CN113171358A

CN113171358A - Pet chewing gum based on alginate soft capsules

Info

Publication number: CN113171358A
Application number: CN202110485006.2A
Authority: CN
Inventors: 吕豪
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-04-30
Filing date: 2021-04-30
Publication date: 2021-07-27

Abstract

The invention provides a pet chewing gum based on alginate soft capsules, and belongs to the technical field of oral cleaning and nursing products. The pet bait uses the self motility of pets, uses the shell formed by the phagostimulant to wrap the medicine-containing soft capsules and the enteric-coated microcapsules to lure the pets to use actively, uses the medicine-containing soft capsules to bring the antibacterial medicine into the oral cavity of the pets, and then uses the enteric-coated microcapsules to bring the pet probiotics and the prescription medicine into the small intestines of the pets for absorption and utilization. The invention fully utilizes the motility of pets, combines the phagostimulant, the alginate medicine-containing soft capsules and the enteric-coated microcapsules, prepares the novel multifunctional pet chewing gum which only needs to be fed manually and does not need to participate too much, and has the advantages of convenient use, suitability for pet groups, and the like.

Description

Pet chewing gum based on alginate soft capsules

Technical Field

The invention belongs to the technical field of oral cleaning and nursing products, particularly relates to a novel pet chewing gum, and particularly provides a pet chewing gum based on alginate soft capsules.

Background

Animal and human teeth are quite similar, from tissue structure to jaw bone structure. However, because animals cannot always clean their mouths actively, long-term food residues adhere to the tooth surfaces and accumulate to form tartar, and bacteria are continuously propagated, so that gingivitis, periodontitis, dental calculus and the like are caused, and halitosis, redness and swelling of the gums and even kidney diseases are caused. Bad breath of the pet can also influence the feeding experience of a pet owner, so the oral cavity nursing care has important significance. In addition, the long-term consistency of the fed food of the domestic pet causes unbalanced dietary nutrition and lack of B vitamins, further increases the risk of oral ulcer or erosion of the pet, is often accompanied by halitosis, salivation and chewing disorder in severe cases and immunodeficiency, reduces the food consumption of animals, even refuses to eat, and seriously affects the gastrointestinal function.

At present, the oral cleaning product for pets has the following problems: (1) the toothpaste for pets: the toothpaste for the human is developed and converted, the using principle and method and the toothpaste for the human do not have two qualities, the situation that the pet is not matched always occurs in the using process, the using environment always needs manual intervention, and the activity of the pet is not fully utilized; (2) chewing gum for pet: chewing gum for pets is also used for humans as a weaning chewing gum, which requires chewing to be effective, and this approach is well suited for canine pets, but is essentially ineffective for feline pets, because felines swallow the food, have no posterior sockets, have no chewing process, and the dental and jaw-biting actions only serve to cut food, and thus the chewing gum is ineffective for felines. The american society of veterinary and medicine indicates that more than 70% of cats in about three years have oral diseases, and that the problems of gingival inflammation and oral mucosal hyperplasia in cats, especially in older cats, are common and serious, and that digestive function is affected in cats with oral diseases, thereby shortening their life.

In addition, the birth of the existing breed cat is often accompanied with close reproduction, so that the physique and the resistance of the cat are poor, and the cat is very easy to get ill. The use of prescription drugs is frequent in breed cats once they are ill, and the convenient feeding of cats is also a problem. Furthermore, the species cat also needs to regularly expel insects in vivo and in vitro, but the existing method for feeding the insect repellent in the pet body still uses a medicine feeder which is very troublesome when in use, is particularly unfriendly to common new promotion pet owners, and has the condition of scratching by pet cats in the process of the pet owners. According to statistics, by 2020, the number of pet cats reaches 4862, and how to scientifically feed the pet cats and perform effective oral care is particularly important.

Disclosure of Invention

In order to solve the problems that the existing pet oral cavity cleaning products and medicines are harsh in use conditions and limited in use objects, the invention aims to provide the pet chewing gum based on the alginate soft capsules, the chewing gum can play a cleaning role without chewing, and is also effective for animals such as cats who eat the chewing gum.

In order to achieve the technical purpose, the inventor utilizes the motility of pets, utilizes the shell formed by the phagostimulant to wrap the medicine-containing soft capsule and the enteric-soluble microcapsule to lure the pets to use actively, utilizes the medicine-containing soft capsule to bring the antibacterial medicine into the oral cavity of the pets, and then utilizes the enteric-soluble microcapsule to bring the probiotics and the prescription medicine of the pets into the small intestines of the pets for absorption and utilization. The process only needs feeding manually, does not need excessive participation, and has the characteristics of convenient use, suitability for pet groups, and the like. Specifically, the technical scheme of the invention is summarized as follows:

a pet chewing gum based on alginate soft capsules comprises a food calling layer, enteric microcapsules and medicine-containing soft capsules, wherein the enteric microcapsules and the medicine-containing soft capsules are wrapped by the food calling layer;

the food calling layer is prepared from the following components in percentage by mass: 2-12% of liver powder, 4-22% of pumpkin powder, 1-23% of gel, 5-33% of milk powder, 0.05-0.13% of taurine and the balance of water (preferably 2-5% of liver powder, 4-10% of pumpkin powder, 2-8% of gel, 10-20% of milk powder, 0.05-0.13% of taurine and the balance of water); the gelling agent is selected from any one of the following: geliding powder, agar, rhizoma arisaematis powder, and white bean jelly;

the enteric microcapsule consists of a wall material and a core material, wherein the wall material is sodium alginate and chitosan and is formed by solidifying calcium ions, and the core material is selected from at least one of the following materials: probiotics, anthelmintics, antibiotics.

The medicine-containing soft capsule consists of a wall material and a core material, wherein the wall material is sodium alginate and is formed by solidifying calcium ions, and the core material is prepared from methylthioadenosine, citronellaic acid, vitamin B1, vitamin B2 and vitamin B3 according to the weight ratio of (0.5-2): (1-3): (2-4): (2-4): (2-4) mass ratio. (preferably, the core material consists of methylthioadenosine, citronellic acid, vitamin B1, vitamin B2 and vitamin B3 according to the mass ratio of 1: 2: 3: 3: 3).

Further preferably, the alginate soft capsule based pet chewing gum as described above, wherein said chewing gum is a cube with sides of 12-20 mm; the enteric microcapsule is spherical or sphere-like, and has a diameter of 0.6-1mm, which can be less than 0.6 mm; the soft capsule containing medicine is spherical or quasi-spherical, and the diameter is 9-11 mm.

Further preferably, the pet chewing gum based on the alginate soft capsules is characterized in that the number of the enteric microcapsules is 10-100, and the number of the medicine-containing soft capsules is 1.

Further preferably, said alginate soft capsule based pet chewing gum as described above, wherein said liver powder is selected from chicken liver powder or/and bovine liver powder.

Further preferably, the pet chewing gum based on alginate soft capsules as described above, wherein said probiotics comprise bacillus subtilis, saccharomyces cerevisiae, streptococcus thermophilus and bifidobacterium animalis.

Further preferably, the alginate soft capsule based pet chewing gum as described above, wherein said anthelmintic is selected from at least one of the following: praziquantel, pyrantel pamoate and ivermectin.

Further preferably, the alginate soft capsule based pet chewing gum as described above, wherein said antibiotic is selected from at least one of the following: cephalosporin antibiotics, azithromycin and amoxicillin.

In addition, the invention also provides a preparation method of the pet chewing gum based on the alginate soft capsules, which comprises the following steps:

(1) adding the gel into cold boiled water, and mixing the water and the gel in a ratio of (4-5): 1, soaking in water for 5-6min, and heating and dissolving in water bath at 40-45 ℃ to obtain a gel solution;

(2) mixing pumpkin powder, liver powder and milk powder, adding taurine, stirring, adding the gel solution obtained in the step (1), stirring, and mixing completely, heating and stirring to 38-40 ℃ for later use;

(3) preparing two parts of L-calcium lactate solution with the mass percentage of 0.8-1.2% for later use;

(4) dissolving methylthioadenosine, citronellac acid, vitamin B1, vitamin B2 and vitamin B3 in water, adding sodium alginate, stirring, sealing and storing until the sodium alginate is completely dissolved to obtain a mixed solution;

(5) dripping the mixed solution obtained in the step (4) into a part of the L-calcium lactate solution prepared in the step (3) to prepare a medicine-containing soft capsule with a bead shape of 9-11mm in diameter, fishing out after 5-7 seconds, and cleaning with clear water for later use;

(6) mixing probiotic bacteria powder or/and anthelmintic or/and antibiotic with water, adding sodium alginate solution, and stirring to obtain mixed solution;

(7) dripping the mixed solution obtained in the step (6) into the other part of the L-calcium lactate solution prepared in the step (3) to prepare a drug-containing microcapsule with the diameter of 0.6-1mm, and fishing out after 5-7 seconds;

(8) adding the fished medicine-containing microcapsule into 0.8-1.3% chitosan solution by mass percent for re-emulsification, stirring for 25-40 minutes, centrifuging, and vacuum drying at 3-4 ℃ to prepare enteric microcapsule;

(9) adding the enteric microcapsule obtained in the step (8) into the mixed solution obtained in the step (2), and stirring uniformly;

(10) and (4) putting the soft capsule containing the medicine obtained in the step (5) into a mould, then adding the feed liquid obtained in the step (9), and cooling and forming to obtain the pet chewing gum.

Compared with the prior art, the pet chewing gum based on the alginate soft capsules provided by the invention has the following advantages and remarkable progress:

(1) the soft feces is the longest problem in the pet cat breeding process, and the main reason causing the soft feces of the pet cat is gastrointestinal dysfunction. The probiotics are prepared into the enteric-coated microcapsules, can pass through gastric acid to reach small intestines, and can be naturally disintegrated under the alkaline condition of the small intestines to release an embedded object, so that the intestinal microecological balance of the pet cat is improved, and the curative effect of treating the soft stool is achieved.

(2) The methylthioadenosine has growth inhibiting effect on oral harmful bacteria such as Streptococcus mutans, Actinomyces viscosus, carbon dioxide Cellophilus gingivalis and Fusobacterium nucleatum; the citronellaic acid has the effect of inhibiting the growth of intestinal pathogenic bacteria staphylococcus aureus and escherichia coli, and has a good killing effect on oral mites. The methionine adenosine and the citronellac acid are used together as active ingredients of the pet chewing gum, and can bring bacteriostatic and antibacterial synergistic effects to pet cats suffering from oral inflammation.

(3) The invention fully utilizes the motility of pets, combines the phagostimulant, the alginate medicine-containing soft capsules and the enteric-coated microcapsules, prepares the novel multifunctional pet chewing gum which only needs to be fed manually and does not need to participate too much, and has the advantages of convenient use, suitability for pet groups, and the like.

Detailed Description

The following are specific examples of the present invention, and further description is made on the technical solutions and technical effects of the present invention, but the scope of the present invention is not limited to these examples. All changes, modifications and equivalents that do not depart from the spirit of the invention are intended to be included within the scope thereof.

Example 1: preparation of phagostimulant

(1) Under the condition of room temperature, adding 50.00g of Geliding D powder into a 500ml beaker, adding 221ml of cold boiled water, soaking in water for 5-6min, and heating and dissolving in a water bath at 40-45 ℃ to obtain a Geliding D solution;

(2) adding 443ml of cold boiled water into the Jilibuding solution obtained in the step (1), uniformly mixing 90.00g of pumpkin powder, 24.50g of beef liver powder, 171.00g of milk powder and 0.50g of taurine, adding the mixture into the prepared Jilibuding solution, uniformly stirring, heating and stirring to 38-40 ℃ after completely and uniformly mixing.

(3) Pouring into a mold with the size of 144-400 cubic millimeters, and cooling and molding at 4 ℃.

Example 2: preparation of phagostimulant

(2) adding 443ml of cold boiled water into the Jilibuding solution obtained in the step (1), uniformly mixing 90.00g of pumpkin powder, 24.50g of chicken liver powder, 171.00g of milk powder and 0.50g of taurine, adding the mixture into the prepared Jilibuding solution, uniformly stirring, heating and stirring to 38-40 ℃ after completely and uniformly mixing.

Example 3: preparation of chewing gum for pet

(2) adding 443ml of cold boiled water into the Jilibuding solution obtained in the step (1), uniformly mixing 90.00g of pumpkin powder, 24.50g of beef liver powder, 171.00g of milk powder and 0.50g of taurine, adding the mixture into the prepared Jilibuding solution, uniformly stirring, heating and stirring to 38-40 ℃ after completely uniformly mixing, and keeping for later use;

(3) preparing two L-calcium lactate solutions with the mass percentage of 1% for later use;

(4) dissolving sodium alginate 30g in 958ml water, adding methionine 1g, citronellac acid 2g, vitamin B13g, vitamin B23g, vitamin B33g, mixing well, sealing and storing, and obtaining mixed solution after the sodium alginate is completely dissolved;

(5) sucking the mixed solution obtained in step (4) with a dropper with a diameter of 4-6mm, squeezing at a distance of 10-20mm from the liquid level, dropping into 1% L-calcium lactate solution (250ml), making into medicine-containing soft capsule with diameter of 9-11mm, taking out after 5-7 s, and cleaning with clear water;

(6) respectively sieving 75g of bacillus subtilis powder, 75g of saccharomyces cerevisiae powder, 75g of streptococcus thermophilus powder and 75g of bifidobacterium animalis bb-12 powder with a 20-mesh sieve, uniformly mixing, adding 500ml of water for mixing, then adding 500ml of sodium alginate solution (4 mass percent), and uniformly stirring and mixing to obtain a mixed solution;

(7) dripping the mixed solution obtained in the step (6) into 1% L-calcium lactate solution (250ml) by using a dropper or a dispensing tube with the inner diameter of less than 0.94mm by adopting an extrusion method to prepare medicine-containing microcapsules with the diameter of less than 1mm, and fishing out after 5-7 seconds;

(8) adding the fished medicine-containing microcapsule into enough chitosan solution with the mass percent of 1% for re-emulsification, stirring for 30 minutes, centrifuging, and carrying out vacuum drying at the temperature of 4 ℃ to prepare enteric-coated microcapsules;

(9) adding the 15 enteric microcapsules obtained in the step (8) into the mixed liquid obtained in the step (2), and uniformly stirring;

(10) and (4) putting the medicine-containing soft capsule obtained in the step (5) into a mold with the size of 144-400 cubic millimeters, then adding the material liquid obtained in the step (9), and cooling and forming at 4 ℃ to obtain the pet chewing gum.

Comparative example 1: preparation of chewing gum for pet (without citronellac acid)

The steps and parameters other than step (4) were the same as those in example 3.

(4) Dissolving sodium alginate 30g in 958ml water, adding methionine 1g, vitamin B13g, vitamin B23g, and vitamin B33g, mixing, sealing, and storing until sodium alginate is completely dissolved to obtain mixed solution.

Comparative example 2: preparation of Pet chewing Gum (methionine free adenosine)

(4) Dissolving sodium alginate 30g in 958ml water, adding citronellal acid 2g, vitamin B13g, vitamin B23g, vitamin B33g, mixing well, sealing and storing, and obtaining mixed solution after the sodium alginate is completely dissolved.

Example 4: judgment of attracting or palatability of pet chewing gum (double basin method)

The double-pot method is a common development for determining palatability internationally at present, and comprises the steps of respectively providing A, B two kinds of foods with the same amount to a group of pets (all cats or all dogs), feeding the pets freely within a certain time, respectively recording consumption rates of the pets to A, B, and consuming high palatability (consumption rate A is consumption of food A in a certain time/total amount of A, B two kinds of foods).

We chose 6 male puppet cats aged 2-4 years, examined two weeks in advance, repelled and then fed in pet cat cages (3m × 1m × 2 m). Before feeding, freely drinking water, replacing cat litter every day, cleaning the cat house and cleaning the cat house to keep the cat house clean. All procedures were performed after the cats had fasted overnight. Because the adult puppet cat eats between 100-200g per meal, the interference is eliminated, and the adult puppet cat feeds 250g per meal. The experiments were averaged 6 times, each one week apart.

TABLE 1 palatability comparison experiment of different ingredient phagostimulants

The experimental result shows that the palatability of the food calling system using the beef liver formula is better.

Example 5: evaluation of bacteriostatic agent Effect in Pet chewing Gum

12 pet cats with oral inflammation were selected and randomly divided into four groups of 3 cats, each group being designated as one, two, three, and four groups. Oral mucosa, tongue and gum secretion samples are collected for each group of pet cats by a sampling swab, and 23 kinds of bacteria are obtained in the oral secretions of all pet cats after separation and identification. The pathogenicity experiment proves that 3 of the bacteria have pathogenicity, and the pathogenicity is respectively as follows: staphylococcus, streptococcus, pasteurella.

And feeding the chewing gum for the pet after the pet cat eats for half an hour. Feeding continuously for 14 days. One group was fed nothing, two groups were fed with the chewing gum prepared in example 3, three groups were fed with the chewing gum prepared in comparative example 1, and four groups were fed with the chewing gum prepared in comparative example 2.

After 14 days, oral mucosa, tongue and gingival secretion samples were collected from the oral cavities of five groups of pet cats by sampling swabs, and the sample flora was isolated, and the results are shown in table 2 (when the total number of colonies is less than 10CFU/g, the colonies were regarded as not detected).

Table 2: evaluation of antibacterial effect of pet chewing gum

Pathogenic bacteria	A group of	Two groups are	Three groups	Four groups
					Streptococcus sp	Detect out	Not detected out	Not detected out	Detect out
Pasteurella	Detect out	Not detected out	Not detected out	Detect out
					Staphylococcus aureus	Detect out	Not detected out	Detect out	Not detected out

As can be seen from the experimental results of Table 2, the pet cats fed the chewing gum of example 3 did not detect 3 pathogens, while the pet cats fed the chewing gum of comparative example 1 detected staphylococci, and the pet cats fed the chewing gum of comparative example 2 detected streptococci and Pasteurella, indicating that methylthioadenosine and citronellac acid have a synergistic killing effect on the pathogens of oral inflammation in the pet cats.

Claims

1. A pet chewing gum based on alginate soft capsules is characterized in that the chewing gum consists of a food calling layer, enteric microcapsules and medicine-containing soft capsules, wherein the enteric microcapsules and the medicine-containing soft capsules are wrapped by the food calling layer;

the food calling layer is prepared from the following components in percentage by mass: 2-12% of liver powder, 4-22% of pumpkin powder, 1-23% of gel, 5-33% of milk powder, 0.05-0.13% of taurine and the balance of water; the gelling agent is selected from any one of the following: geliding powder, agar, rhizoma arisaematis powder, and white bean jelly;

The medicine-containing soft capsule consists of a wall material and a core material, wherein the wall material is sodium alginate and is formed by solidifying calcium ions, and the core material is prepared from methylthioadenosine, citronellaic acid, vitamin B1, vitamin B2 and vitamin B3 according to the weight ratio of (0.5-2): (1-3): (2-4): (2-4): (2-4) mass ratio.

2. The alginate soft capsule-based pet chewing gum of claim 1, wherein said chewing gum is a cube having a side length of 12-20 mm; the enteric microcapsule is spherical or sphere-like, and the diameter is 0.6-1 mm; the soft capsule containing medicine is spherical or quasi-spherical, and the diameter is 9-11 mm.

3. The alginate soft capsule-based pet chewing gum according to claim 1, wherein the number of said enteric microcapsules is 10-100, and the number of said drug-containing soft capsules is 1.

4. The alginate soft capsule-based pet chewing gum according to claim 1, wherein said liver powder is selected from chicken liver powder or/and bovine liver powder.

5. The alginate soft capsule-based pet chewing gum of claim 1, wherein said probiotics include bacillus subtilis, saccharomyces cerevisiae, streptococcus thermophilus, and bifidobacterium animalis.

6. The alginate soft capsule-based pet chewing gum of claim 1, wherein said anthelmintic is selected from at least one of the following: praziquantel, pyrantel pamoate and ivermectin.

7. The alginate soft capsule-based pet chewing gum according to claim 1, wherein said antibiotic is selected from at least one of the following: cephalosporin antibiotics, azithromycin and amoxicillin.

8. The pet chewing gum based on the alginate soft capsules according to claim 1, wherein the food calling layer is prepared from the following components in percentage by mass: 2-5% of liver powder, 4-10% of pumpkin powder, 2-8% of gel, 10-20% of milk powder, 0.05-0.13% of taurine and the balance of water.

9. The pet chewing gum based on the alginate soft capsule, according to claim 1, is characterized in that the drug-containing soft capsule consists of a wall material and a core material, wherein the wall material is sodium alginate and is formed by solidifying calcium ions, and the core material is formed by mixing methionine adenosine, citronellaic acid, vitamin B1, vitamin B2 and vitamin B3 in a ratio of 1: 2: 3: 3: 3 in mass ratio.

10. The alginate soft capsule based pet chewing gum according to claim 1, wherein a method for preparing the alginate soft capsule based pet chewing gum according to claim 1 comprises the following steps: