CN113166721A - 抑郁症治疗方法和药物 - Google Patents

抑郁症治疗方法和药物 Download PDF

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Publication number
CN113166721A
CN113166721A CN201980076664.7A CN201980076664A CN113166721A CN 113166721 A CN113166721 A CN 113166721A CN 201980076664 A CN201980076664 A CN 201980076664A CN 113166721 A CN113166721 A CN 113166721A
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CN
China
Prior art keywords
polypeptide
depression
glur2
subject
administration
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Pending
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CN201980076664.7A
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English (en)
Inventor
王玉田
李扬
郭飞
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Qingdao Primedicine Pharmaceutical Co ltd
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Qingdao Primedicine Pharmaceutical Co ltd
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Publication of CN113166721A publication Critical patent/CN113166721A/zh
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1787Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

一种抑郁症治疗方法和药物。具体而言,一种GluR2‑CT多肽在治疗抑郁症,特别是重度抑郁症的用途。

Description

PCT国内申请,说明书已公开。

Claims (9)

  1. PCT国内申请,权利要求书已公开。
CN201980076664.7A 2018-11-21 2019-11-21 抑郁症治疗方法和药物 Pending CN113166721A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201811390067 2018-11-21
CN2018113900675 2018-11-21
PCT/CN2019/119855 WO2020103889A1 (zh) 2018-11-21 2019-11-21 抑郁症治疗方法和药物

Publications (1)

Publication Number Publication Date
CN113166721A true CN113166721A (zh) 2021-07-23

Family

ID=70774338

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980076664.7A Pending CN113166721A (zh) 2018-11-21 2019-11-21 抑郁症治疗方法和药物

Country Status (3)

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US (1) US20220347266A1 (zh)
CN (1) CN113166721A (zh)
WO (1) WO2020103889A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO135590A1 (ro) * 2020-08-31 2022-03-30 Szedlacsek Ştefan Eugen Peptide de interferenţă ca inhibitori ai interacţiunilor legate de endocitoza receptorilor ampa

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101961325A (zh) * 2010-10-29 2011-02-02 西南交通大学 大黄素在制备治疗抑郁症药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030051266A1 (en) * 2001-02-14 2003-03-13 Serafini Tito Andrew Collections of transgenic animal lines (living library)
WO2010083338A2 (en) * 2009-01-14 2010-07-22 Philadelphia Health And Education Corporation Modulation of pre-mrna using splice modulating oligonucleotides as therapeutic agents in the treatment of disease
CN106632601B (zh) * 2016-11-16 2020-10-20 中国科学院昆明动物研究所 一种阻断突触长时程增强(ltp)的短肽及其应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101961325A (zh) * 2010-10-29 2011-02-02 西南交通大学 大黄素在制备治疗抑郁症药物中的应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YANZHI YU ET AL.: "Facilitated AMPAR endocytosis causally contributes to the maternal sleep deprivation-induced impairments of synaptic plasticity and cognition in the offspring rats", 《NEUROPHARMACOLOGY》 *

Also Published As

Publication number Publication date
WO2020103889A1 (zh) 2020-05-28
US20220347266A1 (en) 2022-11-03

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