CN113368361A - Method for regulating galanin level in brain through acoustic nerve conduction - Google Patents
Method for regulating galanin level in brain through acoustic nerve conduction Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
- A61M21/02—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04R—LOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
- H04R1/00—Details of transducers, loudspeakers or microphones
- H04R1/10—Earpieces; Attachments therefor ; Earphones; Monophonic headphones
- H04R1/1083—Reduction of ambient noise
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04R—LOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
- H04R3/00—Circuits for transducers, loudspeakers or microphones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
- A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
- A61M2021/0027—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the hearing sense
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Psychology (AREA)
- Signal Processing (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Soundproofing, Sound Blocking, And Sound Damping (AREA)
- Percussion Or Vibration Massage (AREA)
Abstract
The invention discloses a method for regulating the level of galanin in brain through acoustic conduction of auditory nerves, which is characterized in that the intensity and frequency of sound are set through a sound regulating device, the regulated sound stimulates a cochlea, so that galanin receptors in the auditory nerves generate signal stimulation, and signals are transmitted into a hypothalamic auditory receiving area through the auditory nerves to regulate the level of galanin in brain and intervene in neurotransmitter function.
Description
Technical Field
The invention relates to the technical field of neuropeptide regulation, in particular to a method for regulating the level of galanin in brain and intervening neurotransmitter through acoustic nerve conduction.
Background
Galanin (GAL) is a neuropeptide consisting of 30 amino acids, which is named because the N-and C-termini are glycine and alanine, respectively. GAL is widely distributed in central and peripheral nervous systems, and is involved in regulating various biological functions such as feeding, pain sensation, endocrine, neuroprotection, learning and memory, sleep, emotion, sex and reproduction, etc., and is particularly closely related to Alzheimer's Disease (AD) pathogenesis, anxiety and depression emotion generation, insomnia, neuron development and regeneration, and pain sensation sensitivity caused by nerve injury, and GAL also has a protective effect on nerve cells.
It has been shown that neurotransmitters such as gamma-aminobutyric acid (GABA), acetylcholine (ACh), glutamic acid (GLu), glycine (GLy), 5-hydroxytryptamine (5-HT) play an important role in processing of hypothalamic (IC) auditory information. The new basic research shows that Galanin (GAL) coexists with multiple transmitters in the central nervous system, appears as a novel auditory central modulator in auditory aspect, and the existence of galanin receptors in auditory nerves can directly influence and interfere with the action and function of neurotransmitters.
Therefore, what means is to be adopted to effectively utilize galanin, which is an auditory center modulator, is a technical problem to be solved in the field.
Disclosure of Invention
The present invention provides a method for regulating galanin level in brain through acoustic conduction of auditory nerve, wherein the intensity and frequency of sound are set by a sound regulating device, the regulated sound stimulates cochlea, so that galanin receptors in auditory nerve generate signal stimulation, and the signal is transmitted to hypothalamic auditory reception areas through the auditory nerve to regulate galanin level in brain and intervene in neurotransmitter function.
Preferably, the sound modulated by the sound modulation device is a sound having a frequency of 20 to 20000 hertz (Hz) and an intensity of 0 to 120 decibels (db) that can be perceived by the human ear, and the sound stimulation is performed in a region that is safe.
Preferably, the sounds adjusted by the sound adjusting device include, but are not limited to, sounds of different intensities and different frequencies. The intensity and/or frequency may also be fixedly set.
Preferably, the control process of stimulating the cochlea with sounds of different intensities and different frequencies is as follows: the sound adjusting device is used for synthesizing and playing sound, and the cochlea is gradually stimulated from weak to strong according to the frequency from low to high and the sound intensity until the ear cannot distinguish the sound.
Preferably, the frequency is gradually increased at intervals of 20-40Hz, and the sound intensity is gradually increased at intervals of 2-5 db.
Preferably, the sound adjusting means comprises a sound synthesizer and a sound player;
the sound synthesizer is used for carrying out sound wave editing processing according to the frequency from low to high and the intensity from weak to strong;
the sound player is used for playing sound.
Preferably, the sound synthesizer is further adapted to control the timbre by waveform modulation, including superposition, transformation of different waveforms.
The waveforms include sine waves, sawtooth waves, triangular waves, square waves, and the like.
Preferably, the sound synthesizer also sets a filter, cut-off frequency.
Preferably, the sound synthesizer is an EQUINOX synthesizing workstation;
the sound player is a high-fidelity noise-reducing earphone.
The galanin receptor GALR in the auditory nerve is repeatedly stimulated under effective control through the sound signals, and the aims of regulating the GAL concentration in the brain and intervening in neurotransmitters are achieved through conduction of the auditory nerve.
Detailed Description
Example 1
A method for regulating galanin level in brain by acoustic conduction of auditory nerve comprises setting intensity and frequency of sound by sound regulating device, stimulating cochlea with the regulated sound to make galanin receptor in hypothalamus generate signal stimulation, and transmitting the signal to auditory reception region of hypothalamus via auditory nerve to regulate galanin level in brain.
The sound adjusting apparatus includes a sound synthesizer and a sound player.
The sound synthesizer is an EQUINOX sound synthesis workstation, and the sound player is a wireless high-fidelity noise-reduction earphone.
The sound synthesizer is used for editing and processing sine wave sound according to the frequency from low to high and the intensity from weak to strong; sound frequency is a regulation segment every 20-40 hertz (Hz); sound intensity (modulating sound wave amplitude) is a regulation segment every 5 decibels (db). The sound stimulation of each conditioning segment starts from 1 minute and the duration is gradually prolonged.
If necessary, the sound frequency adjustment interval can be shortened to 20-30 hertz (Hz), and the sound intensity adjustment interval can be shortened to 2-3 decibels (db).
The sound player is used for playing sine wave type sound.
The sinusoidal wave type sound synthesized by the sound synthesizer is transmitted to the sound player, and the sound player is placed at the external auditory canal or the external skull of the cochlea to perform sound stimulation.
Through the sound stimulation regulation with different frequencies, different strengths and different durations, different stimulation to GALR of the cochlear part can be realized, and the level of GAL in the brain is regulated through auditory nerve conduction; GAL is involved in regulating multiple biological functions such as feeding, pain sensation, endocrine, neuroprotection, learning and memory, sleep, emotion, sex and reproduction, and thus intervention on biological responses in vivo is expected to be achieved through regulation of sounds of different frequencies, different intensities and different durations.
Example 2
A method for regulating galanin level in brain by acoustic conduction of auditory nerve comprises controlling sounds with different frequencies, intensities and durations to stimulate cochlea by a sound regulating device, so that galanin receptor in auditory nerve generates signal stimulation, and the signal is transmitted to hypothalamic auditory reception region via auditory nerve to regulate galanin level in brain.
The sound adjusting apparatus includes a sound synthesizer and a sound player.
The sound synthesizer is an EQUINOX sound synthesis workstation, and the sound player is a wireless high-fidelity noise-reduction earphone.
The sound synthesizer is used for carrying out sound wave editing processing according to the frequency from low to high and the intensity from weak to strong; sound frequency is a regulation segment every 20-40 hertz (Hz); sound intensity (modulating sound wave amplitude) is a regulation segment every 5 decibels (db). If necessary, the sound frequency adjustment interval can be shortened to 20-30 hertz (Hz), and the sound intensity adjustment interval can be shortened to 2-3 decibels (db). The sound stimulation of each conditioning segment starts from 1 minute and the duration is gradually prolonged.
The sound wave can be selected from non-sinusoidal sound waves such as square sound waves, sawtooth waves, triangular waves and the like; the change or superposition of sound waves can also be carried out; and a filter is set to cut off the frequency. Comparing the data obtained from different waveforms, observing the commonalities and differences, and selecting the waveform settings suitable for individuals or with general applicability.
The sound player is used for playing sound.
The sound synthesized by the sound synthesizer is transmitted to the sound player, and the sound player is placed at the external auditory canal or the external skull of the cochlea to carry out sound stimulation.
Through the sound regulation of different waveforms, different frequencies, different strengths and different durations, different stimulation to the GALR of the cochlea can be realized, and the level of the GAL in the brain is regulated through auditory nerve conduction; GAL is involved in regulating multiple biological functions such as feeding, pain sensation, endocrine, neuroprotection, learning and memory, sleep, emotion, sex and reproduction, and thus intervention on biological responses in vivo is expected to be achieved through regulation of sounds of different frequencies, different intensities and different durations.
Example 3
A method for regulating galanin level in brain by acoustic conduction of auditory nerve comprises generating acoustic stimulation signal with fixed rhythm, fixed frequency, fixed waveform, fixed intensity and fixed stimulation time by acoustic regulator to generate signal stimulation to galanin receptor in auditory nerve, and transmitting the signal to auditory reception region of hypothalamus via auditory nerve to regulate galanin level in brain.
On the basis of understanding the acoustic conduction regulation of the auditory nerve, sine waves, square waves, sawtooth waves, filters, cut-off frequencies and the like can be randomly superposed through a sound regulating device, or irregular waveforms can be automatically created, music is formed under fixed rhythm, fixed duration, fixed frequency and fixed strength, GALR in the auditory nerve can be repeatedly stimulated, and then the GALR level in the brain is regulated through the acoustic conduction of the auditory nerve.
The regeneration of the sound can directly influence a plurality of biological functions of human bodies, such as ingestion, pain sensation, endocrine, neuroprotection, learning and memory, sleep, emotion, sex, reproduction and the like.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to the above-described embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (8)
1. A method for regulating galanin level in brain through acoustic conduction of auditory nerve is characterized in that the intensity and frequency of sound are set through a sound regulating device, the regulated sound stimulates cochlea, so that galanin receptors in auditory nerve generate signal stimulation, and the signal is transmitted to a hypothalamus auditory reception area through the auditory nerve to regulate galanin level in brain and intervene in neurotransmitter function.
2. The method of claim 1, wherein the sound modulated by the sound modulation device is a sound having a frequency of 20 to 20000 hz and an intensity of 0 to 120 db that is perceived by the human ear.
3. The method of claim 1, wherein the sounds modulated by the sound modulation device include, but are not limited to, sounds of different intensities and different frequencies.
4. The method of claim 3, wherein the control process of stimulating cochlea with different intensities and different frequencies of sounds is as follows: the sound adjusting device is used for synthesizing and playing sound, and the cochlea is gradually stimulated from weak to strong according to the frequency from low to high and the sound intensity until the ear cannot distinguish the sound.
5. The method of claim 1, wherein the sound modulation device comprises a sound synthesizer and a sound player;
the sound synthesizer is used for carrying out sound wave editing processing according to the frequency from low to high and the intensity from weak to strong;
the sound player is used for playing sound.
6. The method of claim 5, wherein the sound synthesizer is further configured to control the timbre by waveform modulation, including superposition and transformation of different waveforms.
7. The method of claim 6, wherein the sound synthesizer further comprises a filter and a cut-off frequency.
8. The method of claim 5, wherein the method of modulating galanin levels in the brain via acoustic nerve conduction,
the sound synthesizer is an EQUINOX synthesizing workstation; the sound player is a high-fidelity noise reduction earphone.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090215671A1 (en) * | 2005-05-27 | 2009-08-27 | The Regents Of The University Of California | Compositions And Methods For Treatment of Neural Disorders Using Transforming Growth Factor-Beta Superfamily Proteins And Their Antagonists |
| WO2013169741A1 (en) * | 2012-05-08 | 2013-11-14 | Stein Emily A | Agents and devices for affecting nerve function |
| CN107049309A (en) * | 2017-05-16 | 2017-08-18 | 深圳先进技术研究院 | Auditory brainstem response detection method and device |
| WO2017165237A1 (en) * | 2016-03-21 | 2017-09-28 | The Regents Of The University Of California | Inhibitory sleep-circuit neurons and methods of modulating a stable state by regulating the same |
-
2020
- 2020-02-25 CN CN202010117754.0A patent/CN113368361B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090215671A1 (en) * | 2005-05-27 | 2009-08-27 | The Regents Of The University Of California | Compositions And Methods For Treatment of Neural Disorders Using Transforming Growth Factor-Beta Superfamily Proteins And Their Antagonists |
| WO2013169741A1 (en) * | 2012-05-08 | 2013-11-14 | Stein Emily A | Agents and devices for affecting nerve function |
| WO2017165237A1 (en) * | 2016-03-21 | 2017-09-28 | The Regents Of The University Of California | Inhibitory sleep-circuit neurons and methods of modulating a stable state by regulating the same |
| CN107049309A (en) * | 2017-05-16 | 2017-08-18 | 深圳先进技术研究院 | Auditory brainstem response detection method and device |
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