CN113144280A - 智能抗菌水凝胶及其应用 - Google Patents

智能抗菌水凝胶及其应用 Download PDF

Info

Publication number
CN113144280A
CN113144280A CN202110349023.3A CN202110349023A CN113144280A CN 113144280 A CN113144280 A CN 113144280A CN 202110349023 A CN202110349023 A CN 202110349023A CN 113144280 A CN113144280 A CN 113144280A
Authority
CN
China
Prior art keywords
hydrogel
intelligent
antibacterial
antibacterial hydrogel
intelligent antibacterial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN202110349023.3A
Other languages
English (en)
Other versions
CN113144280B (zh
Inventor
肖健
李鹏
孔晓霞
厦卫东
张汉波
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cixi Institute Of Biomedicine Wenzhou Medical University
Original Assignee
Cixi Institute Of Biomedicine Wenzhou Medical University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cixi Institute Of Biomedicine Wenzhou Medical University filed Critical Cixi Institute Of Biomedicine Wenzhou Medical University
Priority to CN202110349023.3A priority Critical patent/CN113144280B/zh
Publication of CN113144280A publication Critical patent/CN113144280A/zh
Application granted granted Critical
Publication of CN113144280B publication Critical patent/CN113144280B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/12—Agar-agar; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2333/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers
    • C08J2333/02—Homopolymers or copolymers of acids; Metal or ammonium salts thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2405/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2401/00 or C08J2403/00
    • C08J2405/12—Agar-agar; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2405/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2401/00 or C08J2403/00
    • C08J2405/16—Cyclodextrin; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

本发明涉及一种智能抗菌水凝胶及其应用，所述智能抗菌水凝胶包括抗菌活性成分、1.5～2.5wt％环糊精、3～5wt％聚丙烯酸、3～5wt％琼脂、适量pH调节剂和余量的去离子水。本发明的智能抗菌水凝胶具有温度敏感性，能够依据创伤部位的温度变化自动调整抗菌成分的释放速率。本发明的智能抗菌水凝胶用途广泛，可用作促进急慢性创伤(特别是烧伤、大面积慢性创面)的皮肤创伤修复敷料，在皮肤原位再生修复及体外皮肤组织工程构建领域也有应用价值。

Description

智能抗菌水凝胶及其应用
技术领域
本发明属于生物医用材料领域，具体涉及一种用于皮肤浅表损伤快速修复的智能抗菌水凝胶及其应用。
背景技术
多年来，日常生活中突发性事故的急救治疗、医生对病人手术过程中的创伤止血、战争中受伤战士的救护止血手段大都是通过物理的压迫，如使用绷带、纱布、橡胶条等，但效果有限。在临床医学，在救治阶梯全链条的包扎止血需求，尤其是对于突发事件中的创面急性剧烈出血，由于突发出血环境的湿态多样性和动态复杂性，目前市售止血产品均不能达到快速有效止血同时可以抗菌的作用，极易发生失血性休克危及生命。目前市场上的止血材料主要包括“胶原蛋白类、氧化再生纤维素类、藻酸盐类、沸石类和壳聚糖类”等。
目前，在创伤的护理过程中，医用敷料已经获得了大面积的应用，具有可以有效的隔离伤口、隔离病原体、促进伤口愈合的效果。并且医用敷料的使用简单，粘贴于伤口上即可目前商用医用粘合剂一般通过喷涂、按压等方式封闭伤口达到止血目的，不具备内源性止血的功能，都存在诸多不足。沸石适用范围受限，不易用于伤口朝下的部位，而且血流冲走颗粒导致止血效果降低。更严重的是，沸石在吸收水分时，会放出大量的热，最高温度可达到44℃，导致受伤组织出现较为严重的热损伤和灼伤；纤维蛋白粘合剂，其存在价格昂贵、制备时间长、携带病毒感染等风险，如在腹腔内使用极易导致严重的组织粘连，难以清除，副作用大等；α-氰基丙烯酸酯类组织胶对粘合组织的表面要求较高，伤口表面需要保持干燥、洁净且不存在血液/消化液等，使得其实际应用中存在有极大约束，如操作繁琐、耗时长等。同时，市售止血材料降解时会释放甲醛和氰等有毒物质，无法与抗生素软膏或凡士林纱布同时使用。否则会在机体组织内引起炎症反应，甚至延缓伤口愈合。浸入高岭土的非针织纱布，其存在不具生物可降解性，必须在手术前从伤口移除等问题。
水凝胶是一种具有三维结构的高分子聚合物网络，能在水中溶胀并保持大量水分而又不溶解。水凝胶具有良好的生物相容性，在药物释放系统、仿生材料、酶的固定化、组织工程等领域有着广阔的应用前景。尤其是环境敏感性水凝胶，能够对外界环境中诸如物理或化学的微小变化做出响应，产生相应的结构或理化性质方面的变化。其中因为温度的改变不仅容易控制而且体内外都适用，温敏性水凝胶受到了广泛研究。材料的热力学可逆性使材料在常温下流动性增强，利于注射，而皮肤温度使材料固化，其定型性和可塑性增强。因此温敏性可注射的水凝胶材料的应用具有显著的优势。目前尽管有不同种类的温敏可注射水凝胶被开发，比如嵌段聚合物PEO-PPO-PEO,又称Pluronics，但存在所需固含量较高，力学强度以及稳定性欠佳等问题。
中国专利CN108484797B公开了一种温度敏感水凝胶，由上述的烷氧醚树枝化壳聚糖构筑，其特征在于使用不同接枝率的烷氧醚树枝化壳聚糖，通过不同的成胶方式，皆可获得水凝胶，该水凝胶表观上为透明状，具有良好的力学性能，通过改变温度，在25℃-60℃范围内加热，凝胶的力学性能会有所增强，同时其体积有所收缩。
中国专利申请CN106310347A公开了一种温度敏感型皮肤创伤敷料及其制备方法和应用，其中所述温度敏感型复合水凝胶中的组分及质量分数如下：海藻酸盐：0.5～2％；琼脂和/或琼脂糖：0.5～2％；水：剩余部分。该温度敏感型皮肤创伤敷料的组分中的琼脂和/或琼脂糖可以用于调节敷料的温度敏感特性，具体表现在溶解温度及在体温附近形成稳定水凝胶所需的时间。组分中的海藻酸盐可以用于调节本发明的力学性能，有利于适应不同创伤部位的需求。
虽然现有技术已经有不同的温度敏感性凝胶伤口敷料，但上述温度敏感性凝胶主要是指在体温附近形成凝胶。本领域仍需要研发出一种智能抗菌水凝胶，通过精确调整组分含量，使其在正常体温时缓慢释放抗菌活性成分，而在伤口温度升高(例如超过37.5℃)的情况下，快速释放抗菌活性成分。
发明内容
基于上述背景技术，本发明所要解决的技术问题在于提供一种智能抗菌水凝胶，通过精确调整组分含量，使其在正常体温时缓慢释放抗菌活性成分，而在伤口温度升高(例如超过 37.5℃)的情况下，快速释放抗菌活性成分。为了实现本发明的发明目的，拟采用如下技术方案：
本发明一方面涉及一种智能抗菌水凝胶，其包括抗菌活性成分、1.5～2.5wt％环糊精、 3～5wt％聚丙烯酸、3～5wt％琼脂、适量pH调节剂和余量的去离子水。
在本发明的一个优选实施方式中，所述智能抗菌水凝胶为薄膜。本发明通过将水凝胶设置为薄膜形态，可以直接用于创伤部位的敷料。
在本发明的一个优选实施方式中，所述智能抗菌水凝胶的pH为6.5～7.5。
在本发明的一个优选实施方式中，所述抗菌活性成分为莫匹罗星，所述莫匹罗星的量为 1.5～2.5wt％。
在本发明的一个优选实施方式中，所述智能抗菌水凝胶在37.5℃时抗菌活性成分的释放率显著变化。
本发明另一方面还涉及上述智能抗菌水凝胶的制备方法，其制备步骤如下：
1、在配制罐中加入配制总量40～60％的去离子水，加入环糊精，搅拌均匀之后加入莫匹罗星，搅拌10～20min；
2、将聚丙烯酸溶解于剩余的去离子水中，加入琼脂，加热到45～60℃，搅拌15～20min 后；
3、将步骤1与步骤2所得的分散体混合，在45～60℃条件下搅拌均匀，调节pH，将其置于底面为平面的容器中，室温下冷却得到凝胶薄膜。
本发明另一方还涉及上述智能抗菌水凝胶的应用，其应用于皮肤浅表损伤的快速修复。
有益效果
本发明的智能抗菌水凝胶具有温度敏感性，能够依据创伤部位的温度变化自动调整抗菌成分的释放速率。本发明的智能抗菌水凝胶用途广泛，可用作促进急慢性创伤(特别是烧伤、大面积慢性创面)的皮肤创伤修复敷料，在皮肤原位再生修复及体外皮肤组织工程构建领域也有应用价值。
附图说明
图1为示出本发明的凝胶薄膜在37.5℃左右具有温度敏感性的图。
具体实施方式
为了进一步理解本发明，下面将结合本发明实施例，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
如无特殊说明，本发明实施例中所涉及的试剂均为市售产品，均可以通过商业渠道购买获得。
实施例1：一种智能抗菌水凝胶的制备方法，其配方如下：
莫匹罗星 1g
环糊精 1g
聚丙烯酸 2g
琼脂 2g
pH调节剂适量
去离子水 50g
其制备步骤如下：
1、在配制罐中加入配制总量一半的去离子水，加入环糊精，搅拌均匀之后加入莫匹罗星，搅拌10～20min；
2、将聚丙烯酸溶解于剩余的去离子水中，加入琼脂，加热到50℃，搅拌15～20min后；
3、将步骤1与步骤2所得的分散体混合，在50℃条件下搅拌均匀，调节pH至7.0，将其置于培养皿中，室温下冷却得到厚度为1mm的凝胶薄膜。
实施例2：
与实施例1相同，区别在于聚丙烯酸的用量为2.5g。
对比例1：
与实施例1相同，区别在于琼脂的用量为1g。
对比例2：
与实施例1相同，区别在于环糊精的用量为0.5g。
对比例3：
与实施例1相同，区别在于将所述聚丙烯酸的用量为0.5g。
实施例3：释放实验
分别取所制备的凝胶薄膜2cm×2cm，将其置于4mLpH为7.4的PBS缓冲溶液中，PBS溶液完全浸没凝胶薄膜。分别控制PBS的温度，在浸没1小时之后测定PBS缓冲溶液中莫匹罗星的浓度并推算从凝胶薄膜中释放的莫匹罗星的量。基于凝胶薄膜中原始的莫匹罗星的量和释放的莫匹罗星的量，确定凝胶薄膜在不同温度下1小时的释放量。
实验结果参见图1，从图1可以看出，实施例1和实施例2的凝胶薄膜在37.5℃时，释放率有明显变化，由此说明实施例的凝胶薄膜在37.5℃左右具有温度敏感性。与实施例不同，比较例1-3，其释放率随温度变化的趋势不明显，特别是实施例3而言，由于聚丙烯酸的含量较低，虽然其释放率较高，但是其缺乏温度敏感性。
以上描述了本发明优选实施方式，然其并非用以限定本发明。本领域技术人员对在此公开的实施方案可进行并不偏离本发明范畴和精神的改进和变化。

Claims (7)

1.一种智能抗菌水凝胶，其包括抗菌活性成分、1.5～2.5wt％环糊精、3～5wt％聚丙烯酸、3～5wt％琼脂、适量pH调节剂和余量的去离子水。
2.根据权利要求1所述的智能抗菌水凝胶，所述智能抗菌水凝胶为薄膜。
3.根据权利要求1所述的智能抗菌水凝胶，所述智能抗菌水凝胶的pH为6.5～7.5。
4.根据权利要求1所述的智能抗菌水凝胶，所述抗菌活性成分为莫匹罗星，所述莫匹罗星的量为1.5～2.5wt％。
5.根据权利要求1所述的智能抗菌水凝胶，所述智能抗菌水凝胶在37.5℃时抗菌活性成分的释放率显著变化。
6.权利要求1-5任意一项所述智能抗菌水凝胶的制备方法，其制备步骤如下：
(1)在配制罐中加入配制总量40～60％的去离子水，加入环糊精，搅拌均匀之后加入莫匹罗星，搅拌10～20min；
(2)将聚丙烯酸溶解于剩余的去离子水中，加入琼脂，加热到45～60℃，搅拌15～20min后；
(3)将步骤1与步骤2所得的分散体混合，在45～60℃条件下搅拌均匀，调节pH，将其置于底面为平面的容器中，室温下冷却得到凝胶薄膜。
7.权利要求1-5任意一项所述智能抗菌水凝胶的应用，其应用于皮肤浅表损伤的快速修复。
CN202110349023.3A 2021-03-31 2021-03-31 智能抗菌水凝胶及其应用 Active CN113144280B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110349023.3A CN113144280B (zh) 2021-03-31 2021-03-31 智能抗菌水凝胶及其应用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202110349023.3A CN113144280B (zh) 2021-03-31 2021-03-31 智能抗菌水凝胶及其应用

Publications (2)

Publication Number Publication Date
CN113144280A true CN113144280A (zh) 2021-07-23
CN113144280B CN113144280B (zh) 2022-08-16

Family

ID=76885732

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202110349023.3A Active CN113144280B (zh) 2021-03-31 2021-03-31 智能抗菌水凝胶及其应用

Country Status (1)

Country Link
CN (1) CN113144280B (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113730648A (zh) * 2021-09-06 2021-12-03 温州瑞司特生物科技有限公司 结合表皮葡萄球菌的水凝胶及其在治疗创面中的应用
CN113730378A (zh) * 2021-09-06 2021-12-03 温州瑞司特生物科技有限公司 用于治疗创面的反蛋白石水凝胶微载体及其应用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050031547A1 (en) * 2003-08-04 2005-02-10 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
CN104353105A (zh) * 2014-11-10 2015-02-18 苏州蔻美新材料有限公司 一种医用纳米抗菌凝胶材料及其制备方法
CN106310347A (zh) * 2015-06-30 2017-01-11 中国科学院上海硅酸盐研究所 一种温度敏感型皮肤创伤敷料及其制备方法和应用
CN109395142A (zh) * 2019-01-07 2019-03-01 温州医科大学 一种吸湿透气型抑菌伤口敷料
US20190314555A1 (en) * 2018-04-11 2019-10-17 University Of Vermont And State Agricultural College Supramolecular Alginate Materials for Biomedical Applications
CN110585117A (zh) * 2019-09-16 2019-12-20 五邑大学 一种根皮素的温敏性凝胶制剂及其制备方法和应用
CN110743035A (zh) * 2019-11-06 2020-02-04 广西大学 一种智能抗菌的水凝胶的制备方法及其应用
US20210087337A1 (en) * 2016-08-31 2021-03-25 Vyome Therapeutics Limited Compounds, compositions and methods related to antimicrobial applications

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050031547A1 (en) * 2003-08-04 2005-02-10 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
CN104353105A (zh) * 2014-11-10 2015-02-18 苏州蔻美新材料有限公司 一种医用纳米抗菌凝胶材料及其制备方法
CN106310347A (zh) * 2015-06-30 2017-01-11 中国科学院上海硅酸盐研究所 一种温度敏感型皮肤创伤敷料及其制备方法和应用
US20210087337A1 (en) * 2016-08-31 2021-03-25 Vyome Therapeutics Limited Compounds, compositions and methods related to antimicrobial applications
US20190314555A1 (en) * 2018-04-11 2019-10-17 University Of Vermont And State Agricultural College Supramolecular Alginate Materials for Biomedical Applications
CN109395142A (zh) * 2019-01-07 2019-03-01 温州医科大学 一种吸湿透气型抑菌伤口敷料
CN110585117A (zh) * 2019-09-16 2019-12-20 五邑大学 一种根皮素的温敏性凝胶制剂及其制备方法和应用
CN110743035A (zh) * 2019-11-06 2020-02-04 广西大学 一种智能抗菌的水凝胶的制备方法及其应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
QING YAO等: "Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing", 《THERANOSTICS》 *
徐浩主编: "《药用辅料质量管理规范与现代辅料新技术应用全书 1》", 28 February 2005, 天津电子出版社 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113730648A (zh) * 2021-09-06 2021-12-03 温州瑞司特生物科技有限公司 结合表皮葡萄球菌的水凝胶及其在治疗创面中的应用
CN113730378A (zh) * 2021-09-06 2021-12-03 温州瑞司特生物科技有限公司 用于治疗创面的反蛋白石水凝胶微载体及其应用
CN113730378B (zh) * 2021-09-06 2024-05-14 温州瑞司特生物科技有限公司 用于治疗创面的反蛋白石水凝胶微载体及其应用

Also Published As

Publication number Publication date
CN113144280B (zh) 2022-08-16

Similar Documents

Publication Publication Date Title
Pogorielov et al. Chitosan as a hemostatic agent: current state
EP3659631B1 (en) Wound dressing comprising hyaluronic acid-calcium and polylysine and manufacturing method therefor
US8475812B2 (en) Gelatin sponge comprising an active ingredient, its preparation and use
EP2233157A1 (en) A biocompatible denatured starch sponge material
CN109106974B (zh) 凝胶组织封堵材料及其制备方法和封堵制品
US20030148994A1 (en) Hemostatic composition
US20140010887A1 (en) Modified starch material of biocompatible hemostasis
KR101649792B1 (ko) 비압박 지혈용 고분자 폼 제조용 조성물, 이를 이용한 비압박 지혈용 고분자 폼의 제조방법 및 비압박 지혈 팩킹용 고분자 폼
WO2009091549A1 (en) Modified starch material of biocompatible hemostasis
CN113144280B (zh) 智能抗菌水凝胶及其应用
CN104857552B (zh) 一种止血贴及其制备方法
WO2004002460A1 (en) Infused wound care dressings
AU2005221699A1 (en) Compositions of alpha and beta chitosan and methods of preparing them
EP3308807B1 (en) Porous structure and method for manufacturing same
Zhu et al. Polysaccharides composite materials for rapid hemostasis
Mercy et al. Chitosan-derivatives as hemostatic agents: Their role in tissue regeneration
Li et al. An injectable collagen peptide-based hydrogel with desirable antibacterial, self-healing and wound-healing properties based on multiple-dynamic crosslinking
Zhang et al. Recent advances of chitosan as a hemostatic material: Hemostatic mechanism, material design and prospective application
CN113908330B (zh) 一种具有光热抗菌止血特性的复合凝胶的制备方法及其产品和应用
US11357883B1 (en) Method for preparing absorbable haemostatic composition for body and haemostatic composition prepared thereby
CN113663120B (zh) 止血海绵垫芯及其制备方法
KR20030060458A (ko) 상처 치료용 수화겔의 제조방법
CN111905144B (zh) 一种可生物降解的晶胶敷料及其制备方法和应用
Xu et al. Hierarchically cross-linked Gelatin/Tannic acid/Laponite hybrid antimicrobial hydrogel for hemostatic dressings
CN112300418A (zh) 一种可粘附高效止血微球及其制备方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CB03 Change of inventor or designer information
CB03 Change of inventor or designer information

Inventor after: Xiao Jian

Inventor after: Li Peng

Inventor after: Kong Xiaoxia

Inventor after: Xia Weidong

Inventor after: Zhang Hanbo

Inventor before: Xiao Jian

Inventor before: Li Peng

Inventor before: Kong Xiaoxia

Inventor before: Xia Weidong

Inventor before: Zhang Hanbo