CN113329765A - 用于副结核病的免疫原性组合物 - Google Patents

用于副结核病的免疫原性组合物 Download PDF

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Publication number
CN113329765A
CN113329765A CN201980059761.5A CN201980059761A CN113329765A CN 113329765 A CN113329765 A CN 113329765A CN 201980059761 A CN201980059761 A CN 201980059761A CN 113329765 A CN113329765 A CN 113329765A
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CN
China
Prior art keywords
polypeptide
seq
ala
amino acid
leu
Prior art date
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Pending
Application number
CN201980059761.5A
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English (en)
Chinese (zh)
Inventor
约翰·赫尔蒙-泰勒
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HAV Vaccines Ltd
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HAV Vaccines Ltd
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Publication date
Application filed by HAV Vaccines Ltd filed Critical HAV Vaccines Ltd
Publication of CN113329765A publication Critical patent/CN113329765A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201980059761.5A 2018-07-11 2019-07-10 用于副结核病的免疫原性组合物 Pending CN113329765A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1811382.9A GB201811382D0 (en) 2018-07-11 2018-07-11 Vaccine
GB1811382.9 2018-07-11
PCT/GB2019/051933 WO2020012177A1 (en) 2018-07-11 2019-07-10 Immunogenic composition for paratuberculosis

Publications (1)

Publication Number Publication Date
CN113329765A true CN113329765A (zh) 2021-08-31

Family

ID=63273113

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980059761.5A Pending CN113329765A (zh) 2018-07-11 2019-07-10 用于副结核病的免疫原性组合物

Country Status (14)

Country Link
US (2) US12186382B2 (https=)
EP (1) EP3820507A1 (https=)
JP (2) JP2021524485A (https=)
KR (1) KR20210033490A (https=)
CN (1) CN113329765A (https=)
AU (1) AU2019301899A1 (https=)
BR (1) BR112021000312A2 (https=)
CA (1) CA3105763A1 (https=)
GB (1) GB201811382D0 (https=)
IL (1) IL280070B2 (https=)
MA (1) MA53131A (https=)
MX (1) MX2020013924A (https=)
SG (1) SG11202100120TA (https=)
WO (1) WO2020012177A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201700487D0 (en) * 2017-01-11 2017-02-22 Hermon-Taylor John Diagnostic
WO2026041756A1 (en) 2024-08-21 2026-02-26 Hav Vaccines Limited Treatment of crohn's disease by mycobacterium avium subsp. paratuberculosis agent

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007017635A1 (en) * 2005-08-09 2007-02-15 St George's Enterprises Limited Immunogenic constructs
US20070042383A1 (en) * 2002-03-06 2007-02-22 Vivek Kapur Mycobacterial diagnostics
WO2014114812A1 (en) * 2013-01-28 2014-07-31 Danmarks Tekniske Universitet A single or multistage mycobacterium avium subsp. paratuberculosis subunit vaccine

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US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
GB8709803D0 (en) 1987-04-24 1987-05-28 Mcfadden J J Treatment of crohn's disease &c
US5225324A (en) 1987-04-24 1993-07-06 Bioscience International, Inc. Diagnostics for mycobacteria in public health, medical, and veterinary practice
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
CA2489769A1 (en) 1989-03-21 1990-10-04 Philip L. Felgner Expression of exogenous polynucleotide sequences in a vertebrate
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5279833A (en) 1990-04-04 1994-01-18 Yale University Liposomal transfection of nucleic acids into animal cells
US5283185A (en) 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
CA2131620A1 (en) 1992-03-20 1993-09-30 Louis C. Smith A dna transporter system and method of use
WO1993019768A1 (en) 1992-04-03 1993-10-14 The Regents Of The University Of California Self-assembling polynucleotide delivery system
US5651981A (en) 1994-03-29 1997-07-29 Northwestern University Cationic phospholipids for transfection
US5527928A (en) 1994-09-30 1996-06-18 Nantz; Michael H. Cationic transport reagents
GB9526178D0 (en) 1995-12-21 1996-02-21 Taylor John Hermon Novel polynuceotides and polypeptides in pathogenic mycobacteria and their use as diagnostics,vaccines and targets for chemotherapy
GB9806093D0 (en) 1998-03-20 1998-05-20 Taylor John Hermon Diagnostics and vaccines for mycobacterial infections of animals and humans
US8609097B2 (en) 2009-06-10 2013-12-17 Hoffmann-La Roche Inc. Use of an anti-Tau pS422 antibody for the treatment of brain diseases
JP2013500326A (ja) 2009-07-30 2013-01-07 ファイザー バクシーンズ エルエルシー 抗原性タウペプチドおよびその使用
CA2839865A1 (en) 2011-05-19 2012-11-22 University Of Central Florida Research Foundation, Inc. Microbe detection via hybridizing magnetic relaxation nanosensors
WO2014016737A1 (en) 2012-07-24 2014-01-30 Pfizer Inc. Novel chicken monoclonal antibodies against human phosphorylated tau and uses thereof
GB201700487D0 (en) * 2017-01-11 2017-02-22 Hermon-Taylor John Diagnostic

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070042383A1 (en) * 2002-03-06 2007-02-22 Vivek Kapur Mycobacterial diagnostics
WO2007017635A1 (en) * 2005-08-09 2007-02-15 St George's Enterprises Limited Immunogenic constructs
WO2014114812A1 (en) * 2013-01-28 2014-07-31 Danmarks Tekniske Universitet A single or multistage mycobacterium avium subsp. paratuberculosis subunit vaccine

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BULL等: "A Novel Multi-Antigen Virally Vectored Vaccine against Mycobacterium avium Subspecies paratuberculosis", 《PLOS ONE》, 28 November 2007 (2007-11-28), pages 1229 *
GENBANK DATABASE: "Mycobacterium avium subsp. paratuberculosis insertion sequence IS900 transposase gene, partial cds", GENBANK DATABASE, 26 July 2016 (2016-07-26), pages 974347 *
GENBANK DATABASE: "Mycobacterium avium subsp. paratuberculosis strain C4A4 contig_7, whole genome shotgun sequence", GENBANK DATABASE, 6 June 2017 (2017-06-06), pages 01000007 *
PARK等: "Development of vaccines to Mycobacterium avium subsp. paratuberculosis infection", 《CLINICAL AND EXPERIMENTAL VACCINE RESEARCH》, 29 July 2016 (2016-07-29), pages 108 - 116 *
杨益隆: "金黄色葡萄球菌SasA蛋白免疫保护性的研究", 《中国博士学位论文全文数据库（医药卫生科技辑）电子期刊》, 15 November 2016 (2016-11-15), pages 059 - 20 *

Also Published As

Publication number Publication date
MA53131A (fr) 2021-05-19
US12186382B2 (en) 2025-01-07
AU2019301899A1 (en) 2021-01-14
CA3105763A1 (en) 2020-01-16
IL280070B2 (en) 2024-04-01
WO2020012177A1 (en) 2020-01-16
GB201811382D0 (en) 2018-08-29
SG11202100120TA (en) 2021-02-25
JP2021524485A (ja) 2021-09-13
BR112021000312A2 (pt) 2021-04-13
JP2024153666A (ja) 2024-10-29
IL280070B1 (en) 2023-12-01
US20210338791A1 (en) 2021-11-04
IL280070A (en) 2021-03-01
EP3820507A1 (en) 2021-05-19
KR20210033490A (ko) 2021-03-26
US20250152691A1 (en) 2025-05-15
MX2020013924A (es) 2021-03-02

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