CN101480491B - Bone collagen polypeptide composite solution for regulating intestines and preparation method thereof - Google Patents
Bone collagen polypeptide composite solution for regulating intestines and preparation method thereof Download PDFInfo
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- CN101480491B CN101480491B CN2009100425481A CN200910042548A CN101480491B CN 101480491 B CN101480491 B CN 101480491B CN 2009100425481 A CN2009100425481 A CN 2009100425481A CN 200910042548 A CN200910042548 A CN 200910042548A CN 101480491 B CN101480491 B CN 101480491B
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Abstract
The invention discloses a collagen polypeptide composite intestine solution and a preparation method thereof. The collagen polypeptide composite intestine solution is prepared by the following components by weight percentage: 3 to 28 percent of functional oligosaccharide, 5 to 15 percent of polyethylene glycol, 2 to 10 percent of collogen polypeptide powder, 1 to 5 percent of asparagus juice and surplus water. The collagen polypeptide composite intestine solution has the advantages of complete functions, good taste, obvious toxicant elimination effect and better health-care effect and can effectively adjust the environment of intestinal flora.
Description
Technical field
The invention belongs to technical field of food biotechnology, be specifically related to a kind of compound whole enteric liquid and preparation method thereof.
Background technology
People take in various foods in daily life, and the residue garbage of digesting and assimilating the back generation by body is trapped in the human body intestinal canal easily, by the effects such as noxious bacteria in the intestinal, generates a large amount of toxic products.It is just big more that these toxic products are trapped in the long more harm to human body of intravital time of people, can cause liver and function of intestinal canal disorder, is one of important cause of canceration, aging and various adult diseases.
At present, the whole intestinal health promoting beverage of composite multifunction is not arranged as yet on the market, the whole enteric liquid function of selling on the open market is comparatively single, only has a certain trophic function or health-care effect.Have the minority medicine to can be used for toxin expelling, but its majority can only let out under the relieving constipation, effect of ejecting poison is not good, can not improve flora environment in the human body intestinal canal, can not effectively promote probiotic bacteria propagation, and most whole intestinal class medicine or preparation have certain toxic and side effects.
Summary of the invention
The technical problem to be solved in the present invention is to overcome the deficiencies in the prior art, provide a kind of complete function, good mouthfeel, effect of ejecting poison obviously and can effectively regulate the bone collagen polypeptide composite solution for regulating intestines of intestinal microbial population environment, the preparation method of the bone collagen polypeptide composite solution for regulating intestines that a kind of technology is simple, cost is less also is provided.
For solving the problems of the technologies described above, the technical scheme that the present invention proposes is a kind of bone collagen polypeptide composite solution for regulating intestines, it is characterized in that described compound whole enteric liquid is formulated by the component of following mass fraction: 3%～28% functional oligose, 5%～15% Polyethylene Glycol, 2%～10% bone collagen polypeptide powder, 1%～5% Aloe juice and the water of surplus.
In the technique scheme, 3%～28% the functional oligose that comprises in the described compound whole enteric liquid is mixed by the soybean oligo saccharide of the oligofructose that accounts for compound whole enteric liquid mass fraction 1%～10%, 1%～10% oligomeric galactose and 1%～8% and forms.
In the technique scheme, the mass percent of polypeptide is 70%～80% in the described bone collagen polypeptide powder.
In the technique scheme, the water of described surplus is ultrafiltration water, deionized water or drinking water.
The present invention also provides a kind of preparation method of above-mentioned bone collagen polypeptide composite solution for regulating intestines, may further comprise the steps:
(1) prepares raw material: prepare required functional oligose, Polyethylene Glycol, Aloe juice and bone collagen polypeptide powder; Other prepares a certain amount of drinking water, perhaps light water is adopted ultrafiltration or ion-exchange process (for example can use DOWEX ion exchange resin) handle ultrafiltration water or deionized water; Described Aloe juice is that its meat obtains behind squeezing, fine straining with the Aloe peeling;
(2) preparation: above-mentioned ready raw material is pressed following mass percent mix homogeneously: functional oligose 3%～28%, Polyethylene Glycol 5%～15%, bone collagen polypeptide powder 2%～10% and Aloe juice 1%～5%, surplus are ultrafiltration water, deionized water or drinking water; 3%～28% the functional oligose that comprises in the described mixed material is preferably mixed by the soybean oligo saccharide of the oligofructose that accounts for mixed material mass fraction 1%～10%, 1%～10% oligomeric galactose and 1%～8% and forms;
(3) filtration sterilization: the mixed solution of above-mentioned preparation is filtered, and instantaneous ultrahigh-temperature sterilization (temperature of sterilization is generally 120～130 ℃, and sterilization time is 2～8 seconds) obtains finished product.
In the above-mentioned preparation method, described bone collagen polypeptide powder specifically is to make by the following method: get the Os Sus domestica bone and clean, first broken back boiling water steaming and decocting drains the bone piece and drying behind the oils and fats of removal cooking liquor top layer; Again the bone piece is carried out coarse pulverization, micronizing is made bone meal, adds water bone meal is mixed with bone mud liquid, high temperature sterilize (15min sterilizes under 85 ℃ of temperature) postcooling (naturally cooling to below 50 ℃) also adds the Protamex compound protease and carries out enzymolysis, enzyme denaturing; Get filtrate vacuum concentration and lyophilization after the filtration, obtain bone collagen polypeptide powder.In the preparation process of bone collagen polypeptide powder, the mass ratio of bone piece and water is 1: 1～1: 2 during the boiling water steaming and decocting, and the temperature during the boiling water steaming and decocting is controlled at 110 ℃～120 ℃, and pressure is controlled at 143kPa～198kPa, and the time is controlled at 30～60min.The addition of described Protamex compound protease is 2～2.5 ‰ of an enzymolysis substrate bone meal quality, and the pH value during described Protamex compound protease enzymolysis is 7.5, and temperature is controlled at 55 ℃, and enzymolysis time is 10～15h.Temperature when the bone piece is carried out drying is controlled at 80～85 ℃, and is dried to water content less than 5%; When the bone piece was carried out coarse crushing, micronizing, described bone piece was ground into the granularity of bone meal less than 160 orders; The mass concentration of described bone mud liquid is 10～15%.
The functional oligose that uses in the technique scheme has been widely used in milk product, lactobacillus beverage, bifidobacterium yoghurt, cereal foods and the health food as a kind of food ingredients.In health food, be that the oral liquid that raw material is made can directly be used for regulating intestinal microbial population, loosening bowel to relieve constipation with the oligosaccharide.In the technical scheme of the present invention, the preferred oligofructose that uses can make bacillus bifidus, lactobacillus propagation, bacillus perfringens is suppressed or does not breed, escherichia coli or enterococcus, bacteroid are not bred or the propagation amplitude is lower than bacillus bifidus or lactobacillus, have the function of certain adjusting gastrointestinal bacterial flora; Oligofructose is generated L-lactic acid at big enteral by bacterial fermentation, can dissolving calcium, mineral such as magnesium, ferrum, promote the absorption of human body to mineral, experiment confirm, oligofructose promotes the absorbance of calcium to reach 70.8%, mineral such as dissolved calcium, magnesium can form chelate with the nutrient ossein peptide that adds, and directly absorb to enter in the human body, take in the time of oligofructose and ossein peptide good facilitation has been played in the absorption of human body mineral.Because oligofructose can not directly be digested and assimilated by human body, so its calorific value is low, can not cause fat, and antiobesity action is also arranged indirectly, oligofructose also is a kind of good sweeting agent concerning diabetics.The compound whole enteric liquid that suitably increases the addition of oligofructose is suitable for crowd more, that whole enteric liquid mouthfeel is had relatively high expectations of noxious bacteria in the intestinal and the diabetics that needs bowel relieving.The oligomeric galactose of selecting for use among the present invention is refining through technologies such as enzymolysis dryings and female emulsive oligosaccharide that obtain, bacillus bifidus and lactobacillus to enteral have proliferation function, also have the effectiveness identical simultaneously, can promote enterogastric peristalsis, improve function of intestinal canal with the Plant fiber; The compound whole enteric liquid that suitably increases oligomeric galactose content is fit to the less crowd of daily exercise amount.The soybean oligo saccharide of selecting for use can only be made full use of by bacillus bifidus, promote the propagation of bacillus bifidus, be difficult to be utilized by other harmful bacterium, often the human consumption soybean oligosaccharide can make intravital bacillus bifidus quantity increase, promote intestinal peristalsis promoting, constipation is eased, and it also has the body of promotion and produces physiological functions such as vitamin B group, prevention and treatment bacillary dysentery; The crowd that the compound whole enteric liquid that suitably increases soybean oligo saccharide content is fit to lack vitamin B group and suffers from bacillary dysentery.More than 3 kinds of oligosaccharide have the effect that makes bacillus bifidus, lactobacillus propagation simultaneously.
The Polyethylene Glycol of selecting for use in the technique scheme is that medical circle is generally acknowledged the relatively laxative of the treatment constipation of safety, can help constipation person to set up the defecation rule.The whole enteric liquid that suitably increases polyethyleneglycol content is fit to the comparatively serious crowd of constipation.
The ossein peptide product can increase the breeding of the bacillus bifidus of human body intestinal canal self, the microecosystem regulation system, and have the effect that nutrients such as certain antioxidation and promotion calcium absorb.The Total antioxidant capacity that experimental results show that ossein peptide of the present invention is 71.92% of a glutathion (GSH).
The eliminating toxin and beautifying the skin nutrient of Aloe for generally acknowledging, obviously enhancing body toxin expelling and cleaning function can also make whole enteric liquid have better mouthfeel simultaneously.
Compared with prior art, the invention has the advantages that and selected above-mentioned various nutrients and bone collagen polypeptide powder (preferred homemade bone collagen polypeptide powder) for use, make a kind of multiple functional compound whole enteric liquid after mixing by a certain percentage.This compound whole enteric liquid can make the better collaborative performance of oligofructose, oligomeric galactose, soybean oligo saccharide, Polyethylene Glycol, ossein peptide, aloetic effect, and can be made into the compound whole enteric liquid of function differenceization by the different proportionings of regulating each component, to be applicable to different crowd.Compound whole enteric liquid of the present invention is good mouthfeel not only, and the noxious substance that is adsorbed in the intestinal is excreted, and also can promote probiotic bacteria propagation in the intestinal, regulates intestinal microbial population, loosening bowel to relieve constipation, has health care preferably.Preparation technology of the present invention is also simple relatively, easy to operate, and cost is lower, can realize the suitability for industrialized production of the compound whole enteric liquid of the present invention.
The specific embodiment
Embodiment 1:
A kind of bone collagen polypeptide composite solution for regulating intestines is formulated by the component of following quality: the drinking water of oligofructose 6kg, oligomeric galactose 6kg, soybean oligo saccharide 4kg, Polyethylene Glycol 10kg, bone collagen polypeptide powder 4kg (wherein the mass percent of polypeptide is 75%), Aloe juice 2kg and 68kg.
Above-mentioned bone collagen polypeptide composite solution for regulating intestines is to be prepared by following method: at first be ready to raw material by above-mentioned quality, ready raw material mix homogeneously is made its dissolving, filter, through 125 ℃ of high temperature sterilizes sterile filling immediately after 5 seconds.
The above-mentioned bone collagen polypeptide powder of using is to prepare by the following method: get Fresh Os Sus domestica and clean the preliminary fragmentation in back, bone piece after the fragmentation is put into boiling container, add water in the container with quality such as bone piece, steaming and decocting 50min under 110 ℃ of temperature, 143kPa pressure, remove the upper strata oils and fats then, drain, chopped obtains the bone piece of 3～4cm, dry 7h under 85 ℃ of temperature, after the drying with the bone piece through the pulverizer coarse pulverization, carry out micronizing through super micron mill again, the bone meal after the micronizing is crossed 160 mesh sieves; Bone meal after sieving is added bone mud liquid that water is mixed with 10% mass concentration packs in the container, 15min sterilizes in 85 ℃ of water-baths, be cooled to again below 40 ℃, regulate pH value to 7.5, the Protamex compound protease (Denmark Novozymes Company produce, the mark vigor is 1.5AU/g (Anson unit/gram)) that adds enzymolysis substrate bone meal quality 2 ‰ then is enzymolysis 10h under 55 ℃, the condition of pH value 7.5 in temperature, enzyme denaturing 15min in 85 ℃ of water-baths filters and collects enzymolysis solution then; Use the rotary evaporation concentrating instrument that the enzymolysis solution of collecting is concentrated into 1/4 of original volume, then concentrated solution is placed-30 ℃ of refrigerators to freeze,, collect bone collagen polypeptide powder and be stored in-24 ℃ of refrigerators again through lyophilization 24h.
The above-mentioned Aloe juice of using is that its meat obtains behind squeezing, fine straining with the Aloe peeling; The equal buyable of remaining raw material.
Embodiment 2:
A kind of bone collagen polypeptide composite solution for regulating intestines is formulated by the component of following quality: the deionized water of oligofructose 8kg, oligomeric galactose 8kg, soybean oligo saccharide 6kg, Polyethylene Glycol 12kg, bone collagen polypeptide powder 6kg (wherein the mass percent of polypeptide is 75%), Aloe juice 4kg and 56kg.
Above-mentioned bone collagen polypeptide composite solution for regulating intestines is to be prepared by following method: at first be ready to raw material by above-mentioned quality, ready raw material mix homogeneously is made its dissolving, filter, through 125 ℃ of high temperature sterilizes sterile filling immediately after 5 seconds.
The acquiring way of various raw materials and preparation method are identical with embodiment 1 in the present embodiment.
More than the product of each embodiment carry out inspection for food hygiene according to the method for stipulating among GB/T 5009.11, GB/T 5009.12, GB/T 5009.17 and the GB 4789.2-15, the result is as follows: (in AS, mg/kg), plumbous 0.35 (in Pb for inorganic arsenic 0.2, mg/kg), hydrargyrum (in Hg, mg/kg)≤0.2, total plate count (cfu/g)≤50, coliform (MPN/100g)≤40, mycete (cfu/g)≤10, yeast (cfu/g)≤10, pathogenic bacterium do not detect.Meet GB 16740-1997 health care (function) food universal standard.
Claims (7)
1. bone collagen polypeptide composite solution for regulating intestines, it is characterized in that described compound whole enteric liquid is formulated by the component of following mass fraction: 3%～28% functional oligose, 5%～15% Polyethylene Glycol, 2%～10% bone collagen polypeptide powder, 1%～5% the Aloe juice and the water of surplus;
3%～28% the functional oligose that comprises in the described compound whole enteric liquid is mixed by the soybean oligo saccharide of the oligofructose that accounts for compound whole enteric liquid mass fraction 1%～10%, 1%～10% oligomeric galactose and 1%～8% and forms;
Described bone collagen polypeptide powder is to prepare by the following method: get the Os Sus domestica bone and clean, first broken back boiling water steaming and decocting drains the bone piece and drying behind the oils and fats of removal cooking liquor top layer; Again the bone piece is carried out coarse pulverization, micronizing is made bone meal, adds water bone meal is mixed with bone mud liquid, the high temperature sterilize postcooling also adds the Protamex compound protease and carries out enzymolysis, enzyme denaturing; Get filtrate vacuum concentration and lyophilization after the filtration, obtain bone collagen polypeptide powder.
2. bone collagen polypeptide composite solution for regulating intestines according to claim 1, the mass percent that it is characterized in that polypeptide in the described bone collagen polypeptide powder is 70%～80%.
3. bone collagen polypeptide composite solution for regulating intestines according to claim 1, the water that it is characterized in that described surplus is ultrafiltration water, deionized water or drinking water.
4. preparation method as each described bone collagen polypeptide composite solution for regulating intestines in the claim 1～3 may further comprise the steps:
(1) prepares raw material: prepare required raw material, and with ready raw material by following mass fraction mix homogeneously: functional oligose 3%～28%, Polyethylene Glycol 5%～15%, bone collagen polypeptide powder 2%～10% and Aloe juice 1%～5%, surplus are ultrafiltration water, deionized water or drinking water;
(2) filtration sterilization: the mixed solution of above-mentioned preparation is filtered, and instantaneous ultrahigh-temperature sterilization obtains finished product.
5. preparation method according to claim 4, it is characterized in that: the addition of described Protamex compound protease is 2～2.5% of an enzymolysis substrate bone meal quality, pH value during described Protamex compound protease enzymolysis is 7.5, and temperature is controlled at 55 ℃, and enzymolysis time is 10～15 hours.
6. preparation method according to claim 4, it is characterized in that: during described boiling water steaming and decocting, the mass ratio of bone piece and water is 1: 1～1: 2, temperature during the boiling water steaming and decocting is controlled at 110 ℃～120 ℃, pressure during the boiling water steaming and decocting is controlled at 143kPa～198kPa, and the time of boiling water steaming and decocting is controlled at 30～60min.
7. according to each described preparation method in the claim 4～6, it is characterized in that: the temperature of described instantaneous ultrahigh-temperature sterilization is 120～130 ℃, and sterilization time is 2～8 seconds.
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| CN107912543A (en) * | 2017-11-20 | 2018-04-17 | 广州市澳万生物科技有限公司 | Fat collagen solution of suppression based on CRHD and preparation method thereof |
| CN111066991A (en) * | 2019-12-31 | 2020-04-28 | 扬州江大食生一生食品有限公司 | Preparation method of composite prebiotics solid beverage for improving gastrointestinal tract function |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1193483A (en) * | 1997-03-18 | 1998-09-23 | 徐海军 | Multi-element polypeptide nutrient and preparation thereof |
| CN1683008A (en) * | 2005-03-14 | 2005-10-19 | 山东轻工业学院 | Collagen polypeptide preparation for supplementing calcium and its preparing method |
| CN101041067A (en) * | 2006-03-24 | 2007-09-26 | 林建周 | Preparation for beauty and for adjusting the immunity |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1193483A (en) * | 1997-03-18 | 1998-09-23 | 徐海军 | Multi-element polypeptide nutrient and preparation thereof |
| CN1683008A (en) * | 2005-03-14 | 2005-10-19 | 山东轻工业学院 | Collagen polypeptide preparation for supplementing calcium and its preparing method |
| CN101041067A (en) * | 2006-03-24 | 2007-09-26 | 林建周 | Preparation for beauty and for adjusting the immunity |
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