CN113167785B - 微流体装置 - Google Patents

微流体装置 Download PDF

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Publication number
CN113167785B
CN113167785B CN201980063512.3A CN201980063512A CN113167785B CN 113167785 B CN113167785 B CN 113167785B CN 201980063512 A CN201980063512 A CN 201980063512A CN 113167785 B CN113167785 B CN 113167785B
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CN
China
Prior art keywords
plasma
metering channel
channel
microfluidic device
region
Prior art date
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Active
Application number
CN201980063512.3A
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English (en)
Chinese (zh)
Other versions
CN113167785A (zh
Inventor
A·奥兰德
H·P·斯塔克-约翰逊
J·豪泽
G·斯特默
N·洛克希德
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Capitenell Corp
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Capitenell Corp
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Publication of CN113167785A publication Critical patent/CN113167785A/zh
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/126—Paper
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
CN201980063512.3A 2018-09-06 2019-09-05 微流体装置 Active CN113167785B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE1830253 2018-09-06
SE1830253-9 2018-09-06
SE1950149 2019-02-08
SE1950149-3 2019-02-08
PCT/SE2019/050837 WO2020050770A1 (en) 2018-09-06 2019-09-05 A microfluidic device

Publications (2)

Publication Number Publication Date
CN113167785A CN113167785A (zh) 2021-07-23
CN113167785B true CN113167785B (zh) 2024-09-03

Family

ID=69721729

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980063512.3A Active CN113167785B (zh) 2018-09-06 2019-09-05 微流体装置

Country Status (5)

Country Link
US (1) US12539513B2 (https=)
EP (1) EP3847458A4 (https=)
JP (1) JP7409693B2 (https=)
CN (1) CN113167785B (https=)
WO (1) WO2020050770A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023277773A1 (en) 2021-06-29 2023-01-05 Capitainer Ab Microfluidic devices
JP2024526232A (ja) 2021-06-29 2024-07-17 キャピテナー アクチボラゲット マイクロ流体装置
WO2024259905A1 (zh) * 2023-06-20 2024-12-26 香港城市大学 用于从全血中提取血浆的微流体装置和方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015044454A2 (en) * 2013-09-30 2015-04-02 Göran Stemme A microfluidic device, use and methods
WO2016209147A1 (en) * 2015-06-20 2016-12-29 Roxhed Niclas A plasma separating microfluidic device

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5147606A (en) * 1990-08-06 1992-09-15 Miles Inc. Self-metering fluid analysis device
US5208163A (en) * 1990-08-06 1993-05-04 Miles Inc. Self-metering fluid analysis device
JP3833830B2 (ja) * 1998-09-01 2006-10-18 富士写真フイルム株式会社 血液成分分離器
JP2003194806A (ja) 2001-12-27 2003-07-09 Minolta Co Ltd 血球分離用チップ
DE102004027422A1 (de) 2004-06-04 2005-12-29 Boehringer Ingelheim Microparts Gmbh Vorrichtung zur Aufnahme von Blut und Abtrennung von Blutbestandteilen
JP4844318B2 (ja) 2006-09-22 2011-12-28 住友ベークライト株式会社 マイクロ流路デバイス
BRPI0907148B1 (pt) 2008-02-27 2021-01-12 Boehringer Ingelheim Microparts Gmbh dispositivo para a separação do plasma
BR112015002555A2 (pt) 2012-08-08 2017-07-04 Koninklijke Philips Nv sistema para a separação de plasma e/ou soro do sangue e método para a separação de plasma e/ou do soro do sangue com um sistema de separação do plasma e/ou do soro
US9283560B2 (en) 2013-11-22 2016-03-15 Sharp Kabushiki Kaisha Passive microfluidic metering device
US10670579B2 (en) * 2014-03-21 2020-06-02 Dbs System Sa Device and method for separating a fluid mixture such as blood
EP3154666B1 (en) * 2014-06-13 2020-12-09 GattaCo, Inc. Capillary pressure re-set mechanism and applications
WO2017015243A1 (en) * 2015-07-21 2017-01-26 Mcneely Michael Ryan Automatic plasma separation and metering
US10946378B2 (en) * 2015-09-04 2021-03-16 North Carolina State University Passive pumps for microfluidic devices
TWI637174B (zh) * 2017-08-15 2018-10-01 國立清華大學 過濾輔助微流道晶片模組，及過濾輔助微流道晶片的製作方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015044454A2 (en) * 2013-09-30 2015-04-02 Göran Stemme A microfluidic device, use and methods
WO2016209147A1 (en) * 2015-06-20 2016-12-29 Roxhed Niclas A plasma separating microfluidic device

Also Published As

Publication number Publication date
US12539513B2 (en) 2026-02-03
EP3847458A1 (en) 2021-07-14
EP3847458A4 (en) 2022-06-15
JP7409693B2 (ja) 2024-01-09
JP2022504018A (ja) 2022-01-13
WO2020050770A1 (en) 2020-03-12
US20210316300A1 (en) 2021-10-14
CN113167785A (zh) 2021-07-23

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