CN112156144A - Traditional Chinese medicine composition, medicine for treating qi deficiency and blood stasis type coronary heart disease with anxiety and depression, and preparation method and application thereof - Google Patents

Traditional Chinese medicine composition, medicine for treating qi deficiency and blood stasis type coronary heart disease with anxiety and depression, and preparation method and application thereof Download PDF

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CN112156144A
CN112156144A CN202011213381.3A CN202011213381A CN112156144A CN 112156144 A CN112156144 A CN 112156144A CN 202011213381 A CN202011213381 A CN 202011213381A CN 112156144 A CN112156144 A CN 112156144A
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radix
traditional chinese
chinese medicine
medicine composition
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高蕊
孙明月
赖书进
李庆娜
赵阳
李英山
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Xiyuan Hospital China Academy Of Chinese Medical Sciences
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Xiyuan Hospital China Academy Of Chinese Medical Sciences
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Abstract

The invention provides a traditional Chinese medicine composition, a medicine for treating qi deficiency and blood stasis type coronary heart disease combined anxiety depression, a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines. The Chinese medicinal composition mainly comprises astragalus, codonopsis pilosula, salvia miltiorrhiza, ligusticum wallichii, red paeony root, safflower, angelica, radix bupleuri, poria cocos, radix paeoniae alba, honey-fried licorice root, pericarpium citri reticulatae, cassia twig, rhizoma pinellinae praeparata and fried bighead atractylodes rhizome. The above Chinese medicinal composition contains radix astragali, radix Codonopsis, Poria, and parched Atractylodis rhizoma, and has effects of invigorating qi and invigorating spleen; the red sage root, the ligusticum wallichii, the red paeony root and the safflower have the effects of activating blood and dissolving stasis; bupleuri radix, pericarpium Citri Tangerinae, rhizoma Ligustici Chuanxiong and rhizoma Pinelliae have effects of dispersing stagnated liver qi and resolving hard mass; meanwhile, the composition also comprises angelica for nourishing blood and activating blood, cassia twig for warming channels and dredging collaterals, white paeony root for nourishing blood and astringing yin, and prepared licorice root for soothing liver without damaging yin blood when being combined with bupleurum. Furthermore, the medicine has the effects of tonifying qi, activating blood circulation, soothing liver and relieving depression, and has a good treatment effect on coronary heart disease combined with anxiety and depression through experimental verification.

Description

Traditional Chinese medicine composition, medicine for treating qi deficiency and blood stasis type coronary heart disease with anxiety and depression, and preparation method and application thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition, a medicine for treating qi deficiency and blood stasis type coronary heart disease complicated with anxiety and depression, and a preparation method and application thereof.
Background
In recent years, with the economic development and the improvement of living standard, the prevalence rate and the death rate of coronary atherosclerotic heart disease (CHD) in China are obviously improved compared with the prior art, and simultaneously, the problem of coronary heart disease complicated with mental disorder is increasingly highlighted. Anxiety and depression are the two most common psychological disorders at present and often occur together, and a large number of studies find that patients with coronary heart disease are often accompanied by anxiety and depressive disorders of different degrees and can affect the progression and prognosis thereof. Meta analysis of epidemiological investigations shows that the time point prevalence of depressive disorders in coronary heart disease populations is 14% -47%, much higher than 4% -7% of the general population, and higher in unstable angina, acute myocardial infarction patients. It is also found that anxiety is positively correlated with fatal cardiovascular events, and multiple prospective research results also show that the risk of cardiac death is remarkably increased for patients with coronary heart disease with anxiety.
In 2006, the Hudao professor in the cardiovascular disease specialty of the Chinese medical society of rehabilitation proposed a 'bixin medicine' model aiming at early recognition, early diagnosis and comprehensive treatment of cardiovascular disease-associated mental disorders from the viewpoint of disease integrity. At present, patients with coronary heart disease complicated with anxiety and depression are mainly treated by adding anti-depression anxiety such as a 5-hydroxytryptamine reuptake inhibitor, a hypnotic sedative and the like, but the medicines have certain toxic and side effects and some medicines conflict with secondary coronary heart disease prevention medicines. The traditional Chinese medicine has unique status and advantages in the aspects of preventing and treating coronary heart disease with anxiety and depression, and has little side effect and high acceptance of patients. The traditional Chinese medicine has a profound understanding on the 'double heart diseases', and thinks that the heart governs blood vessels, also governs mind and prefers mind, so the pathological manifestations of the heart are mainly the obstruction of blood vessel operation and the abnormality of emotional thinking activity. Although traditional Chinese medicines have certain advantages for treating the bixin diseases, a Chinese patent medicine with better curative effect for the bixin diseases is still lacking in clinic at present.
In view of the above, the present invention is particularly proposed.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition and a medicine containing the traditional Chinese medicine composition for treating coronary heart disease combined anxiety and depression.
In order to achieve the above purpose of the present invention, the following technical solutions are adopted:
the invention provides a traditional Chinese medicine composition, which comprises the following components:
radix astragali, radix Codonopsis, parched Atractylodis rhizoma, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, bupleuri radix, Poria, radix Paeoniae alba, Saviae Miltiorrhizae radix, radix Glycyrrhizae Preparata, radix Paeoniae Rubra, pericarpium Citri Tangerinae, Carthami flos, ramulus Cinnamomi and rhizoma Pinelliae Preparata.
Further, the traditional Chinese medicine composition comprises the following components in parts by weight:
20-30 parts of codonopsis pilosula, 20-30 parts of astragalus membranaceus, 10-12 parts of fried bighead atractylodes rhizome, 20-30 parts of poria cocos, 9-15 parts of radix bupleuri, 15-20 parts of radix paeoniae alba, 9-15 parts of salvia miltiorrhiza, 10-20 parts of ligusticum wallichii, 10-15 parts of angelica sinensis, 15-30 parts of radix paeoniae rubra, 10-15 parts of pericarpium citri reticulatae, 10-12 parts of safflower carthamus, 10-15 parts of cassia twig, 10-15 parts of rhizoma pinellinae praeparata and 10-15 parts of radix.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight:
20 parts of codonopsis pilosula, 20 parts of astragalus membranaceus, 10 parts of fried bighead atractylodes rhizome, 20 parts of poria cocos, 10 parts of radix bupleuri, 15 parts of radix paeoniae alba, 15 parts of salvia miltiorrhiza, 15 parts of ligusticum wallichii, 12 parts of angelica sinensis, 20 parts of radix paeoniae rubra, 12 parts of pericarpium citri reticulatae, 10 parts of safflower carthamus, 10 parts of cassia twig, 10 parts of rhizoma pinellinae praeparata and 10 parts of radix glycyrrh.
The invention provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:
mixing the above materials, and making into Chinese medicinal composition.
The invention provides application of the traditional Chinese medicine composition in preparing a medicine for treating coronary heart disease with anxiety and depression.
The invention provides a medicine for treating coronary heart disease with anxiety and depression, which comprises the traditional Chinese medicine composition.
Further, the medicine also comprises a pharmaceutically acceptable carrier and/or excipient.
Furthermore, the dosage form of the medicine comprises any one of powder, pills, tablets, granules, capsules, paste, gels or decoction, and the decoction is preferred.
The preparation method of the decoction medicine provided by the invention comprises the following steps:
the traditional Chinese medicine composition with the formula amount is added into a solvent for decoction to obtain a decoction medicine.
Further, the preparation method also comprises the steps of adding pharmaceutically acceptable carriers and/or excipients into the decoction medicine, and optionally concentrating, optionally drying and optionally granulating to prepare the medicine;
preferably, the dosage form of the medicament comprises any one of powder, pills, tablets, granules, capsules, paste or gels.
Compared with the prior art, the invention has the beneficial effects that:
the traditional Chinese medicine composition provided by the invention mainly comprises the components of astragalus, codonopsis pilosula, salvia miltiorrhiza, ligusticum wallichii, red paeony root, safflower, angelica, radix bupleuri, poria cocos, radix paeoniae alba, honey-fried licorice root, dried orange peel, cassia twig, rhizoma pinellinae praeparata and fried bighead atractylodes rhizome. The above Chinese medicinal composition contains radix astragali, radix Codonopsis, Poria, and parched Atractylodis rhizoma, and has effects of invigorating qi and invigorating spleen; the red sage root, the ligusticum wallichii, the red paeony root and the safflower have the effects of activating blood and dissolving stasis; bupleuri radix, pericarpium Citri Tangerinae, rhizoma Ligustici Chuanxiong and rhizoma Pinelliae have effects of dispersing stagnated liver qi and resolving hard mass; meanwhile, the composition also comprises angelica with the functions of nourishing blood and promoting blood circulation and cassia twig with the functions of warming channels and promoting blood circulation; in addition, white peony root, radix Paeoniae alba nourishes blood and astringes yin, soothes liver and relieves urgency, and is combined with chai Hu to sooth liver without damaging yin blood, and prepared licorice root, radix Glycyrrhizae Praeparata invigorates spleen and tonifies qi to harmonize the other drugs. Therefore, the traditional Chinese medicine composition has the effects of tonifying qi, activating blood, soothing liver and relieving depression through the synergistic compatibility of the medicines, and has a good treatment effect on coronary heart disease combined with anxiety and depression through experimental verification.
The preparation method of the traditional Chinese medicine composition provided by the invention is to uniformly mix all the raw materials to obtain the traditional Chinese medicine composition. The preparation method has the advantages of simple preparation process and easy operation.
The traditional Chinese medicine composition provided by the invention can be widely applied to the preparation process of a medicine for treating coronary heart disease combined with anxiety and depression.
The medicine for treating coronary heart disease combined with anxiety and depression provided by the invention comprises the traditional Chinese medicine composition, and experiments prove that the traditional Chinese medicine composition has a good treatment effect on coronary heart disease combined with anxiety and depression due to the effects of soothing liver, strengthening spleen, tonifying qi and activating blood. Therefore, the medicine containing the compound has good effect of treating coronary heart disease combined with anxiety and depression.
The preparation method of the medicine provided by the invention is to add the traditional Chinese medicine composition with the formula amount into a solvent for decoction to obtain a decoction medicine. The preparation method has the advantages of simple preparation method and high extraction efficiency of effective components.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
According to one aspect of the invention, a traditional Chinese medicine composition comprises the following components:
rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, bupleuri radix, Poria, radix Paeoniae alba, radix Codonopsis, radix astragali, Saviae Miltiorrhizae radix, radix Glycyrrhizae Preparata, radix Paeoniae Rubra, pericarpium Citri Tangerinae, Carthami flos, ramulus Cinnamomi, rhizoma Pinelliae Preparata and parched Atractylodis rhizoma.
The traditional Chinese medicine composition provided by the invention mainly comprises the components of astragalus, codonopsis pilosula, salvia miltiorrhiza, ligusticum wallichii, red paeony root, safflower, angelica, radix bupleuri, poria cocos, radix paeoniae alba, honey-fried licorice root, dried orange peel, cassia twig, rhizoma pinellinae praeparata and fried bighead atractylodes rhizome. The above Chinese medicinal composition contains radix astragali, radix Codonopsis, Poria, and parched Atractylodis rhizoma, and has effects of invigorating qi and invigorating spleen; the red sage root, the ligusticum wallichii, the red paeony root and the safflower have the effects of activating blood and dissolving stasis; bupleuri radix, pericarpium Citri Tangerinae, rhizoma Ligustici Chuanxiong and rhizoma Pinelliae have effects of dispersing stagnated liver qi and resolving hard mass; meanwhile, the composition also comprises angelica with the functions of nourishing blood and promoting blood circulation and cassia twig with the functions of warming channels and promoting blood circulation; in addition, white peony root, radix Paeoniae alba nourishes blood and astringes yin, soothes liver and relieves urgency, and is combined with chai Hu to sooth liver without damaging yin blood, and prepared licorice root, radix Glycyrrhizae Praeparata invigorates spleen and tonifies qi to harmonize the other drugs. Therefore, the traditional Chinese medicine composition has the effects of soothing liver-qi stagnation, tonifying qi and activating blood circulation through the synergistic compatibility of the medicines, and has a good treatment effect on coronary heart disease combined with anxiety and depression through experimental verification.
The term "comprising" as used herein means that the Chinese medicinal composition may further comprise other raw materials acceptable in the field of Chinese medicines in addition to the raw materials, and the other raw materials impart different properties to the Chinese medicinal composition. In addition, the term "comprising" as used herein may be replaced by "being" or "made from … …" as closed.
In a preferred embodiment of the invention, the traditional Chinese medicine composition comprises the following components in parts by weight:
20-30 parts of codonopsis pilosula, 20-30 parts of astragalus membranaceus, 10-12 parts of fried bighead atractylodes rhizome, 20-30 parts of poria cocos, 9-15 parts of radix bupleuri, 15-20 parts of radix paeoniae alba, 9-15 parts of salvia miltiorrhiza, 10-20 parts of ligusticum wallichii, 10-15 parts of angelica sinensis, 15-30 parts of radix paeoniae rubra, 10-15 parts of pericarpium citri reticulatae, 10-12 parts of safflower carthamus, 10-15 parts of cassia twig, 10-15 parts of rhizoma pinellinae praeparata and 10-15 parts of radix;
typical but not limiting parts by weight of the above-mentioned gastrodia elata are, for example, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 18 parts or 20 parts; typical but not limiting parts by weight of the above angelica are, for example, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts or 15 parts; typical but not limiting parts by weight of the above bupleurum are, for example, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts or 15 parts; typical but not limiting parts by weight of the above-mentioned poria cocos are, for example, 20 parts, 22 parts, 24 parts, 25 parts, 26 parts, 28 parts or 30 parts; typical but non-limiting parts by weight of the white peony root are, for example, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts or 20 parts; typical but not limiting parts by weight of the codonopsis pilosula are, for example, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 28 parts, 29 parts or 30 parts; typical but not limiting parts by weight of the astragalus membranaceus are, for example, 16 parts, 18 parts, 20 parts, 22 parts, 24 parts, 25 parts, 26 parts, 28 parts or 30 parts; typical but not limiting parts by weight of the salvia miltiorrhiza are, for example, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts or 15 parts; typical but non-limiting parts by weight of the radix glycyrrhizae preparata bupleurum are, for example, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts or 15 parts; typical but not limiting parts by weight of the above red peony root are, for example, 15 parts, 16 parts, 18 parts, 20 parts, 22 parts, 24 parts, 25 parts, 26 parts, 28 parts or 30 parts; typical but not limiting parts by weight of the dried orange peel are, for example, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts or 15 parts; typical but not limiting parts by weight of the above safflower are for example 10 parts, 11 parts or 12 parts; typical but not limiting parts by weight of the above-mentioned cassia twig are, for example, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts or 15 parts; typical but not limiting parts by weight of the above rhizoma pinellinae praeparata are, for example, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts or 15 parts; typical but non-limiting parts by weight of the above-mentioned parched white atractylodes rhizome are, for example, 10 parts, 11 parts or 12 parts.
In the preferred embodiment, the traditional Chinese medicine composition comprises the following components in parts by weight:
20 parts of codonopsis pilosula, 20 parts of astragalus membranaceus, 10 parts of fried bighead atractylodes rhizome, 20 parts of poria cocos, 10 parts of radix bupleuri, 15 parts of radix paeoniae alba, 15 parts of salvia miltiorrhiza, 15 parts of ligusticum wallichii, 12 parts of angelica sinensis, 20 parts of radix paeoniae rubra, 12 parts of pericarpium citri reticulatae, 10 parts of safflower carthamus, 10 parts of cassia twig, 10 parts of rhizoma pinellinae praeparata and 10 parts of radix glycyrrh.
In order to ensure that the raw materials have better compatibility, the dosage of the traditional Chinese medicine composition is further optimized.
According to one aspect of the invention, a preparation method of the traditional Chinese medicine composition comprises the following steps:
mixing the above materials, and making into Chinese medicinal composition.
The preparation method of the traditional Chinese medicine composition provided by the invention is to uniformly mix all the raw materials to obtain the traditional Chinese medicine composition. The preparation method has the advantages of simple preparation process and easy operation.
According to one aspect of the invention, the application of the traditional Chinese medicine composition in preparing a medicine for treating coronary heart disease combined with anxiety and depression is provided.
The traditional Chinese medicine composition provided by the invention can be widely applied to the preparation process of a medicine for treating coronary heart disease combined with anxiety and depression.
According to one aspect of the invention, the medicine for treating coronary heart disease with anxiety and depression comprises the traditional Chinese medicine composition.
The medicine for treating coronary heart disease combined with anxiety and depression provided by the invention comprises the traditional Chinese medicine composition, and experiments prove that the traditional Chinese medicine composition has a good treatment effect on coronary heart disease combined with anxiety and depression due to the effects of soothing liver, strengthening spleen, tonifying qi and activating blood. Therefore, the medicine containing the compound has good effect of treating coronary heart disease combined with anxiety and depression.
In a preferred embodiment of the present invention, the medicament further comprises a pharmaceutically acceptable carrier and/or excipient.
As a preferred embodiment, the above-mentioned medicament further comprises a pharmaceutically acceptable carrier and/or excipient, wherein "and/or" means that the raw materials of the Chinese medicinal composition may only comprise the carrier, or the raw materials of the Chinese medicinal composition may only comprise the excipient, or the raw materials of the Chinese medicinal composition may comprise both the carrier and the excipient.
In the present invention, the specific types of the excipient and the carrier are not limited, and the excipient, such as water, wine, vinegar, or medicinal juice, which is commonly used in the field of Chinese medicinal preparations, may be used. The carrier can be common carrier in Chinese medicinal preparation field.
In a preferred embodiment of the present invention, the dosage form of the medicament includes any one of powder, pill, tablet, granule, capsule, paste, gel or decoction, preferably decoction.
As a preferred embodiment, the dosage form of the above medicine can be various forms such as powder, pill, tablet, granule, capsule, paste, gel or decoction; meanwhile, the preparation of various dosage forms can be realized by adopting the common process in the field, and the details are not repeated.
According to one aspect of the invention, the preparation method of the decoction medicine comprises the following steps:
the traditional Chinese medicine composition with the formula amount is added into a solvent for decoction to obtain a decoction medicine.
The preparation method of the medicine provided by the invention is to add the traditional Chinese medicine composition with the formula amount into a solvent for decoction to obtain a decoction medicine. The preparation method has the advantages of simple preparation method and high extraction efficiency of effective components.
In a preferred embodiment of the present invention, the preparation method further comprises the steps of adding pharmaceutically acceptable carriers and/or excipients to the decoction medicine, and optionally concentrating, optionally drying and optionally granulating to prepare the medicine;
preferably, the dosage form of the medicament comprises any one of powder, pills, tablets, granules, capsules, paste or gels.
In the present invention, "optionally dried" means that drying may be performed or may not be performed. By "optionally granulated" is meant that granulation may or may not be performed. Whether the drying and the granulation are carried out depends on the final dosage form of the Chinese medicinal composition. For example, when the Chinese medicinal composition is prepared into granules, drying and granulation are required. When the traditional Chinese medicine composition is prepared into decoction, drying and granulation are not required.
In the above preferred embodiment, the dosage form of the medicament includes any one of powder, pill, tablet, granule, capsule, paste or gel.
As a preferred embodiment, the Chinese medicinal composition of the present application can be prepared into pharmaceutical preparations, such as external preparations, ointments, gels, etc., such as tablets, capsules, granules, pills, medicinal decoctions, etc., by combining with carriers or excipients by a known method in pharmacy.
The technical solution of the present invention will be further described with reference to examples and comparative examples.
Note: the method of concentration, drying and granulation in the preparation of the granular drug of the examples and comparative examples described below in this application is not particularly limited, and can be carried out by a method known to those skilled in the art.
Example 1
A medicine for treating coronary heart disease with anxiety and depression, the preparation method of the medicine comprises:
the traditional Chinese medicine composition for treating coronary heart disease combined with anxiety and depression is added into water for decoction, and the obtained decoction is concentrated, dried and granulated to obtain the granular medicine.
The traditional Chinese medicine composition for treating coronary heart disease combined with anxiety and depression comprises the following raw materials in parts by weight:
10 parts of ligusticum wallichii, 15 parts of angelica, 15 parts of radix bupleuri, 30 parts of poria cocos, 15 parts of radix paeoniae alba, 30 parts of codonopsis pilosula, 20 parts of astragalus membranaceus, 9 parts of salvia miltiorrhiza, 10 parts of honey-fried licorice root, 30 parts of red paeony root, 10 parts of pericarpium citri reticulatae, 12 parts of safflower carthamus, 10 parts of cassia twig, 15 parts of rhizoma pinellinae praeparata and 10 parts of fried bighead atractylodes.
Example 2
The embodiment is the same as the embodiment 1 except that the content and the composition of the traditional Chinese medicine composition for treating coronary heart disease combined with anxiety and depression are different from the embodiment 1;
the traditional Chinese medicine composition for treating coronary heart disease combined with anxiety and depression comprises the following raw materials in parts by weight:
20 parts of ligusticum wallichii, 10 parts of angelica sinensis, 9 parts of radix bupleuri, 20 parts of poria cocos, 20 parts of radix paeoniae alba, 20 parts of codonopsis pilosula, 30 parts of astragalus membranaceus, 15 parts of salvia miltiorrhiza, 15 parts of honey-fried licorice root, 15 parts of red paeony root, 15 parts of pericarpium citri reticulatae, 10 parts of safflower carthamus, 15 parts of cassia twig, 10 parts of rhizoma pinellinae praeparata and 12 parts of fried bighead.
Example 3
The embodiment is the same as the embodiment 1 except that the content and the composition of the traditional Chinese medicine composition for treating coronary heart disease combined with anxiety and depression are different from the embodiment 1;
the traditional Chinese medicine composition for treating coronary heart disease combined with anxiety and depression comprises the following raw materials in parts by weight:
12 parts of ligusticum wallichii, 11 parts of angelica, 12 parts of radix bupleuri, 22 parts of poria cocos, 16 parts of radix paeoniae alba, 21 parts of codonopsis pilosula, 28 parts of astragalus membranaceus, 10 parts of salvia miltiorrhiza, 12 parts of honey-fried licorice root, 15 parts of red paeony root, 12 parts of pericarpium citri reticulatae, 11 parts of safflower carthamus, 12 parts of cassia twig, 12 parts of rhizoma pinellinae praeparata and 11 parts of fried bighead atractylodes.
Example 4
The embodiment is the same as the embodiment 1 except that the content and the composition of the traditional Chinese medicine composition for treating coronary heart disease combined with anxiety and depression are different from the embodiment 1;
the traditional Chinese medicine composition for treating coronary heart disease combined with anxiety and depression comprises the following raw materials in parts by weight:
15 parts of ligusticum wallichii, 12 parts of angelica, 11 parts of radix bupleuri, 25 parts of poria cocos, 18 parts of radix paeoniae alba, 25 parts of codonopsis pilosula, 25 parts of astragalus membranaceus, 13 parts of salvia miltiorrhiza, 12 parts of honey-fried licorice root, 20 parts of red paeony root, 12 parts of pericarpium citri reticulatae, 10 parts of safflower, 12 parts of cassia twig, 12 parts of rhizoma pinellinae praeparata and 10 parts of fried bighead atractylodes rhizome.
Example 5
The comparison example is the same as example 4 except that the traditional Chinese medicine composition for treating coronary heart disease with anxiety and depression comprises 8 parts of ligusticum wallichii, 18 parts of angelica sinensis and 15 parts of radix bupleuri.
Example 6
The comparison example is the same as example 4 except that the traditional Chinese medicine composition for treating coronary heart disease combined with anxiety and depression comprises 22 parts of white paeony root, 17 parts of codonopsis pilosula and 32 parts of astragalus.
Example 7
The embodiment is the same as the embodiment 4 except that the traditional Chinese medicine composition for treating coronary heart disease combined with anxiety and depression also comprises 10 parts of cape jasmine fruit, 12 parts of rhodiola rosea, 12 parts of rhizoma acori graminei and 10 parts of cortex moutan.
Comparative example 1
The comparative example is the same as example 4 except that the traditional Chinese medicine composition for treating coronary heart disease with anxiety and depression does not contain radix bupleuri, poria cocos and radix paeoniae alba.
Experimental example 1
The medicine for treating coronary heart disease combined with anxiety and depression has the advantage of obvious treatment effect on coronary heart disease combined with anxiety and depression. 160 patients with coronary heart disease with mild and moderate qi deficiency and blood stasis, combined with anxiety and depression are specially selected, the age is 15-60 years old, the patients are averagely divided into 8 groups, and each group comprises 20 patients; wherein the test groups 1-7 are treated with the granular medicines prepared in examples 1-7 respectively, 8g each time, three times a day; experimental group 8 was treated with a control using commercially available xiaoyao granules as a control.
The treatment effect of the patients is observed and counted according to the diagnosis scale of qi deficiency and blood stasis in 60 days, and the specific results are shown in the following table 1:
table 1:
Figure BDA0002758949730000111
Figure BDA0002758949730000121
as shown in the table above, the traditional Chinese medicine composition is mainly used for improving symptoms of chest distress, chest pain, hypodynamia, emotional disorder and the like of patients with the double heart diseases, and has more obvious effect of improving the hypodynamia and chest pain compared with the Xiaoyao granules.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims (10)

1. A traditional Chinese medicine composition is characterized by comprising the following components:
radix astragali, radix Codonopsis, parched Atractylodis rhizoma, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, bupleuri radix, Poria, radix Paeoniae alba, Saviae Miltiorrhizae radix, radix Glycyrrhizae Preparata, radix Paeoniae Rubra, pericarpium Citri Tangerinae, Carthami flos, ramulus Cinnamomi and rhizoma Pinelliae Preparata.
2. The traditional Chinese medicine composition according to claim 1, which comprises the following components in parts by weight:
20-30 parts of codonopsis pilosula, 20-30 parts of astragalus membranaceus, 10-12 parts of fried bighead atractylodes rhizome, 20-30 parts of poria cocos, 9-15 parts of radix bupleuri, 15-20 parts of radix paeoniae alba, 9-15 parts of salvia miltiorrhiza, 10-20 parts of ligusticum wallichii, 10-15 parts of angelica sinensis, 15-30 parts of radix paeoniae rubra, 10-15 parts of pericarpium citri reticulatae, 10-12 parts of safflower carthamus, 10-15 parts of cassia twig, 10-15 parts of rhizoma pinellinae praeparata and 10-15 parts of radix.
3. The traditional Chinese medicine composition according to claim 1, which comprises the following components in parts by weight:
20 parts of codonopsis pilosula, 20 parts of astragalus membranaceus, 10 parts of fried bighead atractylodes rhizome, 20 parts of poria cocos, 10 parts of radix bupleuri, 15 parts of radix paeoniae alba, 15 parts of salvia miltiorrhiza, 15 parts of ligusticum wallichii, 12 parts of angelica sinensis, 20 parts of radix paeoniae rubra, 12 parts of pericarpium citri reticulatae, 10 parts of safflower carthamus, 10 parts of cassia twig, 10 parts of rhizoma pinellinae praeparata and 10 parts of radix glycyrrh.
4. A method for preparing the traditional Chinese medicine composition according to any one of claims 1 to 3, which comprises the following steps:
mixing the above materials, and making into Chinese medicinal composition.
5. An application of the traditional Chinese medicine composition according to any one of claims 1-3 in preparing a medicine for treating coronary heart disease with anxiety and depression.
6. A medicine for treating coronary heart disease with anxiety and depression, which is characterized by comprising the traditional Chinese medicine composition of any one of claims 1-3.
7. The medicament of claim 6, further comprising a pharmaceutically acceptable carrier and/or excipient.
8. The medicament of claim 6, wherein the dosage form of the medicament comprises any one of powder, pills, tablets, granules, capsules, paste, gels or decoction, preferably decoction.
9. A method for preparing a medicament according to any one of claims 6 to 8, comprising the steps of:
the traditional Chinese medicine composition with the formula amount is added into a solvent for decoction to obtain the medicine.
10. A process for the preparation of a medicament according to claim 9, characterized in that it further comprises the steps of adding a pharmaceutically acceptable carrier and/or excipient, and optionally concentrating, optionally drying and optionally granulating to prepare a medicament;
preferably, the dosage form of the medicament comprises any one of powder, pills, tablets, granules, capsules, paste or gels.
CN202011213381.3A 2020-11-03 2020-11-03 Traditional Chinese medicine composition, medicine for treating qi deficiency and blood stasis type coronary heart disease with anxiety and depression, and preparation method and application thereof Pending CN112156144A (en)

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Publication number Priority date Publication date Assignee Title
CN114558074A (en) * 2022-03-15 2022-05-31 江苏省中医院 Traditional Chinese medicine composition for treating metabolic-related fatty liver disease and preparation method and application thereof
CN116870121A (en) * 2023-08-18 2023-10-13 北京中医药大学东方医院 Traditional Chinese medicine composition for treating double heart disease and preparation method and application thereof

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* Cited by examiner, † Cited by third party
Title
朱天翔等: "从气血论冠心病伴焦虑症的中医病机及"双心"治疗", 《江苏中医药》 *
杨璇妹等: "运用"双心同治"理论治疗冠心病", 《中国中医急症》 *

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114558074A (en) * 2022-03-15 2022-05-31 江苏省中医院 Traditional Chinese medicine composition for treating metabolic-related fatty liver disease and preparation method and application thereof
CN114558074B (en) * 2022-03-15 2023-08-01 江苏省中医院 Traditional Chinese medicine composition for treating metabolic-related fatty liver disease and preparation method and application thereof
CN116870121A (en) * 2023-08-18 2023-10-13 北京中医药大学东方医院 Traditional Chinese medicine composition for treating double heart disease and preparation method and application thereof
CN116870121B (en) * 2023-08-18 2024-04-02 北京中医药大学东方医院 Traditional Chinese medicine composition for treating double heart disease and preparation method and application thereof

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Application publication date: 20210101