CN113368361B - Method for regulating level of galanin in brain through acoustic nerve conduction - Google Patents
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
- A61M21/02—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04R—LOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
- H04R1/00—Details of transducers, loudspeakers or microphones
- H04R1/10—Earpieces; Attachments therefor ; Earphones; Monophonic headphones
- H04R1/1083—Reduction of ambient noise
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04R—LOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
- H04R3/00—Circuits for transducers, loudspeakers or microphones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
- A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
- A61M2021/0027—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the hearing sense
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- Health & Medical Sciences (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
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- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Signal Processing (AREA)
- Pain & Pain Management (AREA)
- Percussion Or Vibration Massage (AREA)
- Soundproofing, Sound Blocking, And Sound Damping (AREA)
Abstract
The invention discloses a method for regulating the level of the brain galanin through acoustic conduction of an acoustic nerve, wherein the intensity and the frequency of sound are set through a sound regulating device, and the regulated sound stimulates a cochlea to enable an acoustic nerve internal galanin receptor to generate signal stimulation, and the signal is transmitted into a hypothalamic auditory receiving area through the acoustic nerve so as to regulate the level of the brain galanin and interfere neurotransmitter functions.
Description
Technical Field
The invention relates to the technical field of neuropeptide regulation, in particular to a method for regulating the level of galanin in brain and interfering neurotransmitters through acoustic transmission of auditory nerves.
Background
Galanin (GAL) is a neuropeptide consisting of 30 amino acids, named for glycine and alanine at the N-and C-termini, respectively. GAL is widely distributed in the central and peripheral nervous systems and is involved in mediating multiple biological functions such as feeding, pain, endocrine, neuroprotection, learning and memory, sleep, emotion, sex and reproduction, and is closely related to, inter alia, alzheimer's Disease (AD) pathogenesis, anxiety-depressive emotion production, insomnia, neuronal development and regeneration, and pain sensitivity caused by nerve injury, and also protects nerve cells.
Neurotransmitters such as gamma-aminobutyric acid (GABA), acetylcholine (ACh), glutamic acid (GLu), glycine (GLy), 5-hydroxytryptamine (5-HT) have been shown to play an important role in the processing of auditory information in the hypothalamus (IC). New basic research shows that Galanin (GAL) coexists in the central nervous system with a variety of transmitters, appears in auditory terms as a new and distinct auditory central modulator, and the presence of galanin receptors in the auditory nerve can directly affect, interfere with the actions and functions of neurotransmitters.
Therefore, what means to effectively utilize the auditory center modulator, galanin, is a technical problem to be solved in the art.
Disclosure of Invention
In view of this, the present invention provides a method for regulating the level of brain galanin via acoustic nerve conduction, wherein the intensity and frequency of sound are set by a sound regulating device, and the regulated sound stimulates the cochlea, so that the galanin receptor in the acoustic nerve generates signal stimulation, and the signal is transmitted into the hypothalamic auditory receiving area via the acoustic nerve to regulate the level of brain galanin and interfere with neurotransmitter functions.
Preferably, the sound regulated by the sound regulating device is sound with the frequency of 20-20000 hertz (Hz) and the intensity of 0-120 decibels (db) felt by human ears, and the sound stimulation is performed in a safe area.
Preferably, the sound regulated by the sound regulating means includes, but is not limited to, sounds of different intensities and different frequencies. The intensity and/or frequency may also be fixed.
Preferably, the control process of the sound stimulation cochlea with different intensities and different frequencies is as follows: sound is synthesized and played using the sound adjustment device, and the cochlea is stimulated gradually from weak to strong according to the frequency from low to high until the ear cannot distinguish the sound.
Preferably, the frequency is gradually increased at intervals of 20-40Hz and the sound intensity is gradually increased at intervals of 2-5 db.
Preferably, the sound adjusting means comprises a sound synthesizer and a sound player;
the sound synthesizer is used for carrying out sound wave editing processing according to the frequency from low to high and the intensity from weak to strong;
the sound player is used for playing sound.
Preferably, the sound synthesizer is also used for controlling tone color through waveform modulation, including superposition and transformation of different waveforms.
Waveforms include sine waves, saw tooth waves, triangular waves, square waves, and the like.
Preferably, the sound synthesizer is further provided with a filter, a cut-off frequency.
Preferably, the sound synthesizer is an eqinox synthesis workstation;
the sound player is a high-fidelity noise reduction earphone.
The invention can effectively control the galanin receptor GALR in the auditory nerve through the sound signal and repeatedly stimulate the galanin receptor GALR in the auditory nerve, thereby achieving the purposes of regulating and controlling the GAL concentration in the brain and intervening neurotransmitters through the conduction of the auditory nerve.
Detailed Description
Example 1
A method for regulating the level of galanin in brain by acoustic nerve conduction features that the intensity and frequency of sound are set by sound regulator, and the regulated sound stimulates cochlea to make the receptor of galanin in hypothalamus generate signal stimulus, which is transmitted to auditory receiving area of hypothalamus via acoustic nerve for regulating the level of galanin in brain.
The sound adjusting device comprises a sound synthesizer and a sound player.
The sound synthesizer is an EQUINOX sound synthesis workstation, and the sound player is a wireless high-fidelity noise reduction earphone.
The sound synthesizer is used for editing sine wave type sound according to the frequency from low to high and the intensity from weak to strong; the sound frequency is a modulation section every 20-40 hertz (Hz); the sound intensity (modulating the sound wave amplitude) is one modulation segment every 5 decibels (db). The time of the sound stimulation of each conditioning segment starts from 1 minute and the duration gradually increases.
If necessary, the adjusting interval of the sound frequency can be shortened to 20-30 hertz (Hz), and the adjusting interval of the sound intensity can be shortened to 2-3 decibels (db).
The sound player is used for playing sine wave type sound.
The sine wave sound synthesized by the sound synthesizer is transmitted to the sound player, and the sound player is placed at the external auditory meatus or the external skull of the cochlea to perform sound stimulation.
Different stimulation to the GALR of the cochlea can be realized through the sound stimulation adjustment with different frequencies, different strengths and different durations, and then the GAL level in the brain is adjusted through auditory nerve conduction; while GAL is involved in mediating multiple biological functions of ingestion, pain, endocrine, neuroprotection, learning and memory, sleep, emotion, sex, reproduction, etc., therefore, modulation of sounds of different frequencies, different intensities, different durations is expected to achieve intervention in biological responses in vivo.
Example 2
A method for regulating the level of the galanin in brain by acoustic conduction of auditory nerve includes such steps as controlling the sound with different frequencies, different intensities and different durations by sound regulator to stimulate cochlea, generating signal stimulus by the receptor of galanin in auditory nerve, and transmitting the signal to auditory receiving area of hypothalamus for regulating the level of galanin in brain.
The sound adjusting device comprises a sound synthesizer and a sound player.
The sound synthesizer is an EQUINOX sound synthesis workstation, and the sound player is a wireless high-fidelity noise reduction earphone.
The sound synthesizer is used for carrying out sound wave editing processing according to the frequency from low to high and the intensity from weak to strong; the sound frequency is a modulation section every 20-40 hertz (Hz); the sound intensity (modulating the sound wave amplitude) is one modulation segment every 5 decibels (db). If necessary, the adjusting interval of the sound frequency can be shortened to 20-30 hertz (Hz), and the adjusting interval of the sound intensity can be shortened to 2-3 decibels (db). The time of the sound stimulation of each conditioning segment starts from 1 minute and the duration gradually increases.
The acoustic wave can be selected from non-sinusoidal acoustic waves such as square acoustic waves, sawtooth waves, triangular waves and the like; the sound wave can be changed or overlapped; and sets the filter, cut-off frequency. Comparing the data obtained from different waveforms, looking at commonalities and differences, one can choose a waveform setting that is suitable for an individual or has general applicability.
The sound player is used for playing sound.
The sound synthesized by the sound synthesizer is transmitted to the sound player, and the sound player is placed at the external auditory meatus or the skull outside the cochlea to perform sound stimulation.
Different stimulation to the GALR of the cochlea can be realized through the sound adjustment of different waveforms, different frequencies, different strengths and different durations, and then the GAL level in the brain is adjusted through auditory nerve conduction; while GAL is involved in mediating multiple biological functions of ingestion, pain, endocrine, neuroprotection, learning and memory, sleep, emotion, sex, reproduction, etc., therefore, modulation of sounds of different frequencies, different intensities, different durations is expected to achieve intervention in biological responses in vivo.
Example 3
A method for regulating the level of galanin in brain by acoustic conduction of auditory nerve features that the sound regulator generates the sound stimulating signals with fixed rhythm, frequency, waveform and time to generate signal stimulation to the receptor of galanin in auditory nerve, and the signal is transmitted to auditory receiving area of hypothalamus for regulating the level of galanin in brain.
On the basis of knowing acoustic nerve conduction regulation, sine waves, square waves, sawtooth waves, filters, cut-off frequencies and the like can be randomly overlapped through the acoustic regulating device, or irregular waveforms can be automatically created, music is formed under fixed rhythms, fixed time length, fixed frequencies and fixed strength, and GALR in acoustic nerves can be repeatedly stimulated, so that the GAL level in brain is regulated through acoustic nerve conduction.
The sound recreating can directly influence the ingestion, pain sense, endocrine, neuroprotection, learning and memory, sleep, emotion, sex and reproduction and other biological functions of a human body.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to the embodiments described above will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (6)
1. A method for regulating the level of the brain galanin through acoustic nerve conduction, which is characterized in that the intensity and the frequency of sound are set through a sound regulating device, the regulated sound stimulates a cochlea, so that an acoustic nerve galanin receptor generates signal stimulation, and the signal is transmitted into a hypothalamic auditory receiving area through the acoustic nerve to regulate the level of the brain galanin and interfere with neurotransmitter functions;
the sound regulated by the sound regulating device comprises sounds with different intensities and different frequencies;
the control process of the sound stimulation cochlea with different intensities and different frequencies comprises the following steps: sound is synthesized and played using the sound adjustment device, and the cochlea is stimulated gradually from weak to strong according to the frequency from low to high until the ear cannot distinguish the sound.
2. The method for regulating the level of galanin in brain through acoustic nerve conduction according to claim 1, wherein the sound regulated by the sound regulating device is a sound with the frequency of 20-20000 hz and the intensity of 0-120 db, which can be perceived by human ear.
3. The method of claim 1, wherein the sound modulation device comprises a sound synthesizer and a sound player;
the sound synthesizer is used for carrying out sound wave editing processing according to the frequency from low to high and the intensity from weak to strong;
the sound player is used for playing sound.
4. A method of modulating brain galanin levels via acoustic nerve conduction according to claim 3, wherein the sound synthesizer is further adapted to control tone color by waveform modulation, including superposition, transformation of different waveforms.
5. The method of claim 4, wherein the sound synthesizer further sets a filter, cut-off frequency.
6. A method of modulating the level of galanin in the brain via acoustic nerve conduction according to claim 3, wherein the sound synthesizer is an eqinox synthesis workstation; the sound player is a high-fidelity noise reduction earphone.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013169741A1 (en) * | 2012-05-08 | 2013-11-14 | Stein Emily A | Agents and devices for affecting nerve function |
| CN107049309A (en) * | 2017-05-16 | 2017-08-18 | 深圳先进技术研究院 | Auditory brainstem response detection method and device |
| WO2017165237A1 (en) * | 2016-03-21 | 2017-09-28 | The Regents Of The University Of California | Inhibitory sleep-circuit neurons and methods of modulating a stable state by regulating the same |
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| US20090215671A1 (en) * | 2005-05-27 | 2009-08-27 | The Regents Of The University Of California | Compositions And Methods For Treatment of Neural Disorders Using Transforming Growth Factor-Beta Superfamily Proteins And Their Antagonists |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013169741A1 (en) * | 2012-05-08 | 2013-11-14 | Stein Emily A | Agents and devices for affecting nerve function |
| WO2017165237A1 (en) * | 2016-03-21 | 2017-09-28 | The Regents Of The University Of California | Inhibitory sleep-circuit neurons and methods of modulating a stable state by regulating the same |
| CN107049309A (en) * | 2017-05-16 | 2017-08-18 | 深圳先进技术研究院 | Auditory brainstem response detection method and device |
Non-Patent Citations (2)
| Title |
|---|
| 李光鹏等.《动物解剖学、组织学与生殖生物学简明教程》.内蒙古大学出版社,2016,第338-339页. * |
| 甘丙肽对IC神经元声信号处理的调制;王俊波;《中国优秀博硕士学位论文全文数据库 （硕士）基础科学辑》;摘要、论文第1-26页 * |
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