CN113347988A - 修饰的包涵体及其用途 - Google Patents

修饰的包涵体及其用途 Download PDF

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Publication number
CN113347988A
CN113347988A CN202080011043.3A CN202080011043A CN113347988A CN 113347988 A CN113347988 A CN 113347988A CN 202080011043 A CN202080011043 A CN 202080011043A CN 113347988 A CN113347988 A CN 113347988A
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China
Prior art keywords
peptide
ala
gly
leu
lys
Prior art date
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Pending
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CN202080011043.3A
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English (en)
Chinese (zh)
Inventor
约恩·路易林克
沃特·西蒙·彼得鲁斯·钟
亨德里克·巴特·范登伯格范萨帕罗埃亚
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Xbrane Biopharma AB
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Xbrane Bioscience AB
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Publication date
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Publication of CN113347988A publication Critical patent/CN113347988A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202080011043.3A 2019-02-15 2020-02-14 修饰的包涵体及其用途 Pending CN113347988A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19157490.4 2019-02-15
EP19157490 2019-02-15
PCT/EP2020/053933 WO2020165425A1 (en) 2019-02-15 2020-02-14 Decorated inclusion body and uses thereof

Publications (1)

Publication Number Publication Date
CN113347988A true CN113347988A (zh) 2021-09-03

Family

ID=65686666

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080011043.3A Pending CN113347988A (zh) 2019-02-15 2020-02-14 修饰的包涵体及其用途

Country Status (7)

Country Link
US (1) US20220064691A1 (https=)
EP (1) EP3923968A1 (https=)
JP (1) JP2022520550A (https=)
CN (1) CN113347988A (https=)
AU (1) AU2020220637A1 (https=)
CA (1) CA3130159A1 (https=)
WO (1) WO2020165425A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117264081A (zh) * 2023-11-21 2023-12-22 华南理工大学 一种双肽受体激动剂及其制备方法与应用
CN117866110A (zh) * 2023-12-27 2024-04-12 广东唯泰生物科技有限公司 一种靶向flt-3的第四代嵌合抗原受体及其应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112062856A (zh) * 2020-09-16 2020-12-11 华侨大学 一种共价捕获目标蛋白的磁性载体制备方法
EP4408461A1 (en) * 2021-09-30 2024-08-07 AdaptVac ApS Methods and particles for modulating an immune response

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011098772A1 (en) * 2010-02-11 2011-08-18 Isis Innovation Limited Peptide tag systems that spontaneously form an irreversible link to protein partners via isopeptide bonds
WO2018138316A1 (en) * 2017-01-27 2018-08-02 Abera Bioscience Ab New compositions, methods and uses
WO2018162450A1 (en) * 2017-03-06 2018-09-13 Fundación Para La Investigación Médica Aplicada New inmunostimulatory compositions comprising an entity of cold inducible rna-binding protein with an antigen for the activation of dendritic cells

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578308A (en) 1990-02-12 1996-11-26 Capiau; Carine Glutaraldehyde and formalin detoxified bordetella toxin vaccine
CN104884084B (zh) 2012-09-26 2018-05-22 Fvg有限公司 鱼用亚单位浸泡疫苗

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011098772A1 (en) * 2010-02-11 2011-08-18 Isis Innovation Limited Peptide tag systems that spontaneously form an irreversible link to protein partners via isopeptide bonds
WO2018138316A1 (en) * 2017-01-27 2018-08-02 Abera Bioscience Ab New compositions, methods and uses
WO2018162450A1 (en) * 2017-03-06 2018-09-13 Fundación Para La Investigación Médica Aplicada New inmunostimulatory compositions comprising an entity of cold inducible rna-binding protein with an antigen for the activation of dendritic cells

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JONG ET AL.: "Application of an E. coli signal sequence as a versatile inclusion body tag", 《MICROBIAL CELL FACTORIES》, vol. 16, pages 1 - 13 *
NETY, SUCHITA P ET AL.: "Modular Surface Functionalization of Genetically Engineered Gas Vesicle Imaging Agents", 《MOLECULAR IMAGE AND BIOLOGY》, vol. 18, no. 2, 21 December 2016 (2016-12-21), pages 1260 *
TALAFOVÁ ET AL.: "Bacterial inclusion bodies as potential syntheticdevices for pathogen recognition and a therapeutic substance release", 《MICROBIAL CELL FACTORIES》, vol. 12, no. 1, pages 1, XP021141757, DOI: 10.1186/1475-2859-12-16 *
WENGE DONG ET AL.: "SpyTag/Catcher chemistry induces the formation of active inclusion bodies in E. coli", 《INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES》, vol. 199, pages 358 - 371, XP086964465, DOI: 10.1016/j.ijbiomac.2022.01.018 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117264081A (zh) * 2023-11-21 2023-12-22 华南理工大学 一种双肽受体激动剂及其制备方法与应用
CN117866110A (zh) * 2023-12-27 2024-04-12 广东唯泰生物科技有限公司 一种靶向flt-3的第四代嵌合抗原受体及其应用
CN117866110B (zh) * 2023-12-27 2024-06-11 广东唯泰生物科技有限公司 一种靶向flt-3的第四代嵌合抗原受体及其应用

Also Published As

Publication number Publication date
AU2020220637A1 (en) 2021-10-07
JP2022520550A (ja) 2022-03-31
US20220064691A1 (en) 2022-03-03
EP3923968A1 (en) 2021-12-22
CA3130159A1 (en) 2020-08-20
WO2020165425A1 (en) 2020-08-20

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Application publication date: 20210903