CN113317509B - Ketogenic nutritional meal replacement powder and application thereof - Google Patents
Ketogenic nutritional meal replacement powder and application thereof Download PDFInfo
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- CN113317509B CN113317509B CN202110593022.3A CN202110593022A CN113317509B CN 113317509 B CN113317509 B CN 113317509B CN 202110593022 A CN202110593022 A CN 202110593022A CN 113317509 B CN113317509 B CN 113317509B
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A23L33/16—Inorganic salts, minerals or trace elements
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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Abstract
The invention discloses ketogenic nutritional meal replacement powder and application thereof, wherein the ketogenic nutritional meal replacement powder comprises the following components: 45-55 parts of medium-chain triglyceride microcapsule powder, 4-12 parts of lactalbumin, 6-20 parts of soybean protein isolate, 1-3 parts of conjugated linoleic acid microcapsule powder, 1-3 parts of L-carnitine, 0.2-1 part of taurine, 5-18 parts of inulin, 0.5-3.5 parts of konjac powder, 0.1-0.5 part of compound vitamin, 0.5-2 parts of compound mineral substance, 0.05-0.15 part of stevioside, 0.05-0.1 part of mogroside and 1-3 parts of flavor raw material. The formula of the ketogenic diet not only contains high-content fat, but also is compounded with high-content protein, dietary fiber, multiple vitamins and mineral substances, so that satiety can be increased, rapid ketogenic diet weight loss can be facilitated, adverse reactions in the ketogenic diet process can be reduced, and the tolerance of the ketogenic diet can be increased.
Description
Technical Field
The invention relates to the technical field of medical health-care products, in particular to ketogenic nutritional meal replacement powder and application thereof.
Background
The Ketogenic Diet (KD) can limit caloric and fluid intake, has been used for the treatment of epilepsy for centuries, with significant therapeutic effects. In recent years, KD has also been shown to have therapeutic effects in other disease areas, such as chronic diseases like obesity, diabetes, hypertension, cancer, alzheimer's disease, etc. Although KD has a positive effect on the treatment of various diseases, the high proportion of fat intake and the low intake of carbohydrates, proteins and trace elements in the KD process result in unbalanced nutrient absorption, and may cause various adverse reactions such as dizziness, diarrhea, constipation and the like. However, with its widespread use, we must focus on its adverse effects and explore more rational dietary regimens to exert the most beneficial effects of KD. Therefore, the ketogenic meal replacement powder product with scientific proportioning, good edibility and tolerance has important application value and wide market prospect
In the existing ketogenic meal replacement products on the market, the formula composition of part of ketogenic meal replacement food only considers the energy supply proportion of fat, neglects the sources of fat and protein, or lacks other vitamin mineral nutrients, causes nutrition imbalance, and may generate adverse reactions such as hyperlipidemia, selenium deficiency, kidney stone and the like; although some ketogenic products use compound nutrients to achieve nutrition balance, the ketogenic dietary adverse reactions cannot be scientifically proportioned, the taste is poor, and the experience feeling and compliance of users are poor.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides ketogenic nutritional meal replacement powder with good tolerance and application thereof.
In order to achieve the purpose, the invention adopts the technical scheme that:
the invention provides ketogenic nutritional meal replacement powder which comprises the following raw materials in parts by weight: 45-55 parts of medium-chain triglyceride microcapsule powder, 4-12 parts of lactalbumin, 6-20 parts of soybean protein isolate, 1-3 parts of conjugated linoleic acid microcapsule powder, 1-3 parts of L-carnitine, 0.2-1 part of taurine, 5-18 parts of inulin, 0.5-3.5 parts of konjac powder, 0.1-0.5 part of compound vitamin, 0.5-2 parts of compound mineral substance, 0.05-0.15 part of stevioside, 0.05-0.1 part of mogroside and 1-3 parts of flavor raw material.
Preferably, the mass part ratio of the medium chain triglyceride microcapsule powder to the conjugated linoleic acid microcapsule powder is 18-20: 1.
preferably, the mass part ratio of the soybean protein isolate to the whey protein is 1.5-2: 1..
Preferably, the inulin is a short-chain inulin.
Preferably, the mass fraction of medium chain triglycerides in the medium chain triglyceride micro-capsule powder is 70%.
Preferably, the conjugated linoleic acid mass fraction in the conjugated linoleic acid microcapsule powder is 80%.
Preferably, the compound vitamins comprise: vitamin A150-400 mu gRE/g, vitamin D4.1-7.6 mu g/g, vitamin E9.40-23.00 mg alpha-TE/g, vitamin K9.4-40.0 mg alpha-TE/g, vitamin C373.3-560.0 mg/g, vitamin B1.00-10.00 mg/g, vitamin B2 4.00-6.00 mg/g, vitamin B6.00-6.00 zxft 3579/g, vitamin B12.00-4.00 mu g/g, vitamin C273.3-360.0 mg/g, nicotinic acid 25.35-38.00 zxft 3735/g, vitamin B5235-360.00 mu g/g, pantothenic acid 5.27-60.42 zxft 5283 g/g, folic acid 5-60.5 zxft 5283 g, vitamin B5.5-5 zxft 5383 g.
Preferably, the compound mineral comprises: 186-230 mg/g, 156-272-mg/g, 312-580 mg/g calcium, 7.5-10.50 mg/g iron, 8.95-12.45 mg/g zinc, 55.9-68.5 mg/g selenium, 0.32-0.56 mg/g copper.
Preferably, the flavour raw material is selected from: coffee powder, black tea powder, grape fruit powder, mango powder, and strawberry powder.
The invention also provides application of the ketogenic nutritional meal replacement powder in preparation of a weight control nutritional supplement.
Compared with the prior art, the invention has the beneficial effects that: the ketogenic nutritional meal replacement powder is rich in high fat and high protein, and the sources and the mixture ratio of fatty acid and protein are reasonable, so that cardiovascular and cerebrovascular diseases and hypoproteinemia caused by ketogenic diet can be prevented; l-carnitine for promoting fat conversion, taurine for improving immunity and reducing palpitation and inflammatory reaction caused by ketogenic diet, and dietary fiber inulin and konjac flour for improving gastrointestinal function are also added; and vitamins and minerals with specific proportion are added, so that the components have synergistic effect, the satiety is increased, the decomposition and absorption of carbohydrate are controlled, and fat accumulation is avoided. The human body efficacy proves that the weight can be effectively controlled, the adverse reaction in the ketogenic diet process is reduced, the tolerance of the ketogenic diet is increased, and the production and application values are high.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The embodiment provides ketogenic nutritional meal replacement powder which comprises the following raw materials in parts by weight: 50 parts of medium-chain triglyceride micro-capsule powder, 8 parts of whey protein, 16 parts of soybean protein isolate, 2.5 parts of conjugated linoleic acid micro-capsule powder, 1.5 parts of L-carnitine, 0.3 part of taurine, 16 parts of inulin, 2.5 parts of konjaku flour, 0.35 part of compound vitamin, 1.5 parts of compound mineral substance, 0.12 part of stevioside, 0.06 part of mogroside and 1.2 parts of grape fruit powder.
Wherein the mass fraction of medium chain triglyceride in the medium chain triglyceride microcapsule powder is 70%, the mass fraction of conjugated linoleic acid in the conjugated linoleic acid microcapsule powder is 80%, and the inulin is short chain inulin with average polymerization degree DP less than or equal to 9.
The compound vitamins comprise: vitamin A300 mu gRE/g, vitamin D6.5 mu g/g, vitamin E18.50 mg alpha-TE/g, vitamin K25.00 mg alpha-TE/g, vitamin C450.00 mg/g, vitamin B1 8.00 mg/g, vitamin B2 5.00 mg/g, vitamin B6.00 mg/g, vitamin B12.00 mu g/g, vitamin C320.00 mg/g, nicotinic acid 30.00 mg/g, folic acid 450 mu g/g, pantothenic acid 7.50 mg/g, biotin 35.8 mu g/g, choline 62 z 420.5 mg/g.
The compound mineral comprises: phosphorus 200 mg/g, magnesium 265 mg/g, calcium 480 mg/g, iron 8.5 mg/g, zinc 10.5 mg/g, selenium 62.8 mg/g, copper 0.45 mg/g.
Conjugated Linoleic Acid (CLA) is a series of double-bond linoleic acids, and has the effects of scavenging free radicals, enhancing the oxidation resistance and the immunity of a human body, promoting growth and development, regulating the levels of blood cholesterol and triglyceride, preventing atherosclerosis, promoting fat oxidative decomposition, promoting the synthesis of protein of the human body, performing comprehensive benign regulation on the human body and the like. The addition of the conjugated linoleic acid in a proper proportion can prevent cardiovascular and cerebrovascular diseases under a high-fat mode of ketogenic diet, and simultaneously avoid the peroxidation of excessive linoleic acid and the risk of influencing immunity.
The whey protein is called protein king, is a protein extracted from milk, has the characteristics of high nutritional value, easy digestion and absorption, various active ingredients and the like, and is one of the accepted high-quality protein supplements for human bodies. The soybean protein isolate is a high-quality plant protein, the amino acid types are nearly 20, the soybean protein isolate contains essential amino acids for human bodies, the nutrition is rich, cholesterol is not contained, and the whey protein and the soybean protein isolate are reasonably proportioned, so that the simultaneous intake of animal protein and plant protein can be ensured, the protein intake diversity is increased, and the hypoproteinemia caused by ketogenic diet is avoided.
L-carnitine is a kind of amino acid which can promote fat to be converted into energy, can promote fat conversion in a high-fat diet mode, and can avoid hyperlipidemia through synergistic effect.
Taurine is an active substance for regulating normal physiological activities of organisms, and has a wide range of biological functions of diminishing inflammation, easing pain, maintaining the osmotic pressure balance of the organisms, maintaining the normal visual function, regulating the calcium balance of cells, reducing blood sugar, regulating nerve conduction, participating in endocrine activities, regulating lipid digestion and absorption, increasing the heart contractility, improving the immunity of the organisms, enhancing the oxidation resistance of cell membranes, protecting cardiac muscle cells and the like. The reasonable intake can reduce palpitation and inflammatory reaction caused by ketogenic diet.
The short-chain inulin is inulin with average polymerization degree DP less than or equal to 9, and can effectively promote the growth and reproduction of beneficial bacteria-bifidobacterium in human body. The konjac flour is rich in glucomannan, the glucomannan is a natural plant neutral polysaccharide formed by polymerizing glucose and mannose through glycosidic bonds, is an excellent water-soluble dietary fiber, and has more effects of reducing blood fat, reducing blood sugar, reducing blood pressure, losing weight, beautifying, protecting health, relaxing bowels and the like. Short-chain inulin and rhizoma Amorphophalli powder can be added to reduce gastrointestinal dysfunction caused by ketogenic diet.
The compound vitamin and the compound mineral are respectively prepared by mixing multiple vitamins and multiple minerals according to a specific proportion, and can improve the nutrition imbalance generated by a special high-fat diet mode of ketogenic diet. Wherein, aiming at the phenomena of inappetence, dizziness and palpitation easily generated in the early stage of ketogenic dietotherapy, the ketogenic dietotherapy structure is comprehensively considered, and the vitamin B1 and the biotin are obviously and intensively taken. Vitamin B1 is a cofactor of key enzyme of glucose metabolism, has important function in maintaining the balance of oxidative metabolism in brain, and vitamin B1 is also an important bioactive substance for maintaining the normal functions of nerves, heart and digestive system, and the deficiency of vitamin B1 is easy to cause neuritis and inappetence. Biotin plays an important role in biochemical reaction pathways such as fat synthesis and carbohydrate regeneration. The deficiency of vitamin trace elements caused by KD is also extremely harmful to health, researches show that neutropenia and anemia caused by copper deficiency can occur when ketogenic diet is used, and researches show that selenium deficiency exists in 26.9% of patients during KD treatment, so that the ketogenic meal replacement powder is particularly added with trace elements such as copper, iron, selenium and the like to avoid relevant adverse reactions.
Example 2
The present embodiment is different from embodiment 1 in that: the ketogenic nutritional meal replacement powder comprises the following raw materials in parts by weight: 53 parts of medium-chain triglyceride microcapsule powder, 10 parts of whey protein, 15 parts of soybean protein isolate, 2.8 parts of conjugated linoleic acid microcapsule powder, 1.25 parts of L-carnitine, 0.2 part of taurine, 18 parts of inulin, 2 parts of konjac powder, 0.4 part of compound vitamin, 1 part of compound mineral substance, 0.12 part of stevioside, 0.06 part of mogroside and 1.2 parts of mango fruit powder. Example 3
The present embodiment is different from embodiment 1 in that: the ketogenic nutritional meal replacement powder comprises the following raw materials in parts by weight: 48 parts of medium-chain triglyceride microcapsule powder, 12 parts of whey protein, 18 parts of soybean protein isolate, 2.4 parts of conjugated linoleic acid microcapsule powder, 1 part of L-carnitine, 0.4 part of taurine, 16 parts of inulin, 2 parts of konjac powder, 0.25 part of compound vitamin, 0.8 part of compound mineral substance, 0.15 part of stevioside, 0.08 part of mogroside and 1.2 parts of black tea powder.
Example 4
This comparative example differs from example 1 in that: 50 parts of medium-chain triglyceride microcapsule powder and 3 parts of conjugated linoleic acid microcapsule powder in the ketogenic nutritional meal replacement powder; 8 parts of whey protein and 8 parts of soybean protein isolate. The remaining components were the same as in example 1.
Example 5
This comparative example differs from example 1 in that: 53 parts of medium-chain triglyceride microcapsule powder and 2.5 parts of conjugated linoleic acid microcapsule powder in the ketogenic nutritional meal replacement powder; 6 parts of whey protein and 16 parts of soybean protein isolate. The remaining components were the same as in example 1.
Evaluation protocol
1. Experiment for reducing fat of mouse
60 SPF-class mice with similar body weights were used, and the initial body weight was measured to be 30. + -.2 g. After adaptive feeding of 7 d, an obese mouse model was constructed by continuously feeding for two weeks with high-sugar and high-fat feed, and the body weight was measured to be 40 ± 2g. The mice were then randomly divided into 6 groups of 10 mice each, 50% of males and females. One group was fed with normal diet as a control group, the other 5 groups were fed with the same amount of ketogenic nutritional meal replacement powder described in examples 1-5, mouse body weights (g) were measured and recorded weekly, data were processed using SPSS 17.0 statistical software, data were presented as mean, comparisons of differences between groups were performed using one-way anova, and P <0.05 was statistically significant. The measurement results are shown in table 1.
TABLE 1 weight recording results of mice fat-reducing experiments
Note: the difference of lower case letters after the same column data indicates significant difference (P < 0.05)
From the results shown in table 1, it can be seen that the body weight of the mice increased to about 40 ± 2g by constructing an obese mouse model, wherein the average body weight of the mice increased by 2.2g after feeding the mice for 4 weeks due to the ordinary feed fed to the control group. Compared with a control group, the weight of the mice fed with the ketogenic nutritional meal replacement powder of the examples 1-3 is effectively controlled, and the weight of the mice fed with the ketogenic nutritional meal replacement powder of the example 28 d is obviously reduced compared with the control group; after the ketogenic nutritional meal replacement powder described in examples 4-5 is fed, the weight of the mice is reduced, but the weight of the mice is not significantly different from that of the control group, namely, the weight loss effect of the meal replacement powder is influenced by the mass part ratio of the medium chain triglyceride microcapsule powder to the conjugated linoleic acid microcapsule powder and the mass parts of the isolated soy protein and the whey protein in the components. Wherein when the mass part ratio of the medium chain triglyceride microcapsule powder to the conjugated linoleic acid microcapsule powder is 18-20: 1, the mass part ratio of the soybean protein isolate to the whey protein is 1.5-2: 1 hour, the ketogenic nutritional meal replacement powder has the best weight loss effect.
2. Human body efficacy verification
50 volunteers were collected to randomly try the ketogenic nutritional meal replacement powder products of the above examples 1-3 at 40 g/day, and matched with ketogenic diet, and the follow-up visit was 1 month, and finally 34 people adhered to the trial, and 16 people did not adhere to the ketogenic diet or quit in the middle. The weight loss effect and adverse reactions of the 34 consistently tried people were then observed and the results are shown in table 2.
Table 2 human efficacy test results
| Significant weight loss (weight loss greater than 10% of the basic weight) | Gastrointestinal intolerance (constipation, diarrhea, abdominal pain, etc.) | Blood sugar and blood fat abnormality | Dizziness, palpitation and other reactions | |
| Number of people/ratio | 29 persons/85.2% | 2 persons/5.8% | 0 person/0% | 0 person/0% |
The results show that the ketogenic nutritional meal replacement powder product has better weight loss effect, good tolerance after long-term use and no obvious adverse reaction,
by combining the results, the ketogenic nutritional meal replacement powder provided by the invention has an excellent weight loss effect, effectively reduces adverse reactions in the ketogenic diet process, and has good tolerance. The product can be prepared into a weight control nutritional supplement, and has good market nutritional prospect.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are included in the scope of the present invention.
Claims (8)
1. The ketogenic nutritional meal replacement powder is characterized by comprising the following raw materials in parts by weight: 45-55 parts of medium-chain triglyceride microcapsule powder, 4-12 parts of lactalbumin, 6-20 parts of soybean protein isolate, 1-3 parts of conjugated linoleic acid microcapsule powder, 1-3 parts of L-carnitine, 0.2-1 part of taurine, 5-18 parts of inulin, 0.5-3.5 parts of konjac powder, 0.1-0.5 part of compound vitamin, 0.5-2 parts of compound mineral substance, 0.05-0.15 part of stevioside, 0.05-0.1 part of mogroside and 1-3 parts of flavor raw material; the mass part ratio of the medium chain triglyceride microcapsule powder to the conjugated linoleic acid microcapsule powder is 18-20: 1, the mass part ratio of the soybean protein isolate to the whey protein is (1.5-2): 1.
2. the ketogenic nutritional meal replacement powder of claim 1, wherein the inulin is short chain inulin.
3. The ketogenic nutritional meal replacement powder of claim 1, wherein the mass fraction of medium chain triglycerides in the medium chain triglyceride microencapsule powder is 70%.
4. The ketogenic nutritional meal replacement powder according to claim 1, wherein the conjugated linoleic acid microcapsule powder comprises 80% by mass of conjugated linoleic acid.
5. The ketogenic nutritional meal replacement powder of claim 1, wherein the compounded vitamins comprise: vitamin A150-400 mu gRE/g, vitamin D4.1-7.6 mu g/g, vitamin E9.40-23.00 mg alpha-TE/g, vitamin K9.4-40.0 mg alpha-TE/g, vitamin C373.3-560.0 mg/g, vitamin B1.00-10.00 mg/g, vitamin B2 4.00-6.00 mg/g, vitamin B6.00-6.00 zxft 3579/g, vitamin B12.00-4.00 mu g/g, vitamin C273.3-360.0 mg/g, nicotinic acid 25.35-38.00 zxft 3735/g, vitamin B5235-360.00 mu g/g, pantothenic acid 5.27-60.42 zxft 5283 g/g, folic acid 5-60.5 zxft 5283 g, vitamin B5.5-5 zxft 5383 g.
6. The ketogenic nutritional meal replacement powder according to claim 1, wherein the compounded minerals comprise: phosphorus 186-230 mg/g, magnesium 156-272 mg/g, calcium 312-580 mg/g, iron 7.5-10.50 mg/g, zinc 8.95-12.45 mg/g, selenium 55.9-68.5 mg/g, copper 0.32-0.56 mg/g.
7. The ketogenic nutritional meal replacement powder of claim 1, wherein the flavor source is selected from the group consisting of: coffee powder, black tea powder, grape fruit powder, mango powder, and strawberry powder.
8. Use of the ketogenic nutritional meal replacement powder of any one of claims 1-7 in the manufacture of a weight control nutritional supplement.
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| CN107343657B (en) * | 2017-06-05 | 2021-02-26 | 深圳市捷利康生物科技有限公司 | Ketogenic diet formula powder |
| CN110326782A (en) * | 2019-08-16 | 2019-10-15 | 成都三勒浆药业集团四川华美制药有限公司 | A kind of nutritional meal replacement and preparation method thereof with effect of weight reducing |
| CN111084381A (en) * | 2019-12-18 | 2020-05-01 | 东莞自然衡健康科技有限公司 | Ketogenic nutritional meal replacement powder and application |
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