CN113167771B - 具有多个液相色谱仪的分析装置及其分析方法 - Google Patents

具有多个液相色谱仪的分析装置及其分析方法 Download PDF

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Publication number
CN113167771B
CN113167771B CN201980076368.7A CN201980076368A CN113167771B CN 113167771 B CN113167771 B CN 113167771B CN 201980076368 A CN201980076368 A CN 201980076368A CN 113167771 B CN113167771 B CN 113167771B
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sample
detector
liquid chromatographs
allowable range
peak separation
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CN113167771A (zh
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秋枝大介
野上真
铃木岩
河原井雅子
绪方泉
伊藤伸也
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Hitachi High Tech Corp
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Hitachi High Technologies Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N2030/628—Multiplexing, i.e. several columns sharing a single detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/24—Automatic injection systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
CN201980076368.7A 2018-11-20 2019-11-19 具有多个液相色谱仪的分析装置及其分析方法 Active CN113167771B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018-217157 2018-11-20
JP2018217157 2018-11-20
PCT/JP2019/045240 WO2020105624A1 (ja) 2018-11-20 2019-11-19 複数の液体クロマトグラフを有する分析装置およびその分析方法

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CN113167771A CN113167771A (zh) 2021-07-23
CN113167771B true CN113167771B (zh) 2023-09-29

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US (1) US11982655B2 (enExample)
EP (1) EP3885763A4 (enExample)
JP (1) JP7282801B2 (enExample)
CN (1) CN113167771B (enExample)
WO (1) WO2020105624A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230012349A1 (en) * 2019-12-13 2023-01-12 Spira Innovation Inc. Anomaly detection and diagnosis in chromatography applications

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2593212B (en) * 2020-03-20 2022-10-05 Agilent Technologies Inc Sample separation network with simply connectable sample separation device
ES3015159T3 (en) 2020-10-28 2025-04-29 Hoffmann La Roche Liquid chromatography - stream equivalence by single stream calibration
CN112485356B (zh) * 2020-12-08 2025-01-21 悟空科学仪器(上海)有限公司 用于高效液相色谱仪的预载样进样器、高效液相色谱仪及其预载样控制方法
CN117929610A (zh) * 2023-06-16 2024-04-26 常州三泰科技有限公司 一种液相色谱仪系统控制方法及装置

Citations (8)

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JP2003161725A (ja) * 2002-10-10 2003-06-06 Hitachi Ltd クロマトグラム解析方法
JP2008224559A (ja) * 2007-03-15 2008-09-25 Hitachi High-Technologies Corp 液体クロマトグラフ装置
CN101855548A (zh) * 2007-11-12 2010-10-06 安捷伦科技有限公司 具有可变流速的hplc系统
CN103675172A (zh) * 2012-08-31 2014-03-26 株式会社堀场Stec 气相色谱仪用数据处理装置、数据处理方法
JP2015141141A (ja) * 2014-01-30 2015-08-03 株式会社日立ハイテクノロジーズ 液体クロマトグラフ装置
JP2017138248A (ja) * 2016-02-05 2017-08-10 株式会社島津製作所 液体クロマトグラフ装置
CN107490632A (zh) * 2016-06-10 2017-12-19 日本株式会社日立高新技术科学 液相色谱仪以及液相色谱仪的检测器输出值变动校正方法
CN108604525A (zh) * 2015-12-01 2018-09-28 Dh科技发展私人贸易有限公司 用于靶向ms方法中的自适应保留时间的前哨信号

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JP3391862B2 (ja) 1993-10-05 2003-03-31 株式会社日立製作所 クロマトグラム解析方法
EP0835446B1 (en) * 1995-06-26 2003-04-09 Perseptive Biosystems, Inc. High speed, automated, continuous flow, multi-dimensional molecular selection and analysis
US6456955B1 (en) * 2000-12-05 2002-09-24 Waters Investments Limited Automated test protocol
US6635173B2 (en) * 2000-12-28 2003-10-21 Cohesive Technologies, Inc. Multi column chromatography system
US7645984B2 (en) * 2004-02-13 2010-01-12 Waters Technologies Corporation Apparatus and method for identifying peaks in liquid chromatography/mass spectrometry data and for forming spectra and chromatograms
JP2006084308A (ja) * 2004-09-15 2006-03-30 Shimadzu Corp 分析装置および分析システム
US9442098B2 (en) 2012-08-02 2016-09-13 Waters Technologies Corporation Chromatographic system quality control reference materials
US9829470B2 (en) * 2013-06-17 2017-11-28 Waters Technologies Corporation Systems and methods of compensation for chromatography column volume variations
WO2017216934A1 (ja) * 2016-06-16 2017-12-21 株式会社日立ハイテクノロジーズ クロマトグラフ質量分析装置、及び制御方法

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003161725A (ja) * 2002-10-10 2003-06-06 Hitachi Ltd クロマトグラム解析方法
JP2008224559A (ja) * 2007-03-15 2008-09-25 Hitachi High-Technologies Corp 液体クロマトグラフ装置
CN101855548A (zh) * 2007-11-12 2010-10-06 安捷伦科技有限公司 具有可变流速的hplc系统
CN103675172A (zh) * 2012-08-31 2014-03-26 株式会社堀场Stec 气相色谱仪用数据处理装置、数据处理方法
JP2015141141A (ja) * 2014-01-30 2015-08-03 株式会社日立ハイテクノロジーズ 液体クロマトグラフ装置
CN108604525A (zh) * 2015-12-01 2018-09-28 Dh科技发展私人贸易有限公司 用于靶向ms方法中的自适应保留时间的前哨信号
JP2017138248A (ja) * 2016-02-05 2017-08-10 株式会社島津製作所 液体クロマトグラフ装置
CN107490632A (zh) * 2016-06-10 2017-12-19 日本株式会社日立高新技术科学 液相色谱仪以及液相色谱仪的检测器输出值变动校正方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230012349A1 (en) * 2019-12-13 2023-01-12 Spira Innovation Inc. Anomaly detection and diagnosis in chromatography applications
US12416608B2 (en) * 2019-12-13 2025-09-16 Spira Innovation Inc. Anomaly detection and diagnosis in chromatography applications

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US20210389287A1 (en) 2021-12-16
JP7282801B2 (ja) 2023-05-29
EP3885763A1 (en) 2021-09-29
WO2020105624A1 (ja) 2020-05-28
EP3885763A4 (en) 2022-07-27
CN113167771A (zh) 2021-07-23
JPWO2020105624A1 (ja) 2021-10-07
US11982655B2 (en) 2024-05-14

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