CN113287706A - Instant health-care granule containing ginseng, oyster and preparation method thereof - Google Patents

Instant health-care granule containing ginseng, oyster and preparation method thereof Download PDF

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CN113287706A
CN113287706A CN202110506830.1A CN202110506830A CN113287706A CN 113287706 A CN113287706 A CN 113287706A CN 202110506830 A CN202110506830 A CN 202110506830A CN 113287706 A CN113287706 A CN 113287706A
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molecular weight
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extraction
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郭建斌
宫大为
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    • A—HUMAN NECESSITIES
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    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
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Abstract

The invention relates to an instant health granule of wood ginseng and oyster and its preparation method, regard diaphragma juglandis, rape bee pollen, red ginseng, radix linderae leaf, Chinese toon, oyster peptide, radix astragali, endothelium corneum gigeriae galli, cortex cinnamomi as the prescription, make up prescription with active substance of medicine, mix with supplementary product, use oyster secondary enzymolysis technology, ethanol extraction technology, water extraction technology and membrane separation concentration technology and vacuum freeze drying process according to the property of the medicinal material, the whole separation concentration process is carried on at room temperature, avoid using the traditional high temperature evaporation concentration method to the loss that active ingredient and active heat-sensitive substance cause in the medicinal material, and can keep the original flavor of the supplies unchanged, not polluted, it is a typical physical separation process, do not need any chemical reagent and additive, make the essence substance separated out and less than 5 ten thousand molecular weight into the high-quality instant health granule, can improve the purity of effective components, and has good therapeutic effect on kidney qi deficiency, spleen qi deficiency, lung qi deficiency, and kidney qi unconsolidation.

Description

Instant health-care granule containing ginseng, oyster and preparation method thereof
Technical Field
The invention relates to a health product and a preparation method thereof, in particular to an instant health granule prepared by a compatibility technology of traditional Chinese medicine health products for warming and tonifying and inducing astringency to tonify kidney and vital essence and a preparation method thereof.
Background
At present, due to various stresses caused by intense market competition and more sub-health groups caused by long-term bad living habits, great harm and burden are caused to the health of the body, the deficiency of the kidney is directly caused, and the unconsolidation of the kidney qi caused by the deficiency of the kidney essence and the yang qi in the kidney is one embodiment of the deficiency.
The insecurity of kidney qi is also called as insecurity of lower-jiao, which is a syndrome manifested by dysfunction of the functions of storing and consolidating due to deficiency of kidney essence and deficiency of kidney yang qi, and is also a reaction of kidney deficiency, and the deficiency of kidney qi can also be caused by the deficiency of spleen qi for a long time, and the deficiency of kidney qi can also aggravate the deficiency of spleen qi. Because the spleen and the stomach are the sources of qi, the kidney is the root of qi, and the deficiency of yang-qi in the kidney can also lead to the deficiency of spleen-qi and lung-qi, which can cause the son and mother to lose the qi of dispersing and descending, thus leading to the deficiency of the upper part and the failure to control, leading to the failure of excessive water to be gasified and to nourish the whole body, and leading to the failure of water to be gasified and to be poured down to the bladder to form frequent urine, and the failure of water to be controlled by spleen-soil, leading to the failure of the bladder to be restrained and taken, leading to the failure of the bladder to be gasified and leading to the occurrence of frequent urination, enuresis, incontinence, and the like. Deficiency of kidney qi can also lead to insufficient brain and marrow, failure of spirit to move, spontaneous urination, and night-time preponderance of yin qi and weakness of yang qi, so deficiency of kidney qi is often seen in frequent urination at night, and deficiency of kidney yang can also lead to unconsolidation of kidney qi. Kidney qi deficiency can cause kidney essence to fail to store essence, so essence can not be fixed, kidney qi deficiency can also cause fecal incontinence, and kidney qi deficiency can also cause insecurity of thoroughfare and conception vessels. The clinical manifestations of kidney qi insecurity are: shortness of breath, mental fatigue, soreness and weakness of waist and knees, tinnitus, deafness, vertigo, amnesia, pale complexion, frequent and clear urination, dribbling urination or enuresis or frequent nocturia or urinary incontinence, spermatorrhea, premature ejaculation, low sexual function, and intestinal deficiency, and even can cause symptoms of kidney failure to receive qi and qi failure to return to original qi, namely yang deficiency failing to transform qi, and asthma aggravated due to cough, dyspnea, failure of continuous movement of qi. Women may have functional uterine bleeding, advanced menstrual cycle, increased menstrual volume, prolonged menstrual period or endless menstrual dripping, even metrorrhagia and metrostaxis, clear and thin leucorrhea such as pregnancy, dripping in the last day, and lumbar plague such as abortion or abortion after pregnancy, parturition, and habitual abortion. Insecurity of thoroughfare and conception vessels is caused by qi deficiency of spleen and kidney, and kidney can not store essence and spleen can not control blood. Chong is blood sea, which governs the uterus and lies in the kidney; the uterus is restricted by the kidney, spleen qi ascends to support blood and qi, and deficiency of original qi can lead to deficiency of spleen and kidney, so that disharmony of thoroughfare and conception vessels can lead to irregular menstruation, abnormal leucorrhea and abnormal control of brain and fetus. The kidney qi deficiency and insecurity of kidney qi are caused by the kidney qi being damaged by the kidney qi exhaustion due to high or weak constitution in the year, congenital deficiency, kidney qi insufficiency, or irregular sexual intercourse or life, long-term staying up, drinking, pungent taste, or long-term illness and strain.
At present, various health care products for tonifying kidney qi are full on the market, and most of the health care products have unsatisfactory effects. On one hand, the prescription combination is not reasonable enough, and on the other hand, the processing technology is not reasonable enough, so that the loss of a plurality of effective active ingredients of the health-care raw materials in the processing process is excessive, and the requirements of consumers on nourishing and health preserving can not be met. At present, no prescription of the instant health-care granule containing the Chinese toon, the rape bee pollen, the red ginseng, the combined spicebush leaf, the Chinese toon, the oyster peptide, the astragalus root, the chicken's gizzard-membrane and the cinnamon is available in the market, and the instant health-care granule containing the Chinese toon, the rape bee pollen, the red ginseng, the combined spicebush leaf, the cedrela sinensis, the oyster peptide, the astragalus root, the chicken's gizzard-membrane and the cinnamon is prepared by extracting, separating ineffective macromolecules by a membrane separation method and then carrying out vacuum freeze-drying on the separated macromolecules.
Disclosure of Invention
Aiming at the defects, the invention provides the instant health-care granule of the wood ginseng and the oyster and the preparation method thereof, wherein the instant health-care granule is prepared by combining the components of diaphragma juglandis, rape bee pollen, red ginseng, lindera aggregate leaf, toona sinensis, oyster peptide, astragalus mongholicus, endothelium corneum gigeriae galli and cinnamon, forming the active ingredients and active substances of the medicines into a formula, matching vitamin C, citric acid, xylitol, aspartame, glutathione and an excipient as auxiliary materials, and processing the granules by adopting an oyster secondary enzymolysis technology, an ethanol extraction technology, a water extraction technology, a membrane separation and concentration technology and a vacuum freeze drying technology according to the properties of medicinal materials.
Aiming at the problems, the technical scheme adopted by the invention is as follows:
an instant health granule containing ginseng, oyster and the like is characterized by comprising the following components in parts by mass: the composition of the instant health-care granules comprises 100 parts of ginseng, wood and oyster: 2.4-5 parts of diaphragma juglandis freeze-dried powder, 2.4-5 parts of rape bee pollen freeze-dried powder, 1.4-3 parts of red ginseng freeze-dried powder, 1.8-3.8 parts of lindera root leaf freeze-dried powder, 1.8-3.8 parts of toona sinensis freeze-dried powder, 1.4-3 parts of oyster peptide freeze-dried powder, 1.8-3.8 parts of astragalus membranaceus freeze-dried powder, 1.2-2.4 parts of endothelium corneum gigeriae galli freeze-dried powder, 0.8-1.6 parts of cinnamon freeze-dried powder, 0.4-1 part of vitamin C, 2-4 parts of citric acid, 0-25 parts of xylitol, 0-0.03 part of aspartame, 0-0.05 part of glutathione and the balance of excipients.
In the scheme, the excipient is beta-cyclodextrin or sucrose;
the preparation method of the instant health-care granule containing the ginseng and the oyster comprises the following steps:
firstly, preparing diaphragma juglandis freeze-dried powder:
1. pretreatment of the diaphragma juglandis:
taking dry diaphragma juglandis, cleaning, removing impurities, airing, and crushing into 20-30-mesh coarse powder for later use;
2. soaking and stirring diaphragma juglandis in ethanol:
putting the crushed heartwood coarse powder into a stainless steel soaking tank, adding 13 times by mass of 60-DEG ethanol, regulating the temperature to 33-35 ℃, carrying out closed soaking for 24-26 hours, starting the machine at intervals of 2 hours, stirring for once, stirring for 28-30 minutes each time, and stirring at the speed of 80 revolutions per minute;
3. extracting with ethanol twice
Putting the soaked and stirred coarse diaphragma juglandis powder and a soaking solution into a multifunctional extraction tank together for carrying out reflux extraction twice, wherein the temperature of the first extraction is 80 +/-1 ℃, the extraction time is 90-93 minutes, recovering ethanol, squeezing to obtain juice, collecting material residues, putting the material residues into the multifunctional extraction tank again, adding 35-degree ethanol which is 12 times of the mass of the coarse diaphragma juglandis powder, carrying out reflux extraction for the second time, the extraction temperature is 80 +/-1 ℃, the extraction time is 90-93 minutes, recovering the ethanol, and squeezing to obtain the juice and waste material residues;
4. filtration
Filtering the extracted diaphragma juglandis extract liquid by using a diatomite filter to obtain diaphragma juglandis filter liquid;
5. membrane separation, concentration, three times
Separating and concentrating the filtered feed liquid of the diaphragma juglandis by using a roll-type ultrafiltration membrane with the molecular weight of 5 ten thousand, a roll-type ultrafiltration membrane with the molecular weight of 3000 and a roll-type nanofiltration membrane with the molecular weight of 100 in turn, and discarding macromolecular impurity liquid with the molecular weight of more than 5 ten thousand, pigment and redundant waste liquid penetrating through the filter membrane with the molecular weight of 100;
6. mixing the concentrated solutions
Mixing the concentrated feed liquid of filter membrane with molecular weight of 3000 and filter membrane with molecular weight of 100, stirring to obtain concentrated feed liquid of diaphragma juglandis with relative density of 1.15-1.25, and refrigerating for use;
7. freeze drying
Feeding the refrigerated concentrated feed liquid of the diaphragma juglandis into a capacity tray of a drying bin of a freeze dryer, setting the temperature of a probe to be-50 ℃ before starting, changing the liquid state into a frozen solid state after 10-12 hours after starting, setting the upper limit of a heating system to be 30 ℃, and obtaining the diaphragma juglandis freeze-dried powder with the water content of less than 5 percent after sublimation and drying for 14-18 hours;
second, preparation of rape bee pollen freeze-dried powder
1. Pretreatment of rape bee pollen
Selecting clean and well-broken rape bee pollen dry powder for later use;
2. extracting with ethanol and stirring for one time
Putting the dry powder of the rape bee pollen with the wall broken into a stainless steel soaking tank, adding 90-degree ethanol which is 15 times of the dry powder of the rape bee pollen by mass, adjusting the temperature to 38-41 ℃, carrying out closed leaching for 24-26 hours, starting the machine at intervals of 2 hours, stirring for once, stirring for 28-30 minutes each time, and stirring at the speed of 120 r/min;
3. centrifuging the ethanol extract
Separating the crude liquid of the rape bee pollen which is extracted and stirred by the ethanol and the leaching liquor for 15 minutes by using a high-speed butterfly centrifuge at the speed of 8000-plus 12000 r/min, separating clear liquid for later use, and collecting material residues for later use;
4. concentrating
Putting the ethanol leaching solution of rape bee pollen separated by a centrifuge into a vacuum concentration tank, regulating the temperature to 43-45 ℃, concentrating under reduced pressure for 2.5-3 hours, recovering ethanol, and collecting the concentrated solution for later use;
5. water leaching and stirring once
Putting the material residues into a stainless steel soaking tank, adding 15 times of drinking water by mass of rape bee pollen dry powder, adjusting the temperature to 38-41 ℃, carrying out closed leaching for 7.5-8 hours, starting up and stirring once every 2 hours, wherein the stirring speed is 120 revolutions per minute;
6. centrifugation of aqueous extract
The rape bee pollen which is extracted and stirred by water and the leaching liquor are separated for 15 minutes by a high-speed butterfly centrifuge at the speed of 8000-12000 r/min, clear liquid is separated for standby, and material residues are discarded;
7. combining filters
Mixing the concentrated solution obtained by soaking in ethanol and the solution obtained by soaking in water and centrifuging, and filtering with diatomite filter;
8. membrane separation, concentration and three times of separation
Sequentially separating and concentrating the filtered rape bee pollen feed liquid by using a roll-type ultrafiltration membrane with the molecular weight of 5 ten thousand, a roll-type ultrafiltration membrane with the molecular weight of 3000 and a roll-type nanofiltration membrane with the molecular weight of 100, and discarding macromolecular impurity liquid with the molecular weight of more than 5 ten thousand, pigment and redundant waste liquid penetrating through the filter membrane with the molecular weight of 100;
9. mixing the concentrated solutions
Mixing the concentrated feed liquid of 3000 molecular weight filter membrane with the concentrated feed liquid of 100 molecular weight filter membrane, stirring to obtain concentrated feed liquid of rape bee pollen with relative density of 1.15-1.25,
refrigerating for later use;
10. freeze drying
Feeding the cold-stored concentrated feed liquid of rape bee pollen into a capacity tray of a drying bin of a freeze dryer, setting the temperature of a probe to be-50 ℃ before starting, changing the liquid state into a frozen solid state after 10-12 hours after starting, setting the upper limit of a heating system to be 30 ℃, and obtaining the freeze-dried powder of the rape bee pollen with the moisture of less than 5 percent after sublimation and drying for 14-18 hours;
preparation of red ginseng freeze-dried powder
1. Pretreatment of red ginseng
Taking dry red ginseng slices, cleaning, removing impurities, airing, and crushing into 20-30 meshes of coarse powder for later use;
2. ethanol soaking and stirring of red ginseng
Putting the ground red ginseng coarse powder into a stainless steel soaking tank, adding 60-degree ethanol in an amount which is 10 times the mass of the red ginseng coarse powder, soaking for 24-26 hours at the normal temperature of 33-35 ℃ in a closed manner, starting the machine at intervals of 2 hours, and stirring for 28-30 minutes every time, wherein the stirring speed is 70 revolutions per minute;
3. extracting with ethanol twice
Putting the soaked and stirred red ginseng coarse powder and a soaking solution into a multifunctional extraction tank together for carrying out first reflux extraction, wherein the extraction temperature is 70 +/-1 ℃, the extraction time is 90-93 minutes, recovering ethanol, squeezing to obtain juice, collecting material residues, putting the squeezed material residues obtained in the first extraction into the multifunctional extraction tank again, adding 60-DEG C ethanol which is 10 times of the mass of the red ginseng coarse powder for carrying out second reflux extraction, the extraction temperature is 70 +/-1 ℃, the extraction time is 90-93 minutes, recovering the ethanol, squeezing to obtain juice, and collecting the material residues for later use;
4. twice with water
Putting red ginseng residue after ethanol extraction into a multifunctional extraction tank, performing reflux extraction twice by using drinking water, adding 10 times of drinking water by mass of red ginseng coarse powder each time, wherein the extraction temperature of the two times is 70 +/-1 ℃, the extraction time of each time is 90-93 minutes, squeezing to obtain juice, and discarding residue;
5. combining filters
Mixing the Ginseng radix Rubri solution extracted with ethanol twice and the Ginseng radix Rubri solution extracted with water twice, and filtering with diatomite filter to obtain Ginseng radix Rubri mixed filtrate;
6. membrane separation, concentration, three times
Separating and concentrating the filtered red ginseng feed liquid by using a roll-type ultrafiltration membrane with the molecular weight of 5 ten thousand, a roll-type ultrafiltration membrane with the molecular weight of 3000 and a roll-type nanofiltration membrane with the molecular weight of 100 in sequence, and discarding macromolecular impurity liquid with the molecular weight of more than 5 ten thousand, pigment and redundant waste liquid penetrating through the filter membrane with the molecular weight of 100;
7. mixing the concentrated solutions
Mixing the concentrated feed liquid of filter membrane with molecular weight of 3000 and filter membrane with molecular weight of 100, stirring to obtain concentrated feed liquid of Ginseng radix Rubri with relative density of 1.15-1.25, and refrigerating;
8. freeze drying
Feeding the refrigerated red ginseng concentrated feed liquid into a capacity tray of a drying bin of a freeze dryer, setting the temperature of a probe to be-50 ℃ before starting up, changing the liquid state into a frozen solid state after 10-12 hours after starting up, setting the upper limit of a heating system to be 30 ℃, and obtaining red ginseng freeze-dried powder with the water content of less than 5 percent after sublimation and drying for 14-18 hours;
preparation of freeze-dried powder of four-nerved spicebush leaf
1. Pretreatment of lindera aggregate leaves
Taking dry lindera aggregate leaves, cleaning, removing impurities, drying in the air, and crushing into 20-30 mesh coarse powder for later use;
2. soaking folium Linderae Strychnifoliae in ethanol under stirring
Putting the lindera aggregate leaf coarse powder into a stainless steel soaking tank, adding 70-degree ethanol in an amount which is 20 times the mass of the lindera aggregate leaf coarse powder, regulating the temperature to 33-35 ℃, carrying out closed soaking for 24-26 hours, starting up the machine every 2 hours, and stirring for 28-30 minutes every time at a stirring speed of 80 revolutions per minute;
3. extracting with ethanol twice
Putting the soaked and stirred crude powder of the lindera aggregate leaves and a soaking solution into a multifunctional extraction tank for reflux extraction, wherein the first extraction time is 90-93 minutes, the extraction temperature is 70 +/-1 ℃, recovering ethanol, pressing to obtain juice, putting material residues into the multifunctional extraction tank, adding 15 times of 50-DEG ethanol by mass of the crude powder of the lindera aggregate leaves, performing second reflux extraction, the extraction time is 90-93 minutes, the extraction temperature is 70 +/-1 ℃, recovering ethanol, pressing to obtain juice, and collecting the material residues for later use;
4. water extraction once
Putting the collected folium Linderae Strychnifoliae residues into a multifunctional extraction tank, adding 15 times of drinking water by mass of folium Linderae Strychnifoliae coarse powder, reflux-extracting for 125 minutes at 70 + -1 deg.C for 120 times, squeezing to obtain juice, and discarding residues;
5. combining filters
Mixing the folium Linderae Strychnifoliae extractive solution extracted with ethanol twice and the folium Linderae Strychnifoliae extractive solution extracted with water once, and filtering with diatomite filter to obtain folium Linderae Strychnifoliae filtrate;
6. membrane separation, concentration, three times
Sequentially separating the filtered lindera aggregata leaf feed liquid by using a roll-type ultrafiltration membrane with the molecular weight of 5 ten thousand, a roll-type ultrafiltration membrane with the molecular weight of 3000 and a roll-type nanofiltration membrane with the molecular weight of 100, concentrating, and discarding macromolecular impurity liquid with the molecular weight of more than 5 ten thousand, pigment and redundant waste liquid penetrating through the filter membrane with the molecular weight of 100;
7. mixing the concentrated solutions
Mixing the concentrated solution of filter membrane with molecular weight of 3000 and filter membrane with molecular weight of 100, stirring to obtain concentrated solution of folium Linderae Strychnifoliae with relative density of 1.15-1.25, and refrigerating;
8. freeze drying
Feeding the refrigerated concentrated folium Linderae Strychnifoliae feed liquid into a capacity tray of a drying bin of a freeze dryer, setting the temperature of a probe to-50 ℃ before starting up, changing the liquid state into a frozen solid state after 10-12 hours after starting up, setting the upper limit of a heating system to 30 ℃, and obtaining the folium Linderae Strychnifoliae freeze-dried powder with the water content of less than 5% after sublimation and drying for 14-18 hours;
preparation of Chinese toon freeze-dried powder
1. Pretreatment of cedrela sinensis
Taking dried Chinese toon, cleaning, removing impurities, airing and crushing into 20-30-mesh coarse powder for later use;
2. ethanol soaking and stirring of cedrela sinensis
Putting the toona sinensis coarse powder into a stainless steel soaking tank, adding 70-degree ethanol 15 times the mass of the toona sinensis coarse powder, regulating the temperature to 33-35 ℃, carrying out closed soaking for 46-48 hours, starting up and stirring once every two hours, wherein the stirring speed is 80 revolutions per minute;
3. extracting with ethanol for four times
Putting the soaked and stirred toona sinensis coarse powder and a soaking solution into a multifunctional extraction tank for reflux extraction, wherein the first extraction time is 90-93 minutes, the extraction temperature is 70 +/-1 ℃, recovering ethanol, putting material residues into the multifunctional extraction tank after squeezing juice, adding 12 times of 70-DEG C ethanol by mass of the toona sinensis coarse powder for second reflux extraction for 90-93 minutes, the extraction temperature is 70 +/-1 ℃, recovering ethanol, putting the material residues into the multifunctional extraction tank after squeezing juice, adding 10 times of 70-DEG C ethanol by mass of the toona sinensis coarse powder for third reflux extraction, the extraction time is 90-93 minutes, the extraction temperature is 70 +/-1 ℃, recovering ethanol, putting the material residues into the multifunctional extraction tank after juice is obtained, adding 8 times of 35-DEG C ethanol by mass of the toona sinensis coarse powder for fourth reflux extraction, extracting for 90-93 min at 70 + -1 deg.C, recovering ethanol, squeezing to obtain juice, and collecting residue;
4. water extraction once
Putting the Chinese toon material residues into a multifunctional extraction tank, adding 25 times of drinking water by mass of the Chinese toon coarse powder for reflux extraction, wherein the extraction time is 2.3-2.5 hours, the extraction temperature is 70 +/-1 ℃, then squeezing juice, and discarding the material residues;
5. combining filters
Mixing the ethanol-extracted toona sinensis liquid of the fourth time and the toona sinensis liquid of the first time, and filtering with a diatomite filter to obtain a toona sinensis filtering liquid;
6. membrane separation, concentration, three times
Separating and concentrating the filtered toona sinensis feed liquid by using a roll-type ultrafiltration membrane with the molecular weight of 5 ten thousand, a roll-type ultrafiltration membrane with the molecular weight of 3000 and a roll-type nanofiltration membrane with the molecular weight of 100 in sequence, and discarding macromolecular impurity liquid with the molecular weight of more than 5 ten thousand, pigment and redundant waste liquid penetrating through the filter membrane with the molecular weight of 100;
7. mixing the concentrated solutions
Mixing the concentrated feed liquid of filter membrane with molecular weight of 3000 and filter membrane with molecular weight of 100, stirring to obtain concentrated feed liquid of Toona sinensis with relative density of 1.15-1.25, and refrigerating for use;
8. freeze drying
Feeding the refrigerated concentrated feed liquid of the cedrela sinensis into a capacity tray of a drying bin of a freeze dryer, setting the temperature of a probe to be-50 ℃ before starting, changing the liquid state into a frozen solid state after 10-12 hours after starting, setting the upper limit of a heating system to be 30 ℃, and obtaining the cedrela sinensis freeze-dried powder with the water content of less than 5% after sublimation and drying for 14-18 hours;
preparation of oyster freeze-dried powder
1. Pretreatment of oysters
Soaking live oysters in water for 46-48 hours, dripping a few drops of sesame oil in the water during soaking, brushing the shell with a brush, taking out oyster meat after the shell is opened, cleaning impurities such as internal organs, putting the oyster meat into a mincing machine to be smashed into pulp after the oyster meat is cleaned, adding water with the mass part being 3 times that of the oyster meat, grinding the oyster meat into fine pulp through a water mill, and refrigerating for later use;
2. enzymolysis
Firstly, preliminary enzymolysis: putting the feed liquid into a reaction kettle, adding bromelain and papain, heating, keeping the temperature at 55 +/-1 ℃, adjusting the pH value to 6, and reacting for 5-5.5 hours;
② secondary enzymolysis
Adding flavor protease into the feed liquid after primary enzymolysis, keeping the temperature at 53 +/-1 ℃, and reacting for the following time: 2.3-2.5 hours;
③ enzyme and sterilization
After the second enzymolysis, heating the feed liquid to 90 +/-1 ℃ in the original reaction kettle, inactivating the enzyme for 18-20 minutes, and sterilizing the feed liquid by a sterilizer at 105 ℃;
3. fishy smell removing device
Cooling the oyster enzymolysis liquid after enzyme deactivation to 43-45 ℃ in an original reaction kettle, adding Angel yeast and cyclodextrin, keeping the temperature at 43-45 ℃ and removing fishy smell for 55-60 minutes;
4. centrifuging and filtering
Adding 10-degree ethanol in an amount which is 3 times the mass of the oyster enzymolysis liquid into the oyster enzymolysis liquid, uniformly stirring, standing for 48-50 hours, centrifuging by using a butterfly high-speed centrifuge, and filtering by using a diatomite filter to obtain oyster peptide feed liquid;
5. membrane separation, concentration, three times
Separating and concentrating the filtered oyster peptide feed liquid by using a roll-type ultrafiltration membrane with the molecular weight of 5 ten thousand, a roll-type ultrafiltration membrane with the molecular weight of 3000 and a roll-type reverse osmosis membrane in sequence, and discarding macromolecular impurity liquid with the molecular weight of more than 5 ten thousand, pigment and redundant wastewater penetrating through the reverse osmosis membrane;
6. mixing the concentrated solutions
Mixing the concentrated feed liquid of the filter membrane with the molecular weight of 3000 and the reverse osmosis filter membrane, stirring to obtain the concentrated feed liquid of the oyster peptide with the relative density of 1.15-1.25, and refrigerating for later use;
7. freeze drying
Directly putting the refrigerated oyster peptide concentrated feed liquid into a capacity tray of a drying bin of a freeze dryer, setting the temperature of a probe to be 50 ℃ below zero before starting up, changing the liquid state into a frozen state after 10 to 12 hours after starting up, setting the upper limit of a heating system to be 30 ℃, and obtaining the oyster peptide freeze-dried powder with the water content of less than 5 percent after sublimation and drying for 14 to 18 hours;
preparation of freeze-dried powder of seven kinds of astragalus root and astragalus root
1. Pretreatment of astragalus membranaceus
Cleaning dried radix astragali, removing impurities, air drying, and pulverizing into 20-30 mesh coarse powder;
2. soaking radix astragali in ethanol, and stirring
Putting the astragalus coarse powder into a stainless steel soaking tank, adding 85-degree ethanol in an amount which is 12 times the mass of the astragalus coarse powder, regulating the temperature to 33-35 ℃, carrying out closed soaking for 24-26 hours, starting the machine at intervals of two hours, and stirring for 28-30 minutes every time, wherein the stirring speed is 70 revolutions per minute;
3. extracting radix astragali with ethanol twice
Putting the soaked astragalus coarse powder and the soak solution into a multifunctional extraction tank for reflux extraction, wherein the extraction time is 90-93 minutes, the extraction temperature is 75 +/-1 ℃, recovering ethanol, pressing to obtain juice, putting the residues into the multifunctional extraction tank again, adding 10 times of 85-DEG C ethanol by mass of the astragalus coarse powder for reflux extraction, the extraction temperature is 75 +/-1 ℃, the extraction time is 90-93 minutes, pressing to obtain juice, and collecting the residues;
4. twice with water
Putting the astragalus mongholicus dregs into a multifunctional extraction tank, adding 15 times of drinking water by mass of astragalus mongholicus coarse powder for reflux extraction, wherein the extraction time is 90-93 minutes, the extraction temperature is 75 +/-1 ℃, putting the dregs into the multifunctional extraction tank after squeezing juice, adding 15 times of drinking water by mass of the astragalus mongholicus coarse powder for secondary reflux extraction, the extraction temperature is 75 +/-1 ℃, the extraction time is 90-93 minutes, squeezing the juice, and discarding the dregs;
5. combining filters
Mixing the radix astragali liquid extracted twice with ethanol and the radix astragali liquid extracted twice with water, and filtering with diatomite filter to obtain radix astragali filtrate;
6. membrane separation, concentration, three times
Sequentially separating and concentrating the filtered astragalus feed liquid by using a roll-type ultrafiltration membrane with the molecular weight of 5 ten thousand, a roll-type ultrafiltration membrane with the molecular weight of 3000 and a roll-type nanofiltration membrane with the molecular weight of 100, and discarding macromolecular impurity liquid with the molecular weight of more than 5 ten thousand, pigment and redundant waste liquid penetrating through the filter membrane with the molecular weight of 100;
7. mixing the concentrated solutions
Mixing the concentrated feed liquid of filter membrane with molecular weight of 3000 and filter membrane with molecular weight of 100, stirring to obtain radix astragali concentrated feed liquid with relative density of 1.15-1.25, and refrigerating for use;
8. freeze drying
Feeding the refrigerated radix astragali concentrated feed liquid into a capacity tray of a drying bin of a freeze dryer, setting the temperature of a probe to-50 ℃ before starting, changing the liquid state into a frozen solid state after 10-12 hours after starting, setting the upper limit of a heating system to 30 ℃, and obtaining radix astragali freeze-dried powder with the water content of less than 5% after sublimation and drying for 14-18 hours;
preparation of endothelium corneum gigeriae galli freeze-dried powder
1. Pretreatment of endothelium corneum gigeriae galli
Cleaning vinegar-fried dried endothelium corneum Gigeriae Galli, removing impurities, air drying, and pulverizing into 60 mesh powder;
2. twice with water
Putting the endothelium corneum gigeriae galli medium powder into a multifunctional extraction tank, adding 10 times by mass of drinking water into the endothelium corneum gigeriae galli medium powder for reflux extraction at the extraction temperature of 80 +/-1 ℃ for 60-63 minutes, pressing to obtain juice, putting the material residues into the multifunctional extraction tank again, adding 8 times by mass of drinking water into the endothelium corneum gigeriae galli medium powder for reflux extraction at the extraction temperature of 80 +/-1 ℃ for 45-48 minutes, pressing to obtain juice, and discarding the material residues;
3. combining filters
Mixing the endothelium corneum Gigeriae Galli extractive solutions extracted with water twice, and filtering with diatomite filter to obtain endothelium corneum Gigeriae Galli filtrate;
4. membrane separation, concentration, three times
Sequentially separating and concentrating the filtered endothelium corneum Gigeriae Galli feed liquid with a roll-type ultrafiltration membrane with molecular weight of 5 ten thousand, a roll-type ultrafiltration membrane with molecular weight of 3000 and a roll-type nanofiltration membrane with molecular weight of 100, and discarding macromolecular impurity liquid with molecular weight of more than 5 ten thousand, pigment and redundant waste liquid passing through the nanofiltration membrane with molecular weight of 100;
5. mixing the concentrated solutions
Mixing the concentrated feed liquid of filter membrane with molecular weight of 3000 and filter membrane with molecular weight of 100, stirring to obtain concentrated feed liquid of endothelium corneum Gigeriae Galli with relative density of 1.15-1.25, and refrigerating;
6. freeze drying
Putting the refrigerated endothelium corneum Gigeriae Galli concentrated feed liquid into a capacity tray of a drying bin of a freeze dryer, setting the temperature of a probe to-50 ℃ before starting up, changing the liquid state into a frozen solid state after 10-12 hours after starting up, setting the upper limit of a heating system to 30 ℃, and obtaining endothelium corneum Gigeriae Galli freeze-dried powder with the water content of less than 5% after sublimation and drying for 14-18 hours;
preparation of freeze-dried powder of' Jiuzui
1. Pretreatment of cinnamon
Selecting dry cinnamon, cleaning, removing impurities, airing, and crushing into coarse powder of 30-40 meshes for later use;
2. extracting cortex Cinnamomi with ethanol twice
Putting the cinnamon coarse powder into a multifunctional extraction tank, adding 80-degree ethanol 15 times the mass of the cinnamon coarse powder for reflux extraction at the extraction temperature of 75 +/-1 ℃ for 155 minutes, recovering the ethanol, putting the material residues into the multifunctional extraction tank again after squeezing juice, adding 30-degree ethanol 15 times the mass of the cinnamon coarse powder for reflux extraction at the extraction temperature of 80 +/-1 ℃ for 125 minutes, recovering the ethanol, squeezing the juice, and discarding the waste residues;
3. combining filters
Mixing the cortex Cinnamomi extractive solutions extracted with ethanol twice, and filtering with diatomite filter to obtain cortex Cinnamomi filtrate;
4. membrane separation, concentration, three times
Separating and concentrating the filtered cinnamon feed liquid by using a roll-type ultrafiltration membrane with the molecular weight of 5 ten thousand, a roll-type ultrafiltration membrane with the molecular weight of 3000 and a roll-type nanofiltration membrane with the molecular weight of 100 in sequence, and discarding macromolecular impurity liquid with the molecular weight of more than 5 ten thousand, pigment and redundant waste liquid penetrating through the filter membrane with the molecular weight of 100;
5. mixing the concentrated solutions
Mixing the filter membrane with molecular weight of 3000 and the concentrated feed liquid with molecular weight of 100, stirring to obtain cortex Cinnamomi concentrated feed liquid with relative density of 1.15-1.25, and refrigerating;
6. freeze drying
Putting the refrigerated cinnamon concentrated solution into a capacity tray of a drying bin of a freeze dryer, setting the temperature of a probe to be 50 ℃ below zero before starting up, changing the liquid state into a frozen solid state after 10-12 hours after starting up, setting the upper limit of a heating system to be 30 ℃, and obtaining the cinnamon freeze-dried powder with the water content of less than 5% after sublimation and drying for 14-18 hours;
blending and making method of instant health granule of ten, mu, Shen and oyster
1. Pulverizing and sieving
Weighing 0.4-1 part of vitamin C, 2-4 parts of citric acid, 0-25 parts of xylitol, 0-0.03 part of aspartame and 0-0.05 part of glutathione according to the mass parts, respectively sieving with a 100-mesh sieve or sieving with a 100-mesh sieve after crushing, then weighing 2.4-5 parts of diaphragma juglandis freeze-dried powder, 2.4-5 parts of rape bee pollen freeze-dried powder, 1.4-3 parts of red ginseng freeze-dried powder, 1.8-3.8 parts of lindera aggregate leaf freeze-dried powder, 1.8-3.8 parts of Chinese toon freeze-dried powder, 1.4-3 parts of oyster peptide freeze-dried powder, 1.8-3.8 parts of astragalus root freeze-dried powder, 1.2-2.4 parts of chicken's gizzard-membrane freeze-dried powder and 0.8-1.6 parts of cinnamon freeze-dried powder, and mixing with the rest of crushed and sieved vitamin C, citric acid, aspartame, glutathione, xylitol and excipient;
2. mixing and granulating
Mixing the above materials, stirring, granulating with a one-step granulator, and grading with 12-14 mesh sieve;
3. package (I)
Packaging the processed granules according to the packaging requirements, and delivering the granules after various indexes are qualified through inspection.
The invention has the beneficial effects that:
the first characteristic of the invention is the rationality of the prescription combination, and the reasons of deficiency of kidney essence and qi, unconsolidation of kidney qi, deficiency of spleen and lung qi and unconsolidation of the sufficient and conception vessels are many, and the comprehensive conditioning is only essential.
The Chinese arborvitae twig and leaf: slightly bitter and astringent, neutral in nature and non-toxic, enters spleen and kidney channels, and has the effects of tonifying kidney, arresting discharge, arresting seminal emission, reducing urination, stopping bleeding, stopping diarrhea, replenishing blood, benefiting qi and the like. Has good therapeutic effects on enuresis, frequent micturition, urgent micturition, spermatorrhea, premature ejaculation, menorrhagia, metrorrhagia, leukorrhagia, intestine slip, and habitual abortion.
The Chinese cabbage bee pollen in the formula has mild nature and sweet taste, belongs to liver, kidney and large intestine channels, can tonify the kidney, consolidate the constitution, strengthen the waist, detoxify and reduce swelling, has anti-inflammation effect, has good effect on treating the kidney failure and the soreness and weakness of the waist and the knees caused by the kidney deficiency, can regulate nerves, regulate endocrine and promote sleep, and particularly has obvious effects on prostatitis, prostatic hyperplasia, frequent micturition, urgent micturition, inexhaustible urine and the like.
The red ginseng in the formula has the functions of greatly invigorating primordial qi, restoring yang and relieving depletion, tonifying spleen and stomach qi, absorbing qi and relieving asthma, tonifying qi and promoting fluid production, calming the nerves and improving intelligence, tonifying qi and supporting yang, tonifying five internal organs and treating five internal diseases and seven injuries, and is used for treating all deficiency symptoms of men and women. Has the effects of nourishing vital gate fire, supporting yang and regulating qi, and has good effects on asthenia, emaciation, heart and kidney yang deficiency, yang qi exhaustion, spleen and stomach qi deficiency, lung and kidney deficiency, inappetence, body fluid deficiency, thirst, heart and kidney imbalance, sexual impotence and cold womb.
The Chinese medicinal materials include lindera leaf: has the effects of dredging the channel of the kidney and the shaoyin, regulating the primordial qi of the spleen and the stomach, warming the middle-jiao, regulating the flow of qi and the like, and especially has obvious effects on frequent micturition, enuresis, abdominal psychroalgia, rheumatism and the like.
Chinese toon in the recipe: has effects of invigorating kidney, arresting spontaneous emission, astringing, arresting discharge, invigorating spleen, promoting appetite, regulating qi-flowing, dispelling pathogenic wind, removing dampness, relieving diarrhea with astringents, stopping bleeding, and consolidating blood, and can be used for treating enuresis, frequent micturition, spermatorrhea, menorrhagia, metrorrhagia, leukorrhagia, chronic diarrhea, puerperal blood flow disorder, and cough due to lung heat.
Oyster peptide in the formula: contains a large amount of amino acids, high-quality protein, taurine, lead, zinc, multivitamin and other nutritional ingredients. The oyster health-care product has the effects of treating deficiency, strengthening liver, detoxifying, nourishing blood, nourishing yin, tonifying kidney, boosting essence, enhancing hematopoietic function, enhancing immunity, resisting fatigue, supplementing physical strength, nourishing heart, nourishing blood, soothing nerves, and astringing and arresting discharge, has certain effects on kidney deficiency and spermatorrhea, deficiency of kidney yin, prostate swelling, dizziness and tinnitus, hand-foot tremor, spontaneous perspiration and night sweat, physical weakness, sexual hypofunction and the like, and changes drug properties after enzymolysis processing, thereby greatly relieving the slippage and also greatly tonifying kidney essence.
In the formula, astragalus root: has effects of invigorating qi, invigorating yang, tonifying deficiency, promoting hematogenesis, invigorating qi, controlling blood, consolidating superficial resistance, arresting sweating, inducing diuresis, relieving swelling, dispelling pathogenic wind, dredging collaterals, and has good therapeutic effects on deficiency of heart and spleen, deficiency of qi, yang deficiency, collapse of middle-warmer energy, deficiency of qi, blood stagnation, and deficiency of lung-qi.
The endothelium corneum Gigeriae Galli of the formula comprises: the Chinese medicinal composition has the advantages of arresting seminal emission, arresting polyuria, arresting enuresis, strengthening and activating the spleen and stomach, arresting discharge, activating the spleen to promote diuresis, removing blood stasis, relieving blood stagnation of the spleen and stomach, and promoting blood circulation to remove blood stasis.
In the formula, cinnamon: has the effects of supplementing fire and supporting yang, guiding fire to the origin, dispelling cold and relieving pain, activating blood and stimulating the menstrual flow, warming yang and regulating qi, and the like, and has good treatment effects on impotence, cold womb, cold pain in heart and abdomen, vomiting and diarrhea due to deficiency cold, cold pain in waist and knees, insufficiency of kidney yang, intolerance of cold and cold limbs, soreness and weakness of waist and knees, thoroughfare and conception vessel deficiency cold, lumbago, impotence and spermatorrhea, frequent micturition, dysmenorrheal, deficiency cold in spleen and stomach, decline of vital gate fire, and the like.
In the compatibility of the formula, the diaphragma juglandis, the rape bee pollen, the lindera aggregate leaf and the Chinese toon have the efficacies of tonifying kidney, spleen and stomach vigor, securing essence and reducing urination, stopping bleeding, securing blood, astringing intestines, preventing metrorrhagia and metrostaxis and leukorrhagia, securing astringency and thoroughfare and conception vessels, and have obvious effects on prostatitis and prostatic hyperplasia. Spleen qi securing water retention, kidney qi securing qi restoring bladder qi, and kidney essence storing. In the formula, the red ginseng, the astragalus and the cinnamon can establish middle-warmer energy, tonify qi, return yang, assist yang to regulate qi, recover yang qi in kidney and promote the normal recovery of the gasification function of bladder.
In the formula, the oyster peptide, the astragalus, the endothelium corneum gigeriae galli and the cinnamon are excellent matching, the oyster peptide can tonify kidney yin, produce sperm and hematopoiesis and tonify deficiency and loss of male and female, but is cool, while the cinnamon can warm middle warmer, warm yang and transform qi, and the astragalus can tonify qi and raise yang, and prevent sinking of middle warmer energy. The endothelium corneum Gigeriae Galli has effects of invigorating spleen and stomach, preventing diarrhea due to spleen deficiency, enhancing spleen and stomach power, and stopping nocturnal emission and reducing urination. The combination of the medicinal materials can promote the recovery of spleen-kidney yang qi, can also tonify deficiency of kidney yin, and can achieve the effects of tonifying yang without dryness, tonifying yin without greasiness, tonifying yin without generation, tonifying yang without transformation, and continuously playing roles of yin and yang with each other.
Therefore, the prescription has good effects on the symptoms of frequent micturition, enuresis, dribbling urination, spermatorrhea, impotence, endless menstruation, metrorrhagia and leukorrhagia, unconsolidation of fetal origin, habitual abortion, chronic diarrhea and chronic dysentery, incontinence of urine and feces, soreness of waist and knees, general weakness and the like caused by kidney essence deficiency and unconsolidation of kidney qi.
The second characteristic of the invention is the rationality of the processing technology, which is divided into two aspects:
one, this scheme has adopted membrane separation concentration technology, its advantage is to go on at normal atmospheric temperature the concentrated process of whole separation, and active ingredient and active material heat-sensitive material and the nutrient composition loss that requires high are few, has avoided the loss that causes active ingredient and active heat-sensitive material in to the medicinal material with traditional high temperature evaporation concentration's method, and membrane separation concentration is going on simultaneously with the purification in addition, can be with the material that a part is invalid to the human body like: the method has the advantages of no need of any chemical reagent or additive, capability of improving the purity of effective components, and incapability of replacing other traditional concentration methods, and can keep the original flavor of materials unchanged, avoid pollution, low energy consumption, high efficiency, low cost, simple process, convenient operation and easy automation production.
The proposal selects the roll-type ultrafiltration membrane with the molecular weight of 5 ten thousand and the roll-type nanofiltration membrane with the molecular weight of 100 because the molecular weight of most effective components in the traditional Chinese medicine is not more than 5 ten thousand. The molecular weight of the Chinese medicinal materials with the minimum effective components is mostly not less than 100.
Secondly, what this scheme adopted is freeze-drying process processing freeze-dried powder, and its characteristics are: compared with other traditional drying methods, the freeze drying method has the advantages that the whole drying process is carried out at low temperature and normal temperature, the freeze drying method has less damage to substances, particularly has extremely small loss of heat-sensitive nutritional factors, can reduce degradation reactions including enzymatic browning and non-enzymatic browning to the maximum extent, retains complete nutritional ingredients and keeps color. Due to the low processing temperature and the rapid sublimation of water, the shelf life of the material is greatly prolonged, and the freeze-dried product is loose and porous and can be completely dissolved in water, which means that the quality of the product is higher. The dried material can maintain the original chemical composition and physical properties. The original color, fragrance, taste and nutrient components of the material are preserved to the maximum extent, the loss of various effective components can be reduced to the minimum extent, and thermosensitive components can be reserved after thermosensitive substances are dried. Because of the operation under vacuum, oxygen is very little, and therefore some easily oxidizable substances are protected. The freeze drying can discharge more than 95-99% of water, so that the product can be stored for a long time without deterioration. The physical structure and the molecular structure of the material are unchanged, so the material does not have the problem of surface hardening. Because the air is isolated, the heat-sensitive substances are effectively inhibited from generating biological, chemical or physical changes. Some of the volatile components of the feed are also lost very little. Many heat-sensitive substances do not denature or become inactive. Therefore, the freeze drying adopted by the scheme is an important link for ensuring the health care curative effect.
In conclusion, the formula of the traditional Chinese medicine is excellent, the conception is ingenious, advanced equipment and advanced processing technology are adopted, the active ingredients in the medicinal materials are greatly improved and completely reserved, the utilization rate of the active ingredients, the medicinal value and the health care value are obviously improved, and the traditional Chinese medicine has the characteristics of high efficacy, easy absorption, quick response and obvious curative effect. Has good curative effect on symptoms of soreness and weakness of waist and knees, lassitude, spermatorrhea, premature ejaculation, frequent micturition, dribbling urination, enuresis, frequent nocturia or urinary incontinence, continuous menstruation, watery vaginal discharge, frequent micturition, fetal movement, intestinal deficiency, slippage, chronic diarrhea, cough, asthma, excessive breathing, and failure of qi supply caused by kidney qi deficiency, spleen qi deficiency, lung qi deficiency, kidney qi weakness or thoroughfare and conception vessel loss. The granule has stable shape, no fishy smell and strange taste, and good taste, and is an ideal high-quality health beverage with high medical care value. The invention is energy-saving and environment-friendly, and provides a new way for the deep processing of the health-care beverage.
Detailed Description
The present invention will be described in further detail with reference to examples.
Example 1
Low-sugar type instant health granule of wood, ginseng and oyster (common public type)
Preparation of freeze-dried powder of rambutan
1.1 pretreatment of the heartwood
Taking dry diaphragma juglandis, removing impurities, cleaning, drying in the air, crushing into 30-mesh coarse powder, and weighing 100 kg for later use.
1.2 ethanol soaking and stirring of diaphragma juglandis
Putting the crushed heartwood coarse powder into a stainless steel stirring tank, adding 1300 kg of 60-degree ethanol, regulating the temperature to 33-35 ℃, sealing and soaking for 24-26 hours, starting the machine at intervals of 2 hours, and stirring for 28-30 minutes every time, wherein the stirring speed is 80 revolutions per minute.
1.3 ethanol extraction twice
1.3.1 first ethanol extraction
Putting the soaked diaphragma juglandis and the soak solution into a multifunctional extraction tank for reflux extraction at the extraction temperature of 80 +/-1 ℃ for 90-93 minutes, recovering ethanol, squeezing to obtain juice, and collecting residues for later use.
1.3.2. Second ethanol extraction
Putting the material residue into a multifunctional extraction tank, adding 1200 kg of 35 deg.C ethanol, reflux-extracting at 80 + -1 deg.C for 90-93 min, recovering ethanol, squeezing to obtain juice, and discarding the material residue.
1.4 Combined filtration
Mixing the core wood material liquid extracted twice with ethanol, and filtering with diatomite filter to obtain core wood filtered material liquid.
1.5 Membrane separation and concentration for three times
1.5.1 first separation
Separating the filtered core-split wood feed liquid by using a roll-type ultrafiltration membrane with the molecular weight of 5 ten thousand, collecting the feed liquid which permeates through the filter membrane for later use, and discarding impurity liquid such as macromolecules and the like which do not permeate through the filter membrane.
1.5.2 second separation, concentration
Separating and concentrating the permeate liquid separated by 5 ten thousand molecular weight for the first time by using a roll type ultrafiltration membrane with 3000 molecular weight, and respectively collecting the concentrated liquid which does not permeate the filter membrane and the liquid which permeates the filter membrane for later use.
1.5.3 third separation, concentration
Separating and concentrating the second pass of 3000 molecular weight separated permeate liquid with a 100 molecular weight rolled nanofiltration membrane, collecting the concentrate liquid which does not permeate the filter membrane for later use, and discarding the waste liquid which permeates the filter membrane.
1.6 combining the concentrated feed liquids
Mixing the concentrated feed liquid obtained by concentrating the filter membrane with molecular weight of 3000 and the filter membrane with molecular weight of 100, stirring to obtain concentrated feed liquid of diaphragma juglandis with relative density of 1.15-1.25, and refrigerating for use.
1.7 Freeze drying
The concentrated feed liquid of the split heartwood is sent into a capacity tray of a drying bin of a freeze dryer (FD-50 type freeze dryer manufactured by Kyoho drying equipment Co., Ltd. in Changzhou city), the temperature of a probe is set to be-50 ℃ before starting, the temperature of a cold trap is also set to be-50 ℃, the liquid state is changed into a frozen solid state after starting for 10-12 hours, when the temperature of the probe reaches-50 ℃, a vacuum system starts to start, when the vacuum degree reaches 2MPa, a heating system starts to sublimate, the upper limit of the heating system is set to be 30 ℃, and after 14-18 hours of sublimation and drying, the split heartwood freeze-dried powder with the moisture content of less than 5% is obtained.
Second, preparation of rape bee pollen freeze-dried powder
2.1 pretreatment of rape bee pollen
Preferably, 100 kg of clean and well-broken rape bee pollen dry product is weighed for standby.
2.2 ethanol extraction and stirring once
Putting the wall-broken rape bee pollen dry powder into a stainless steel soaking tank, adding 1500 kg of 90-degree ethanol, regulating the temperature to 38-41 ℃, sealing and soaking for 24-26 hours, starting the machine at intervals of 2 hours and stirring for 28-30 minutes every time, wherein the stirring speed is 120 revolutions per minute.
2.3 centrifugation of ethanol extract
And (3) separating the crude liquid from the stirred rape bee pollen leached by the ethanol and the leaching liquor by using a high-speed butterfly centrifuge at the speed of 8000-one and 12000 r/min for 15 minutes, separating clear liquid for later use, and collecting material residues for later use.
2.4, concentration
Adding ethanol leaching solution of rape bee pollen separated by centrifuge into vacuum concentrating tank, regulating temperature to 43-45 deg.C, concentrating under reduced pressure for 2.5-3 hr, recovering ethanol, and collecting concentrated solution.
2.5, water leaching and stirring once
Putting the material slag into a stainless steel soaking tank, adding 1500 kg of drinking water, adjusting the temperature to 38-41 ℃, sealing and soaking for 7.5-8 hours, starting the machine for stirring once every 2 hours, and stirring for 28-30 minutes every time at the stirring speed of 120 revolutions per minute.
2.6 centrifugation of the aqueous extract
The rape bee pollen which is extracted and stirred by water and the leaching liquor are separated for 15 minutes by a high-speed butterfly centrifuge at the speed of 8000-12000 r/min, clear liquid is separated for standby, and material residues are discarded.
2.7, combining and filtering
Mixing the concentrated ethanol extractive solution and the centrifuged solution, and filtering with diatomite filter.
2.8, membrane separation, concentration and total separation for three times
2.8.1 first separation
Separating the filtered rape bee pollen liquid by using a rolling type ultrafiltration membrane with the molecular weight of 5 ten thousand, collecting the liquid which permeates through the filter membrane for later use, and discarding impurity liquid such as macromolecules and the like which do not permeate through the filter membrane.
2.8.2 second separation, concentration
Separating and concentrating the permeate liquid separated by using 5 ten thousand molecular weight for the first time by using a roll type ultrafiltration membrane with the molecular weight of 3000, and then respectively collecting the feed liquid permeating the filter membrane and the concentrated feed liquid not permeating the filter membrane for later use.
2.8.3, third separation, concentration
Separating and concentrating the permeate liquid separated by 3000 molecular weight for the second time by using a rolled nanofiltration membrane with the molecular weight of 100, collecting the concentrated feed liquid which does not permeate the filter membrane for later use, and discarding the waste liquid which permeates the filter membrane.
2.8.4 mixing the concentrated solutions
Mixing the concentrated feed liquid of 3000 molecular weight filter membrane and the concentrated feed liquid of 100 molecular weight filter membrane, stirring to obtain concentrated feed liquid of rape bee pollen with relative density of 1.15-1.25, and refrigerating for use.
2.9, Freeze drying
Feeding the cold-stored concentrated feed liquid of rape bee pollen into a capacity tray of a drying bin of a freeze dryer (FD-50 type freeze dryer manufactured by Changzhou Pan Feng drying equipment Co., Ltd.), setting the temperature of a probe to-50 ℃ before starting, setting the temperature of a cold trap to-50 ℃, changing the liquid state into a frozen solid state after 10-12 hours after starting, starting a vacuum system when the temperature of the probe reaches-50 ℃, starting a heating system for sublimation when the vacuum degree reaches 2MPa, setting the upper limit of the heating system to be 30 ℃, and sublimating for 14-18 hours,
Drying to obtain rape bee pollen freeze-dried powder with the water content less than 5%.
Preparation of red ginseng freeze-dried powder
3.1 pretreatment of Red Ginseng
Taking dry red ginseng slices, cleaning and removing impurities, drying in the air, crushing into 20-30 meshes of coarse powder, and weighing 100 kg for later use.
3.2 ethanol soaking and stirring of Ginseng radix Rubri
Putting the red ginseng coarse powder into a stainless steel soaking tank, adding 1000 kilograms of 60-degree ethanol, regulating the temperature to 33-35 ℃, sealing and soaking for 24-26 hours, starting the machine at intervals of 2 hours, and stirring for 28-30 minutes every time, wherein the stirring speed is 70 revolutions per minute.
3.3 ethanol extraction twice
First extraction
Putting the soaked red ginseng and the soak solution into a multifunctional extraction tank for reflux extraction at the extraction temperature of 70 +/-1 ℃ for 90-93 minutes, recovering ethanol, squeezing to obtain juice, and collecting residues for later use.
Second extraction
Putting the residue after the first ethanol extraction into a multifunctional extraction tank, adding 1000 kg of 60-degree ethanol for reflux extraction at 70 + -1 deg.C for 90-93 min, recovering ethanol, squeezing to obtain juice, and collecting residue.
3.4 Water extraction twice
First water extraction
Putting red ginseng dregs after ethanol extraction and pressing into a multifunctional extraction tank, adding 1000 kg of drinking water for reflux extraction at the extraction temperature of 70 +/-1 ℃ for 90-93 minutes, then pressing to obtain juice, and collecting dregs for later use.
Second water extraction
Putting the material residues into a multifunctional extraction tank, adding 1000 kg of drinking water for reflux extraction at the extraction temperature of 70 +/-1 ℃ for 90-93 minutes, squeezing to obtain juice, and discarding the material residues.
3.5 Combined filtration
Mixing the two ethanol-extracted Ginseng radix Rubri solutions and the two water-extracted Ginseng radix Rubri solutions, and filtering with diatomite filter to obtain Ginseng radix Rubri filtrate.
3.6 Membrane separation, concentration, three steps
First separation
Separating the filtered red ginseng liquid by using a 5 ten thousand molecular weight roll-type ultrafiltration membrane, collecting the liquid which permeates through the filter membrane for later use, and discarding the macromolecular impurity liquid which does not permeate through the filter membrane.
Second separating and concentrating
Separating and concentrating the permeate liquid separated by 5 ten thousand molecular weight for the first time by using a roll type ultrafiltration membrane with 3000 molecular weight, and respectively collecting the concentrated liquid which does not permeate the filter membrane and the liquid which permeates the filter membrane for later use.
Third separating and concentrating
Separating and concentrating the second 3000 molecular weight separated permeate liquid with a 100 molecular weight rolled nanofiltration membrane, collecting the concentrate liquid which does not permeate the filter membrane for later use, and discarding the waste liquid which permeates the filter membrane.
3.7 combining the concentrated feed liquids
Mixing the concentrated solutions obtained by concentrating the filter membranes with molecular weight of 3000 and 100, stirring to obtain concentrated solution with relative density of 1.15-1.25, and refrigerating.
3.8 Freeze drying
Putting the refrigerated red ginseng concentrated solution into a capacity tray of a drying bin of a freeze dryer (FD-50 type freeze dryer manufactured by Renzhou Torpeng drying equipment Co., Ltd.), setting the temperature of a probe to-50 ℃ before starting, setting the temperature of a cold trap to-50 ℃, changing the liquid state into a frozen solid state after 10-12 hours after starting, starting a vacuum system when the temperature of the probe reaches-50 ℃, starting a heating system for sublimation after the vacuum degree reaches 2KPa, setting the upper limit of the heating system to 30 ℃, and obtaining the red ginseng freeze-dried powder with the moisture of less than 5 percent after sublimation and drying for 14-18 hours.
Preparation of freeze-dried powder of four-nerved spicebush leaf
4.1 pretreatment of Linderae radix leaves
Taking dry lindera aggregate leaves, removing impurities, cleaning, drying in the air, crushing into coarse powder of 30 meshes, and weighing 100 kg for later use.
4.2. Soaking folium Linderae Strychnifoliae in ethanol under stirring
Putting the crushed coarse powder of the lindera aggregate leaves into a stainless steel soaking tank, adding 2000 kg of 70-degree ethanol, regulating the temperature to 33-35 ℃, carrying out closed soaking for 24-26 hours, starting the machine at intervals of 2 hours, and stirring for 28-30 minutes every time at the stirring speed of 80 revolutions per minute.
4.3 ethanol extraction twice
4.3.1 first ethanol extraction
Putting the soaked and stirred crude powder of the lindera aggregate leaf and the soaking solution into a multifunctional extraction tank for reflux extraction at the extraction temperature of 70 +/-1 ℃ for 90-93 minutes, recovering ethanol, squeezing to obtain juice, and collecting residues for later use.
4.3.2 second ethanol extraction
Putting the material residue after the first extraction into a multifunctional extraction tank, adding 1500 kg of 50-degree ethanol for reflux extraction at the extraction temperature of 70 +/-1 ℃ for 90-93 minutes, recovering ethanol, squeezing to obtain juice, and collecting the material residue for later use.
4.4 Water extraction Once
Putting the material slag into a multifunctional extraction tank, adding 1500 kg of drinking water for reflux extraction at the extraction temperature of 70 +/-1 ℃ for 125 minutes, squeezing juice and discarding the material slag.
4.5: combining filters
Mixing the two ethanol extractive solutions and the one water extractive solution, and filtering with diatomite filter to obtain folium Linderae Strychnifoliae filtrate.
4.6 Membrane separation, concentration, three times in total
4.6.1 first separation
Separating the filtered folium Linderae Strychnifoliae material liquid with a 5-ten-thousand molecular weight roll-type ultrafiltration membrane, collecting the material liquid penetrating through the filter membrane for use, and discarding the macromolecular impurity liquid not penetrating through the filter membrane.
4.6.2 second separation, concentration
Separating and concentrating the permeating material liquid separated by the 5 ten thousand molecular weight filter membrane for the first time by using a roll type ultrafiltration membrane with the molecular weight of 3000, and respectively collecting the concentrated material liquid which does not permeate the filter membrane and the material liquid which permeates the filter membrane for later use.
4.6.3 separating and concentrating for the third time
Separating and concentrating the second time with 3000 molecular weight separated permeate liquid with a 100 molecular weight rolled nanofiltration membrane, collecting the concentrate liquid which does not permeate the filter membrane for later use, and discarding the permeate waste liquid which permeates the filter membrane.
4.7 combining the concentrated feed solutions
Mixing the concentrated solutions obtained by concentrating the filter membranes with molecular weight of 3000 and 100, stirring to obtain concentrated solution of folium Linderae Strychnifoliae with relative density of 1.15-1.25, and refrigerating.
4.8 Freeze drying
Sending the refrigerated concentrated feed liquid of the lindera aggregata leaves into a capacity tray of a drying bin of a freeze dryer (FD-50 type freeze dryer manufactured by Renzhou Torpedo drying equipment Co., Ltd.), setting the temperature of a probe to-50 ℃ before starting, setting the temperature of a cold trap to-50 ℃, changing the liquid state into a frozen solid state after 10-12 hours after starting, starting a vacuum system when the temperature of the probe reaches-50 ℃, starting a heating system for sublimation after the vacuum degree reaches 2MPa, setting the upper limit of the heating system to 30 ℃, and obtaining the lindera aggregata leaves freeze-dried powder with the moisture of less than 5 percent after sublimation and drying for 14-18 hours.
Preparation of Chinese toon freeze-dried powder
5.1 pretreatment of Toona sinensis
Taking dried cedrela sinensis, removing impurities, cleaning, drying in the air, crushing into 20-30 meshes of coarse powder, and weighing 100 kg for later use.
5.2 ethanol soaking and stirring of Toona sinensis
Putting the crushed Chinese toon coarse powder into a stainless steel soaking tank, adding 1500 kilograms of 70-degree ethanol, regulating the temperature to 33-35 ℃, carrying out closed soaking for 46-48 hours, starting the machine at intervals of 2 hours, and stirring for 28-30 minutes every time, wherein the stirring speed is 80 revolutions per minute.
5.3 ethanol extraction four times
5.3.1 first ethanol extraction
Putting the stirred and soaked toona sinensis coarse powder and the soaking solution into a multifunctional extraction tank for reflux extraction at the extraction temperature of 70 +/-1 ℃ for 90-93 minutes, recovering ethanol, squeezing to obtain juice, and collecting residues.
5.3.2 second ethanol extraction
Putting the material residue collected after the first extraction into a multifunctional extraction tank, adding 1200 kg of 70-degree ethanol for reflux extraction at the extraction temperature of 70 +/-1 ℃ for 90-93 minutes, recovering ethanol, squeezing to obtain juice, and collecting the material residue.
5.3.3 third ethanol extraction
And putting the material residue collected after the second extraction into a multifunctional extraction tank, adding 1000 kg of 70-degree ethanol for reflux extraction at the extraction temperature of 70 +/-1 ℃ for 90-93 minutes, recovering the ethanol, squeezing to obtain juice, and collecting the material residue.
5.3.4 fourth ethanol extraction
And putting the material residue collected after the third extraction into a multifunctional extraction tank, adding 800 kg of 35-degree ethanol for reflux extraction at the extraction temperature of 70 +/-1 ℃ for 90-93 minutes, recovering the ethanol, squeezing juice, and collecting the material residue for later use.
5.4 Water extraction Once
And putting the material residue which is collected after the fourth extraction with ethanol into a multifunctional extraction tank, adding 2500 kg of drinking water for reflux extraction at the extraction temperature of 70 +/-1 ℃ for 2.3-2.5 hours, squeezing juice, and discarding the material residue.
5.5 Combined filtration
Mixing the ethanol-extracted Chinese toon feed liquid of the fourth time and the water-extracted Chinese toon feed liquid of the first time, and filtering with a diatomite filter to obtain the Chinese toon filter feed liquid.
5.6 Membrane separation, concentration, three times in total
5.6.1 first separation
Separating the filtered toona sinensis feed liquid by using a 5-ten-thousand-molecular-weight roll-type ultrafiltration membrane, collecting the feed liquid penetrating through the filter membrane for later use, and discarding the invalid macromolecular impurity liquid which does not penetrate through the filter membrane.
5.6.2 second separation, concentration
Separating and concentrating the permeate liquid separated by the 5 ten thousand molecular weight filter membrane for the first time by using a roll type ultrafiltration membrane with the molecular weight of 3000, and respectively collecting the concentrated feed liquid which does not permeate the filter membrane and the feed liquid which permeates the filter membrane for later use.
5.6.3 separating and concentrating for the third time
Separating and concentrating the filtrate separated by the filter membrane with molecular weight of 3000 for the second time by using a rolled nanofiltration membrane with molecular weight of 100, collecting the concentrated filtrate which does not permeate the filter membrane for later use, and discarding the waste liquid permeating the filter membrane.
5.7 combining the concentrated feed liquids
Mixing the concentrated solutions obtained by concentrating the filter membranes with molecular weight of 3000 and 100, stirring to obtain concentrated solution with relative density of 1.15-1.25, and refrigerating.
5.8 Freeze drying
Sending the refrigerated toona sinensis concentrated feed liquid into a capacity tray of a drying bin of a freeze dryer (FD-50 type freeze dryer manufactured by Changzhou Pantofeng drying equipment Co., Ltd.), setting the temperature of a probe to-50 ℃ before starting, setting the temperature of a cold trap to-50 ℃, changing the liquid state into a frozen solid state after starting for 10-12 hours, starting a vacuum system when the temperature of the probe reaches-50 ℃, starting a heating system for sublimation when the vacuum degree reaches 2MPa, setting the upper limit of the heating system to be 30 ℃, and obtaining the toona sinensis freeze-dried powder with the moisture of less than 5 percent after sublimation and drying for 14-18 hours.
Preparation of oyster peptide freeze-dried powder
6.1 Pre-treatment of oysters
Firstly, soaking live oysters in clean water for 46-48 hours, dripping a few drops of sesame oil in the water during soaking, then brushing the shells clean by a brush, taking out oyster meat after the shells are opened, cleaning impurities such as internal organs and the like, weighing 100 kilograms of oyster meat after the oyster meat is cleaned, putting the oyster meat into a blender to be smashed into pulp, adding 300 kilograms of water, grinding the pulp into fine pulp by a water mill, and refrigerating for later use.
6.2 enzymatic hydrolysis
6.2.1 preliminary enzymolysis
Adding the feed liquid into a reaction kettle, adding 0.2% of bromelain (produced by Nanning Dong Henghua biological science and technology Limited, with enzyme activity of 60 ten thousand units) and 0.3% of papain (produced by Nanning Dong Henghua biological science and technology Limited, with enzyme activity of 60 ten thousand units) and 0.1% of sodium phytate, heating and maintaining the temperature at 55 + -1 deg.C, adjusting pH to 6, and reacting for 5-5.5 hr.
6.2.2 Secondary enzymolysis
Adding flavourzyme (50 ten thousand units of enzyme activity produced by Sierra vitamin biotechnology limited) 0.3% of the weight of the oyster meat into the feed liquid after the primary enzymolysis, keeping the temperature at 53 +/-1 ℃, and reacting for 2.3-2.5 hours.
6.2.3 enzyme and Sterilization
After the second enzymolysis, heating the oyster enzymolysis liquid to 90 plus or minus 1 ℃ in the original reaction kettle, inactivating the enzyme for 18-20 minutes, and sterilizing the feed liquid by a sterilizer at 105 ℃ after inactivating the enzyme.
6.3 removing fishy smell
Cooling the oyster enzymolysis liquid after enzyme deactivation to 43-45 ℃ in an original reaction kettle, adding Angel yeast accounting for 0.75 percent of the weight of oyster meat and cyclodextrin accounting for 0.5 percent of the weight of the oyster meat, keeping the temperature at 43-45 ℃ and removing fishy smell for 55-60 minutes.
6.4 centrifugation and filtration
Adding 1200 kg of 10-degree ethanol into the oyster enzymolysis liquid, stirring uniformly, standing for 48-50 hours, centrifuging by using a butterfly high-speed centrifuge, and filtering by using a diatomite filter to obtain the oyster peptide feed liquid.
6.5 Membrane separation, concentration, three times in total
First separation
Separating the filtered oyster peptide feed liquid by using a roll-type ultrafiltration membrane with the molecular weight of 5 ten thousand, collecting the feed liquid penetrating through the filter membrane for later use, and discarding the macromolecular impurity liquid which does not penetrate through the filter membrane.
Second separating and concentrating
Separating and concentrating the permeate liquid separated by 5 ten thousand molecular weight for the first time by using a roll type ultrafiltration membrane with 3000 molecular weight, and respectively collecting the concentrated liquid which does not permeate the filter membrane and the liquid which permeates the filter membrane for later use.
Third separating and concentrating
Separating and concentrating the permeable material liquid separated by 3000 molecular weight for the second time by using a rolled reverse osmosis membrane, increasing the temperature of the material liquid to 33-35 ℃, keeping the temperature, adjusting the water inlet pressure to 17-17.5MPa, and keeping the pressure difference between the concentrated water pressure and the water inlet pressure to be 1-1.5MPa, then collecting the concentrated material liquid which does not permeate the filter membrane for later use, and discarding the waste water which permeates the filter membrane.
6.6 combining the concentrated feed solutions
Mixing the concentrated feed liquid obtained by concentrating the filter membrane with molecular weight of 3000 and the reverse osmosis filter membrane, stirring to obtain concentrated feed liquid of oyster peptide with relative density of 1.15-1.25, and refrigerating for use.
6.7 Freeze drying
Directly putting the refrigerated oyster peptide concentrated feed liquid into a capacity tray of a drying bin of a freeze dryer (FD-50 type freeze dryer manufactured by Changzhou Pantafeng drying equipment Co., Ltd.), setting the temperature of a probe to-50 ℃ before starting, setting the temperature of a cold trap to-50 ℃, changing the liquid state into a frozen solid state after starting for 14-18 hours, starting a vacuum system when the temperature of the probe reaches-50 ℃, starting a heating system for sublimation when the vacuum degree reaches 2MPa, setting the upper limit of the heating system to be 30 ℃, and obtaining the oyster peptide freeze-dried powder with the moisture of less than 5 percent after sublimation and drying for 14-18 hours.
Preparation of freeze-dried powder of seven kinds of astragalus root and astragalus root
7.1: pretreatment of astragalus membranaceus
Taking dry astragalus, removing impurities, cleaning, drying in the air, crushing into 20-30 meshes of coarse powder, and weighing 100 kg for later use.
7.2 ethanol soaking and stirring of Astragalus membranaceus
Putting the crushed astragalus coarse powder into a stainless steel soaking tank, adding 1200 kg of 85-degree ethanol, regulating the temperature to 33-35 ℃, carrying out closed soaking for 24-26 hours, starting the machine at two-hour intervals, and stirring for 28-30 minutes every time, wherein the stirring speed is 70 revolutions per minute.
7.3 ethanol extraction of Astragalus membranaceus twice
7.3.1 first ethanol extraction
Putting the soaked and stirred astragalus coarse powder and the soaking solution into a multifunctional extraction tank for reflux extraction at the extraction temperature of 75 +/-1 ℃ for 90-93 minutes, recovering ethanol, squeezing to obtain juice, and collecting residues.
7.3.2 second ethanol extraction
Putting the residue obtained after the first ethanol extraction into a multifunctional extraction tank, adding 1000 kg of 85 deg.C ethanol, reflux-extracting at 75 + -1 deg.C for 90-93 min, recovering ethanol, squeezing to obtain juice, and collecting residue.
7.4 Water extraction of Astragalus membranaceus twice
7.4.1 first Water extraction
Putting the material residue after ethanol extraction into a multifunctional extraction tank, adding 1500 kg of drinking water for reflux extraction at 75 +/-1 ℃ for 90-93 minutes, squeezing to obtain juice, and collecting the material residue.
7.4.2 second Water extraction
Putting the material residue collected after the first water extraction into a multifunctional extraction tank, adding 1500 kg of drinking water for reflux extraction at the extraction temperature of 75 +/-1 ℃ for 90-93 minutes, squeezing juice, and discarding the material residue.
7.5 Combined filtration
Mixing the radix astragali liquid extracted twice with ethanol and the radix astragali liquid extracted twice with water, and filtering with diatomite filter to obtain radix astragali filtrate.
7.6 Membrane separation, concentration, three times in total
7.6.1 first separation
Separating the filtered astragalus membranaceus feed liquid by using a 5-ten-thousand-molecular-weight roll-type ultrafiltration membrane, collecting the feed liquid penetrating through the filter membrane for later use, and discarding the macromolecular impurity liquid which does not penetrate through the filter membrane.
7.6.2 separating and concentrating for the second time
Separating and concentrating the permeating material liquid separated by the 5 ten thousand molecular weight filter membrane for the first time by using a roll type ultrafiltration membrane with the molecular weight of 3000, and respectively collecting the concentrated material liquid which does not permeate the filter membrane and the material liquid which permeates the filter membrane for later use.
7.6.3 third separation and concentration
Separating and concentrating the permeate liquid separated by the filter membrane with the molecular weight of 3000 for the second time by using a roll-type nanofiltration membrane with the molecular weight of 100, collecting the concentrated feed liquid which does not permeate the filter membrane for later use, and discarding the waste liquid which permeates the filter membrane.
7.7 combining the concentrated feed solution
Mixing the concentrated feed liquid of 3000 molecular weight filter membrane and 100 molecular weight filter membrane, stirring well to obtain radix astragali concentrated feed liquid with relative density of 1.15-1.25, and refrigerating for use.
7.8 Freeze drying
Feeding the refrigerated radix astragali concentrated feed liquid into a capacity tray of a drying bin of a freeze dryer (FD-50 type freeze dryer manufactured by Kyoho drying equipment Co., Ltd., Changzhou), setting the temperature of a probe to-50 ℃ before starting, setting the temperature of a cold trap to-50 ℃, changing the liquid state into a frozen solid state after 10-12 hours after starting, starting a vacuum system when the temperature of the probe reaches-50 ℃, starting the heating system for sublimation when the vacuum degree reaches 2MPa, setting the upper limit of the heating system to 30 ℃, and obtaining radix astragali freeze-dried powder with the moisture of less than 5 percent after 14-18 hours of sublimation and drying.
Eighthly, preparing the chicken's gizzard-membrane freeze-dried powder:
8.1 pretreatment of endothelium corneum Gigeriae Galli
Cleaning the dried endothelium corneum Gigeriae Galli processed with vinegar, removing impurities, air drying, pulverizing into 60 mesh powder, and weighing 100 kg.
8.2 Water extraction twice
8.2.1 first Water extraction
Putting the endothelium corneum Gigeriae Galli powder into a multifunctional extraction tank, adding 1000 kg of drinking water, reflux-extracting at 80 + -1 deg.C for 60-63 min, squeezing to obtain juice, and collecting residue.
8.2.2 second Water extraction
Putting the collected endothelium corneum Gigeriae Galli residue into a multifunctional extraction tank, adding 800 kg of drinking water, reflux-extracting at 80 + -1 deg.C for 45-48 min, squeezing to obtain juice, and discarding residue.
8.3 Combined filtration
Mixing the endothelium corneum Gigeriae Galli extractive solutions extracted with water, and filtering with diatomite filter to obtain endothelium corneum Gigeriae Galli filtrate.
8.4 Membrane separation, concentration, three times total
8.4.1 first separation
Separating the filtered chicken's gizzard-membrane feed liquid by using a rolling type ultrafiltration membrane with the molecular weight of 5 ten thousand, collecting the feed liquid penetrating through the filter membrane for later use, and discarding the macromolecular impurity liquid which does not penetrate through the filter membrane.
8.4.2 second separation, concentration
Separating and concentrating the permeate liquid separated by using 5 ten thousand molecular weight for the first time by using a roll type ultrafiltration membrane with the molecular weight of 3000, and respectively collecting the concentrated liquid which does not permeate the filter membrane and the liquid which permeates the filter membrane for later use.
8.4.3 third separation, concentration
Separating and concentrating the filtrate separated by the filter membrane with molecular weight of 3000 for the second time by using a rolled nanofiltration membrane with molecular weight of 100, collecting the concentrated filtrate which does not permeate the filter membrane for later use, and discarding the waste liquid permeating the filter membrane.
8.5 combining the concentrated feed liquids
Mixing the concentrated feed liquids of 3000 molecular weight filter membrane and 100 molecular weight filter membrane, stirring to obtain concentrated feed liquid of endothelium corneum Gigeriae Galli with relative density of 1.15-1.25, and refrigerating for use.
8.6 Freeze drying
Putting the refrigerated endothelium corneum gigeriae galli concentrated feed liquid into a capacity tray of a drying bin of a freeze dryer (FD-50 type freeze dryer manufactured by Changzhou Pantafeng drying equipment Co., Ltd.), setting the temperature of a probe to-50 ℃ before starting, setting the temperature of a cold trap to-50 ℃, changing the liquid state into a frozen solid state after 10-12 hours after starting, starting a vacuum system when the temperature of the probe reaches-50 ℃, starting a heating system for sublimation when the vacuum degree reaches 2MPa, setting the upper limit of the heating system to be 30 ℃, and obtaining endothelium gigeriae galli freeze-dried powder with the moisture of less than 5 percent after 14-18 hours of sublimation and drying.
Preparation of cinnamon cold dry powder
9.1 pretreatment of cinnamon
Selecting dry cinnamon, removing impurities, cleaning, drying in the air, crushing into coarse powder of 30-40 meshes, and weighing 100 kg for later use.
9.2 ethanol extraction of cinnamon twice
9.2.1 first ethanol extraction
Putting the crushed cinnamon coarse powder into a multifunctional extraction tank, adding 1500 kilograms of 80-degree ethanol for reflux extraction at the extraction temperature of 75 +/-1 ℃ for 155 minutes, recovering the ethanol, squeezing to obtain juice, and collecting residues.
9.2.2 second ethanol extraction
Putting the material residue collected after the first ethanol extraction into a multifunctional extraction tank, adding 1500 kg of 30-degree ethanol for reflux extraction at the extraction temperature of 80 +/-1 ℃ for 125 minutes, recovering the ethanol, squeezing juice and discarding the material residue.
9.3 Combined filtration
Mixing the cortex Cinnamomi extractive solutions extracted with ethanol, and filtering with diatomite filter to obtain cortex Cinnamomi filtrate.
9.4 Membrane separation, concentration, three times in total
9.4.1 first separation
The filtered feed liquid of cinnamon is separated by a rolling type ultrafiltration membrane with 5 ten thousand molecular weight, the feed liquid passing through the filter membrane is collected for standby, and the macromolecular impurity liquid not passing through the filter membrane is discarded.
9.4.2 separating and concentrating for the second time
Separating and concentrating the permeated material separated by the 5 ten thousand molecular weight filter membrane for the first time by using a roll type ultrafiltration membrane with the molecular weight of 3000, and respectively collecting the concentrated feed liquid which does not permeate the filter membrane and the feed liquid which permeates the filter membrane for later use.
9.4.3 separating and concentrating for the third time
Separating and concentrating the filtrate separated by the filter membrane with molecular weight of 3000 for the second time by using a rolled nanofiltration membrane with molecular weight of 100, collecting the concentrated filtrate which does not permeate the filter membrane for later use, and discarding the waste liquid permeating the filter membrane.
9.5 mixing the concentrated solutions
Mixing the concentrated feed liquid of 3000 molecular weight filter membrane and 100 molecular weight filter membrane, stirring to obtain concentrated feed liquid of cortex Cinnamomi with relative density of 1.15-1.25, and refrigerating for use.
9.6 Freeze drying
Putting the refrigerated cinnamon concentrated solution into a capacity tray of a drying bin of a freeze dryer (FD-50 type freeze dryer manufactured by Renzhou Torpeng drying equipment Co., Ltd.), setting the temperature of a probe to-50 ℃ before starting, setting the temperature of a cold trap to-50 ℃, changing the liquid state into a frozen solid state after 10-12 hours after starting, starting a vacuum system after the temperature of the probe reaches-50 ℃, starting a heating system for sublimation when the vacuum degree reaches 2MPa, setting the online of the heating system to be 30 ℃, and obtaining the cinnamon freeze-dried powder with the moisture of less than 5 percent after sublimation and drying for 14-18 hours.
Ten, the preparation and the preparation of the granules are calculated according to 100 kg of the instant health-care granules of the ginseng, the oyster
10.1 pulverizing and sieving
Weighing 0.4 kg of vitamin C, 2 kg of citric acid, 25 kg of xylitol, 0.03 kg of aspartame and 57.57 kg of beta-cyclodextrin according to parts by mass, respectively sieving with a 100-mesh sieve or sieving with a 100-mesh sieve after crushing, then adding 2.4 kg of diaphragma juglandis freeze-dried powder, 2.4 kg of rape bee pollen freeze-dried powder, 1.4 kg of red ginseng freeze-dried powder, 1.8 kg of lindera leaf freeze-dried powder, 1.8 kg of toona sinensis freeze-dried powder, 1.4 kg of oyster peptide freeze-dried powder, 1.8 kg of astragalus membranaceus freeze-dried powder, 1.2 kg of endothelium corneum gigeriae galli freeze-dried powder and 0.8 kg of cinnamon freeze-dried powder, and mixing with the crushed and sieved vitamin C, citric acid, xylitol, aspartame and beta-cyclodextrin.
10.2 mixing and granulating
Mixing the above materials, stirring, granulating with a one-step granulator, and grading with 12-14 mesh sieve.
10.3 packaging
Packaging the processed granules according to the packaging requirements, inspecting various indexes, and leaving the factory after the granules are qualified.
Eleven, effect after drinking
5 old men and women with frequent micturition, unclean urination, soreness and weakness of waist and knees and physical fatigue are selected, the average age is 70 years old, the old men and women are used for trial drinking, 30 g of the old men and women are drunk every day, and the old men and women are drunk once in the morning, the noon and the evening, 10 g of the old men and women are drunk each time, and after the old men and women are continuously drunk for 15 days, wherein the frequent micturition phenomenon of 4 women and 3 men is better improved, the frequent micturition phenomenon at night is better relieved, the enuresis is also improved, and the fatigue and fatigue are also better improved.
Example 2
Active type instant health-care granule containing ginseng, oyster and its preparing process
Firstly, the method comprises the following steps: preparation of diaphragma juglandis freeze-dried powder
Same as example 1
Second, preparation of rape bee pollen freeze-dried powder
Same as example 1
Preparation of red ginseng freeze-dried powder
Same as example 1
Preparation of freeze-dried powder of four-nerved spicebush leaf
Same as example 1
Preparation of Chinese toon freeze-dried powder
Same as example 1
Preparation of oyster peptide freeze-dried powder
Same as example 1
Preparation of freeze-dried powder of seven kinds of astragalus root and astragalus root
Same as example 1
Preparation of endothelium corneum gigeriae galli freeze-dried powder
Same as example 1
Preparation of freeze-dried powder of' Jiuzui
Same as example 1
Tenth, blending and manufacturing of the particles: calculated according to 100 kg of instant health-care granules containing ginseng, oyster and other Chinese medicinal herbs
10.1 pulverizing and sieving
Weighing 1 kg of vitamin C, 4 kg of citric acid, 30 kg of cane sugar, 0.05 kg of glutathione and 33.55 kg of beta-cyclodextrin according to the mass parts, respectively sieving with a 100-mesh sieve or crushing and then sieving with a 100-mesh sieve, then weighing 5 kg of diaphragma juglandis freeze-dried powder, 5 kg of rape bee pollen freeze-dried powder, 3 kg of red ginseng freeze-dried powder, 3.8 kg of lindera leaf freeze-dried powder, 3.8 kg of Chinese toon freeze-dried powder, 3 kg of oyster peptide freeze-dried powder, 3.8 kg of astragalus root freeze-dried powder, 2.4 kg of chicken's gizzard-membrane freeze-dried powder and 1.6 kg of cinnamon freeze-dried powder, and mixing the vitamin C, the citric acid, the cane sugar and the beta-cyclodextrin after crushing and sieving.
10.2 blend granulation
Same as example 1
10.3 packaging
Same as example 1
In this example, sucrose was added, and the diabetic patients were not suitable for drinking.
Eleven, effect after drinking
5 old men and women with frequent micturition, unclean urination, soreness and weakness of waist and knees and physical fatigue are selected, the average age is 72 years old, the old men and women are used for trial drinking, 30 g of the old men and women are drunk every day, 10 g of the old men and women are drunk in the morning, the old men and women are drunk in the evening and 10 days continuously, the phenomena of frequent micturition and frequent nocturia and the phenomenon of enuresis are improved to a certain extent, after the old men and women drink the old men for 15 days, the situations of frequent micturition and frequent nocturia are obviously improved, the phenomena of lumbago and fatigue weakness are also well improved, particularly, the two legs walk forcefully compared with the former, wherein two men have the morning erection phenomenon.
Example 3
Common general type instant health-care granule containing ginseng, oyster and other Chinese medicinal herbs
Firstly, the method comprises the following steps: preparation of diaphragma juglandis freeze-dried powder
Same as example 1
Second, preparation of rape bee pollen freeze-dried powder
Same as example 1
Preparation of red ginseng freeze-dried powder
Same as example 1
Preparation of freeze-dried powder of four-nerved spicebush leaf
Same as example 1
Preparation of Chinese toon freeze-dried powder
Same as example 1
Preparation of oyster peptide freeze-dried powder
Same as example 1
Preparation of freeze-dried powder of seven kinds of astragalus root and astragalus root
Same as example 1
Preparation of endothelium corneum gigeriae galli freeze-dried powder
Same as example 1
Preparation of freeze-dried powder of' Jiuzui
Same as example 1
Tenth, blending and manufacturing of the particles: calculated according to 100 kg of instant health-care granules containing ginseng, oyster and other Chinese medicinal herbs
10.1: pulverizing and sieving
Weighing 0.65 kg of vitamin C, 2.75 kg of citric acid, 10 kg of xylitol, 35 kg of sucrose and 31.8 kg of beta-cyclodextrin according to the mass parts, and respectively sieving with a 100-mesh sieve or sieving with a 100-mesh sieve after crushing. Then 3.2 kg of diaphragma juglandis freeze-dried powder, 3.2 kg of rape bee pollen freeze-dried powder, 1.8 kg of red ginseng freeze-dried powder, 2.4 kg of lindera root leaf freeze-dried powder, 2.4 kg of toona sinensis freeze-dried powder, 1.8 kg of oyster peptide freeze-dried powder, 2.4 kg of astragalus membranaceus freeze-dried powder, 1.6 kg of endothelium corneum gigeriae galli freeze-dried powder and 1 kg of cinnamon freeze-dried powder are weighed and mixed with the crushed and sieved vitamin C, citric acid, xylitol, sucrose and beta-cyclodextrin together.
10.2 blend granulation
Same as example 1
10.3 packaging
Same as example 1
The sucrose is added in the example, and the diabetic is not suitable for drinking
Eleven, effect after drinking
6 women with excessive menstruation and long menstruation are selected, the average age is 41 years old, the trial drinking experience is made, 30 g of the trial drinking is taken every day, 10 g of the trial drinking is taken once in the morning, in the middle and at night, the trial drinking is carried out for 10 days continuously, the menstruation amount is well controlled, the menstruation time is recovered to about 4-6 days from about 7-10 days before, the phenomena of soreness and pain of waist and knees and pain of lower abdomen are relieved, and the complexion is also well improved.
Example 4
Nutritional type instant health-care granule containing ginseng, oyster and other Chinese medicinal herbs
Firstly, the method comprises the following steps: preparation of diaphragma juglandis freeze-dried powder
Same as example 1
Second, preparation of rape bee pollen freeze-dried powder
Same as example 1
Preparation of red ginseng freeze-dried powder
Same as example 1
Preparation of freeze-dried powder of four-nerved spicebush leaf
Same as example 1
Preparation of Chinese toon freeze-dried powder
Same as example 1
Preparation of oyster peptide freeze-dried powder
Same as example 1
Preparation of freeze-dried powder of seven kinds of astragalus root and astragalus root
Same as example 1
Preparation of endothelium corneum gigeriae galli freeze-dried powder
Same as example 1
Preparation of freeze-dried powder of' Jiuzui
Same as example 1
Tenth, blending and manufacturing of the particles: calculated according to 100 kg of instant health-care granules containing ginseng, oyster and other Chinese medicinal herbs
10.1 crushing and sieving
Weighing 0.8 kg of vitamin C, 3.3 kg of citric acid, 16 kg of xylitol, 0.03 kg of glutathione, 0.02 kg of aspartame, 34.75 kg of beta-cyclodextrin and 20 kg of sucrose according to the mass parts, respectively sieving with a 100-mesh sieve or crushing, sieving with a 100-mesh sieve, then weighing 4 kg of diaphragma juglandis freeze-dried powder, 4 kg of rape bee pollen freeze-dried powder, 2.4 kg of red ginseng freeze-dried powder, 3 kg of lindera leaf freeze-dried powder, 3 kg of toona sinensis freeze-dried powder, 2.4 kg of oyster peptide freeze-dried powder, 3 kg of astragalus root freeze-dried powder, 2 kg of chicken's gizzard-membrane freeze-dried powder and 1.3 kg of cinnamon freeze-dried powder, and mixing with the crushed and sieved vitamin C, citric acid, xylitol, glutathione, aspartame, sucrose and beta-cyclodextrin.
10.2 blend granulation
Same as example 1
10.3, packaging
Same as example 1
In this example, sucrose was added, and the diabetic patients were not suitable for drinking.
Eleven, effect after drinking
5 women suffering from menorrhagia and sometimes endless dripping are selected, the average age of the women is 45 years, the women are subjected to trial drinking experience, 30 g of the women are drunk every day, the women are drunk in the morning, the noon and the evening once, 10 g of the women are drunk every time, the women continuously insist on drinking for 15 days, the menoxenia is obviously reduced, dripping is well controlled, the menstrual cycle is improved to 4-6 days from the previous 7-12 days, and diarrhea of one woman and frequent micturition of two women are also well improved.

Claims (3)

1. An instant health granule containing ginseng, oyster and the like is characterized by comprising the following components in parts by mass: the composition of the instant health-care granules comprises 100 parts of ginseng, wood and oyster: 2.4-5 parts of diaphragma juglandis freeze-dried powder, 2.4-5 parts of rape bee pollen freeze-dried powder, 1.4-3 parts of red ginseng freeze-dried powder, 1.8-3.8 parts of lindera root leaf freeze-dried powder, 1.8-3.8 parts of toona sinensis freeze-dried powder, 1.4-3 parts of oyster peptide freeze-dried powder, 1.8-3.8 parts of astragalus membranaceus freeze-dried powder, 1.2-2.4 parts of endothelium corneum gigeriae galli freeze-dried powder, 0.8-1.6 parts of cinnamon freeze-dried powder, 0.4-1 part of vitamin C, 2-4 parts of citric acid, 0-25 parts of xylitol, 0-0.03 part of aspartame, 0-0.05 part of glutathione and the balance.
2. The excipient of claim 1 is beta-cyclodextrin or sucrose.
3. The preparation method of the instant health-care granule containing the ginseng, the oyster and the ginseng according to claim 1 comprises the following steps:
firstly, preparing diaphragma juglandis freeze-dried powder:
1. pretreatment of the diaphragma juglandis:
taking dry diaphragma juglandis, cleaning, removing impurities, airing, and crushing into 20-30-mesh coarse powder for later use;
2. soaking and stirring diaphragma juglandis in ethanol:
putting the crushed heartwood coarse powder into a stainless steel soaking tank, adding 13 times by mass of 60-DEG ethanol, regulating the temperature to 33-35 ℃, carrying out closed soaking for 24-26 hours, starting the machine at intervals of 2 hours, stirring for once, stirring for 28-30 minutes each time, and stirring at the speed of 80 revolutions per minute;
3. extracting with ethanol twice
Putting the soaked and stirred coarse diaphragma juglandis powder and a soaking solution into a multifunctional extraction tank together for carrying out reflux extraction twice, wherein the temperature of the first extraction is 80 +/-1 ℃, the extraction time is 90-93 minutes, recovering ethanol, squeezing to obtain juice, collecting material residues, putting the material residues into the multifunctional extraction tank again, adding 35-degree ethanol which is 12 times of the mass of the coarse diaphragma juglandis powder, carrying out reflux extraction for the second time, the extraction temperature is 80 +/-1 ℃, the extraction time is 90-93 minutes, recovering the ethanol, and squeezing to obtain the juice and waste material residues;
4. filtration
Filtering the extracted diaphragma juglandis extract liquid by using a diatomite filter to obtain diaphragma juglandis filter liquid;
5. membrane separation, concentration, three times
Separating and concentrating the filtered feed liquid of the diaphragma juglandis by using a roll-type ultrafiltration membrane with the molecular weight of 5 ten thousand, a roll-type ultrafiltration membrane with the molecular weight of 3000 and a roll-type nanofiltration membrane with the molecular weight of 100 in turn, and discarding macromolecular impurity liquid with the molecular weight of more than 5 ten thousand, pigment and redundant waste liquid penetrating through the filter membrane with the molecular weight of 100;
6. mixing the concentrated solutions
Mixing the concentrated feed liquid of filter membrane with molecular weight of 3000 and filter membrane with molecular weight of 100, stirring to obtain concentrated feed liquid of diaphragma juglandis with relative density of 1.15-1.25, and refrigerating for use;
7. freeze drying
Feeding the refrigerated concentrated feed liquid of the diaphragma juglandis into a capacity tray of a drying bin of a freeze dryer, setting the temperature of a probe to be-50 ℃ before starting, changing the liquid state into a frozen solid state after 10-12 hours after starting, setting the upper limit of a heating system to be 30 ℃, and obtaining the diaphragma juglandis freeze-dried powder with the water content of less than 5 percent after sublimation and drying for 14-18 hours;
second, preparation of rape bee pollen freeze-dried powder
1. Pretreatment of rape bee pollen
Selecting clean and well-broken rape bee pollen dry powder for later use;
2. extracting with ethanol and stirring for one time
Putting the dry powder of the rape bee pollen with the wall broken into a stainless steel soaking tank, adding 90-degree ethanol which is 15 times of the dry powder of the rape bee pollen by mass, adjusting the temperature to 38-41 ℃, carrying out closed leaching for 24-26 hours, starting the machine at intervals of 2 hours, stirring for once, stirring for 28-30 minutes each time, and stirring at the speed of 120 r/min;
3. centrifuging the ethanol extract
Separating the crude liquid of the rape bee pollen which is extracted and stirred by the ethanol and the leaching liquor for 15 minutes by using a high-speed butterfly centrifuge at the speed of 8000-plus 12000 r/min, separating clear liquid for later use, and collecting material residues for later use;
4. concentrating
Putting the ethanol leaching solution of rape bee pollen separated by a centrifuge into a vacuum concentration tank, regulating the temperature to 43-45 ℃, concentrating under reduced pressure for 2.5-3 hours, recovering ethanol, and collecting the concentrated solution for later use;
5. water leaching and stirring once
Putting the material residues into a stainless steel soaking tank, adding 15 times of drinking water by mass of rape bee pollen dry powder, adjusting the temperature to 38-41 ℃, carrying out closed leaching for 7.5-8 hours, starting up and stirring once every 2 hours, wherein the stirring speed is 120 revolutions per minute;
6. centrifugation of aqueous extract
The rape bee pollen which is extracted and stirred by water and the leaching liquor are separated for 15 minutes by a high-speed butterfly centrifuge at the speed of 8000-12000 r/min, clear liquid is separated for standby, and material residues are discarded;
7. combining filters
Mixing the concentrated solution obtained by soaking in ethanol and the solution obtained by soaking in water and centrifuging, and filtering with diatomite filter;
8. membrane separation, concentration and three times of separation
Sequentially separating and concentrating the filtered rape bee pollen feed liquid by using a roll-type ultrafiltration membrane with the molecular weight of 5 ten thousand, a roll-type ultrafiltration membrane with the molecular weight of 3000 and a roll-type nanofiltration membrane with the molecular weight of 100, and discarding macromolecular impurity liquid with the molecular weight of more than 5 ten thousand, pigment and redundant waste liquid penetrating through the filter membrane with the molecular weight of 100;
9. mixing the concentrated solutions
Mixing the concentrated feed liquid of 3000 molecular weight filter membrane and the concentrated feed liquid of 100 molecular weight filter membrane, stirring to obtain concentrated feed liquid of rape bee pollen with relative density of 1.15-1.25, and refrigerating for use;
10. freeze drying
Feeding the cold-stored concentrated feed liquid of rape bee pollen into a capacity tray of a drying bin of a freeze dryer, setting the temperature of a probe to be-50 ℃ before starting, changing the liquid state into a frozen solid state after 10-12 hours after starting, setting the upper limit of a heating system to be 30 ℃, and obtaining the freeze-dried powder of the rape bee pollen with the moisture of less than 5 percent after sublimation and drying for 14-18 hours;
preparation of red ginseng freeze-dried powder
1. Pretreatment of red ginseng
Taking dry red ginseng slices, cleaning, removing impurities, airing, and crushing into 20-30 meshes of coarse powder for later use;
2. ethanol soaking and stirring of red ginseng
Putting the ground red ginseng coarse powder into a stainless steel soaking tank, adding 60-degree ethanol in an amount which is 10 times the mass of the red ginseng coarse powder, soaking for 24-26 hours at the normal temperature of 33-35 ℃ in a closed manner, starting the machine at intervals of 2 hours, and stirring for 28-30 minutes every time, wherein the stirring speed is 70 revolutions per minute;
3. extracting with ethanol twice
Putting the soaked and stirred red ginseng coarse powder and a soaking solution into a multifunctional extraction tank together for carrying out first reflux extraction, wherein the extraction temperature is 70 +/-1 ℃, the extraction time is 90-93 minutes, recovering ethanol, squeezing to obtain juice, collecting material residues, putting the squeezed material residues obtained in the first extraction into the multifunctional extraction tank again, adding 60-DEG C ethanol which is 10 times of the mass of the red ginseng coarse powder for carrying out second reflux extraction, the extraction temperature is 70 +/-1 ℃, the extraction time is 90-93 minutes, recovering the ethanol, squeezing to obtain juice, and collecting the material residues for later use;
4. twice with water
Putting red ginseng residue after ethanol extraction into a multifunctional extraction tank, performing reflux extraction twice by using drinking water, adding 10 times of drinking water by mass of red ginseng coarse powder each time, wherein the extraction temperature of the two times is 70 +/-1 ℃, the extraction time of each time is 90-93 minutes, squeezing to obtain juice, and discarding residue;
5. combining filters
Mixing the Ginseng radix Rubri solution extracted with ethanol twice and the Ginseng radix Rubri solution extracted with water twice, and filtering with diatomite filter to obtain Ginseng radix Rubri mixed filtrate;
6. membrane separation, concentration, three times
Separating and concentrating the filtered red ginseng feed liquid by using a roll-type ultrafiltration membrane with the molecular weight of 5 ten thousand, a roll-type ultrafiltration membrane with the molecular weight of 3000 and a roll-type nanofiltration membrane with the molecular weight of 100 in sequence, and discarding macromolecular impurity liquid with the molecular weight of more than 5 ten thousand, pigment and redundant waste liquid penetrating through the filter membrane with the molecular weight of 100;
7. mixing the concentrated solutions
Mixing the concentrated feed liquid of filter membrane with molecular weight of 3000 and filter membrane with molecular weight of 100, stirring to obtain concentrated feed liquid of Ginseng radix Rubri with relative density of 1.15-1.25, and refrigerating;
8. freeze drying
Feeding the refrigerated red ginseng concentrated feed liquid into a capacity tray of a drying bin of a freeze dryer, setting the temperature of a probe to be-50 ℃ before starting up, changing the liquid state into a frozen solid state after 10-12 hours after starting up, setting the upper limit of a heating system to be 30 ℃, and obtaining red ginseng freeze-dried powder with the water content of less than 5 percent after sublimation and drying for 14-18 hours;
preparation of freeze-dried powder of four-nerved spicebush leaf
1. Pretreatment of lindera aggregate leaves
Taking dry lindera aggregate leaves, cleaning, removing impurities, drying in the air, and crushing into 20-30 mesh coarse powder for later use;
2. soaking folium Linderae Strychnifoliae in ethanol under stirring
Putting the lindera aggregate leaf coarse powder into a stainless steel soaking tank, adding 70-degree ethanol in an amount which is 20 times the mass of the lindera aggregate leaf coarse powder, regulating the temperature to 33-35 ℃, carrying out closed soaking for 24-26 hours, starting up the machine every 2 hours, and stirring for 28-30 minutes every time at a stirring speed of 80 revolutions per minute;
3. extracting with ethanol twice
Putting the soaked and stirred crude powder of the lindera aggregate leaves and a soaking solution into a multifunctional extraction tank for reflux extraction, wherein the first extraction time is 90-93 minutes, the extraction temperature is 70 +/-1 ℃, recovering ethanol, pressing to obtain juice, putting material residues into the multifunctional extraction tank, adding 15 times of 50-DEG ethanol by mass of the crude powder of the lindera aggregate leaves, performing second reflux extraction, the extraction time is 90-93 minutes, the extraction temperature is 70 +/-1 ℃, recovering ethanol, pressing to obtain juice, and collecting the material residues for later use;
4. water extraction once
Putting the collected folium Linderae Strychnifoliae residues into a multifunctional extraction tank, adding 15 times of drinking water by mass of folium Linderae Strychnifoliae coarse powder, reflux-extracting for 125 minutes at 70 + -1 deg.C for 120 times, squeezing to obtain juice, and discarding residues;
5. combining filters
Mixing the folium Linderae Strychnifoliae extractive solution extracted with ethanol twice and the folium Linderae Strychnifoliae extractive solution extracted with water once, and filtering with diatomite filter to obtain folium Linderae Strychnifoliae filtrate;
6. membrane separation, concentration, three times
Sequentially separating the filtered lindera aggregata leaf feed liquid by using a roll-type ultrafiltration membrane with the molecular weight of 5 ten thousand, a roll-type ultrafiltration membrane with the molecular weight of 3000 and a roll-type nanofiltration membrane with the molecular weight of 100, concentrating, and discarding macromolecular impurity liquid with the molecular weight of more than 5 ten thousand, pigment and redundant waste liquid penetrating through the filter membrane with the molecular weight of 100;
7. mixing the concentrated solutions
Mixing the concentrated solution of filter membrane with molecular weight of 3000 and filter membrane with molecular weight of 100, stirring to obtain concentrated solution of folium Linderae Strychnifoliae with relative density of 1.15-1.25, and refrigerating;
8. freeze drying
Feeding the refrigerated concentrated folium Linderae Strychnifoliae feed liquid into a capacity tray of a drying bin of a freeze dryer, setting the temperature of a probe to-50 ℃ before starting up, changing the liquid state into a frozen solid state after 10-12 hours after starting up, setting the upper limit of a heating system to 30 ℃, and obtaining the folium Linderae Strychnifoliae freeze-dried powder with the water content of less than 5% after sublimation and drying for 14-18 hours;
preparation of Chinese toon freeze-dried powder
1. Pretreatment of cedrela sinensis
Taking dried Chinese toon, cleaning, removing impurities, airing and crushing into 20-30-mesh coarse powder for later use;
2. ethanol soaking and stirring of cedrela sinensis
Putting the toona sinensis coarse powder into a stainless steel soaking tank, adding 70-degree ethanol 15 times the mass of the toona sinensis coarse powder, regulating the temperature to 33-35 ℃, carrying out closed soaking for 46-48 hours, starting up and stirring once every two hours, wherein the stirring speed is 80 revolutions per minute;
3. extracting with ethanol for four times
Putting the soaked and stirred toona sinensis coarse powder and a soaking solution into a multifunctional extraction tank for reflux extraction, wherein the first extraction time is 90-93 minutes, the extraction temperature is 70 +/-1 ℃, recovering ethanol, putting material residues into the multifunctional extraction tank after squeezing juice, adding 12 times of 70-DEG C ethanol by mass of the toona sinensis coarse powder for second reflux extraction for 90-93 minutes, the extraction temperature is 70 +/-1 ℃, recovering ethanol, putting the material residues into the multifunctional extraction tank after squeezing juice, adding 10 times of 70-DEG C ethanol by mass of the toona sinensis coarse powder for third reflux extraction, the extraction time is 90-93 minutes, the extraction temperature is 70 +/-1 ℃, recovering ethanol, putting the material residues into the multifunctional extraction tank after juice is obtained, adding 8 times of 35-DEG C ethanol by mass of the toona sinensis coarse powder for fourth reflux extraction, extracting for 90-93 min at 70 + -1 deg.C, recovering ethanol, squeezing to obtain juice, and collecting residue;
4. water extraction once
Putting the Chinese toon material residues into a multifunctional extraction tank, adding 25 times of drinking water by mass of the Chinese toon coarse powder for reflux extraction, wherein the extraction time is 2.3-2.5 hours, the extraction temperature is 70 +/-1 ℃, then squeezing juice, and discarding the material residues;
5. combining filters
Mixing the ethanol-extracted toona sinensis liquid of the fourth time and the toona sinensis liquid of the first time, and filtering with a diatomite filter to obtain a toona sinensis filtering liquid;
6. membrane separation, concentration, three times
Separating and concentrating the filtered toona sinensis feed liquid by using a roll-type ultrafiltration membrane with the molecular weight of 5 ten thousand, a roll-type ultrafiltration membrane with the molecular weight of 3000 and a roll-type nanofiltration membrane with the molecular weight of 100 in sequence, and discarding macromolecular impurity liquid with the molecular weight of more than 5 ten thousand, pigment and redundant waste liquid penetrating through the filter membrane with the molecular weight of 100;
7. mixing the concentrated solutions
Mixing the concentrated feed liquid of filter membrane with molecular weight of 3000 and filter membrane with molecular weight of 100, stirring to obtain concentrated feed liquid of Toona sinensis with relative density of 1.15-1.25, and refrigerating for use;
8. freeze drying
Feeding the refrigerated concentrated feed liquid of the cedrela sinensis into a capacity tray of a drying bin of a freeze dryer, setting the temperature of a probe to be-50 ℃ before starting, changing the liquid state into a frozen solid state after 10-12 hours after starting, setting the upper limit of a heating system to be 30 ℃, and obtaining the cedrela sinensis freeze-dried powder with the water content of less than 5% after sublimation and drying for 14-18 hours;
preparation of oyster freeze-dried powder
1. Pretreatment of oysters
Soaking live oysters in water for 46-48 hours, dripping a few drops of sesame oil in the water during soaking, brushing the shells cleanly with a brush, taking out oyster meat after the shells are opened, cleaning impurities such as internal organs and the like, putting the oyster meat into a mincing machine after the shells are cleaned, smashing the oyster meat into pulp, adding water with the mass part being 3 times that of the oyster meat, grinding the pulp into fine pulp through a water mill, and refrigerating for later use;
2. enzymolysis
Firstly, preliminary enzymolysis: putting the feed liquid into a reaction kettle, adding bromelain and papain, heating, keeping the temperature at 55 +/-1 ℃, adjusting the pH value to 6, and reacting for 5-5.5 hours;
② secondary enzymolysis
Adding flavor protease into the feed liquid after primary enzymolysis, keeping the temperature at 53 +/-1 ℃, and reacting for the following time: 2.3-2.5 hours;
③ enzyme and sterilization
After the second enzymolysis, heating the feed liquid to 90 +/-1 ℃ in the original reaction kettle, inactivating the enzyme for 18-20 minutes, and sterilizing the feed liquid by a sterilizer at 105 ℃;
3. fishy smell removing device
Cooling the oyster enzymolysis liquid after enzyme deactivation to 43-45 ℃ in an original reaction kettle, adding Angel yeast and cyclodextrin, keeping the temperature at 43-45 ℃ and removing fishy smell for 55-60 minutes;
4. centrifuging and filtering
Adding 10-degree ethanol in an amount which is 3 times the mass of the oyster enzymolysis liquid into the oyster enzymolysis liquid, uniformly stirring, standing for 48-50 hours, centrifuging by using a butterfly high-speed centrifuge, and filtering by using a diatomite filter to obtain oyster peptide feed liquid;
5. membrane separation, concentration, three times
Separating and concentrating the filtered oyster peptide feed liquid by using a roll-type ultrafiltration membrane with the molecular weight of 5 ten thousand, a roll-type ultrafiltration membrane with the molecular weight of 3000 and a roll-type reverse osmosis membrane in sequence, and discarding macromolecular impurity liquid with the molecular weight of more than 5 ten thousand, pigment and redundant wastewater penetrating through the reverse osmosis membrane;
6. mixing the concentrated solutions
Mixing the concentrated feed liquid of the filter membrane with the molecular weight of 3000 and the reverse osmosis filter membrane, stirring to obtain the concentrated feed liquid of the oyster peptide with the relative density of 1.15-1.25, and refrigerating for later use;
7. freeze drying
Directly putting the refrigerated oyster peptide concentrated feed liquid into a capacity tray of a drying bin of a freeze dryer, setting the temperature of a probe to be 50 ℃ below zero before starting up, changing the liquid state into a frozen state after 10 to 12 hours after starting up, setting the upper limit of a heating system to be 30 ℃, and obtaining the oyster peptide freeze-dried powder with the water content of less than 5 percent after sublimation and drying for 14 to 18 hours;
preparation of freeze-dried powder of seven kinds of astragalus root and astragalus root
1. Pretreatment of astragalus membranaceus
Taking dry radix astragali, cleaning, removing impurities, air drying, and pulverizing into 20-30 mesh coarse powder for use;
2. soaking radix astragali in ethanol, and stirring
Putting the astragalus coarse powder into a stainless steel soaking tank, adding 85-degree ethanol in an amount which is 12 times the mass of the astragalus coarse powder, regulating the temperature to 33-35 ℃, carrying out closed soaking for 24-26 hours, starting the machine at intervals of two hours, and stirring for 28-30 minutes every time, wherein the stirring speed is 70 revolutions per minute;
3. extracting radix astragali with ethanol twice
Putting the soaked astragalus coarse powder and the soak solution into a multifunctional extraction tank for reflux extraction, wherein the extraction time is 90-93 minutes, the extraction temperature is 75 +/-1 ℃, recovering ethanol, pressing to obtain juice, putting the residues into the multifunctional extraction tank again, adding 10 times of 85-DEG C ethanol by mass of the astragalus coarse powder for reflux extraction, the extraction temperature is 75 +/-1 ℃, the extraction time is 90-93 minutes, pressing to obtain juice, and collecting the residues;
4. twice with water
Putting the astragalus mongholicus dregs into a multifunctional extraction tank, adding 15 times of drinking water by mass of astragalus mongholicus coarse powder for reflux extraction, wherein the extraction time is 90-93 minutes, the extraction temperature is 75 +/-1 ℃, putting the dregs into the multifunctional extraction tank after squeezing juice, adding 15 times of drinking water by mass of the astragalus mongholicus coarse powder for secondary reflux extraction, the extraction temperature is 75 +/-1 ℃, the extraction time is 90-93 minutes, squeezing the juice, and discarding the dregs;
5. combining filters
Mixing the radix astragali liquid extracted twice with ethanol and the radix astragali liquid extracted twice with water, and filtering with diatomite filter to obtain radix astragali filtrate;
6. membrane separation, concentration, three times
Sequentially separating and concentrating the filtered astragalus feed liquid by using a roll-type ultrafiltration membrane with the molecular weight of 5 ten thousand, a roll-type ultrafiltration membrane with the molecular weight of 3000 and a roll-type nanofiltration membrane with the molecular weight of 100, and discarding macromolecular impurity liquid with the molecular weight of more than 5 ten thousand, pigment and redundant waste liquid penetrating through the filter membrane with the molecular weight of 100;
7. mixing the concentrated solutions
Mixing the concentrated feed liquid of filter membrane with molecular weight of 3000 and filter membrane with molecular weight of 100, stirring to obtain radix astragali concentrated feed liquid with relative density of 1.15-1.25, and refrigerating for use;
8. freeze drying
Feeding the refrigerated radix astragali concentrated feed liquid into a capacity tray of a drying bin of a freeze dryer, setting the temperature of a probe to-50 ℃ before starting, changing the liquid state into a frozen solid state after 10-12 hours after starting, setting the upper limit of a heating system to 30 ℃, and obtaining radix astragali freeze-dried powder with the water content of less than 5% after sublimation and drying for 14-18 hours;
preparation of endothelium corneum gigeriae galli freeze-dried powder
1. Pretreatment of endothelium corneum gigeriae galli
Cleaning vinegar-fried dried endothelium corneum Gigeriae Galli, removing impurities, air drying, and pulverizing into 60 mesh powder;
2. twice with water
Putting the endothelium corneum gigeriae galli medium powder into a multifunctional extraction tank, adding 10 times by mass of drinking water into the endothelium corneum gigeriae galli medium powder for reflux extraction at the extraction temperature of 80 +/-1 ℃ for 60-63 minutes, pressing to obtain juice, putting the material residues into the multifunctional extraction tank again, adding 8 times by mass of drinking water into the endothelium corneum gigeriae galli medium powder for reflux extraction at the extraction temperature of 80 +/-1 ℃ for 45-48 minutes, pressing to obtain juice, and discarding the material residues;
3. combining filters
Mixing the endothelium corneum Gigeriae Galli extractive solutions extracted with water twice, and filtering with diatomite filter to obtain endothelium corneum Gigeriae Galli filtrate;
4. membrane separation, concentration, three times
Sequentially separating and concentrating the filtered endothelium corneum Gigeriae Galli feed liquid with a roll-type ultrafiltration membrane with molecular weight of 5 ten thousand, a roll-type ultrafiltration membrane with molecular weight of 3000 and a roll-type nanofiltration membrane with molecular weight of 100, and discarding macromolecular impurity liquid with molecular weight of more than 5 ten thousand, pigment and redundant waste liquid passing through the nanofiltration membrane with molecular weight of 100;
5. mixing the concentrated solutions
Mixing the concentrated feed liquid of filter membrane with molecular weight of 3000 and filter membrane with molecular weight of 100, stirring to obtain concentrated feed liquid of endothelium corneum Gigeriae Galli with relative density of 1.15-1.25, and refrigerating;
6. freeze drying
Putting the refrigerated endothelium corneum Gigeriae Galli concentrated feed liquid into a capacity tray of a drying bin of a freeze dryer, setting the temperature of a probe to-50 ℃ before starting up, changing the liquid state into a frozen solid state after 10-12 hours after starting up, setting the upper limit of a heating system to 30 ℃, and obtaining endothelium corneum Gigeriae Galli freeze-dried powder with the water content of less than 5% after sublimation and drying for 14-18 hours;
preparation of freeze-dried powder of' Jiuzui
1. Pretreatment of cinnamon
Selecting dry cinnamon, cleaning, removing impurities, airing, and crushing into coarse powder of 30-40 meshes for later use;
2. extracting cortex Cinnamomi with ethanol twice
Putting the cinnamon coarse powder into a multifunctional extraction tank, adding 80-degree ethanol 15 times the mass of the cinnamon coarse powder for reflux extraction at the extraction temperature of 75 +/-1 ℃ for 155 minutes, recovering the ethanol, putting the material residues into the multifunctional extraction tank again after squeezing juice, adding 30-degree ethanol 15 times the mass of the cinnamon coarse powder for reflux extraction at the extraction temperature of 80 +/-1 ℃ for 125 minutes, recovering the ethanol, squeezing the juice, and discarding the waste residues;
3. combining filters
Mixing the cortex Cinnamomi extractive solutions extracted with ethanol twice, and filtering with diatomite filter to obtain cortex Cinnamomi filtrate;
4. membrane separation, concentration, three times
Separating and concentrating the filtered cinnamon feed liquid by using a roll-type ultrafiltration membrane with the molecular weight of 5 ten thousand, a roll-type ultrafiltration membrane with the molecular weight of 3000 and a roll-type nanofiltration membrane with the molecular weight of 100 in sequence, and discarding macromolecular impurity liquid with the molecular weight of more than 5 ten thousand, pigment and redundant waste liquid penetrating through the filter membrane with the molecular weight of 100;
5. mixing the concentrated solutions
Mixing the filter membrane with molecular weight of 3000 and the concentrated feed liquid with molecular weight of 100, stirring to obtain cortex Cinnamomi concentrated feed liquid with relative density of 1.15-1.25, and refrigerating;
6. freeze drying
Putting the refrigerated cinnamon concentrated solution into a capacity tray of a drying bin of a freeze dryer, setting the temperature of a probe to be 50 ℃ below zero before starting up, changing the liquid state into a frozen solid state after 10-12 hours after starting up, setting the upper limit of a heating system to be 30 ℃, and obtaining the cinnamon freeze-dried powder with the water content of less than 5% after sublimation and drying for 14-18 hours;
blending and making method of instant health granule of ten, mu, Shen and oyster
1. Pulverizing and sieving
Weighing 0.4-1 part of vitamin C, 2-4 parts of citric acid, 0-25 parts of xylitol, 0-0.03 part of aspartame and 0-0.05 part of glutathione according to the mass parts, respectively sieving with a 100-mesh sieve or sieving with a 100-mesh sieve after crushing, then weighing 2.4-5 parts of diaphragma juglandis freeze-dried powder, 2.4-5 parts of rape bee pollen freeze-dried powder, 1.4-3 parts of red ginseng freeze-dried powder, 1.8-3.8 parts of lindera aggregate leaf freeze-dried powder, 1.8-3.8 parts of Chinese toon freeze-dried powder, 1.4-3 parts of oyster peptide freeze-dried powder, 1.8-3.8 parts of astragalus root freeze-dried powder, 1.2-2.4 parts of chicken's gizzard-membrane freeze-dried powder and 0.8-1.6 parts of cinnamon freeze-dried powder, and mixing with the rest of crushed and sieved vitamin C, citric acid, aspartame, glutathione, xylitol and excipient;
2. mixing and granulating
Mixing the above materials, stirring, granulating with a one-step granulator, and grading with 12-14 mesh sieve;
3. package (I)
Packaging the processed granules according to the packaging requirements, and delivering the granules after various indexes are qualified through inspection.
CN202110506830.1A 2021-05-10 2021-05-10 Instant health-care granule containing ginseng, oyster and preparation method thereof Pending CN113287706A (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012050398A2 (en) * 2010-10-14 2012-04-19 주식회사 한국전통의학연구소 Pharmaceutical composition including herbal medicine extract for preventing or treating lung cancer
CN103520278A (en) * 2013-10-10 2014-01-22 北京康远制药有限公司 Traditional Chinese medicine granules having effects of invigorating qi and warming yang and preparation method thereof
CN104274754A (en) * 2014-10-30 2015-01-14 青岛恒波仪器有限公司 Traditional Chinese medicine composition for treating infantile enuresis and preparation method of traditional Chinese medicine composition
CN105920189A (en) * 2016-07-10 2016-09-07 马佳 Traditional Chinese medicine composition for treating talalgia due to liver-kidney deficiency and preparation method thereof
CN106109921A (en) * 2016-08-28 2016-11-16 福州海王金象中药制药有限公司 Tonifying kidney and prolonging life sheet preparation technology
CN111334549A (en) * 2020-02-21 2020-06-26 海南美肽生物科技有限公司 Oyster peptide and oyster peptide extraction method

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012050398A2 (en) * 2010-10-14 2012-04-19 주식회사 한국전통의학연구소 Pharmaceutical composition including herbal medicine extract for preventing or treating lung cancer
CN103520278A (en) * 2013-10-10 2014-01-22 北京康远制药有限公司 Traditional Chinese medicine granules having effects of invigorating qi and warming yang and preparation method thereof
CN104274754A (en) * 2014-10-30 2015-01-14 青岛恒波仪器有限公司 Traditional Chinese medicine composition for treating infantile enuresis and preparation method of traditional Chinese medicine composition
CN105920189A (en) * 2016-07-10 2016-09-07 马佳 Traditional Chinese medicine composition for treating talalgia due to liver-kidney deficiency and preparation method thereof
CN106109921A (en) * 2016-08-28 2016-11-16 福州海王金象中药制药有限公司 Tonifying kidney and prolonging life sheet preparation technology
CN111334549A (en) * 2020-02-21 2020-06-26 海南美肽生物科技有限公司 Oyster peptide and oyster peptide extraction method

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