WO2020102997A1

WO2020102997A1 - Sampling device and digestive tract sampling capsule

Info

Publication number: WO2020102997A1
Application number: PCT/CN2018/116524
Authority: WO
Inventors: 魏婕; 秦彦哲
Original assignee: 深圳华大智造科技有限公司
Priority date: 2018-11-20
Filing date: 2018-11-20
Publication date: 2020-05-28
Also published as: CN113194807B; CN113194807A

Abstract

A sampling device (1) and a digestive tract sampling capsule. Said device comprises a housing (11, 11a); a sampling module (12, 12a, 12b) arranged in the housing (11, 11a) and used for extending out of the housing (11, 11a) to acquire a target sample; and an actuation module (13, 13a, 13b) arranged in the housing (11, 11a) and used for driving the sampling module (12, 12a, 12b) to extend out of or retract into the housing (11, 11a). The sampling device (1) and the digestive tract sampling capsule brush the target sample by driving the sampling module (12, 12a, 12b)/a brush portion (121, 121a) to extend out of a body, and the brushed target sample is stored in the sampling device (1), so that pain imposed on a user during traditional disease screening and specimen collection is avoided, and the number of collected cells can meet the requirements better than in vitro collection. The present invention is convenient and easy to implement.

Description

Sampling device and digestive tract sampling capsule

Technical field

The invention relates to a sampling device, in particular to a body sampling device and a digestive tract sampling capsule.

Background technique

Traditional gastrointestinal cancer early screening uses an endoscope. Endoscopes, such as gastroscopes and enteroscopy, are sent from the outside of the body through the natural cavity of the human body into the body to check the disease in the body. , Range, and can be photographed, biopsy or brush. However, the comfort of gastroscopes and enteroscopy is not good, and the user acceptance is not high. It is often only when the other symptoms are found in the later stage that they are willing to undergo the examination. At this time, it is generally in the middle and advanced stages of cancer. In addition, the resolution of gastrointestinal endoscopy is limited, and can only be found when the tumor tissue is larger than 5 mm.

Studies have shown that the DNA of cancer cells and normal cells have huge differences in certain targets. Therefore, DNA sequencing of the target sample is currently a more effective way of early cancer screening.

Of course, whether it is screening or diagnosis of early cancer or other diseases, or in other specific circumstances, such as the study of cells and genes, a certain number of target samples are required, and obtaining a certain number of target samples is most effective The way is to obtain in vivo. Therefore, it is necessary to provide a sampling device that does not cause damage to living bodies and is convenient and easy to implement.

Summary of the invention

In order to solve the above-mentioned and other potential problems in the prior art, it is necessary to propose a sampling device and a digestive tract sampling capsule.

In one aspect, a sampling device is provided, including: a housing; a sampling module, placed in the housing, for extending out of the housing to obtain a target sample; and an actuation module, placed in the housing, for The sampling module is driven to extend or retract the housing.

Further, a protective solution or a buffer solution is stored in the housing, and the target sample obtained by the sampling module is stored in the protective solution or the buffer solution.

Further, a hole portion is formed in the housing, and the sampling module extends out of the housing through the hole portion to obtain a target sample.

Further, the whole or partial area of the casing includes at least one layer of hydrophobic porous material, and the layer of hydrophobic porous material is used to isolate the protective liquid or the buffer liquid from the external liquid, or the whole or part of the casing The local area includes at least one layer of a hydrophobic porous film, which is used to isolate the protective liquid or the buffer liquid from the external liquid.

Further, a check valve is provided at the location of the hole portion to cover the hole portion, and the check valve is pushed away or partially away from the hole portion by the sampling module to allow the sampling module to extend out of the housing After the sampling module is retracted into the housing, the one-way valve covers the hole again.

Further, the whole or partial area of the housing further includes at least one layer of self-closing material, and the sampling module passes through the hole formed in the self-closing material layer of the housing to retract at the sampling module The housing is automatically closed afterwards.

Further, a dissolvable material layer is further provided in the whole or partial area of the housing, and the dissolvable material layer is dissolved after entering the human body.

Further, the sampling module includes a bristle portion and an attachment attached to the bristle portion, and the actuation module drives the attachment to oscillate, rotate, or move back and forth and / or left and right to make the bristles of the bristle portion Exposing or retracting the housing from the housing; or, the actuation module drives the volume of the attachment to increase or decrease, so that the bristles of the bristle portion from when the volume of the attachment increases The casing is exposed and retracted into the casing when the volume of the attachment is reduced.

Further, the actuation module includes an actuation unit, a control unit that controls the actuation unit, and an energy unit that provides energy to the actuation module as a whole, the actuation unit is electrically connected to the sampling module, and The sampling module is driven to extend or retract the casing under the control of the control unit.

Further, the actuation module further includes a wireless communication unit for establishing a communication connection with an external controller, and the control unit receives an instruction of the external controller through the wireless communication unit to start or stop the operation Motion unit.

Further, the sampling device further includes a positioning unit for providing positioning information to the external controller through the wireless communication unit, so that the external controller can obtain the location of the sampling device.

Further, at least two chambers are provided inside the sampling device, and the two chambers are sealed and separated, the actuating module is provided in one of the chambers, and the sampling module is provided in the other chamber.

Further, the hole portion is opened on the housing corresponding to the chamber where the sampling module is located.

Further, the sampling device is an in vivo sampling device, or the sampling device is a digestive tract sampling device, or the sampling device is in the shape of a capsule.

In another aspect, a digestive tract sampling capsule is provided. The sampling capsule includes an actuation module and a bristle portion that extends and retracts the sampling capsule driven by the actuation module to brush the target sample and the target sample Keep inside the sampling capsule.

Further, a protective solution or buffer solution is stored in the sampling capsule, and the target sample brushed is stored in the protective solution or buffer solution.

Further, the sampling capsule is provided with a device or material that isolates the protection liquid or the buffer liquid from the external liquid.

Further, a hole portion is formed on the sampling capsule, the bristle portion extends and retracts into the sampling capsule through the hole portion, and the device or material that isolates the protection liquid or the buffer liquid from the external liquid is A one-way valve covering the hole portion, the one-way valve is pushed away or partially away from the hole portion by the bristle portion to allow the bristle portion to extend out of the housing and retract at the bristle portion After the housing, the one-way valve covers the hole again.

Further, the device or material that isolates the protection liquid or the buffer liquid from the external liquid is a self-sealing material layer, and the self-sealing material layer allows the bristle portion to pierce through and retracts the bristle portion at the After sampling the capsule, the hole formed by the puncture of the bristle portion is automatically closed to isolate the protection liquid or the buffer liquid from the external liquid.

Further, the device or material that isolates the protection liquid or the buffer liquid from the external liquid is a hydrophobic porous material layer or a hydrophobic porous film.

Further, the sampling capsule is wrapped with a layer of soluble material, and the layer of soluble material is dissolved after entering the human body.

The sampling device and the gastrointestinal sampling capsule provided by the embodiment of the present invention drive the sampling module-the bristle part protrudes in the body to brush the target sample, and the brushed target sample is stored in the sampling device, thus not only avoiding traditional disease Pain applied to the user during the inspection and specimen collection, and the number of collected cells can meet the needs more than in vitro collection, and is convenient and easy to implement.

BRIEF DESCRIPTION

In order to more clearly explain the technical solutions of the embodiments of the present invention, the drawings required in the embodiments of the present invention will be briefly described below. Obviously, the drawings in the following description are only some embodiments of the present invention. Those of ordinary skill in the art can obtain other drawings based on these drawings without creative efforts.

FIG. 1 is a schematic diagram of a sampling device in an embodiment of the present invention.

FIG. 2 is a schematic diagram of a micro check valve provided with a hole of the sampling device shown in FIG. 1.

3 is a schematic diagram of a composition of the actuating module of the sampling device shown in FIG. 1.

4 is a schematic diagram of another composition of the actuating module of the sampling device shown in FIG. 1.

FIG. 5 is a schematic diagram of the sampling device shown in FIG. 1 with the bristles received in the housing.

6 is a schematic diagram of the sampling device shown in FIG. 1 with bristles extending out of the housing.

7A and 7B are partial schematic diagrams of the sampling device in the second embodiment of the present invention, where FIG. 7A is a case where the bristles are located inside the housing, and FIG. 7B is a situation where the bristles extend out of the housing.

8A and 8B are partial schematic diagrams of a sampling device in a third embodiment of the present invention, where FIG. 8A is a case where the bristles are located inside the housing, and FIG. 8B is a situation where the bristles extend out of the housing.

9A and 9B are partial schematic diagrams of the sampling device in the fourth embodiment of the present invention, wherein FIG. 9A is a case where the bristles are located inside the housing, and FIG. 9B is a situation where the bristles extend out of the housing.

The following specific embodiments will further illustrate the present invention with reference to the above drawings.

Component symbol description

detailed description

The technical solutions in the embodiments of the present invention will be described clearly and completely in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, but not all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by a person of ordinary skill in the art without making creative efforts fall within the protection scope of the present invention.

It should be noted that when a component is referred to as "fixed" or "installed" on another component, it can be directly on another component or there can also be a centered component. When a component is considered to be "set on" another component, it may be set directly on another component or there may be a centered component at the same time. The term "and / or" as used herein includes all and any combinations of one or more related listed items.

Please refer to FIG. 1, which is a schematic diagram of a sampling device according to an embodiment of the present invention. The sampling device 1 includes a casing 11, a sampling module 12 disposed in the casing, and an actuating module 13 that drives the sampling module 12 to sample. In this embodiment, the sampling device is a gastrointestinal sampling capsule, the housing 11 is in the shape of a capsule, and the interior of the housing 11 is divided into two sealed chambers: the first chamber 111 and the first二 Chamber 112. The first chamber 111 is used to house the sampling module 12, and the second chamber 112 is used to house the actuation module 13. A partition 113 is provided between the first chamber 111 and the second chamber 112, and the sampling module 12 is connected to the actuation module 13 through the partition 113, so that the actuation module 13 actuates the sampling module 12.

It can be understood that, in another embodiment, the actuation module 13 is connected to the sampling module 12 through the partition 113 to actuate the sampling module 12.

The sampling module 12 includes a bristle portion 121 and an attachment 122 to which the bristle portion 121 is attached. The attachment 122 is substantially rod-shaped. The bristle portion 121 is formed on the outer surface of the attachment 122. The bristles extend from the outer surface of the attachment 122 toward the housing 11. The housing 11 is provided with holes 114. In this embodiment, the number of the holes 114 is multiple. The holes 114 are regularly or irregularly distributed on the housing 11 corresponding to the positions of the bristle parts 121. . The hole 114 allows the bristles to extend or retract into the housing 11. The bristles extend out of the housing 11 through the hole 114 and brush to take a target sample, such as tissue cells. After retracting into the housing 11, the brushed target sample is stored in the first chamber 111. Further, A chamber 111 stores a protective solution or buffer 115 to maintain the activity of the target sample, prevent the target sample from being damaged, and / or clean the target sample.

It can be understood that the interior of the housing 11 may not be divided into two or more chambers, or the actuation module 13 and the sampling module 12 are both placed in the same chamber, in this case, only the actuation module 13 needs to be sealed and isolated from the same chamber Indoor protection liquid or buffer 115 is sufficient.

In this embodiment, the outermost layer of the shell 11 is a layer of hydrophobic porous material 116 to isolate the protective liquid or buffer 115 inside the shell 11 from external liquids, such as isolating the protective liquid or buffer 115 from digestion The digestive juice in the tract. The hydrophobic material used in the hydrophobic porous material layer 116 may be a material that is inherently hydrophobic, or may be a material obtained after other materials undergo hydrophobic treatment. Preferably, the hydrophobic porous material layer 116 may be a hydrophobic film or coating, such as a Teflon film or coating.

It can be understood that not all positions of the housing 11 need to be provided with the hydrophobic porous material layer 116, and only the position of the hole 114 is required to be provided with the hydrophobic porous material layer 116. It is not necessary that the hydrophobic porous material layer 116 is provided on the outermost layer of the casing 11, but may also be provided on the innermost layer of the casing 11 or one of the intermediate layers of the casing 11. Alternatively, to further improve the isolation effect, two or more layers of hydrophobic porous material 116 may also be provided.

It can be understood that, in other embodiments, the entire or partial area of the casing 11 may be composed of a hydrophobic porous material from the inside to the outside, that is, the hydrophobic porous material constitutes the only material from the inside to the outside of the entire or partial area of the casing 11 Floor. In the case where a partial porous area of the housing 11 is composed of a hydrophobic porous material from the inside to the outside, for example, for example, only the entire housing portion corresponding to the first chamber 111 is composed of a hydrophobic porous material from the inside to the outside. The housing portion corresponding to the second chamber 112 is composed of other materials; or, only in a plurality of partial regions of the housing portion corresponding to the first chamber 111, it is composed of a hydrophobic porous material from inside to outside.

In summary, in general, in at least one embodiment of the present invention, the housing 11 includes at least one layer of hydrophobic material, and the hydrophobic material layer may constitute one of the layers of the housing 11 or the housing 11 may be The only material layer from inside to outside.

It can be understood that, in other embodiments, the housing 11 is entirely or partially made of a self-closing material. In the case where the housing 11 uses a self-closing material, the self-closing material may be applied to a partial area of the housing 11 or One layer of the housing 11 is formed, or the self-closing material forms one layer of a partial area of the housing 11. The self-sealing material includes but is not limited to silica gel, gel-like materials such as agarose and the like. The bristles can be brushed through the housing 11 to take a target sample. After the bristles are retracted into the housing 11, the holes 114 on the housing 11 through which the bristles pass automatically shrink and close, thereby ensuring that there is no exchange of liquid inside and outside the housing 11.

When the entire or partial area of the housing 11 is made of only a self-sealing material from the inside to the outside, the bristles can puncture and pass through the housing 11, so the housing 11 does not need to have a hole 114 in advance. The hole 114 is formed only after the bristles are punctured. When the self-closing material is only one layer of the entire or partial area of the housing 11 from the inside to the outside, and there are other layers from the inside to the outside of the housing 11 that are not self-closing materials, holes 114 can be correspondingly formed in these other layers .

It can be understood that in other embodiments, when neither a hydrophobic porous material nor a self-sealing material is provided, as shown in FIG. 2, a miniature one-way valve 117 insulating shell may also be provided at the position of the hole 114 The one-way valve 117 is provided with an elastic structure on both the inside and outside of the body 11. When the bristle is not pushed by the bristles, the miniature one-way valve 117 covers the hole 114 to isolate the inside and outside of the housing 11 from the liquid. When the bristle is pushed, the elastic structure deforms, causing the miniature one-way valve 117 to leave or partly leave the hole 114 to allow the bristles to protrude from the hole 114, and when the bristles return to the housing 11, the miniature one-way The elastic structural deformation of the valve 117 is restored, and the micro check valve 117 covers the hole portion 114 again.

It can be understood that in other embodiments, at least a partial area of the housing 11 may also be provided with a dissolvable material that, after entering the human body, dissolves under the action of body fluids, thereby exposing the underlying layer (such as hydrophobic porous Material layer, self-sealing material layer or other material layer), or the above-mentioned hole portion 114 is formed.

It can be understood that, in other embodiments, the means for isolating the liquid inside and outside the housing 11 may also use two or more of the above solutions. For example, a hydrophobic porous material layer may be provided on the housing 11 or a self-sealing material. The hydrophobic porous material layer and the self-sealing material may also be stacked on each other.

The actuation module 13 includes an actuation unit 131, a control unit 132, and an energy unit 133. The actuation unit 131 may be a motor, such as a micromotor, or a transmission component driven by the integrated motor. The control unit 132 may be a micro control chip, and the energy unit 133 may be a battery, such as a micro battery. The actuation unit 131, control unit 132 and energy unit 133 are all integrated on a circuit board 134, and are electrically connected to each other through the circuit board 134. For example, the energy unit 133 supplies power to the actuation unit 131 and the control unit 132 through the circuit board 134. The control unit 132 controls the power supply of the energy unit 133 to the actuation unit 131 through the circuit board 134, such as turning on or off the actuation unit 131 To start or stop the actuation unit 131. Of course, according to specific needs, other components may also be provided on the circuit board 134.

The control unit 132 runs a control program. In this embodiment, the control unit 132 runs the control program to control the actuation unit 131 to start intermittently. For example, after the user swallows the sampling device 1, the control unit 132 The actuation unit 131 is activated for a period of time, such as one hour, and the actuation unit 131 is controlled to operate for a duration, such as 5 minutes. Of course, the actuation module 13 may further include a sensing unit (not shown), for example, a temperature sensing unit, which utilizes the temperature difference between the inside and outside of the body to sense whether the sampling device 1 has been swallowed by the user. The pH detection unit uses the detected pH value to determine whether the sampling device 1 has reached a specific location, such as the stomach.

As shown in FIG. 3, the actuation module 13a in another embodiment further includes a wireless communication unit 135, which is disposed on the circuit board 134, and communicates with an external controller through Bluetooth, WIFI and other technical means 2 Communicate. For example, the wireless communication unit 135 may receive an instruction sent by the external controller 2, transmit the instruction to the control unit 132, and the control unit 132 parses and executes the instruction. In a specific case, the external controller 2 may send "start" and "stop" control instructions to the actuation module 13, and the wireless communication unit 135 receives the "start" control sent by the external controller 2. After the instruction, the control instruction is transmitted to the control unit 132, and the control unit 132 starts the operation of the actuation unit 131 according to the control instruction. After receiving the "stop" control instruction sent by the external controller 2, the wireless communication unit 135 sends the control instruction It is transmitted to the control unit 132, and the control unit 132 stops the operation of the actuation unit 131 according to the control instruction. In another specific case, the external controller 2 may also transmit other control parameters to the actuation module 13, for example, parameters indicating how often to activate the actuation unit 131, and / or instructing the actuation unit 131 each time Parameters such as how long the startup lasts.

Referring to FIG. 4, the actuating module 13b in an embodiment further includes a positioning unit 136, which is used to obtain positioning information of the sampling device 1 and send the positioning information to the wireless communication unit 135 The external controller 2 analyzes the positioning information of the sampling device 1 and obtains the location information of the sampling device 1. Further, the external controller 2 can generate corresponding control instructions and / or control parameters according to the position information of the sampling device 1. For example, the external controller 2 activates the actuation unit 131 through the control unit 132 only when the sampling device 1 is located in the area where the target sample needs to be brushed, such as the stomach, and the external controller 2 when the sampling device 1 is located in another location The operation of the actuation unit 131 is stopped by the control unit. As another example, when the sampling device 1 is located in some key parts, such as the stomach, the external controller 2 may send corresponding control parameters to the control unit 132, so that the control unit 132 controls the actuation unit 131 to start more frequently or last longer each time To run. However, when it is located in a non-emphasis site, such as the intestine, the external controller 2 can enable the control unit 132 to control the actuation unit 131 to reduce the number of starts or the duration of each operation.

The positioning unit 136 can obtain the positioning information of the sampling device 1 by using a magnetic field, for example, a magnetic target real-time positioning and tracking system based on a three-axis magnetic sensor array. Alternatively, the positioning unit 136 can also use an optical sensor such as a camera or the like to transmit images of the surrounding environment of the sampling device 1 to generate positioning information of the sampling device 1. Furthermore, the positioning unit 136 can also obtain positioning information of the sampling device 1 using wireless radio frequency positioning technology .

Please refer to FIGS. 1, 5 and 6. In this embodiment, the housing 11 is in the shape of a capsule. The housing 11 is provided with a plurality of holes 114 corresponding to the positions of the bristles. The regular arrangement can also be an irregular arrangement. The diameter of the hole is approximately 10um-3mm, and the diameter of the bristles is 5um-1mm. The attachment 122 is disposed at the position of the central axis of the housing 11, and the bristles extend from the periphery of the attachment 122 toward the housing 11. The length of the bristles is larger than the size of the attachment 122 to reach the housing 11. The portion 114 is preferably extended. The attachment 122 rotates under the actuation of the actuating module 13, and the bristles follow the attachment 122. When the end of the bristle reaches the position of the hole 114, it protrudes from the hole 114 to brush the target sample. After the bristles are taken away from the position of the hole 114 according to the attachment 122, the ends of the bristles are forced to retract into the housing 11.

It can be understood that the bristles do not necessarily need to cover the periphery of the attachment 122. In other embodiments, the bristles may only be located in a part of the periphery of the attachment 122. The hole 114 does not cover all the areas of the housing 11 corresponding to the first chamber 111, and the hole 114 may only be located within a small range. In short, the distribution area of the bristles and the hole portion 114, the size of the distribution area, and the distribution rule can be set according to specific needs, only the bristles can be extended from the hole portion 114 under the actuation of the actuating module 13 to take the target sample, Then, it can be retracted into the housing 11 under the actuation of the actuation module 13.

It can be understood that the diameters of the bristles and the holes 114 are not limited to the values provided above. The diameters of the bristles and the holes 114 can also be changed according to actual needs. Only the bristles can be removed from the holes 114 under the actuation of the actuation module 13 Just extend it. In addition, the hole portion 114 is not necessarily a circular hole, and it may be an elongated hole or a hole of another shape. For example, in one embodiment, the hole portion 114 may be an elongated hole extending in the direction of rotation of the bristles.

Please refer to FIGS. 7A and 7B. In the embodiment shown in FIGS. 7A and 7B, the attachment 122 drives the bristles to swing in at least one direction under the actuation of the actuation module 13, for example, with a housing For reference, the central axis of the housing 11 is set as the front-rear direction, and the surroundings of the central axis of the housing 11 are up, down, left, and right directions respectively. According to the attachment 122, under the actuation of the actuation module 13, Drive the bristles to swing only upward, only downward, only to the left, and only to the right, or to move the bristles up and down, left and right, or up and down and left and right in a certain order, so that the bristles extend from the corresponding holes 114 Out.

When the attachment 122 drives the bristles to oscillate in only one direction, or drives the bristles to oscillate in two directions but the two directions are not opposite directions, the attachment 122 may not need to be disposed along the central axis of the housing 11.

Please refer to FIGS. 8A and 8B. In the embodiment shown in FIGS. 8A and 8B, the end of the housing 11a corresponding to the sampling module 12a is substantially tapered, and the length of the bristles of the bristle portion 121a also gradually becomes shorter. According to the trend, the actuation module 13 actuates to move back and forth according to the attachment 122. During the movement, the longer bristles extend from the hole 114 at the smaller diameter of the housing 11a to take a sample of the brush, and then retract the housing 11a Inside.

Please refer to FIGS. 9A and 9B. In the embodiment shown in FIGS. 9A and 9B, the sampling module 12b includes a bristle portion 121 and an attachment 122a. The attachment 122a is made of a retractable material. The actuating module 13 Drive the volume of the attachment 122a to increase or decrease. For example, the actuating module 13 may include a gas source (not shown), and increase or decrease the volume of the attachment 122a by adding or subtracting gas into the attachment 122a. When the volume of the attachment 122a increases, the bristles are driven to extend from the hole 114, and when the volume of the attachment 122a decreases, the bristles are driven to retract into the housing 11.

It can be understood that the attachment 122a may not be made of an elastic material, but the size and volume of the attachment 122a are changed by structural design, thereby changing the distance between the bristles and the corresponding hole 114.

The following exemplifies the application of the sampling device 1 to the sampling of cells in the digestive tract to further illustrate the present invention.

After the user swallows the sampling device 1, the sampling device 1 automatically starts the control unit 132 to run the control program according to the sensed temperature change or other parameters, or the sampling device 1 starts the control unit 132 to run the control program according to the control instruction sent by the external controller 2. The actuation unit 131 is started and stopped intermittently. The actuating unit 131 actuates the sampling module 12 so that the bristles of the sampling module 12 extend out of the housing 11 (or 11a) to brush the target sample, and then the actuating unit 131 drives the sampling module 12 to retract the bristles into the housing 11 (or 11a) Inside, the target sample taken by the bristle brush is stored in the housing 11 (or 11a), and the protective solution or buffer 115 in the housing 11 (or 11a) maintains the activity of the target sample or prevents the target sample from being destroyed. Finally, the sampling device 1 is excreted with the feces, the sampling device 1 is recovered, and DNA sequencing of the target sample in the sampling device 1 can realize the screening and detection of diseases such as early cancer and the collection of specimens for other purposes.

The sampling device and the gastrointestinal sampling capsule provided by the embodiment of the present invention drive the sampling module to extend out of the body to brush the target sample, and the brushed target sample is stored in the sampling device, thus not only avoiding traditional disease screening and specimen collection The pain that is imposed on the user at the time, and the number of collected cells can meet the needs more than the in vitro collection, which is convenient and easy to implement.

Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be Modifications or equivalent replacements are made without departing from the spirit and scope of the technical solutions of the present invention.

Claims

A sampling device, characterized in that it includes:

case;

A sampling module, which is placed in the housing and used to extend out of the housing to obtain a target sample; and

The actuation module is placed in the housing and is used to drive the sampling module to extend or retract the housing.
The sampling device according to claim 1, wherein a protective liquid or a buffer solution is stored in the housing, and a target sample obtained by the sampling module is stored in the protective liquid or the buffer solution.
The sampling device according to claim 1, wherein a hole is formed in the casing, and the sampling module extends out of the casing through the hole to obtain a target sample.
The sampling device according to claim 3, wherein the whole or partial area of the housing includes at least one layer of hydrophobic porous material, and the layer of hydrophobic porous material is used to isolate the protection liquid or the buffer liquid from The external liquid, or the whole or partial area of the housing includes at least one layer of hydrophobic porous film, and the hydrophobic porous film is used to isolate the protective liquid or the buffer liquid from the external liquid.
The sampling device according to claim 3 or 4, characterized in that a check valve is provided at the location of the hole to cover the hole, and the check valve is pushed away or partially away from the hole by the sampling module To allow the sampling module to extend out of the housing, and after the sampling module is retracted into the housing, the one-way valve covers the hole again.
The sampling device according to claim 2 or 3, wherein the whole or partial area of the housing further comprises at least one layer of self-closing material, and the sampling module passes through the housing in the self-closing material The hole formed on the layer is automatically closed after the sampling module is retracted into the housing.
The sampling device according to claim 1, wherein a dissolvable material layer is further provided in the whole or partial area of the housing, and the dissolvable material layer is dissolved after entering the human body.
The sampling device according to claim 1, wherein the sampling module includes a bristle portion and an attachment attached to the bristle portion, and the actuation module drives the attachment to swing and rotate up and down and / or left and right Or move back and forth to expose the bristles of the bristle portion from the housing or retract the housing; or, the actuation module drives the volume of the attachment to increase or decrease, so that the bristle portion The bristles are exposed from the casing when the volume of the attachment is increased, and retracted into the casing when the volume of the attachment is reduced.
The sampling device according to claim 1, wherein the actuation module includes an actuation unit, a control unit that controls the actuation unit, and an energy unit that provides energy to the actuation module as a whole. The moving unit is electrically connected to the sampling module, and drives the sampling module to extend or retract under the control of the control unit.
The sampling device according to claim 9, wherein the actuating module further comprises a wireless communication unit for establishing a communication connection with an external controller, and the control unit receives the external device through the wireless communication unit The controller commands to start or stop the actuation unit.
The sampling device according to claim 10, further comprising a positioning unit configured to provide positioning information to the external controller through the wireless communication unit for the external controller to obtain The location of the sampling device.
The sampling device according to claim 1 or 2, wherein at least two chambers are provided inside the sampling device, the two chambers are sealed and separated, and the actuating module is provided in one of the chambers Indoors, the sampling module is placed in another chamber.
The sampling device according to claim 3, wherein at least two chambers are provided inside the sampling device, the two chambers are sealed and separated, and the actuation module is provided in one of the chambers, The sampling module is disposed in another chamber, and the hole portion is opened on the housing corresponding to the chamber where the sampling module is located.
The sampling device according to claim 1, wherein the sampling device is a body sampling device, or the sampling device is a gastrointestinal sampling device, or the sampling device is a capsule shape.
A digestive tract sampling capsule, characterized in that the sampling capsule includes an actuation module and a bristle portion that is driven by the actuation module to extend and retract the sampling capsule to brush the target sample and save the target sample Inside the sampling capsule.
The sampling capsule according to claim 15, wherein the sampling capsule stores a protective solution or a buffer solution, and the brushed target sample is stored in the protective solution or the buffer solution.
The sampling capsule according to claim 16, wherein the sampling capsule is provided with a device or material that isolates the protective liquid or the buffer liquid from the external liquid.
The sampling capsule according to claim 17, wherein a hole portion is formed in the sampling capsule, the bristle portion extends and retracts into the sampling capsule through the hole portion, and the isolation liquid is protected Or the device or material of the buffer and the external liquid is a one-way valve covering the hole portion, the one-way valve is pushed away or partially away from the hole portion by the bristle portion to allow the bristle portion to extend out In the housing, after the bristle portion is retracted into the housing, the one-way valve covers the hole portion again.
The sampling capsule according to claim 17, wherein the device or material that isolates the protection liquid or the buffer liquid from the external liquid is a self-sealing material layer, and the self-sealing material layer is used for the bristle portion to puncture through , And after the bristle portion is retracted into the sampling capsule, the hole portion formed by the puncture of the bristle portion is automatically closed to isolate the protective liquid or the buffer liquid from the external liquid.
The sampling capsule according to claim 17, wherein the device or material separating the protection liquid or the buffer liquid from the external liquid is a hydrophobic porous material layer or a hydrophobic porous film.
The sampling capsule according to claim 16, wherein the sampling capsule is wrapped with a layer of soluble material, and the layer of soluble material is dissolved after entering the human body.