JPH119196A - Prevention of loss in livestock with chitosan - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prevent a loss in livestock by preventing infectious diseases by orally administering chitosan. SOLUTION: Chitosan is orally administered to prevent infectious diseases. Although the infectious diseases vary with the livestock, the diseases include all thereof in which microorganisms invade a biological host, colonize and proliferate. Effects are recognized in prevention of the infectious diseases in especially respiratory and digestive organs among the infectious diseases. Although cattle, a horse, a pig and a chicken, etc., are cited as the livestock, there is no special limitation. Preventing effects on the infectious diseases are strongly recognized in livestock deteriorated in immune strength in mature livestock or young livestock weak in the immune strength. Further, the preventing effects on the infectious diseases are remarkable in calves.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a method for preventing livestock abrasion, and more particularly to a method for preventing livestock abrasion by orally administering chitosan to livestock to prevent infectious diseases.

[0002]

2. Description of the Related Art Chitosan is a natural polysaccharide and is obtained by deacetylation of chitin, which is usually obtained from crustacean and shrimp shells, by alkali treatment, enzyme treatment, or the like. More specifically, using crab and shrimp as raw materials, chitin excluding protein and calcium is further deacetylated, and the degree of deacetylation (the ratio of glucosamine residues in the sugar chain) is 50% or more.
It is one that has become soluble in dilute acid.

[0003] In order to prevent infectious diseases in livestock, a method of adding an additive to livestock feed has conventionally been used. 52-
130925, JP-A-54-52731, JP-A-54-70289, JP-A-55-1607
67), lactic acid bacteria (JP-A-07-126178), yeasts (JP-A-08-126178)
283175), and fermented milk of colostrum (JP-A-55-19002) are known. These methods have problems such as high cost and not always satisfactory in terms of cost effectiveness, or low cost but insufficient effect.

[0004]

Problems to be solved by the present invention Stopping and delaying growth and death of livestock due to pneumonia and bacterial diarrhea are major problems for dairy farmers. In particular, infants after childbirth and after weaning often have pneumonia and bacterial diarrhea, which often results in death. In addition, there are many cases in which growth is delayed due to the onset of this disease, and the economic loss is large. Livestock that have developed pneumonia or bacterial diarrhea are treated with antibiotics and the like, but this leads to an increase in production costs. In addition, antibiotics and the like are added to feed to prevent this disease, but there are problems in terms of workability, cost, and drug holiday. Therefore, there is an urgent need for a measure for preventing livestock abrasion, which can prevent infectious diseases, has no problems in efficacy, workability, cost, and drug holiday.

[0005]

Means for Solving the Problems As a result of intensive studies to solve the above problems, the present inventors surprisingly found that oral administration of chitosan to livestock can prevent infectious diseases. Was completed.

[0006]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail.
The present invention is a method for preventing the consumption of livestock by administering orally chitosan to livestock and preventing infectious diseases. Attrition refers to cessation / delay of growth and death. The type of infectious disease referred to in the present invention varies depending on the livestock,
It refers to all diseases in which microorganisms invade living colonies and colonize and proliferate. Particularly effective in preventing respiratory and digestive tract infections among infectious diseases.

[0007] Livestock as referred to in the present invention include cattle, horses, pigs and chickens, but are not particularly limited. The effect of preventing infectious diseases by chitosan is more strongly observed in livestock with reduced immunity among mature livestock and in young animals with weak immunity. Furthermore, the infectious disease prevention effect is remarkable in calves.

[0008] The form and shape of the oral chitosan preparation of the present invention include tablets, pills, granules, fine granules, powder, semi-solid preparation, liquid preparation,
There are capsules and the like, but they are particularly excellent in that liquids are easy to handle and easy to mix evenly when added to feed.

[0009] As an oral administration method of chitosan, there is a method of directly administering an oral preparation of chitosan to livestock and a method of mixing the oral preparation of chitosan into feed or drinking water and then administering it. 200 to 100 doses of chitosan
0 mg / head / day. The administration period is not particularly limited, but in order to expect the effect, it is necessary to continuously give an oral chitosan or a chitosan-containing feed for a certain period. For example, for the prevention of calf diarrhea or pneumonia, the effect can be exerted by oral administration for 10 to 14 days as shown in the following examples.

[0010]

EXAMPLES The present invention will be described in more detail with reference to the following examples to clarify the effects of the present invention. However, these are merely examples, and the scope of the present invention is not limited by these examples. Absent.

Example 1 (Preparation of liquid oral preparation) Chitosan bulk powder (4 g) was swollen in water (600-700 ml), and acetic acid (2 ml)
Was added to the mixture, and the mixture was dissolved by stirring. The total amount was adjusted to 1 L with water to obtain a chitosan liquid oral preparation. The following examples were used.

Example 2 Three calves aged 7 to 10 days old at T Farm were mixed with 50 mL of an oral chitosan (containing 200 mg of chitosan) twice a day in milk and administered for 1 week (chitosan administration group). As controls, three calves to which chitosan was not administered (control group) were used.
Were artificially infected with Salmonella dublin 10 ⁹ pieces injected intravenously all six horses were observed symptoms of each subsequent individual. The chitosan administration group continued oral administration of chitosan for 2 weeks thereafter.
The control group showed symptoms of pneumonia and was treated with antibiotics. In the chitosan administration group, evacuation continues from feces,
She grew well with little clinical symptoms.

Example 3 A test was carried out on a K pasture with 26 out of 50 calves introduced as a chitosan-administered group and 24 as a control group. For oral chitosan, 50 mL (containing 200 mg of chitosan) was mixed with milk twice a day and administered for 10 to 14 days from the day of introduction. Treatment with antibiotics for diarrhea, pneumonia and the like was performed as usual, and the number of treatments was compared. In the control group, there were cases in which treatment was observed, whereas in the administration group, no cases were treated.

Example 4 To 10 clinically healthy calves (Holstein male) introduced at T farm, 50 mL of chitosan oral preparation (containing 200 mg of chitosan) was mixed with 2 L of milk replacer per cow twice a day. , For 16 days, and the administration effect was compared using 10 mice as a control without chitosan administration. Excretion of diarrheal stool was confirmed in 1 out of 10 animals in the control group, but none of the administration groups showed respiratory and digestive symptoms. The body weight gain during the administration period was 12.1 kg per animal on average in the administration group, and 7.1 kg in the control group, and the body weight gain per day was 426 g and 259 g, respectively.

[0015]

According to the present invention, an oral preparation containing chitosan as an active ingredient or a feed or drinking water containing chitosan is administered to livestock to prevent infectious diseases of the respiratory and digestive systems of the livestock. Can be. Therefore, it is possible to prevent livestock from being worn.

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Fumio Kimura Inventor, Pharmaceutical Research Laboratories, Meiji Seika Co., Ltd., 760 Morioka-cho, Kohoku-ku, Yokohama, Kanagawa Prefecture Address Meiji Seika Co., Ltd., Pharmaceutical Research Laboratory (72) Inventor Juichi Ito 760 Morioka-cho, Kohoku-ku, Yokohama-shi, Kanagawa Prefecture Meiji Seika Co., Ltd. 760 Okamachi Meiji Seika Co., Ltd., Pharmaceutical Research Institute (72) Inventor Takashi Muraoka 4-2-35 Sanbonmatsucho, Kanonji-shi, Kagawa Pref. -2-35 Katoyoshi Bio Co., Ltd. (72) Inventor Takeshi Kenya 3469-65 Ja, Ujiiecho, Shioya-gun, Tochigi Prefecture In an Calf Clinic (72) inventor Kazuo Akiyama Hokkaido Ashoro-gun Rikubetsu MachiAsahi-cho, Tokachi agricultural mutual aid union within the

Claims (7)

[Claims] 1. A method for preventing livestock wear, which comprises administering chitosan orally to livestock to prevent infectious diseases. 2. The method according to claim 1, wherein the animal is prevented from being worn by preventing respiratory and digestive organ infections. 3. Livestock with reduced and weak immunity.
And 2. The method for preventing livestock abrasion described in 2. 4. The method according to claim 3, which is a young animal. 5. The method according to claim 4, wherein the method is a calf. 6. An oral chitosan preparation for use in the method for preventing livestock wear according to claim 1. 7. The oral chitosan preparation according to claim 6, which is a liquid preparation.