CN113164607A - Rig-i激动剂及其使用方法 - Google Patents

Rig-i激动剂及其使用方法 Download PDF

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Publication number
CN113164607A
CN113164607A CN201980079077.3A CN201980079077A CN113164607A CN 113164607 A CN113164607 A CN 113164607A CN 201980079077 A CN201980079077 A CN 201980079077A CN 113164607 A CN113164607 A CN 113164607A
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molecule
rna
nucleic acid
cancer
group
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CN201980079077.3A
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Chinese (zh)
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A·M·派尔
O·费多罗瓦
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Yale University
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Yale University
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3183—Diol linkers, e.g. glycols or propanediols
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands

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  • Physics & Mathematics (AREA)
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  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
CN201980079077.3A 2018-10-09 2019-10-09 Rig-i激动剂及其使用方法 Pending CN113164607A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862743387P 2018-10-09 2018-10-09
US62/743,387 2018-10-09
PCT/US2019/055394 WO2020076948A1 (en) 2018-10-09 2019-10-09 Rig-i agonists and methods of using same

Publications (1)

Publication Number Publication Date
CN113164607A true CN113164607A (zh) 2021-07-23

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980079077.3A Pending CN113164607A (zh) 2018-10-09 2019-10-09 Rig-i激动剂及其使用方法

Country Status (6)

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US (2) US20210230596A1 (https=)
EP (1) EP3863675A4 (https=)
JP (1) JP2022512651A (https=)
CN (1) CN113164607A (https=)
CA (1) CA3115294A1 (https=)
WO (1) WO2020076948A1 (https=)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160046943A1 (en) * 2013-03-13 2016-02-18 Yale University Interferon Production Using Short RNA Duplexes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9181551B2 (en) * 2002-02-20 2015-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
AU2003256857A1 (en) * 2002-08-08 2004-02-25 Dharmacon, Inc. Short interfering rnas having a hairpin structure containing a non-nucleotide loop
EP3342415B1 (en) * 2006-08-08 2022-01-26 Rheinische Friedrich-Wilhelms-Universität Bonn Structure and use of 5' phosphate oligonucleotides
WO2013077446A1 (ja) * 2011-11-26 2013-05-30 株式会社ボナック 遺伝子発現制御のための一本鎖核酸分子
WO2019204743A1 (en) * 2018-04-19 2019-10-24 Checkmate Pharmaceuticals, Inc. Synthetic rig-i-like receptor agonists
CA3110102A1 (en) * 2018-06-20 2019-12-26 Yale University Rig-i agonists and treatments using same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160046943A1 (en) * 2013-03-13 2016-02-18 Yale University Interferon Production Using Short RNA Duplexes

Also Published As

Publication number Publication date
JP2022512651A (ja) 2022-02-07
EP3863675A1 (en) 2021-08-18
CA3115294A1 (en) 2020-04-16
US20230159923A1 (en) 2023-05-25
EP3863675A4 (en) 2023-09-06
WO2020076948A1 (en) 2020-04-16
US20210230596A1 (en) 2021-07-29

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