CN113227075A - 用于产生n,n’-双[2-(1h-咪唑-4-基)乙基]丙二酰胺的新方法 - Google Patents

用于产生n,n’-双[2-(1h-咪唑-4-基)乙基]丙二酰胺的新方法 Download PDF

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Publication number
CN113227075A
CN113227075A CN201980086518.2A CN201980086518A CN113227075A CN 113227075 A CN113227075 A CN 113227075A CN 201980086518 A CN201980086518 A CN 201980086518A CN 113227075 A CN113227075 A CN 113227075A
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CN
China
Prior art keywords
bis
histamine
malonamide
imidazol
ethyl
Prior art date
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Pending
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CN201980086518.2A
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English (en)
Chinese (zh)
Inventor
弗拉迪米尔·叶夫根尼耶维奇·涅博利辛
塔季亚纳·亚历山德罗芙娜·克罗莫瓦
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Vladimir Yevgeniyevich Neborisin
Valenta Intellect LLC
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Pharmenterprises OOO
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Publication of CN113227075A publication Critical patent/CN113227075A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201980086518.2A 2018-10-29 2019-10-25 用于产生n,n’-双[2-(1h-咪唑-4-基)乙基]丙二酰胺的新方法 Pending CN113227075A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU2018138004A RU2679636C1 (ru) 2018-10-29 2018-10-29 Новый способ получения n,n'-бис[2-(1н-имидазол-4-ил)этил]малонамида
RU2018138004 2018-10-29
PCT/RU2019/050199 WO2020091632A1 (ru) 2018-10-29 2019-10-25 Новый способ получения n,n'-бис[2-(1н-имидазол-4-ил)этил]малонамида

Publications (1)

Publication Number Publication Date
CN113227075A true CN113227075A (zh) 2021-08-06

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CN201980086518.2A Pending CN113227075A (zh) 2018-10-29 2019-10-25 用于产生n,n’-双[2-(1h-咪唑-4-基)乙基]丙二酰胺的新方法

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CN (1) CN113227075A (ru)
EA (1) EA202191158A1 (ru)
RU (1) RU2679636C1 (ru)
WO (1) WO2020091632A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2745265C2 (ru) * 2019-09-12 2021-03-22 Общество С Ограниченной Ответственностью "Валента - Интеллект" Новые составы 2-(имидазол-4-ил)-этанамида пентандиовой-1,5 кислоты для лечения и профилактики вирусных заболеваний
WO2023224519A1 (ru) * 2022-05-19 2023-11-23 Общество С Ограниченной Ответственностью "Валента-Интеллект" Новая кристаллическая форма n,n'-бис-[2-(1н-имидазол-4-ил)этил]пропандиамида и ее фармацевтическое применение

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105358548A (zh) * 2013-04-12 2016-02-24 制药有限责任公司 二羧酸双酰胺衍生物、其用途、基于其的药物组合物和用于生产二羧酸双酰胺衍生物的方法
WO2017205622A1 (en) * 2016-05-25 2017-11-30 Savant Neglected Diseases, Llc Method of making benznidazole

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2287524C1 (ru) * 2005-03-31 2006-11-20 ООО "Фарминтерпрайсез" Аспартильные производные гистамина, способ их получения, фармацевтическая композиция и их применение в качестве модуляторов активности ферментов антиоксидантной защиты

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105358548A (zh) * 2013-04-12 2016-02-24 制药有限责任公司 二羧酸双酰胺衍生物、其用途、基于其的药物组合物和用于生产二羧酸双酰胺衍生物的方法
CN109134378A (zh) * 2013-04-12 2019-01-04 特拉米德医疗有限责任公司 二羧酸双酰胺衍生物、其用途和基于其的药物组合物
WO2017205622A1 (en) * 2016-05-25 2017-11-30 Savant Neglected Diseases, Llc Method of making benznidazole

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
项东升;: "N,N\'-二苯基丙二酰胺的合成新工艺", 化工中间体, no. 06, pages 4 - 6 *

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Publication number Publication date
RU2679636C1 (ru) 2019-02-12
WO2020091632A1 (ru) 2020-05-07
EA202191158A1 (ru) 2021-07-20

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