CN113209173A - Chinese patent medicine powder for treating nephritis and preparation method thereof - Google Patents
Chinese patent medicine powder for treating nephritis and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The Chinese patent medicine powder for treating nephritis and the preparation method thereof are characterized in that the Chinese patent medicine powder is prepared from the following raw materials in parts by weight: 10-15 parts of morinda officinalis micro powder, 8-10 parts of cistanche extract, 5-10 parts of cynomorium songaricum extract, 0.5-1 part of cinnamon oil, 15-30 parts of astragalus extract, 0.2-1 part of calculus bovis factitius and 0.6-1 part of liquorice micro powder. The Chinese patent medicine provided by the invention has a remarkable effect on treating nephritis, can be used for treating nephritis, has a stable curative effect, has no toxic or side effect, and is suitable for long-term administration, so that the Chinese patent medicine is also an ideal medicine for treating nephritis.
Description
[ technical field ] A method for producing a semiconductor device
The invention relates to the field of Chinese patent medicines, in particular to Chinese patent medicine powder for treating nephritis and a preparation method thereof.
[ background of the invention ]
The kidney is an organ that performs various functions, and is one of representative excretory organs, and functions not only as an excretory organ, regulating body fluid volume, excreting waste products, and regulating electrolyte content, but also as an endocrine organ, secreting hormones such as erythropoietin (for red blood cell production) and rennin (for blood pressure control) and regulating the metabolism of vitamin D3 to regulate parathyroid function and calcium metabolism. Moreover, the kidney also acts as a metabolic organ, destroying peptide hormones, reabsorbing low molecular weight proteins and regulating glucose/lipid metabolism. Examples of kidney diseases are nephritis, renal failure, kidney cancer, etc., with nephritis being the most typical kidney disease. At present, antibiotics are the most commonly used drugs for nephritis, and the use of immunosuppressive drugs for nephritis is also increasing in recent years. However, long-term use of immunosuppressive drugs or antibiotics leads to side effects including ulcers, edema, exacerbation of infection, hypertension, hepatotoxic disease, and the like. The Chinese patent medicine is prepared into various Chinese medicinal products of different formulations by processing Chinese herbal medicines serving as raw materials through preparations, including various formulations such as pills, powder, paste and pills, and is essence of an effective prescription created and summarized by medical scientists in the past generations of China through hundreds of years of medical practice. The Chinese patent medicine for treating nephritis aims at reducing proteinuria and controlling hematuria, promotes blood circulation, removes blood stasis, improves blood circulation, delays progressive sclerosis of glomeruli, reduces nitrogen retention, improves renal function and reduces blood creatinine. The Chinese patent medicines adopted for treating nephritis at the present stage generally comprise rare medicines such as ginseng, cordyceps sinensis and the like, and the content of effective components in the medicinal composition is low due to the large formula, so that the waste of medicinal sources and the increase of patient expenditure are caused, and the medicinal effect is not high.
Therefore, the problem to be solved in the art is to provide a preparation method of a Chinese patent medicine which reduces the cost and improves the curative effect.
[ summary of the invention ]
Aiming at the problems, the Chinese patent medicine for treating nephritis provided by the invention has a remarkable effect, can be used for treating nephritis, has a stable curative effect, has no toxic or side effect, and is suitable for long-term administration, so that the Chinese patent medicine for treating nephritis is also an ideal medicine for treating nephritis.
In order to solve the problems, the invention provides Chinese patent medicine powder for treating nephritis and a preparation method thereof, wherein the Chinese patent medicine powder is prepared from the following raw materials in parts by weight: 10-15 parts of morinda officinalis micro powder, 8-10 parts of cistanche extract, 5-10 parts of cynomorium songaricum extract, 0.5-1 part of cinnamon oil, 15-30 parts of astragalus extract, 0.2-1 part of calculus bovis factitius and 0.6-1 part of liquorice micro powder.
Further, the raw materials comprise: 13 parts of morinda officinalis micro powder, 9 parts of cistanche extract, 8 parts of cynomorium songaricum extract, 0.7 part of cinnamon oil, 20 parts of astragalus extract, 0.5 part of calculus bovis factitius and 0.8 part of liquorice micro powder.
A preparation method of Chinese patent medicine powder for treating nephritis comprises the following steps:
the method comprises the following steps: cutting radix Morindae officinalis, removing core, adding saline solution into radix Morindae officinalis, moistening, steaming under normal pressure, and drying to obtain salted radix Morindae officinalis, and pulverizing salted radix Morindae officinalis to obtain radix Morindae officinalis micropowder;
step two: placing the pretreated liquorice in ozone water for ozone sterilization, cleaning the liquorice after ozone sterilization, adding purified water for wet crushing to obtain liquorice slurry; carrying out vacuum filtration on the liquorice slurry to obtain liquorice filtered slurry; vacuum decompression concentration is carried out on the licorice root filtered pulp to obtain licorice root thick pulp; carrying out vacuum freeze drying on the obtained liquorice dense slurry to obtain liquorice micro powder;
step three: cleaning Cistanchis herba, oven drying, pulverizing, placing into continuous countercurrent ultrasonic extractor, adding ethanol water solution, performing ultrasonic countercurrent extraction, filtering the extractive solution, precipitating with ethanol for 24 hr, filtering with microporous membrane, recovering ethanol from the filtrate under reduced pressure, concentrating into fluid extract, and vacuum drying under reduced pressure;
step four: pulverizing herba Cynomorii into coarse powder, soaking in ethanol, reflux extracting, recovering ethanol from the filtrate under reduced pressure until no ethanol smell exists to obtain herba Cynomorii extractive solution, preparing dispersion with distilled water, adjusting pH, eluting with ethanol, recovering ethanol under reduced pressure, drying, and pulverizing to obtain herba Cynomorii extract;
step five: pulverizing branches and leaves of cortex Cinnamomi with pulverizer, freeze drying to obtain cortex Cinnamomi powder, soaking in saline water, distilling and condensing, and separating oil from water under vacuum and reduced pressure to obtain oleum Cinnamomi.
Step seven: the raw materials are mixed according to a certain proportion, and are crushed after vacuum freeze drying to prepare Chinese patent medicine powder.
Further, in the first step, 1.5% saline solution is adopted for moistening for 5 hours, steaming for 4 hours in a water-proof way under normal pressure, and drying for 24 hours at 50 ℃.
Further, the ozone concentration of the ozone water in the second step is 16-20mg/L, the temperature is 5-10 ℃, and the ozone sterilization time is 60-90 min.
Further, the dispersion liquid in the fourth step contains 0.3g/mL of crude drug, and has a pH value of 4.5.
Further, in the fifth step, branches and leaves of cinnamon are crushed to 40 meshes, freeze-dried for 24 hours at minus 10 ℃, soaked for 8 hours with the saline water mass concentration of 2%, distilled for 3 hours and the vacuum degree of minus 0.08 MPa.
Moreover, the Chinese patent medicine for treating nephritis provided by the invention has a remarkable effect, can be used for treating nephritis, has a stable curative effect, does not have toxic or side effect, and is suitable for long-term administration, so that the Chinese patent medicine for treating nephritis is also an ideal medicine for treating nephritis.
[ description of the drawings ]
FIG. 1 is a table of test results of the present invention.
[ detailed description ] embodiments
The invention discloses a Chinese patent medicine powder for treating nephritis and a preparation method thereof, and a person skilled in the art can realize the preparation by properly improving process parameters by referring to the content of the invention. It is expressly intended that all such similar substitutes and modifications which would be obvious to those skilled in the art are deemed to be included in the invention. While the method and application of the present invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications in the method and application described herein may be made and equivalents employed without departing from the spirit and scope of the invention.
For a further understanding of the present invention, reference will now be made in detail to the following examples.
The Chinese patent medicine powder for treating nephritis is prepared from the following raw materials in parts by weight: 10-15 parts of morinda officinalis micro powder, 8-10 parts of cistanche extract, 5-10 parts of cynomorium songaricum extract, 0.5-1 part of cinnamon oil, 15-30 parts of astragalus extract, 0.2-1 part of calculus bovis factitius and 0.6-1 part of liquorice micro powder;
morinda officinalis: is root of Morinda officinalis of Morinda of Rubiaceae, with pungent and sweet taste and mild in nature; the kidney-entering preparation mainly comprises saccharides, flavones, amino acids and the like, and also contains a small amount of anthraquinones and vitamin C, and is mainly used for treating chronic nephritis, diabetes, aldosteronism, hypothyroidism, sexual neurasthenia, adrenocortical insufficiency and climacteric syndrome with insufficiency of kidney-yang, and rheumatic arthritis and rheumatoid arthritis with wind-cold-dampness obstruction.
Cistanche deserticola: is succulent stem with scaly leaf of cistanche deserticola of cistanche of Orobanchaceae, has sweet, salty and warm property, and is effective in invigorating kidney, and contains fat-soluble components including 6-methylindole, 3-methyl-3 ethylhexane, N-dimethylglycine methyl ester and betaine. Has the effects of tonifying kidney, supporting yang, moistening intestine and relaxing bowels. Can be used for treating chronic nephritis, diabetes, aldosteronism, hypothyroidism, sexual neurasthenia, adrenocortical hypofunction, climacteric syndrome due to kidney yang deficiency, habitual constipation, senile constipation, and constipation after hemorrhoid operation due to kidney essence deficiency.
And (3) locking the positive: is succulent stem of Cynomorium songaricum of Cynomorium of Cynomoriaceae, and has sweet taste and warm nature; it enters liver and kidney. Contains flavonoid, anthocyanin and the like, terpenes, ursolic acid, acetyl ursolic acid and the like, alcohols, beta-sitosterol, campesterol and the like, and organic compounds, such as palmitic acid, oleic acid, linolenic acid and the like, has the effects of tonifying kidney and supporting yang, relaxing bowel and the like, and is mainly used for treating kidney-yang deficiency, impotence, cold sperm, liver and kidney deficiency, foot flaccidity, soft tendons, intestinal dryness and constipation and the like.
Cinnamon: the dry bark of cinnamon bark, belonging to the genus cinnamomum of the family lauraceae, is pungent, sweet and strongly hot in nature; kidney-invigorating, contains volatile oil (oleum Cinnamomi) 1.98-2.06%, cinnamaldehyde 52.92-61.20%, and cinnamyl alcohol, cinnamyl alcohol acetate, cinnamic acid, phenylpropyl acetate, coumarin, mucus, tannin, etc. Has the effects of invigorating qi, invigorating yang, consolidating superficial resistance, arresting sweating, inducing diuresis, relieving swelling, promoting fluid production, nourishing blood, removing stagnation, relieving arthralgia, removing toxic substance, expelling pus, healing sore, and promoting granulation.
Artificial bezoar: is prepared from ox gall powder, cholic acid, hyodeoxycholic acid, taurine, bilirubin, cholesterol, trace elements, etc. Has effects of clearing heart fire, eliminating phlegm, inducing resuscitation, cooling liver, calming endogenous wind, and removing toxic substance.
Licorice root: is dried root and rhizome of plant of Glycyrrhiza of Leguminosae. Has the effects of tonifying qi and strengthening the middle warmer, moistening lung for arresting cough, clearing away heat and toxic materials, relieving spasm and pain, and harmonizing drug properties.
The method comprises the following steps: preparing radix Morindae officinalis micropowder
Cutting radix Morindae officinalis into pieces of 1-1.5 cm, cleaning, adding 1.0 times of water into cleaned radix Morindae officinalis, moistening at 50 deg.C for 9h, removing core, oven drying at 50 deg.C, adding 1.5% saline solution into radix Morindae officinalis, moistening for 5h, steaming at normal pressure for 4h, taking out to obtain salted radix Morindae officinalis, and pulverizing salted radix Morindae officinalis to obtain radix Morindae officinalis micropowder.
The preparation method of the Chinese patent medicine powder comprises the following steps
Step two: preparing licorice micro powder
Cleaning and draining the licorice raw material, and airing to obtain pretreated licorice; placing the pretreated liquorice in ozone water for ozone sterilization; the ozone concentration of the ozone water is 16-20mg/L, the temperature is 5-10 ℃, and the ozone sterilization time is 60-90 min; cleaning the liquorice subjected to ozone sterilization, adding purified water, and carrying out wet grinding, wherein the mass ratio of the liquorice to the purified water is 1:7-9, so as to obtain liquorice slurry; carrying out vacuum filtration on the liquorice slurry to obtain liquorice filtered slurry; vacuum decompression concentration is carried out on the licorice root filtered pulp to obtain licorice root thick pulp; and carrying out vacuum freeze drying on the obtained liquorice dense slurry to obtain liquorice micro powder for later use.
Step three: preparation of Cistanchis herba extract
Cleaning Cistanchis herba, oven drying, pulverizing, placing into continuous countercurrent ultrasonic extractor, adding ethanol water solution, performing ultrasonic countercurrent extraction, filtering extractive solution, collecting filtrate and residue, repeating ultrasonic countercurrent extraction for 2-3 times, filtering after each extraction, mixing filtrates, concentrating under reduced pressure, recovering ethanol to obtain fluid extract with relative density of 1.05-1.25 at 60 deg.C; precipitating with ethanol for 24 hr, filtering with microporous membrane, recovering ethanol from the filtrate under reduced pressure, concentrating to obtain fluid extract with relative density of 1.20-1.30 at 60 deg.C, and vacuum drying under reduced pressure to obtain Cistanchis herba extract.
Step four: preparation of Cynomorium songaricum extract
Pulverizing herba Cynomorii into coarse powder, soaking in ethanol, reflux extracting, and recovering ethanol from the filtrate under reduced pressure to obtain herba Cynomorii extractive solution; dispersing the herba Cynomorii extractive solution with distilled water to obtain dispersion containing crude drug 0.3g/mL, adjusting pH to 4.5, loading onto macroporous adsorbent resin column, eluting with distilled water, and discarding eluate; eluting with 10% ethanol, and discarding eluate; then eluting with 30% ethanol, collecting 30% ethanol eluate, recovering ethanol under reduced pressure, drying, and pulverizing to obtain herba Cynomorii extract.
Step five: preparation of cinnamon oil
Pulverizing branches and leaves of cortex Cinnamomi to 40 mesh with pulverizer; then freeze-drying at-10 deg.C for 24 hr to obtain frozen cortex Cinnamomi powder; putting cinnamon powder into saline water with the mass concentration of 2% to be soaked for 8 hours; filtering, putting the cinnamon powder into a distillation retort, introducing steam for distillation for 3 hours to obtain mixed steam: condensing the obtained mixed steam by a condenser, and then carrying out oil-water separation by an oil-water separator to obtain crude cinnamon oil; and distilling the crude cinnamon oil under vacuum degree of-0.08 Mpa and temperature of 90 deg.C under reduced pressure to remove water to obtain pure cinnamon oil.
Step six: preparation of Astragalus extract
Taking dried radix astragali raw material, cleaning, drying, pulverizing, adding water, heating, boiling and extracting for three times, each time for 2 hours, combining three extracting solutions, concentrating and evaporating water to obtain an extract with the specific gravity d of 1.20, standing, cooling, adding ethanol into the extract, stirring until the ethanol content is 60%, standing, precipitating, filtering, concentrating, recovering ethanol, and drying by air blast or vacuum to obtain the radix astragali extract.
Step seven: preparing Chinese patent medicine powder according to the proportion
Mixing the above radix Morindae officinalis micropowder, Glycyrrhrizae radix micropowder, Cistanchis herba extract, herba Cynomorii extract, oleum Cinnamomi, and radix astragali extract at a certain proportion, vacuum freeze drying, and pulverizing to obtain Chinese medicinal powder.
Experimental example: clinical efficacy test
Out of 60 cases in outpatient or ward, 30 men and 30 women were selected; the age is 6-33 years, and the average age is 15.6 years; the course of the disease is 1-10 days. (1) Meets the diagnosis standard of acute nephritis published by the State administration of traditional Chinese medicine (clinical research guide principles of new Chinese medicines); (2) the course of the disease is within 10 days; (3) excluding patients with severe renal function impairment; (4) excluding other kidney diseases; (5) the patients who can not take the traditional Chinese medicine are excluded. (5) The patient dialectically conforms to the characteristics of kidney deficiency and blood stasis.
The therapeutic effect judgment standard is as follows:
and (3) healing: edema and other symptoms and related signs basically disappear, urine protein examination is continuously negative, the quantitative quantity of urine protein lasts less than 0.3g in 24 hours, and the kidney function is normal.
The effect is shown: the symptoms such as edema and the like and related signs basically disappear, the urine protein examination is continuously reduced by more than 50 percent, and the renal function is normal or basically normal.
The method has the following advantages: symptoms such as edema and related signs are obviously improved, urine protein examination is continuously reduced by one plus sign, or the quantitative urine protein is continuously reduced by more than 25 percent in 24 hours.
And (4) invalidation: no significant improvement or aggravation of clinical manifestations or laboratory examinations.
The therapeutic results are shown in FIG. 1
The results show that the protein ration of the treatment group in 24 hours is far lower than that of the control group, the Chinese patent medicine for treating nephritis provided by the invention has a remarkable effect, can be used for treating nephritis, has stable curative effect and no toxic or side effect, and is suitable for long-term administration, so that the Chinese patent medicine for treating nephritis is also an ideal medicine for treating nephritis.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (7)
1. The Chinese patent medicine powder for treating nephritis is prepared from the following raw materials in parts by weight: 10-15 parts of morinda officinalis micro powder, 8-10 parts of cistanche extract, 5-10 parts of cynomorium songaricum extract, 0.5-1 part of cinnamon oil, 15-30 parts of astragalus extract, 0.2-1 part of calculus bovis factitius and 0.6-1 part of liquorice micro powder.
2. The method for preparing Chinese patent medicine powder for treating nephritis according to claim 1, wherein the raw materials comprise: 13 parts of morinda officinalis micro powder, 9 parts of cistanche extract, 8 parts of cynomorium songaricum extract, 0.7 part of cinnamon oil, 20 parts of astragalus extract, 0.5 part of calculus bovis factitius and 0.8 part of liquorice micro powder.
3. A method for preparing a Chinese patent medicine powder as claimed in claim 1, which comprises the following steps:
the method comprises the following steps: cutting radix Morindae officinalis, removing core, adding saline solution into radix Morindae officinalis, moistening, steaming under normal pressure, and drying to obtain salted radix Morindae officinalis, and pulverizing salted radix Morindae officinalis to obtain radix Morindae officinalis micropowder;
step two: placing the pretreated liquorice in ozone water for ozone sterilization, cleaning the liquorice after ozone sterilization, adding purified water for wet crushing to obtain liquorice slurry; carrying out vacuum filtration on the liquorice slurry to obtain liquorice filtered slurry; vacuum decompression concentration is carried out on the licorice root filtered pulp to obtain licorice root thick pulp; carrying out vacuum freeze drying on the obtained liquorice dense slurry to obtain liquorice micro powder;
step three: cleaning Cistanchis herba, oven drying, pulverizing, placing into continuous countercurrent ultrasonic extractor, adding ethanol water solution, performing ultrasonic countercurrent extraction, filtering the extractive solution, precipitating with ethanol for 24 hr, filtering with microporous membrane, recovering ethanol from the filtrate under reduced pressure, concentrating into fluid extract, and vacuum drying under reduced pressure;
step four: pulverizing herba Cynomorii into coarse powder, soaking in ethanol, reflux extracting, recovering ethanol from the filtrate under reduced pressure until no ethanol smell exists to obtain herba Cynomorii extractive solution, preparing dispersion with distilled water, adjusting pH, eluting with ethanol, recovering ethanol under reduced pressure, drying, and pulverizing to obtain herba Cynomorii extract;
step five: pulverizing branches and leaves of cortex Cinnamomi with pulverizer, freeze drying to obtain cortex Cinnamomi powder, soaking in saline water, distilling and condensing, and separating oil from water under vacuum and reduced pressure to obtain oleum Cinnamomi.
Step seven: the raw materials are mixed according to a certain proportion, and are crushed after vacuum freeze drying to prepare Chinese patent medicine powder.
4. The method for preparing Chinese patent medicine powder according to claim 3, wherein 1.5% saline solution is adopted in the first step for moistening for 5h, steaming for 4h in water at normal pressure, and drying for 24h at 50 ℃.
5. The method for preparing Chinese patent medicine powder according to claim 3, wherein the ozone concentration of the ozone water in the second step is 16-20mg/L, the temperature is 5-10 ℃, and the ozone sterilization time is 60-90 min.
6. The method for preparing Chinese patent medicine powder according to claim 3, wherein the dispersion liquid in the fourth step contains 0.3g/mL of crude drug, and has a pH of 4.5.
7. The method for preparing Chinese patent medicine powder according to claim 3, wherein branches and leaves of cinnamon in the fifth step are pulverized to 40 meshes, and the powder is freeze-dried for 24 hours at-10 ℃, soaked for 8 hours with saline water mass concentration of 2%, distilled for 3 hours and vacuum degree of-0.08 Mpa.
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| CN103933296A (en) * | 2014-04-23 | 2014-07-23 | 逄海玲 | Traditional Chinese medicine for treating chromic glomerulonephritis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103933296A (en) * | 2014-04-23 | 2014-07-23 | 逄海玲 | Traditional Chinese medicine for treating chromic glomerulonephritis |
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| Title |
|---|
| 王亚威等: "经典法则对肾性水肿临床应用举隅", 《河北中医》 * |
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Application publication date: 20210806 |