CN113288924A - Traditional Chinese medicine composition and preparation for enhancing immunity - Google Patents
Traditional Chinese medicine composition and preparation for enhancing immunity Download PDFInfo
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- CN113288924A CN113288924A CN202110804718.6A CN202110804718A CN113288924A CN 113288924 A CN113288924 A CN 113288924A CN 202110804718 A CN202110804718 A CN 202110804718A CN 113288924 A CN113288924 A CN 113288924A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the fields of food, health food and traditional Chinese medicine, in particular to a traditional Chinese medicine composition and a preparation with the function of enhancing immunity. The feed is prepared from the following raw materials in parts by weight: 30-80 parts of chicory and 20-70 parts of medicinal cyathula root. The chicory and the radix cyathulae are used together, and the chicory has the effects of invigorating stomach, promoting digestion, promoting urination and reducing swelling; chuan xi Yu has combining action of inducing diuresis and treating stranguria and tonifying liver and kidney. Has the effects of soothing liver, regulating stomach, promoting diuresis and purging turbid. It has no incompatibility and mild property. Strengthen the body resistance and consolidate the constitution, remove dampness and eliminate pathogenic factors, take the root and symptoms into consideration and bring out the best in each other. Meanwhile, chicory polysaccharide, cyathula root polysaccharide and a plurality of active polysaccharides have complementary advantages and synergistic effect, and can effectively play a health-care function of enhancing immunity.
Description
Technical Field
The invention relates to the fields of food, health-care food and traditional Chinese medicine, in particular to a traditional Chinese medicine composition and a preparation with the function of enhancing immunity.
Technical background:
by "immune" is meant protection from disease. The human body has the functions of removing foreign matters and protecting the immune system of the human body, namely the internal disease resistance of the human body, and the Chinese medicine called 'healthy qi' indicates that the 'internal classic' is more than two thousand years ago: "Zhenqiang follows, mental defense, and diseases are all the way around". The term "vital qi" as used herein refers to the body's resistance to pathogenic factors and "vital qi", which can resist (expel or eliminate) pathogenic factors if the body's vital qi is vigorous and there are many pathogenic factors (pathogenic factors), so that the body can be protected from diseases.
TCM emphasizes the leading role of "healthy qi" in pathogenesis. The book of Nei Jing says: the healthy qi is retained in the interior, the pathogenic factors cannot dry out, and the qi must be deficient due to the pathogenic factors. The occurrence, development and outcome of the disease are considered to depend on the elimination of the struggle between healthy qi and pathogenic factors, so that the basic treatment principle of strengthening healthy qi and eliminating pathogenic factors is provided. Practice proves that the guiding idea of emphasizing the struggle between vital qi and diseases has important guiding significance for preventing and treating diseases.
Traditional Chinese medicine is very important for the prevention and early treatment of diseases, and the methods used in the prevention and treatment of diseases are also extremely abundant. The use of modern "immunology" concepts to prevent and treat diseases is common. As early as in jin dynasty puerarin hong (time rear), the following records are recorded: the formula for treating dog bite comprises: the biting dog is killed, and the gall is taken and applied without relapse. Meaning that: after being bitten by mad dog, the rabies can be prevented and treated by taking the bile of the mad dog and applying the bile on the wound, and the example illustrates that ancient people have an immunological thought very early. In the Song dynasty of China, people use the scab of smallpox patients to insufflate healthy children's nose to prevent smallpox. By the eighteenth century or so. The immunity is originally sourced from China since the emergence of the immunity prescription in the first book.
Traditional Chinese medicine not only has effective theory and method for enhancing the immunity of the organism, but also accumulates abundant experience for immune diseases for which no effective treatment method is available so far. The modern immunology theory and technology are used for researching the function of the Chinese herbal medicine on enhancing and regulating the immune function of the body, which is of great significance for clarifying the material basis related to the theory of traditional Chinese medicine, guiding the combination of traditional Chinese medicine and western medicine, preventing and treating common diseases and frequently encountered diseases, and particularly for overcoming malignant tumors.
The immunology research of the traditional Chinese medicine shows that the traditional Chinese medicine can enhance the cellular immunity and the humoral immunity of the organism and promote the physiological functions of lymphocytes, mononuclear macrophages and hematopoietic stem cells.
Chicory (Cichorium intybus L.) also known as endive, French endive, chicory, coffee, etc., is a perennial plant of the family Cichorium, native to Mediterranean, Central Asia and North Africa, and has been cultivated as early as in ancient Rome and Greece. Chicory is cultivated in europe for many years and has been used for many years as a replacement for leafy vegetables, pasture, sugar-making raw materials and coffee. China also has distribution in Xinjiang, Shandong, inner Mongolia and other places. Chicory is a commonly used medicinal material in Uygur and Mongolian nationalities, and the record of the national medicinal material standard Uygur medicine records that the chicory can be used as a medicine and has slightly bitter, salty and cool properties; collected in the Xinjiang Chinese herbal handbook, the Chinese herbal medicine composition is slightly bitter, salty and cool in nature, has the effects of clearing liver and promoting bile flow, invigorating stomach and promoting digestion, and inducing diuresis to reduce edema, and is used for treating diseases such as damp-heat jaundice, stomachache and anorexia, edema and oliguria and the like. Injection of chicory flowers into animals can excite the central nervous system and enhance cardiac activity; the decoction has antibacterial and astringent effects. The root can improve appetite and promote digestion, and the high concentration infusion can improve gastric secretion without enhancing smooth muscle tone. Seeds have non-specific phytohemagglutinin ". The research and report of the chicory medicinal use are also reported abroad. Research shows that the chicory extract is not only an important source of inulin, chicoric acid, fructose and the like, but also has complex components, and polysaccharides, terpenoids (especially sesquiterpenes), flavonoids, phenolic acid compounds, various vitamins, metal elements and other chemical components are separated from the chicory at present. But also has many physiological activities such as immunity enhancement, anti-inflammatory action, uric acid reduction, cholesterol and blood sugar reduction, etc.
Radix Cyathulae is the dried root of Cyathula officinalis Kuan of Amaranthaceae. Mild in nature, sweet and slightly bitter in taste. It enters liver and kidney meridians. Has the functions of dispelling wind, promoting diuresis, dredging meridian and promoting blood circulation. Can be used for treating amenorrhea, abdominal mass, retention of exocytosis, arthralgia, flaccidity of feet, spasm of tendons, stranguria with hematuria and blood, traumatic injury, etc. The research shows that the radix cyathulae contains various medicinal components, such as polysaccharide, saponins, sterones, polysaccharides, betaine and various trace elements. The chemical components of the compound mainly comprise alkaloid and steroid ketone, and the modern pharmacological research shows that the compound has the effects of improving microcirculation, resisting inflammation, resisting fertility, delaying senility, resisting tumor, regulating immunity and the like.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition and a preparation for enhancing immunity
The invention is realized by the following technical scheme: a traditional Chinese medicine composition for enhancing immunity is prepared from the following raw materials in parts by weight: 30-80 parts of chicory and 20-70 parts of medicinal cyathula root.
Further, the feed additive is prepared from the following raw materials in parts by weight: 45-70 parts of chicory and 30-55 parts of medicinal cyathula root.
Further, the feed additive is prepared from the following raw materials in parts by weight: 63 parts of chicory and 37 parts of medicinal cyathula root.
A traditional Chinese medicine preparation for enhancing immunity is prepared from the traditional Chinese medicine composition for enhancing immunity and auxiliary materials, and is prepared into granules, powder, capsules, tablets, pills or liquid preparations.
Further extracting herba Cichorii and radix Cyathulae with water respectively, concentrating the water extract into soft extract, spray drying to obtain paste powder, adding adjuvants, pulverizing, sieving, mixing, and making into granule, powder, capsule, tablet, pill, liquid, etc
Furthermore, the auxiliary materials are one or more of a filling agent, a flavoring agent, a lubricating agent and a disintegrating agent. The invention has the advantages that:
polysaccharides are widely found in animals, plants and microorganisms and are important components of living materials. The plant polysaccharide can improve immunity by increasing macrophage volume. The influence of plant polysaccharide on the phagocytic activity of macrophages has a certain relation with the concentration of the plant polysaccharide, and the plant polysaccharide can promote the phagocytic action of the macrophages within a proper concentration range. The plant polysaccharide can regulate macrophage function by regulating secretion of macrophage cell factor. Plant polysaccharides can influence the function of macrophages by regulating the activity of enzymes in macrophages. The regulation effect of plant polysaccharide on lymphocyte is mainly reflected in the influence on the proliferation capacity, subgroup structure, cytokine secretion and the like. The plant polysaccharide with a certain concentration can promote the proliferation of lymphocytes and improve the subgroup structure of the lymphocytes, thereby regulating the immune function of an organism. The plant polysaccharide can enhance the immune function of the body by promoting the secretion of cell factors. The plant polysaccharide can improve antibody level in animal body serum, and enhance body immunity.
Chicory root is rich in various bioactive substances such as polysaccharide, alkaloid, terpenes and the like, and chicory polysaccharide shows good bioactivity in the aspects of reducing blood sugar, reducing blood fat, resisting oxidation, protecting liver, delaying senescence, improving organism immunity and the like. Chen Li Ge, etc. found that Qikeli polysaccharide (chicory polysaccharide) has antitumor effect, and is mainly characterized in that chicory polysaccharide can obviously inhibit the growth of S180 tumor-bearing mouse tumor, prolong the survival time of S180 tumor-bearing mouse, and inhibit the growth of liver cancer and gastric cancer cell. The development and application of chicory polysaccharide have also become important research directions in the fields of food, medicine, bioengineering and the like.
Cyathula root is used in Chinese medicine for treating various difficult and complicated diseases, and modern medicine also proves that achyranthes root has definite curative effect on many diseases. Achyranthis radix contains various secondary metabolites such as oleanolic acid and its saponin, anthraquinone compounds, flavonoids, alkaloid, ecdysone, etc., all of which have physiological activity. Achyranthes bidentata also contain a high proportion of soluble polysaccharides. The achyranthes bidentata polysaccharide has obvious anticancer, radioresistant, anti-hepatitis and anti-aging effects and has the function of bidirectional immunoregulation. The achyranthes bidentata polysaccharide has the advantages of small molecular weight, good water solubility and low toxicity, can be taken orally and injected, and is a polysaccharide medicament for treatment with a very promising prospect.
The chicory and the radix cyathulae are used together, and the chicory has the effects of invigorating stomach, promoting digestion, promoting urination and reducing swelling; chuan xi Yu has combining action of inducing diuresis and treating stranguria and tonifying liver and kidney. Has the effects of soothing liver, regulating stomach, promoting diuresis and purging turbid. It has no incompatibility and mild property. Strengthen the body resistance and consolidate the constitution, remove dampness and eliminate pathogenic factors, take the root and symptoms into consideration and bring out the best in each other. Meanwhile, chicory polysaccharide, achyranthes polysaccharide and various active polysaccharides have complementary advantages and synergistic effect, and can effectively play a health-care function of enhancing immunity.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention are described below clearly and completely, and it is obvious that the described embodiments are some, not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The traditional Chinese medicine composition for enhancing immunity is prepared from the following raw materials in parts by weight: 60 parts of chicory and 40 parts of medicinal cyathula root, wherein each part is 5 kg.
Example 2:
the traditional Chinese medicine composition for enhancing immunity is prepared from the following raw materials in parts by weight: 65 parts of chicory and 35 parts of medicinal cyathula root;
example 3:
the traditional Chinese medicine composition for enhancing immunity is prepared from the following raw materials in parts by weight: 55 parts of chicory and 45 parts of medicinal cyathula root;
example 4:
the traditional Chinese medicine composition for enhancing immunity is prepared from the following raw materials in parts by weight: 50 parts of chicory and 50 parts of medicinal cyathula root.
Example 5:
a traditional Chinese medicine preparation for enhancing immunity is prepared by respectively extracting the components of the traditional Chinese medicine composition in the embodiments 1 to 4 with water, concentrating the water extract into thick paste, performing spray drying to obtain paste powder, respectively crushing and sieving the paste powder by a 60-100 mesh sieve to obtain extract powder, mixing the extract powder for 40-60 minutes to obtain mixture powder, adding one or more of a filling agent, a flavoring agent, a lubricating agent and a disintegrating agent according to the required dosage form, crushing, sieving, mixing and preparing into granules, powder, capsules, tablets, pills and liquid dosage forms.
Example 6
The traditional Chinese medicine preparation for enhancing immunity is prepared by mixing the traditional Chinese medicine materials of the traditional Chinese medicine composition in the embodiment 1-4, extracting with water, concentrating the water extract into thick paste, spray-drying to obtain paste powder, crushing, sieving by a 60-100 mesh sieve to obtain mixture powder, adding one or more of a filling agent, a flavoring agent, a lubricating agent and a disintegrating agent according to the required dosage form, mixing, and preparing into granules, powder, capsules, tablets, pills and liquid dosage forms according to the conventional preparation process.
Example of effects:
case 1. Lizhi, male, 47 years old, blood routinely measured as 3.32X 10 white blood cell count9Per L, neutrophil count 1.82X 109And L. Example 4 powder made of twotooth achyranthes root with chicory (one packet containing 6g chicory and 3g cyathula root extract) was taken orally 2 times a day, one packet each time without other drug treatment. After 10 days the blood was routinely tested for a white blood cell count of 6.63X 109Per L, neutrophil count 3.77X 109And L. All are within the qualified range, and the subsequent tracking condition is stable.
The above examples are only examples to express the specific embodiments of the present invention, and the description thereof is more specific, but not to be construed as limiting the scope of the application of the present invention; it should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (6)
1. A traditional Chinese medicine composition for enhancing immunity is characterized in that: the feed is prepared from the following raw materials in parts by weight: 30-80 parts of chicory and 20-70 parts of medicinal cyathula root.
2. The traditional Chinese medicine composition for enhancing immunity according to claim 1, which is characterized in that: the material is prepared from the following raw materials in parts by weight: 45-70 parts of chicory and 30-55 parts of medicinal cyathula root.
3. The traditional Chinese medicine composition for enhancing immunity according to claim 2, which is characterized in that: the material is prepared from the following raw materials in parts by weight: 63 parts of chicory and 37 parts of medicinal cyathula root.
4. A traditional Chinese medicine preparation for enhancing immunity is characterized in that: the traditional Chinese medicine composition for enhancing immunity as claimed in any one of claims 1 to 3 and auxiliary materials, and is prepared into granules, powder, capsules, tablets, pills or liquid preparations.
5. The formulation for enhancing immunity according to claim 4, wherein: extracting herba Cichorii and radix Cyathulae with water respectively, concentrating the water extract into soft extract, spray drying to obtain paste powder, adding adjuvants, pulverizing, sieving, mixing, and making into granule, powder, capsule, tablet, pill, or liquid.
6. The traditional Chinese medicine preparation for enhancing immunity according to claim 5, which is characterized in that: the auxiliary materials are one or more of filling agent, flavoring agent, lubricant and disintegrating agent.
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