CN113143958A - 扩大使用硅酸锆组合物及其使用方法 - Google Patents

扩大使用硅酸锆组合物及其使用方法 Download PDF

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Publication number
CN113143958A
CN113143958A CN202110531403.9A CN202110531403A CN113143958A CN 113143958 A CN113143958 A CN 113143958A CN 202110531403 A CN202110531403 A CN 202110531403A CN 113143958 A CN113143958 A CN 113143958A
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composition
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ppm
zirconium silicate
ion
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Pending
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CN202110531403.9A
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English (en)
Chinese (zh)
Inventor
D.J.凯泽
A.F.吉勒姆
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ZS Pharma Inc
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ZS Pharma Inc
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Application filed by ZS Pharma Inc filed Critical ZS Pharma Inc
Publication of CN113143958A publication Critical patent/CN113143958A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/02—Processes using inorganic exchangers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/14—Base exchange silicates, e.g. zeolites
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B39/00—Compounds having molecular sieve and base-exchange properties, e.g. crystalline zeolites; Their preparation; After-treatment, e.g. ion-exchange or dealumination
    • C01B39/02—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof; Direct preparation thereof; Preparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactants; After-treatment thereof
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B39/00—Compounds having molecular sieve and base-exchange properties, e.g. crystalline zeolites; Their preparation; After-treatment, e.g. ion-exchange or dealumination
    • C01B39/02—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof; Direct preparation thereof; Preparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactants; After-treatment thereof
    • C01B39/06—Preparation of isomorphous zeolites characterised by measures to replace the aluminium or silicon atoms in the lattice framework by atoms of other elements, i.e. by direct or secondary synthesis
    • C01B39/08—Preparation of isomorphous zeolites characterised by measures to replace the aluminium or silicon atoms in the lattice framework by atoms of other elements, i.e. by direct or secondary synthesis the aluminium atoms being wholly replaced
    • C01B39/085—Group IVB- metallosilicates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2002/00—Crystal-structural characteristics
    • C01P2002/70—Crystal-structural characteristics defined by measured X-ray, neutron or electron diffraction data
    • C01P2002/72—Crystal-structural characteristics defined by measured X-ray, neutron or electron diffraction data by d-values or two theta-values, e.g. as X-ray diagram
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/61—Micrometer sized, i.e. from 1-100 micrometer

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Geology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Materials Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN202110531403.9A 2015-10-14 2016-10-10 扩大使用硅酸锆组合物及其使用方法 Pending CN113143958A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/883,428 US9592253B1 (en) 2015-10-14 2015-10-14 Extended use zirconium silicate compositions and methods of use thereof
US14/883428 2015-10-14
CN201680059460.9A CN108137620B (zh) 2015-10-14 2016-10-10 扩大使用硅酸锆组合物及其使用方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201680059460.9A Division CN108137620B (zh) 2015-10-14 2016-10-10 扩大使用硅酸锆组合物及其使用方法

Publications (1)

Publication Number Publication Date
CN113143958A true CN113143958A (zh) 2021-07-23

Family

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Family Applications (2)

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CN202110531403.9A Pending CN113143958A (zh) 2015-10-14 2016-10-10 扩大使用硅酸锆组合物及其使用方法
CN201680059460.9A Active CN108137620B (zh) 2015-10-14 2016-10-10 扩大使用硅酸锆组合物及其使用方法

Family Applications After (1)

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CN201680059460.9A Active CN108137620B (zh) 2015-10-14 2016-10-10 扩大使用硅酸锆组合物及其使用方法

Country Status (19)

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US (4) US9592253B1 (OSRAM)
EP (1) EP3362456A4 (OSRAM)
JP (1) JP6546700B2 (OSRAM)
KR (1) KR102667566B1 (OSRAM)
CN (2) CN113143958A (OSRAM)
AR (1) AR106369A1 (OSRAM)
AU (1) AU2016338753C1 (OSRAM)
CA (1) CA3000950C (OSRAM)
CL (1) CL2018000916A1 (OSRAM)
CR (1) CR20180276A (OSRAM)
EA (2) EA202091273A1 (OSRAM)
HK (1) HK1254808A1 (OSRAM)
IL (1) IL258478B (OSRAM)
MX (1) MX2018004440A (OSRAM)
MY (1) MY187088A (OSRAM)
PH (1) PH12018500786B1 (OSRAM)
TW (1) TWI742004B (OSRAM)
WO (1) WO2017066128A1 (OSRAM)
ZA (1) ZA201803095B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117735564A (zh) * 2023-12-19 2024-03-22 杭州国瑞生物科技有限公司 一种环硅酸锆钠的b晶型及其制备方法与应用

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI2673237T4 (fi) 2011-02-11 2025-12-12 Zs Pharma Inc Zirkoniumsilikaatin käyttö hyperkalemian hoitamiseen
US9592253B1 (en) * 2015-10-14 2017-03-14 ZS Pharma, Inc. Extended use zirconium silicate compositions and methods of use thereof
WO2019092179A1 (en) * 2017-11-10 2019-05-16 Sandoz Ag Pharmaceutical compositions comprising zs-9
JP2022524454A (ja) 2019-03-13 2022-05-02 アストラゼネカ・アクチエボラーグ 血液透析患者に使用するカリウム結合剤
CN117342570B (zh) * 2023-09-04 2026-02-10 杭州国瑞生物科技有限公司 一种环硅酸锆钠的a晶型及其制备方法
CN120172420B (zh) * 2025-03-21 2025-12-23 时森海(杭州)医药科技有限公司 控制粒径分布的环硅酸锆钠及其制备方法
CN120984211A (zh) * 2025-06-13 2025-11-21 时森海(杭州)医药科技有限公司 生产环硅酸锆钠的反应器和方法

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WO2015070019A1 (en) * 2013-11-08 2015-05-14 ZS Pharma, Inc. Microporous zirconium silicate for the treatment of hyperkalemia
CN104797263A (zh) * 2012-10-22 2015-07-22 Zs制药公司 用于治疗高钾血症的微孔硅酸锆

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117735564A (zh) * 2023-12-19 2024-03-22 杭州国瑞生物科技有限公司 一种环硅酸锆钠的b晶型及其制备方法与应用
CN117735564B (zh) * 2023-12-19 2025-12-19 杭州国瑞生物科技有限公司 一种环硅酸锆钠的b晶型及其制备方法与应用

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KR102667566B1 (ko) 2024-05-22
EA202091273A1 (ru) 2021-02-03
EP3362456A4 (en) 2019-05-15
CN108137620B (zh) 2021-05-18
CA3000950C (en) 2023-10-31
EA035890B1 (ru) 2020-08-27
AR106369A1 (es) 2018-01-10
EA201890875A1 (ru) 2018-11-30
EP3362456A1 (en) 2018-08-22
AU2016338753A1 (en) 2018-04-12
KR20180067614A (ko) 2018-06-20
ZA201803095B (en) 2019-11-27
AU2016338753C1 (en) 2019-08-08
PH12018500786B1 (en) 2022-09-07
WO2017066128A1 (en) 2017-04-20
US9592253B1 (en) 2017-03-14
HK1254808A1 (zh) 2019-07-26
CA3000950A1 (en) 2017-04-20
US20240009229A1 (en) 2024-01-11
US10300087B2 (en) 2019-05-28
CL2018000916A1 (es) 2018-08-17
MX2018004440A (es) 2018-07-06
TW201717972A (zh) 2017-06-01
PH12018500786A1 (en) 2018-10-29
TWI742004B (zh) 2021-10-11
IL258478B (en) 2020-09-30
US12582673B2 (en) 2026-03-24
JP2018530596A (ja) 2018-10-18
AU2016338753B2 (en) 2019-04-18
US11738044B2 (en) 2023-08-29
US20170151279A1 (en) 2017-06-01
BR112018007189A2 (en) 2018-10-16
MY187088A (en) 2021-08-30
JP6546700B2 (ja) 2019-07-17
CN108137620A (zh) 2018-06-08
NZ740931A (en) 2024-12-20
US20190365800A1 (en) 2019-12-05
CR20180276A (es) 2018-09-19
IL258478A (en) 2018-05-31

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