CN113207717B

CN113207717B - Aseptic isolator for experimental animals

Info

Publication number: CN113207717B
Application number: CN202110579695.3A
Authority: CN
Inventors: 潘超敏; 拜小枫; 谭验; 尹意铭
Original assignee: Shenzhen Jingtuo Biotechnology Co ltd
Current assignee: Shenzhen Jingtuo Biotechnology Co ltd
Priority date: 2021-05-26
Filing date: 2021-05-26
Publication date: 2022-06-28
Anticipated expiration: 2041-05-26
Also published as: CN113207717A

Abstract

The invention discloses a sterile isolator for experimental animals; comprises an isolation bag for isolating the external environment, an air supply device for providing clean air for the isolation bag and a feeding and discharging disinfection device for automatically disinfecting materials entering and exiting the isolation bag; the feeding and discharging disinfection device is used for dynamically sealing the shell in a partitioning manner through a rotor rotatably mounted on the shell, a carrier body is arranged in a sealed space, and the rotor drives the carrier body to rotate so as to transfer materials between a feeding port and a discharging port; the rotor cooperates with the disinfectant nozzle to operate in a linkage manner in the rotating process, so that the automatic transfer and disinfection of the materials entering and exiting the isolation package are realized. Carry out the subregion through the rotor and seal and transport the disinfection to the material in sealed area to the casing, realized that the material is transported and sterile automation, improved material and shifted disinfection efficiency, avoided simultaneously among the manual operation process because of the misoperation causes the isolation package to leak the pollution, improved the disinfection reliability.

Description

Aseptic isolator for experimental animals

Technical Field

The invention relates to the field of experimental aseptic animal breeding, in particular to an aseptic isolator for experimental animals.

Background

The aseptic isolator is a key device applied to the field of aseptic animal cultivation, creates an aseptic growth environment isolated from the external complex environment for the cultivation of aseptic animals in a physical isolation mode, and avoids the interference of pathogens, bacteria and the like in the external environment on the growth of the aseptic animals; the aseptic isolator needs to disinfect all articles entering the interior of the isolator from the outside, but the existing aseptic isolator material inlet and outlet disinfection device needs to manually seal a partition plate between a disinfection channel and an isolation bag to isolate the isolation bag from the disinfection device, then a disinfection cover body on the outer side of the disinfection channel is manually taken down, the articles are placed in the disinfection channel, then an outer cover is covered on the disinfection channel, disinfection liquid is manually sprayed on the articles in the disinfection channel for disinfection, and after the disinfection is finished, the partition plate is opened to send the articles into the isolation bag; the operation is also needed when the articles are taken out from the isolation bag, because the disinfection process is completely operated manually, the isolation bag needs to be sealed and unsealed, the process is complex, the nonstandard operation easily causes incomplete disinfection of the articles or incomplete sealing of the isolation bag, so that external pathogens and bacteria enter the isolation bag, and the aseptic animals receive external microbial pollution; therefore, it is necessary to develop an automatic feeding and discharging sterilizing sterile isolator for laboratory animals, which is simple in operation, efficient, convenient, safe and reliable in sterilization.

Disclosure of Invention

The invention aims to overcome the defects and provide a sterile isolator for experimental animals.

In order to achieve the purpose, the invention adopts the following specific scheme:

an aseptic isolator for experimental animals comprises an isolation bag used for isolating the external environment, an air supply device used for providing clean air for the isolation bag and a feeding and discharging disinfection device used for automatically disinfecting materials which enter and exit the isolation bag;

the feeding and discharging disinfection device comprises a first shell and a second shell which are used for forming a cylindrical closed space; the first shell and the second shell are internally provided with a sealing material moving device in a rotating way for conveying materials; the sealing material moving device comprises a carrier body for loading materials, a rotor for transferring the materials, a disinfectant nozzle for spraying disinfectant to the surface of the materials and a liquid distributing pipe for controlling the opening and closing time of the disinfectant nozzle; the rotor is of a revolving body structure, and a plurality of partition plates used for forming a sealed space with the first shell and the second shell are axially arranged.

Furthermore, connecting arms with the length of A are symmetrically and fixedly arranged on two sides of the carrier body; the axis of the connecting arm is parallel to the bottom surface of the carrier body; the other end of the connecting arm is also rotatably provided with a roller for guiding the carrier body; the inner sides of the bottom surfaces of the first shell and the second shell are provided with first guide grooves for guiding the rollers; the first guide groove is circular and has a radius r; the center of the first guide groove is horizontal to a connecting line of the centers of the first shell; the circle center of the first guide groove deviates to the feeding side by a distance B; the turning radius of the hinge point of the carrier body is R; the annular guide groove needs to satisfy the following relationship: b = A, R = R, in order to guarantee the carrier body puts the object plane and is in the horizontality in the arbitrary position.

The invention further provides a first groove used for being connected with the partition plate on the rotor is formed in the inner side of the C-shaped surface of the sealing strip; a second guide groove is formed in the contact surface of the sealing strip with the bottom surfaces of the first shell and the second shell; the sliding block is slidably sleeved in the second guide groove; a second hinge hole is formed in the middle of the sliding block, and a second hinge shaft matched with the second hinge hole is arranged on the end face of one side of the sliding sealing block; the sliding sealing block is embedded in the first guide groove in a sliding sleeve mode and is connected with the first guide groove in an airtight mode.

The liquid pipe fixing seat is fixedly arranged on the outer side of the bottom surface of the first shell; the liquid distributing pipe is fixedly arranged on the end surface of the bottom of the liquid pipe fixing seat; the liquid distribution pipe is inserted into the second mounting hole and sealed with the inner wall of the second mounting hole; the liquid separation pipe is of a hollow tubular structure, and a liquid separation groove for discharging disinfectant is formed in the cylindrical surface; the liquid dividing tank is vertically downward, and the liquid discharge width is less than 45 degrees.

Further, the number of the carriers is 2, the matched disinfection nozzles are 2 groups and are symmetrically distributed on the rotor.

Further, the air supply device comprises a first air inlet filter, a second air inlet filter, a throttle valve, a frame, a first exhaust filter, a second exhaust filter, a primary filter, a fan, a top plate and a bottom plate; the bottom plate is fixedly connected to the frame, and the primary filter is fixedly connected to the bottom surface of the bottom plate; the fan is fixedly connected to the primary filter, and an air outlet of the fan is communicated with an air inlet of the primary filter; the first air inlet filter and the first exhaust filter are fixedly connected to the upper surface of the bottom plate, and the second air inlet filter and the second exhaust filter are fixedly connected to the top plate; and the first air inlet filter air inlet and the primary filter air outlet are communicated with the second air inlet filter air inlet and the first air inlet exhaust outlet through the throttle valve.

Further, the isolation comprises a bag body, long-sleeve gloves and a temperature and humidity sensor; the long-sleeved gloves are fixedly and airtightly connected to the front surface of the bag body, and the temperature and humidity sensor is fixedly and airtightly connected to the lower position of the middle part of the back surface of the bag body; the middle part of the back of the bag body is also provided with a connecting window used for being in airtight connection with the feeding and discharging disinfection device, and the left side of the connecting window is provided with an exhaust hole used for being connected with a first exhaust filter; and an air inlet hole for connecting the first air inlet filter is formed in the right side of the connecting window.

The invention further discloses that the isolation bags, the feeding and discharging disinfection devices and the air supply devices are in a bilaterally symmetrical distribution structure, two sets of isolation bags and the feeding and discharging disinfection devices are symmetrically arranged on the bottom plate and the top plate, and the opening and closing states of the air supply are controlled by the throttle valve between the upper layer and the lower layer.

The invention has the beneficial effects that: the invention divides the closed cylindrical surface formed by the shell of the feeding and discharging disinfection device into a plurality of closed spaces by the partition board arranged on the rotor, and performs dynamic sealing; meanwhile, a carrier body for feeding and discharging is arranged in the closed space, and a disinfectant nozzle is arranged in the rotor, so that the rotor automatically carries the materials put into the carrier to the closed space for disinfection when rotating under the driving of a motor, and then carries the materials to a discharging area communicated with the isolation bag after the disinfection. Through the feeding and discharging disinfection device, materials are automatically disinfected and transferred in and out of the isolation bag, manual intervention is not needed, and the operation is simple; meanwhile, the rotary sealing structure is reliable in sealing, and the phenomenon that external pathogens enter the isolation bag to pollute the environment in the isolation bag due to the fact that the traditional manual feeding and discharging disinfection is carried out when the disinfection channel is opened and closed because of operation irregularity can be avoided.

Drawings

FIG. 1 is a perspective view of the present invention;

FIG. 2 is a diagram of an isolated packet of the present invention;

FIG. 3 is a diagram of a gas supply apparatus of the present invention;

FIG. 4 is a perspective view of the feed and discharge sanitizing device of the present invention;

FIG. 5 is a cross-sectional view of the feed and discharge sterilizing unit of the present invention;

FIG. 6 is an enlarged view of a portion of FIG. 5 at I;

FIG. 7 is a perspective view of the sealing and material-moving device of the present invention;

FIG. 8 is a perspective view of a rotor in half section of the present invention;

FIG. 9 is an exploded view of the composite seal;

FIG. 10 is a perspective view of the carrier of the present invention;

FIG. 11 is a top view of the vehicle guide mechanism of the present invention;

FIG. 12 is a perspective view of the distributor tube of the present invention;

description of reference numerals: 1. a gas supply device; 2. isolating the package; 3. a feed and discharge sterilizing device; 11. a first intake air filter; 12. a second intake filter; 13. a frame; 14. a first exhaust gas filter; 15. a primary filter; 16. a fan; 17. a second exhaust gas filter; 18. a base plate; 19. a top plate; 110. a throttle valve; 21. a bag body; 21a, an exhaust hole; 21b, an air inlet hole; 21c, a connection window; 22. a long-sleeved glove; 23. a temperature and humidity sensor; 31. a first housing; 31a, a first mounting hole; 31b, a first guide groove; 32. sealing the material moving device; 321. a rotor; 321a, a first annular groove; 321b, a partition plate; 321c, a first through hole; 321d, a second mounting hole; 321e, a journal; 321f, a first plane; 321g, a third mounting hole; 322. a sealing strip; 322a, a second guide groove; 322b, a first groove; 323. a carrier body; 323a, a first hinge shaft; 323b, air holes; 324. a disinfectant nozzle; 325. a first bracket; 325a, a first hinge hole; 326. a connecting arm; 327. a roller; 328. sliding the sealing block; 328a, a second hinge shaft; 329. a liquid separating pipe; 329a and a liquid inlet hole; 329b, a liquid separating groove; 3210. an end face seal ring; 3211. a slider; 3211a, a second hinge hole; 33. a liquid pipe fixing seat; 34. a second bracket; 35. a third support; 36. a motor; 37. a second housing.

Detailed Description

The present invention will be described in further detail with reference to the drawings and specific examples, which should not be construed as limiting the scope of the invention.

As shown in fig. 1 to 12, the sterile isolator for experimental animals according to the present embodiment includes an isolation bag 2 for isolating an external environment, an air supply device 1 for providing clean air to the isolation bag 2, and a feeding and discharging disinfection device 3 for automatically disinfecting materials in and out of the isolation bag 2;

the feeding and discharging disinfection device comprises a first shell 31 and a second shell 37 which are used for forming a cylindrical closed space; the first shell 31 and the second shell 37 are internally provided with a sealed material moving device 32 for conveying and disinfecting materials in a rotating way; the sealing material moving device 32 comprises a carrier body 323 for loading materials, a rotor 321 for transporting materials, a disinfectant nozzle 324 for spraying disinfectant to the surfaces of the materials, and a liquid separating pipe 329 for controlling the opening and closing time of the disinfectant nozzle 324; the rotor 321 is a solid-of-revolution structure, and a plurality of partition plates 321b for forming a sealed space with the first casing 31 and the second casing 37 are axially disposed.

Specifically, the feeding and discharging disinfection device 3 further comprises a motor 36 for driving the rotor 321 to rotate, a second bracket 34 fixedly mounted on the first housing 31 for fixing the liquid distribution pipe 329, and a third bracket 35 fixedly mounted on the second housing 37 for fixing the motor 36; a second bracket 34 for supporting the first shell 31 and the second shell 37 is fixedly arranged on the side surfaces of the first shell 31 and the second shell 37;

Specifically, the sealing and moving device 32 further includes a sealing strip 322 fixedly mounted on the edge of the partition 321b and in contact sealing with the first shell 31 and the second shell 37, a first bracket 325 for hinge-supporting the carrier body 323, and an end-face sealing ring 3210 for sealing the rotor 321 with the bottom faces of the first shell 31 and the second shell 37; the first shell 31 and the second shell 37 are symmetrical cylindrical structures, and the center positions of the bottom surfaces of the first shell 31 and the second shell 37 are both provided with a first mounting hole 31a for mounting the sealing material moving device 32; the circumferential surfaces of the first shell 31 and the second shell 37 are provided with a feed inlet and a discharge outlet for feeding and discharging materials in an opposite way; the end faces of the first shell 31 and the second shell 37 are butted to form a closed cylindrical space;

specifically, the rotor 321 is rotatably mounted in the first mounting holes 31a of the first housing 31 and the second housing 37 through journals 321e at both ends of the main body; four groups of partition plates 321b are uniformly distributed on the outer side of the main body, and sealing strips 322 which are contacted with the cylindrical surface and the end surface of the closed space are fixedly arranged on the edges of the partition plates 321 b; the sealing strip 322 is of a C-shaped structure, and is simultaneously contacted with the bottom surface of the inner cylindrical surface shell of the cylindrical closed space to realize the separation and sealing of the cylindrical space; a first annular groove 321a for installing an end face seal ring 3210 is symmetrically formed in the side surface of the main body of the rotor 321, and the end face seal ring 3210 is installed in the first annular groove 321a and is in contact sealing with the bottom surfaces of the first shell 31 and the second shell 37; a plurality of first planes 321f for mounting the first support 325 are arranged on the outer side surface of the rotor 321 main body; the first plane 321f is located in the region between the two adjacent partitions 321 b; the outer sides of the vertical surfaces at the two ends of the carrier body 323 are symmetrically provided with first hinge shafts 323a, and the bottom of the carrier body is provided with a plurality of air holes 323b for discharging disinfectant; the first support 325 is of a symmetrical structure in a shape of Chinese character 'ao', and first hinge holes 325a for being matched with the first hinge shafts 323a are symmetrically formed at the top ends of the vertical surfaces at the two sides of the first support; the first bracket 325 is fixedly mounted on the first plane 321 f; a second mounting hole 321d for mounting the liquid separating pipe 329 is formed in the center of the rotor 321; a plurality of first through holes 321c for installing the disinfectant nozzle 324 are formed around the second installation hole 321 d; a plurality of disinfectant nozzles 324 for atomizing the disinfectant liquid in the second mounting hole 321d are mounted in the first through hole 321 c; a third mounting hole 321g fixedly connected with the output end of the motor 36 is further formed at one side of the main body of the rotor 321.

The specific working mode of the embodiment is as follows: keep apart the air inlet of package 2 with air feeder 1's air supply mouth intercommunication, the gas vent communicates with air feeder 1's gas vent, business turn over material degassing unit 3's discharge gate with keep apart the fixed airtight connection of package 2. When the device works, the motor 36 drives the rotor 321 to rotate anticlockwise, the carrier body 323 hinged on the first support 325 keeps in a horizontal state under the action of self gravity, when the rotor 321 carries the carrier body 323 to rotate to a feed inlet position, materials needing to be placed into the isolation bag 2 are placed on the carrier body 323 manually, and the positions of the materials are adjusted, so that the weight of the materials on the carrier body 323 is uniformly distributed, and the situation that the materials slide and are stacked to cause incomplete disinfection due to the fact that the carrier body 323 deflects in the movement process is prevented. After the materials are placed, the rotor 321 continues to rotate counterclockwise, and when the sealing strips 322 of the partition plate 321b on the upper side of the carrier body 323 rotate to the lower edge of the feed inlet, sealing areas are formed between the sealing strips 322 of the partition plate 321b on the upper side and the lower side of the carrier body 323 and the shell. The carrier body 323 carrying the material is positioned in the sealing area; after sealing, the external high-pressure disinfectant enters the second mounting hole 321d through the pipeline and enters the disinfectant nozzle 324 through the first through hole 321c to be atomized and sprayed out, so as to disinfect the material on the carrier body 323. Along with the rotation of the rotor 321, the sealing strip 322 of the front side partition 321b exceeds the lower edge of the discharge hole, the sealing space is opened to be communicated with the space in the isolation bag 2, the spray disinfection of the disinfectant nozzle 324 is stopped, and the rotor 321 is continuously rotated anticlockwise until the carrier body 323 is positioned at the discharge hole. Then, manually taking out the materials on the carrier body 323 from the bag body 21 through a discharge hole and transferring the materials into the bag body 21, placing the materials needing to be transferred out of the bag body 21 in the bag body 21 on the carrier body 323, keeping the rotor 321 rotating anticlockwise for the transported materials which do not need to be disinfected, and directly transporting the materials to the discharge hole from the upper half area by the carrier body 323 without being disinfected; for the transported materials needing to be disinfected, the rotor 321 changes the rotating direction to be clockwise, the carrier body 323 carries the materials, the materials are disinfected by the disinfection nozzle in the lower half area and then transported to the discharge port, and the materials are manually taken out of the carrier body 323.

In the embodiment, the closed cylindrical surface formed by the shell is divided into a plurality of closed spaces by the partition boards 321b arranged on the rotor 321, the carrier body 323 is arranged in the closed spaces, and the sterilizing nozzles rotating along with the rotor 321 are arranged in the area where the carrier body 323 is arranged on the rotor 321, so that automatic rotary material transportation and sterilization are realized, the working efficiency is high, the operation is simple and convenient, the sealing reliability is good, and the leakage pollution of the isolation bag 2 caused by artificial reasons can be prevented. Meanwhile, the included angle between the disinfection nozzle and the carrier body 323 is gradually changed in the motion process of the carrier body 323, so that the disinfection nozzle sprays and disinfects materials in all directions, the spraying is more uniform, and the disinfection is more thorough.

Based on the above embodiment, further, the two sides of the carrier body 323 are symmetrically and fixedly installed with the connecting arms 326 with the length a; the axis of the connecting arm 326 is parallel to the bottom surface of the carrier body 323; the other end of the connecting arm 326 is also rotatably provided with a roller 327 for guiding the carrier body 323; a first guide groove 31b for guiding the roller 327 is formed on the inner side of the bottom surfaces of the first shell 31 and the second shell 37; the first guide groove 31b is circular and has a radius r; the connection line between the circle center of the first guide groove 31b and the circle center of the first shell 31 is kept horizontal; the circle center of the first guide groove 31B deviates to the feeding side by a distance B; the turning radius of the hinge point of the carrier body 323 is R; the annular guide groove needs to satisfy the following relationship: b = A, R = R, in order to guarantee the carrier body 323 puts the object plane to be in the horizontality in the arbitrary position.

The specific working mode of the embodiment is as follows: connecting arms 326 parallel to the axis of the carrier body 323 are fixedly mounted on two sides of the carrier body 323 through first hinge shafts 323 a; the front end of the connecting arm 326 is hinged with a roller 327 for guiding the carrier body 323; the roller 327 is sleeved in the first guide groove 31b, and a parallelogram structure is formed between a connecting line of the rotation center of the first bracket 325, the connecting arm 326, the rotor 321 and the circle center of the first guide groove 31b and a connecting line between the circle center of the roller 327 and the circle center of the first guide groove 31b in the movement process; because the connecting line between the rotation axis of the rotor 321 and the center of the circle of the first guide groove 31b is always in the horizontal state in the rotation process of the rotor 321, and the opposite side, namely the connecting arm 326, is also in the horizontal state, the carrier body 323 is in the horizontal state when moving to any position along with the rotor 321, and the phenomenon that the objects are accumulated on the lower side due to the fact that the centers of the objects on the carrier body 323 are unevenly distributed and incline in the object transfer process is avoided, so that incomplete disinfection is caused.

Further, a first groove 322b for connecting with a partition 321b on the rotor 321 is arranged on the inner side of the profile of the sealing strip 322C; a second guide groove 322a is arranged on the contact surface of the sealing strip 322 with the bottom surfaces of the first shell 31 and the second shell 37; the sliding block 3211 is slidably inserted into the second guide groove 322 a; a second hinge hole 3211a is formed in the middle of the sliding block 3211, and a second hinge shaft 328a for engaging with the second hinge hole 3211a is formed in an end surface of one side of the sliding seal block 328; the sliding seal block 328 is slidably inserted into the first guide groove 31b and is hermetically connected to the first guide groove 31 b.

The working mode of the embodiment is as follows: when the C-shaped sealing strip 322 rotates along with the partition 321B of the rotor 321, the sliding block 3211, which is slidably sleeved in the second guide groove 322a, drives the sliding seal block 328 hinged thereon to rotate, and since the sliding seal block 328 is sleeved in the first guide groove 31B, and there is an offset B between the first guide groove 31B and the rotation axis of the rotor 321, the sliding block 3211 slides in the second guide groove 322a during the rotation of the rotor 321, and the stroke thereof is B, and drives the sliding seal block 328 to slide along the first guide groove 31B, thereby performing sliding seal on the sliding seal block.

The sliding sealing block 328 is hinged to the sliding block 3211 sleeved on the side surface of the sealing strip 322, and the offset B of the first guide groove 31B is compensated through the sliding block 3211 when the rotor 321 rotates, so that the rotor 321 is used for combined sealing of the first guide groove 31B and the inner surface of the shell, the sealing performance between the rotor 321 and the shell is ensured, and the leakage pollution of the isolation bag 2 is prevented.

Based on the above embodiment, further, the liquid pipe fixing seat 33 is further fixedly installed outside the bottom surface of the first housing 31; the liquid distribution pipe 329 is fixedly arranged on the end surface of the bottom of the liquid pipe fixing seat 33; the liquid separating pipe 329 is inserted into the second mounting hole 321d and sealed with the inner wall of the second mounting hole 321 d; the liquid separating pipe 329 is of a hollow tubular structure, and a liquid separating groove 329b for discharging disinfectant is formed in the cylindrical surface; the liquid separating groove 329b is vertically downward, and the liquid discharge width is less than 45 degrees.

The working mode of the embodiment is as follows: when the rotor 321 rotates, the second mounting hole 321d rotates along with the rotor 321, when the partition 321b on the rotor 321 is shifted to the lower edge of the feed inlet, the two partitions 321b on the front and the back of the carrier body 323 and the shell form a closed space, the second mounting hole 321d is communicated with the liquid separating groove 329b of the liquid separating pipe 329, and the high-pressure disinfectant in the liquid separating pipe 329 enters the disinfectant nozzle 324 through the second mounting hole 321d to be atomized and sprayed out to disinfect the objects to be disinfected on the carrier body 323; before the rotor 321 rotates to a position where the front side exceeds the lower edge of the discharge port to open the closed space, the second mounting hole 321d is disconnected from the liquid dividing groove 329b, and the disinfectant nozzle 324 stops spraying disinfectant on the objects to be disinfected. Through the cooperation of liquid separation groove 329b and third mounting hole 321g position, realize that the nozzle carries out automatic switching according to carrier body 323 position to treat that the disinfection article spray the disinfection, need not to set up controlling means alone, simplified the structure, improved the reliability.

Based on the above embodiment, specifically, the number of the carriers is 2, and the matched disinfection nozzles are 2 groups and are symmetrically distributed on the rotor 321.

In this embodiment, the first supports 325 are symmetrically and fixedly mounted on two first planes 321f opposite to the rotor 321, and the two groups of first supports 325 are respectively hinged with the carrier body 323; the rotor 321 is symmetrically provided with a plurality of second mounting holes 321d corresponding to the carrier body 323, and a plurality of disinfectant nozzles 324 are fixedly mounted in the plurality of second mounting holes 321 d. Set up two sets of carriers through the symmetry, when the article of carrying out need not the disinfection from keeping apart 2 in the package, can be so that the feeding disinfection can go on simultaneously with the ejection of compact, can effectively improve article transportation disinfection efficiency when article shift in need a large amount of 2 interior articles to keeping apart.

Based on the above embodiment, further, the air supply device 1 includes the first intake filter 11, the second intake filter 12, the throttle valve 110, the frame 13, the first exhaust filter 14, the second exhaust filter 17, the primary filter 15, the fan 16, the ceiling 19, and the floor 18; the bottom plate 18 is fixedly connected to the frame 13, and the primary filter 15 is fixedly connected to the bottom surface of the bottom plate 18; the fan 16 is fixedly connected to the primary filter 15, and an air outlet of the fan is communicated with an air inlet of the primary filter 15; the first air intake filter 11 and the first exhaust filter 14 are fixedly connected to the upper surface of the bottom plate 18, and the second air intake filter 12 and the second exhaust filter 17 are fixedly connected to the top plate 19; the inlet of the first air inlet filter 11 is communicated with the outlet of the primary filter 15, and the inlet of the second air inlet filter 12 is communicated with the outlet of the first air inlet through the throttle valve 110.

In this embodiment, air is sucked and pressurized by the fan 16, enters the primary filter 15 through the air outlet to be primarily filtered to remove suspended particles in the air, then enters the first air inlet filter 11 through the primary filter 15 pipeline to be filtered, enters the lower isolation bag 2 to be internally circulated, is filtered by the first exhaust filter 14, and is exhausted; the other part of the air enters the second air inlet filter 12 on the upper layer through the throttle valve 110, is filtered, enters the upper layer isolation bag 2 for internal circulation, is filtered by the second exhaust filter 17 and is exhausted. Through two-stage filtration, pollutants such as suspended particles, pathogens and the like in the air are effectively removed, and the cleanliness of the air in the isolation bag 2 is ensured; meanwhile, a throttle valve 110 is arranged on the air inlet side of the isolation bag 2 and can be selectively opened or closed according to the use condition of the isolation bag 2, so that energy consumption is reduced.

Based on the above embodiment, further, the isolation bag 2 includes a bag body 21, a long-sleeve glove 22 and a temperature and humidity sensor 23; the long-sleeve gloves 22 are fixedly and airtightly connected to the front side of the bag body 21, and the temperature and humidity sensor 23 is fixedly and airtightly connected to the lower position of the middle part of the back side of the bag body 21; the middle part of the back surface of the bag body 21 is also provided with a connecting window 21c which is used for being connected with the feeding and discharging disinfection device 3 in an airtight way, and the left side of the connecting window 21c is provided with an exhaust hole 21a which is used for being connected with a first exhaust filter 14; an air inlet hole 21b for connecting the first air inlet filter 11 is arranged at the right side of the connecting window 21 c.

In this embodiment, during operation, clean air provided by the air supply device 1 is injected into the bag body 21 through the air inlet 21b, and is exhausted from the air outlet 21a after circulating in the bag body 21, and the temperature and humidity sensor 23 arranged on the back surface of the bottom protection can monitor the temperature and humidity of air inside the bag body 21 and other parameters to ensure that the environment inside the bag body 21 is proper; when the materials in the bag body 21 need to be transferred, the articles to be transferred are manually taken out or put in the feeding and discharging disinfection device 3 through the long-sleeve gloves 22 arranged on the front side.

In this embodiment, furthermore, the isolation bag 2, the feeding and discharging disinfection device 3, and the air supply device 1 are in a bilateral symmetry distribution structure, two sets of isolation bags 2 and feeding and discharging disinfection devices 3 are symmetrically arranged on the bottom plate 18 and the top plate 19, and the opening and closing states of the air supply are controlled by the throttle valve 110 between the upper layer and the lower layer.

In this embodiment, four sets of bilateral symmetry keep apart package 2 and business turn over material degassing unit 3 airtight connection after being fixed in on the air feeder 1, air feeder 1 divides into two-layer from top to bottom, and the filter that admits air between the upper and lower layer passes through choke valve 110 intercommunication, through the operating condition of each keep apart package 2 of choke valve 110 switching control. Through double-deck symmetrical formula design, with four keep apart package 2 integrated to one set of air supply system each other independently, can effectively subtract and improve space utilization efficiency, be convenient for simultaneously keep apart package 2 to each and concentrate unified management, reduce administrative cost.

The above description is only a preferred embodiment of the present invention, and all equivalent changes or modifications of the structure, characteristics and principles described in the present patent application are included in the protection scope of the present patent application.

Claims

1. The utility model provides an aseptic isolator is used to experimental animals which characterized in that: comprises an isolation bag (2) used for isolating the external environment, an air supply device (1) used for providing clean air for the isolation bag (2) and a feeding and discharging disinfection device (3) used for automatically disinfecting materials entering and exiting the isolation bag (2);

The feeding and discharging disinfection device comprises a first shell (31) and a second shell (37) which are used for forming a cylindrical closed space; the first shell (31) and the second shell (37) are internally and rotatably provided with a sealing material moving device (32) for conveying materials; the sealing material moving device (32) comprises a carrier body (323) for loading materials, a rotor (321) for transporting the materials, a disinfectant nozzle (324) for spraying disinfectant to the surface of the materials and a liquid distributing pipe (329) for controlling the opening and closing time of the disinfectant nozzle (324); the rotor (321) is of a rotary body structure, and a plurality of partition plates (321b) used for forming a sealed space with the first shell (31) and the second shell (37) are axially arranged;

connecting arms (326) with the length of A are symmetrically and fixedly arranged on two sides of the carrier body (323); the axis of the connecting arm (326) is parallel to the bottom surface of the carrier body (323); the other end of the connecting arm (326) is also rotatably provided with a roller (327) for guiding the carrier body (323); a first guide groove (31b) for guiding the roller (327) is formed in the inner side of the bottom surfaces of the first shell (31) and the second shell (37); the first guide groove (31b) is circular and has a radius r; the connection line of the circle center of the first guide groove (31b) and the circle center of the first shell (31) is kept horizontal; the circle center of the first guide groove (31B) deviates to the feeding side by a distance B; the pivoting radius of the hinge point of the carrier body (323) is R; the annular guide groove needs to satisfy the following relationship: b = A, R = R, in order to guarantee the carrier body (323) puts the object plane to be in the horizontality in the arbitrary position.

2. The sterile isolator for laboratory animals according to claim 1, wherein: a first groove (322b) used for being connected with a partition plate (321b) on the rotor (321) is formed in the inner side of the C-shaped surface of the sealing strip (322); a second guide groove (322a) is formed in the contact surface of the sealing strip (322) and the bottom surfaces of the first shell (31) and the second shell (37); the sliding block (3211) is slidably inserted into the second guide groove (322 a); a second hinge hole (3211a) is formed in the middle of the sliding block (3211), and a second hinge shaft (328a) used for being matched with the second hinge hole (3211a) is formed in the end face of one side of the sliding sealing block (328); the sliding sealing block (328) is embedded in the first guide groove (31b) in a sliding manner and is connected with the first guide groove (31b) in an airtight manner.

3. The sterile isolator for laboratory animals according to claim 1, wherein: a liquid pipe fixing seat (33) is fixedly arranged on the outer side of the bottom surface of the first shell (31); the liquid distribution pipe (329) is fixedly arranged on the end surface of the bottom of the liquid pipe fixing seat (33); the liquid separating pipe (329) is inserted into the second mounting hole (321d) and sealed with the inner wall of the second mounting hole (321 d); the liquid separating pipe (329) is of a hollow tubular structure, and a liquid separating groove (329b) for discharging disinfectant is formed in the cylindrical surface; the liquid dividing groove (329b) is vertically downward, and the liquid discharge width is less than 45 degrees.

4. The sterile isolator for laboratory animals according to claim 1, wherein: the number of the carriers is 2, the matched disinfection nozzles are 2 groups and are symmetrically distributed on the rotor (321).

5. The sterile isolator for laboratory animals according to claim 1, wherein: the air supply device (1) comprises a first air inlet filter (11), a second air inlet filter (12), a throttle valve (110), a frame (13), a first exhaust filter (14), a second exhaust filter (17), a primary filter (15), a fan (16), a top plate (19) and a bottom plate (18); the bottom plate (18) is fixedly connected to the frame (13), and the primary filter (15) is fixedly connected to the bottom surface of the bottom plate (18); the fan (16) is fixedly connected to the primary filter (15), and an air outlet of the fan is communicated with an air inlet of the primary filter (15); the first air inlet filter (11) and the first exhaust filter (14) are fixedly connected to the upper surface of the bottom plate (18), and the second air inlet filter (12) and the second exhaust filter (17) are fixedly connected to the top plate (19); the air inlet of the first air inlet filter (11) is communicated with the air outlet of the primary filter (15), the air inlet of the second air inlet filter (12) is communicated with the air outlet of the first air inlet filter through the throttle valve (110).

6. The sterile isolator for laboratory animals according to claim 1, wherein: the isolation bag (2) comprises a bag body (21), long-sleeved gloves (22) and a temperature and humidity sensor (23); the long-sleeve gloves (22) are fixedly and airtightly connected to the front surface of the bag body (21), and the temperature and humidity sensor (23) is fixedly and airtightly connected to the lower position of the middle part of the back surface of the bag body (21); the middle part of the back surface of the bag body (21) is also provided with a connecting window (21c) which is used for being in airtight connection with the feeding and discharging disinfection device (3), and the left side of the connecting window (21c) is provided with an exhaust hole (21a) which is used for being connected with a first exhaust filter (14); and an air inlet hole (21b) used for connecting the first air inlet filter (11) is formed in the right side of the connecting window (21 c).

7. The sterile isolator for laboratory animals according to claim 5, wherein: the isolation bag (2), the feeding and discharging disinfection device (3) and the air supply device (1) are of a bilateral symmetry distribution structure, two sets of isolation bags (2) and the feeding and discharging disinfection device (3) are symmetrically arranged on the bottom plate (18) and the top plate (19), and the air supply opening and closing states are controlled by the throttle valve (110) between the upper layer and the lower layer.