CN113194807B - Sampling device and alimentary canal sampling capsule - Google Patents

Abstract

A sampling device (1) and an alimentary canal sampling capsule, comprising: a housing (11, 11 a); sampling modules (122 a, 12 b) arranged in the casing (11, 1 la); for taking a target sample outside the body (11, 1 a); and an actuating module (13, 13a, 13 b) arranged in the casing (11, 1 a) and used for driving the sampling module (12, 12a, 12 b) to extend or retract the casing (11, 11 a). This sampling device (1) and alimentary canal sampling capsule are stretched out in vivo with brushing target sample through drive sampling module (12, 12a, 12 b)/brush hair portion (121, 121 a), and the target sample of brushing is saved in sampling device (1), has not only avoided traditional disease to be screened, the sample is applyed the misery on the user on one's body when collecting, and the cell quantity of collecting compares and collects more meeting the demand in vitro, convenient and easy to carry out.

Description

Sampling device and alimentary canal sampling capsule

Technical Field

The invention relates to a sampling device, in particular to an in-vivo sampling device and an alimentary canal sampling capsule.

Background

The traditional digestive tract cancer early screening uses an endoscope, the endoscope such as a gastroscope, a enteroscope and the like is sent into a human body from outside through a natural cavity of the human body, and the internal diseases are checked, so that the pathological changes of the internal cavities of organs can be directly observed, the positions and the ranges of the pathological changes can be determined, and the imaging, the biopsy or the brushing can be performed. However, gastroscopy and enteroscopy are poor in comfort, and users often do not accept the gastroscopy and enteroscopy until other symptoms are found in the later stage, and the cancer is usually in the middle and late stages. In addition, the resolution of the gastroscope is limited and can only be found when the tumor tissue is larger than 5 mm.

Studies have shown that there are large differences in the DNA of cancer cells and normal cells at certain targets. Thus, DNA sequencing of a target sample is currently the more efficient way to screen for early cancers.

However, in screening, diagnosing, or otherwise identifying early cancers or other diseases, or in other specific situations, such as cell, gene studies, etc., a number of target samples are obtained, and the most effective way to obtain a number of target samples is in vivo. Therefore, it is necessary to provide a sampling device which is not harmful to living bodies and which is easy and convenient to implement.

Disclosure of Invention

In order to solve the above and other potential problems of the prior art, it is necessary to provide a sampling device and a digestive tract sampling capsule.

In one aspect, there is provided a sampling device comprising: a housing; the sampling module is arranged in the shell and used for extending out of the shell to obtain a target sample; and the actuating module is arranged in the shell and used for driving the sampling module to extend or retract out of the shell.

Further, a protective solution or buffer solution is stored in the shell, and the target sample obtained by the sampling module is stored in the protective solution or buffer solution.

Further, a hole part is formed in the shell, and the sampling module extends out of the shell through the hole part to obtain a target sample.

Further, the whole or partial area of the shell comprises at least one layer of hydrophobic porous material layer, the hydrophobic porous material layer is used for isolating the protective liquid or the buffer liquid from the external liquid, or the whole or partial area of the shell comprises at least one layer of hydrophobic porous film, and the hydrophobic porous film is used for isolating the protective liquid or the buffer liquid from the external liquid.

Further, a one-way valve is arranged at the position where the hole part is located to cover the hole part, the one-way valve is pushed away or partially away from the hole part by the sampling module so as to allow the sampling module to extend out of the shell, and after the sampling module is retracted into the shell, the one-way valve covers the hole part again.

Further, the whole or partial area of the shell also comprises at least one self-sealing material layer, and the sampling module penetrates through the hole part formed on the self-sealing material layer of the shell and is automatically closed after the sampling module is retracted into the shell.

Further, the whole or partial area of the shell is also provided with a dissolvable material layer, and the dissolvable material layer is dissolved after entering the human body.

Further, the sampling module comprises a bristle part and an attaching piece to which the bristle part is attached, and the actuating module drives the attaching piece to swing up and down and/or left and right, rotate or move back and forth so as to expose or retract the bristles of the bristle part from the shell; alternatively, the actuation module drives the attachment to increase or decrease in volume such that bristles of the bristle section are exposed from the housing when the attachment increases in volume and retract into the housing when the attachment decreases in volume.

Further, the actuating module comprises an actuating unit, a control unit for controlling the actuating unit and an energy unit for providing energy for the whole actuating module, wherein the actuating unit is electrically connected with the sampling module and drives the sampling module to extend or retract from the shell under the control of the control unit.

Further, the actuation module further comprises a wireless communication unit for establishing communication connection with an external controller, and the control unit receives an instruction of the external controller through the wireless communication unit to start or stop the actuation unit.

Further, the sampling device further comprises a positioning unit, and the positioning unit is used for providing positioning information for the external controller through the wireless communication unit so that the external controller can acquire the position of the sampling device.

Further, at least two chambers are arranged in the sampling device, the two chambers are sealed and separated, the actuating module is arranged in one chamber, and the sampling module is arranged in the other chamber.

Further, the hole part is arranged on the shell corresponding to the chamber where the sampling module is arranged.

Further, the sampling device is an in-vivo sampling device, or the sampling device is an alimentary canal sampling device, or the sampling device is in a capsule shape.

In another aspect, an alimentary tract sampling capsule is provided that includes an actuation module and a bristle portion driven by the actuation module to extend and retract the sampling capsule to brush a target sample and store the target sample inside the sampling capsule.

Further, a protective liquid or buffer liquid is stored in the sampling capsule, and the brushed target sample is stored in the protective liquid or buffer liquid.

Further, a device or a material for isolating the protective liquid or the buffer liquid from the external liquid is arranged on the sampling capsule.

Further, a hole is formed in the sampling capsule, the bristle part extends out of and retracts into the sampling capsule through the hole, the device or material for isolating the protective liquid or the buffer liquid from the external liquid is a one-way valve for covering the hole, the one-way valve is pushed away or partially away from the hole by the bristle part so as to allow the bristle part to extend out of the sampling capsule, and after the bristle part retracts into the sampling capsule, the one-way valve covers the hole again.

Further, the device or material for isolating the protection liquid or buffer liquid from the external liquid is a self-sealing material layer, the self-sealing material layer is used for the penetration of the bristle part, and after the bristle part is retracted into the sampling capsule, the hole part formed by the penetration of the bristle part is automatically closed so as to isolate the protection liquid or buffer liquid from the external liquid.

Further, the device or material for isolating the protective liquid or buffer liquid from the external liquid is a hydrophobic porous material layer or a hydrophobic porous film.

Further, the sampling capsule is coated with a layer of dissolvable material, which is dissolved after entering the human body.

According to the sampling device and the alimentary canal sampling capsule provided by the embodiment of the invention, the sampling module and the brush hair part are driven to extend out of the body to brush the target sample, and the brushed target sample is stored in the sampling device, so that the pain of a user during traditional disease screening and specimen collection is avoided, the number of the collected cells can meet the requirement more than in-vitro collection, and the sampling device is convenient and easy to implement.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are needed in the embodiments of the present invention will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic diagram of a sampling device according to an embodiment of the present invention.

Fig. 2 is a schematic view of a micro check valve provided with a hole portion of the sampling device shown in fig. 1.

Fig. 3 is a schematic view of an actuator module of the sampling device of fig. 1.

Fig. 4 is a schematic view of another component of the actuation module of the sampling device of fig. 1.

Fig. 5 is a schematic view of the sampling device of fig. 1 with bristles received in a housing.

Fig. 6 is a schematic view of the sampling device of fig. 1 with bristles extending out of the housing.

Fig. 7A and 7B are partial schematic views of a sampling device according to a second embodiment of the present invention, wherein fig. 7A is a case where bristles are located in a housing, and fig. 7B is a case where bristles protrude out of the housing.

Fig. 8A and 8B are partial schematic views of a sampling device according to a third embodiment of the present invention, in which fig. 8A is a case where bristles are located in a housing, and fig. 8B is a case where bristles protrude out of the housing.

Fig. 9A and 9B are partial schematic views of a sampling device according to a fourth embodiment of the present invention, in which fig. 9A is a case where bristles are located in a housing, and fig. 9B is a case where bristles protrude out of the housing.

DESCRIPTION OF SYMBOLS IN THE DRAWINGS

The invention will be further described in the following detailed description in conjunction with the above-described figures.

Detailed Description

The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

It is noted that when an element is referred to as being "fixed" to "or" mounted on "another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "disposed on" another element, it can be directly on the other element or intervening elements may also be present. The term "and/or" as used herein includes all and any combination of one or more of the associated listed items.

Fig. 1 is a schematic diagram of a sampling device according to an embodiment of the invention. The sampling device 1 comprises a housing 11, a sampling module 12 arranged in the housing, and an actuating module 13 for driving the sampling module 12 to sample. In this embodiment, the sampling device is a digestive tract sampling capsule, the housing 11 is in the shape of a capsule, and the interior of the housing 11 is divided into two sealed chambers: a first chamber 111 and a second chamber 112. The first chamber 111 is adapted to house the sampling module 12 and the second chamber 112 is adapted to house the actuation module 13. A partition 113 is arranged between the first chamber 111 and the second chamber 112, and the sampling module 12 is connected to the actuation module 13 through the partition 113, so that the actuation module 13 actuates the sampling module 12.

It will be appreciated that in another embodiment, the actuation module 13 is connected to the sampling module 12 through the partition 113 in order to actuate the sampling module 12.

The sampling module 12 includes a bristle part 121 and an attachment member 122 to which the bristle part 121 is attached, the attachment member 122 is substantially rod-shaped, the bristle part 121 is formed on an outer surface of the attachment member 122, and bristles of the bristle part 121 extend from the outer surface of the attachment member 122 toward the housing 11. In this embodiment, the housing 11 is provided with a plurality of holes 114, and the holes 114 are distributed on the housing 11 regularly or irregularly corresponding to the positions of the bristle parts 121. The aperture 114 allows the bristles to extend or retract into the housing 11. The bristles extend out of the housing 11 through the hole 114 to brush target samples, such as tissue cells, and after being retracted into the housing 11, the brushed target samples are stored in the first chamber 111, and further, a protecting liquid or buffer 115 is stored in the first chamber 111 to maintain the activity of the target samples, prevent the target samples from being damaged, and/or clean the target samples.

It should be understood that the housing 11 may not be divided into two or more chambers, or the actuation module 13 and the sampling module 12 may be disposed in the same chamber, and the actuation module 13 may be sealed by the protection liquid or buffer 115 in the same chamber.

In this embodiment, the outermost layer of the housing 11 is a hydrophobic porous material layer 116 to isolate the protecting liquid or buffer liquid 115 inside the housing 11 from external liquid, such as isolating the protecting liquid or buffer liquid 115 from digestive liquid in the digestive tract. The hydrophobic material used for the hydrophobic porous material layer 116 may be a material having hydrophobicity itself, or may be a material obtained by subjecting other materials to hydrophobic treatment. Preferably, the hydrophobic porous material layer 116 may be a hydrophobic film or coating, such as a polytetrafluoroethylene film or coating.

It is understood that the hydrophobic porous material layer 116 need not be disposed at all positions of the housing 11, and only the porous material layer 116 need be disposed at the positions of the holes 114. The hydrophobic porous material layer 116 is not necessarily disposed on the outermost layer of the casing 11, but may be disposed on the innermost layer of the casing 11 or one of the intermediate layers of the casing 11. Alternatively, two or more hydrophobic porous material layers 116 may be provided to further enhance the barrier effect.

It will be appreciated that in other embodiments, the entire or partial region of the housing 11 may be formed from a hydrophobic porous material from inside to outside, i.e., the hydrophobic porous material forms the only material layer of the entire or partial region of the housing 11 from inside to outside. In the case where the case 11 is formed of a hydrophobic porous material in a partial region from inside to outside, for example, only the case portion corresponding to the first chamber 111 is formed of a hydrophobic porous material from inside to outside in its entirety, and the case portion corresponding to the second chamber 112 is formed of other materials; alternatively, the porous material may be formed of a hydrophobic material from inside to outside only in a plurality of partial areas of the housing portion corresponding to the first chamber 111.

In summary, in at least one embodiment of the present invention, the housing 11 includes at least one layer of hydrophobic material, which may form one of the layers of the housing 11, or may be the only layer of material of the housing 11 from inside to outside.

It will be appreciated that in other embodiments, the housing 11 is made in whole or in part of a self-sealing material, which may be applied to a localized area of the housing 11 or constitute one of the layers of the housing 11, or which constitutes one of the localized areas of the housing 11, in the case where a self-sealing material is employed for part of the housing 11. The self-sealing material includes, but is not limited to, silica gel, gel-type materials such as agarose, and the like. The bristles can brush a target sample through the housing 11, and after the bristles retract into the housing 11, the hole 114 of the housing 11 through which the bristles pass automatically contracts and closes, thereby ensuring that no liquid is exchanged between the inside and the outside of the housing 11.

When the whole or partial area of the housing 11 is made of a self-sealing material, the bristles can penetrate through the housing 11, so that the housing 11 does not need to be provided with the hole 114 in advance. The hole 114 is formed only after the penetration of the bristle. When the self-sealing material is only one layer of the whole or partial area of the housing 11 from inside to outside, and other layers of the housing 11 from inside to outside are not self-sealing materials, the other layers may be provided with holes 114 correspondingly.

It will be appreciated that in other embodiments, in the case that neither the hydrophobic porous material nor the self-sealing material is provided, as shown in fig. 2, a micro check valve 117 may be provided at the position of the hole 114 to isolate the liquid on the inner side and the outer side of the housing 11, where the micro check valve 117 is provided with an elastic structure, and when not receiving the bristle pushing force, the micro check valve 117 covers the hole 114 to isolate the liquid on the inner side and the outer side of the housing 11. The elastic structure deforms when subjected to bristle pushing force, causing the micro check valve 117 to move away or partially move away from the aperture 114 to allow bristles to extend from the aperture 114, and the elastic structure of the micro check valve 117 deforms back when the bristles retract into the housing 11, the micro check valve 117 re-covering the aperture 114.

It will be appreciated that in other embodiments, at least a partial region of the housing 11 may also be provided with a dissolvable material that dissolves under the action of body fluid after entering the body, thereby exposing an underlying layer (e.g., a layer of hydrophobic porous material, self-sealing material, or other material), or forming the aperture 114 as described above.

It will be appreciated that in other embodiments, two or more of the above approaches may be employed simultaneously to isolate the fluid from the interior and exterior of the housing 11. For example, a hydrophobic porous material layer may be provided on the case 11, a self-sealing material may be provided, and the hydrophobic porous material layer and the self-sealing material may be stacked on each other.

The actuating module 13 includes an actuating unit 131, a control unit 132 and an energy unit 133, wherein the actuating unit 131 may be a motor, such as a micro motor, or a motor integrated with a transmission member driven by the motor. The control unit 132 may be a micro control chip and the energy unit 133 may be a battery, such as a micro battery. The actuating unit 131, the control unit 132 and the energy unit 133 are integrated on a circuit board 134, and are electrically connected to each other through the circuit board 134. For example, the energy unit 133 supplies power to the actuating unit 131 and the control unit 132 through the circuit board 134, and the control unit 132 controls the control of the power supply of the actuating unit 131 by the energy unit 133 through the circuit board 134, such as turning on or off the power supply of the actuating unit 131, thereby starting or stopping the actuating unit 131. Of course, other components may be provided on the circuit board 134 as desired.

The control unit 132 runs a control program, and in this embodiment, the control unit 132 runs the control program to control the actuation unit 131 to be intermittently activated, for example, after the user swallows the sampling device 1, the control unit 132 activates the actuation unit 131 at intervals of, for example, one hour, and controls the actuation unit 131 to operate for a duration of, for example, 5 minutes. Of course, the actuation module 13 may further include a sensing unit (not shown), for example, a temperature sensing unit, which senses whether the sampling device 1 is swallowed by the user by using the temperature difference between the inside and the outside of the body, for example, a ph detecting unit, which determines whether the sampling device 1 has reached a specific location, such as the stomach, by using the detected ph value.

Referring to fig. 3, the actuation module 13a in another embodiment further includes a wireless communication unit 135, where the wireless communication unit 135 is disposed on the circuit board 134 and communicates with an external controller 2 through bluetooth, WIFI, etc. For example, the wireless communication unit 135 may receive an instruction sent by the external controller 2, transmit the instruction to the control unit 132, and parse and execute the instruction by the control unit 132. In a specific case, the external controller 2 may send a control instruction of "start" and "stop" to the actuation module 13, the wireless communication unit 135 may send the control instruction to the control unit 132 after receiving the control instruction of "start" sent by the external controller 2, the control unit 132 may start the operation of the actuation unit 131 according to the control instruction, the wireless communication unit 135 may send the control instruction to the control unit 132 after receiving the control instruction of "stop" sent by the external controller 2, and the control unit 132 may stop the operation of the actuation unit 131 according to the control instruction. In another specific case, the external controller 2 may also transmit other control parameters to the actuation module 13, such as a parameter indicating how long to activate the actuation unit 131 every time, and/or a parameter indicating how long to last each activation of the actuation unit 131, etc.

Referring to fig. 4, the actuating module 13b in an embodiment further includes a positioning unit 136, where the positioning unit 136 is configured to obtain positioning information of the sampling device 1, send the positioning information to the external controller 2 via the wireless communication unit 135, and the external controller 2 analyzes the positioning information of the sampling device 1 and obtains position information of the sampling device 1. Further, the external controller 2 may generate corresponding control instructions and/or control parameters according to the position information of the sampling device 1. For example, the external controller 2 activates the operation unit 131 through the control unit 132 only when the sampling device 1 is located at a site where a target sample is to be brushed, such as the stomach, and the external controller 2 stops the operation of the operation unit 131 through the control unit when the sampling device 1 is located at other sites. For another example, when the sampling device 1 is located in some important part, such as the stomach, the external controller 2 may send corresponding control parameters to the control unit 132, so that the control unit 132 controls the actuation unit 131 to be activated more frequently or to operate more permanently each time. While in a non-critical location, such as the intestinal tract, the external controller 2 may cause the control unit 132 to control the actuation unit 131 to reduce the number of activations or reduce the duration of each operation.

The positioning unit 136 may obtain positioning information of the sampling device 1 using a magnetic field, for example using a magnetic target real-time positioning tracking system based on a three-axis magnetic sensor array. Alternatively, the positioning unit 136 may also use an optical sensor such as a camera to transmit the image of the surrounding environment of the sampling device 1 to generate the positioning information of the sampling device 1, and the positioning unit 136 may also use a radio frequency positioning technology to obtain the positioning information of the sampling device 1.

Referring to fig. 1, 5 and 6, in the present embodiment, the housing 11 is in a capsule shape, and a plurality of holes 114 are disposed at positions of the housing 11 corresponding to the bristles, and the holes 114 may be arranged according to a certain rule or may be arranged irregularly. The diameter of the hole part is approximately 10um-3mm, and the diameter size of the bristle is 5um-1mm. Depending on the location of the attachment 122 on the central axis of the housing 11, the bristles extend from the periphery of the attachment 122 toward the housing 11, and the length of the bristles is greater than the dimension of the attachment 122 to the housing 11, and further, the length of the bristles is preferably such that the bristles can extend from the aperture 114. Upon rotation of the attachment 122 by actuation of the actuation module 13, the bristles follow the rotation of the attachment 122, and when the bristle tips reach the location of the aperture 114, they extend from the aperture 114 to brush the target sample. After the attachment 122 brings the bristles away from the location of the aperture 114, the bristle tips are forced to retract into the housing 11.

It will be appreciated that the bristles need not be disposed about the periphery of the attachment 122, and in other embodiments, the bristles may be disposed only in a partial region about the periphery of the attachment 122. The hole 114 is not necessarily disposed in all areas of the housing 11 corresponding to the first chamber 111, and the hole 114 may be disposed only in a small area. In summary, the distribution area, the size of the distribution area and the distribution rule of the bristles and the hole 114 can be set according to specific needs, and only the bristles can extend out of the hole 114 to brush a target sample under the actuation of the actuation module 13, and then retract into the housing 11 under the actuation of the actuation module 13.

It will be appreciated that the diameter of the bristles and the aperture 114 is not limited to the above-mentioned values, and that the diameter of the bristles and the aperture 114 may be modified according to actual needs, and that the bristles can only extend from the aperture 114 when the actuation module 13 is actuated. In addition, the hole portion 114 is not necessarily a circular hole, and may be an elongated hole or a hole of another shape. For example, in one embodiment, the aperture 114 may be an elongated aperture extending in the direction of bristle rotation.

Referring to fig. 7A and 7B, in the embodiment shown in fig. 7A and 7B, the attachment member 122 drives the bristles to swing in at least one direction under the actuation of the actuation module 13, for example, by taking the central axis of the housing 11 as a reference, setting the extending direction of the central axis of the housing 11 as the front-back direction, and setting the periphery of the central axis of the housing 11 as the up-down and left-right directions, where the attachment member 122 can drive the bristles to swing only up, only down, only left, only right, or drive the bristles to swing up-down, left-right, or up-down and left-right in a certain order under the actuation of the actuation module 13, so that the bristles extend from the holes 114 in the corresponding direction.

When the attachment 122 drives the brush to swing in only one direction or drives the brush to swing in two directions, but the two directions are not opposite directions, the attachment 122 does not need to be arranged along the central axis of the housing 11.

Referring to fig. 8A and 8B, in the embodiment shown in fig. 8A and 8B, the housing 11a is generally tapered corresponding to the end of the sampling module 12a, the lengths of the bristles of the bristle part 121a also gradually decrease, the actuating module 13 is actuated to move back and forth according to the attachment 122, and during the moving process, the longer bristles extend from the hole 114 at the smaller diameter of the housing 11a to brush the target sample, and then retract into the housing 11 a.

Referring to fig. 9A and 9B, in the embodiment shown in fig. 9A and 9B, the sampling module 12B includes a bristle part 121 and a supporting part 122a, the supporting part 122a is made of a stretchable material, the actuating module 13 drives the supporting part 122a to increase or decrease in volume, for example, the actuating module 13 may include a gas source (not shown) for increasing or decreasing the volume of the supporting part 122a by adding or subtracting gas to the interior of the supporting part 122a, driving the bristles to extend from the hole 114 when the volume of the supporting part 122a increases, and driving the bristles to retract into the housing 11 when the volume of the supporting part 122a decreases.

It will be appreciated that the attachment member 122a may be made of a different material than elastic material, and the size and volume of the attachment member 122a may be changed by structural design, so as to change the distance between the bristles and the corresponding holes 114.

The present invention will be further described below with reference to a case where the sampling device 1 is applied to sampling cells in the digestive tract.

After the user swallows the sampling device 1, the sampling device 1 automatically starts the control unit 132 to run the control program according to the sensed temperature change or other parameters, or the sampling device 1 starts the control unit 132 to run the control program to intermittently start-stop the operation unit 131 according to the control instruction transmitted from the external controller 2. The actuating unit 131 actuates the sampling module 12 to enable the bristles of the sampling module 12 to extend out of the shell 11 (or 11 a) to brush the target sample, the actuating unit 131 then drives the sampling module 12 to enable the bristles to retract into the shell 11 (or 11 a), the target sample obtained by brushing is stored in the shell 11 (or 11 a), and the protection liquid or buffer 115 in the shell 11 (or 11 a) maintains the activity of the target sample or prevents the target sample from being damaged. Finally, the sampling device 1 is discharged from the body along with the feces, the sampling device 1 is recovered, and DNA sequencing can be carried out on a target sample in the sampling device 1 to realize screening and detection of diseases such as early cancers, collection of specimens for other purposes and the like.

According to the sampling device and the alimentary canal sampling capsule provided by the embodiment of the invention, the sampling module is driven to extend out of the body to brush the target sample, and the brushed target sample is stored in the sampling device, so that the pain of a user during traditional disease screening and sample collection is avoided, the number of collected cells can meet the requirement more than in-vitro collection, and the sampling device and the alimentary canal sampling capsule are convenient and easy to implement.

Finally, it should be noted that the above-mentioned embodiments are merely for illustrating the technical solution of the present invention and not for limiting the same, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications and equivalents may be made to the technical solution of the present invention without departing from the spirit and scope of the technical solution of the present invention.

Claims (18)

1. A sampling device, comprising:

a housing;

the sampling module is arranged in the shell and used for extending out of the shell to obtain a target sample; a kind of electronic device with high-pressure air-conditioning system

The actuating module is arranged in the shell and used for driving the sampling module to extend or retract into the shell, the actuating module comprises an actuating unit, a control unit for controlling the actuating unit and an energy unit for providing energy for the whole actuating module, the actuating unit is electrically connected with the sampling module and used for driving the sampling module to extend or retract into the shell under the control of the control unit,

and the protecting liquid or the buffer liquid is stored in the shell, and the target sample acquired by the sampling module is stored in the protecting liquid or the buffer liquid.

2. The sampling device of claim 1, wherein the housing defines an aperture, and the sampling module extends out of the housing through the aperture to obtain a target sample.

3. The sampling device of claim 2, wherein the housing comprises at least one layer of hydrophobic porous material in the region of the housing that isolates the protective or buffer solution from the external liquid, or at least one layer of hydrophobic porous membrane in the region of the housing that isolates the protective or buffer solution from the external liquid.

4. A sampling device according to claim 2 or claim 3, wherein the aperture is provided with a one-way valve covering the aperture, the one-way valve being pushed by the sampling module out of or partially out of the aperture to allow the sampling module to extend out of the housing, the one-way valve re-covering the aperture after the sampling module has been retracted into the housing.

5. A sampling device according to claim 1 or claim 2, wherein the housing in whole or in part further comprises at least one layer of self-sealing material, the sampling module automatically closing through an aperture formed in the housing in the layer of self-sealing material after the sampling module is retracted into the housing.

6. The sampling device of claim 1, wherein the housing is further provided in whole or in part with a layer of dissolvable material that dissolves upon entry into the human body.

7. The sampling device of claim 1, wherein the sampling module comprises a bristle portion and an attachment to which the bristle portion is attached, the actuation module driving the attachment to swing up and down and/or side-to-side, rotate or move back and forth to expose or retract bristles of the bristle portion from or into the housing; alternatively, the actuation module drives the attachment to increase or decrease in volume such that bristles of the bristle section are exposed from the housing when the attachment increases in volume and retract into the housing when the attachment decreases in volume.

8. The sampling device of claim 1, wherein the actuation module further comprises a wireless communication unit for establishing a communication connection with an external controller, the control unit receiving instructions from the external controller via the wireless communication unit to activate or deactivate the actuation unit.

9. The sampling device of claim 8, further comprising a positioning unit for providing positioning information to the external controller via the wireless communication unit for the external controller to obtain the location of the sampling device.

10. The sampling device of claim 1, wherein at least two chambers are disposed within the sampling device, the two chambers being hermetically separated, the actuation module being disposed within one of the chambers and the sampling module being disposed within the other chamber.

11. The sampling device of claim 2, wherein at least two chambers are provided in the sampling device, the two chambers are sealed and separated, the actuation module is disposed in one chamber, the sampling module is disposed in the other chamber, and the hole is opened on the housing corresponding to the chamber in which the sampling module is disposed.

12. The sampling device of claim 1, wherein the sampling device is an in vivo sampling device, or wherein the sampling device is an alimentary canal sampling device, or wherein the sampling device is in the shape of a capsule.

13. An alimentary canal sampling capsule, characterized in that it comprises an actuation module and a bristle part driven by the actuation module to extend and retract the sampling capsule, so as to brush a target sample and store the target sample inside the sampling capsule; the actuating module comprises an actuating unit, a control unit for controlling the actuating unit and an energy unit for providing energy for the whole actuating module, wherein the actuating unit is electrically connected with the bristle part and drives the bristle part to extend or retract the sampling capsule under the control of the control unit; and the sampling capsule stores a protective solution or a buffer solution, and the brushed target sample is stored in the protective solution or the buffer solution.

14. The sampling capsule of claim 13, wherein means or material is provided on the sampling capsule to isolate the protective or buffer fluid from external fluids.

15. The sampling capsule of claim 14, wherein the sampling capsule is provided with an aperture through which the bristle portion extends and retracts into the sampling capsule, the means or material for isolating the protective or buffer liquid from the ambient liquid being a one-way valve covering the aperture, the one-way valve being pushed by the bristle portion out of or partially out of the aperture to allow the bristle portion to extend out of the sampling capsule, the one-way valve re-covering the aperture after the bristle portion retracts into the sampling capsule.

16. The sampling capsule of claim 14, wherein the means or material for isolating the protective or buffer fluid from the external fluid is a layer of self-sealing material through which the bristle portion pierces and wherein the aperture formed by the bristle portion piercing is automatically closed to isolate the protective or buffer fluid from the external fluid after the bristle portion is retracted within the sampling capsule.

17. The sampling capsule of claim 14, wherein the means or material for isolating the protective or buffer fluid from the external fluid is a layer of hydrophobic porous material or a hydrophobic porous membrane.

18. The sampling capsule of claim 13, wherein the sampling capsule is surrounded by a layer of dissolvable material that is dissolved upon entry into the human body.