CN113350435A - 一种组合物在用于制备治疗跌打损伤、骨折脱位、风湿骨病、风湿性关节炎药物中的应用 - Google Patents

一种组合物在用于制备治疗跌打损伤、骨折脱位、风湿骨病、风湿性关节炎药物中的应用 Download PDF

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CN113350435A
CN113350435A CN202110772530.8A CN202110772530A CN113350435A CN 113350435 A CN113350435 A CN 113350435A CN 202110772530 A CN202110772530 A CN 202110772530A CN 113350435 A CN113350435 A CN 113350435A
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张德东
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Abstract

本发明涉及一种治疗跌打损伤、骨折脱位、风湿骨病的外用中草药组合物，它包含：当归、三七、血竭、乳香、没药、豹骨、龙骨、狗骨、麝香、土鳖虫、白芷、苍术、杜仲、松香、续断、川羌活、川山甲、青风藤、骨碎补、接骨木和透骨草。本发明所述的中药组合物功效：活血祛瘀消肿止痛接骨续筋通经散结祛风除湿。主治：跌打损伤，骨折脱位，颈椎病，肩周炎，腰椎间盘突出，风湿类风湿，痛风，骨质增生等引起的各种疼痛。

Description

一种组合物在用于制备治疗跌打损伤、骨折脱位、风湿骨病、 风湿性关节炎药物中的应用
本申请是申请日为2015年11月30日、申请号为201510857003.1、发明名称为《一种治疗跌打损伤、骨折脱位、风湿骨病的外用中草药组合物》的分案申请。
技术领域
本发明涉及医药领域，具体来说涉及一种治疗跌打损伤、骨折脱位、风湿骨病的外用中草药组合物。
背景技术
风湿病是一组以药物治疗为主的肌肉骨骼系统疾病，它包括：弥漫性结缔组织病及各种病因引起的关节和关节周围软组织、肌肉、肌腱、韧带等的疾病，且以四肢大关节肿痛为主。类风湿关节炎是一个累及周围关节为主的多系统性炎症性的自身免疫病，其特征性的症状为对称性、周围多个关节慢性炎症性病变，临床表现为受累关节疼痛、肿胀、功能下降，病变成持续、反复发作过程。其病理为慢性滑膜炎，侵及下层的软骨和骨，造成关节破坏。临床表现：80％发病于35-50岁，女性为男性3倍。特点以缓慢而隐匿方式起病。关节表现有3个特征：①晨僵：夜间及早晨关节僵硬如胶粘。②关节肿痛：最常见为腕、掌骨关节，其次是趾、膝、踝、肘、肩关节。受风寒肿痛加重。③关节畸形：多见于晚期患者。手指、腕、足、趾等关节屈曲畸形。关节周围肌肉萎缩、痉挛则使畸形更为严重。中医认为风湿、类风湿病均因人体正气不足、营卫不和、气血亏损、脏腑虚弱等多种因素或某一种因素的条件下，使风寒湿邪乘虚而入，侵入人体经络、关节、肌肉、骨骼等处，引起上述临床表现。本病还受气候寒冷影响而反复发作，久病不愈者已引起气血严重亏损，导致四肢关节僵硬畸形，活动受限，疼痛难忍，甚至丧失劳动力，给患者带来极大的痛苦。关于风湿和类风湿的病因和发病机理尚未明确，目前认为与自身免疫有关。大多数医疗单位采取控制疼痛为主，服用大量芬必得、扶他林、消炎痛等，有的急性期病人服用大量激素来控制，减轻症状，最终未能摆脱此病带来的痛苦。
发明内容
本发明的目的是提供一种治疗跌打损伤、骨折脱位、风湿骨病的外用中草药组合物。
为了实现本发明的目的，本发明提供一种治疗跌打损伤、骨折脱位、风湿骨病的外用中草药组合物，它包含下列重量份的物质：当归500-600份、三七600-800份、血竭500-600份、乳香400-500份、没药400-500份、豹骨500-700份、龙骨400-500份、狗骨600-800份、麝香30-60份、土鳖虫300-400份、白芷300-400份、苍术300-400份、杜仲300-400份、松香300-500份、续断300-500份、川羌活300-500份、川山甲500-600份、青风藤500-600份、骨碎补400-500份、接骨木400-500份和透骨草400-500份。
优选地，本发明所述的治疗跌打损伤、骨折脱位、风湿骨病的外用中草药组合物包含下列重量份的物质：当归550份、三七700份、血竭550份、乳香450份、没药450份、豹骨600份、龙骨450份、狗骨700份、麝香50份、土鳖虫350份、白芷350份、苍术350份、杜仲350份、松香400份、续断400份、川羌活400份、川山甲550份、青风藤550份、骨碎补450份、接骨木450份和透骨草450份。
更优选地，本发明所述的治疗跌打损伤、骨折脱位、风湿骨病的外用中草药组合物还包含下列重量份的物质：3份的顺式-3-O-[4-(S)-(4-碘苯基)-2-氧代-1,3,2-二氧磷杂环己基]-18β-甘草次酸。
最优选地，所述中草药组合物可以是片剂、分散片、胶囊剂、丸剂或汤剂。
本发明还提供顺式-3-O-[4-(S)-(4-碘苯基)-2-氧代-1,3,2-二氧磷杂环己基]-18β-甘草次酸在制备治疗跌打损伤、骨折脱位、风湿骨病、风湿性关节炎的药物中的用途。
本发明所述的中药组合物功效：活血祛瘀消肿止痛接骨续筋通经散结祛风除湿。主治：跌打损伤，骨折脱位，颈椎病，肩周炎，腰椎间盘突出，风湿类风湿，痛风，骨质增生等引起的各种疼痛。
具体实施方式
下面通过实施例进一步说明本发明。应该理解的是，本发明的实施例是用于说明本发明而不是对本发明的限制。根据本发明的实质对本发明进行的简单改进都属于本发明要求保护的范围。除非另有说明，否则本发明中的百分数是重量百分数。
实施例1
称取当归550克、三七700克、血竭550克、乳香450克、没药450克、豹骨600克、龙骨450克、狗骨700克、麝香50克、土鳖虫350克、白芷350克、苍术350克、杜仲350克、松香400克、续断400克、川羌活400克、川山甲550克、青风藤550克、骨碎补450克、接骨木450克和透骨草450克，粉碎，过100目筛，混合均匀得到粉末。
实验例2
对大鼠角叉菜胶足肿胀的作用
取120-15g雄性健康Wistar大鼠50只，随机分为5组：对照组、阳性药组、给药组1、给药组2、给药组3。每组10只。对照组给予生理盐水灌胃1mL/100g体重；阳性药组给予地塞米松0.5g加1000mL生理盐水配制成混悬液，给予灌胃1mL/100g体重；给药组1，实施例1的粉末10g加1000mL生理盐水配制成混悬液，给予灌胃1mL/100g体重；给药组2，0.02g的顺式-3-
Figure BDA0003154339040000033
[4-(S)-(4-碘苯基)-2-氧代-1,3,2-二氧磷杂环己基]-18β-甘草次酸加1000mL生理盐水配制成混悬液，给予灌胃1mL/100g体重；给药组3，实施例1的粉末5g和0.01g的顺式-3-O-[4-(S)-(4-碘苯基)-2-氧代-1,3,2-二氧磷杂环己基]-18β-甘草次酸加1000mL生理盐水配制成混悬液，给予灌胃1mL/100g体重。1次/日，连续给药7天。末次灌胃后30min，在大鼠后肢右足跖皮下注射l重量％角叉菜胶水溶液0.05m1/只致炎，测量致炎前后大鼠足跖周长变化，计算并比较致炎后各组肿胀百分率。结果见见表1。(n＝10
Figure BDA0003154339040000031
)
Figure BDA0003154339040000032
表1致炎后不同组别的肿胀百分率
组别 2h足肿胀率(％) 4h足肿胀率(％)
对照组 21.6±10.3 45.2±11.3
阳性药组 19.7±9.6 26.5±8.7*
给药组1 21.1±9.2 32.3±10.5*
给药组2 19.9±10.2 27.2±9.3*
给药组3 20.6±11.5 30.1±10.1*
注：与对照组比较*P＜0.05
结果表明，给予角叉菜胶4小时后，与对照组比较，本发明的药物对其足肿胀有显著抑制作用(p＜0.05)，说明有较好的抗炎作用。

Claims (4)

1.一种组合物在用于制备治疗跌打损伤、骨折脱位、风湿骨病、风湿性关节炎疾病药物中的应用，其特征在于，所述组合物由下列重量份的物质组成：当归500～600份、三七600～800份、血竭500～600份、乳香400～500份、没药400～500份、豹骨500～700份、龙骨400～500份、狗骨600～800份、麝香30～60份、土鳖虫300～400份、白芷300～400份、苍术300～400份、杜仲300～400份、松香300～500份、续断300～500份、川羌活300～500份、川山甲500～600份、青风藤500～600份、骨碎补400～500份、接骨木400～500份、透骨草400～500份和3份的顺式-3-O-[4-(S)-(4-碘苯基)-2-氧代-1，3，2-二氧磷杂环己基]-18β-甘草次酸。
2.根据权利要求2所述的应用，其特征在于，所述组合物由下列重量份的物质组成：当归550份、三七700份、血竭550份、乳香450份、没药450份、豹骨600份、龙骨450份、狗骨700份、麝香50份、土鳖虫350份、白芷350份、苍术350份、杜仲350份、松香400份、续断400份、川羌活400份、川山甲550份、青风藤550份、骨碎补450份、接骨木450份、透骨草450份和3份的顺式-3-O-[4-(S)-(4-碘苯基)-2-氧代-1，3，2-二氧磷杂环己基]-18β-甘草次酸。
3.根据权利要求1或2所述的应用，其特征在于，所述药物的应用方式包括内服或外用。
4.根据权利要求3所述的应用，其特征在于，当药物内用时，所述药物的剂型为片剂、分散片、胶囊剂、丸剂或汤剂。
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