavity is provided with a limiting notch, and the bottom of the limiting ring is attached to the top of the limiting notch.

Optionally, the needle head comprises a needle rod and a needle point, the needle rod is connected with the bottoms of the grooves a, a plurality of grooves b are axially formed in the outer edge of the needle rod and extend to the needle point, a plurality of separation ribs arranged at intervals are axially arranged in the grooves b, and the grooves b between the two adjacent separation ribs form accommodating cavities in the axial direction.

Optionally, the needle rod is cylindrical, the needle tip is conical, the bottom of the needle tip is a flat surface, and the axial lines of the needle head and the groove a are collinear.

The invention has the following advantages: the sampler provided by the invention has a simple structure, is convenient to operate, can screen high risk people of intestinal cancer and gastric cancer at home by ordinary people, is ingenious in structural design, is in a fully sealed state after being assembled, can be placed at will after being detected completely by operators, and does not need to worry about the problems of leakage, pollution and the like of reagent samples, so that the core problems of difficult stool sampling and inspection, difficult transportation, difficult sample retention, sample pollution and the like are solved, the sampler can be popularized globally, the global death rate of intestinal cancer can be effectively reduced, the intestinal cancer and gastric cancer screening can be completed at home, and the social significance is great.

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a schematic structural view of the housing;

FIG. 3 is a schematic cross-sectional view of the housing;

FIG. 4 is a schematic view of the bottom case

FIG. 5 is a schematic view showing the mounting of the test paper on the support plate

FIG. 6 is a schematic view of the structure of the sampling needle

FIG. 7 is a schematic cross-sectional view of a sampling needle;

FIG. 8 is a schematic view of the needle;

FIG. 9 is an enlarged view taken at I in FIG. 7;

FIG. 10 is a schematic structural view of the assembled sampling needle and housing;

in the figure, 100-needle head, 200-needle cylinder, 300-sealing plug, 201-sealing ring, 202-limiting ring, 203-liquid storage cavity, 204-vulnerable structure, 205-groove a, 206-vulnerable thin wall, 101-needle rod, 102-needle point, 103-groove b, 104-separating rib, 105-flat surface, 106-accommodating cavity, 401-cylinder, 402-bottom shell, 403-clapboard, 404-needle inserting cavity, 405-accommodating cavity, 406-liquid outlet, 407-test paper, 408-supporting plate, 409-clamping plate, 410-limiting notch, 411-clamping groove a, 412-convex edge, 413-clamping groove b and 414-liquid inlet.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings of the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all embodiments of the present invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.

Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.

In addition, the embodiments of the present invention and the features of the embodiments may be combined with each other without conflict.

It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, or orientations or positional relationships that the products of the present invention conventionally lay out when in use, or orientations or positional relationships that are conventionally understood by those skilled in the art, which are merely for convenience of describing the present invention and simplifying the description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and the like are used merely to distinguish one description from another, and are not to be construed as indicating or implying relative importance.

In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

As shown in fig. 1, a sampler comprises a housing 400 and a sampling needle, in this embodiment, as shown in fig. 2 and 3, the housing 400 is made of transparent plastic, and the inside of the housing 400 can be directly observed through the housing 400, the housing 400 includes a containing cavity 405 and a needle cavity 404, a liquid outlet 406 is formed on a side wall of the bottom of the needle cavity 404, the containing cavity 405 and the needle cavity 404 are communicated through the liquid outlet 406, a test paper 407 is installed in the containing cavity 405, further, the housing 400 includes a cylinder 401 and a bottom shell 402, the bottom shell 402 is hermetically installed at the bottom of the cylinder 401, the bottom shell 402 and the cylinder 401 are in a close fit relationship, when the bottom shell 402 and the cylinder 401 are assembled, the bottom shell 402 is difficult to be disassembled, a partition 403 is arranged in the cylinder 401, the partition 403 divides the inner cavity of the cylinder 401 into the containing cavity 405 and the needle cavity 404, the top of the needle cavity 404 is open, and the top of the containing cavity 405 is closed, in this embodiment, the bulkhead 403 is arcuate and the pin cavity 404 is cylindrical.

In this embodiment, as shown in fig. 4, a clamping groove a411 is formed in the top of the bottom shell 402 located at the accommodating cavity 405, a clamping plate 409 is disposed at the bottom of the cylinder 401 located at the top of the accommodating cavity 405, a limiting cavity is formed between the inner side wall of the cylinder 401 far away from the pin cavity 404 and the clamping plate 409, a supporting plate 408 is clamped in the limiting cavity, the bottom of the supporting plate 408 is clamped in the clamping groove a411, and a test paper 407 is mounted on one side of the supporting plate 408 far away from the pin cavity 404, so that the test paper 407 is close to the side wall of the accommodating cavity 405, and data observation and data reading are facilitated.

To facilitate the installation of the test paper 407, as shown in fig. 5, a plurality of ribs 412 are disposed on one side of the support plate 408 away from the pin cavity 404, a slot b413 is formed between two adjacent ribs 412, the test paper 407 is clamped in the slot b413, a liquid inlet 414 is disposed at the bottom of the slot b413, a reagent liquid can flow in through the liquid inlet 414 and contact with the test paper 407, so that the test paper 407 is soaked by the reagent liquid, the liquid can slowly climb to contact with the test paper 407 under the action of chromatography, a sample can react with the test paper 407 for 5-10 minutes to judge the chromatography reaction result through the test paper 407, the test paper 407 has a C-line T mark, only one C-line is negative, both the C-line and the T-line show positive, and the C-line T has no display line, and the test fails.

In this embodiment, the ribs 412 engage the inner sidewall of the barrel 401 to enable the support plate 408 to be secured within the receiving cavity 405.

In this embodiment, as shown in fig. 6 and 7, the sampling needle includes a needle 100 and a syringe 200, the inner cavity of the syringe 200 is a liquid storage cavity 203 for storing reagent liquid, the bottom of the liquid storage cavity 203 is sealed by the bottom of the syringe 200, the top of the liquid storage cavity 203 is sealed by a sealing plug 300, and after the reagent liquid is filled in the liquid storage cavity 203, both ends of the liquid storage cavity 203 are sealed, so that the test liquid does not leak.

In this embodiment, the bottom of the liquid storage cavity 203 is provided with a fragile structure 204, the bottom of the fragile structure 204 is provided with a needle 100, further, as shown in fig. 8, the needle comprises a needle rod 101 and a needle tip 102, the needle rod 101 is connected with the needle tip 102, and the needle rod 101 is connected with the bottom of the fragile structure, in this embodiment, the needle rod 101 and the needle tip 102 are integrally formed, the outer edge of the needle rod 101 is axially provided with a plurality of grooves b103, preferably, the grooves b103 are uniformly distributed on the same circumference, and the number of the grooves b103 is four, so that the included angle between two adjacent grooves b103 in the circumferential direction is 90 degrees, the grooves b103 extend to the needle tip 102, the grooves b103 are axially provided with a plurality of spaced ribs 104, in the axial direction, the grooves b103 between two adjacent ribs 104 form accommodating cavities 106, the cross section of the ribs 104 is fan-shaped, when the needle is inserted into feces, and when the needle is separated from the feces, the stool remains in the receiving chamber 106, thereby allowing the stool to be extracted.

In this embodiment, the needle tip 102 is conical, the bottom of the needle tip 102 is a flat surface 105, the conical needle tip 102 facilitates insertion of the needle into feces, the bottom of the needle tip 102 is set to be the flat surface 105, after the flat surface 105 of the needle tip 102 contacts with the feces, the direction of the force applied to the needle tip 102 is the axial direction, so that the needle rod 101 is not easily subjected to a shearing force, the needle rod 101 is not easily broken when encountering hard feces, the pressure applied to the needle tip 102 is transmitted to the fragile structure 204 after the needle tip 102 contacts with the bottom shell 402, and since the bottom surface of the needle tip 102 is the flat surface 105, the needle tip 102 does not pierce through the bottom shell 402, and when the fragile structure 204 is subjected to an excessive external force, the fragile structure 204 is damaged, the reagent liquid in the liquid storage cavity 203 flows into the barrel 401, and when the reagent liquid flows into the barrel 401, the reagent liquid washes the needle tip 100, and washes the feces in the accommodation cavity 106 into the barrel 401, thereby mixing the feces with the reagent solution, and the mixed reagent solution contacts the test paper 407, so that the result of the chromatographic reaction is interpreted by the test paper 407.

In this embodiment, as shown in fig. 9, the vulnerable structure 204 includes a groove a205, the groove a205 is opened at the bottom of the reservoir 203, the bottom of the groove a205 is a vulnerable thin wall 206, the needle 100 is disposed on the bottom surface of the vulnerable thin wall 206, in this embodiment, needle 100, barrel 200 and frangible mechanism are formed integrally, and further, groove a205 is a circular groove, the axes of needle 100 and groove a205 are collinear, in use, after needle 100 is in contact with bottom housing 402, as the operator continues to depress barrel 200, thereby subjecting the needle 100 to forces, the needle 100 transmitting the forces to the frangible thin wall 206, when the external force reaches the set value, the vulnerable thin wall 206 is torn, at this time, the syringe 200 continues to descend, the needle 100 enters the liquid storage cavity 203, and when the fragile thin wall 206 is torn, the reagent liquid flows into the barrel 401 from the torn part, and is mixed with the excrement in the flowing process.

In this embodiment, an annular groove is formed on the outer side wall of the top of the syringe 200, a sealing ring 201 is sleeved in the annular groove, a cavity for mounting the syringe 200 is arranged on the housing 400 of the sampler, when the sealing ring 201 enters the cavity, the sealing ring 201 seals the cavity and the needle insertion cavity 404, so as to prevent the reagent solution from flowing out from a gap between the cavity and the cylinder 401, thereby ensuring the use reliability of the sampler, further, the needle insertion cavity 404 is a circular cavity, the syringe 200 is also circular, and the outer diameter of the syringe 200 is smaller than the inner diameter of the needle insertion cavity 404, so as to facilitate the insertion of the syringe 200.

In this embodiment, sealing washer 201 is the toper in axial direction to be convenient for sealing washer 201 extrusion to enter into contact pin chamber 404, along with the continuous insertion of cylinder 200, sealing washer 201 then seals the top of cylinder 200 and the top in contact pin chamber 404, thereby avoids reagent liquid to leak and influences operating personnel operation and pollute external environment, consequently when the sample thief uses the completion after, the sample thief can be put at will, need not to worry the problem that reagent liquid leaked.

In this embodiment, the top of the syringe 200 is provided with a radially outwardly protruding retaining ring 202, the top of the needle insertion cavity 404 is provided with a retaining notch 410, the bottom of the retaining ring 202 is attached to the top of the retaining notch 410, the retaining ring 202 can play a role in retaining, after the retaining ring 202 contacts the retaining notch 410, it is indicated that the syringe 200 is in place to move downward, at this time, the syringe 200 does not need to be pressed, and the assembly process of the syringe 200 and the housing 400 is completed.

In this embodiment, the sealing ring 201 is made of rubber, and the sealing plug 300 is made of rubber.

In this embodiment, the needle rod 101 may be a polygon prism or a cylinder, preferably, the needle rod 101 is cylindrical, and the groove b103 may be a U-shaped groove, a trapezoidal groove or a triangular groove, preferably, the cross section of the groove b103 is triangular, so that the needle rod 101 is convenient to machine.

In this embodiment, a housing 400 and a sampling needle are contained in a sterile package, and the test paper 407 is already mounted in the housing 400 in the containing cavity 405, and the reagent solution is stored in the storage cavity of the syringe 200. in use, the package is torn open, the sampling needle is removed, and the feces is extracted, and the sampling needle is then mounted in the insertion cavity 404 of the housing 400.

The working process of the invention is as follows: an operator tears the sterile packaging bag open, then takes out the sampling needle, inserts the sampling needle into the feces to be detected, extracts the feces sample, then inserts the needle head of the sampling needle from the needle inserting cavity 404, the needle head 100 interferes with the bottom shell 402 along with the insertion of the sampling needle, the needle head 100 is blocked by the bottom shell 402, along with the continuous pressing of the sampling needle by the operator, the needle head 100 transmits force to the vulnerable mechanism, so that the vulnerable thin wall 206 is torn, the sampling needle can continuously descend, at the moment, as shown in figure 10, the needle rod 101 of the needle head 100 enters the liquid storage cavity 203, the reagent liquid flows into the needle inserting cavity 404 from the tearing opening and then flows into the accommodating cavity 405 through the liquid outlet 406, the reagent liquid is mixed with the feces sample in the flowing process, when the limiting ring 202 abuts against the limiting notch 410, the sampling needle descends to a proper position, at the moment, the shell 400 is in a completely sealed state, an operator can shake the shell 400 to fully mix the reagent liquid and the excrement, when the reagent liquid contacts the test paper 407, the reagent liquid soaks the test paper 407, the test paper 407 can be used for judging and reading a chromatography reaction result after reacting for 5-10 minutes, the test paper 407 is marked with a line C and a line T, only one line C is negative, and both the line C and the line T are positive.

Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes in the embodiments and/or modifications of the invention can be made, and equivalents and modifications of some features of the invention can be made without departing from the spirit and scope of the invention.

Claims (10)

1. A sampler, characterized by: including casing and sampling needle, including holding chamber and contact pin chamber in the casing, the liquid outlet has been seted up on the bottom lateral wall in contact pin chamber, hold the chamber with the contact pin chamber passes through the liquid outlet intercommunication, hold the intracavity and install the test paper, the sampling needle includes syringe needle and cylinder, the stock solution chamber of inner chamber for storing reagent liquid of cylinder, the sealing plug is sealed through at the top in stock solution chamber, the bottom in stock solution chamber is provided with easily damaged structure, the cylinder inserts the contact pin intracavity, just the syringe needle supports the bottom in contact pin chamber makes easily damaged structure is damaged, the reagent liquid of stock solution intracavity passes through easily damaged department of structure flows in hold the chamber, just reagent liquid with the test paper contact.

2. A sampler according to claim 1, wherein: the easy-damage structure comprises a groove a, the groove a is formed in the bottom of the liquid storage cavity, the bottom of the groove a is an easy-damage thin wall, and the needle head is arranged on the bottom surface of the easy-damage thin wall.

3. A sampler as claimed in claim 1 or 2, wherein: the shell comprises a barrel body and a bottom shell, the bottom shell is mounted at the bottom of the barrel body in a sealing mode, a partition plate is arranged in the barrel body and divides an inner cavity of the barrel body into a containing cavity and a pin cavity, the top of the pin cavity is open, and the top of the containing cavity is a closed opening.

4. A sampler according to claim 3, characterised in that: the test paper box comprises a bottom shell, a containing cavity and a supporting plate, wherein the bottom of the bottom shell is provided with a clamping plate, the clamping plate is arranged at the top of the bottom shell, the clamping plate is arranged at the top of the containing cavity, a limiting cavity is formed between the inner side wall of the barrel, away from the inserting needle cavity, and the clamping plate, a supporting plate is clamped in the limiting cavity, the bottom of the supporting plate is clamped in the clamping groove, and the test paper is arranged on one side, away from the inserting needle cavity, of the supporting plate.

5. The sampler of claim 4, wherein: one side of the supporting plate, which is far away from the needle cavity, is provided with a plurality of convex edges, a clamping groove b is formed between every two adjacent convex edges, the test paper is clamped in the clamping groove b, and the bottom of the clamping groove b is provided with a liquid inlet.

6. The sampler of claim 5, wherein: the convex edge is attached to the inner side wall of the barrel.

7. A sampler according to claim 1, wherein: an annular groove is formed in the outer side wall of the top of the needle cylinder, a sealing ring is sleeved in the annular groove, and the sealing ring is extruded between the needle cavity and the annular groove.

8. A sampler according to claim 1, wherein: the top of the needle cylinder is provided with a radially outward protruding limiting ring, the top of the needle cavity is provided with a limiting notch, and the bottom of the limiting ring is attached to the top of the limiting notch.

9. A sampler according to claim 2, wherein: the needle head comprises a needle rod and a needle point, the needle rod is connected with the bottoms of the grooves a, a plurality of grooves b are axially formed in the outer edge of the needle rod and extend to the needle point, a plurality of separation ribs arranged at intervals are axially arranged in the grooves b, and in the axial direction, the grooves b between two adjacent separation ribs form an accommodating cavity.

10. A sampler according to claim 9, wherein: the needle rod is cylindrical, the needle point is conical, the bottom of the needle point is a flat surface, and the axial leads of the needle head and the groove a are collinear.

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