CN113286885A - 用靶向apo(a)的经缀合的反义化合物降低心血管事件的风险的方法 - Google Patents

用靶向apo(a)的经缀合的反义化合物降低心血管事件的风险的方法 Download PDF

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CN113286885A
CN113286885A CN201980073271.0A CN201980073271A CN113286885A CN 113286885 A CN113286885 A CN 113286885A CN 201980073271 A CN201980073271 A CN 201980073271A CN 113286885 A CN113286885 A CN 113286885A
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compound
patient
administration
plasma
death
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A·列索戈尔
邵青
T·索伦
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Novartis AG
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CN201980073271.0A 2018-11-09 2019-11-08 用靶向apo(a)的经缀合的反义化合物降低心血管事件的风险的方法 Pending CN113286885A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862758323P 2018-11-09 2018-11-09
US62/758,323 2018-11-09
US201962874459P 2019-07-15 2019-07-15
US62/874,459 2019-07-15
PCT/IB2019/059632 WO2020095274A1 (en) 2018-11-09 2019-11-08 Method for reducing the risk of a cardiovascular event with conjugated antisense compounds targeting apo(a)

Publications (1)

Publication Number Publication Date
CN113286885A true CN113286885A (zh) 2021-08-20

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CN201980073271.0A Pending CN113286885A (zh) 2018-11-09 2019-11-08 用靶向apo(a)的经缀合的反义化合物降低心血管事件的风险的方法

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US (2) US20210395737A1 (enExample)
EP (1) EP3877523A1 (enExample)
JP (3) JP2022512911A (enExample)
KR (2) KR20210091703A (enExample)
CN (1) CN113286885A (enExample)
AU (3) AU2019377275A1 (enExample)
CA (1) CA3111382A1 (enExample)
IL (1) IL281147A (enExample)
WO (1) WO2020095274A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020150473A2 (en) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Pcsk9 inhibitors and methods of use thereof
BR112021013924A2 (pt) 2019-01-18 2021-09-21 Astrazeneca Ab Inibidores de pcsk9 e métodos de uso do mesmo

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599706A (en) 1994-09-23 1997-02-04 Stinchcomb; Dan T. Ribozymes targeted to apo(a) mRNA
US7227014B2 (en) 2001-08-07 2007-06-05 Isis Pharmaceuticals, Inc. Antisense modulation of apolipoprotein (a) expression
US7259150B2 (en) 2001-08-07 2007-08-21 Isis Pharmaceuticals, Inc. Modulation of apolipoprotein (a) expression
WO2003014397A1 (en) 2001-08-09 2003-02-20 Biomedlab Corporation Probe for detection of enteric virus detection kit and method for enteric virus with the same
RU2624028C2 (ru) 2012-05-24 2017-06-30 Ионис Фармасьютикалз, Инк. Способы и композиции для модулирования экспрессии аполипопротеина (а)
PL2992098T3 (pl) 2013-05-01 2019-09-30 Ionis Pharmaceuticals, Inc. Kompozycje i sposoby modulowania ekspresji hbv i ttr
WO2015168589A2 (en) * 2014-05-01 2015-11-05 Isis Pharmaceuticals, Inc. Compositions and methods for modulating angiopoietin-like 3 expression
AU2016349625B2 (en) 2015-11-06 2022-07-07 Ionis Pharmaceuticals, Inc. Modulating apolipoprotein (a) expression
LT4119569T (lt) * 2015-11-06 2024-09-25 Ionis Pharmaceuticals, Inc. Konjuguoti priešprasmiai junginiai, skirti panaudoti terapijoje

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Publication number Publication date
WO2020095274A1 (en) 2020-05-14
AU2025267467A1 (en) 2025-12-04
AU2023210550A1 (en) 2023-08-24
JP2022512911A (ja) 2022-02-07
IL281147A (en) 2021-04-29
US20260049310A1 (en) 2026-02-19
CA3111382A1 (en) 2020-05-14
JP2026021335A (ja) 2026-02-10
KR20260037169A (ko) 2026-03-17
US20210395737A1 (en) 2021-12-23
AU2019377275A1 (en) 2021-03-25
EP3877523A1 (en) 2021-09-15
JP2024081645A (ja) 2024-06-18
KR20210091703A (ko) 2021-07-22

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