CN113144034A - Traditional Chinese medicine composition with effect of preventing and treating hand-foot syndrome and preparation method thereof - Google Patents
Traditional Chinese medicine composition with effect of preventing and treating hand-foot syndrome and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a traditional Chinese medicine composition with a function of preventing and treating hand-foot syndrome and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 10-50 parts of raw astragalus membranaceus, 15-40 parts of lithospermum, 8-25 parts of raw rhubarb, 20-38 parts of dandelion, 22-42 parts of paniculate swallowwort root, 15-35 parts of honey-fried licorice root, 10-35 parts of angelica sinensis, 12-25 parts of golden cypress, 13-23 parts of dittany bark, 28-36 parts of angelica dahurica, 14-26 parts of fructus kochiae and 20-33 parts of fried white paeony root. The pharmaceutical composition can effectively improve the hand-foot syndrome, can safely and effectively relieve or even cure the hand-foot syndrome diseases, has small side effect, has higher safety compared with western medicines, can fundamentally improve the characteristic of recurrent attacks of the hand-foot syndrome, and has simple preparation method and easy mass production.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition with a function of preventing and treating hand-foot syndrome and a preparation method thereof.
Background
Hand-foot syndrome is a skin toxic reaction which occurs mainly in the course of chemotherapy or molecular targeted therapy of tumor patients and is characterized by numbness, dysesthesia, paresthesia, tingling, no pain or pain, skin swelling or erythema, desquamation, chapping, induration-like blisters or severe pain, etc. In the prior art, a treatment method with a definite curative effect is not available, and Western medicine recommends that vitamin external vaseline ointment or skin care lotion is taken orally, so that the effect is poor, the repeated attack is caused, and the side effect is great. In addition, palmar-plantar erythrodysesthesia can only be alleviated or cured by reducing or disabling chemotherapy or molecularly targeted drugs.
The traditional Chinese medicine has certain advantages for preventing and treating the hand-foot syndrome, and the existing Chinese patent medicines for treating the hand-foot syndrome, particularly the Chinese patent medicines for treating the hand-foot syndrome, have a large blank. Therefore, the development of a Chinese patent medicine for treating hand-foot syndrome has great significance for treating hand-foot syndrome.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provides a traditional Chinese medicine composition with the effect of preventing and treating hand-foot syndrome.
In order to achieve the purpose, the invention is realized by the following technical scheme:
a traditional Chinese medicine composition with an effect of preventing and treating hand-foot syndrome comprises the following components in parts by weight: 10-50 parts of raw astragalus membranaceus, 15-40 parts of lithospermum, 8-25 parts of raw rhubarb, 20-38 parts of dandelion, 22-42 parts of paniculate swallowwort root, 15-35 parts of honey-fried licorice root, 10-35 parts of angelica sinensis, 12-25 parts of golden cypress, 13-23 parts of dittany bark, 28-36 parts of angelica dahurica, 14-26 parts of fructus kochiae and 20-33 parts of fried white paeony root.
Preferably, the traditional Chinese medicine composition with the effect of preventing and treating hand-foot syndrome comprises the following components in parts by weight: 40 parts of raw astragalus root, 25 parts of lithospermum, 15 parts of raw rhubarb, 30 parts of dandelion, 30 parts of paniculate swallowwort root, 20 parts of honey-fried licorice root, 25 parts of angelica, 20 parts of phellodendron, 20 parts of dittany bark, 30 parts of angelica dahurica, 20 parts of belvedere fruit and 25 parts of fried white paeony root.
Preferably, the traditional Chinese medicine composition with the effect of preventing and treating hand-foot syndrome comprises the following components in parts by weight: 10 parts of raw astragalus membranaceus, 15 parts of lithospermum, 8 parts of raw rhubarb, 20 parts of dandelion, 22 parts of cynanchum paniculatum, 15 parts of honey-fried licorice root, 10 parts of angelica sinensis, 12 parts of phellodendron amurense, 13 parts of dittany bark, 28 parts of angelica dahurica, 14 parts of belvedere fruit and 20 parts of fried white paeony root.
Preferably, the traditional Chinese medicine composition with the effect of preventing and treating hand-foot syndrome comprises the following components in parts by weight: 50 parts of raw astragalus root, 40 parts of lithospermum, 25 parts of raw rhubarb, 38 parts of dandelion, 42 parts of paniculate swallowwort root, 35 parts of honey-fried licorice root, 35 parts of angelica, 25 parts of phellodendron, 23 parts of dittany bark, 36 parts of angelica dahurica, 26 parts of belvedere fruit and 33 parts of fried white paeony root.
Preferably, the traditional Chinese medicine composition with the effect of preventing and treating hand-foot syndrome comprises the following components in parts by weight: 11 parts of raw astragalus, 39 parts of lithospermum, 24 parts of raw rhubarb, 37 parts of dandelion, 40 parts of paniculate swallowwort root, 33 parts of honey-fried licorice root, 18 parts of angelica, 24 parts of phellodendron, 22 parts of dittany bark, 29 parts of angelica dahurica, 25 parts of belvedere fruit and 31 parts of fried white paeony root.
Preferably, the traditional Chinese medicine composition with the effect of preventing and treating hand-foot syndrome comprises the following components in parts by weight: 28 parts of raw astragalus, 22 parts of lithospermum, 16 parts of raw rhubarb, 33 parts of dandelion, 26 parts of paniculate swallowwort root, 19 parts of honey-fried licorice root, 27 parts of angelica, 16 parts of phellodendron, 20 parts of dittany bark, 29 parts of angelica dahurica, 17 parts of belvedere fruit and 24 parts of fried white paeony root.
Preferably, the preparation method of the traditional Chinese medicine composition with the effect of preventing and treating the hand-foot syndrome comprises the following steps:
weighing 10-50 parts of raw astragalus membranaceus, 15-40 parts of lithospermum, 8-25 parts of raw rhubarb, 20-38 parts of dandelion, 22-42 parts of paniculate swallowwort root, 15-35 parts of honey-fried licorice root, 10-35 parts of angelica, 12-25 parts of phellodendron, 13-23 parts of dittany bark, 28-36 parts of angelica dahurica, 14-26 parts of fructus kochiae and 20-33 parts of fried white paeony root according to parts by weight;
step two, uniformly mixing the raw materials by a stirrer to obtain a mixture;
step three, crushing the mixture by a crusher to obtain mixed powder;
putting the mixed powder into distilled water, heating to 100 ℃, decocting in boiling water for 40-60 min, and then cooling to obtain a cooling liquid;
step five, decocting the cooling liquid again, then decocting for two hours, then cooling to room temperature, and then filtering to obtain a filtrate;
and step six, sterilizing the filtrate, and then packaging to obtain the traditional Chinese medicine preparation.
The invention has the following beneficial effects: the pharmaceutical composition can effectively improve the hand-foot syndrome, can safely and effectively relieve or even cure the hand-foot syndrome diseases, has small side effect, has higher safety compared with western medicines, can fundamentally improve the characteristic of recurrent attacks of the hand-foot syndrome, and has simple preparation method and easy mass production.
Detailed Description
The technical solution of the present invention is further explained below:
example 1:
a traditional Chinese medicine composition with an effect of preventing and treating hand-foot syndrome comprises the following components in parts by weight: 10-50 parts of raw astragalus membranaceus, 15-40 parts of lithospermum, 8-25 parts of raw rhubarb, 20-38 parts of dandelion, 22-42 parts of paniculate swallowwort root, 15-35 parts of honey-fried licorice root, 10-35 parts of angelica sinensis, 12-25 parts of golden cypress, 13-23 parts of dittany bark, 28-36 parts of angelica dahurica, 14-26 parts of fructus kochiae and 20-33 parts of fried white paeony root.
A preparation method of a traditional Chinese medicine composition with the effect of preventing and treating hand-foot syndrome comprises the following steps: weighing 10-50 parts of raw astragalus membranaceus, 15-40 parts of lithospermum, 8-25 parts of raw rhubarb, 20-38 parts of dandelion, 22-42 parts of paniculate swallowwort root, 15-35 parts of honey-fried licorice root, 10-35 parts of angelica, 12-25 parts of phellodendron, 13-23 parts of dittany bark, 28-36 parts of angelica dahurica, 14-26 parts of fructus kochiae and 20-33 parts of fried white paeony root according to parts by weight;
step two, uniformly mixing the raw materials by a stirrer to obtain a mixture;
step three, crushing the mixture by a crusher to obtain mixed powder;
putting the mixed powder into distilled water, heating to 100 ℃, decocting in boiling water for 40-60 min, and then cooling to obtain a cooling liquid;
step five, decocting the cooling liquid again, then decocting for two hours, then cooling to room temperature, and then filtering to obtain a filtrate;
and step six, sterilizing the filtrate, and then packaging to obtain the traditional Chinese medicine preparation.
Example 2:
a traditional Chinese medicine composition with an effect of preventing and treating hand-foot syndrome comprises the following components in parts by weight: 40 parts of raw astragalus root, 25 parts of lithospermum, 15 parts of raw rhubarb, 30 parts of dandelion, 30 parts of paniculate swallowwort root, 20 parts of honey-fried licorice root, 25 parts of angelica, 20 parts of phellodendron, 20 parts of dittany bark, 30 parts of angelica dahurica, 20 parts of belvedere fruit and 25 parts of fried white paeony root.
A preparation method of a traditional Chinese medicine composition with the effect of preventing and treating hand-foot syndrome comprises the following steps: weighing 40 parts of raw astragalus membranaceus, 25 parts of lithospermum, 15 parts of raw rhubarb, 30 parts of dandelion, 30 parts of paniculate swallowwort root, 20 parts of honey-fried licorice root, 25 parts of angelica, 20 parts of golden cypress, 20 parts of dittany bark, 30 parts of angelica dahurica, 20 parts of belvedere fruit and 25 parts of fried white paeony root according to parts by weight;
step two, uniformly mixing the raw materials by a stirrer to obtain a mixture;
step three, crushing the mixture by a crusher to obtain mixed powder;
putting the mixed powder into distilled water, heating to 100 ℃, decocting in boiling water for 40-60 min, and then cooling to obtain a cooling liquid;
step five, decocting the cooling liquid again, then decocting for two hours, then cooling to room temperature, and then filtering to obtain a filtrate;
and step six, sterilizing the filtrate, and then packaging to obtain the traditional Chinese medicine preparation.
All cases of the invention are from patients who meet the small hand-foot syndrome in month 1 to 12 in 1988 in 1948, 100 cases are selected, wherein 45 cases of men and 55 cases of women have the smallest onset age of 33 years and the largest cases have the largest onset age of 73 years, and the average age is 40 years. On average, 10 groups were divided into 10 groups according to age and disease condition, and 10 cases were given to each group.
The treatment medicines and the taking dosage are as follows: the product is aged 41-60 years old, and is administered by fumigating and washing 100ml each time 2 times a day; the product is aged 60-73 years, and is administered by fumigating and washing 100ml 3 times per day; the product is aged 33-40 years old, and is administered by fumigating and washing 100ml each time 1 time per day.
After the medicine is taken for one week, 82% of patients have obvious effect, and 93% of patients are completely cured after the medicine is taken for two weeks, no obvious adverse reaction occurs to the patients in the treatment process, and no adverse reaction of the test medicine is observed.
Example 3:
a traditional Chinese medicine composition with an effect of preventing and treating hand-foot syndrome comprises the following components in parts by weight: 10 parts of raw astragalus membranaceus, 15 parts of lithospermum, 8 parts of raw rhubarb, 20 parts of dandelion, 22 parts of cynanchum paniculatum, 15 parts of honey-fried licorice root, 10 parts of angelica sinensis, 12 parts of phellodendron amurense, 13 parts of dittany bark, 28 parts of angelica dahurica, 14 parts of belvedere fruit and 20 parts of fried white paeony root.
A preparation method of a traditional Chinese medicine composition with the effect of preventing and treating hand-foot syndrome comprises the following steps: weighing 10 parts of raw astragalus membranaceus, 15 parts of lithospermum, 8 parts of raw rhubarb, 20 parts of dandelion, 22 parts of paniculate swallowwort root, 15 parts of honey-fried licorice root, 10 parts of angelica, 12 parts of golden cypress, 13 parts of dittany bark, 28 parts of angelica dahurica, 14 parts of belvedere fruit and 20 parts of fried white paeony root according to parts by weight;
step two, uniformly mixing the raw materials by a stirrer to obtain a mixture;
step three, crushing the mixture by a crusher to obtain mixed powder;
putting the mixed powder into distilled water, heating to 100 ℃, decocting in boiling water for 40-60 min, and then cooling to obtain a cooling liquid;
step five, decocting the cooling liquid again, then decocting for two hours, then cooling to room temperature, and then filtering to obtain a filtrate;
and step six, sterilizing the filtrate, and then packaging to obtain the traditional Chinese medicine preparation.
All cases of the invention were from patients who met with little hand-foot syndrome in month 1 to 12 of 1945, 200 of which were selected, 95 of men and 105 of women, 23 years old with the smallest age of onset and 76 years old with the largest age, and the average age was 40 years old. On average, 10 groups were divided into 10 groups according to age and disease condition, and 10 cases were given to each group.
The treatment medicines and the taking dosage are as follows: 60-76 years old, 2 times daily, 100ml for fumigation and washing; the product is aged 40-59 years old, and is administered by fumigating and washing 100ml 3 times per day; the product is aged 23-39 years, and is administered by fumigating and washing 100ml 1 time per day.
After the medicine is taken for one week, 79% of patients have obvious effect, 84% of patients are completely cured after the medicine is taken for two weeks, no obvious adverse reaction occurs to the patients in the treatment process, and no adverse reaction of the test medicine exists.
Example 4:
a traditional Chinese medicine composition with an effect of preventing and treating hand-foot syndrome comprises the following components in parts by weight: 50 parts of raw astragalus root, 40 parts of lithospermum, 25 parts of raw rhubarb, 38 parts of dandelion, 42 parts of paniculate swallowwort root, 35 parts of honey-fried licorice root, 35 parts of angelica, 25 parts of phellodendron, 23 parts of dittany bark, 36 parts of angelica dahurica, 26 parts of belvedere fruit and 33 parts of fried white paeony root.
A preparation method of a traditional Chinese medicine composition with the effect of preventing and treating hand-foot syndrome comprises the following steps: weighing 50 parts of raw astragalus membranaceus, 40 parts of lithospermum, 25 parts of raw rhubarb, 38 parts of dandelion, 42 parts of paniculate swallowwort root, 35 parts of honey-fried licorice root, 35 parts of angelica, 25 parts of golden cypress, 23 parts of dittany bark, 36 parts of angelica dahurica, 26 parts of belvedere fruit and 33 parts of fried white paeony root according to parts by weight;
step two, uniformly mixing the raw materials by a stirrer to obtain a mixture;
step three, crushing the mixture by a crusher to obtain mixed powder;
putting the mixed powder into distilled water, heating to 100 ℃, decocting in boiling water for 40-60 min, and then cooling to obtain a cooling liquid;
step five, decocting the cooling liquid again, then decocting for two hours, then cooling to room temperature, and then filtering to obtain a filtrate;
and step six, sterilizing the filtrate, and then packaging to obtain the traditional Chinese medicine preparation.
All cases of the invention were selected from patients who met with little hand-foot syndrome in month 1 to 12 of 1945, and 300 cases were selected, wherein 150 cases were male, 150 cases were female, the person with the smallest onset age was 23 years old, the person with the largest onset age was 76 years old, and the average age was 40 years old. On average, 10 groups were divided into 10 groups according to age and disease condition, and 10 cases were given to each group.
The treatment medicines and the taking dosage are as follows: 60-76 years old, 2 times daily, 100ml for fumigation and washing; the product is aged 40-59 years old, and is administered by fumigating and washing 100ml 3 times per day; the product is aged 23-39 years, and is administered by fumigating and washing 100ml 1 time per day.
After the medicine is taken for one week, 78% of patients have obvious effect, 83% of patients are completely cured after the medicine is taken for two weeks, no obvious adverse reaction occurs to the patients in the treatment process, and no adverse reaction of the test medicine is observed.
Example 5:
a traditional Chinese medicine composition with an effect of preventing and treating hand-foot syndrome comprises the following components in parts by weight: 11 parts of raw astragalus, 39 parts of lithospermum, 24 parts of raw rhubarb, 37 parts of dandelion, 40 parts of paniculate swallowwort root, 33 parts of honey-fried licorice root, 18 parts of angelica, 24 parts of phellodendron, 22 parts of dittany bark, 29 parts of angelica dahurica, 25 parts of belvedere fruit and 31 parts of fried white paeony root.
A preparation method of a traditional Chinese medicine composition with the effect of preventing and treating hand-foot syndrome comprises the following steps: weighing 11 parts of raw astragalus membranaceus, 39 parts of lithospermum, 24 parts of raw rhubarb, 37 parts of dandelion, 40 parts of paniculate swallowwort root, 33 parts of honey-fried licorice root, 18 parts of angelica, 24 parts of golden cypress, 22 parts of dittany bark, 29 parts of angelica dahurica, 25 parts of belvedere fruit and 31 parts of fried white paeony root according to parts by weight;
step two, uniformly mixing the raw materials by a stirrer to obtain a mixture;
step three, crushing the mixture by a crusher to obtain mixed powder;
putting the mixed powder into distilled water, heating to 100 ℃, decocting in boiling water for 40-60 min, and then cooling to obtain a cooling liquid;
step five, decocting the cooling liquid again, then decocting for two hours, then cooling to room temperature, and then filtering to obtain a filtrate;
and step six, sterilizing the filtrate, and then packaging to obtain the traditional Chinese medicine preparation.
All cases of the invention were selected from patients who met with little hand-foot syndrome in month 1 to 12 of 1949, and 300 cases were selected, wherein 150 cases were male, 150 cases were female, the person with the smallest onset age was 23 years old, the person with the largest onset age was 72 years old, and the average age was 40 years old. On average, 10 groups were divided into 10 groups according to age and disease condition, and 10 cases were given to each group.
The treatment medicines and the taking dosage are as follows: 55-72 years old, 2 times daily, 100ml for fumigation and washing; the product is aged 40-54 years old, and is administered by fumigating and washing 100ml 3 times per day; the product is aged 23-40 years old, and is administered by fumigating and washing 100ml each time 1 time per day.
After the medicine is taken for one week, 81% of patients have obvious effect, 88% of patients are completely cured after the medicine is taken for two weeks, no obvious adverse reaction occurs to the patients in the treatment process, and no adverse reaction of the test medicine exists.
Example 6:
a traditional Chinese medicine composition with an effect of preventing and treating hand-foot syndrome comprises the following components in parts by weight: 28 parts of raw astragalus, 22 parts of lithospermum, 16 parts of raw rhubarb, 33 parts of dandelion, 26 parts of paniculate swallowwort root, 19 parts of honey-fried licorice root, 27 parts of angelica, 16 parts of phellodendron, 20 parts of dittany bark, 29 parts of angelica dahurica, 17 parts of belvedere fruit and 24 parts of fried white paeony root.
A preparation method of a traditional Chinese medicine composition with the effect of preventing and treating hand-foot syndrome comprises the following steps: weighing 28 parts of raw astragalus membranaceus, 22 parts of lithospermum, 16 parts of raw rhubarb, 33 parts of dandelion, 26 parts of paniculate swallowwort root, 19 parts of honey-fried licorice root, 27 parts of angelica, 16 parts of golden cypress, 20 parts of dittany bark, 29 parts of angelica dahurica, 17 parts of belvedere fruit and 24 parts of fried white paeony root according to parts by weight;
step two, uniformly mixing the raw materials by a stirrer to obtain a mixture;
step three, crushing the mixture by a crusher to obtain mixed powder;
putting the mixed powder into distilled water, heating to 100 ℃, decocting in boiling water for 40-60 min, and then cooling to obtain a cooling liquid;
step five, decocting the cooling liquid again, then decocting for two hours, then cooling to room temperature, and then filtering to obtain a filtrate;
and step six, sterilizing the filtrate, and then packaging to obtain the traditional Chinese medicine preparation.
All cases of the invention are selected from 100 cases of patients who meet the small hand-foot syndrome in the period from 1 month to 12 months in 1958, wherein 45 cases of men and 55 cases of women have the smallest onset age of 33 years and the largest cases have the largest onset age of 63 years, and the average age is 40 years. On average, 10 groups were divided into 10 groups according to age and disease condition, and 10 cases were given to each group.
The treatment medicines and the taking dosage are as follows: the product is aged 41-50 years old, and is administered by fumigating and washing 100ml 2 times daily; 50-63 years old, 3 times daily, 100ml for fumigation and washing; the product is aged 33-40 years old, and is administered by fumigating and washing 100ml each time 1 time per day.
After taking for one week, 80% of patients have obvious effect, and 90% of patients are completely cured after taking for two weeks, no obvious adverse reaction occurs to the patients in the treatment process, and no adverse reaction of the test medicine exists.
The pharmaceutical composition can effectively improve the hand-foot syndrome, can safely and effectively relieve or even cure the hand-foot syndrome diseases, has small side effect, has higher safety compared with western medicines, can fundamentally improve the characteristic of recurrent attacks of the hand-foot syndrome, and has simple preparation method and easy mass production.
It should be noted that the above list is only one specific embodiment of the present invention. It is clear that the invention is not limited to the embodiments described above, but that many variations are possible, all of which can be derived or suggested directly from the disclosure of the invention by a person skilled in the art, and are considered to be within the scope of the invention.
Claims (7)
1. The traditional Chinese medicine composition with the effect of preventing and treating hand-foot syndrome is characterized by comprising the following components in parts by weight: 10-50 parts of raw astragalus membranaceus, 15-40 parts of lithospermum, 8-25 parts of raw rhubarb, 20-38 parts of dandelion, 22-42 parts of paniculate swallowwort root, 15-35 parts of honey-fried licorice root, 10-35 parts of angelica sinensis, 12-25 parts of golden cypress, 13-23 parts of dittany bark, 28-36 parts of angelica dahurica, 14-26 parts of fructus kochiae and 20-33 parts of fried white paeony root.
2. The traditional Chinese medicine composition with the effect of preventing and treating hand-foot syndrome according to claim 1, is characterized by comprising the following components in parts by weight: 40 parts of raw astragalus root, 25 parts of lithospermum, 15 parts of raw rhubarb, 30 parts of dandelion, 30 parts of paniculate swallowwort root, 20 parts of honey-fried licorice root, 25 parts of angelica, 20 parts of phellodendron, 20 parts of dittany bark, 30 parts of angelica dahurica, 20 parts of belvedere fruit and 25 parts of fried white paeony root.
3. The traditional Chinese medicine composition with the effect of preventing and treating hand-foot syndrome according to claim 1, is characterized by comprising the following components in parts by weight: 10 parts of raw astragalus membranaceus, 15 parts of lithospermum, 8 parts of raw rhubarb, 20 parts of dandelion, 22 parts of cynanchum paniculatum, 15 parts of honey-fried licorice root, 10 parts of angelica sinensis, 12 parts of phellodendron amurense, 13 parts of dittany bark, 28 parts of angelica dahurica, 14 parts of belvedere fruit and 20 parts of fried white paeony root.
4. The traditional Chinese medicine composition with the effect of preventing and treating hand-foot syndrome according to claim 1, is characterized by comprising the following components in parts by weight: 50 parts of raw astragalus root, 40 parts of lithospermum, 25 parts of raw rhubarb, 38 parts of dandelion, 42 parts of paniculate swallowwort root, 35 parts of honey-fried licorice root, 35 parts of angelica, 25 parts of phellodendron, 23 parts of dittany bark, 36 parts of angelica dahurica, 26 parts of belvedere fruit and 33 parts of fried white paeony root.
5. The traditional Chinese medicine composition with the effect of preventing and treating hand-foot syndrome according to claim 1, is characterized by comprising the following components in parts by weight: 11 parts of raw astragalus, 39 parts of lithospermum, 24 parts of raw rhubarb, 37 parts of dandelion, 40 parts of paniculate swallowwort root, 33 parts of honey-fried licorice root, 18 parts of angelica, 24 parts of phellodendron, 22 parts of dittany bark, 29 parts of angelica dahurica, 25 parts of belvedere fruit and 31 parts of fried white paeony root.
6. The traditional Chinese medicine composition with the effect of preventing and treating hand-foot syndrome according to claim 1, is characterized by comprising the following components in parts by weight: 28 parts of raw astragalus, 22 parts of lithospermum, 16 parts of raw rhubarb, 33 parts of dandelion, 26 parts of paniculate swallowwort root, 19 parts of honey-fried licorice root, 27 parts of angelica, 16 parts of phellodendron, 20 parts of dittany bark, 29 parts of angelica dahurica, 17 parts of belvedere fruit and 24 parts of fried white paeony root.
7. The preparation method of the traditional Chinese medicine composition with the effect of preventing and treating hand-foot syndrome according to claim 1, is characterized by comprising the following steps:
weighing 10-50 parts of raw astragalus membranaceus, 15-40 parts of lithospermum, 8-25 parts of raw rhubarb, 20-38 parts of dandelion, 22-42 parts of paniculate swallowwort root, 15-35 parts of honey-fried licorice root, 10-35 parts of angelica, 12-25 parts of phellodendron, 13-23 parts of dittany bark, 28-36 parts of angelica dahurica, 14-26 parts of fructus kochiae and 20-33 parts of fried white paeony root according to parts by weight;
step two, uniformly mixing the raw materials by a stirrer to obtain a mixture;
step three, crushing the mixture by a crusher to obtain mixed powder;
putting the mixed powder into distilled water, heating to 100 ℃, decocting in boiling water for 40-60 min, and then cooling to obtain a cooling liquid;
step five, decocting the cooling liquid again, then decocting for two hours, then cooling to room temperature, and then filtering to obtain a filtrate;
and step six, sterilizing the filtrate, and then packaging to obtain the traditional Chinese medicine preparation.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114522205A (en) * | 2022-03-28 | 2022-05-24 | 江西中医药大学附属医院 | Traditional Chinese medicine composition for treating hand-foot syndrome after targeted drug treatment and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108938759A (en) * | 2017-05-25 | 2018-12-07 | 四川省中医药科学院 | A kind of drug that treating hand-foot syndrome or daily chemical product composition and its preparation method and application |
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Patent Citations (1)
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| CN108938759A (en) * | 2017-05-25 | 2018-12-07 | 四川省中医药科学院 | A kind of drug that treating hand-foot syndrome or daily chemical product composition and its preparation method and application |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114522205A (en) * | 2022-03-28 | 2022-05-24 | 江西中医药大学附属医院 | Traditional Chinese medicine composition for treating hand-foot syndrome after targeted drug treatment and preparation method thereof |
| CN114522205B (en) * | 2022-03-28 | 2023-01-03 | 江西中医药大学附属医院 | Traditional Chinese medicine composition for treating hand-foot syndrome after targeted drug treatment and preparation method thereof |
| GB2617215A (en) * | 2022-03-28 | 2023-10-04 | The Affiliated Hospital Of Jiangxi Univ Of Tcm | Traditional Chinese medicine composition for treating hand-foot syndrome (HFS) after targeted drug treatment and method for making the same |
| GB2617215B (en) * | 2022-03-28 | 2024-03-20 | The Affiliated Hospital Of Jiangxi Univ Of Tcm | Traditional Chinese medicine composition for treating hand-foot syndrome (HFS) after targeted drug treatment and method for making the same |
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