CN113633698A - 一种中药微针透皮给药药贴及制备方法 - Google Patents
一种中药微针透皮给药药贴及制备方法 Download PDFInfo
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Abstract
本发明涉及一种中药微针透皮给药药贴及制备方法。采用的原料有:小驳骨、牡丹皮、牡丹籽油、当归、制草乌、苍术、牛膝、没药、白芍、凤仙草、三七、山茱萸、寄生黄、地龙、鸡血藤、川续断、羌活、甘草、辣椒。本发明通过原料配比,采用纯中草药精制而成,药力持久,只需外敷,不用内服,安全无毒,对人体健康没有任何副作用,牡丹籽油可提高药物的渗透性降低传统膏药的带来的过敏现象,并且采用多孔微针透皮给药的方式,不仅可以缓释效果,还可将药物有效组分直接作用皮下,效果好见效快,对皮肤也没有任何损伤,可以显著减少患者的痛苦,通过外敷可长时间作用于病灶,治疗效果明显。
Description
技术领域
本发明属于生物医药技术领域,涉及一种中药微针透皮给药药贴及制备方法。
背景技术
现如今,随着生活压力的不断增加,人们都处于一种快节奏的生活之中,加上平时的饮食没有规律,快餐式饮食,导致人们都处在亚健康状态,长时间的工作增加了腰肌劳损、颈椎病等慢性病的风险,并且,随着老龄化的不断深化,中老年腰、腿、颈、肩疼痛人群占老龄人口的82%以上,且不断增加。对于腰肌劳损,颈肩疼痛等慢性病采用的物理疗法包括按摩、针灸、拔罐等,只适合于配合治疗,并且针灸治疗、电疗虽然无毒副作用,但治疗费用昂贵,治疗时间较长,对病人的经济和生活带来很大的不方便,西药中可采用阿司匹林、芬必得等药物的使用只能起到消炎消肿、止痛、活血化淤的功效,具有有一定的毒副作用,随着人们越来越注重自身健康,西药所带来的负面影响也成为了人们选择药物时的重要考量,而由各类重要所制造而出膏药贴不论是治疗效果还是实用成本对于人们出现颈肩腰腿疼痛时都是极为适用的。
膏药是中药外用的一种,古代称之为薄贴,膏药经皮肤发挥作用,贴膏药疗法是中医临床常用的外治方法之一,它遵循中医辨证论治及中药的功效、主治与归经的原则,充分调动药物互相协调为用的效能,组成多味药物的复方,运用药物互相协调为用的效能,组成多味药物的大复方,以发挥药物的良好效果。由于膏药用于肌表薄贴,所以膏药中取气味具厚的药物,并加以引药率领群药,开结行滞直达病所。
而目前出现了一种微针透皮贴剂,以微米级的多孔微针刺穿皮肤角质层,使贮存在微针多孔结构中药物穿透渗入表皮层,实现快速精确给药,简化药物导入过程,透入皮肤产生消炎,止痛,活血化淤,通经走络,开窍透骨,祛风散寒等功效。
目前市面上的任何一款治疗药剂老隋及肩颈腰腿痛的中药膏贴,都只能暂时缓解患者的疼痛感,消肿止痛的效果并不明显,无法根治。
发明内容
鉴于现有技术中所存在的问题,本发明公开了一种中药微针透皮给药药贴,采用的技术方案是,膏药的原料按照重量份为:小驳骨3-6份、牡丹皮3-6份、牡丹籽油5-10份、当归2-4份、制草乌5-8份、苍术3-6份、牛膝4-6份、没药4-8份、白芍4-8份、凤仙草4-8份、三七4-8份、麝香1-3份、山茱萸2-4份、寄生黄4-8份、地龙8-14份、鸡血藤3-6份、川续断2-5份、羌活2-5份、甘草2-7份、辣椒2-3份、粘合剂3-6份。
作为本发明的一种优选方案,采用热熔胶作为粘合剂。
作为本发明的一种优选方案,膏药的原料按照重量份为:膏药的原料按照重量份为:小驳骨3、牡丹皮3、牡丹籽油5份、当归2份、制草乌5份、苍术3份、牛膝4份、没药4份、白芍4份、凤仙草4份、三七4份、麝香1份、山茱萸2份、寄生黄4份、地龙8份、鸡血藤3份、川续断2份、羌活2份、甘草2份、辣椒2份、粘合剂3份。
鉴于现有技术中所存在的问题,本发明公开了一种中药微针透皮给药药贴制备方法,包括以下步骤:
(1)称取小驳骨、牡丹皮、当归、制草乌、苍术、牛膝、没药、白芍、凤仙草、三七、、山茱萸、寄生黄、地龙、鸡血藤、川续断、羌活、甘草、辣椒,将各种原料利用液氮进行冷冻干燥粉碎并混合。。
(2)将混合原料利用超临界CO2工艺对中药中有效成分,生物活性分子,生物碱进行萃取和分离,获取萃取物,并将萃取物用纯化水溶解,超声分散加热至60度保温制成萃取物溶剂。
(3)萃取物溶剂与牡丹籽油进行混合,保温搅拌蒸发有机溶剂后,超声分散,并将所得悬浮产品利用高压均质机进行浓缩获取产品。
(4)采用激光-蚀刻法将基板的正面切削成0.5*0.5cm大小的微针单元,将所述微针单元放置在产品中,填充晾干,将处理后的基板利用粘合剂粘合在药膏空白贴上并利用背贴覆盖封闭。
作为本发明的一种优选方案,当归,别名十归、秦归。具有补血,活血,调经止痛,润燥滑肠的功效。主治月经不调,经闭,痛经,症瘕结聚,崩漏,虚寒腹痛,痿痹,肌肤麻木,肠燥便难,赤痢后重,痈疽疮疡,跌扑损伤。味苦,性温,入心、肝、脾经。
作为本发明的一种优选方案,制草乌,具有祛风除湿,温经止痛的作用,用于风寒湿痹,关节疼痛,心腹泠痛,寒疝止痛,味辛、苦,性热,心、肝经。
作为本发明的一种优选方案,苍术,又名山精、赤术、马蓟,具有燥湿健脾,祛风散寒的功效,主治湿阻中焦证,风湿痹证,风寒挟湿表证,夜盲症及眼目昏涩,脾、肝经。
作为本发明的一种优选方案,牛膝,具有逐瘀通经,补肝肾,强筋骨,利尿通淋,引血下行的作用,主要用于经闭,痛经,腰膝酸痛,筋骨无力,淋证,水肿,头痛,眩晕,牙痛,日疮,吐血,衄血,归肝、肾经。
作为本发明的一种优选方案,没药,别名末药,明没药。具有活血止痛,消肿生肌的功效。主治胸腹瘀痛,痛经,经闭,症瘕,跌打损伤,痈肿疮疡,肠痈,目赤肿痛。味苦,性平。归肝经。
作为本发明的一种优选方案,白芍,又名青羊参,味甘、辛,性温,用于风湿痹痛,肾虚腰痛,腰肌劳损,跌扑闪挫,食积,脘腹胀痛,小儿疳积,蛇、犬咬伤,归肝、脾、肾经。
作为本发明的一种优选方案,凤仙草,有活血化瘀、利尿解毒、通经透骨之功效,用于治疗关节风湿痛,跌打损伤,瘰疬痈疽,疔疮,味辛,归肝、肺经。
作为本发明的一种优选方案,三七,甘、微苦,温,具有散瘀止血,消肿定痛的功效,用于咯血,吐血,衄血,便血,崩漏,外伤出血,胸腹刺痛,跌扑肿痛,归肝、胃经。
作为本发明的一种优选方案,小驳骨,名接骨木、接骨筒、乌骨黄藤是一种可以治疗多种疾病的草药,尤其是跌打损伤诸症,疗效尤佳。
作为本发明的一种优选方案,山茱萸,性味酸涩、入肝、肾经,可健胃、补肝肾、治贫血、腰痛、神经及心脏衰弱等症。
作为本发明的一种优选方案,牡丹皮,苦、辛,微寒,归心、肝、肾经,具有清热凉血、活血化淤、退虚热等功效。牡丹皮和牡丹酚的毒性小。
作为本发明的一种优选方案,寄生黄,性辛,平,用于理气健胃,清热利湿,解毒。治胃气痛,黄疸病,痔疮。
作为本发明的一种优选方案,川续断,味苦、辛,性微温,归肝,肾经,主要功效为补肝肾、强筋骨,调血脉,止崩漏,主治腰膝酸痛,肢节痿痹;跌扑创伤、损筋折骨、胎动漏红、血崩、遗精、带下、痈疽疮肿。
作为本发明的一种优选方案,羌活,味辛,苦,性温,归膀胱,肾经,散表寒,祛风湿,利关节,止痛,主外感风寒,头痛无汗,风水浮肿毒。
作为本发明的一种优选方案,甘草,具有调和众药之功,常与芍药同用,能显著增强治挛急疼痛的疗效
作为本发明的一种优选方案,热熔胶,可塑性的粘合剂,常温呈固体状态,加热融化后能快速粘接,并且可反复加热,多次粘结,性能稳定便于储存运输,成本较低。
本发明的有益效果:本发明通过采用纯中草药精制而成,对腰肌劳损、跌打损伤、炎症及肩颈腰腿痛等症状均有显著疗效,原料易得,药力持久,只需外敷,不用内服,安全无毒,对人体健康没有任何副作用,牡丹籽油可提高药物的渗透性降低传统膏药的带来的过敏现象,并且采用多孔微针透皮给药的方式,不仅可以缓释效果,还可将药物有效组分直接作用皮下,效果好见效快,对皮肤也没有任何损伤,可以显著减少患者的痛苦和医疗费用负担。
具体实施方式
实施例1
本发明所述的一种中药微针透皮给药药贴,膏药的原料按照重量份为:小驳骨4份、牡丹皮4份、牡丹籽油7份、当归2份、制草乌5份、苍术3份、牛膝4份、没药4份、白芍4份、凤仙草4份、三七4份、麝香1份、山茱萸2份、寄生黄4份、地龙8份、鸡血藤3份、川续断2份、羌活2份、甘草2份、辣椒2份、粘合剂3份。
本发明所述的一种中药微针透皮给药药贴制备方法,包括以下步骤:
(1)称取小驳骨4份、牡丹皮4份、当归2份、制草乌5份、苍术3份、牛膝4份、
没药4份、白芍4份、凤仙草4份、三七4份、麝香1份、山茱萸2份、寄生黄4份、地龙8份、鸡血藤3份、川续断2份、羌活2份、甘草2份、辣椒2份、粘合剂3份,将各种原料利用液氮进行冷冻干燥粉碎并混合。。
(2)将混合原料利用超临界CO2工艺对中药中有效成分,生物活性分子,生物碱进行萃取和分离,获取萃取物,并将萃取物用纯化水溶解,超声分散加热至60度保温制成萃取物溶剂。
(3)萃取物溶剂与牡丹籽油进行混合,保温搅拌蒸发有机溶剂后,超声分散,并将所得悬浮产品利用高压均质机进行浓缩获取产品。
(4)采用激光-蚀刻法将基板的正面切削成0.5*0.5cm大小的微针单元,将所述微针单元放置产品中,填充晾干,将处理后的基板利用粘合剂粘合在药膏空白贴上并利用背贴覆盖封闭。
作为本发明的一种优选方案粘合剂选用热熔胶。
实施例2
本发明所述的一种中药微针透皮给药药贴,膏药的原料按照重量份为:小驳骨6份、牡丹皮6份、牡丹籽油10份、当归4份、制草乌8份、苍术6份、牛膝6份、没药8份、白芍8份、凤仙草8份、三七8份、麝香3份、山茱萸4份、寄生黄8份、地龙14份、鸡血藤6份、川续断5份、羌活5份、甘草7份、辣椒3份、粘合剂6份。
本发明所述的一种中药微针透皮给药药贴制备方法,包括以下步骤:
(1)称取小驳骨6份、牡丹皮6份、、当归4份、制草乌8份、苍术6份、牛膝6
份、没药8份、白芍8份、凤仙草8份、三七8份、麝香3份、山茱萸4份、寄生黄8
份、地龙14份、鸡血藤6份、川续断5份、羌活5份、甘草7份、辣椒3份、粘合剂
6份,将各种原料利用液氮进行冷冻干燥粉碎并混合。。
(2)将混合原料利用超临界CO2工艺对中药中有效成分,生物活性分子,生物碱进行萃取和分离,获取萃取物,并将萃取物用纯化水溶解,超声分散加热至60度保温制成萃取物溶剂。
(3)萃取物溶剂与牡丹籽油进行混合,保温搅拌蒸发有机溶剂后,超声分散,并将所得悬浮产品利用高压均质机进行浓缩获取产品。
(4)采用激光-蚀刻法将基板的正面切削成0.5*0.5cm大小的微针单元,将所述微针单元放置在产品中,填充晾干,将处理后的基板利用粘合剂粘合在药膏空白贴上并利用背贴覆盖封闭。
作为本发明的一种优选方案粘合剂选用热熔胶。
实施例3
本发明所述的一种中药微针透皮给药药贴,膏药的原料按照重量份为:小驳骨4份、牡丹皮5份、牡丹籽油7份、当归3份、制草乌6份、苍术4份、牛膝5份、没药6份、白芍6份、凤仙草6份、三七6份、麝香2份、山茱萸3份、寄生黄6份、地龙10份、鸡血藤4份、川续断4份、羌活3份、甘草5份、辣椒2份、粘合剂4份。
本发明所述的一种中药微针透皮给药药贴制备方法,包括以下步骤:
(1)称取小驳骨4份、牡丹皮5份、当归3份、制草乌6份、苍术4份、牛膝5份、没药6份、白芍6份、凤仙草6份、三七6份、麝香2份、山茱萸3份、寄生黄6份、地龙10份、鸡血藤4份、川续断4份、羌活3份、甘草5份、辣椒2份、粘合剂4
份,将各种原料利用液氮进行冷冻干燥粉碎并混合。。
(2)将混合原料利用超临界CO2工艺对中药中有效成分,生物活性分子,生物碱进行萃取和分离,获取萃取物,并将萃取物用纯化水溶解,超声分散加热至60度保温制成萃取物溶剂。
(3)萃取物溶剂与牡丹籽油进行混合,保温搅拌蒸发有机溶剂后,超声分散,并将所得悬浮产品利用高压均质机进行浓缩获取产品。
(4)采用激光-蚀刻法将基板的正面切削成0.5*0.5cm大小的微针单元,将所述微针单元放置在产品中,填充晾干,将处理后的基板利用粘合剂粘合在药膏空白贴上并利用背贴覆盖封闭。
上述虽然对本发明的具体实施例作了详细说明,但是本发明并不限于上述实施例,在本领域普通技术人员所具备的知识范围内,还可以在不脱离本发明宗旨的前提下做出各种变化,而不具备创造性劳动的修改或变形仍在本发明的保护范围以内。
Claims (5)
1.一种中药微针透皮给药药贴,其特征在于:膏药的原料按照重量份为:小驳骨3-6份、牡丹皮3-6份、牡丹籽油5-10份、当归2-4份、制草乌5-8份、苍术3-6份、牛膝4-6份、没药4-8份、白芍4-8份、凤仙草4-8份、三七4-8份、麝香1-3份、山茱萸2-4份、寄生黄4-8份、地龙8-14份、鸡血藤3-6份、川续断2-5份、羌活2-5份、甘草2-7份、辣椒2-3份、粘合剂3-6份。
2.根据权利要求1所述的一种中药微针透皮给药药贴,其特征在于:粘合剂采用热熔胶。
3.根据权利要求1所述的一种中药微针透皮给药药贴,其特征在于:膏药的原料按照重量份为:小驳骨3份、牡丹皮3份、牡丹籽油5份、当归2份、制草乌5份、苍术3份、牛膝4份、没药4份、白芍4份、凤仙草4份、三七4份、麝香1份、山茱萸2份、寄生黄4份、地龙8份、鸡血藤3份、川续断2份、羌活2份、甘草2份、辣椒2份、粘合剂3份。
4.根据权利要求1所述的一种中药微针透皮给药药贴,其特征在于:膏药的原料按照重量份为:小驳骨6份、牡丹皮6份、牡丹籽油10份、当归4份、制草乌8份、苍术6份、牛膝6份、没药8份、白芍8份、凤仙草8份、三七8份、麝香3份、山茱萸4份、寄生黄8份、地龙14份、鸡血藤6份、川续断5份、羌活5份、甘草7份、辣椒3份、粘合剂6份。
5.一种中药微针透皮给药药贴制备方法,其特征在于:包括以下步骤:
(1)称取小驳骨、牡丹皮、当归、制草乌、苍术、牛膝、没药、白芍、凤仙草、三七、、山茱萸、寄生黄、地龙、鸡血藤、川续断、羌活、甘草、辣椒,将各种原料利用液氮进行冷冻干燥粉碎并混合。
(2)将混合原料利用超临界CO2工艺对中药中有效成分,生物活性分子,生物碱进行萃取和分离,获取萃取物,并将萃取物用纯化水溶解,超声分散加热至60度保温制成萃取物溶剂。
(3)萃取物溶剂与牡丹籽油进行混合,保温搅拌蒸发有机溶剂后,超声分散,并将所得悬浮产品利用高压均质机进行浓缩获取产品。
(4)采用激光-蚀刻法将基板的正面切削成0.5*0.5cm大小的微针单元,将所述微针单元放置在产品中,填充晾干,将处理后的基板利用粘合剂粘合在药膏空白贴上并利用背贴覆盖封闭。
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